CN210569543U

CN210569543U - Freeze dryer

Info

Publication number: CN210569543U
Application number: CN201921714875.2U
Authority: CN
Inventors: 姜敏
Original assignee: Guangzhou Yuyantang Biotechnology Co ltd
Current assignee: Guangzhou Yuyantang Biotechnology Co ltd
Priority date: 2019-10-14
Filing date: 2019-10-14
Publication date: 2020-05-19
Anticipated expiration: 2029-10-14

Abstract

The utility model discloses a freeze dryer is used for dehydrating and drying solid matter, including drying cabinet, cold trap, heating device, circulating pump, compressor, vacuum pump and a plurality of pipeline, the drying cabinet passes through pipe connection cold trap, heating device and circulating pump, heating device is connected to the compressor, vacuum pump connection cold trap, the drying cabinet is placed and is remain the material of dehydration, and the compressor provides cold source to drying cabinet, and the cold trap collects the vapor that the material sublimated out, and heating device accelerates the sublimation speed of material, the vacuum pump provides vacuum environment for the material, the circulating pump makes refrigerating fluid and heating fluid circulate to realize the quick dehydration drying of material.

Description

Freeze dryer

Technical Field

The utility model relates to a freeze-drying equipment field especially relates to a freeze dryer.

Background

The freeze dryer is designed for the conventional vacuum drying and the conventional drying oven at present, is improved, upgraded and updated, utilizes the vacuum drying principle, enables the moisture in the materials to be changed into solid ice by freezing the wet materials to the eutectic point temperature, then directly sublimates the ice into vapor by heating the materials under the higher vacuum environment, and condenses the vapor by using a vapor condenser in a vacuum system, thereby achieving the purpose of dehydrating and drying the materials.

But the existing freeze dryer has unsatisfactory production efficiency, easy loss of a cold trap and no guarantee of the vacuum sterile state of the drying box after cleaning.

SUMMERY OF THE UTILITY MODEL

The to-be-solved technical problem of the utility model is to prior art's defect, provide one kind can improve production efficiency, cold-trap be difficult for still keeping vacuum sterile state's freeze dryer by the drying cabinet after loss and washing.

In order to solve the technical problem, the utility model adopts the following technical scheme: the utility model provides a freeze dryer for with solid matter dehydration, including drying cabinet, cold trap, heating device, circulating pump, compressor, vacuum pump and a plurality of pipeline, the drying cabinet passes through pipe connection cold trap, heating device and circulating pump, heating device is connected to the compressor, the cold trap of vacuum pump connection, the drying cabinet is placed and is waited the material of dehydration, and the compressor provides cold source to drying cabinet, and the cold trap collects the vapor that the material sublimated, and heating device accelerates the sublimation speed of material, the vacuum pump provides vacuum environment for the material, the circulating pump makes refrigerating fluid and heating fluid circulate to realize the quick dehydration of material.

Further, the drying cabinet is including guide arm and a plurality of sheet layer, the sheet layer is fixed in the drying cabinet through the guide arm in, the superiors' sheet layer is the temperature compensation board in the drying cabinet to ensure to arrange the material on the sheet layer in under the same environment of temperature.

Further, the sheet layer is hollow splint, and the sheet layer is inside to be equipped with the circulating pipe to guarantee that the temperature of sheet layer is even.

Further, a box trap butterfly valve is connected between the drying box and the cold trap and used for ensuring the sealing between the drying box and the cold trap, so that the material inlet and outlet of the drying box and the defrosting operation of the cold trap are carried out simultaneously.

Further, the drying box is connected with a CIP pressure pump, a first inlet valve and a second inlet valve, the CIP pressure pump is connected with a water tap, and the first inlet valve and the second inlet valve control water flow into the drying box, so that the drying box is flushed by controlling the water flow speed.

Furthermore, the drying box is sequentially connected with a box drain valve, a water ring pump valve and a water ring pump, the box drain valve discharges water in the drying box, the water ring pump pumps water further, and the water ring pump valve controls the on-off of the water ring pump, so that the water in the drying box is drained.

Further, the drying box is also connected with a vacuum regulating valve which flows sterile air and clean nitrogen into the drying box, thereby maintaining the vacuum environment of the drying box.

Furthermore, a trap butterfly valve is connected between the cold trap and the vacuum pump and used for controlling the vacuum pump to vacuumize the cold trap and the drying box.

Furthermore, the cold trap is connected with a trap drain valve, a defrosting valve and a trap overflow valve, the trap drain valve controls water in the cold trap to be discharged, the defrosting valve controls frost to be discharged out of the cold trap, and the trap overflow valve controls gas discharge.

Furthermore, the cold trap is also connected with a cold trap valve and a cold compensation valve, the cold trap valve and the cold compensation valve are connected with a pipeline of the compressor, the cold trap valve controls the opening and closing of the cold trap, and the cold compensation valve controls the gas of the compressor to flow into the cold trap.

Further, the compressor is connected with a prefreezing valve which controls the cold air flow of the compressor to enter the drying box.

The beneficial effects of the utility model reside in that:

(1) the position relations among the drying box, the cold trap, the heating device, the circulating pump, the compressor and the vacuum pump are skillfully arranged, so that a good circulating system is formed, and the production efficiency is improved;

(2) a box trap butterfly valve is arranged between the drying box and the cold trap, so that the drying box and the cold trap are mutually independent, the respective work is not interfered mutually, and the cold trap is further protected;

(3) a CIP pressure pump cleaning drying box is arranged, and a water ring pump is also arranged for pumping water in the drying box and the cold trap, so that the vacuum sterility in the freeze dryer is kept;

(4) different electric valves are arranged to control the drying box, the cold trap, the compressor and the vacuum pump to work, so that the production efficiency is improved, and the vacuum sterile environment of the freeze dryer is ensured.

Drawings

FIG. 1 is a connection diagram of the internal structure of the present invention;

FIG. 2 is a front view of the present invention;

fig. 3 is a top view of the present invention;

FIG. 4 is a view showing the internal structure of the drying box of the present invention;

FIG. 5 is a structural view of the plate layer and the circulation tube of the present invention;

in the figure, 1 is a drying box, 2 is a cold trap, 3 is a heating device, 4 is a circulating pump, 5 is a compressor, 6 is a vacuum pump, 7 is a pipeline, 8 is a guide rod, 9 is a slab layer, 10 is a circulating pipe, 11 is a box trap butterfly valve, 12 is a CIP pressure pump, 13 is a first inlet valve, 14 is a second inlet valve, 15 is a box drain valve, 16 is a water ring pump valve, 17 is a water ring pump, 18 is a vacuum regulating valve, 19 is a trap butterfly valve, 20 is a trap drain valve, 21 is a defrost valve, 22 is a trap overflow valve, 23 is a prefreezing valve, 24 is a cold trap valve, 25 is a cold compensation valve, 26 is a main drain valve, 27 is an electric control cabinet, 28 is a cold trap sight glass, 29 is a drying box sight glass, 30 is a box trap water outlet, 31 is a cold trap defrosting water inlet, and 32 is a cleaning water inlet.

Detailed Description

In this embodiment, refer to fig. 1-5, the utility model relates to a freeze dryer for with solid matter dehydration drying, including drying cabinet 1, cold trap 2, heating device 3, circulating pump 4, compressor 5, vacuum pump 6 and a plurality of pipeline 7, drying cabinet 1 passes through pipe connection cold trap 2, heating device 3 and circulating pump 4, heating device 3 is connected to compressor 5, cold trap 2 is connected to vacuum pump 6, drying cabinet 1 is placed and is waited the material of dehydration, and compressor 5 provides cold source to drying cabinet 1, and cold trap 2 collects the vapor that the material sublimated, and heating device 3 accelerates the sublimation speed of material, vacuum pump 6 provides the vacuum environment and gives the material, circulating pump 4 makes refrigerating fluid and heating fluid circulate to realize the quick dehydration drying of material.

Drying cabinet 1 is including guide arm 8 and a plurality of sheet layer 9, sheet layer 9 is fixed in drying cabinet 1 through guide arm 8 in, the superiors' sheet layer is the temperature compensation board in drying cabinet 1 to ensure to arrange the material on the sheet layer in under the same environment of temperature.

The sheet layer 9 is a hollow clamping plate, and a circulating pipe 10 is arranged inside the sheet layer, so that the temperature of the sheet layer is uniform.

A tank trap butterfly valve 11 is connected between the drying tank 1 and the cold trap 2 and used for ensuring the sealing between the drying tank 1 and the cold trap 2, so that the material inlet and outlet of the drying tank 1 and the defrosting operation of the cold trap 2 are carried out simultaneously.

The drying box 1 is connected with a CIP pressure pump 12, a first inlet valve 13 and a second inlet valve 14, the CIP pressure pump 12 is connected with a water tap, and the first inlet valve 13 and the second inlet valve 14 control water flow to the drying box 1, so that the water flow speed is controlled to flush the drying box 1.

The drying box 1 is sequentially connected with a box drain valve 15, a water ring pump valve 16 and a water ring pump 17, the box drain valve 15 discharges water in the drying box 1, the water ring pump 17 pumps water further, and the water ring pump valve 16 controls the water ring pump 17 to be switched on and switched off, so that the water in the drying box 1 is drained.

The cabinet 1 is also connected to a vacuum regulator valve 18 which allows sterile air and clean nitrogen to flow into the cabinet, thereby maintaining the vacuum environment of the cabinet 1.

And a trap butterfly valve 19 is connected between the cold trap 2 and the vacuum pump 6 and is used for controlling the vacuum pump to vacuumize the cold trap 2 and the drying box 1.

The cold trap 2 is connected with a trap drain valve 19, a defrosting valve 21 and a trap overflow valve 22, the trap drain valve 19 controls water in the cold trap 2 to be discharged, the defrosting valve 21 controls frost to be discharged out of the cold trap 2, and the trap overflow valve 22 controls gas to be discharged.

The cold trap 2 is further connected with a cold trap valve 24 and a cold compensation valve 25, the cold trap valve 24 and the cold compensation valve 25 are connected with a pipeline of the compressor 5, the cold trap valve 24 controls the opening and closing of the cold trap 2, and the cold compensation valve 25 controls the gas of the compressor 5 to flow into the cold trap 2.

The compressor 5 is connected to a prefreezing valve 23 which controls the flow of cold air from the compressor 5 into the drying box 1.

The tank drain valve 15 and the trap drain valve 20 are connected to a main drain valve 26, which main drain valve 26 controls all water flow out of the freeze dryer.

Referring to fig. 2 and 3, the freeze dryer is further provided with an electric control cabinet 27, a cold trap sight glass 28, a drying box sight glass 29, a box trap water outlet 30, a cold trap defrosting water inlet 31 and a cleaning water inlet 32.

Pre-freezing purpose: prefreezing is to freeze the product for sublimation under vacuum conditions. If the product is not frozen during pre-freezing, the product can be boiled and foamed during vacuum pumping, and has no certain shape; not only is energy and time wasted if the cold is too low, but survival rates are also reduced for certain active products. Therefore three data should be determined before pre-freezing: pre-freezing rate, pre-freezing temperature, pre-freezing time.

A. Pre-freezing rate: the speed of the pre-freezing speed has influence on the size of crystal grains in the frozen product, the survival rate of live bacteria and the sublimation speed. Generally, the slow freezing crystal grains are large, the product appearance is rough, viable bacteria are not easy to damage, but the sublimation speed is high, and the quick freezing is opposite to the sublimation speed.

B. Pre-freezing temperature: the pre-freezing temperature is slightly different according to different pre-freezing methods, and generally, the temperature of the plate layer is 5-10 ℃ lower than the eutectic point temperature of the product.

C. Pre-freezing time: the time required for pre-freezing will depend on the particular conditions. The general principle is that the product should be completely frozen in its parts. The temperature is recommended to be kept for 2 to 3 hours after the freezing point temperature is reached.

The pre-cooling of the cold trap is performed at the end of the pre-freezing of the product. When the temperature of the cold trap is reduced to below-60 ℃, the cold trap can be vacuumized.

Sublimation of the product:

1) first stage drying

When the pressure in the drying cabinet drops below 60Pa (depending on the product characteristics), the product is heated, providing energy for its sublimation, at a rate not exceeding the heat absorbed by the product during sublimation (i.e. no liquid water is present during sublimation). The pressure in the drying box must be maintained below the maximum allowable pressure (subject to convective transfer of heat not exceeding the heat absorbed by the product required for sublimation), and it is recommended that the temperature of the laminae not exceed the eutectic temperature of the product during the first sublimation. The end of the first stage drying can be concluded by the following phenomena:

a. the interface of the dried layer and the frozen layer reached the bottom of the bottle and disappeared.

b. The pressure of the freeze drying box and the pressure of the cold trap are close and are kept unchanged.

c. When the isolation valve is closed, the pressure in the tank rises at a rate similar to the leak rate of the lyophilization tank.

After the phenomenon occurs, the temperature is prolonged for at least 0.5 to 1 hour to thoroughly remove residual ice crystals in the product, and the product can be sublimated in the second stage.

2) Second stage drying

When the first stage drying of the product is finished and the second stage drying is carried out, the temperature of the product can be increased to be below the maximum temperature allowed by the product, the product is maintained for a certain time, the freeze-drying can be finished and the tamponade is carried out when the residual moisture content reaches a preset value.

The above description is only a preferred embodiment of the present invention, and should not be taken as limiting the scope of the invention, i.e. the present invention is intended to cover all equivalent variations and modifications within the scope of the present invention.

Claims

1. A freeze dryer for dehydrating and drying a solid material, characterized in that: including drying cabinet, cold trap, heating device, circulating pump, compressor, vacuum pump and a plurality of pipeline, the drying cabinet passes through pipe connection cold trap, heating device and circulating pump, heating device is connected to the compressor, the vacuum pump connection cold trap, the drying cabinet is placed and is waited the material of dehydration, and the compressor provides cold source to drying cabinet, and the water vapor that the material sublimated is collected to the cold trap, and heating device accelerates the sublimation speed of material, the vacuum pump provides vacuum environment for the material, the circulating pump makes refrigerating fluid and heating fluid circulate to realize the quick dehydration drying of material.

2. The lyophilizer according to claim 1, characterized in that: the drying cabinet is including guide arm and a plurality of sheet layer, the sheet layer is fixed in the drying cabinet through the guide arm in, the superiors' sheet layer is the temperature compensation board in the drying cabinet to ensure to arrange the material on the sheet layer in under the same environment of temperature.

3. The lyophilizer according to claim 2, characterized in that: the sheet layer is hollow splint, and the sheet layer is inside to be equipped with the circulating pipe to guarantee that the temperature of sheet layer is even.

4. The lyophilizer according to claim 1, characterized in that: and a box trap butterfly valve is connected between the drying box and the cold trap and used for ensuring the sealing between the drying box and the cold trap, so that the material inlet and outlet of the drying box and the defrosting operation of the cold trap are carried out simultaneously.

5. The lyophilizer according to claim 1, characterized in that: the drying box is connected with a CIP booster pump, a first inlet valve and a second inlet valve, the CIP booster pump is connected with a water tap, and the first inlet valve and the second inlet valve control water flow to enter the drying box, so that the water flow speed is controlled to flush the drying box.

6. The lyophilizer according to claim 5, characterized in that: the drying box is connected with a box drain valve, a water ring pump valve and a water ring pump in sequence, the box drain valve discharges water in the drying box, the water ring pump pumps water further, and the water ring pump valve controls the on-off of the water ring pump, so that the water in the drying box is emptied.

7. The lyophilizer according to claim 6, characterized in that: the drying cabinet is also connected to a vacuum regulating valve which flows sterile air and clean nitrogen gas into the drying cabinet, thereby maintaining the vacuum environment of the drying cabinet.

8. The lyophilizer according to claim 1, characterized in that: and a trap butterfly valve is connected between the cold trap and the vacuum pump and used for controlling the vacuum pump to vacuumize the cold trap and the drying box.

9. The lyophilizer according to claim 8, characterized in that: the cold trap is connected with a trap drain valve, a defrosting valve and a trap overflow valve, the trap drain valve controls water in the cold trap to be discharged, the defrosting valve controls frost to be discharged out of the cold trap, and the trap overflow valve controls gas discharge.

10. The lyophilizer according to claim 1, characterized in that: the compressor is connected with a prefreezing valve which controls the cold air flow of the compressor to enter the drying box.