CN206944586U - A kind of ex situ freeze dryer using cascade refrigeration system - Google Patents

A kind of ex situ freeze dryer using cascade refrigeration system Download PDF

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Publication number
CN206944586U
CN206944586U CN201720818717.6U CN201720818717U CN206944586U CN 206944586 U CN206944586 U CN 206944586U CN 201720818717 U CN201720818717 U CN 201720818717U CN 206944586 U CN206944586 U CN 206944586U
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China
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lyophilized
high temperature
circulation
freezing
chamber
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CN201720818717.6U
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Chinese (zh)
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张建立
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Henan Hanpin Technology Co ltd
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Henan Ruiling Technology Co Ltd
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Abstract

The utility model discloses a kind of ex situ freeze dryer using cascade refrigeration system, including casing, vavuum pump and lyophilized experimental system, refrigerating chamber and cryodesiccation chamber are provided with casing.Heater is provided with the cryodesiccation chamber, the vavuum pump is connected with cryodesiccation chamber.Cascade refrigeration system is additionally provided with casing, the cascade refrigeration system includes high-temperature refrigeration unit and cryogenic refrigeration unit.High-temperature refrigeration unit includes high temperature circulation compressor, high temperature circulation condenser, high temperature circulation expansion valve and evaporative condenser.Cryogenic refrigeration unit includes freeze cycle loop and lyophilized circulation loop.Lyophilized experimental system includes eggplant type bottle and communicating pipe, communicating pipe one end be sealedly and fixedly connected in lyophilized chamber outer wall, communicating pipe the other end seal and be removably connected with eggplant type bottle, eggplant type bottle is connected with cryodesiccation chamber by communicating pipe.The utility model can solve the problems, such as current laboratory using transfer distance when two machines of ultra low temperature freezer and freeze drier and space-consuming are big, layout is unreasonable farther out.

Description

A kind of ex situ freeze dryer using cascade refrigeration system
Technical field
It the utility model is related to a kind of technical field of refrigeration equipment, more particularly to a kind of non-original using cascade refrigeration system Position freeze dryer.
Background technology
Freeze dryer originates from the Vacuum Freezing & Drying Technology of the twenties in 19th century, experienced the fluctuating of decades and hovers Afterwards, made significant progress in 20th century last 20 years.Into 21 century, vacuum freeze drying technology relies on other drying means The advantages of incomparable, increasingly favored by people, except in medicine, biological products, food, blood product, active matter Outside matter field is used widely, it is using scale and field also in continuous expand.
Often combined at present in laboratory using ultra low temperature freezer and freeze drier and do lyophilized experiment, experimenter is first Sample is put into take out to place into freeze drier after the completion of ultra low temperature freezer freezing and continues to operate, because to use ultralow temperature Two machines of refrigerator and freeze drier, space-consuming is big, when being laid out unreasonable transfer distance farther out, because sample in transfer process Product and air, which carry out time of contact, longer may cause the unstable of frozen samples.Freeze dryer in situ is also used in laboratory, Freeze dryer in situ carries pre-freeze function, and sample can be completed in cryodesiccation chamber by being chilled to lyophilized overall process, and sample need not Transfer.But freeze dryer in situ, because being provided only with a cryodesiccation chamber, the sample after freezing can not do lyophilized experiment several times.
Utility model content
The purpose of this utility model is to provide a kind of ex situ freeze dryer using cascade refrigeration system, empty to solve to take Between it is big, when layout is unreasonable transfer distance farther out the problem of and freeze dryer in situ the problem of can not doing lyophilized experiment several times.
To achieve these goals, the utility model adopts the following technical scheme that:
A kind of ex situ freeze dryer using cascade refrigeration system, including casing, vavuum pump and lyophilized experimental system;It is described Refrigerating chamber and cryodesiccation chamber are provided with casing;Heater is provided with the cryodesiccation chamber, the vavuum pump is connected with cryodesiccation chamber.
Cascade refrigeration system is additionally provided with casing, the cascade refrigeration system includes high-temperature refrigeration unit and cryogenic refrigeration list Member;High temperature circulation condenser, high temperature circulation expansion valve, evaporative condenser and the high temperature that high-temperature refrigeration unit includes being sequentially connected in series follow Ring compressor, high temperature circulation compressor outlet are connected with high temperature circulation condenser inlet.Cryogenic refrigeration unit follows including freezing Loop back path and lyophilized circulation loop, freeze cycle loop include the low-temperature circulating compressor, evaporative condenser, freezing being sequentially connected in series Expansion valve and refrigerating evaporator, refrigerating evaporator outlet are connected with low-temperature circulating compressor inlet, and the refrigerating evaporator is set Put in refrigerating chamber;Low-temperature circulating compressor that lyophilized circulation loop includes being sequentially connected in series, evaporative condenser, lyophilized expansion valve and Lyophilized evaporator, lyophilized evaporator outlet are connected with low-temperature circulating compressor inlet, and the lyophilized evaporator is arranged on lyophilized It is indoor.
Lyophilized experimental system includes the eggplant type bottle being connected with cryodesiccation chamber, and eggplant type bottle is arranged on lyophilized chamber outer wall.
Preferably, freezing electromagnetism is provided with the freeze cycle loop between evaporative condenser outlet and freezing expansion valve Valve;Evaporative condenser is provided with lyophilized magnetic valve between exporting and freezing expansion valve in the lyophilized circulation loop.
Preferably, it is provided with freezing and filtering between evaporative condenser outlet and freezing magnetic valve in the freeze cycle loop Device;Evaporative condenser is provided with lyophilized filter between exporting and freezing magnetic valve in the lyophilized circulation loop.
Preferably, it is provided with height between the high-temperature refrigeration unit high temperature cycle condenser outlet and high temperature circulation expansion valve Warm recursive filter.
Preferably, the refrigerating evaporator is provided with the freezing electric heater of defrosting, and the lyophilized evaporator is provided with defrosting Lyophilized electric heater.
Preferably, the high-temperature refrigeration unit high temperature cycle condenser is provided with fan.
Preferably, the eggplant type bottle is connected by communicating pipe with cryodesiccation chamber, is provided with control eggplant type bottle the communicating pipe The rubber valve for connecting or isolating with cryodesiccation chamber.
Preferably, the heater is direct current electric heating plate.
The beneficial effects of the utility model are as follows:
1st, refrigerating chamber and cryodesiccation chamber are provided with the utility model casing, this structure saves the space-consuming of equipment, shortens Time of contact of the frozen samples in transfer process with air, and need to do several times and need are taken out after the sample tested has freezed The sample to be freezed is put into cryodesiccation chamber and continues lyophilized experiment, and remaining sample can continue to be placed in refrigerating chamber, be grasped to experimenter Provide convenient condition.
2nd, freeze cycle loop of the present utility model and lyophilized circulation loop use a low-temperature circulating compressor and one Evaporative condenser, therefore manufacturing cost and operating cost can be reduced, moreover it is possible to save the energy.
3rd, the utility model also includes lyophilized experimental system, and lyophilized experimental system includes eggplant type bottle and communicating pipe, communicating pipe One end is sealedly and fixedly connected in lyophilized chamber outer wall, communicating pipe the other end be sealedly and fixedly connected and have eggplant type bottle, eggplant type bottle and cryodesiccation chamber It is connected by communicating pipe.Lyophilized experimental system can do a small amount of lyophilized experiment, operation using the low temperature and subnormal ambient of refrigerating chamber Simplicity, energy-conserving and environment-protective.
4th, the utility model uses cascade refrigeration system, and the cylinder ratio of low-temperature circulating compressor uses Two-stage Compression Cryogenic compressor volume of cylinder is much smaller, and this is favourable to weight, the size for reducing complete machine, can also reduce energy consumption, and in system Normal pressure is kept, air is not easy to leak into system, made stable and safe.
5th, in freeze cycle loop of the present utility model between evaporative condenser outlet and freezing expansion valve it is, lyophilized to be recycled back to Evaporative condenser is equipped with magnetic valve between exporting and freezing expansion valve in road, therefore can independently be precisely controlled freeze cycle loop With the cryogenic temperature of lyophilized circulation loop.
6th, filter is equipped with freeze cycle loop of the present utility model, lyophilized circulation loop and high-temperature refrigeration unit, Filter plays a part of removing the impurity and moisture in refrigerant, ensures equipment normal operation, moreover it is possible to increase the use of equipment Life-span.
7th, refrigerating evaporator of the present utility model is provided with the freezing electric heater of defrosting, freezes evaporator and is provided with defrosting Lyophilized electric heater, electric heater can defrost to evaporator in time, therefore reduce the thermal resistance of evaporator and each indoor air, Refrigerating efficiency can be improved, save energy consumption.
Brief description of the drawings
Fig. 1 is structural representation of the present utility model.
Fig. 2 is cascade refrigeration system figure of the present utility model.
Fig. 3 is the partial enlarged drawing of lyophilized experimental system of the present utility model.
Shown in figure:1- low-temperature circulating compressors, 2- high temperature circulation compressors, 3- refrigerating evaporators, 4- freeze evaporator, 5- freezes expansion valve, and 6- freezes magnetic valve, and 7- freezes filter, 8- freezing expansion valves, 9- freezing magnetic valves, 10- freezing and filterings Device, 11- evaporative condensers, 12- high temperature circulation expansion valves, 13- high temperature circulation filters, 14- high temperature circulation condensers, 15- wind Fan, 16- high-temperature refrigeration units, 17- cryogenic refrigeration units, 18- refrigerating chambers, 19- cryodesiccation chamber, 20- direct current electric heating plates, 21- eggplants Type bottle, 22- rubber valves, 23- vavuum pumps, 24- communicating pipes, 25- freeze experimental system.
Embodiment
Embodiment of the present utility model is further illustrated below in conjunction with accompanying drawing.
As depicted in figs. 1 and 2, a kind of ex situ freeze dryer using cascade refrigeration system, including casing, the and of vavuum pump 23 Lyophilized experimental system 25;Refrigerating chamber 18 and cryodesiccation chamber 19 are provided with the casing;Direct current electrical heating is provided with the cryodesiccation chamber 19 Disk 20, direct current electric heating plate 20 provide water sublimed during needed for heat.The vavuum pump 23 is connected with cryodesiccation chamber 19.
Cascade refrigeration system is additionally provided with casing, the cascade refrigeration system includes high-temperature refrigeration unit 16 and cryogenic refrigeration Unit 17;High-temperature refrigeration unit 16 includes high temperature circulation compressor 2, high temperature circulation condenser 14, the and of high temperature circulation expansion valve 12 Evaporative condenser 11, the high temperature circulation compressor 2, high temperature circulation condenser 14, high temperature circulation expansion valve 12 and evaporative condenser Device 11 passes sequentially through connecting tube and is in series to form high temperature circulation loop.Cryogenic refrigeration unit 17 includes freeze cycle loop and freezed Circulation loop, freeze cycle loop include evaporative condenser 11, freezing expansion valve 8, refrigerating evaporator 3 and low-temperature circulating compressor 1, the evaporative condenser 11, freezing expansion valve 8, refrigerating evaporator 3 pass sequentially through connecting tube with low-temperature circulating compressor 1 and mutually gone here and there Connection;Lyophilized circulation loop includes evaporative condenser 11, lyophilized expansion valve 5, lyophilized evaporator 4 and low-temperature circulating compressor 1, described Evaporative condenser 11, lyophilized expansion valve 5, lyophilized evaporator 4 and low-temperature circulating compressor 1 pass sequentially through connecting tube and are in series.It is high Freezed in warm refrigeration unit 16 and cryogenic refrigeration unit 17 filled with refrigerant of different nature, high-temperature refrigeration unit 16 using medium temperature Agent, cryogenic refrigeration unit 17 use low-temperature refrigerant.The two units are connected by an evaporative condenser 11, and it was i.e. both The condenser of cryogenic refrigeration unit 17, and the evaporator of high-temperature refrigeration unit 16, i.e. refrigerant in high-temperature refrigeration unit 16 Evaporation be used for condensing refrigerant in cryogenic refrigeration unit 17.So, the heat that cryogenic refrigeration unit 17 absorbs is transmitted to high temperature Heat is transmitted to surrounding medium by the refrigerant of refrigeration unit 16, the refrigerant of high-temperature refrigeration unit 16 again.Cryogenic refrigeration unit 17 In freeze cycle loop freeze to refrigerating chamber 18, lyophilized circulation loop freezes to cryodesiccation chamber 19.
As shown in figures 1 and 3, freezing experimental system 25 includes eggplant type bottle 21 and communicating pipe 24, one end sealing of communicating pipe 24 It is fixedly connected on the outer wall of cryodesiccation chamber 19;The other end sealing of communicating pipe 24 is removably connected with eggplant type bottle 21, and eggplant type bottle 21 is with freezing Room 19 is connected by communicating pipe 24.It is provided with the rubber valve that control eggplant type bottle 21 is connected or isolated with cryodesiccation chamber 19 communicating pipe 24 22.The a small amount of laboratory sample freezed in advance is put into eggplant type bottle 21, can be lacked using the low temperature and subnormal ambient of cryodesiccation chamber 19 The lyophilized experiment of amount.
Evaporative condenser 11 is provided with freezing magnetic valve 9 between exporting and freezing expansion valve 8 in freeze cycle loop;It is lyophilized to follow Evaporative condenser 11 is provided with lyophilized magnetic valve 6 between exporting and freezing expansion valve 5 in loop back path.Freeze cycle loop is followed with lyophilized Loop back path is equipped with magnetic valve, by magnetic valve can independent control be turned on and off freeze cycle loop and lyophilized circulation loop, The cryogenic temperature in freeze cycle loop and lyophilized circulation loop can also be independently precisely controlled.Evaporative condenser in freeze cycle loop Freezing and filtering device 10 is provided between 11 outlets and freezing magnetic valve 9;The outlet of evaporative condenser 11 is with freezing in lyophilized circulation loop Lyophilized filter 7 is provided between magnetic valve 6.The high temperature cycle condenser 14 of high-temperature refrigeration unit 16 exports to be expanded with high temperature circulation High temperature circulation filter 13 is provided between valve 12.Filter can play a part of impurity screening and moisture.
Refrigerating evaporator 3 is provided with the freezing electric heater of defrosting, freezes the lyophilized electrical heating that evaporator 4 is provided with defrosting Device.The high temperature cycle condenser 14 of high-temperature refrigeration unit 16 is provided with fan 15.
The general principle of freeze-drying is the tri-state change based on water.Water has solid-state, liquid and gaseous state, and three kinds of states both may be used It can be coexisted again with mutually changing.When water is in three phase point(Temperature is 0.01 DEG C, water vapor pressure 610.5Pa)When, water, ice, water Steam three can coexist and mutually balance.Under high vacuum state, using sublimation principle, make the water in the material that freezes in advance Point, without the thawing of ice, directly it is removed with the distillation of ice state for water vapour, so as to reach the purpose of freeze-drying.Lyophilized system Product in it is spongy, without drying shrinkage, rehydration is fabulous, moisture content is few, can long-time storage and transport at normal temperatures after corresponding package. Because vacuum freeze drying has the advantages of other drying means are incomparable, therefore increasingly by people since technology appearance Favor, the application in terms of medicine, biological products and food is increasingly extensive.The biology system such as serum, strain, Chinese and western medical Product are mostly some bioactive substances, and Vacuum Freezing & Drying Technology also provides good solution route to preserve bioactivity.
This is using the new course of work:
When refrigerating chamber 18 works, low-temperature circulating compressor 1 and high temperature circulation compressor 2 start simultaneously.Low-temperature refrigerant leads to Cross after low temperature recycle compressor 1 compresses and enter after evaporative condenser 11 condenses by freezing filter 10, freezing magnetic valve 9 and cold Evaporated after freezing expansion valve 8 into refrigerating evaporator 3, the heat in evaporation process in the absorption refrigerating 18 of refrigerating evaporator 3 is realized Refrigerating chamber 18 freezes, and the low-temperature refrigerant after heat exchange flows back to low-temperature circulating compressor 1.Medium temperature refrigerant passes through high temperature circulation Compressor 2 enters after high temperature circulation condenser 14 condenses by high temperature recursive filter 13 and high temperature circulation expansion valve 12 after compressing Evaporated afterwards into evaporative condenser 11, the heat of the low-temperature refrigerant of cryogenic refrigeration unit 17 is taken away in evaporation process, by changing Medium temperature refrigerant after heat flows back to high temperature circulation compressor 2.
When cryodesiccation chamber 19 works, low-temperature circulating compressor 1 and high temperature circulation compressor 2 start simultaneously.Low-temperature refrigerant leads to Cross after low temperature recycle compressor 1 compresses and enter after evaporative condenser 11 condenses by freezing filter 7, lyophilized magnetic valve 6 and freezing Enter lyophilized evaporator 4 after dry expansion valve 5 to evaporate, the heat that evaporator 4 is absorbed in cryodesiccation chamber 19 is freezed in evaporation process and is realized Cryodesiccation chamber 19 freezes, and the low-temperature refrigerant after heat exchange flows back to the medium temperature refrigerant of low-temperature circulating compressor 1 and passes through high temperature circulation Compressor 2 enters after high temperature circulation condenser 14 condenses by high temperature recursive filter 13 and high temperature circulation expansion valve 12 after compressing Evaporated afterwards into evaporative condenser 11, the heat of the low-temperature refrigerant of cryogenic refrigeration unit 17 is taken away in evaporation process, by changing Medium temperature refrigerant after heat flows back to high temperature circulation compressor 2.The temperature of cryodesiccation chamber 19 opens vavuum pump 23 when reaching required temperature, At this moment cryodesiccation chamber 19 is in low-temperature negative-pressure state.
Experimenter opens freeze cycle loop, and sample is put into refrigerating chamber 18, is then turned on the lyophilized circulation of cryodesiccation chamber 19 Loop, vavuum pump 23 is opened when the temperature of cryodesiccation chamber 19 reaches required temperature the sample of freezing completion is put into cryodesiccation chamber 19, And close freezing magnetic valve 9, kept it turned on if freezing magnetic valve 9 when also having laboratory sample in refrigerating chamber 18.It is real Personnel are tested according to the observation to sample freeze-drying process, judge the time that direct current electric heating plate 20 is opened.Experimenter passes through observation Confirm to close lyophilized magnetic valve 6, direct current electric heating plate 20, low-temperature circulating compressor 1 and vavuum pump 23 after the completion of lyophilized operation.
The lyophilized circulation loop that cryodesiccation chamber 19 is first opened during a small amount of lyophilized experiment is done using eggplant type bottle 21, when cryodesiccation chamber 19 Temperature opens vavuum pump 23, the eggplant type equipped with sample that will be freezed in advance after the working stability of vavuum pump 23 when reaching required temperature The sealing of bottle 21 is fixedly mounted on the one end of communicating pipe 24, and opening rubber valve 22 makes to form negative pressure state, experimenter in eggplant type bottle 21 Confirm that experiment closes vavuum pump after terminating by observing.Eggplant type bottle can also be used to do lyophilized experiment during lyophilized circulation loop work, Operating procedure is same as above.
Above example is only to illustrative and not limiting the technical solution of the utility model, although with reference to above-described embodiment pair The utility model is described in detail, it will be understood by those within the art that:The utility model can still be entered Row modification or equivalent substitution, without departing from any modification or partial replacement of spirit and scope of the present utility model, it all should Cover among right of the present utility model.

Claims (8)

  1. A kind of 1. ex situ freeze dryer using cascade refrigeration system, it is characterised in that:Including casing, vavuum pump and lyophilized experiment System;Refrigerating chamber and cryodesiccation chamber are provided with the casing;Heater, the vavuum pump and cryodesiccation chamber's phase are provided with the cryodesiccation chamber Connection;
    Cascade refrigeration system is additionally provided with casing, the cascade refrigeration system includes high-temperature refrigeration unit and cryogenic refrigeration unit; High-temperature refrigeration unit includes high temperature circulation condenser, high temperature circulation expansion valve, evaporative condenser and the high temperature circulation being sequentially connected in series Compressor, high temperature circulation compressor outlet are connected with high temperature circulation condenser inlet;Cryogenic refrigeration unit includes freeze cycle Loop and lyophilized circulation loop, the low-temperature circulating compressor, evaporative condenser, freezing that freeze cycle loop includes being sequentially connected in series are swollen Swollen valve and refrigerating evaporator, refrigerating evaporator outlet are connected with low-temperature circulating compressor inlet, and the refrigerating evaporator is set In refrigerating chamber;Lyophilized circulation loop includes low-temperature circulating compressor, evaporative condenser, lyophilized expansion valve and the jelly being sequentially connected in series Dry evaporator, lyophilized evaporator outlet are connected with low-temperature circulating compressor inlet, and the lyophilized evaporator is arranged on cryodesiccation chamber It is interior;
    Lyophilized experimental system includes the eggplant type bottle being connected with cryodesiccation chamber, and eggplant type bottle is arranged on lyophilized chamber outer wall.
  2. 2. the ex situ freeze dryer according to claim 1 using cascade refrigeration system, it is characterised in that:The freezing follows Freezing magnetic valve is provided with loop back path between evaporative condenser outlet and freezing expansion valve;Evaporated in the lyophilized circulation loop cold Condenser is provided with lyophilized magnetic valve between exporting and freezing expansion valve.
  3. 3. the ex situ freeze dryer according to claim 1 using cascade refrigeration system, it is characterised in that:The freezing follows Evaporative condenser outlet is provided with freezing and filtering device in loop back path;Evaporative condenser outlet is provided with lyophilized in the lyophilized circulation loop Filter.
  4. 4. the ex situ freeze dryer according to claim 1 using cascade refrigeration system, it is characterised in that:The high temperature system High temperature circulation filter is provided between cold unit high temperature cycle condenser outlet and high temperature circulation expansion valve.
  5. 5. the ex situ freeze dryer according to claim 1 using cascade refrigeration system, it is characterised in that:The frozen steamed The freezing electric heater that device is provided with defrosting is sent out, the lyophilized evaporator is provided with the lyophilized electric heater of defrosting.
  6. 6. the ex situ freeze dryer according to claim 1 using cascade refrigeration system, it is characterised in that:The high temperature system Cold unit high temperature cycle condenser is provided with fan.
  7. 7. the ex situ freeze dryer according to claim 1 using cascade refrigeration system, it is characterised in that:The eggplant type bottle It is connected by communicating pipe with cryodesiccation chamber, the communicating pipe is provided with the rubber that control eggplant type bottle is connected or isolated with cryodesiccation chamber Valve.
  8. 8. the ex situ freeze dryer according to claim 1 using cascade refrigeration system, it is characterised in that:The heater For direct current electric heating plate.
CN201720818717.6U 2017-07-07 2017-07-07 A kind of ex situ freeze dryer using cascade refrigeration system Expired - Fee Related CN206944586U (en)

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CN201720818717.6U CN206944586U (en) 2017-07-07 2017-07-07 A kind of ex situ freeze dryer using cascade refrigeration system

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CN201720818717.6U CN206944586U (en) 2017-07-07 2017-07-07 A kind of ex situ freeze dryer using cascade refrigeration system

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CN206944586U true CN206944586U (en) 2018-01-30

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111520931A (en) * 2020-04-28 2020-08-11 冰山松洋生物科技(大连)有限公司 By CO2Ultra-low temperature refrigerator jointly used by auxiliary refrigeration equipment and binary cascade refrigeration system
CN116358204A (en) * 2023-03-31 2023-06-30 珠海格力电器股份有限公司 Compressor control method, storage box and storage medium

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111520931A (en) * 2020-04-28 2020-08-11 冰山松洋生物科技(大连)有限公司 By CO2Ultra-low temperature refrigerator jointly used by auxiliary refrigeration equipment and binary cascade refrigeration system
CN116358204A (en) * 2023-03-31 2023-06-30 珠海格力电器股份有限公司 Compressor control method, storage box and storage medium

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Effective date of registration: 20200609

Address after: No. 307-2, Chuangye building, No. 58, the second street, Zhengzhou area (Economic Development Zone), Henan Free Trade Zone, Zhengzhou City, Henan Province

Patentee after: Henan hanpin Technology Co.,Ltd.

Address before: Located in Henan province Zhengzhou City 450000 middle road Yang Newton international A building thirteen floor E District

Patentee before: HENAN RUILING TECHNOLOGY Co.,Ltd.

CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20180130