CN107029640B - Micro-droplet active preparation device and method based on liquid-driven flow focusing jet disturbance - Google Patents
Micro-droplet active preparation device and method based on liquid-driven flow focusing jet disturbance Download PDFInfo
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- 239000007788 liquid Substances 0.000 title claims abstract description 57
- 238000002360 preparation method Methods 0.000 title claims abstract description 33
- 238000000034 method Methods 0.000 title description 11
- 239000000523 sample Substances 0.000 claims abstract description 46
- 239000011810 insulating material Substances 0.000 claims description 4
- 230000015556 catabolic process Effects 0.000 claims description 3
- 230000002452 interceptive effect Effects 0.000 claims description 3
- 238000010008 shearing Methods 0.000 abstract description 3
- 239000012071 phase Substances 0.000 description 17
- 230000015572 biosynthetic process Effects 0.000 description 6
- 239000011258 core-shell material Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
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- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
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Abstract
The invention discloses a micro-droplet active preparation device and a micro-droplet active preparation method based on liquid drive flow focusing jet disturbance, which belong to the technical field of micro-flow control, wherein a vibrating piezoelectric cantilever beam drives a probe to interfere with an unbroken jet column, and the probe is adhered near the free end of the piezoelectric cantilever beam; the jet flow column is formed by focusing based on liquid driving flow, driving liquid flows through the round hole from the driving liquid inlet, shearing force is provided for micro-droplet phases introduced by the needle tube to form a stable cone, the micro-droplet phases further pass through the round hole to form the jet flow column, and liquid in the container flows out through the outlet. When the piezoelectric cantilever beam is disturbed, the vibration of the piezoelectric cantilever beam drives the probe to interfere the jet flow column, and the technical scheme of the invention controls the size and the generation frequency of micro liquid drops generated by the breaking of the jet flow column by controlling the driving voltage, the driving frequency or the driving waveform of the piezoelectric cantilever beam.
Description
Technical Field
The invention relates to the technical field of microfluidics, in particular to a micro-droplet active preparation device and method based on liquid drive flow focusing jet disturbance.
Background
The formation of droplets intuitively illustrates the complexity of the microfluidic process. The relatively small forces associated with surface tension create a high degree of nonlinearity during droplet formation and are susceptible to external disturbance anomalies. The formation of droplets from a continuous liquid phase requires the introduction of energy that is converted into surface energy after droplet formation. When the energy is only derived from the fluid pressure and no external energy is input, the control is passive; in contrast, during droplet generation, there is active control when external energy is input. The classical structure of passive control is: t-type and flow focusing type. Passive control of both structures is achieved primarily by varying the flow or pressure. The biggest problems with passive control are: the response time is too long, typically a few seconds or even minutes. Longer response times are mainly limited by relatively large fluid resistances. At a preset flow rate and pressure, the only way to achieve a droplet of a specific size is to adjust the liquid properties and channel shape. The active control generation of droplets is mainly divided into: thermal control, magnetic control, gas/liquid drive control, piezoelectric control, and the like. Since piezoelectric actuation has a fast response, typically up to 200 μs, there is increasing interest in the research of piezo-active actuation to produce micro-droplets, and at present, the introduction of piezoelectric perturbation is mainly directed to microfluidic chips, and the volume or frequency of micro-droplet formation is controlled by introducing vibrations of a piezoelectric wafer, piezoelectric bimorph or piezoelectric stack, for example, on an inlet pipe, before jet formation. Compared with the preparation of micro-droplets of a microfluidic chip, the preparation of micro-droplets by liquid-driven flow focusing has many advantages, such as low cost, high encapsulation efficiency, high yield and the like. Micro-droplets generated by two-dimensional planar microfluidic chip technology often deform in contact with the cavity walls. At present, the flow focusing based on liquid flooding is usually realized by changing the flow to change the size and the generation frequency of the generated micro-droplets, but the change range is limited, the flow is too large and too small, the taper of stable process is not realized, the generated micro-droplets are poor in size uniformity and often accompanied with the occurrence of satellite droplets, so that the influence on external disturbance is small, and the wettability problem is further improved, so that the problem to be solved is to actively prepare the micro-droplets.
Disclosure of Invention
Based on the problems existing in the prior art, the invention aims to provide a micro-droplet active preparation device and method based on liquid drive flow focusing jet disturbance, which are used for preparing micro-droplets through active control.
The invention aims at realizing the following technical scheme:
the embodiment of the invention provides a micro-droplet active preparation device based on liquid drive flow focusing jet disturbance, which comprises the following components:
a piezoelectric device and a probe; wherein,,
the piezoelectric device is arranged above the jet flow column container, the probe is arranged on the piezoelectric device, the front end of the probe stretches into liquid in the jet flow column container and is positioned above the jet flow column in the jet flow column container, and the piezoelectric device can vibrate and drive the probe to vibrate to interfere with uncrushed jet flow column micro drops.
The embodiment of the invention also provides a micro-droplet active preparation method based on the disturbance of the liquid-driven flow focusing jet flow, which adopts the active preparation device provided by the invention and comprises the following steps:
the size and the generation frequency of micro liquid drops generated by the probe interfering with the breaking of the jet flow column are controlled by controlling the driving voltage, the driving frequency or the driving waveform of the piezoelectric device of the active preparation device, wherein the driving voltage is smaller than the breakdown voltage of the piezoelectric device, the driving frequency is the vibration frequency of the piezoelectric device and the probe in the liquid, and the driving waveform is any one of sine waves, square waves or saw-tooth waves.
According to the technical scheme provided by the invention, the micro-droplet active preparation device and method based on liquid-driven flow focusing jet disturbance provided by the embodiment of the invention have the beneficial effects that:
the disturbance process can be accurately controlled, and micro-droplets with required size and generation frequency can be conveniently prepared through active control.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are needed in the description of the embodiments will be briefly described below, it being obvious that the drawings in the following description are only some embodiments of the present invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of an active preparation device for micro-droplets according to an embodiment of the present invention;
FIG. 2 is a schematic structural view of a coaxial wrapped tubular body of a turbulent jet needle tube provided by an embodiment of the present invention;
FIG. 3 is a schematic view of a probe with a circular opening according to an embodiment of the present invention;
fig. 4 is a schematic structural diagram of a piezoelectric device using a piezoelectric simply supported beam according to an embodiment of the present invention;
in the figure: 1-jet column, 2-needle tube, 3-microdroplet phase inlet, 31-nuclear phase, 32-shell phase, 4-cone, 5-driving liquid inlet, 6-round hole, 7-probe, 71-round opening, 8-piezoelectric cantilever beam, 9-outlet, 10-container body, 11-piezoelectric simple beam.
Detailed Description
The following description of the embodiments of the present invention will clearly and fully describe the technical solutions of the embodiments of the present invention in conjunction with the specific contents of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to fall within the scope of the invention.
As shown in fig. 1, an active preparation device for micro-droplets based on disturbance of liquid-driven flow focusing jet flow according to an embodiment of the present invention can actively control preparation of micro-droplets, including:
a piezoelectric device and a probe; wherein,,
the piezoelectric device is arranged above the jet flow column container, the probe is arranged on the piezoelectric device, the front end of the probe stretches into liquid in the jet flow column container and is positioned above the jet flow column in the jet flow column container, and the piezoelectric device can vibrate and drive the probe to vibrate to interfere with uncrushed jet flow column micro drops. In the container with the structure, the jet flow column is formed by focusing based on liquid driving flow, driving liquid flows through the round hole from the driving liquid inlet, shearing force is provided for micro-droplet phases introduced by the needle tube to form a stable cone shape, the micro-droplet phases further pass through the round hole to form the jet flow column, and liquid in the container flows out through the outlet.
Referring to fig. 1, in the preparation apparatus, the piezoelectric device adopts a piezoelectric cantilever beam with one end fixed and the other end being a free end, the rear end of the probe is connected to the free end of the piezoelectric cantilever beam, and the specific probe is adhered near the free end of the piezoelectric cantilever beam.
Referring to fig. 4, in the above-mentioned preparation apparatus, the piezoelectric device is a piezoelectric simply supported beam with two fixed ends, and the rear end of the probe is connected to the middle part of the piezoelectric simply supported beam, which may specifically be disposed at the midpoint of the piezoelectric simply supported beam.
In the preparation device, the probe is made of an insulating material;
or the probe is made of insulating materials, the front end of the probe is provided with a circular opening (see figure 3) for the jet flow column to pass through, the jet flow column and the circular opening of the probe are concentric in the initial state, and the piezoelectric device drives the probe to disturb the jet flow column when vibrating.
In the above-mentioned preparation facilities, the jet column container includes:
the container body is provided with a driving liquid inlet at the upper end of the container body;
a droplet phase inlet arranged on the container body below the driving liquid inlet, a needle tube is arranged in the droplet phase inlet, the front end outlet of the needle tube corresponds to a round hole correspondingly arranged on the container body, and the needle tube can output liquid focused in the container body based on liquid driving flow to form a jet flow column;
and an outlet is correspondingly arranged on the container body behind the jet flow column.
In the preparation device, the needle tube is a single tube body or a coaxial wrapped tube body;
the container body adopts a transparent shell.
The embodiment of the invention provides a micro-droplet active preparation method based on liquid drive flow focusing jet disturbance, which adopts the active preparation device provided by the invention and comprises the following steps:
the size and the generation frequency of micro liquid drops generated by the probe interfering with the breaking of the jet flow column are controlled by controlling the driving voltage, the driving frequency or the driving waveform of the piezoelectric device of the active preparation device, wherein the driving voltage is smaller than the breakdown voltage of the piezoelectric device, the driving frequency is the vibration frequency of the piezoelectric device and the probe in the liquid, and the driving waveform is any one of sine waves, square waves or saw-tooth waves.
In the method, the micro-droplet phase can be formed by a core phase and a shell phase, the core phase can also be of a multi-core structure, further a jet column with a core-shell structure is formed, and the micro-droplet with the core-shell structure is formed through the disturbance of a piezoelectric device;
the preparation device provided by the invention has the advantages that the probe positioned right above the jet flow column is driven by the vibrating piezoelectric cantilever beam to interfere the uncrushed jet flow column to form micro-droplets, so that micro-droplets with uniform size and generation frequency required by preparation are actively controlled, the problems that the change amplitude of micro-droplets formed by controlling flow is limited, the flow is too large and too small, the taper shape with stable process is not easy to implement, the response time is long, usually a few seconds, the size uniformity of the generated micro-droplets is poor, satellite droplets are often accompanied, and the like are avoided.
Embodiments of the present invention are described in detail below.
As shown in fig. 1, the embodiment of the invention provides a micro-droplet active preparation device based on liquid-driven flow focusing jet disturbance, which mainly uses a piezoelectric cantilever beam 8 as a piezoelectric device to drive a probe 7 to interfere an uncrushed jet column 1, wherein the probe 7 on the piezoelectric cantilever beam 8 is positioned right above the jet column 1, and the probe 7 is adhered near the free end of the piezoelectric cantilever beam 8; the jet flow column 1 is formed by focusing based on liquid driving flow, driving liquid flows through the round hole 6 from the driving liquid inlet 5, a stable cone 4 is formed by providing shearing force for the micro-droplet phase 3 introduced by the needle tube 2, the micro-droplet phase 3 further passes through the round hole 6 to form the jet flow column 1, and liquid in the container 10 flows out through the outlet 9.
Only the probe 7 is stretched into the liquid, so that the insulation problem of the piezoelectric cantilever beam 8 is solved, and the liquid resistance is reduced.
When the electric cantilever beam 8 is not pressurized, the jet column 1 is prolonged under the liquid environment and is crushed due to surface tension, the size of the crushed liquid drops can be controlled only according to the flow, the response time is long, usually a few seconds, and the generated liquid drops are uneven in size and often occur with satellite liquid drops; when the piezoelectric cantilever beam 8 is pressurized to disturb, the vibration of the piezoelectric cantilever beam 8 drives the probe 7 to disturb the jet flow column 1, and the micro-droplet size and the generation frequency generated by the breaking of the jet flow column 1 are controlled by controlling the driving voltage, the driving frequency or the driving waveform of the piezoelectric cantilever beam 8.
As shown in fig. 2, the needle tube 2 may be two coaxial needle tubes, that is, the micro-droplet phase 3 may be formed by a core phase 31 and a shell phase 32, and the core phase 3-1 may be of a multi-core structure, so as to form a jet column with a core-shell structure, and the micro-droplet with the core-shell structure is formed by the disturbance of a piezoelectric cantilever beam.
As shown in fig. 3, the probe 7 may also have a circular opening 71, and in the initial state, the jet column 1 is concentric with the circular opening 71, and when the piezoelectric cantilever beam 8 vibrates, the probe 7 is driven to disturb the jet column 1.
As shown in fig. 4, the piezoelectric cantilever beam 8 as the piezoelectric device may be replaced by a piezoelectric simple beam 11, and the probe 7 is adhered to the middle point of the piezoelectric simple beam 11, so that the up-down swing of the probe 7 is purer.
The invention aims at the liquid-driven flow focusing device, introduces the energy of piezoelectric vibration after the jet flow column is formed, can intuitively and clearly observe the disturbance process, and prepares micro-droplets with required size and generation frequency by active control.
The foregoing is only a preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions easily contemplated by those skilled in the art within the scope of the present invention should be included in the scope of the present invention. Therefore, the protection scope of the present invention should be subject to the protection scope of the claims.
Claims (4)
1. The micro-droplet active preparation device based on liquid-driven flow focusing jet disturbance is characterized by comprising:
a piezoelectric device and a probe; wherein,,
the piezoelectric device is arranged above the jet flow column container, the probe is arranged on the piezoelectric device, the front end of the probe stretches into liquid in the jet flow column container and is positioned above the jet flow column in the jet flow column container, and the piezoelectric device can vibrate to drive the probe to vibrate so as to interfere with uncrushed jet flow column micro drops;
the piezoelectric device adopts a piezoelectric cantilever beam with one fixed end and the other free end, the rear end of the probe is connected with the free end of the piezoelectric cantilever beam, or the piezoelectric device adopts a piezoelectric simply supported beam with two fixed ends, and the rear end of the probe is connected with the middle part of the piezoelectric simply supported beam;
the jet column container comprises: the container body is provided with a container body,
a driving liquid inlet arranged at the upper end of the container body;
a droplet phase inlet arranged on the container body below the driving liquid inlet, a needle tube is arranged in the droplet phase inlet, the front end outlet of the needle tube corresponds to a round hole correspondingly arranged on the container body, and the needle tube can output liquid focused in the container body based on liquid driving flow to form a jet flow column;
and an outlet is correspondingly arranged on the container body behind the jet flow column.
2. The micro-droplet active preparation device based on liquid-driven flow focusing jet disturbance according to claim 1, wherein,
the probe is made of an insulating material;
alternatively, the probe is made of an insulating material, and a circular opening for the jet column to pass through is formed in the front end of the probe.
3. The active preparation device of micro-droplets based on liquid-driven flow focusing jet disturbance according to claim 1, wherein the needle tube is a single tube body or a coaxial tube body;
the container body adopts a transparent shell.
4. An active preparation method of micro-droplets based on liquid-driven flow focusing jet disturbance is characterized by adopting the active preparation device as claimed in any one of claims 1 to 3, comprising the following steps:
the size and the generation frequency of micro liquid drops generated by the probe interfering with the breaking of the jet flow column are controlled by controlling the driving voltage, the driving frequency or the driving waveform of the piezoelectric device of the active preparation device, wherein the driving voltage is smaller than the breakdown voltage of the piezoelectric device, the driving frequency is the vibration frequency of the piezoelectric device and the probe in the liquid, and the driving waveform is any one of sine waves, square waves or saw-tooth waves.
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| CN110227378A (en) * | 2019-05-27 | 2019-09-13 | 肇庆市华师大光电产业研究院 | A kind of preparation method of size uniformity and the controllable aqueous two-phase microlayer model of size |
| CN111821913A (en) * | 2020-08-19 | 2020-10-27 | 中国科学技术大学 | Device and method for preparing uniform double emulsion drops in high flux |
| CN111841439A (en) * | 2020-08-19 | 2020-10-30 | 中国科学技术大学 | Device and method for preparing uniform single emulsion drops in high flux |
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