CN213761780U

CN213761780U - Dedicated filtration equipment of praziquantel intermediate

Info

Publication number: CN213761780U
Application number: CN202021635851.0U
Authority: CN
Inventors: 侯鹏翼
Original assignee: Xiamen Weijia Pharmaceutical Co ltd
Current assignee: Xiamen Weijia Pharmaceutical Co ltd
Priority date: 2020-08-10
Filing date: 2020-08-10
Publication date: 2021-07-23
Anticipated expiration: 2030-08-10

Abstract

The utility model discloses a dedicated filtration equipment of praziquantel midbody, including A reation kettle, the inside diapire front side through connection of A reation kettle has first drain pipe, the first filter screen of first drain pipe bottom fixedly connected with, first filter screen bottom fixedly connected with second drain pipe, B reation kettle bottom front side rear end through connection has the third drain pipe, third drain pipe outside contact is connected with condensing equipment, the one end contact that B reation kettle was kept away from to the third drain pipe is connected with the receipts box, fixedly connected with second filter screen in the middle of the receipts box inner wall. Heating and stirring the crude praziquantel product in the reaction kettle A to dissolve the crude praziquantel product in an ethanol solution, filtering out impurities insoluble in ethanol by using a first filter screen, heating the filtered crude praziquantel product in the reaction kettle B to volatilize ethanol in a certain proportion, cooling by using a condenser pipe to obtain a solution, filtering, and obtaining a fine praziquantel product on a second filter screen.

Description

Dedicated filtration equipment of praziquantel intermediate

Technical Field

The utility model mainly relates to a praziquantel preparation technical field, concretely relates to dedicated filtration equipment of praziquantel intermediate.

Background

Praziquantel is an anthelmintic for humans and animals, and is used for the treatment of tapeworm and trematode. The fluke, the Chinese liver fluke and the cestode (particularly effective) are the medicines on the basic medicine standard list of the world health organization and are one of the most important medicines for basic public health in the world.

At present, no special filtering equipment is used for filtering a praziquantel intermediate to obtain a fine praziquantel product in a praziquantel production process, so that a large amount of reagents are consumed for obtaining the fine praziquantel product, and the obtained purity is greatly inferior.

SUMMERY OF THE UTILITY MODEL

The utility model mainly provides a dedicated filtration equipment of praziquantel midbody for solve the technical problem who provides among the above-mentioned background art.

The utility model provides a technical scheme that above-mentioned technical problem adopted does:

a special filter equipment for praziquantel intermediate comprises an A reaction kettle, wherein an inlet is connected in the middle of the rear side of the top of the A reaction kettle in a penetrating manner, a third rotating wheel is connected in the middle of the top of the A reaction kettle in a rotating manner, an engine is connected in the top of the third rotating wheel in a rotating manner, a second rotating wheel is meshed at the front end of the third rotating wheel, a first rotating column is fixedly connected in the middle of the bottom of the second rotating wheel and penetrates through the top wall inside the A reaction kettle, a plurality of first heating columns are connected in the lower portion of the first rotating column in a penetrating manner, a first rotating wheel is meshed at the rear end of the third rotating wheel, a second rotating column is fixedly connected in the middle of the bottom of the first rotating wheel and penetrates through the top wall inside the A reaction kettle, a plurality of second heating columns are connected in a penetrating manner at the lower portion of the second rotating column, an A temperature sensor is fixedly connected in the middle of the rear end of the bottom wall inside the A reaction kettle, the front side of the bottom wall in the reaction kettle A is connected with a first liquid outlet pipe in a penetrating way, the bottom of the first liquid outlet pipe is fixedly connected with a first filter screen, the bottom of the first filter screen is fixedly connected with a second liquid outlet pipe, the bottom of the second liquid outlet pipe is connected with a B reaction kettle in a penetrating way, a first air outlet pipe is penetratingly connected with the middle of the front end of the top of the B reaction kettle, a second air outlet pipe is fixedly connected with the top of the front end of the first air outlet pipe, the middle of the bottom wall of the reaction kettle B is fixedly connected with a heating rod, the front side of the rear end of the bottom wall of the reaction kettle B is fixedly connected with a temperature sensor B, the rear end of the front side of the bottom of the reaction kettle B is connected with a third liquid outlet pipe in a penetrating way, the outside of the third liquid outlet pipe is connected with a condensing device in a contact way, one end of the third liquid outlet pipe, which is far away from the B reaction kettle, is in contact connection with a material receiving box, and a second filter screen is fixedly connected in the middle of the inner wall of the material receiving box.

The front end of the second air outlet pipe is fixedly connected with a filter screen, the heating temperature of the first heating column and the second heating column is thirty degrees to forty degrees, and the heating temperature of the heating rod is sixty degrees to seventy degrees.

The first filter screen material is gauze, first drain pipe top is equipped with switching device.

The water inlet of the condensing device is positioned on the long pipe at the rear end of the condensing device, and the water outlet of the condensing device is positioned on the short pipe at the front end of the condensing device.

The A temperature sensor is connected with a first heating column through a wire, the A temperature sensor is connected with a second heating column through a wire, and the B temperature sensor is connected with a heating rod through a wire.

The second filter screen is a microporous membrane filter core, and the second filter screen is provided with a drying device.

Compared with the prior art, the beneficial effects of the utility model are that:

the utility model discloses a add the praziquantel crude heating stirring and dissolve in ethanol solution at A reation kettle, because first: praziquantel is easily dissolved in ethanol solution; secondly, the method comprises the following steps: the boiling point of the ethanol is far lower than that of the praziquantel, then impurities which are insoluble in the ethanol are filtered by utilizing the first filter screen, the ethanol enters the reaction kettle B and is heated to volatilize ethanol in a certain proportion, the concentration of the praziquantel is increased in an ethanol solution, the temperature is reduced by utilizing the condenser pipe, a method of feeding the water into the condenser pipe and discharging the water from the condenser pipe is adopted, the temperature of the solution is reduced quickly, the utilization rate of cold water is high, after the temperature is reduced, the solution is filtered, a praziquantel fine product can be obtained on the second filter screen, and the ethanol obtained at the bottom of the material collecting box can be reused selectively.

The present invention will be explained in detail with reference to the drawings and specific embodiments.

Drawings

FIG. 1 is a schematic view of the overall structure of the present invention;

FIG. 2 is a schematic view of the cross-sectional structure of the reaction vessel B of the present invention;

fig. 3 is the schematic view of the sectional structure of the reaction kettle a of the present invention.

In the figure: 1. a first rotating wheel; 2. a liquid inlet; 3. a third rotating wheel; 4. a second rotating wheel; 5. a, a reaction kettle; 6. a first liquid outlet pipe; 7. a second liquid outlet pipe; 8. a first air outlet pipe; 9. a second air outlet pipe; 10. a third liquid outlet pipe; 11. a condensing unit; 12. a second filter screen; 13. a material receiving box; 14. an engine; 15. a first filter screen; 16. b, a reaction kettle; 17. A heating rod; 18. b, a temperature sensor; 19. a first spin column; 20. a first heating column; 21. a second heating column; 22. a, a temperature sensor; 23. a second spin column.

Detailed Description

In order to facilitate understanding of the present invention, the present invention will be described more fully with reference to the accompanying drawings, in which several embodiments of the present invention are shown, but the present invention can be implemented in different forms, and is not limited to the embodiments described in the text, but rather, these embodiments are provided to make the disclosure of the present invention more thorough and comprehensive.

It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may be present, and when an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present, as the terms "vertical", "horizontal", "left", "right" and the like are used herein for descriptive purposes only.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs, and the use of the term knowledge in the specification of the present invention is for the purpose of describing particular embodiments and is not intended to limit the present invention, and the term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.

Please refer to fig. 1-3, a special filtering apparatus for praziquantel intermediate comprises an a reaction kettle 5, a liquid inlet 2 is connected to the middle of the rear side of the top of the a reaction kettle 5 in a penetrating manner, a third rotating wheel 3 is connected to the middle of the top of the a reaction kettle 5 in a rotating manner, an engine 14 is connected to the top of the third rotating wheel 3 in a rotating manner, a second rotating wheel 4 is engaged with the front end of the third rotating wheel 3, a first rotating column 19 is fixedly connected to the middle of the bottom of the second rotating wheel 4, the first rotating column 19 penetrates through the top wall inside the a reaction kettle 5, a plurality of first heating columns 20 are connected to the lower portion of the first rotating column 19 in a penetrating manner, a first rotating wheel 1 is engaged with the rear end of the third rotating wheel 3, a second rotating column 23 is fixedly connected to the middle of the bottom of the first rotating wheel 1, the second rotating column 23 penetrates through the top wall inside the a reaction kettle 5, a plurality of second heating columns 21 are connected to the lower portion of the second rotating column 23, a temperature sensor 22 is fixedly connected in the middle of the rear end of the inner bottom wall of an A reaction kettle 5, a first liquid outlet pipe 6 is connected in a penetrating way on the front side of the inner bottom wall of the A reaction kettle 5, a first filter screen 15 is fixedly connected at the bottom of the first liquid outlet pipe 6, a second liquid outlet pipe 7 is fixedly connected at the bottom of the first filter screen 15, a B reaction kettle 16 is connected at the bottom of the second liquid outlet pipe 7 in a penetrating way, a first gas outlet pipe 8 is connected in a penetrating way in the middle of the front end of the top of the B reaction kettle 16, a second gas outlet pipe 9 is fixedly connected at the top of the front end of the first gas outlet pipe 8, a heating rod 17 is fixedly connected in the middle of the inner bottom wall of the B reaction kettle 16, a B temperature sensor 18 is fixedly connected at the front side of the rear end of the bottom wall of the B reaction kettle 16, a third liquid outlet pipe 10 is connected in a penetrating way at the rear end of the bottom of the B reaction kettle 16, a condensing device 11 is in contact way outside of the third liquid outlet pipe 10, a material receiving box 13 is connected in a contact way far away from one end of the B reaction kettle 16, the middle of the inner wall of the material receiving box 13 is fixedly connected with a second filter screen 12.

9 front end fixedly connected with filter screens of second outlet duct,

first heating column

20 and 21 heating temperature of second heating column are thirty degrees to forty degrees, can promote the solubility of praziquantel in after the solution heating, heating rod 17 heating temperature is sixty degrees to seventy degrees, the boiling point of ethanol is 78.3 degrees, the selection heating temperature is the volatilization of sixty degrees to seventy degrees acceleration of ethanol, promote the filter time, 15 materials of first filter screen are the gauze, 6 tops of first drain pipe are equipped with switching device.

The water inlet of the condensing device 11 is positioned on the long pipe at the rear end of the condensing device 11, the water outlet is positioned on the short pipe at the front end of the condensing device 11, and the water heated by the steam is higher in temperature due to the lower water temperature at the water inlet; the warmer water will automatically flow upward due to the reduced density, which helps to circulate the cooling water. The condenser tube is usually used in a flask for experiment under reflux or a distillation flask for collecting condensed liquid. Condensation of the vapor occurs on the inner wall of the inner tube. The space enclosed by the inner and outer tubes is used as the water-flowing area for absorbing the heat of steam and removing the heat.

The switch of first heating post 20 and second heating post 21 is controlled to A temperature-sensing ware 22, the switch of B temperature-sensing ware 18 control heating rod 17, first heating post 20 rotates the stirring along with first column 19, second heating post 21 rotates the stirring along with second column 23, makes first heating post 20 and second heating post 21 can play the effect of stirring when heating, because remove the heating simultaneously, makes liquid thermally equivalent.

The utility model discloses a concrete operation as follows:

firstly, a user pours a praziquantel intermediate, namely a praziquantel crude product and organic solution ethanol into an A reaction kettle 5 from a liquid inlet 2, electrifys an engine 14 to enable the engine 14 to operate and drive a third rotating wheel 3 to rotate, the third rotating wheel 3 drives a first rotating wheel 1 and a second rotating wheel 4 to rotate, so that a first heating column 20 and a second heating column 21 rotate, the first heating column 20 and the second heating column 21 start to heat simultaneously, a temperature sensor 22 detects the temperature of the A reaction kettle 5 in real time, a first liquid outlet pipe 6 is opened after ten minutes, the solution is filtered by a first filter screen 15, the filtered solution enters a B reaction kettle 16 through a second liquid outlet pipe 7, a heating rod 17 starts to heat simultaneously, a B temperature sensor 18 detects the temperature in the B reaction kettle 16 in real time, the solution is led out after fifteen minutes, and is cooled by a condensing device 11 on the outer surface of a third liquid outlet pipe 10, obtaining the praziquantel competitive product.

The present invention has been described above with reference to the accompanying drawings, and it is obvious that the present invention is not limited by the above-mentioned manner, if the method and the technical solution of the present invention are adopted, the present invention can be directly applied to other occasions without substantial improvement, and the present invention is within the protection scope of the present invention.

Claims

1. A dedicated filtration equipment of praziquantel intermediate, including A reation kettle (5), its characterized in that: the device is characterized in that a liquid inlet (2) is connected in the middle of the rear side of the top of the A reaction kettle (5) in a penetrating manner, a third rotating wheel (3) is connected in the middle of the top of the A reaction kettle (5) in a rotating manner, an engine (14) is connected in the top of the third rotating wheel (3) in a rotating manner, a second rotating wheel (4) is meshed at the front end of the third rotating wheel (3), a first rotating column (19) is fixedly connected in the middle of the bottom of the second rotating wheel (4), the first rotating column (19) penetrates through the inner top wall of the A reaction kettle (5), a plurality of first heating columns (20) are connected in the lower portion of the first rotating column (19) in a penetrating manner, a first rotating wheel (1) is meshed at the rear end of the third rotating wheel (3), a second rotating column (23) is fixedly connected in the middle of the bottom of the first rotating wheel (1), and the second rotating column (23) penetrates through the inner top wall of the A reaction kettle (5), the lower part of the second rotating column (23) is connected with a plurality of second heating columns (21) in a penetrating manner, the middle of the rear end of the inner bottom wall of the A reaction kettle (5) is fixedly connected with an A temperature sensor (22), the front side of the inner bottom wall of the A reaction kettle (5) is connected with a first liquid outlet pipe (6) in a penetrating manner, the bottom of the first liquid outlet pipe (6) is fixedly connected with a first filter screen (15), the bottom of the first filter screen (15) is fixedly connected with a second liquid outlet pipe (7), the bottom of the second liquid outlet pipe (7) is connected with a B reaction kettle (16) in a penetrating manner, the middle of the front end of the top of the B reaction kettle (16) is connected with a first air outlet pipe (8) in a penetrating manner, the top of the front end of the first air outlet pipe (8) is fixedly connected with a second air outlet pipe (9), the middle of the inner bottom wall of the B reaction kettle (16) is fixedly connected with a heating rod (17), the front side of the rear end of the bottom wall of the B reaction kettle (16) is fixedly connected with a B temperature sensor (18), b reation kettle (16) bottom front side rear end through connection has third drain pipe (10), third drain pipe (10) outside contact is connected with condensing equipment (11), the one end contact that B reation kettle (16) were kept away from in third drain pipe (10) is connected with material collecting box (13), fixedly connected with second filter screen (12) in the middle of material collecting box (13) inner wall.

2. The special filtering equipment for the praziquantel intermediate as claimed in claim 1, wherein: the front end of the second air outlet pipe (9) is fixedly connected with a filter screen, the heating temperatures of the first heating column (20) and the second heating column (21) are thirty degrees to forty degrees, and the heating temperature of the heating rod (17) is sixty degrees to seventy degrees.

3. The special filtering equipment for the praziquantel intermediate as claimed in claim 1, wherein: the first filter screen (15) is made of gauze, and a switch device is arranged at the top of the first liquid outlet pipe (6).

4. The special filtering equipment for the praziquantel intermediate as claimed in claim 1, wherein: the water inlet of the condensing device (11) is positioned on the short pipe at the front end of the condensing device (11), and the water outlet is positioned on the long pipe at the rear end of the condensing device (11).

5. The special filtering equipment for the praziquantel intermediate as claimed in claim 1, wherein: a temperature-sensing ware (22) is connected with first heating post (20) through the wire, A temperature-sensing ware (22) is connected with second heating post (21) through the wire, B temperature-sensing ware (18) is connected with heating rod (17) through the wire.

6. The special filtering equipment for the praziquantel intermediate as claimed in claim 1, wherein: the second filter screen (12) is a microporous membrane filter element, and the second filter screen (12) is provided with a drying device.