CN212663477U - Device for preparing uniform double-emulsion drops in high flux - Google Patents
Device for preparing uniform double-emulsion drops in high flux Download PDFInfo
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- CN212663477U CN212663477U CN202021744601.0U CN202021744601U CN212663477U CN 212663477 U CN212663477 U CN 212663477U CN 202021744601 U CN202021744601 U CN 202021744601U CN 212663477 U CN212663477 U CN 212663477U
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Abstract
The utility model discloses a device of even two emulsion drops of high flux preparation, including base, cavity, interior capillary structure, outer capillary structure, nuclear phase actuating unit and shell phase actuating unit. When the double-emulsion-type multi-phase liquid jet pump is used, the nuclear phase actuating unit inputs nuclear phase disturbance to the nuclear phase disturbance interface, the shell phase actuating unit inputs shell phase disturbance to the shell phase disturbance interface, nuclear phase liquid is discharged from the outlet end of the inner capillary structure, wrapped by shell phase liquid and discharged from the outer capillary structure, driving phase liquid is wrapped outside the shell phase liquid and discharged from the discharge hole to form a composite jet flow, and the shell phase liquid wraps the nuclear phase liquid and is broken down due to instability at the downstream to form double-emulsion droplets. The utility model discloses a nuclear phase actuating unit and shell phase actuating unit are respectively to nuclear phase liquid and shell phase liquid input disturbance, realize the control to the size of double emulsion drop, when having realized the double emulsion drop of high flux production, have guaranteed the monodispersity of double emulsion drop size.
Description
Technical Field
The utility model belongs to the technical field of two emulsion drop preparation technique and specifically relates to a device of even two emulsion drops of high flux preparation is related to.
Background
The double emulsion droplets are complex droplets with dispersed phase droplets wrapped with smaller droplets, and the outer droplets form a shielding layer around the inner droplets to effectively isolate the inner droplets from the continuous phase. Double emulsion droplets, which are different from single emulsion droplets, have more flexible structural features, due to their unique core-shell structure and material selectivity, have attracted increasing research interest to scientists. The encapsulation with double emulsion drops as templates can be effectively applied to the fields of encapsulation, transportation or controllable release, such as cells, biochemistry, catalysts, self-healing materials, carbonless copy paper, electronic ink, carbon dioxide adsorption and the like.
At present, when double emulsion droplets are produced at high flux, the droplet mode is generally required to be converted into a jet flow mode, so that the size distribution of the droplets is widened, and the breaking length of the jet flow is random to some extent.
Therefore, how to realize high-throughput production of double emulsion droplets and ensure uniform size of double emulsion droplets is a technical problem to be solved urgently by those skilled in the art.
SUMMERY OF THE UTILITY MODEL
In view of this, the utility model aims at providing a device of even double emulsion drop is prepared to high flux, can realize the double emulsion drop of high flux production, and guarantees that the size of double emulsion drop is even.
In order to achieve the above object, the present invention provides the following solutions:
a device for preparing uniform double emulsion drops in high flux comprises a base, a cavity, an inner capillary structure, an outer capillary structure, a nuclear phase actuating unit and a shell phase actuating unit;
the base is provided with a nuclear phase liquid channel, the inlet end of the nuclear phase liquid channel is used for inputting nuclear phase liquid, the inlet end of the inner capillary structure is in conduction connection with the outlet end of the nuclear phase liquid channel, the base is provided with a nuclear phase disturbance interface which is in conduction with the nuclear phase liquid channel, the nuclear phase disturbance interface is packaged, and the nuclear phase actuating unit inputs nuclear phase disturbance through the packaged nuclear phase disturbance interface;
the base is further provided with a shell phase liquid channel, the inlet end of the shell phase liquid channel is used for inputting shell phase liquid, the inlet end of the outer capillary structure is communicated with the outlet end of the shell phase liquid channel, the outer capillary structure is arranged around the inner capillary structure, the inner capillary structure and the outer capillary structure are concentrically arranged, the base is provided with a shell phase disturbance interface communicated with the shell phase liquid channel, the shell phase disturbance interface is packaged, and the shell phase actuating unit inputs shell phase disturbance through the packaged shell phase disturbance interface;
the cavity is hermetically arranged at the bottom end of the base, and the outer capillary structure is arranged in the cavity;
the cavity is provided with a driving phase inlet, the driving phase inlet is used for inputting driving phase liquid into the cavity, and the shell phase liquid is immiscible with the driving phase liquid and the nuclear phase liquid respectively;
the bottom end of the cavity is provided with a discharge hole, and the discharge hole is concentric with the outlet end of the outer capillary structure.
In a particular embodiment, the outlet end of the inner capillary structure is located above or below the outlet end of the outer capillary structure;
and/or
The diameter D of the double emulsion droplet to be prepared is (6Q/. pi.f)1/3，
Q＝Qo+Qi，
Wherein Q is the sum of the flow rates of the shell phase liquid and the core phase liquid,
Qothe flow rate of the shell phase is the flow rate of the shell phase,
Qithe flow rate of the shell phase is the flow rate of the shell phase,
f is the excitation frequency;
and/or
The diameter d of the inner core of the double emulsion droplet to be prepared is (6Q)i/πf)1/3，
Wherein Q isiThe flow rate of the shell phase is the flow rate of the shell phase,
f is the excitation frequency.
In another embodiment, the device for preparing uniform double emulsion droplets in high flux further comprises a nuclear phase substrate and a nuclear phase support column,
one end of the nuclear phase supporting column is installed on the base, the nuclear phase substrate is installed on the other end of the nuclear phase supporting column, the nuclear phase actuating unit is installed on the nuclear phase substrate, and the actuating end of the nuclear phase actuating unit inputs nuclear phase disturbance to the nuclear phase disturbance interface;
and/or
The device for preparing the uniform double emulsion drops in high flux also comprises a shell phase substrate and a shell phase supporting column,
one end of the shell phase supporting column is installed on the base, the shell phase substrate is installed on the other end of the shell phase supporting column, the shell phase actuating unit is installed on the shell phase substrate, and the actuating end of the shell phase actuating unit inputs shell phase disturbance to the shell phase disturbance interface.
In another embodiment, the nuclear phase actuation unit comprises a nuclear phase signal generator, a nuclear phase power amplifier and a nuclear phase actuator,
the nuclear phase signal generator is in signal connection with the nuclear phase power amplifier, the nuclear phase power amplifier is in signal connection with the nuclear phase actuator,
a nuclear phase disturbance signal sent by the nuclear phase signal generator is amplified by the nuclear phase power amplifier and then is output to the nuclear phase disturbance interface through the nuclear phase actuator;
and/or
The shell phase actuating unit comprises a shell phase signal generator, a shell phase power amplifier and a shell phase actuator,
the shell-phase signal generator is in signal connection with the shell-phase power amplifier, the shell-phase power amplifier is in signal connection with the shell-phase actuator,
and after being amplified by the shell phase power amplifier, the shell phase disturbance signal sent by the shell phase signal generator is output to the shell phase disturbance interface through the shell phase actuator.
In another embodiment, the core phase perturbation interface and the shell phase perturbation interface are both encapsulated by thin films.
In another specific embodiment, the device for preparing uniform double emulsion droplets at high flux further comprises a first injection pump, wherein the first injection pump is in communication connection with the inlet end of the nuclear phase liquid channel and is used for injecting nuclear phase liquid into the nuclear phase liquid channel;
the device for preparing the uniform double emulsion drops in high flux further comprises a second injection pump, wherein the second injection pump is communicated and connected with the inlet end of the shell phase liquid channel and is used for injecting shell phase liquid into the shell phase liquid channel;
the device for preparing the uniform double emulsion drops in high flux further comprises a third injection pump, wherein the third injection pump is in conduction connection with the driving phase inlet and is used for injecting the driving phase liquid into the cavity, or
The device for preparing the uniform double emulsion drops at high flux also comprises a power pump and a buffer;
the power pump is in conductive connection with the buffer, and the buffer is in conductive connection with the driving phase inlet;
the power pump is used for conveying the driving phase liquid into the buffer, and the buffer is used for buffering the driving phase liquid and conveying the driving phase liquid into the cavity.
In another specific embodiment, the high throughput apparatus for preparing uniform double emulsion droplets further comprises a reservoir;
the liquid storage tank is used for storing the driving phase liquid;
the power pump is a peristaltic pump, and the buffer is a buffer bottle.
In another specific embodiment, the device for preparing uniform double emulsion drops by high flux further comprises an image acquisition module,
the image acquisition module is used for acquiring image signals of double emulsion drops dripped from the discharge hole;
and/or
The device for preparing uniform double emulsion drops in high flux also comprises a drop collection module,
the liquid drop collecting module is arranged at the bottom end of the base and used for collecting double emulsion drops dropping from the discharge hole.
According to the utility model discloses an each embodiment can make up as required wantonly, and the embodiment that obtains after these combinations is also in the utility model discloses the scope is the utility model discloses a part of the concrete implementation mode.
Without being limited to any theory, as can be seen from the above disclosure, the utility model discloses a device for preparing even double emulsion drops with high flux, when using, the drive phase liquid is input to the cavity to the first time, and form stable drive phase flow field, then, let in nuclear phase liquid and shell phase liquid to nuclear phase liquid channel and shell phase liquid channel respectively, and nuclear phase disturbance is input for nuclear phase disturbance interface to the nuclear phase actuating unit, realize the broken control of nuclear phase liquid efflux, shell phase actuating unit inputs shell phase disturbance for shell phase disturbance interface, realize the broken control of shell phase liquid efflux, nuclear phase liquid is discharged from the exit end of inner capillary structure, through shell phase liquid parcel, discharge from the exit end of outer capillary structure, drive phase liquid parcel is in the outer end of shell phase liquid, and discharge from the discharge hole, form double emulsion drops. The utility model discloses a nuclear phase actuating unit and shell phase actuating unit are respectively to nuclear phase liquid and shell phase liquid input disturbance, realize the control to the size of double emulsion drop, when having realized the double emulsion drop of high flux production, have guaranteed that the size of double emulsion drop is even.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without any novelty.
Fig. 1 is a schematic structural diagram of an apparatus for preparing uniform double emulsion droplets at high flux according to the present invention;
FIG. 2 is a schematic view of the enlarged partial structure of FIG. 1 when the inner capillary tube is lower than the outer capillary tube;
FIG. 3 is an enlarged partial schematic view of FIG. 1 with the inner capillary tube higher than the outer capillary tube;
fig. 4 is a typical droplet micrograph provided by the present invention;
FIG. 5 is a graph of particle size versus frequency provided by the present invention;
FIG. 6 is a schematic diagram of an apparatus for high throughput preparation of uniform single emulsion droplets provided by the present invention;
fig. 7 is a schematic structural diagram of the droplet collection module provided by the present invention.
Wherein, in fig. 1-7:
the device comprises a base 1, a cavity 2, an inner capillary structure 3, an outer capillary structure 4, a nuclear phase actuating unit 5, a shell phase actuating unit 6, a nuclear phase liquid channel 101, a nuclear phase perturbation interface 102, a shell phase liquid channel 103, a shell phase perturbation interface 104, a driving phase inlet 201, a discharge hole 202, a nuclear phase substrate 7, a nuclear phase support column 8, a shell phase substrate 9, a shell phase support column 10, a first seal ring 11, a second seal ring 12, a first injection pump 13, a second injection pump 14, a third injection pump 15, a nuclear phase signal generator 501, a nuclear phase power amplifier 502, a shell phase signal generator 601 and a shell phase power amplifier 602.
Detailed Description
In order to make the technical solution of the present invention better understood by those skilled in the art, the present invention will be further described in detail with reference to fig. 1 to 7 and the detailed description.
As shown in fig. 1-3, the utility model discloses a device for preparing even double emulsion drops with high flux, wherein, the device for preparing even double emulsion drops with high flux includes base 1, cavity 2, interior capillary structure 3, outer capillary structure 4, nuclear phase actuating unit 5 and shell phase actuating unit 6.
The nuclear phase liquid channel 101 is formed in the base 1, the inlet end of the nuclear phase liquid channel 101 is used for inputting nuclear phase liquid, the inlet end of the inner capillary structure 3 is in conduction connection with the outlet end of the nuclear phase liquid channel 101, specifically, the inner capillary structure 3 and the base 1 can be integrally formed and connected, and the connection strength and the sealing performance of the inner capillary structure 3 and the base 1 are improved. It should be noted that the inner capillary structure 3 and the base 1 may be detachably connected.
The base 1 is provided with a nuclear phase disturbance interface 102 communicated with the nuclear phase liquid channel 101, the nuclear phase disturbance interface 102 is packaged, and the nuclear phase actuating unit 5 inputs nuclear phase disturbance through the packaged nuclear phase disturbance interface 102. Specifically, the nuclear phase perturbation interface 102 is encapsulated by a thin film so as to input nuclear phase perturbation to the nuclear phase perturbation interface 102.
Shell phase liquid channel 103 has still been seted up on base 1, shell phase liquid channel 103's entry end is used for the input of shell phase liquid, outer capillary structure 4's entry end and shell phase liquid channel 103's exit end turn-on connection, outer capillary structure 4 encircles interior capillary structure 3 and sets up, specifically, the top of outer capillary structure 4 and the bottom sealing connection of base 1, outer capillary structure 4 cover is established outside interior capillary structure 3, and interior capillary structure 3 sets up with outer capillary structure 4 is concentric.
The draw-in groove is seted up on the top of outer capillary 4, and first sealing washer 11 is arranged in the draw-in groove, and the bottom butt of top and base 1 to sealed outer capillary 4 and base 1.
The base 1 is provided with a shell phase disturbance interface 104 communicated with the shell phase liquid channel 103, the shell phase disturbance interface 104 is packaged, and the shell phase actuating unit 6 inputs shell phase disturbance through the packaged shell phase disturbance interface 104. Specifically, the shell phase interface is encapsulated by a thin film so as to input shell phase disturbances to the shell phase interface.
The cavity 2 is hermetically arranged at the bottom end of the base 1, and the outer capillary structure 4 is arranged in the cavity 2. Specifically, the holding tank has been seted up on the top of cavity 2, and in the holding tank was arranged in to second sealing washer 12, and the bottom butt of the top of second sealing washer 12 and base 1 to the realization is to cavity 2 and base 1's sealing.
The cavity 2 is provided with a driving phase inlet 201, the driving phase inlet 201 is used for inputting driving phase liquid into the cavity 2, and the shell phase liquid is insoluble with the driving phase liquid and the core phase liquid respectively.
The bottom end of the cavity 2 is provided with a discharge hole 202 which is concentric with the outlet end of the outer capillary structure 4.
The utility model discloses a device of even double emulsion liquid drop is prepared to high flux, during the use, the drive phase liquid is input to cavity 2 earlier, and form the stable drive phase flow field, then, let in nuclear phase liquid and shell phase liquid in nuclear phase liquid channel 101 and the shell phase liquid channel 103 respectively, and nuclear phase actuating unit 5 gives nuclear phase disturbance interface 102 input nuclear phase disturbance, realize the broken control to nuclear phase liquid efflux, shell phase actuating unit 6 gives shell phase disturbance interface 104 input shell phase disturbance, the broken control to shell phase liquid efflux is realized, nuclear phase liquid is discharged from the exit end of interior capillary structure 3, through shell phase liquid parcel, from the exit end of outer capillary structure 4 discharges, drive phase liquid parcel is in the outer end of shell phase liquid, and discharge from discharge hole 202, form double emulsion liquid drop. The utility model discloses a nuclear phase actuating unit 5 and shell phase actuating unit 6 are respectively to nuclear phase liquid and shell phase liquid input disturbance, realize the control to the size of double emulsion drop, when having realized the double emulsion drop of high flux production, have guaranteed that the size of double emulsion drop is even.
In some of these embodiments, the present invention discloses that the outlet end of the inner capillary structure 3 is located above or below the outlet end of the outer capillary structure 4. As shown in fig. 2 and 3. Preferably, the outlet end of the outer capillary is slightly lower than the outlet end of the inner capillary.
In some of these examples, the diameter D ═ (6Q/pi f) of the double emulsion droplets to be prepared1/3，Q＝Qo+QiWherein Q is the sum of the flow rates of the shell phase liquid and the core phase liquid, QoIs shell phase flow, QiShell phase flow, and f is the excitation frequency.
It should be noted that the disturbance may be applied to any of the shell phase and the shell phase, and may of course be applied simultaneously. The initial perturbation may be an axial perturbation, i.e. a periodic modulation of the flow velocity of the jet by externally coupled energy (mechanical, electric, magnetic, etc.).
The excitation frequency of the initial disturbance is set to be optimal near the natural breaking frequency of the jet flow, the natural breaking frequency can be changed by changing the structural parameters and the fluid properties, so that the interval of the disturbance applying frequency is adjusted, and when the external disturbance can lead the jet flow to break, the volume of the generated liquid drops is completely controlled by the shell phase flow QoNuclear phase flow rate QiAnd excitationThe frequency f is controlled together and a typical drop microscope is shown in figure 4.
The inner core of the double emulsion drop to be prepared can be independently controlled, and the diameter d of the inner core is (6Q)i/πf)1/3Wherein Q isiShell phase flow, and f is the excitation frequency.
In preparing double emulsion droplets, double emulsion droplets can be prepared at high throughput. Typically, the single flux for the shell phase liquid channel 103 and the core phase liquid channel 101 can be selected between 1ml/h and 1000ml/h, as shown in FIG. 5.
In some of these embodiments, the utility model discloses a device of even double emulsion drop is prepared to high flux still includes nuclear phase base plate 7 and nuclear phase support column 8, and nuclear phase support column 8 one end is installed on base 1, and nuclear phase base plate 7 is installed on the other end of nuclear phase support column 8, and nuclear phase actuating unit 5 is installed on nuclear phase base plate 7, and the actuating end of nuclear phase actuating unit 5 inputs the nuclear phase disturbance to nuclear phase disturbance interface 102. Specifically, the nuclear phase support column 8 is welded to the base 1, and may be detachably connected to the base 1 by a screw or the like. The nuclear phase substrate 7 can be directly welded on the nuclear phase support column 8, and can also be detachably connected on the nuclear phase support column 8 through screws and the like.
Further, the utility model discloses a device of even double emulsion drop is prepared to high flux still includes shell phase base plate 9 and shell phase support column 10, and shell phase support column 10 one end is installed on base 1, and shell phase base plate 9 is installed on the other end of shell phase support column 10, and shell phase actuating unit 6 is installed on shell phase base plate 9, and the actuating end of shell phase actuating unit 6 inputs shell phase disturbance to shell phase disturbance interface 104. Specifically, the shell phase support column 10 is welded to the base 1, and may be detachably attached to the base 1 by a screw or the like. The shell phase substrate 9 may be directly welded to the shell phase support posts 10, or may be detachably attached to the shell phase support posts 10 by screws or the like.
In some of these embodiments, the utility model discloses a nuclear phase actuating unit 5 includes nuclear phase signal generator 501, nuclear phase power amplifier 502 and nuclear phase actuator, and nuclear phase signal generator 501 and nuclear phase power amplifier 502 signal connection, nuclear phase power amplifier 502 and nuclear phase actuator signal connection, and the nuclear phase disturbing signal that nuclear phase signal generator 501 sent is through nuclear phase power amplifier 502 after the amplification, exports nuclear phase disturbance interface 102 department through the nuclear phase actuator.
The disturbance signal output by the nuclear phase signal generator 501 may be a sine signal, a sawtooth signal, a rectangular wave signal, or the like, preferably a sine modulation; it is also possible to combine multiple modulations, preferably with the same period, although other combinations of signals are possible.
The nuclear phase actuator may take many forms, for example, a piezoelectric ceramic, an electromagnetic oscillator, or the like, which may provide a unit of vibration.
Further, the utility model discloses a shell phase actuating unit 6 includes shell phase signal generator 601, shell phase power amplifier 602 and shell phase actuator, and shell phase signal generator 601 and shell phase power amplifier 602 signal connection, shell phase power amplifier 602 and shell phase actuator signal connection, and the shell phase disturbing signal that shell phase signal generator 601 sent is through shell phase power amplifier 602 after the amplification, exports shell phase disturbing interface 104 department through shell phase actuator.
The disturbing signal output by the shell phase signal generator 601 may be a sinusoidal signal, a sawtooth wave signal, a rectangular wave signal, etc., preferably a sinusoidal modulation; it is also possible to combine multiple modulations, preferably with the same period, although other combinations of signals are possible.
The shell phase actuator may take various forms, for example, a piezoelectric ceramic, an electromagnetic oscillator, or the like, which may provide a unit that vibrates.
In some other embodiments, the utility model discloses a device of even double emulsion drop is prepared to high flux still includes power pump and buffer, and power pump and buffer turn-on connection, buffer and drive looks entry 201 turn-on connection, and in the power pump was used for carrying the buffer with drive looks liquid, the buffer was used for buffering drive looks liquid to carry cavity 2 with drive looks liquid. The pulse flow of the power pump is attenuated after passing through the buffer, and the single emulsion droplet particle size influence parameter is not influenced by the flow of the driving phase liquid within a certain range. Specifically, the utility model discloses a power pump is the peristaltic pump, and the buffer is the cushion flask. The power pump is not limited to the peristaltic pump described above, and may be another type of pump. The buffer bottle is not limited to the bottle structure, but may be other structures.
Note that, each phase liquid may be directly injected by a syringe pump, and a syringe pump for injecting a nuclear phase liquid may be used as the first syringe pump 13, a syringe pump for injecting a shell phase liquid may be used as the second syringe pump 14, and a syringe pump for injecting a driving phase liquid may be used as the third syringe pump 15, as shown in fig. 6.
Further, the device for preparing uniform double emulsion drops in high flux also comprises a liquid storage tank, and the liquid storage tank is used for driving the storage of phase liquid. Under the condition of needing a large amount of driving phase liquid, only the driving phase liquid is needed to be added into the liquid storage tank, and the method has important practical value when single emulsion drops are continuously prepared in a large scale.
In some embodiments, the apparatus for high-throughput preparation of uniform double emulsion droplets further comprises an image acquisition module for acquiring image signals of double emulsion droplets dripped from the discharge hole 202. The image collector is positioned below the cavity 2 and used for collecting image information and transmitting the collected information to the controller. The image collector is a camera or a video camera and the like, and the controller is a computer and the like.
In order to facilitate the signal of gathering the single emulsion drop, the utility model discloses a device of even two emulsion drops of high flux preparation still includes the strobe light, and the strobe light setting is located one side of single emulsion drip in the below of cavity 2.
Further, the utility model discloses a device of even two emulsion drops of high flux preparation still includes the liquid drop collection module, as shown in fig. 7, and the bottom of base 1 is arranged in to the liquid drop collection module for collect the two emulsion drops that discharge port 202 dripped. Specifically, the droplet collection module comprises a container, wherein a collection liquid is contained in the container, and the collection liquid and the driving phase liquid are immiscible.
The utility model discloses a shell phase actuating unit 6 and nuclear phase actuating unit 5 initiative control fluidic initial disturbance (including frequency and amplitude), the fluid of flowing from the upper reaches is led by plus disturbance, and the broken frequency of efflux can be controlled in the disturbance. The utility model discloses can the fluidic crushing process of accurate control, can control the particle diameter of liquid drop and fluidic length, in addition, through adjusting the frequency interval of applying the disturbance of natural frequency of breakage adjustment, use more extensively. The utility model discloses can also be applicable to the fluid of different attributes (viscosity, interfacial tension), accord with the condition to different fluid among the various practical application very much.
The utility model discloses device of even two emulsion drops of well high flux preparation, owing to adopt shell phase actuating unit 6 and the initial disturbance of 5 control of nuclear phase actuating unit, can realize the accurate control of efflux crushing process, especially control fluidic broken frequency, and the wide application is in various liquid drop micro-fluidic technologies moreover, and can effectively overcome current micro-fluidic for preparing even liquid drop and rely on the shortcoming that the flux can not be compromise to the drip mode, is particularly suitable for being used for the scene that needs utilize the little liquid drop of efflux mode and a large amount of preparation.
In the present invention, "first", "second", etc. are all distinguished in description, and have no other special meaning.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (8)
1. A device for preparing uniform double emulsion drops in high flux is characterized by comprising a base, a cavity, an inner capillary structure, an outer capillary structure, a nuclear phase actuating unit and a shell phase actuating unit;
the base is provided with a nuclear phase liquid channel, the inlet end of the nuclear phase liquid channel is used for inputting nuclear phase liquid, the inlet end of the inner capillary structure is in conduction connection with the outlet end of the nuclear phase liquid channel, the base is provided with a nuclear phase disturbance interface which is in conduction with the nuclear phase liquid channel, the nuclear phase disturbance interface is packaged, and the nuclear phase actuating unit inputs nuclear phase disturbance through the packaged nuclear phase disturbance interface;
the base is further provided with a shell phase liquid channel, the inlet end of the shell phase liquid channel is used for inputting shell phase liquid, the inlet end of the outer capillary structure is communicated with the outlet end of the shell phase liquid channel, the outer capillary structure is arranged around the inner capillary structure, the inner capillary structure and the outer capillary structure are concentrically arranged, the base is provided with a shell phase disturbance interface communicated with the shell phase liquid channel, the shell phase disturbance interface is packaged, and the shell phase actuating unit inputs shell phase disturbance through the packaged shell phase disturbance interface;
the cavity is hermetically arranged at the bottom end of the base, and the outer capillary structure is arranged in the cavity;
the cavity is provided with a driving phase inlet, the driving phase inlet is used for inputting driving phase liquid into the cavity, and the shell phase liquid is immiscible with the driving phase liquid and the nuclear phase liquid respectively;
the bottom end of the cavity is provided with a discharge hole which is concentric with the outlet end of the outer capillary structure.
2. High throughput uniform double emulsion droplet preparation apparatus according to claim 1, wherein the outlet end of said inner capillary structure is located above or below the outlet end of said outer capillary structure;
and/or
Diameter D ═ (6Q/. pi.f) of the double emulsion droplets to be prepared1/3，
Q＝Qo+Qi，
Wherein Q is the sum of the flow rates of the shell phase liquid and the core phase liquid,
Qothe flow rate of the shell phase is the flow rate of the shell phase,
Qithe flow rate of the shell phase is the flow rate of the shell phase,
f is the excitation frequency;
and/or
The above-mentionedThe diameter d of the core of the double emulsion droplets to be prepared is (6Q)i/πf)1/3，
Wherein Q isiThe flow rate of the shell phase is the flow rate of the shell phase,
f is the excitation frequency.
3. The device for high throughput preparation of uniform double emulsion droplets of claim 1, further comprising a nucleation phase substrate and a nucleation phase support column,
one end of the nuclear phase supporting column is installed on the base, the nuclear phase substrate is installed on the other end of the nuclear phase supporting column, the nuclear phase actuating unit is installed on the nuclear phase substrate, and the actuating end of the nuclear phase actuating unit inputs nuclear phase disturbance to the nuclear phase disturbance interface;
and/or
The device for preparing the uniform double emulsion drops in high flux also comprises a shell phase substrate and a shell phase supporting column,
one end of the shell phase supporting column is installed on the base, the shell phase substrate is installed on the other end of the shell phase supporting column, the shell phase actuating unit is installed on the shell phase substrate, and the actuating end of the shell phase actuating unit inputs shell phase disturbance to the shell phase disturbance interface.
4. High throughput uniform double emulsion droplets preparation device according to claim 3 wherein said nuclear phase actuation unit comprises a nuclear phase signal generator, a nuclear phase power amplifier and a nuclear phase actuator,
the nuclear phase signal generator is in signal connection with the nuclear phase power amplifier, the nuclear phase power amplifier is in signal connection with the nuclear phase actuator,
a nuclear phase disturbance signal sent by the nuclear phase signal generator is amplified by the nuclear phase power amplifier and then is output to the nuclear phase disturbance interface through the nuclear phase actuator;
and/or
The shell phase actuating unit comprises a shell phase signal generator, a shell phase power amplifier and a shell phase actuator,
the shell-phase signal generator is in signal connection with the shell-phase power amplifier, the shell-phase power amplifier is in signal connection with the shell-phase actuator,
and after being amplified by the shell phase power amplifier, the shell phase disturbance signal sent by the shell phase signal generator is output to the shell phase disturbance interface through the shell phase actuator.
5. The device for high-throughput preparation of uniform double emulsion droplets according to claim 4, wherein the nuclear phase perturbation interface and the shell phase perturbation interface are both encapsulated by thin films.
6. The device for high-throughput preparation of uniform double emulsion droplets according to claim 1, further comprising a first syringe pump, wherein the first syringe pump is in fluid connection with the inlet end of the nuclear phase liquid channel and is used for injecting nuclear phase liquid into the nuclear phase liquid channel;
the device for preparing the uniform double emulsion drops in high flux further comprises a second injection pump, wherein the second injection pump is communicated and connected with the inlet end of the shell phase liquid channel and is used for injecting shell phase liquid into the shell phase liquid channel;
the device for preparing the uniform double emulsion drops in high flux also comprises a third injection pump which is communicated and connected with the driving phase inlet and is used for injecting the driving phase liquid into the cavity,
or
The device for preparing uniform double emulsion drops at high flux also comprises a power pump and a buffer,
the power pump is in conductive connection with the buffer, the buffer is in conductive connection with the driving phase inlet,
the power pump is used for conveying the driving phase liquid into the buffer, and the buffer is used for buffering the driving phase liquid and conveying the driving phase liquid into the cavity.
7. The high throughput uniform double emulsion droplet generator of claim 6, further comprising a reservoir;
the liquid storage tank is used for storing the driving phase liquid;
the power pump is a peristaltic pump, and the buffer is a buffer bottle.
8. High throughput device for preparing uniform double emulsion droplets according to any one of claims 1 to 7, further comprising an image acquisition module,
the image acquisition module is used for acquiring image signals of double emulsion drops dripped from the discharge hole;
and/or
The device for preparing uniform double emulsion drops in high flux also comprises a drop collection module,
the liquid drop collecting module is arranged at the bottom end of the base and used for collecting double emulsion drops dropping from the discharge hole.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111821913A (en) * | 2020-08-19 | 2020-10-27 | 中国科学技术大学 | Device and method for preparing uniform double emulsion drops in high flux |
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