CN214458054U - Sample extraction device and sample analysis system - Google Patents
Sample extraction device and sample analysis system Download PDFInfo
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- CN214458054U CN214458054U CN202120399434.9U CN202120399434U CN214458054U CN 214458054 U CN214458054 U CN 214458054U CN 202120399434 U CN202120399434 U CN 202120399434U CN 214458054 U CN214458054 U CN 214458054U
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Abstract
The utility model discloses a sample extraction element and sample analysis system, sample extraction element includes: the sample collection device comprises a rack, a sample collection module, a sample transfer module, at least two sample storage units for collection and at least one sample storage unit for detection, wherein the sample collection module, the sample transfer module, the at least two sample storage units for collection and the at least one sample storage unit for detection are all arranged on the rack; the system comprises a plurality of sample storage units for extraction, a sample extraction module, a sample storage module and a control module, wherein any two sample storage units for extraction are sequentially distributed along the X direction, the sample extraction module is sequentially operated in each sample storage unit for extraction along the X direction to extract a sample, and the last sample storage unit for extraction located along the X direction is used for storing the extracted sample; the sample transfer module is used for transferring the extracted sample to a sample storage unit for detection. The sample extraction device realizes the extraction and transfer of the sample in the same device, does not need other equipment or manpower to transfer the extracted sample, and improves the transfer efficiency; the cost and the risk of sample pollution are reduced; the manual operation amount is reduced, and the biological potential safety hazard is also reduced.
Description
Technical Field
The utility model relates to a sample extraction technical field, more specifically say, relate to a sample extraction element and sample analysis system.
Background
In the sample analysis process, the sample is usually extracted and purified first, and then the extracted and purified sample is subjected to detection and analysis. Specifically, the sample is extracted to the storage well plate by the sample extraction device, and then the sample in the storage well plate is transferred to the detection well plate, that is, the extracted sample is transferred to the detection well plate.
At present, the sample that mainly adopts the staff manual or another device of sampling will deposit in the orifice plate shifts to the detection orifice plate, and is consuming time longer, and efficiency is lower, can't satisfy large batch sample analysis demand.
In addition, if manual work is adopted, the operation is frequent, and the fatigue is easy to occur after long-time operation; strict biological protection is required in the transfer process, and certain biological safety hidden danger also exists. If another device is adopted, the risk of sample pollution exists, and the cost is higher.
In addition, the existing sample extraction device can extract 8-96 samples at a time, has less flux and cannot meet the requirement of large-batch sample extraction.
In summary, how to complete sample extraction and sample transfer to a detection pore plate to improve efficiency and meet the requirement of large-batch sample analysis is a problem to be solved urgently by those skilled in the art.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a sample extraction element to raise the efficiency, be convenient for satisfy large batch sample analysis demand. Another object of the present invention is to provide a sample analysis system having the above sample extraction device.
In order to achieve the above object, the present invention provides the following technical solutions:
a sample extraction device, comprising: the sample collection device comprises a rack, a sample extraction module, a sample transfer module, at least two sample storage units for extraction and at least one sample storage unit for detection, wherein the sample extraction module, the sample transfer module, the at least two sample storage units for extraction and the at least one sample storage unit for detection are all arranged on the rack;
the sample extraction modules are sequentially operated in each sample storage unit for extraction along the X direction to extract a sample, and the last sample storage unit for extraction along the X direction is used for storing the extracted sample; the sample transfer module is used for transferring the extracted sample to the sample storage unit for detection.
Preferably, the sample extraction device further comprises: the device comprises a gun head storage device for storing gun heads, wherein the sample storage unit for detection and the gun head storage device are sequentially distributed along the X direction;
the sample transfer module can suck the gun head from the gun head storage device and can suck and release a sample through the gun head, and the sample transfer module and the sample extraction module are both movably arranged on the rack along the X direction.
Preferably, an X-direction linear sliding table is fixed on the rack, the sample transfer module and the sample extraction module are both fixed on a sliding part of the X-direction linear sliding table, and the sample storage unit for extraction, the sample storage unit for detection and the lance head storage device are sequentially distributed along the X direction.
Preferably, the sample storage unit for detection comprises at least two detection storage pore plates which are sequentially distributed along the Y direction, and the gun heads sucked by the sample transfer module correspond to the detection storage pores on the detection storage pore plates one to one;
the sample extraction device further comprises a Y-direction linear sliding table fixed on a sliding part of the X-direction linear sliding table, and the sample transfer module is fixed on the sliding part of the Y-direction linear sliding table.
Preferably, the sample extraction device further comprises a waste material storage device for storing the used lance tip, and the waste material storage device and the lance tip storage device are positioned on the same side of the sample storage unit for detection;
the machine frame is provided with an operating platform, and the extracting sample storage unit, the detecting sample storage unit, the gun head storage device and the waste storage device are integrated on the operating platform.
Preferably, the sample storage unit for detection is located at the bottom side of the sample transfer module;
the sample transfer module includes: the pipetting pump assembly is movably arranged on the first support plate along the Z direction;
the first support plate is movably arranged on the rack along the X direction, the pipetting pump assembly can suck and release the gun head and can suck and release a sample through the gun head, and the Z direction is the height direction of the rack.
Preferably, the sample storage unit for extraction is located at the bottom side of the sample extraction module;
the sample extraction module comprises: the second support plate is provided with an extraction component which can be movably arranged on the second support plate along the Z direction; the second supporting plate is movably arranged on the rack along the X direction, and the Z direction is the height direction of the rack.
Preferably, the extraction assembly comprises a magnetic rod sleeve assembly and a magnetic rod assembly which are matched, and the magnetic rod sleeve assembly and the magnetic rod assembly are both capable of moving along the Z direction and are capable of relatively moving along the Z direction.
Preferably, the second support plate is fixed with a first Z-direction linear sliding table, the magnetic rod sleeve assembly is fixed on a sliding part of the first Z-direction linear sliding table, the magnetic rod sleeve assembly is fixed with a second Z-direction linear sliding table, and the magnetic rod assembly is fixed on a sliding part of the second Z-direction linear sliding table.
Preferably, the sample extraction device further comprises a shielding module, wherein the shielding module comprises a shielding plate movably arranged on the rack along the X direction, and the shielding plate can receive liquid dripped from the sample extraction module and liquid dripped from the sample transfer module.
Preferably, the shielding module further comprises a third supporting plate, and the shielding plate is movably arranged on the third supporting plate along the X direction; the third support plate and the sample extraction module are movably arranged on the rack along the X direction, and the third support plate and the sample extraction module synchronously move along the X direction.
Preferably, the extraction sample storage unit comprises at least two extraction storage pore plates which are sequentially distributed along the Y direction; and/or the sample storage unit for detection comprises at least two detection storage pore plates which are sequentially distributed along the Y direction; wherein the X direction is perpendicular to the Y direction.
Preferably, the sample extraction device further comprises a negative pressure module for making the operation environment of the sample extraction module and the sample transfer module be negative pressure.
Based on the sample extraction element that above-mentioned provided, the utility model also provides a sample analysis system, this sample analysis system include sample extraction element, sample extraction element is above-mentioned arbitrary sample extraction element.
The utility model provides a sample extraction device, through transferring the module integration in sample extraction device with the sample, realized accomplishing sample extraction and sample transfer in same device, need not other equipment to transfer the sample that draws, improved transfer efficiency, be convenient for satisfy large batch sample analysis demand; the cost and the risk of sample pollution are also reduced; moreover, the extracted sample does not need to be transferred manually, so that the manual operation amount is reduced, and the biological potential safety hazard is also reduced.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.
Fig. 1 is a schematic structural diagram of a sample extraction device according to an embodiment of the present invention;
fig. 2 is a schematic structural diagram of a platform module in the sample extraction device according to an embodiment of the present invention;
fig. 3 is a schematic structural diagram of a motion module in the sample extraction device according to an embodiment of the present invention;
fig. 4 is a schematic structural diagram of a sample extraction module in a sample extraction device according to an embodiment of the present invention;
fig. 5 is a schematic structural diagram of a sample transfer module in a sample extraction device according to an embodiment of the present invention;
fig. 6 is a schematic structural diagram of a shielding module in the sample extraction device according to an embodiment of the present invention;
fig. 7 is a schematic structural diagram of a negative pressure module in a sample extraction device according to an embodiment of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
As shown in fig. 1, the embodiment of the present invention provides a sample extraction device, including: a rack 700, a specimen extraction module 300, a specimen transfer module 400, at least two specimen storage units for extraction, and at least one specimen storage unit 105 for detection, all disposed on the rack 700.
In the sample extraction device, any two sample storage units for extraction are sequentially distributed along the X direction, the sample extraction module 300 is sequentially operated in each sample storage unit for extraction along the X direction to extract a sample, and the last sample storage unit for extraction along the X direction is used for storing the extracted sample; the sample transfer module 400 is used to transfer the extracted sample to the detection sample storage unit 105. The detection sample storage unit 105 can be directly placed on a sample detection device to perform sample detection.
Sample extraction is a technique well known to the skilled person, and the specific process of sample extraction is selected according to the actual needs. The number of the sample storage units for extraction is selected according to the specific process of sample extraction. In order to improve the versatility, it is preferable that the number of the extraction sample storage units is at least three. The number of the extraction sample storage units is four, and the four storage units are a first extraction sample storage unit 101, a second extraction sample storage unit 102, a third extraction sample storage unit 103, and a fourth extraction sample storage unit 104. Among them, a first extraction sample storage unit 101, a second extraction sample storage unit 102, a third extraction sample storage unit 103, and a fourth extraction sample storage unit 104 are distributed in order along the X direction, the third extraction sample storage unit 103 is a spare unit, and the fourth extraction sample storage unit 104 is used for storing the extracted samples, as shown in fig. 2.
In practical applications, the functions of the first extraction sample storage unit 101, the second extraction sample storage unit 102, and the third extraction sample storage unit 103 may be interchanged, for example, the first extraction sample storage unit 101 is a spare unit. Therefore, the functions of the first extraction sample storage unit 101, the second extraction sample storage unit 102, and the third extraction sample storage unit 103 are selected according to actual needs, and are not limited to the above-described embodiments.
In the sample extraction device provided by this embodiment, the sample transfer module 400 is integrated in the sample extraction device, so that sample extraction and sample transfer are completed in the same device, and the extracted sample is transferred without other equipment, thereby improving transfer efficiency and facilitating the satisfaction of large-batch sample analysis requirements; the cost and the risk of sample pollution are also reduced; moreover, the extracted sample is not required to be transferred manually, so that the labor cost is reduced, and the biological potential safety hazard is also reduced.
In the sample extraction device, the specific type of the sample transfer module 400 is selected according to actual needs. Preferably, the sample extraction device further comprises a lance tip storage device 106 for storing lance tips, and the detection sample storage unit 105 and the lance tip storage device 106 are sequentially distributed along the X direction, as shown in fig. 2. The sample transfer module 400 described above is capable of suctioning tips from the tip storage device 106 and of suctioning and releasing samples via the tips.
In order to facilitate the sample extraction and the sample transfer, the sample transfer module 400 and the sample extraction module 300 are preferably movably disposed on the rack 700 in the X direction.
In order to simplify the structure, the X-direction linear sliding table 201 is fixed to the rack 700, and the sample transfer module 400 and the sample extraction module 300 are both fixed to a sliding member of the X-direction linear sliding table 201. It will be appreciated that the sample transfer module 400 and the sample extraction module 300 both move with the movement of the slide, i.e. the sample transfer module 400 and the sample extraction module 300 both move synchronously in the X-direction.
It should be noted that the X-direction linear sliding table 201 is an existing component, and the X-direction linear sliding table 201 mainly includes: the X-direction driving component drives the sliding piece to move along the X direction.
In order to reduce the stroke, it is preferable that the above-described extraction sample storage unit, the detection sample storage unit 105, and the tip storage device 106 are distributed in this order in the X direction, as shown in fig. 2.
In practical applications, the extraction sample storage unit, the detection sample storage unit 105, and the tip storage device 106 may be distributed in other directions, and are not limited to the above embodiments.
In order to increase the sample transfer amount, the sample storage unit 105 for detection includes at least two detection storage well plates 1010 sequentially distributed along the Y direction, and each detection storage well plate 1010 has at least two detection storage wells, as shown in fig. 2.
Preferably, there are four detection storage well plates 1010, and there are 96 detection storage wells on each detection storage well plate 1010. Of course, the number of the detection storage well plates 1010 and the detection storage holes thereof may be other, and is not limited to the above.
The tips sucked by the sample transfer module 400 correspond to the detecting and storing holes on the detecting and storing hole plate 1010 one by one, and the sample transfer module 400 is movably disposed on the rack 700 along the Y direction.
Further, when the X-direction linear sliding table 201 is fixed to the rack 700, the sample extraction apparatus further includes a Y-direction linear sliding table 202, the Y-direction linear sliding table 202 is fixed to a slide member of the X-direction linear sliding table 201, and the sample transfer module 400 is fixed to a slide member of the Y-direction linear sliding table 202. At this time, the sample transfer module 400 is fixed to the slide of the X-direction linear slide table 201 by the Y-direction linear slide table 202.
The Y-direction linear slide table 202 is an existing component, and the Y-direction linear slide table 202 mainly includes a slider and a Y-direction driving member that drives the slider to move in the Y direction.
In order to improve the stability, the sample extraction device further comprises an X-guide rail 204 fixed on the rack 700, the X-guide rail 204 is arranged in parallel with the X-linear sliding table 201, the X-guide rail 204 and the X-linear sliding table 201 are respectively positioned at two ends of the Y-linear sliding table 202, and the Y-linear sliding table 202 is in sliding fit with the X-guide rail 204.
In order to fix the Y-direction linear sliding table 202, it is preferable that a connecting plate 205 is fixed to a slider of the X-direction linear sliding table 201, and the Y-direction linear sliding table 202 is fixed to the connecting plate 205. Specifically, one end of the connecting plate 205 is fixed to the slider of the X-direction linear slide table 201, and the other end of the connecting plate 205 is slidably fitted to the X-direction rail 204.
For maintenance, the frame 700 is provided with a mounting plate 203, and the X-direction guide 204 and the X-direction linear slide 201 are fixed to the mounting plate 203. Specifically, the above-described X-direction linear slide table 201, Y-direction linear slide table 202, mounting plate 203, X-direction guide 204, and connecting plate 205 are integrated into a motion module 200, as shown in fig. 3.
The specific position of the sample extraction device and the motion module 200 is selected according to actual needs. For improved stability, the motion module 200 is preferably located at the top of the frame 700.
The gun head needs to be discarded after being used once, and a new gun head is sucked when a sample needs to be transferred again. In order to facilitate collection of the used tips, the sample extraction device further comprises a waste material storage device 107, the waste material storage device 107 being adapted to store the used tips.
For reasonable layout, it is preferable that the scrap stocker 107 and the lance tip stocker 106 are located on the same side of the sample storage unit 105 for testing. Specifically, the extraction sample storage unit is located on one side of the detection sample storage unit 105, and the trash storage 107 and the lance tip storage 106 are located on the other side of the detection sample storage unit 105. Further, the scrap stocker 107 and the lance tip stocker 106 are sequentially distributed in the Y direction, as shown in fig. 2.
In the sample extraction apparatus, the pipette module 403 of the sample transfer module 400 is controlled to take a tip from the tip storage unit 106, move to the fourth extraction sample storage unit 104 to suck an extracted sample, transfer the extracted sample to the detection sample storage unit 105, and move the pipette module 403 to the waste storage unit 107 to discharge a used tip.
For the convenience of maintenance and management, it is preferable that the housing 700 is provided with an operation platform 108, and the extraction sample storage unit, the detection sample storage unit 105, the lance tip storage device 106, and the scrap storage device 107 are integrated on the operation platform 108. Specifically, the extraction sample storage unit, the detection sample storage unit 105, the lance head storage 106, the scrap storage 107, and the operation platform 108 are integrated into the platform module 100.
In the sample collection apparatus, the platform module 100 is disposed at the bottom of the rack 700 for easy operation, and the sample collection module 300 and the sample transfer module 400 are both disposed at the top of the platform module 100. Further, the motion module 200 is located at the top of the rack 700, and the sample extraction module 300 and the sample transfer module 400 are located between the platform module 100 and the motion module 200.
In the sample extraction device, the specific structure of the sample transfer module 400 is selected according to actual needs. Preferably, as shown in fig. 5, the detection sample storage unit 105 is located at the bottom side of the sample transfer module 400; the above-described sample transfer module 400 includes: a first support plate 401, a pipette pump assembly 403 movably disposed on the first support plate 401 in the Z direction; wherein, the first support plate 401 is movably disposed on the rack 700 along the X direction, the pipetting pump assembly 403 can suck and release the gun head and can suck and release the sample through the gun head, and the Z direction is the height direction of the rack 700.
It can be understood that, when the X-direction linear sliding table 201 is fixed to the frame 700, the first support plate 401 is fixed to a sliding member of the X-direction linear sliding table 201. When the Y-direction linear slide table 202 is fixed to the slider of the X-direction linear slide table 201, the first support plate 401 is fixed to the slider of the Y-direction linear slide table 202.
Further, a third Z-direction linear slide table 402 is fixed to the first support plate 401, and the pipette pump assembly 403 is fixed to a slider of the third Z-direction linear slide table 402.
The specific structure of the third Z-direction linear sliding table 402 is selected according to actual needs, which is not limited in this embodiment.
In the sample extraction device, the specific structure of the sample extraction module 300 is selected according to actual needs. Preferably, the above-mentioned extraction sample storage unit is located at the bottom side of the sample extraction module 300; the sample extraction module 300 includes: a second support plate 301, an extraction member movably disposed on the second support plate 301 in the Z-direction; wherein the second supporting plate 301 is movably disposed on the frame 700 along the X-direction, and the Z-direction is the height direction of the frame 700, as shown in fig. 4.
It can be understood that, when the X-direction linear sliding table 201 is fixed to the frame 700, the second support plate 301 is fixed to the sliding member of the X-direction linear sliding table 201.
Further, the second support plate 301 is fixed with a first Z-direction linear sliding table 302, and the extraction assembly is fixed on a sliding member of the first Z-direction linear sliding table 302.
The specific structure of the first Z-direction linear sliding table 302 is selected according to actual needs, which is not limited in this embodiment.
In order to facilitate the extraction of the sample, the extraction assembly is a magnetic rod extraction assembly. For the convenience of extraction, the extraction assembly preferably comprises a magnetic rod sleeve assembly 305 and a magnetic rod assembly 304 which are matched, and the magnetic rod sleeve assembly 305 and the magnetic rod assembly 304 can move along the Z direction and can relatively move along the Z direction.
Specifically, as shown in fig. 4, the first Z-direction linear sliding table 302 is fixed to the second support plate 301, the bar magnet sleeve assembly 305 is fixed to the slider of the first Z-direction linear sliding table 302, the second Z-direction linear sliding table 303 is fixed to the bar magnet sleeve assembly 305, and the bar magnet assembly 304 is fixed to the slider of the second Z-direction linear sliding table 303.
In the above described extraction assembly, both the independent up and down movement of the bar magnet assembly 304 along Z is achieved so that the bar magnet can be inserted into the bar magnet sleeve, and the up and down movement of the bar magnet assembly 304 along Z along with the bar magnet sleeve assembly 305 is achieved. The sample extraction and purification are realized by controlling the sample extraction module 300 to move between the four sample storage units for extraction along the X direction and matching the magnetic rod assembly 304 with the magnetic rod sleeve assembly 305 to move along the Z direction.
It should be noted that the above-mentioned extraction module is designed and manufactured based on the magnetic jacket method nucleic acid extraction. In the nucleic acid extraction process, magnetic beads are used as carriers, and the whole extraction and purification process of the sample is completed by controlling the sample extraction module 300 according to the principle that the magnetic beads adsorb the nucleic acid under high salt and low pH value and are separated from the nucleic acid under low salt and high pH value.
In an actual application process, the extraction component may also be selected as another structure or type, which is not limited in this embodiment.
In the sample collection device, when the sample collection module 300 is separated from the collection sample storage unit, a liquid, such as a sample or a liquid for collecting a sample, remains on the outer wall of the collection unit, and the liquid may drip into the collection sample storage unit, thereby causing contamination. Accordingly, when the sample transfer module 400 sucks the sample, the sample transfer module 400 may drip the sample, which may cause contamination.
Although the probability of the liquid dripping is small, in order to improve the extraction quality, the sample extraction device further comprises a shielding module 500, the shielding module 500 comprises a shielding plate 501 movably arranged on the rack 700 along the X direction, and the shielding plate 501 can receive the liquid dripping from the sample extraction module 300 and the liquid dripping from the sample transfer module 400, as shown in FIG. 6.
It will be appreciated that when the shutter 501 receives liquid dripping from the sample extraction module 300, the shutter 501 is located directly below the sample extraction module 300; when the shutter 501 receives liquid dripping from the sample transfer module 400, the shutter 501 is located directly below the sample transfer module 400.
In practical applications, when the shielding plate 501 is located directly below the sample extraction module 300, the shielding plate 501 is not located directly below the sample transfer module 400; when the shutter 501 is located directly below the sample transfer module 400, the shutter 501 is not directly below the sample extraction module 300. Alternatively, when the shutter 501 is located directly below the sample extraction module 300, it is also located directly below the sample transfer module 400.
To reduce the volume of the shutter 501, when the shutter 501 is located directly below the sample extraction module 300, the shutter 501 is not directly below the sample transfer module 400; when the shutter 501 is located directly below the sample transfer module 400, the shutter 501 is not directly below the sample extraction module 300.
In order to reduce the stroke of the shielding plate 501 and facilitate shielding, as shown in fig. 6, the shielding module 500 further includes a third supporting plate 504, and the shielding plate 501 is movably disposed on the third supporting plate 504 along the X direction; wherein the third support plate 504 and the sample extraction module 300 are both movably disposed on the rack 700 along the X-direction, and the third support plate 504 and the sample extraction module 300 move synchronously along the X-direction.
Specifically, when the X-direction linear sliding table 201 is fixed to the frame 700, the third support plate 504 is fixed to a slider of the X-direction linear sliding table 201.
The shielding plate 501 is movably disposed on the third supporting plate 504 in the X direction, for example, the shielding plate 501 is movably disposed on the third supporting plate 504 in the X direction by a synchronous belt transmission mechanism, and the synchronous belt transmission mechanism includes: a drive pulley, a driven pulley, a belt 503 wound around the drive pulley and the driven pulley, and a driver 502 for driving the drive pulley to rotate; wherein, the shielding plate 501 is fixed on the belt 503.
The driver 502 may be a motor or an air cylinder. Of course, the shielding plate 501 may be movably disposed on the third supporting plate 504 along the X direction by a rack-and-pinion mechanism or other mechanisms, and is not limited to the above definition.
In the sample collection device, the specific configurations of the collection sample storage means and the detection sample storage means 105 are selected according to actual needs. In order to increase the throughput, it is preferable that the extraction sample storage unit includes at least two extraction storage well plates 109 sequentially distributed in the Y direction, and the number of the extraction storage well plates 109 is at least two; and/or the sample storage unit 105 for detection comprises at least two detection storage pore plates 1010 which are sequentially distributed along the Y direction, and at least two detection storage pores are arranged on the detection storage pore plates 1010; wherein the X direction is perpendicular to the Y direction.
In the practical application process, in order to facilitate extraction, the sample storage unit for extraction has a heating and heat preservation function. In order to ensure the quality of the extracted sample, the detection sample storage unit 105 has a cooling and heat-preserving function.
The specific structure for realizing the heating and heat-insulating functions and the refrigerating and heat-insulating functions is selected according to actual needs, and the embodiment does not limit the structure.
The sample extraction process can reduce biological pollution and increase negative pressure function. In order to provide a negative pressure environment, the sample extraction device further comprises a negative pressure module 600 for making the operating environment of the sample extraction module 300 and the sample transfer module 400 be negative pressure.
Specifically, as shown in fig. 7, the negative pressure module 600 includes: a negative pressure chamber 602 having an inlet and an outlet, a filter membrane 601 disposed at the inlet of the negative pressure chamber 602, a blower 603 disposed in the negative pressure chamber 602; wherein the inlet of the negative pressure chamber 602 faces the extraction-use sample storage unit and the detection-use sample storage unit 105. The type of the fan 603 is selected according to actual needs, for example, the fan 603 is a centrifugal fan, which is not limited in this embodiment.
It will be appreciated that the outlet of the negative pressure chamber 602 is directed towards the environment outside the sample extraction device. In fig. 7, the arrow line indicates the air flow direction.
In an actual application process, the negative pressure module 600 may also be selected to have another structure, which is not limited in this embodiment.
Based on the sample extraction device provided in the foregoing embodiment, the present embodiment further provides a sample analysis system, which includes the sample extraction device described in the foregoing embodiment.
Since the sample extraction device provided in the above embodiment has the above technical effects, and the sample analysis system includes the above sample extraction device, the above sample analysis system also has corresponding technical effects, and details are not repeated herein.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (14)
1. A sample extraction device, comprising: a rack (700), a sample extraction module (300), a sample transfer module (400), at least two sample storage units for extraction, and at least one sample storage unit (105) for detection, all disposed on the rack (700);
any two extraction sample storage units are sequentially distributed along the X direction, the sample extraction module (300) is sequentially operated in each extraction sample storage unit along the X direction to extract a sample, and the extraction sample storage unit located at the last along the X direction is used for storing the extracted sample; the sample transfer module (400) is configured to transfer the extracted sample to the detection sample storage unit (105).
2. The sample extraction device of claim 1, further comprising: the device comprises a gun head storage device (106) for storing gun heads, wherein the sample storage unit (105) for detection and the gun head storage device (106) are sequentially distributed along the X direction;
the sample transfer module (400) can suck the gun head from the gun head storage device (106) and can suck and release a sample through the gun head, and the sample transfer module (400) and the sample extraction module (300) are both movably arranged on the rack (700) along the X direction.
3. The sample extraction device according to claim 2, wherein an X-direction linear sliding table (201) is fixed on the rack (700), the sample transfer module (400) and the sample extraction module (300) are fixed on a sliding member of the X-direction linear sliding table (201), and the sample storage unit for extraction, the sample storage unit for detection (105) and the lance tip storage device (106) are sequentially distributed along the X-direction.
4. The sample extraction device of claim 3,
the sample storage unit (105) for detection comprises at least two detection storage pore plates (1010) which are sequentially distributed along the Y direction, and the gun heads sucked by the sample transfer module (400) correspond to the detection storage pores on the detection storage pore plates (1010) one by one;
the sample extraction device further comprises a Y-direction linear sliding table (202) fixed on a sliding part of the X-direction linear sliding table (201), and the sample transfer module (400) is fixed on the sliding part of the Y-direction linear sliding table (202).
5. The sample extraction device according to claim 2, further comprising a waste storage device (107) for storing the used lance tip, the waste storage device (107) and the lance tip storage device (106) being located on the same side of the detection sample storage unit (105);
wherein the rack (700) is provided with an operating platform (108), and the sample storage unit for extraction, the sample storage unit for detection (105), the lance tip storage device (106) and the waste storage device (107) are all integrated on the operating platform (108).
6. The sample extraction device of claim 2,
the sample storage unit (105) for detection is located at the bottom side of the sample transfer module (400);
the sample transfer module (400) comprises: a first support plate (401), a pipetting pump assembly (403) movably arranged on the first support plate (401) along the Z direction;
the first support plate (401) is movably arranged on the rack (700) along the X direction, the pipetting pump assembly (403) can suck and release a gun head and can suck and release a sample through the gun head, and the Z direction is the height direction of the rack (700).
7. The sample extraction device of claim 1,
the sample storage unit for extraction is located at the bottom side of the sample extraction module (300);
the sample extraction module (300) comprises: a second support plate (301) on which an extraction assembly is movably disposed in a Z-direction; wherein the second support plate (301) is movably arranged on the frame (700) along an X direction, and a Z direction is a height direction of the frame (700).
8. The sample extraction device according to claim 7, wherein the extraction assembly comprises a magnetic rod sleeve assembly (305) and a magnetic rod assembly (304) which are used in cooperation, and wherein the magnetic rod sleeve assembly (305) and the magnetic rod assembly (304) are both movable in the Z direction and are capable of relative movement in the Z direction.
9. The sample extraction device according to claim 8, wherein the second support plate (301) is fixed with a first Z-direction linear sliding table (302), the magnetic rod sleeve assembly (305) is fixed on a sliding part of the first Z-direction linear sliding table (302), the magnetic rod sleeve assembly (305) is fixed with a second Z-direction linear sliding table (303), and the magnetic rod assembly (304) is fixed on a sliding part of the second Z-direction linear sliding table (303).
10. The sample extraction device according to claim 1, further comprising a shutter module (500), wherein the shutter module (500) comprises a shutter plate (501) movably arranged on the rack (700) in the X-direction, and wherein the shutter plate (501) is capable of receiving both the liquid dripping from the sample extraction module (300) and the liquid dripping from the sample transfer module (400).
11. The sample extraction device according to claim 10, wherein the shutter module (500) further comprises a third support plate (504), the shutter (501) being movably arranged on the third support plate (504) in the X-direction; wherein the third support plate (504) and the sample extraction module (300) are both movably arranged on the rack (700) along the X-direction, and the third support plate (504) and the sample extraction module (300) move synchronously along the X-direction.
12. The sample extraction device of claim 1,
the extraction sample storage unit comprises at least two extraction storage pore plates (109) which are sequentially distributed along the Y direction; and/or the sample storage unit (105) for detection comprises at least two detection storage pore plates (1010) which are distributed in sequence along the Y direction; wherein the X direction is perpendicular to the Y direction.
13. The sample extraction device according to any one of claims 1 to 12, further comprising a negative pressure module (600) for subjecting the sample extraction module (300) and the sample transfer module (400) to a negative pressure in an operating environment.
14. A sample analysis system comprising a sample extraction device, wherein the sample extraction device is as claimed in any one of claims 1 to 13.
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