CN214318296U - Medical nonwoven sheet and wound dressing - Google Patents
Medical nonwoven sheet and wound dressing Download PDFInfo
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- CN214318296U CN214318296U CN202020959419.0U CN202020959419U CN214318296U CN 214318296 U CN214318296 U CN 214318296U CN 202020959419 U CN202020959419 U CN 202020959419U CN 214318296 U CN214318296 U CN 214318296U
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Abstract
The utility model provides a medical non-woven fabrics sheet and wound dressing. Specifically, the medical nonwoven fabric sheet comprises a hydrophilic fiber layer in which the refractive index of the constituent material of the hydrophilic fibers is in the range of 1.3-1.7 and the diameter of the hydrophilic fibers is in the range of 30 to 500nm, the diameter of pores in the hydrophilic fiber layer is in the range of 0.06 to 1.0 μm and the porosity is in the range of 50-95%. The wound dressing comprises in sequence: a release layer; a medical non-woven fabric sheet; a transparent film layer; and a support layer. According to the technical scheme of the utility model non-woven fabrics sheet and wound dressing have good fungus nature, gas permeability and hydroscopicity of hindering to there is obvious transparency change after being moistened by liquid, change into transparent by opaque, thereby be convenient for observe the wound situation.
Description
Technical Field
The utility model relates to the field of medical equipment, specifically, relate to a medical non-woven fabrics sheet and a wound dressing.
Background
Chemotherapy is an important method of treating tumors, but drugs commonly used in chemotherapy cause damage to blood vessels. Therefore, to protect blood vessels, Central Venous Catheters (CVCs) and peripherally implanted central venous catheters (PICCs) are commonly used to inject drugs. This is because the blood flow rate in the central vein is high and the diameter of the central vein is large, so that it is possible to quickly dilute the drug and reduce the influence on the blood vessel. Central Venous Catheters (CVCs) and peripherally inserted central venous catheters (PICCs) avoid vascular erosion and repeated puncture injuries caused by irritant drugs, and these catheters can be preserved in the body for a long time, so that they are widely used for tumor therapy.
For central venous catheters and peripherally implanted central venous catheters, cleaning and care should be required once a week. During care after catheter placement, and particularly during first care after catheter placement, it is common to find exudate from deep veins at the wound site. There are high demands on wound dressings for the care of such wounds in terms of, for example, breathability, water absorption and bacteria resistance.
Therefore, the development of the wound dressing with good bacterium resistance, air permeability and water absorption is of great significance.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a non-woven fabrics sheet and a wound dressing, non-woven fabrics sheet and wound dressing have good fungus nature, gas permeability and the hydroscopicity of hindering to can become transparent after absorbing water, thereby be convenient for observe the wound situation.
Specifically, according to one aspect of the present invention, the present invention provides a medical nonwoven sheet comprising a hydrophilic fiber layer, a refractive index of a constituent material of hydrophilic fibers in the hydrophilic fiber layer being in the range of 1.3 to 1.7 and a diameter of the hydrophilic fibers being in the range of 30 to 500nm, a diameter of pores in the hydrophilic fiber layer being in the range of 0.06 to 1.0 μm and a porosity being in the range of 50 to 95%.
According to certain preferred embodiments of the present invention, the hydrophilic fiber layer has a grammage of 1 to 20g/m2Within the range of (1).
According to certain preferred embodiments of the present invention, the hydrophilic fibers are selected from one or more of the following: polyamide fibers, polyimide fibers, crosslinked polyvinyl alcohol fibers, crosslinked polyethylene oxide fibers, chitosan fibers, and polylactic acid fibers.
According to certain preferred embodiments of the present invention, the polyamide fibers are nylon 6 fibers.
According to certain preferred embodiments of the present invention, the hydrophilic fiber layer is an electrospun hydrophilic fiber layer.
According to certain preferred embodiments of the present invention, the thickness of the hydrophilic fiber layer is in the range of 20 to 200 μm.
According to another aspect of the present invention, the present invention provides a wound dressing, the wound dressing includes in proper order:
a release layer;
according to the medical non-woven fabric sheet, the medical non-woven fabric sheet is arranged on the release layer, and the edge of the medical non-woven fabric sheet is positioned in the edge of the release layer;
the transparent film layer is arranged above the medical non-woven fabric sheet and the release layer, and the edge of the transparent film layer exceeds the edge of the medical non-woven fabric sheet and is positioned in the edge of the release layer; and
the supporting layer covers at least one part of the transparent film layer and is attached to the release layer.
According to certain preferred embodiments of the present invention, the support layer has a through hole, thereby exposing the underlying transparent film layer.
According to certain preferred embodiments of the present invention, the edge of the transparent film layer is attached to the release layer through a hydrocolloid layer, which is located in the direction parallel to the plane of the wound dressing between the edge of the nonwoven fabric sheet and the edge of the release layer.
According to certain preferred embodiments of the present invention, the hydrocolloid layer is in contact with the nonwoven sheet.
According to the utility model discloses a non-woven fabrics sheet and wound dressing's advantage lies in having good fungus nature, gas permeability and the hydroscopicity of hindering to there is obvious transparency change after being moistened by liquid, change into transparent by opaque, thereby be convenient for observe the wound situation.
Drawings
Fig. 1 shows a schematic view of a medical nonwoven sheet according to an embodiment of the present invention;
fig. 2A shows a top view of a specific example of a wound dressing according to an embodiment of the present invention;
FIG. 2B shows a schematic cross-sectional view of the wound dressing along line a in FIG. 2A;
fig. 3A shows a top view of another specific example of a wound dressing according to an embodiment of the present invention;
FIG. 3B shows a schematic cross-sectional view of the wound dressing along line a in FIG. 3A;
fig. 4A shows a top view of yet another specific example of a wound dressing according to an embodiment of the present invention; and
fig. 4B shows a schematic cross-sectional view of the wound dressing along line a in fig. 4A.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings and specific embodiments. It will be appreciated that other embodiments are contemplated and may be made without departing from the scope or spirit of the present invention. The following detailed description is, therefore, not to be taken in a limiting sense.
During the first care after placement of a central catheter and a peripherally implanted central catheter, it is common to find exudate from deep veins at the wound site. Conventional wound dressings are not effective in treating the wound. In addition, since conventional wound dressings are opaque, medical personnel have to open the dressing to view the wound, which may cause secondary injury to the wound. Thus, medical personnel prefer a clear view of the puncture site. The inventor of the utility model finds that the non-woven fabric sheet with specific structural characteristics has good fungus resistance, gas permeability and hydroscopicity to there is apparent transparency change after being moistened by liquid, change into transparent by opaque, the medical staff of being convenient for just can look over the puncture point state under the condition of not opening the dressing.
Therefore, an object of the present invention is to provide a medical nonwoven sheet having good antibacterial properties, air permeability and water absorbability, and having a significant change in transparency after being wetted with a liquid, and being transparent, thereby facilitating observation of wound conditions.
Specifically, the present invention provides a medical nonwoven fabric sheet comprising a hydrophilic fiber layer in which the refractive index of the constituent material of the hydrophilic fibers is in the range of 1.3-1.7 and the diameter of the hydrophilic fibers is in the range of 30 to 500nm, the diameter of pores in the hydrophilic fiber layer is in the range of 0.06 to 1.0 μm and the porosity is in the range of 50-95%.
According to the technical scheme of the utility model, adopt the hydrophilic fiber layer to make the non-woven fabrics sheet. The hydrophilic property of the hydrophilic fiber layer facilitates the absorption of wound exudate and can provide a moisture environment for the healing of the wound. To achieve transparency upon contact with a liquid, the refractive index of the fibers used in the hydrophilic fiber layer is close to the refractive index of the target liquid. According to the technical solution of the present invention, the refractive index of the constituent material of the hydrophilic fiber layer is in the range of 1.3 to 1.7, and preferably in the range of 1.33 to 1.54.
The diameter of the hydrophilic fiber in the hydrophilic fiber layer is in the range of 30 to 500nm, preferably 30 to 300 nm. Further, the pores in the hydrophilic fiber layer have a diameter in the range of 0.06 to 1.0 μm, preferably 0.06 to 0.5 μm. In addition, the porosity in the hydrophilic fiber layer is in the range of 50 to 95%, preferably 70 to 90%, more preferably 85 to 90%.
Preferably, the grammage of the hydrophilic fiber layer is 1 to 20g/m2Preferably 1 to 10g/m2Within the range of (1).
The hydrophilic fiber used for constituting the medical nonwoven sheet may be appropriately selected from among fiber materials generally used in the field for manufacturing wound dressings, as long as the refractive index of the constituent material of the fiber is close to that of the target liquid. Preferably, the hydrophilic fibers are selected from one or more of the following: polyamide fibers, polyimide fibers, crosslinked polyvinyl alcohol fibers, crosslinked polyethylene oxide fibers, chitosan fibers, and polylactic acid fibers, as well as other electrospun biopolymer fibers.
Preferably, the polyamide fibers are nylon 6 fibers. The nylon 6 film manufactured by the general casting method has no microstructure in the inside thereof, and its inherent water contact angle is about 31 °. According to the wetting law, a material that increases the inherent hydrophilicity will further increase its hydrophilicity. Therefore, when a nylon 6 nonwoven fabric is manufactured by an electrospinning technique, the water contact angle of the nonwoven fabric is reduced to 0 °, which becomes a super-hydrophilic material. The superhydrophilic material allows water to automatically permeate into the pores of the nonwoven material, thereby replacing the gas phase in the pores of the nonwoven material with a liquid phase. Once this replacement is done, the optical properties of the nonwoven material will differ from those of its dry state, thereby changing to a transparent state. Therefore, preferably, the hydrophilic fiber layer is an electrospun hydrophilic fiber layer. More preferably, the hydrophilic fiber layer is an electrospun nylon 6 fiber layer or an electrospun crosslinked polyvinyl alcohol fiber layer.
The thickness of the hydrophilic fiber layer is in the range of 20 to 200. mu.m, preferably 20 to 100. mu.m, and further preferably 20 to 50 μm.
Fig. 1 shows a schematic view of a medical nonwoven sheet 1 according to an embodiment of the present invention.
Another aspect of the present invention provides a wound dressing, which comprises:
a release layer;
according to the medical non-woven fabric sheet, the medical non-woven fabric sheet is arranged on the release layer, and the edge of the medical non-woven fabric sheet is positioned in the edge of the release layer;
the transparent film layer is arranged above the medical non-woven fabric sheet and the release layer, and the edge of the transparent film layer exceeds the edge of the medical non-woven fabric sheet and is positioned in the edge of the release layer; and
the supporting layer covers at least one part of the transparent film layer and is attached to the release layer.
There is no limitation on the specific type of release layer that may be used in the present invention, which may be selected from suitable release papers, release films, etc. commonly used in dressing applications in the medical field. There is no particular limitation on the specific type of transparent film layer that may be used in the present invention, which may be appropriately selected in the art, and preferably, the transparent film layer is a Polyurethane (PU) film. There is no particular limitation on the specific type of support layer that may be used in the present invention, and materials having certain support properties in the art, such as paper, plastic films, and the like, may be used.
Fig. 2A shows a top view of a specific example of a wound dressing according to an embodiment of the present invention. Fig. 2B shows a schematic cross-sectional view of the wound dressing along line a in fig. 2A. As shown in fig. 2A and 2B, the wound dressing 2 includes, in order: a release layer 3; a medical non-woven fabric sheet 4, wherein the medical non-woven fabric sheet 4 is arranged on the release layer 3, and the edge of the medical non-woven fabric sheet 4 is positioned in the edge of the release layer 3; a transparent film layer 5, wherein the transparent film layer 5 is arranged above the medical non-woven fabric sheet 4 and the release layer 3, and the edge of the transparent film layer 5 exceeds the edge of the medical non-woven fabric sheet 4 and is positioned in the edge of the release layer 3; and a support layer 6, wherein the support layer 6 covers at least a part of the transparent film layer 5 and is attached to the release layer 3. Furthermore, the support layer 6 has through holes 7, thereby exposing the underlying transparent film layer 5.
In the above embodiments according to the present invention, the shapes of the release layer 3, the nonwoven fabric sheet 4 and the transparent film layer 5 are illustrated in an elliptical shape, but the present invention is not limited to this specific shape. The release layer 3, the nonwoven fabric sheet 4 and the transparent film layer 5 may also have another shape such as a circle, a rectangle, a square, etc., as required. The release layer 3, the nonwoven fabric sheet 4 and the transparent film layer 5 may even have an irregular shape, for example, with an extended end (protrusion) for facilitating tearing of the release layer. In the above embodiment according to the present invention, the supporting layer 6 is illustrated in a ring shape, and the supporting layer 6 covers the periphery of the transparent film layer 5, but the present invention is not limited to this specific shape and covering form, and the supporting layer 6 may also have other shapes or even irregular shapes according to specific needs, and may cover the whole surface of the transparent film layer 5.
In use of the wound dressing 2, the release layer 3 is first peeled off, the side of the wound dressing 2 where the nonwoven fabric sheet 4 is exposed is attached to the wound, and the support layer 6 is peeled off after the wound dressing 2 is fixed.
Fig. 3A shows a top view of another specific example of a wound dressing according to an embodiment of the present invention. Fig. 3B shows a schematic cross-sectional view of the wound dressing along line a in fig. 3A. The wound dressing shown in fig. 3A and 3B differs from the wound dressing shown in fig. 2A and 2B in that: the edge of the transparent film layer 5 is attached to the release layer 3 through the hydrocolloid layer 8, and the hydrocolloid layer 8 is positioned between the edge of the non-woven fabric sheet 4 and the edge of the release layer 3 in the direction parallel to the plane of the wound dressing 2.
Generally, during the use of wound dressings, the transparent film layer is prone to wrinkling caused by tension during prolonged contact rubbing with the skin, resulting in strong wound discomfort for the patient. The addition of the hydrocolloid layer 8 in the construction of the wound dressing 2 reduces the tension and makes the transparent film layer less prone to wrinkling, thereby improving comfort.
Fig. 4A shows a top view of yet another specific example of a wound dressing according to an embodiment of the present invention. Fig. 4B shows a schematic cross-sectional view of the wound dressing along line a in fig. 4A. The wound dressing shown in fig. 4A and 4B differs from the wound dressing shown in fig. 3A and 3B in that: the hydrocolloid layer 8 surrounds the nonwoven sheet 4 and is in contact with said nonwoven sheet 4.
The present invention will be described in more detail with reference to examples. It should be noted that the description and examples are intended to facilitate the understanding of the invention, and are not intended to limit the invention. The scope of the invention is to be determined by the claims appended hereto.
Examples
In the present invention, the materials used are all commercial products and are used without further purification treatment, unless otherwise indicated.
Test method for nonwoven sheet structure
In the following examples according to the present invention, the structural characteristics of the obtained nonwoven fabric sheet sample were characterized by examining parameters such as refractive index, fiber diameter, pore diameter, and porosity of the constituent materials of the sample. Specifically, the average diameter of the fibers was obtained by measuring the diameters of 100 fibers by a Scanning Electron Microscope (SEM) and calculating the average value thereof; the pore diameter was measured according to the specific method steps specified in the ASTM-E1294 standard. Further, the porosity of the sample was calculated according to the following formula:
porosity (P%) (1-m)nw/ρ·H·S)×100％
Wherein m isnwIs the mass (unit: g) of the target nonwoven fabric measured by a balance; ρ is the density of the material (unit: g/cm)3) (ii) a H is the thickness (unit: cm) of the nonwoven fabric; s is the area (unit: cm) of the nonwoven fabric2)。
Example 1
The polyvinyl alcohol non-woven fabric sheet is prepared by an electrostatic spinning process. Specifically, first, polyvinyl alcohol (available from clony) was dissolved in distilled water to prepare a polyvinyl alcohol solution having a concentration of 15% by weight. Then, the polyvinyl alcohol solution was spun into a polyvinyl alcohol fiber nonwoven fabric sheet 1 by using an electrostatic spinning machine of NS-LAB type produced by ELMARCO corporation. The refractive index of the polyvinyl alcohol fiber in the polyvinyl alcohol fiber non-woven fabric sheet 1 is 1.50 and the diameter is 120-180 nm. The polyvinyl alcohol fiber nonwoven fabric sheet 1 has pores with a diameter of 0.2 to 0.5 μm, a porosity of about 80%, and a basis weight of 3.5g/m2And a thickness of 80 μm.
Example 2
A polyvinyl alcohol fiber nonwoven fabric sheet 2 was prepared by an electrospinning process in a similar manner to example 1. The refractive index of the polyvinyl alcohol fiber in the polyvinyl alcohol fiber non-woven fabric sheet 2 is 1.50 and the diameter is 200-500 nm. The polyvinyl alcohol fiber nonwoven fabric sheet 2 has pores with a diameter of 0.4 to 1.0 μm, a porosity of about 70%, and a basis weight of 7 g/m2And a thickness of 160 μm.
Example 3
Preparing the nylon 6 non-woven fabric sheet by an electrostatic spinning process. Specifically, first, nylon 6 (available from BASF) was dissolved in an aqueous formic acid/acetic acid solution to prepare a nylon 6 solution having a concentration of 15 wt%. Then, the nylon 6 solution was spun into a nylon 6 nonwoven fabric sheet 1 by using an electrostatic spinning machine of NS-LAB type produced by ELMARCO corporation. The nylon 6 fibers in the nylon 6 nonwoven fabric sheet 1 had a refractive index of 1.53 and a diameter of 30 nm. The diameter of the pores in the nylon 6 nonwoven fabric sheet 1 was in the range of 0.06 to 0.1. mu.m, the porosity was about 90%, and the grammage was 1g/m2And has a thickness of 20 μm.
Example 4
A nylon 6 nonwoven fabric sheet 2 was prepared by an electrospinning process in a similar manner to example 3. The nylon 6 fibers in the nylon 6 nonwoven fabric sheet 2 had a refractive index of 1.53 and a diameter of 260 nm.The diameter of the pores in the nylon 6 nonwoven fabric sheet 2 was in the range of 0.2 to 0.5. mu.m, the porosity was about 85%, and the grammage was 3g/m2And has a thickness of 35 μm.
Water absorption transparency test
The nonwoven fabric sheets prepared in examples 1 to 4 above were taken, respectively, 3. mu.L of water was dropped onto the surfaces thereof and the surface states of the nonwoven fabric sheets were observed. The nonwoven fabric sheet samples prepared in examples 1 to 4 all absorbed water and became transparent within 3 seconds, indicating that they had good water absorption transparency.
Moisture Vapor Transmission Rate (MVTR) test
The nonwoven fabric sheets prepared in examples 1 to 4 above were each taken as a sample and tested for moisture vapor permeability (MVTR) according to the method specified in the national standard GB/T1037-1988.
The results showed that the polyvinyl alcohol fiber nonwoven fabric sheet 1 had a moisture vapor permeability (MVTR) of 6258.5775g/m224 h; the moisture vapor permeability (MVTR) of the polyvinyl alcohol fiber non-woven fabric sheet 2 is 8404.573g/m224 h; the moisture vapor permeability (MVTR) of the nylon 6 non-woven fabric sheet 1 is 9240.9855g/m224 h; and the nylon 6 nonwoven fabric sheet 2 has a moisture vapor permeability (MVTR) of 9416.5235g/m2And/24 h. The result proves according to the utility model discloses a non-woven fabrics sheet that technical scheme prepared has very high wet steam air permeability. The higher the moisture vapor permeability, the drier and more comfortable the skin surface of the patient, which can improve the comfort of the patient.
Bacteria resistance test
The nonwoven fabric sheets prepared in examples 1 to 4 above were each tested for their antibacterial properties as a sample. Specifically, a container was provided in which an agar plate with bacteria (bacillus subtilis) was disposed on the top layer, a nonwoven fabric sheet sample was disposed on the middle layer, a RODAC panel (produced by hopebio corporation) was disposed on the lower layer, and no other spacer was disposed between the top layer and the lower layer except for the nonwoven fabric sheet sample. Then 100g of pressure was applied to the top. After 24 hours of maintenance, there was no bacterial expression on the RODAC panel. This result can prove according to the utility model discloses a non-woven fabrics sheet that technical scheme prepared has very excellent fungus performance that hinders.
Water absorption rate
The nonwoven fabric sheets prepared in examples 1 to 4 above were each used as a sample to test the water absorption rate thereof at 3 seconds.
Specifically, the initial weight M of the sample is weighed0Then, after immersing it in a balanced salt solution (produced by Fisher Scientific) for 3 seconds, the weight M thereof was measuredtThe water absorption was then calculated by the following formula:
water absorption rate ═ Mt-M0)/M0×100％
The results showed that the water absorption of the polyvinyl alcohol fiber nonwoven fabric sheet 1 was 1943.6%; the water absorption rate of the polyvinyl alcohol fiber non-woven fabric sheet 2 is 1577.7%; the water absorption rate of the nylon 6 non-woven fabric sheet 1 is 1905.3%; and the water absorption rate of the nylon 6 nonwoven fabric sheet 2 was 2540.5%. The result proves according to the utility model discloses a non-woven fabrics sheet that technical scheme prepared has very excellent water absorption performance, can satisfy among the medical field to the requirement of wound dressing rapid absorption wound exudate.
It will be apparent to those skilled in the art that various changes and modifications can be made in the present disclosure without departing from the spirit and scope of the disclosure. Thus, if such modifications and variations of the present disclosure fall within the scope of the claims of the present invention and their equivalents, the present disclosure is also intended to encompass such modifications and variations.
Claims (10)
1. A medical nonwoven fabric sheet characterized by comprising a hydrophilic fiber layer, the refractive index of a constituent material of hydrophilic fibers in the hydrophilic fiber layer being in the range of 1.3-1.7 and the diameter of the hydrophilic fibers being in the range of 30 to 500nm, the diameter of pores in the hydrophilic fiber layer being in the range of 0.06 to 1.0 μm and the porosity being in the range of 50-95%.
2. The medical nonwoven fabric sheet according to claim 1, wherein the grammage of the hydrophilic fiber layer is 1 to 20g/m2Within the range of (1).
3. The medical nonwoven fabric sheet according to claim 1, wherein the hydrophilic fiber is selected from one of the following: polyamide fibers, polyimide fibers, crosslinked polyvinyl alcohol fibers, crosslinked polyethylene oxide fibers, chitosan fibers, and polylactic acid fibers.
4. The medical nonwoven fabric sheet according to claim 3, wherein the polyamide fiber is a nylon 6 fiber.
5. The medical nonwoven fabric sheet according to claim 1, wherein the hydrophilic fiber layer is an electrospun hydrophilic fiber layer.
6. The medical nonwoven fabric sheet according to claim 1, wherein the thickness of the hydrophilic fiber layer is in the range of 20 to 200 μm.
7. A wound dressing, comprising in order:
a release layer;
the medical nonwoven fabric sheet according to any one of the preceding claims 1 to 6, which is disposed on the release layer with an edge of the medical nonwoven fabric sheet located within an edge of the release layer;
the transparent film layer is arranged above the medical non-woven fabric sheet and the release layer, and the edge of the transparent film layer exceeds the edge of the medical non-woven fabric sheet and is positioned in the edge of the release layer; and
the supporting layer covers at least one part of the transparent film layer and is attached to the release layer.
8. The wound dressing of claim 7, wherein the support layer has through holes exposing the underlying transparent film layer.
9. A wound dressing according to claim 7, wherein the edges of the transparent film layer are attached to the release layer by a hydrocolloid layer located between the edges of the non-woven sheet material and the edges of the release layer in a direction parallel to the plane of the wound dressing.
10. The wound dressing of claim 9, wherein the hydrocolloid layer is in contact with the nonwoven sheet.
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| CN202020959419.0U CN214318296U (en) | 2020-05-29 | 2020-05-29 | Medical nonwoven sheet and wound dressing |
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| CN202020959419.0U CN214318296U (en) | 2020-05-29 | 2020-05-29 | Medical nonwoven sheet and wound dressing |
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