CN113604958A - Preparation method and application of anti-infection composite layer medical dressing - Google Patents
Preparation method and application of anti-infection composite layer medical dressing Download PDFInfo
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- CN113604958A CN113604958A CN202110917658.9A CN202110917658A CN113604958A CN 113604958 A CN113604958 A CN 113604958A CN 202110917658 A CN202110917658 A CN 202110917658A CN 113604958 A CN113604958 A CN 113604958A
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- silk fibroin
- layer
- infection
- medical dressing
- chitosan
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- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 5
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- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
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Abstract
The invention belongs to the field of new materials, and particularly relates to a preparation method of an anti-infection composite layer medical auxiliary material and a composite layer medical dressing which takes silk fibroin and chitosan/polyethylene oxide as raw materials, and is prepared by electrostatic spinning and cross-linking modification. The invention solves the defects of the existing dressing, and the double-layer nanofiber membrane formed by taking chitosan fiber as an inner layer and silk fibroin fiber membrane as an outer layer has good antibacterial property, softness, water absorption and bioactivity.
Description
Technical Field
The invention belongs to the field of new materials, and particularly relates to a preparation method and application of an anti-infection composite layer pharmaceutical adjuvant.
Background
The skin is the largest organ of a human body and is a physical barrier with the external environment, in recent years, the skin is frequently damaged due to wounds, abrasions, burns, surgical incisions, diabetic ulcers and other reasons, the immunity of the damaged skin is reduced, the damaged skin is easily infected by germs, and the skin can not self-heal or even threaten the life under the condition of severe damage. At this time, the medical dressing is needed to protect the wound, so that the wound can be prevented from being infected by dehydration and the external environment, a moist environment is provided for the skin repair process, the growth of new tissues is accelerated, and the wound healing is promoted. Traditional medical dressing that uses cotton gauze and cotton pad as representative, though there is certain liquid absorptivity, simultaneously can also keep apart skin and external world and then protect skin, but easily glue impaired tissue at the wound healing in-process, lead to the dressing induration, it is not good with the skin laminating, and cause the damage to impaired skin once more easily when changing the dressing, be unfavorable for the healing of wound, consequently, it is good to need to develop the moisture absorption gas permeability, can prevent that body fluid from oozing and bacterial infection, the non-adhesion wound, convenient to use's novel functional medical dressing.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a preparation method of an anti-infection composite layer medical dressing, which overcomes the defects of the existing dressing, and the double-layer nanofiber membrane formed by taking chitosan fiber as an inner layer and silk fibroin fiber membrane as an outer layer has good antibacterial property, softness, water absorption and bioactivity.
In order to achieve the technical purpose, the technical scheme of the invention is as follows:
a preparation method of an anti-infection composite layer medical dressing is prepared by taking silk fibroin and chitosan/polyethylene oxide as raw materials and adopting an electrostatic spinning technology.
The preparation method comprises the following specific steps:
step 1, preparation of spinning solution: dissolving silk fibroin in acid to prepare a silk fibroin solution; dissolving chitosan and polyoxyethylene in acid to prepare a chitosan/polyoxyethylene spinning solution;
step 2, electrospinning a double-layer nanofiber membrane: performing electrostatic spinning on the silk fibroin solution to obtain a silk fibroin layer, drying, and performing electrostatic spinning on the chitosan/polyethylene oxide layer on the silk fibroin layer to obtain a double-layer nanofiber membrane;
step 3, crosslinking treatment: and performing EDC-NHS crosslinking treatment on the double-layer nanofiber membrane to obtain the infection-preventing composite layer medical dressing.
The average diameter of the chitosan/polyethylene oxide layer in the double-layer nanofiber membrane was 97.97 nm.
The average diameter of the silk fibroin layer in the double-layer nanofiber membrane is 94.14 nm.
In the step 1, the preparation method of the silk fibroin solution comprises the following steps: adding silk fibroin into formic acid to prepare a silk fibroin solution, wherein the concentration of the silk fibroin solution is 10 wt%; the preparation method of the chitosan/polyethylene oxide spinning solution comprises the following steps: dissolving chitosan and polyethylene oxide in 70% glacial acetic acid in a mass ratio of 7:3 to prepare a chitosan/polyethylene oxide spinning solution, wherein the concentration of the chitosan/polyethylene oxide spinning solution is 4 wt%.
In the step 2, the electrostatic spinning conditions are as follows: the voltage is 15-20kV, the distance between the spinneret tip and the receiver is 10-15cm, the flow rate of the injection pump is 0.5-1mL/h, the electrostatic spinning is carried out for 6-10h, the fiber filaments are peeled off from the aluminum foil, and the aluminum foil is placed in a drying oven for drying and storage.
In the step 3, the preparation method of the crosslinking treatment is disclosed: and soaking the double-layer nanofiber membrane into an EDC-NHS mixed solution, crosslinking for 1-2h, then cleaning with deionized water, and drying to obtain the infection-preventing composite layer medical dressing.
An anti-infection composite layer medical dressing is prepared by the method.
The medical auxiliary material is used in the field of tissue engineering.
The silk fibroin used on the outer layer of the double-layer nanofiber membrane of the anti-infection composite layer medical dressing is fibrin which is mainly generated by silkworms and spiders and has unique characteristic mechanical property and adjustable biodegradation rate; the chitosan in contact with a human body is a natural polysaccharide, has excellent histocompatibility, biodegradability, non-sensitization, no cytotoxicity and unique cationic antibacterial performance, and is used as the inner layer of the anti-infection composite layer medical dressing, so that the dressing has excellent antibacterial and anti-infection performance, better dilution rate and moisture retention rate, and simultaneously has softness and better fit with the skin of the human body.
From the above description, it can be seen that the present invention has the following advantages:
1. the invention solves the defects of the existing dressing, and the double-layer nanofiber membrane formed by taking chitosan fiber as an inner layer and silk fibroin fiber membrane as an outer layer has good antibacterial property, softness, water absorption and bioactivity.
2. The silk fibroin/polyethylene oxide composite material is prepared from silk fibroin and chitosan/polyethylene oxide serving as raw materials by an electrostatic spinning technology, and is simple and easy to operate, and process parameters are easy to control.
3. The chitosan is used as the inner layer of the dressing, can be directly contacted with the skin of a human body, has better antibacterial and anti-infection effects and better moisture absorption rate and moisture retention rate, can keep the wound surface moist when being contacted with the wound surface, and avoids the mechanical damage caused again when the dressing is replaced; biodegradable polyethylene oxide is added into the chitosan, so that the film forming property of chitosan electrostatic spinning is improved.
4. The silk fibroin fiber film is used as the dressing outer layer, and the excellent mechanical property of the fibrin is utilized, so that the healing of the wound surface can be accelerated better and faster.
5. The composite layer medical dressing prepared by the invention has better flexibility, has better touch feeling when being contacted with a human body, and can be widely applied to the field of tissue engineering.
Drawings
Fig. 1 is a picture of a double-layered nanofiber membrane prepared in example 3.
FIG. 2 is an electron microscope image of the infection-preventing composite layer medical dressing prepared in example 3.
FIG. 3 is an electron micrograph of the infection-preventing composite layer medical dressing prepared in example 3 soaked in SBF for 7 days.
Detailed Description
An embodiment of the present invention is described in detail with reference to fig. 1, fig. 2 and fig. 3, but the present invention is not limited in any way by the claims.
A preparation method of an anti-infection composite layer medical dressing comprises the following specific steps:
step 1, preparation of spinning solution: dissolving silk fibroin in formic acid, wherein the concentration of the prepared silk fibroin solution is 10 wt%; dissolving chitosan and polyoxyethylene (7:3) in 70% glacial acetic acid to prepare 4 wt% of spinning solution;
step 2, electrospinning a double-layer nanofiber membrane: firstly, performing electrostatic spinning on a silk fibroin layer, drying, and then directly performing electrostatic spinning on a chitosan/polyethylene oxide layer on the silk fibroin layer to obtain a double-layer nanofiber membrane; the spinning conditions of the electrostatic spinning technology are as follows: the spinning conditions in the electrostatic spinning technology are as follows: the voltage is 15-20kV, the distance between the spinneret tip and the receiver is 15-20cm, the flow rate of the injection pump is 0.5-1mL/h, continuous spinning is carried out for 6-10h, the spinning is peeled off from the aluminum foil, and the aluminum foil is placed in a drying oven for drying and storage;
step 3, crosslinking treatment: and (3) soaking the double-layer nanofiber membrane prepared in the step (2) in an EDC-NHS mixed solution, crosslinking for 2 hours, washing with deionized water, and drying to obtain the anti-infection composite layer medical dressing.
Example 1
Preparing a silk fibroin fiber membrane: mixing 1g of silk fibroin and 9g of formic acid, halving for 12h at room temperature to obtain a silk fibroin solution with the concentration of 10 wt%, serving as a mixed system A, preparing a consoling membrane by utilizing an electrostatic spinning technology, continuously spinning for 8h under the conditions that the relative humidity is 40% +/-5%, the temperature is 25 +/-5 ℃, the voltage is 20kV, the distance from the spinneret tip to a receiver is 20cm, the flow rate of an injection pump is 1mL/h, peeling off the silk fibroin from an aluminum foil, and drying in a drying box to obtain a silk fibroin nanofiber layer.
Example 2
Preparation of chitosan/polyethylene oxide nanofiber layer: dissolving 0.28g of chitosan in 70 wt% of glacial acetic acid solution, adding 0.12g of polyethylene oxide, stirring for 12 hours at room temperature to form a uniform mixed solution, namely a mixed system B, preparing a composite membrane by using an electrostatic spinning technology, continuously spinning for 8 hours under the conditions that the relative humidity is 40% +/-5%, the temperature is 25 +/-5 ℃, the voltage is 20kV, the distance between the spinneret tip and a receiver is 20cm, the flow rate of an injection pump is 1mL/h, peeling off the composite membrane from an aluminum foil, and drying in a drying box to obtain the chitosan/polyethylene oxide nanofiber layer.
Example 3
The preparation method of the anti-infection composite layer medical dressing comprises the following steps:
step 1, preparing a silk fibroin fiber membrane: mixing 1g of silk fibroin and 9g of formic acid, halving for 12 hours at room temperature to obtain a silk fibroin solution with the concentration of 10 wt%, serving as a mixed system A, preparing a consoling membrane by utilizing an electrostatic spinning technology, continuously spinning for 8 hours under the conditions that the relative humidity is 40% +/-5%, the temperature is 25 +/-5 ℃, the voltage is 20kV, the distance from the spinneret tip to a receiver is 20cm, the flow rate of an injection pump is 1mL/h, peeling off the consoling membrane from an aluminum foil, and placing the consoling membrane in a drying box for drying to obtain a silk fibroin nanofiber layer;
step 2, electrospinning a double-layer nanofiber membrane: dissolving 0.28g of chitosan in 70 wt% glacial acetic acid solution, adding 0.12g of polyethylene oxide, and stirring at room temperature for 12h to form a uniform mixed solution, namely a mixed system B; then directly carrying out electrostatic spinning on the mixed system B on the silk fibroin nanofiber layer which is just prepared, wherein the relative humidity is 40% +/-5%, the temperature is 25 +/-5 ℃, the voltage is 20kV, the distance between the spinneret tip and a receiver is 20cm, the flow rate of an injection pump is 1mL/h, continuously spinning for 8h, peeling off the silk fibroin nanofiber layer from an aluminum foil, and placing the silk fibroin nanofiber layer in a drying box for drying to obtain a double-layer nanofiber membrane;
step 3, crosslinking treatment: soaking in EDC-NHS mixed solution, washing with deionized water when crosslinking is carried out for 2 hours, and drying to obtain the infection-preventing composite layer medical dressing. The actual product of the medical dressing of this example is shown in fig. 1, and its electron micrograph is shown in fig. 2.
Performance detection
The nanofiber layers prepared in examples 1-3 were tested for breaking strength, hydrophilicity, water absorption and antibacterial properties and the results are given in the following table:
| sample (I) | Breaking strength/MPa | Water contact angle/° c | Water absorption/%) | Inhibition rate/%) |
| Example 1 | 6.1±0.1 | 116.3 | 380 | 0 |
| Example 2 | 2.7±0.2 | 51.52 | 1177 | 72.83 |
| Example 3 | 4.4±0.2 | / | 556 | 99.00 |
Fig. 3 is a scanning electron microscope image of a double-layer nanofiber membrane soaked in SBF for 7D, a crystal substance similar to a flower is grown on the smooth fiber surface, and it can be seen that in SBF, the double-layer nanofiber membrane has the capability of depositing hydroxyapatite, indicating that the double-layer nanofiber membrane has better bioactivity.
The tests show that the anti-infection antibacterial composite layer medical dressing has good mechanical strength, hydrophilic property and water absorption property, is wide in application range, and has high antibacterial property and biocompatibility.
It should be understood that the detailed description of the invention is merely illustrative of the invention and is not intended to limit the invention to the specific embodiments described. It will be appreciated by those skilled in the art that the present invention may be modified or substituted equally as well to achieve the same technical result; as long as the use requirements are met, the method is within the protection scope of the invention.
Claims (9)
1. A preparation method of an anti-infection composite layer medical dressing is characterized by comprising the following steps: the silk fibroin/polyethylene oxide composite material is prepared by taking silk fibroin and chitosan/polyethylene oxide as raw materials through an electrostatic spinning technology.
2. The method for preparing the infection-preventing composite layer medical dressing according to claim 1, wherein: the preparation method comprises the following specific steps:
step 1, preparation of spinning solution: dissolving silk fibroin in acid to prepare a silk fibroin solution; dissolving chitosan and polyoxyethylene in acid to prepare a chitosan/polyoxyethylene spinning solution;
step 2, electrospinning a double-layer nanofiber membrane: performing electrostatic spinning on the silk fibroin solution to obtain a silk fibroin layer, drying, and performing electrostatic spinning on the chitosan/polyethylene oxide layer on the silk fibroin layer to obtain a double-layer nanofiber membrane;
step 3, crosslinking treatment: and performing EDC-NHS crosslinking treatment on the double-layer nanofiber membrane to obtain the infection-preventing composite layer medical dressing.
3. The method for preparing the infection-preventing composite layer medical dressing according to claim 2, wherein: the average diameter of the chitosan/polyethylene oxide layer in the double-layer nanofiber membrane was 97.97 nm.
4. The method for preparing the infection-preventing composite layer medical dressing according to claim 2, wherein: the average diameter of the silk fibroin layer in the double-layer nanofiber membrane is 94.14 nm.
5. The method for preparing the infection-preventing composite layer medical dressing according to claim 2, wherein: in the step 1, the preparation method of the silk fibroin solution comprises the following steps: adding silk fibroin into formic acid to prepare a silk fibroin solution, wherein the concentration of the silk fibroin solution is 10 wt%; the preparation method of the chitosan/polyethylene oxide spinning solution comprises the following steps: dissolving chitosan and polyethylene oxide in 70% glacial acetic acid in a mass ratio of 7:3 to prepare a chitosan/polyethylene oxide spinning solution, wherein the concentration of the chitosan/polyethylene oxide spinning solution is 4 wt%.
6. The method for preparing the infection-preventing composite layer medical dressing according to claim 2, wherein: in the step 2, the electrostatic spinning conditions are as follows: the voltage is 15-20kV, the distance between the spinneret tip and the receiver is 10-15cm, the flow rate of the injection pump is 0.5-1mL/h, the electrostatic spinning is carried out for 6-10h, the fiber filaments are peeled off from the aluminum foil, and the aluminum foil is placed in a drying oven for drying and storage.
7. The method for preparing the infection-preventing composite layer medical dressing according to claim 2, wherein: in the step 3, the preparation method of the crosslinking treatment is disclosed: and soaking the double-layer nanofiber membrane into an EDC-NHS mixed solution, crosslinking for 1-2h, then cleaning with deionized water, and drying to obtain the infection-preventing composite layer medical dressing.
8. An anti-infection composite layer medical dressing is characterized in that: the medical dressing is prepared according to any one of claims 1 to 7.
9. An infection-preventing composite layer medical dressing prepared by the method of any one of claims 1 to 7 for use in the field of tissue engineering.
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