CN212663478U - Device for preparing uniform single emulsion drops in high flux - Google Patents
Device for preparing uniform single emulsion drops in high flux Download PDFInfo
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- CN212663478U CN212663478U CN202021744641.5U CN202021744641U CN212663478U CN 212663478 U CN212663478 U CN 212663478U CN 202021744641 U CN202021744641 U CN 202021744641U CN 212663478 U CN212663478 U CN 212663478U
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Abstract
The utility model discloses a device for preparing uniform single emulsion drops with high flux, which comprises a base, a cavity, a capillary structure and an actuating unit; the base is provided with a dispersed phase liquid channel, the base is also provided with a disturbance interface communicated with the dispersed phase liquid channel, the disturbance interface is packaged, and the actuating unit inputs disturbance through the disturbance interface; the capillary structure is arranged at the bottom end of the base, and the top end of the capillary structure is communicated with the outlet end of the dispersed phase liquid channel; the cavity is hermetically arranged at the bottom end of the base, and the capillary structure is arranged in the cavity; the cavity is provided with a driving phase inlet, the driving phase inlet is used for inputting driving phase liquid into the cavity, and the driving phase liquid and the dispersed phase liquid are not dissolved with each other; the bottom end of the cavity is provided with a discharge hole which is concentric with the outlet end of the capillary structure. The control of jet flow crushing is realized through the frequency of a disturbance signal sent by the actuating unit, the high-flux production of single emulsion drops is realized, and the uniformity of the sizes of the single emulsion drops is ensured.
Description
Technical Field
The utility model belongs to the technical field of single emulsion drop preparation technique and specifically relates to a device of even single emulsion drop of high flux preparation is related to.
Background
Single emulsion droplets of micron and submicron size are of great importance in various scientific and engineering applications. Over the past few decades, emerging microfluidic technologies have been developed to produce monodisperse droplets, such as microfluidic chips, glass microcapillaries, and flow focusing technologies.
In scientific research and practical application, the preparation of single emulsion droplets is carried out in a droplet mode, the flux is small, and the preparation efficiency is low. If the flux is increased, the preparation of single emulsion droplets is converted from a droplet mode to a jet mode, the size distribution of the droplets in the jet mode is widened, and the breaking length of the jet has certain randomness.
Therefore, how to realize high-throughput production of single emulsion droplets and ensure uniform size of the single emulsion droplets is a technical problem to be solved urgently by those skilled in the art.
SUMMERY OF THE UTILITY MODEL
In view of this, the utility model aims at providing a device of even single emulsion drop is prepared to high flux, can realize the single emulsion drop of high-throughput production, and guarantees that the size of single emulsion drop is even.
In order to achieve the above object, the present invention provides the following solutions:
a device for preparing uniform single emulsion drops in high flux comprises a base, a cavity, a capillary structure and an actuating unit;
the base is provided with a dispersed phase liquid channel, the inlet end of the dispersed phase liquid channel is used for inputting dispersed phase liquid, the base is further provided with a disturbance interface communicated with the dispersed phase liquid channel, the disturbance interface is packaged, and the actuating unit inputs disturbance through the packaged disturbance interface;
the outlet end of the dispersed phase liquid channel is arranged at the bottom end of the base, the capillary structure is arranged at the bottom end of the base, and the top end of the capillary structure is communicated with the outlet end of the dispersed phase liquid channel;
the cavity is hermetically arranged at the bottom end of the base, and the capillary structure is arranged in the cavity;
the cavity is provided with a driving phase inlet, the driving phase inlet is used for inputting driving phase liquid into the cavity, and the driving phase liquid and the dispersed phase liquid are not dissolved with each other;
the bottom end of the cavity is provided with a discharge hole, and the discharge hole is concentric with the outlet end of the capillary structure.
In a particular embodiment, the diameter of the discharge orifice is 2 times the diameter of the single emulsion droplet to be prepared;
the inner diameter of the outlet end of the capillary structure is equivalent to the diameter of the discharge hole, and the distance from the outlet end of the capillary structure to the discharge hole is equivalent to the inner diameter of the outlet end of the capillary structure;
and/or
The diameter of the single emulsion drop to be prepared is calculated according to the formula D ═ (6Q/pi f)1/3，
Q is the flow rate of the dispersed phase liquid,
f is the excitation frequency input by the actuation unit to the perturbation interface.
In another embodiment, the high throughput apparatus for preparing uniform single emulsion droplets further comprises a substrate and a support column;
the supporting column is installed at the top end of the base, the substrate is installed at the top end of the supporting column, the actuating unit is installed on the substrate, and the actuating end of the actuating unit inputs disturbance to the disturbance interface.
In another specific embodiment, the actuation unit comprises a signal generator, a power amplifier, and an actuator;
the signal generator is in signal connection with the power amplifier, and the power amplifier is in signal connection with the actuator;
and the disturbance signal sent by the signal generator is amplified by the power amplifier and then output to the disturbance interface through the actuator.
In another embodiment, the perturbation interface is encapsulated by a thin film.
In another specific embodiment, the high-throughput apparatus for preparing uniform single emulsion droplets further comprises a first syringe pump in fluid connection with the dispersed phase inlet for injecting the dispersed phase liquid into the dispersed phase inlet;
the device for preparing uniform single emulsion droplets at high flux also comprises a second injection pump which is in conductive connection with the driving phase inlet and is used for injecting the driving phase liquid into the driving phase inlet,
or
The device for preparing uniform single emulsion drops with high flux also comprises a power pump and a buffer,
the power pump is in conductive connection with the buffer, the buffer is in conductive connection with the driving phase inlet,
the power pump is used for conveying the driving phase liquid into the buffer, and the buffer is used for buffering the driving phase liquid and conveying the driving phase liquid into the cavity.
In another specific embodiment, the high throughput apparatus for preparing uniform single emulsion droplets further comprises a reservoir;
the liquid storage tank is used for storing the driving phase liquid;
the power pump is a peristaltic pump, and the buffer is a buffer bottle.
In another specific embodiment, the device for preparing uniform single emulsion droplets in high flux further comprises an image acquisition module,
the image acquisition module is used for acquiring an image signal of the single emulsion drop dripped from the discharge hole;
and/or
The device for preparing uniform single emulsion drops in high flux also comprises a drop collecting module,
the liquid drop collecting module is arranged at the bottom end of the base and used for collecting single emulsion drops dropping from the discharge hole.
According to the utility model discloses an each embodiment can make up as required wantonly, and the embodiment that obtains after these combinations is also in the utility model discloses the scope is the utility model discloses a part of the concrete implementation mode.
Without being limited to any theory, from the above disclosure, the utility model discloses a device for preparing even single emulsion liquid drop with high flux, during the use, drive phase liquid is let in to the cavity earlier continuously to form stable drive phase flow field, then, disperse phase liquid is let in to disperse phase liquid channel's entry end continuously, actuating unit inputs the disturbance through the disturbance interface and gives the disperse phase liquid in the disperse phase liquid channel, realize the broken control to disperse phase liquid efflux, disperse phase liquid is discharged from capillary structure's exit end, through drive phase liquid parcel, discharge from the discharge hole, form single emulsion liquid drop. The control of jet flow crushing is realized through the frequency of a disturbance signal sent by the actuating unit, the high-flux production of single emulsion drops is realized, and the uniformity of the sizes of the single emulsion drops is ensured.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without any novelty.
FIG. 1 is a schematic structural diagram of an apparatus for preparing uniform single emulsion droplets at high flux according to the present invention;
FIG. 2 is a partially enlarged schematic view of FIG. 1;
fig. 3 is a schematic diagram of a local enlargement of a disturbance interface provided by the present invention;
fig. 4 is a typical droplet micrograph provided by the present invention;
FIG. 5 is a graph of particle size versus frequency provided by the present invention;
FIG. 6 is a schematic diagram of an apparatus for high throughput preparation of uniform single emulsion droplets provided by the present invention;
fig. 7 is a schematic view of the connection structure of the power pump, the buffer and the liquid storage tank provided by the present invention.
Wherein, in fig. 1-7:
the device comprises a base 1, a cavity 2, a capillary structure 3, an actuating unit 4, a disperse phase liquid channel 101, a disturbance interface 102, a driving phase inlet 201, a discharge hole 202, a substrate 5, a support column 6, a signal generator 401, a power amplifier 402, an actuator 403, a power pump 7, a buffer 8, a liquid storage tank 9, an image acquisition module 10, a camera 1001, a computer 1002, a liquid drop collection module 11, a sealing ring 12, a first injection pump 13, a second injection pump 14 and a strobe light 15.
Detailed Description
In order to make the technical solution of the present invention better understood by those skilled in the art, the present invention will be further described in detail with reference to fig. 1 to 7 and the detailed description.
As shown in fig. 1, the utility model discloses a device for preparing uniform single emulsion drop with high flux, wherein, the device for preparing uniform single emulsion drop with high flux includes base 1, cavity 2, capillary structure 3 and actuating unit 4.
The base 1 is provided with a dispersed phase liquid channel 101, an inlet end of the dispersed phase liquid channel 101 is used for inputting dispersed phase liquid, the base 1 is further provided with a disturbance interface 102 communicated with the dispersed phase liquid channel 101, the disturbance interface 102 is packaged, specifically, the disturbance interface 102 is packaged through a film, so that disturbance can be input to the disturbance interface 102.
The disperse phase liquid channel 101 comprises a first channel and a second channel, the second channel is vertically arranged, the first channel is horizontally arranged or arranged at a certain inclination angle with the horizontal direction, the disturbance interface 102 is arranged at the upstream of the disperse phase liquid channel 101, specifically, the disturbance interface 102 is positioned at the conduction position of the first channel and the second channel, and the bottom end of the disturbance interface 102 is in a conical shape with a gradually reduced cross section, so that the disperse phase liquid conveyed by the first channel is buffered conveniently.
The actuation unit 4 inputs a disturbance through the encapsulated disturbance interface 102. The structure of the actuation unit 4 is not limited, and may be any structure capable of achieving output disturbance.
The exit end of disperse phase liquid channel 101 is arranged at the bottom end of base 1, capillary structure 3 is hermetically mounted at the bottom end of base 1, and the top end of capillary structure 3 is communicated with the exit end of disperse phase liquid channel 101. Specifically, the capillary structure 3 is a capillary tube, the capillary tube is in an inverted cone shape, and the size of the top end of the inner cavity of the capillary tube is larger than the diameter size of the outlet end of the dispersed phase liquid channel 101, that is, the inner cavity of the capillary tube surrounds the outlet end of the dispersed phase liquid channel 101.
The cavity 2 is hermetically arranged at the bottom end of the base 1, and the capillary structure 3 is arranged in the cavity 2. Specifically, the top wall of the cavity 2 is provided with a first limiting step and a second limiting step in sequence from outside to inside, and correspondingly, the bottom end of the base 1 is provided with a third limiting step matched with the first limiting step, a fourth limiting step matched with the second limiting step and a fifth limiting step in sequence from outside to inside. The top wall of the first limiting step and the third limiting step have a certain gap, and the side wall of the first limiting step and the side wall of the fourth limiting step are tightly attached to limit the cavity 2 and the base 1. The bottom end of the second limiting step is provided with a groove, a sealing ring 12 is arranged in the groove and seals the horizontal planes of the second limiting step and the fourth limiting step, and the side wall of the second limiting step is in sealing connection with the side wall of the fifth limiting step.
The cavity 2 is provided with a driving phase inlet 201, the driving phase inlet 201 is used for inputting a driving phase liquid into the cavity 2, and the driving phase liquid and a dispersed phase liquid are not dissolved with each other, for example, one of the driving phase liquid and the dispersed phase liquid is oil, and the other is water.
The bottom end of the cavity 2 is provided with a discharge hole 202, and the discharge hole 202 is concentric with the outlet end of the capillary structure 3, so that smooth discharge of single emulsion droplets is ensured.
The utility model discloses a device of even single emulsion drop is prepared to high flux, during the use, continuously let in drive phase liquid in cavity 2 earlier, form the steady drive phase flow field, then, continuously let in disperse phase liquid to disperse phase liquid channel 101's entry end, actuating unit 4 inputs disturbance signal through disturbance interface 102 and gives the disperse phase liquid in the disperse phase liquid channel 101, the realization is to the broken control of disperse phase liquid efflux, disperse phase liquid is discharged from capillary structure 3's exit end, through drive phase liquid parcel, discharge from discharge hole 202, form single emulsion drop. The preparation of different single emulsion drops is realized through the frequency of the disturbance signal sent by the actuating unit 4, and the adjustment and control of the single emulsion drops are realized. In addition, the breaking frequency of the jet flow is controlled by the actuating unit 4, so that the defect that the flux cannot be considered by depending on a drop mode in the existing microfluidics for preparing uniform liquid drops can be effectively overcome.
In some of the embodiments, the device for preparing uniform single emulsion droplets at high throughput further comprises a base plate 5 and a support column 6, the support column 6 is mounted on the top end of the base 1, the base plate 5 is mounted on the top end of the support column 6, the actuating unit 4 is mounted on the base plate 5, and the actuating end of the actuating unit 4 inputs the disturbance to the disturbance interface 102. Specifically, the support column 6 is welded to the base 1, and may be detachably attached to the base 1 by a screw or the like. The substrate 5 may be directly welded to the support column 6, or may be detachably attached to the support column 6 by screws or the like.
In some of these embodiments, the present invention discloses that the diameter of the discharge opening 202 is 2 times the diameter of the single emulsion droplets to be prepared, the inner diameter Di of the outlet end of the capillary structure 3 corresponds to the diameter d of the discharge opening 202, and the distance H from the outlet end of the capillary structure 3 to the discharge opening 202 corresponds to the inner diameter Di of the outlet end of the capillary structure 3. Under the condition of meeting the above conditions, the prepared single emulsion is uniform in dripping. As shown in fig. 2. It should be noted that the equivalence here may be equal, slightly larger or slightly smaller.
Further, the utility model discloses a diameter calculation formula of single emulsion drop is D ═ 6Q/pi f)1/3Where Q is the flow rate of the dispersed phase liquid and f is the excitation frequency input by the actuation unit 4 to the perturbation interface 102. That is, the control of the volume of the single emulsion drop is realized by controlling the flow rate of the dispersed phase liquid and the excitation frequency of the disturbance interface 102 input by the actuating unit 4.
In some of the embodiments, it is specifically disclosed that the actuation unit 4 comprises a signal generator 401, a power amplifier 402 and an actuator 403, the signal generator 401 is in signal connection with the power amplifier 402, and the power amplifier 402 is in signal connection with the actuator 403; the disturbance signal generated by the signal generator 401 is amplified by the power amplifier 402 and then output to the disturbance interface 102 through the actuator 403.
The perturbation signal output by the signal generator 401 may be a variety of different perturbation signals, such as a sine wave, a sawtooth wave, a square wave, and the like. The actuator may take many forms, for example, a piezoelectric ceramic, an electromagnetic oscillator, or the like, which may provide the vibration.
In some embodiments, the apparatus for preparing uniform single emulsion droplets at high flux further comprises a power pump 7 and a buffer 8, the power pump 7 is in communication with the buffer 8, the buffer 8 is in communication with the driving phase inlet 201, the power pump 7 is used for delivering the driving phase liquid into the buffer 8, and the buffer 8 is used for buffering the driving phase liquid and delivering the driving phase liquid into the cavity 2. The pulse flow of the power pump 7 is attenuated after passing through the buffer 8, and is not influenced by the flow rate of the driving phase liquid within a certain range in the single emulsion droplet particle size influence parameters. Specifically, the utility model discloses a power pump 7 is the peristaltic pump, and buffer 8 is the cushion flask. The power pump 7 is not limited to the peristaltic pump described above, and may be another type of pump. The buffer bottle is not limited to the bottle structure, but may be other structures.
Note that the input of the dispersed phase liquid and the drive phase liquid may be realized by using syringe pumps as they are, and as shown in fig. 6, the syringe pump for injecting the dispersed phase is referred to as a first syringe pump 13 and the syringe pump for injecting the drive phase is referred to as a second syringe pump 14.
Further, the device for high throughput preparation of uniform single emulsion droplets further comprises a reservoir 9, the reservoir 9 being used to drive a reservoir of phase liquid. Only the driving phase liquid needs to be added into the liquid storage tank 9 under the condition that a large amount of driving phase liquid is needed, and the method has important practical value when single emulsion liquid drops are continuously prepared in a large scale.
In some embodiments, the apparatus for preparing uniform single emulsion droplets at high throughput further comprises an image acquisition module 10, wherein the image acquisition module 10 is used for acquiring image signals of the single emulsion droplets dripped from the discharge hole 202.
Specifically, the image acquisition module 10 includes an image acquirer and a controller, the controller is in signal connection with the image acquirer, and the image acquirer is located below the cavity 2 and used for acquiring image information and transmitting the acquired information to the controller. The image acquisition device is a camera 1001, a video camera, or the like, and the controller is a computer 1002 or the like.
In order to facilitate the signal of gathering the single emulsion drop, the utility model discloses a device of even single emulsion drop of high flux preparation still includes strobe light 15, and strobe light 15 sets up in the below of cavity 2, is located one side of single emulsion drip.
Further, the utility model discloses a device of even single emulsion liquid drop is prepared to high flux still includes liquid drop collection module 11, and base 1's bottom is arranged in to liquid drop collection module 11 for collect the single emulsion liquid drop that discharge hole 202 dripped. Specifically, the droplet collection module 11 includes a container, and a collection liquid is contained in the container, and the collection liquid is immiscible with the driving phase liquid.
The utility model discloses an initial disturbance (including frequency and amplitude) of actuating unit 4 active control efflux, the fluid that flows out from the upper reaches is led by plus disturbance, and the crushing frequency of efflux can be controlled to the disturbance. The utility model discloses can the fluidic crushing process of accurate control, can control the particle diameter of liquid drop and fluidic length, in addition, through adjusting the frequency interval of applying the disturbance of natural frequency of breakage adjustment, use more extensively. The utility model discloses can also be applicable to the fluid of different attributes (viscosity, interfacial tension), accord with the condition to different fluid among the various practical application very much.
The utility model discloses device of even single emulsion drop of well high flux preparation owing to adopt actuating unit 4 control initial disturbance, can realize the accurate control of efflux crushing process, especially control fluidic broken frequency, and the wide application is in various liquid drop micro-fluidic technologies moreover, and can effectively overcome current micro-fluidic for preparing even liquid drop and rely on the shortcoming that the flux can not be compromise to the drop mode, is particularly suitable for being used for the scene that needs utilize the little liquid drop of efflux mode and a large amount of preparation.
In the present invention, "first", "second", etc. are all distinguished in description, and have no other special meaning.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (8)
1. A device for preparing uniform single emulsion drops in high flux is characterized by comprising a base, a cavity, a capillary structure and an actuating unit;
the base is provided with a dispersed phase liquid channel, the inlet end of the dispersed phase liquid channel is used for inputting dispersed phase liquid, the base is further provided with a disturbance interface communicated with the dispersed phase liquid channel, the disturbance interface is packaged, and the actuating unit inputs disturbance through the packaged disturbance interface;
the outlet end of the dispersed phase liquid channel is arranged at the bottom end of the base, the capillary structure is hermetically arranged at the bottom end of the base, and the top end of the capillary structure is communicated with the outlet end of the dispersed phase liquid channel;
the cavity is hermetically arranged at the bottom end of the base, and the capillary structure is arranged in the cavity;
the cavity is provided with a driving phase inlet, the driving phase inlet is used for inputting driving phase liquid into the cavity, and the driving phase liquid and the dispersed phase liquid are not dissolved with each other;
the bottom end of the cavity is provided with a discharge hole, and the discharge hole is concentric with the outlet end of the capillary structure.
2. High throughput uniform single emulsion droplet preparation apparatus according to claim 1 wherein the diameter of said discharge orifice is 2 times the diameter of the single emulsion droplet to be prepared;
the inner diameter of the outlet end of the capillary structure is equivalent to the diameter of the discharge hole, and the distance from the outlet end of the capillary structure to the discharge hole is equivalent to the inner diameter of the outlet end of the capillary structure;
and/or
The diameter calculation formula of the single emulsion drop is D ═ (6Q/pi f)1/3，
Q is the flow rate of the dispersed phase liquid,
f is the excitation frequency input by the actuation unit to the perturbation interface.
3. The high throughput uniform single emulsion droplet preparation device of claim 1 further comprising a base plate and a support column;
the supporting column is installed at the top end of the base, the substrate is installed at the top end of the supporting column, the actuating unit is installed on the substrate, and the actuating end of the actuating unit inputs disturbance to the disturbance interface.
4. High throughput uniform single emulsion droplet preparation apparatus according to claim 1, wherein said actuation unit comprises a signal generator, a power amplifier and an actuator;
the signal generator is in signal connection with the power amplifier, and the power amplifier is in signal connection with the actuator;
and the disturbance signal sent by the signal generator is amplified by the power amplifier and then output to the disturbance interface through the actuator.
5. High throughput uniform single emulsion droplet preparation apparatus according to claim 4 wherein said disturbance interface is encapsulated by a thin film.
6. The device for high throughput preparation of uniform single emulsion droplets of claim 1, further comprising a first syringe pump in fluid connection with the dispersed phase inlet for injecting the dispersed phase liquid into the dispersed phase inlet;
the device for preparing uniform single emulsion droplets at high flux also comprises a second injection pump which is in conductive connection with the driving phase inlet and is used for injecting the driving phase liquid into the driving phase inlet,
or
The device for preparing uniform single emulsion drops with high flux also comprises a power pump and a buffer,
the power pump is in conductive connection with the buffer, the buffer is in conductive connection with the driving phase inlet,
the power pump is used for conveying the driving phase liquid into the buffer, and the buffer is used for buffering the driving phase liquid and conveying the driving phase liquid into the cavity.
7. The device for high throughput preparation of uniform single emulsion droplets of claim 6, further comprising a reservoir;
the liquid storage tank is used for storing the driving phase liquid;
the power pump is a peristaltic pump, and the buffer is a buffer bottle.
8. High throughput preparation of uniform single emulsion droplets according to any one of claims 1 to 7, further comprising an image acquisition module,
the image acquisition module is used for acquiring an image signal of the single emulsion drop dripped from the discharge hole;
and/or
The device for preparing uniform single emulsion drops in high flux also comprises a drop collecting module,
the liquid drop collecting module is arranged at the bottom end of the base and used for collecting single emulsion drops dropping from the discharge hole.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111841439A (en) * | 2020-08-19 | 2020-10-30 | 中国科学技术大学 | Device and method for preparing uniform single emulsion drops in high flux |
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| CN111841439A (en) * | 2020-08-19 | 2020-10-30 | 中国科学技术大学 | Device and method for preparing uniform single emulsion drops in high flux |
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