CN214950168U

CN214950168U - Cross contamination prevention type freeze dryer

Info

Publication number: CN214950168U
Application number: CN202121054430.3U
Authority: CN
Inventors: 田萍; 崔荣龙; 苟文文; 谢娟; 李朝圣; 刘海洋; 王恒路
Original assignee: Sichuan Zhonghuan Lianshu Environmental Consulting Service Co ltd
Current assignee: Sichuan Zhonghuan Lianshu Environmental Consulting Service Co ltd
Priority date: 2021-05-17
Filing date: 2021-05-17
Publication date: 2021-11-30
Anticipated expiration: 2031-05-17

Abstract

The utility model discloses a prevent cross contamination formula freeze dryer, including freezer and the sample room of connecting from top to bottom, inside freezing chamber and the heat exchange system of being provided with of freezer, heat exchange system includes the compressor, condenser, expansion valve and the evaporimeter that the parcel is in freezing the outside cold trap in chamber and connect gradually, provides the cold source for freezing the chamber. The sample chamber comprises an organic glass cover and a sample frame, and a downward-inclined silica gel plate is arranged at the bottom of the organic glass cover; the bottom two sides of the sample frame are provided with annular clamping columns, the bottom of the sample frame is clamped with a baffle A, a baffle B located at the upper end of the freezing chamber is sequentially arranged below the baffle A, the upper surface of the baffle B is provided with a clamping groove matched with the annular clamping columns, and the lower end of the silica gel plate is attached to the outer side of the clamping groove. Can carry out precooling, freezing and drying to the sample through this device, need not change and remove the sample to can avoid leading to the sample to waft because of the air velocity is too fast when carrying out the pressure release, arouse cross contamination.

Description

Cross contamination prevention type freeze dryer

Technical Field

The utility model belongs to the technical field of laboratory glassware, concretely relates to prevent cross contamination formula freeze dryer.

Background

Freeze drying is a technology for drying by utilizing the sublimation principle, namely, a substance to be dried is quickly frozen at a low temperature, then frozen water molecules are directly sublimated into water vapor to escape in a vacuum environment, and other substances to be detected still remain in a sample. The freeze dryer is widely applied to detection of third-party detection institutions, research of scientific units, higher schools and the like. After the sample is dried, the conventional freeze dryer generally adopts the manual pressure relief at the position of the sample chamber externally connected with the sample bottle for pressure relief operation. Because the manual pressure relief operation is not easy to control, the pressure relief is easy to cause over-quick, so that samples of the organic glass cover are blown away, cross contamination among the samples is caused, and the detection accuracy of the samples is influenced; meanwhile, the blown sample is partially deposited on the sealing ring and is not easy to clean. When the sample freeze-drying device is used for the second time, if the sample of the sealing ring is not cleaned up, the sealing is not tight, the freeze-drying sample cannot be carried out, and meanwhile, the abrasion of the sealing ring can be accelerated.

SUMMERY OF THE UTILITY MODEL

The utility model aims at providing an prevent cross contamination formula freeze dryer can carry out precooling, freezing and drying to the sample, need not change and remove the sample to can avoid leading to the sample to waft because of the air velocity is too fast when aerifing and exhausting, arouse cross infection.

In order to achieve the above purpose, the technical scheme adopted by the utility model is as follows: the freezing dryer comprises a freezing chamber and a sample chamber which are connected up and down, wherein a freezing cavity and a heat exchange system are arranged in the freezing chamber, the heat exchange system comprises a cold trap wrapped outside the freezing cavity, the freezing cavity is connected with a vacuum pump through an external pipeline with an electromagnetic valve, and the electromagnetic valve is electrically connected with a controller; the sample chamber comprises an organic glass cover and a sample frame positioned in the organic glass cover, and a downward-inclined silica gel plate is arranged on the inner side of the bottom of the organic glass cover; the bottom two sides of the sample frame are provided with annular clamping columns, the bottom of the sample frame is clamped with a baffle A, a baffle B located at the upper end of the freezing chamber is arranged below the baffle A, the upper surface of the baffle B is provided with a clamping groove matched with the annular clamping columns, and the lower end of the silica gel plate is attached to the outer side of the clamping groove.

The beneficial effect who adopts above-mentioned scheme is: the freezing chamber can finish the steps of precooling, heat preservation and freezing of the sample, the sample chamber is used for vacuumizing environment and placing the sample, the freezing chamber and the sample chamber are separated, and the sample is prevented from entering the freezing chamber, polluting instruments such as a pump machine and the like and causing damage and difficulty in cleaning the instruments. The outside parcel of freezing chamber has the cold trap wherein, can carry out the heat exchange with heat exchange system through the cold trap to reach cryogenic purpose, draw the vacuum environment by vacuum pump work, extract freezing chamber to the moisture in the sample after the precooling in the sample room. The external gas enters the sample chamber through the electromagnetic valve, and the gas enters the sample chamber after being buffered by the freezing chamber by controlling the opening of the electromagnetic valve, and is matched with the baffle plate A and the baffle plate B to reduce the possibility of the sample on the sample frame floating; wherein the controller can be an ohm dragon CP1H-X40DT-D PLC controller.

Further, the heat exchange system further comprises a compressor, a condenser, an expansion valve and an evaporator which are connected through pipelines, the cold trap is respectively connected with the compressor and the evaporator, and the heat exchange system is electrically connected with the controller and the control panel.

The beneficial effect who adopts above-mentioned scheme is: the compressor sucks the low-pressure refrigerant in the evaporator into a compressor cylinder, and the refrigerant vapor is compressed, so that the pressure and the temperature are simultaneously increased; the high-pressure high-temperature refrigerant vapor is pressed to the condenser, the refrigerant vapor with higher temperature exchanges heat with cooling water or air with lower temperature in the condenser, the heat of the refrigerant is taken away by the water or the air to be condensed, and the refrigerant vapor is changed into liquid. The part of liquid is sent to an expansion valve, is throttled into low-temperature and low-pressure liquid by the expansion valve and enters an evaporator; the low-temperature and low-pressure refrigerant liquid in the evaporator absorbs the heat of the compressed air to be vaporized (commonly called as 'evaporation'), and the compressed air is condensed into a large amount of liquid water after being cooled; refrigerant vapor in the evaporator is sucked away by the compressor, so that the refrigerant is subjected to four processes of compression, condensation, throttling and evaporation in the system to exchange heat with water molecules and air in the cold trap after being vacuumized, and a cycle is completed.

Further, baffle B's shape is the hollow cylinder of no bottom surface, and baffle B's lower surface passes through the round hole and is connected with freezing chamber, and the upper surface in freezing chamber is provided with the sealing washer, sealing washer inner ring and baffle B's side swing joint, the inboard swing joint of sealing washer outer ring and organic glass cover, the lower extreme laminating of silica gel board is close to the direction of draw-in groove at the sealing washer inner ring to keep the interval more than 5mm with the sealing washer inner ring.

The beneficial effect who adopts above-mentioned scheme is: the round hole of baffle B connects the sample room and freezes the chamber as gaseous passageway, and the sealing washer can cover organic glass and baffle B is sealed, makes gaseous only can cover the inside circulation at organic glass, and the lower extreme laminating of silica gel board is in the centre of sealing washer inner ring and draw-in groove, can make the sample collection of omitting on the silica gel board on baffle B, and can not pollute the sealing washer, leads to clean dynamics to strengthen.

Furthermore, a boss structure is arranged at the lower part of the sealing ring, a positioning hole is arranged above the freezing chamber, and the boss structure is movably connected with the positioning hole.

The beneficial effect who adopts above-mentioned scheme is: the sealing ring can seal the joint of the sample chamber and the freezing chamber, and the damage of the instrument caused by unstable air pressure is avoided.

Furthermore, the sample rack comprises pillars on two sides, pull rods welded above the pillars, and a plurality of layers of storage racks welded between the storage racks, wherein a plurality of discs are arranged on the storage racks, and the outer distance between the pillars is smaller than the diameter of the baffle B.

The beneficial effect who adopts above-mentioned scheme is: the sample frame provides the support through the pillar of both sides, and the disc can be placed to the supporter in the middle, and on the disc was placed in to the sample, the operation of carrying out drawing through the pull rod of top can be with sample frame to baffle B on or take off from baffle B.

Further, a plurality of holes are uniformly formed in the baffle A, and the diameter of each hole is smaller than 5 mm.

The beneficial effect who adopts above-mentioned scheme is: during the pressure release, external gas passes through solenoid valve and gets into the sample room, sets for solenoid valve's aperture through control, and gaseous back through freezing chamber buffering is at the even sample room that gets into of aperture on the baffle AB, can avoid rocking the unrestrained because of too big sample dish or sample that leads to of impact force, has reduced cross infection's risk.

Furthermore, the external pipeline is provided with a pressure sensor at one end inside the freezing cavity, and the pressure sensor is electrically connected with the controller.

The beneficial effect who adopts above-mentioned scheme is: the pressure sensor is used for detecting the internal pressure of the sample chamber, and when the air is inflated to a certain degree, the internal pressure of the sample chamber is consistent with the atmospheric pressure, the controller can close the electromagnetic valve, and the air is stopped from being inflated. The model of the pressure sensor can be MPM 285.

Furthermore, a plurality of exhaust ports are uniformly formed in the upper end of the outer portion of the sample chamber and connected with a U-shaped pipeline, and a sample bottle connecting port and a valve are arranged on the U-shaped pipeline.

The beneficial effect who adopts above-mentioned scheme is: can discharge inside gas through the gas vent, slowly open the glass cover again, take out the sample of drying on the sample frame to it can be affiliated to the connection with the sample bottle to be provided with the sample bottle connector on the U type pipeline, increases the freezing quantity of sample, improves work efficiency.

To sum up, the utility model has the advantages of it is following:

1. the utility model is a one-machine device, can carry out precooling, freezing and drying operations on the sample, has multiple functions, saves cost, occupies small area and is convenient for the operation of experimenters;

2. the automatic pressure relief valve is arranged in the cold trap, so that the air flow can be effectively controlled in the pressure relief process, and the phenomenon that the sample is lost and cross contamination is caused due to overlarge air flow during manual pressure relief is prevented;

3. the utility model arranges the baffle plate in the sample cavity, which can effectively avoid the sample scattering on the sealing ring, reduce the difficulty of cleaning the sealing ring, and avoid the system air leakage and influence on the service life of the sealing ring caused by the unclean cleaning of the sample;

4. the utility model discloses an increase external sample bottle, promote freeze dryer's capacity, improve work efficiency.

Drawings

FIG. 1 is a schematic view of the present invention;

wherein, 1, freezing chamber; 2. a sample chamber; 3. an evaporator; 4. a compressor; 5. an expansion valve; 6. a condenser; 7. cold trap; 8. a vacuum pump; 9. an electromagnetic valve; 10. a circular hole; 11. a seal ring; 12. a silica gel plate; 13. an annular clamp column; 14. a card slot; 15. a sample holder; 16. a baffle A; 17. an organic glass cover; 18. a sample bottle connection port; 19. a valve; 20. a U-shaped pipeline; 21. a freezing chamber; 151 rack; 152. a pull rod.

Detailed Description

The following detailed description of the embodiments of the present invention will be made with reference to the accompanying drawings.

In one embodiment of the present invention, as shown in fig. 1, there is provided a freeze dryer which provides an anti-cross contamination, a freezing chamber 1 and a sample chamber 2 which are movably connected through a baffle B, a freezing chamber 21 is arranged at the upper part of the freezing chamber 1, a cold trap 7 is wrapped outside the freezing chamber 21, the freezing chamber 21 is connected with a vacuum pump 8 through an external pipeline with an electromagnetic valve 9, wherein the heat exchange system also comprises a compressor 4, a condenser 6, an expansion valve 5 and an evaporator 3 which are connected by pipelines, the evaporator 3 is a device for conveying cold, the refrigerant absorbs the heat of the compressed air in the evaporator to realize the purpose of dehydration and drying, the compressor 4 is a heart and plays the roles of sucking, compressing and conveying the refrigerant steam, and the condenser 6 is a device for releasing heat and transmits the heat absorbed in the evaporator 3 and the heat converted by the input power of the compressor 4 to the cooling medium to be taken away. The expansion valve 5, i.e., a throttle valve, performs a throttling and depressurizing function on the refrigerant while controlling and regulating the amount of refrigerant liquid flowing into the evaporator 3 and dividing the heat exchange system into two sections of a high pressure side and a low pressure side. The refrigerant circulates through the system, changes state, and exchanges heat with the compressed air and the cooling medium.

The sample chamber 2 comprises an organic glass cover 17 and a sample frame 15 positioned in the organic glass cover 17, and a downward-inclined silica gel plate 12 is arranged on the inner side of the bottom of the organic glass cover 17; the two sides of the bottom of the sample holder 15 are provided with annular clamping columns 13, the bottom of the sample holder 15 is clamped with a baffle A16, a baffle B located on the upper surface of the freezing cavity 21 is arranged below the baffle A16, the upper surface of the baffle B is provided with a clamping groove 14 matched with the annular clamping columns 13, and the lower end of the silica gel plate 12 is attached to the outer side of the clamping groove 14. Baffle B's shape is the hollow cylinder of no bottom surface, and baffle B's lower surface passes through round hole 10 and is connected with freezing chamber 21, and the upper surface of freezing chamber 21 is provided with sealing

washer

11, and 11 inner rings of sealing washer and baffle B's side swing joint, the inboard swing joint of 11 outer rings of sealing washer and organic glass cover 17, the lower extreme laminating of silica gel board 12 is close to the direction of draw-in groove 14 at 11 inner rings of sealing washer to keep the interval more than 5mm with 11 inner rings of sealing washer.

The sample holder 15 includes pillars on two sides, a pull rod 152 welded above the pillars, and a plurality of layers of holders 151 welded between the pillars, wherein the holders 151 are provided with a plurality of discs, and the outer space between the pillars is smaller than the diameter of the baffle B. A plurality of holes are uniformly arranged on the baffle A16, and the diameter of each hole is less than 5 mm. And then the gas is shunted through the holes on the baffle A16, the samples on the disc are impacted at different angles, and shaking caused by uneven stress is avoided.

Wherein, the one end that external pipeline stretches into freezing chamber 21 is provided with pressure sensor, and pressure sensor and controller electric connection. The lower part of the sealing ring 11 is provided with a boss structure which is movably connected with a positioning hole above the freezing chamber 1. A plurality of exhaust ports are uniformly arranged at the upper end of the outer part of the sample chamber 2 and are connected with a U-shaped pipeline 20, and a valve 19 and a sample bottle connecting port 18 are arranged on the U-shaped pipeline 20. The sealing ring 11 can seal the connection part of the sample chamber 2 and the freezing chamber 21, and avoid the damage of the instrument caused by unstable air pressure.

The using method comprises the following steps: firstly, putting a sample on a disc, then placing the disc on a storage rack 151, closing all valves of the anti-cross-contamination type freeze dryer, fixing a sealing ring 11 through a boss structure and a positioning hole structure of the sealing ring 11, finally clamping a sample rack 15 with a freezing chamber 1 by using an annular clamping column 13 and a clamping groove 14, then covering the whole instrument with an organic glass cover 17, and pressing the organic glass cover 17 to seal and close the organic glass cover 17 and the sealing ring 11. Opening the control panel to start the heat exchange system, sucking the low-pressure refrigerant in the evaporator 3 into a cylinder of the compressor 4 by the compressor 4, compressing the refrigerant vapor, and simultaneously increasing the pressure and the temperature; the high-pressure high-temperature refrigerant vapor is pressed to the condenser 6, the refrigerant vapor with higher temperature exchanges heat with cooling water with lower temperature or air pumped out from the sample chamber 2 through the cold trap 7 in the condenser 6, the heat of the refrigerant is taken away by the water or the air and is condensed, and the refrigerant vapor is changed into liquid. The part of liquid is sent to the expansion valve 5, throttled into low-temperature and low-pressure liquid by the expansion valve 5 and enters the evaporator 3; the low-temperature and low-pressure refrigerant liquid in the evaporator 3 absorbs the heat of the compressed air to be vaporized, and the compressed air is condensed into a large amount of liquid water after being cooled; refrigerant vapor in the evaporator 3 is sucked away by the compressor 4, so that the refrigerant is subjected to four processes of compression, condensation, throttling and evaporation in the system, and the refrigerant and liquid and gas in the cold trap 7 are subjected to heat exchange, so that a cycle is completed, and meanwhile, the air in the sample chamber 2 and moisture between samples are subjected to heat exchange, so that the drying purpose is achieved. The vacuum pump 8 is closed, the controller controls the electromagnetic valve 9 to open the air inlet, external air slowly enters the freezing cavity 21 and enters the sample chamber 2 from the freezing cavity 21, the electromagnetic valve 9 can adjust and control the pressure relief size, so that the air filling speed is controlled, when the pressure sensor senses that the air pressure inside the sample chamber 2 reaches the degree of balancing with the external air pressure, the electromagnetic valve 9 is closed, finally the valve 19 on the U-shaped pipeline 20 is opened, the sample bottle connecting port 18 is unscrewed, the device is sequentially disassembled, a completely freeze-dried sample is taken out, the instrument is closed, and the freeze-drying experimental process is completed.

While the present invention has been described in detail and with reference to the accompanying drawings, it is not to be considered as limited to the scope of the invention. Various modifications and changes may be made by those skilled in the art without inventive step within the scope of the appended claims.

Claims

1. The utility model provides an prevent cross contamination formula freeze dryer which characterized in that: the refrigerator comprises a freezing chamber (1) and a sample chamber (2) which are connected up and down, wherein a freezing chamber (21) and a heat exchange system are arranged in the freezing chamber (1), the heat exchange system comprises a cold trap (7) wrapped outside the freezing chamber, the freezing chamber (21) is connected with a vacuum pump (8) through an external pipeline with an electromagnetic valve (9), and the electromagnetic valve (9) is electrically connected with a controller; the sample chamber (2) comprises an organic glass cover (17) and a sample frame (15) positioned in the organic glass cover (17), and a downward-inclined silica gel plate (12) is arranged on the inner side of the bottom of the organic glass cover (17); sample frame (15) bottom both sides are provided with annular card post (13), sample frame (15) bottom block has a baffle A (16), baffle A (16) below is provided with the baffle B that is located freezer (1) upper end, baffle B upper surface be provided with annular card post (13) complex draw-in groove (14), the lower extreme laminating of silica gel board (12) is in draw-in groove (14) outside.

2. The cross-contamination prevention freeze dryer of claim 1, wherein: the heat exchange system further comprises a compressor (4), a condenser (6), an expansion valve (5) and an evaporator (3) which are connected through pipelines, wherein the cold trap (7) is respectively connected with the evaporator (3) and the compressor (4), and the heat exchange system is electrically connected with the controller and the control panel.

3. The cross-contamination prevention freeze dryer of claim 1, wherein: baffle B's shape is the hollow cylinder of no bottom surface, baffle B's lower surface passes through round hole (10) and is connected with freezing chamber (21), the upper surface in freezing chamber (21) is provided with sealing washer (11), sealing washer (11) inner ring and baffle B's side swing joint, the inboard swing joint of sealing washer (11) outer loop and organic glass cover (17), the lower extreme laminating of silica gel board (12) is in sealing washer (11) inner ring is close to the direction of draw-in groove (14), and with sealing washer (11) inner ring keeps the interval more than 5 mm.

4. The cross-contamination prevention freeze dryer of claim 3, wherein: the refrigerating device is characterized in that a boss structure is arranged on the lower portion of the sealing ring (11), a positioning hole is formed in the upper portion of the refrigerating chamber (1), and the boss structure is movably connected with the positioning hole.

5. The cross-contamination prevention freeze dryer of claim 1, wherein: sample frame (15) including the pillar of both sides, pillar top welded pull rod (152) and with between the pillar a plurality of layers of supporter (151) of welded, be provided with a plurality of discs on supporter (151), the outer interval of pillar is less than baffle B's diameter.

6. The cross-contamination prevention freeze dryer of claim 1, wherein: a plurality of holes are uniformly formed in the baffle A (16), and the diameter of each hole is smaller than 5 mm.

7. The cross-contamination prevention freeze dryer of claim 1, wherein: the external pipeline is provided with a pressure sensor at one end inside the freezing cavity (21), and the pressure sensor is electrically connected with the controller.

8. The cross-contamination prevention freeze dryer of claim 1, wherein: the device is characterized in that a plurality of exhaust ports are uniformly formed in the upper end of the outer portion of the sample chamber (2), the exhaust ports are connected with a U-shaped pipeline (20), and a sample bottle connecting port (18) and a valve (19) are formed in the U-shaped pipeline (20).