CN106362191A - Medical dressing with drug loading function and preparation method thereof - Google Patents
Medical dressing with drug loading function and preparation method thereof Download PDFInfo
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- CN106362191A CN106362191A CN201610841866.4A CN201610841866A CN106362191A CN 106362191 A CN106362191 A CN 106362191A CN 201610841866 A CN201610841866 A CN 201610841866A CN 106362191 A CN106362191 A CN 106362191A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0015—Electro-spinning characterised by the initial state of the material
- D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
- D01D5/0092—Electro-spinning characterised by the electro-spinning apparatus characterised by the electrical field, e.g. combined with a magnetic fields, using biased or alternating fields
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
- D01F1/10—Other agents for modifying properties
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
- D01F6/44—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from mixtures of polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds as major constituent with other polymers or low-molecular-weight compounds
- D01F6/50—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from mixtures of polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds as major constituent with other polymers or low-molecular-weight compounds of polyalcohols, polyacetals or polyketals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Textile Engineering (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mechanical Engineering (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a preparation method of a medical dressing with a drug loading function. The method includes the following steps that firstly, an electrospinning solution containing drug is prepared; secondly, electrostatic spinning is conducted; thirdly, a prepared product is subjected to drug controlled release testing. The prepared composite medical dressing containing antibacterial drug/PVA/oxidized graphene is excellent in processing performance. The prepared product has excellent drug controlled release capacity. The method is simple in process, low in cost and easy to use and popularize widely in the medical material field.
Description
Technical field
The present invention relates to medical material field is and in particular to a kind of have the medical dressing carrying medicine function and its preparation side
Method.
Background technology
Traditional method controlled treatment trauma, burn is coating antibacterials on wound, is then wrapped up with gauze, so may be used
To absorb wound exudate, prevent bacterium infection, reduce cicatrization, preventing secondary damages, but medicine is also brought with Wound contact
Some problems, such as too high drug level brings certain impact to the histoorgan of human normal, too low drug level
Do not have the effect for the treatment of and prevention.Normal gauze, because being easily contaminated, needs often to change, this undoubtedly exacerbates patient's
Painful.
And the appearance with the degradable medical dressing carrying medicine function solves these problems.Using having biological degradability
The wound dressing of non woven cloth in polymer manufacture both solved the problems, such as that traditional dressing needed often to change, medicine can be made more preferable again
Release.
As medical dressing, the macromolecular material with good biocompatibility has the advantage of uniqueness.Wherein, polyethylene
Alcohol (pva) has more excellent degradability, biocompatibility and chemical stability.Its application in life is quite varied,
A lot of purposes are had in textile industry, chemical industry, paper industry, daily use chemicals industry and agricultural.
Pva can by being coated with, the method such as electrostatic spinning prepares macromolecule membrane and is used as medical dressing.Wherein, Static Spinning
Silk (electrospinning) be a kind of spin in the presence of electrostatic force fiber method.The diameter of electrospinning fibre is generally between hundreds of nanometer extremely
Between several microns, collected with non-woven fabrics form, form unilateral array or by stacking composition multiple structure.So, there is electrospinning system
Standby thin film has good permeability, meets the requirement of medical dressing.
Graphene family, as a kind of new material of monoatomic layer, has extraordinary mechanics, calorifics, electricity and magnetics
Can, also obtained great concern in recent years, can be added to, as reinforcing agent, the mechanicalness improving composite in polymer.
Additionally, the lamellar structure of Graphene can adsorb medicine, play the effect of medicament slow release.
Cn103938366a discloses a kind of method that electrostatic spinning prepares graphene oxide and composite membrane of polyvinyl alcohol.But
It is not directed to medical.
Water miscible graphene oxide is added pva solution by the present invention, adds certain density in the solution through experiment
Antiseptic solution, is obtained the nanofiber dressing with medicine controlled releasing performance, and the addition of medicine is not had an impact electricity by electrospinning
The performance spun.
Content of the invention
It is an object of the invention to provide a kind of preparation method with the medical dressing carrying medicine function.This preparation method letter
Just, excellent medicament slow release is had by the dressing that medicine loading obtains and put performance.
To achieve the object of the present invention, technical scheme comprises the following steps:
Step 1: the preparation of electrospun solution
Pva is dissolved in distilled water under the conditions of 70-80 DEG C, prepared pva solution, concentration 5-15w/v%；After cooling, mix
Enter the graphene oxide water solution that concentration is 0.1-5mg/ml；Pva solution and graphene oxide solution volume ratio are 20:1-1:1；
Then add the water-soluble antibacterial thing aqueous solution that appropriate concentration is 0.1-5mg/ml；Pva solution and the volume ratio of drug solution
For 100:1-5:1；Resulting solution is electrospun solution；
Step 2: electrostatic spinning
The process conditions of electrostatic spinning are set to: by high voltage power supply output voltage be 10-25kv, solidification distance, accept
The distance between device and shower nozzle are 10-25cm, and the electrospinning time is 10min-3h；
Step 3: medicine controlled releasing test
Medicine controlled releasing test is carried out to prepared load medicine medical dressing.
The Reaction conditions range that the present invention is implemented and each reaction condition of optimization are specific as follows:
Step 1: the configuration of electrospun solution
Pva is dissolved in distilled water under the conditions of 70-80 DEG C, preferred 5-15w/v% (further 8-13%, optimum are obtained
10-13%), after cooling, be mixed into graphene oxide water solution (be stabilizer with blocked polyethers f-127, see patent:
201310130242.8) (concentration 0.1-5mg/ml of preferred graphene oxide, further 0.5-3mg/ml, optimum 1-3mg/
ml).Pva solution and graphene oxide solution volume ratio (preferably 20:1-1:1, further 15:1-5:1mg/ml, optimum 10:1),
Then add appropriate water solublity antibacterials aqueous solution (preferably norfloxacin, oxygen norfloxacin；Preferably concentration 0.1-5mg/
Ml, further 0.5-3mg/ml, optimum 3mg/ml), the volume ratio of pva solution and drug solution, preferably 100:1-5:1, enters one
Step 50:1-10:1, optimum 20:1, resulting solution is electrospun solution
Step 2: electrostatic spinning process
The process conditions of electrostatic spinning are as follows:
High voltage power supply output voltage is adjusted to 10-25kv, further 15-20kv, optimum 15kv, solidification distance (accepts
The distance between device and shower nozzle) it is adjusted to 10-25cm, further for 10-20cm, optimum is 15cm.The preferably electrospinning time
For 10min-3h, further for 30min-2h, optimum 30min-1h.
Step 3: medicine controlled releasing aptitude tests are carried out to prepared medical dressing.
Beneficial effect acquired by the present invention:
(1) preparation method of the present invention is easy to implement, application cost low it is easy to industrial applications.
(2) the product medicament load capacity height prepared by the method for the present invention, medicine controlled releasing ability are excellent.
Brief description
Fig. 1 is the flow chart of electrospinning processes used herein.
Fig. 2 is the finished product figure of embodiment 1.
Fig. 3 is the microcosmic electromicroscopic photograph of embodiment 1.
Fig. 4 by with ultraviolet-uisible spectrophotometer to respectively to the comparative example 1 being taken, comparative example 2, comparative example 3 and real
The different solutions applying example 1 are tested, the comparison diagram of testing drug useful load.
Fig. 5 is the drug release patterns figure of comparative example 3.
Fig. 6 is the drug release patterns figure of enforcement 1.
Specific embodiment
The present invention will be further described with reference to embodiments, but following embodiment has no to protection scope of the present invention
Clearly limit.
Embodiment 1
Pva is dissolved in distilled water under the conditions of 70-80 DEG C, prepared 13w/v solution, after cooling, it is mixed into 3mg/ml oxygen
Graphite aqueous solution.Pva solution and graphene oxide solution volume ratio 10:1, then add 3mg/ml norfloxacin water-soluble
Liquid, pva solution is 20:1 with the volume ratio of drug solution.Resulting solution is electrospun solution.
High voltage power supply output voltage is adjusted to 15kv, solidification distance the distance between (receiving device with shower nozzle) is adjusted to
15cm, the electrospinning time is 30min.
Embodiment 2
Pva is dissolved in distilled water under the conditions of 70-80 DEG C, prepared 10w/v solution, after cooling, it is mixed into 2mg/ml oxygen
Graphite aqueous solution.Pva solution and graphene oxide solution volume ratio 10:1, then add 3mg/ml norfloxacin water-soluble
Liquid, pva solution is 10:1 with the volume ratio of drug solution.Resulting solution is electrospun solution.
High voltage power supply output voltage is adjusted to 15kv, solidification distance the distance between (receiving device with shower nozzle) is adjusted to
15cm, the electrospinning time is 30min.
Embodiment 3
Pva is dissolved in distilled water under the conditions of 70-80 DEG C, prepared 13w/v solution, after cooling, it is mixed into 3mg/ml oxygen
Graphite aqueous solution.Pva solution and graphene oxide solution volume ratio 10:1, then add 3mg/ml norfloxacin water-soluble
Liquid, pva solution is 20:1 with the volume ratio of drug solution.Resulting solution is electrospun solution.
High voltage power supply output voltage is adjusted to 10kv, solidification distance the distance between (receiving device with shower nozzle) is adjusted to
10cm, the electrospinning time is 30min.
Embodiment 4
Pva is dissolved in distilled water under the conditions of 70-80 DEG C, prepared 13w/v solution, after cooling, it is mixed into 1mg/ml oxygen
Graphite aqueous solution.Pva solution and graphene oxide solution volume ratio 10:1, then add 1mg/ml norfloxacin water-soluble
Liquid, pva solution is 10:1 with the volume ratio of drug solution.Resulting solution is electrospun solution.
High voltage power supply output voltage is adjusted to 15kv, solidification distance the distance between (receiving device with shower nozzle) is adjusted to
15cm, the electrospinning time is 30min.
Embodiment 5
Pva is dissolved in distilled water under the conditions of 70-80 DEG C, prepared 13w/v solution, after cooling, it is mixed into 3mg/ml oxygen
Graphite aqueous solution.Pva solution and graphene oxide solution volume ratio 10:1, then add 3mg/ml norfloxacin water-soluble
Liquid, pva solution is 20:1 with the volume ratio of drug solution.Resulting solution is electrospun solution.
High voltage power supply output voltage is adjusted to 15kv, solidification distance the distance between (receiving device with shower nozzle) is adjusted to
15cm, the electrospinning time is 1h.
Comparative example 1
Pva is dissolved in distilled water under the conditions of 70-80 DEG C, prepared 13w/v solution, resulting solution is electrospun solution.
High voltage power supply output voltage is adjusted to 15kv, solidification distance the distance between (receiving device with shower nozzle) is adjusted to
15cm, the electrospinning time is 30min.
Comparative example 2
Pva is dissolved in distilled water under the conditions of 70-80 DEG C, prepared 13w/v solution, after cooling, it is mixed into 3mg/ml oxygen
Graphite aqueous solution.Pva solution and graphene oxide solution volume ratio 10:1.Resulting solution is electrospun solution.
High voltage power supply output voltage is adjusted to 15kv, solidification distance the distance between (receiving device with shower nozzle) is adjusted to
15cm, the electrospinning time is 30min.
Comparative example 3
Pva is dissolved in distilled water under the conditions of 70-80 DEG C, prepared 13w/v solution, after cooling, then adds 3mg/
Ml norfloxacin aqueous solution, pva solution is 20:1 with the volume ratio of drug solution.Resulting solution is electrospun solution.
High voltage power supply output voltage is adjusted to 15kv, solidification distance the distance between (receiving device with shower nozzle) is adjusted to
15cm, the electrospinning time is 30min.
Related embodiment and comparative example are carried out with test and the detection of correlation.
Can be seen that and successfully made by the preparation method of the present invention from the photo in kind of embodiment 1 and microcosmic electromicroscopic photograph
The standby medical dressing containing antibacterials.
An equal amount of pure pva thin film (comparative example 1), graphene oxide-pva thin film (comparative example 2), pva is taken to be combined and carry
Medicine thin film (comparative example 3), the composite drug-loaded thin film of graphene oxide-pva (embodiment 1) be respectively put into equipped with 4ml distilled water from
In heart pipe.After infiltration 1h, take 2ml solution, with ultraviolet-uisible spectrophotometer to surveying to the different solutions being taken respectively
Examination, compares acquired results and finds, for the characteristic absorption of norfloxacin at 275nm, absorbance is bigger, illustrates that the concentration of medicine is got over
Height is that is to say, that embodiment 1 has higher drug load.
Contrast the composite drug-loaded thin film of pva (comparative example 3) aqueous solution in release amount of medicine percentage ratio over time with oxygen
Graphite alkene-pva (embodiment 1) composite drug-loaded film water drug in solution burst size percentage ratio over time, Ke Yifa
Now excellent medicine controlled releasing performance is had by product prepared by the method for the present invention.
The protection domain of the claims in the present invention is not limited to the content of embodiment, any preparation side according to thinking of the present invention
Method and products obtained therefrom are all the contents that the present invention protects.
Claims (6)
1. a kind of preparation method with the medical dressing carrying medicine function, rises and is characterised by, comprise the steps:
Step 1: the preparation of electrospun solution
Pva is dissolved in distilled water under the conditions of 70-80 DEG C, prepared pva solution, concentration 5-15w/v%；After cooling, it is mixed into dense
Spend the graphene oxide water solution for 0.1-5mg/ml；Pva solution and graphene oxide solution volume ratio are 20:1-1:1；Then
Add the water-soluble antibacterial thing aqueous solution that appropriate concentration is 0.1-5mg/ml；Pva solution with the volume ratio of drug solution is
100:1-5:1；Resulting solution is electrospun solution；
Step 2: electrostatic spinning
The process conditions of electrostatic spinning are set to: high voltage power supply output voltage is 10-25kv, solidification distance, i.e. receiving device
It is 10-25cm with the distance between shower nozzle, the electrospinning time is 10min-3h；
Step 3: medicine controlled releasing test
Medicine controlled releasing test is carried out to prepared load medicine medical dressing.
2. a kind of preparation method with the medical dressing carrying medicine function according to claim 1, rises and is characterised by:
In described step 1, pva solution concentration is 8-13w/v%；The graphene oxide water solution concentration being mixed into is 0.5-3mg/
ml；Pva solution and graphene oxide solution volume ratio are 15:1-5:1；Water-soluble antibacterial thing concentration of aqueous solution is 0.5-3mg/
ml；Pva solution is 50:1-10:1 with the volume ratio of drug solution.
3. a kind of preparation method with the medical dressing carrying medicine function according to claim 2, rises and is characterised by:
In described step 1, pva solution concentration is 10-13w/v%；The graphene oxide water solution concentration being mixed into is 1-3mg/ml；
Pva solution and graphene oxide solution volume ratio are 10:1；Water-soluble antibacterial thing concentration of aqueous solution is 03mg/ml；Pva solution
Volume ratio with drug solution is 20:1.
4. a kind of preparation method with the medical dressing carrying medicine function according to any one of claim 1-3, its feature
It is:
Water-soluble antibacterial thing aqueous solution is norfloxacin, oxygen norfloxacin.
5. a kind of according to prepared by the method for claim 1-4 have carry medicine function medical dressing.
6. a kind of application in antimicrobial drug Material Field for the dressing with load medicine function according to claim 5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610841866.4A CN106362191A (en) | 2016-09-22 | 2016-09-22 | Medical dressing with drug loading function and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610841866.4A CN106362191A (en) | 2016-09-22 | 2016-09-22 | Medical dressing with drug loading function and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107158444A (en) * | 2017-05-05 | 2017-09-15 | 苏州大学 | A kind of antibacterial hyperplasia composite membrane and preparation method thereof |
| CN109453421A (en) * | 2018-11-19 | 2019-03-12 | 无锡中科光远生物材料有限公司 | For promoting the preparation method of the nano fiber scaffold of wound healing |
| CN110152049A (en) * | 2019-06-10 | 2019-08-23 | 东北林业大学 | A kind of preparation method for the chitosan-based medicament-carrying nano-fiber membrane can be applied to medical wound dressing |
| CN111058145A (en) * | 2020-01-10 | 2020-04-24 | 中原工学院 | Graphene drug-loaded antibacterial composite fabric and preparation method thereof |
| CN111888516A (en) * | 2020-08-11 | 2020-11-06 | 王宏澜 | Antibacterial medical coated non-woven fabric and preparation method thereof |
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| CN103394119A (en) * | 2013-07-10 | 2013-11-20 | 中国人民解放军第四军医大学 | Method for preparing nanometer bionic slow release biomedical dressing by electrostatic spinning |
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| CN104761737A (en) * | 2015-04-15 | 2015-07-08 | 武汉理工大学 | Method for preparing collagen/graphene oxide nano fiber composite film by electrostatic spinning |
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| CN111888516A (en) * | 2020-08-11 | 2020-11-06 | 王宏澜 | Antibacterial medical coated non-woven fabric and preparation method thereof |
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