CN212255362U - Liquid sample detection device - Google Patents

Abstract

The utility model provides a liquid sample detection device, which comprises a mixing cavity, a detection cavity and a sample adding unit, wherein the mixing cavity, the detection cavity and the sample adding unit are arranged in a device main body, detection liquid is filled in the mixing cavity, a sample can be added in the mixing cavity, and after the sample is added, the detection liquid and the sample are mixed to obtain mixed liquid; a test element is arranged in the detection cavity and used for detecting whether the mixed solution contains the analyte or not; the sample adding unit is internally provided with a communicating cavity. The utility model provides a liquid sample detection device can be fine be applied to the occult blood detection of liquid excrement and urine, the hybrid chamber is located the below of the liquid entry that detects the chamber, and the detection liquid in the hybrid chamber can't flow in under the effect of gravity and detect the intracavity, and the detection liquid that can fundamentally hybrid chamber probably flows in under the effect of gravity and detects the intracavity and lead to the condemned technical problem of device.

Description

Liquid sample detection device

Technical Field

The utility model belongs to the technical field of the medical instrument technique and specifically relates to a sample detection device that can be used for detecting liquid sample.

Background

In the field of medical biology, the analysis and detection of samples is a whole process, and the analysis and detection of samples is the basis of numerous tests and treatments. Some liquid samples need to be mixed with detection liquid for reaction in advance during detection, the mixing process of the samples and the detection liquid relates to the problem of sample quantification, the operation is more complicated, and in addition, for some samples with pollution properties, detection personnel have safety and sanitation requirements and are inconvenient to directly contact.

Specifically, feces are generally solid, when people suffer from diseases such as gastroenteritis, the feces can be liquid, when feces detection is carried out, occult blood in the liquid feces can be detected, the occult blood of the feces has great significance for early screening of malignant tumors (such as gastric cancer, colorectal cancer, polyps and adenomas) in the digestive tract, the occult blood detection of the feces is one of important technologies for early diagnosis of colorectal cancer and screening of people, and patients with positive occult blood of the feces are subjected to colonoscopy, so that the tumor detection rate can be improved by 4-6 times, and the method is the best method for screening high risk groups with colorectal tumors at present. A plurality of large-scale cohort studies prove that the colorectal cancer incidence and mortality of people can be obviously reduced by detecting fecal occult blood every year. Fecal occult blood detection has been recommended as the most important colorectal cancer screening technology by a plurality of authoritative organizations such as American cancer society, early colorectal cancer treatment projects of the national ministry of health of China, and digestive disease division of the Chinese medical society.

In the conventional fecal occult blood detection, a subject needs to take feces for inspection and then the feces are detected by professional personnel in hospitals. However, because of the high requirements for storing and transporting the collected and sent samples of the feces, people who attend physical examination in hospitals often choose to ignore or not send the feces for examination because of inconvenience. Therefore, in actual population screening and physical examination, the feces sampling and examination rate is low. In a colorectal cancer screening test in a Xuhui area and a Haerbin south sentry area, the inspection rate of excrement of community residents is less than 40%.

In fact, the colloidal gold immunity test paper on the market is very simple to detect fecal occult blood, is similar to the early pregnancy test paper, and can be completely detected by community residents at home and judge the result by the community residents. But are reluctant to look directly or touch feces due to their strong odor. Secondly, in fecal detection, it is generally required to be fully mixed with the detection solution before the detection by the immune test paper can be carried out. Again, control of stool sampling volume is difficult. Finally, the excrement is not leaked after being dissolved in the detection liquid in the detection operation, otherwise, the excrement is not suitable for household or non-specialized household detection. At present, some fecal occult blood reagent manufacturers are respectively provided with some feces sampling devices, but the feces sampling devices do not have sampling amount control devices and do not comprise detectors, and all detections are carried out under an open condition. Therefore, fecal occult blood is limited to be carried out in a professional medical institution at present, a professional generally places quantitative fecal into a container with detection liquid for dissolving when detecting, then pours the fecal liquid in the container into a small cup or a small hole, then inserts a liquid absorption test strip into the small cup or the small hole for detecting, according to the colloidal gold immunochromatography principle, a mixed liquid contacts with the test strip in the kit to run off a board, a color band appears, and according to the color depth of the color band, the fecal occult blood is judged to be negative or positive by comparing the color depth with a standard color card. The fecal occult blood can not be measured by non-professionals at present due to the defects that fecal liquid is open during detection, the frequency of direct vision of feces is high, a small cup and a small hole are easy to overturn and overflow and leak the liquid during operation, the operation is carried out by wearing gloves, and detection instruments are not dispersed into a whole set and are inconvenient to carry and transport.

A small number of instruments suitable for fecal occult blood self-testing are available on the market, and most of the instruments can only detect solid feces and cannot detect liquid feces. In addition, in their inner structure, the position that general detection chamber set up is less than the hybrid chamber, or the position that detection chamber set up is the same with the hybrid chamber height on the horizontal direction, make things convenient for the inside mixed liquid of hybrid chamber to flow into under the effect of gravity and detect the chamber in, but set up like this and also brought technical problem, if the hybrid chamber and the sealed problem that has appeared between the detection chamber, when the sample was not added to the hybrid chamber, the detection liquid in the hybrid chamber just flows into under the effect of gravity and detects the intracavity, and with the test element contact, this sample testing device has just been scrapped.

Disclosure of Invention

An object of the utility model is to provide a liquid sample detection device to solve the problem that proposes among the above-mentioned background art.

In order to achieve the above object, the technical solution adopted by the present invention is a liquid sample testing device, comprising a mixing chamber, a testing chamber and a sample adding unit, wherein the mixing chamber, the testing chamber and the sample adding unit are arranged in a device main body, a testing liquid is filled in the mixing chamber, a sample can be added in the mixing chamber, and after the sample is added, the testing liquid and the sample are mixed to obtain a mixed liquid;

a test element is arranged in the detection cavity and used for detecting whether the mixed solution contains the analyte or not;

a communicating cavity is arranged in the sample adding unit;

the sample adding unit comprises two working positions: the mixing cavity and the detection cavity are in a non-communicated state when the sample adding unit is positioned at the first working position; when the sample adding unit is positioned at the second working position, the mixing cavity is communicated with the detection cavity through the communicating cavity.

Further, the mixing chamber and the detection chamber are communicated through a passage.

Further, the channel extends into the detection chamber.

Furthermore, a sealing element is arranged on the sample adding unit;

when the sample adding unit is positioned at the first working position, the sealing element is contacted with the channel to seal the channel;

when the sample adding unit is located at the second working position, the sealing element is separated from the channel, and the channel is not sealed.

Furthermore, a first communicating hole and a second communicating hole are arranged in the inner wall of the communicating cavity.

Further, the detection cavity and the communication cavity are communicated through the first communication hole.

Further, when the sample adding unit is in the second working position, the communication cavity and the mixing cavity are communicated through the second communication hole.

Furthermore, the sample adding unit also comprises an end cover, and the end cover is detachably connected with the communicating cavity.

Further, when the end cover is separated from the communication cavity, the communication cavity is communicated with the outside; when the end cover is connected with the communicating cavity, the communicating cavity is isolated from the outside.

Furthermore, the liquid sample detection device also comprises a cover body used for covering the detection cavity, and the cover body is connected with the sample adding unit.

To sum up, the beneficial effects of the utility model are that: the utility model provides a liquid sample detection device can be used in the occult blood detection of liquid excrement and urine very well, the mixing chamber is located below the liquid inlet of the detection chamber, the detection liquid in the mixing chamber can't flow into the detection chamber under the effect of gravity, therefore fundamentally solved in the background art the detection liquid in the mixing chamber may flow into the detection chamber under the effect of gravity and lead to the technical problem that the device is scrapped; the detection personnel do not need to look directly and contact with the excrement in the detection process, and the detection result of the test strip can be directly read from the outer side of the device; the lid passes through screw-thread fit and detects the chamber lid and merge and keep inseparable, can completely cut off faecal stink, lets the testing process clean, sanitary.

Drawings

FIG. 1 is a schematic view of the overall structure of a liquid sample testing device;

FIG. 2 is an exploded view of a liquid sample testing device;

FIG. 3 is a cross-sectional view of the device body;

FIG. 4 is a sectional view showing the entire structure of the liquid sample testing device in an initial state;

FIG. 5 is a sectional view of the entire structure of the liquid sample testing device in the sample application state;

fig. 6 is a sectional view of the entire structure of the liquid sample testing device in a testing state.

Detailed Description

Embodiments of the invention will be described in further detail with reference to the drawings, it being understood that the examples are illustrative only and should not be taken as limiting the invention, and that all of the features disclosed in the examples or all of the steps in any method or process disclosed herein can be combined in any way, except for mutually exclusive features and/or steps.

The present embodiment provides a liquid sample testing device, which includes a mixing chamber 20 and a testing chamber 30 disposed in a device body 10. The mixing chamber is a chamber for mixing the sample and the detection liquid, the sample and the detection liquid are mixed and then dissolved in the detection liquid to obtain a mixed liquid, and the sample can be liquid excrement. The detection cavity is a cavity for detecting the mixed liquid, a test element is arranged in the detection cavity and used for detecting whether the mixed liquid contains the analyzed substance, and the analyzed substance can be blood. Specifically, referring to fig. 3 to 5, the detection chamber 30 includes a liquid inlet 31, when the device body 10 is in the state shown in fig. 3 to 5, which is also referred to as a device being in the upright position, the mixing chamber 20 is located below the liquid inlet 31 of the detection chamber 30, and the detection liquid in the mixing chamber 20 cannot flow into the detection chamber 30 under the action of gravity, so that the technical problem that the detection liquid in the mixing chamber may flow into the detection chamber under the action of gravity to cause device rejection in the background art is fundamentally solved.

The premise of achieving the technical effect is that the device is arranged right, but some other situations still exist in the transportation process of the detection device, and the device can be inclined and overturned. To avoid the situation that the detection liquid flows into the detection cavity due to the inclination and the overturn of the device. This liquid sample detection device still includes application of sample unit 50, and application of sample unit 50 includes two operating position: a first operating position and a second operating position. When the sample adding unit 50 is located at the first working position, the mixing chamber 20 and the detection chamber 30 are in a non-communicating state, and the first working position is a state when the device is not activated (a state when the detection device leaves a factory); when the sample adding unit 50 is located at the second working position, the mixing chamber 20 and the detection chamber 30 are in a communication state, and the second working position is a state when the device performs detection. Specifically, referring to FIGS. 4-5, the mixing chamber 20 and the detection chamber 30 communicate through a passageway 40. The sample adding unit 50 is located in the channel, a communicating cavity 51 is arranged in the sample adding unit 50, and a first communicating hole 52 and a second communicating hole 53 are arranged in the inner wall of the communicating cavity 51. When the sample adding unit 50 is at the first working position, as shown in fig. 4, the communication chamber 51 is communicated with the detection chamber 30 through the first communication hole 52, the outer wall of the second communication hole 53 is completely contacted with the inner wall of the channel 40, the channel 40 seals the second communication hole 53, and the mixing chamber 20 is not communicated with the detection chamber 30; when the sample adding unit is in the second working position, as shown in fig. 5, the communicating chamber 51 is still communicated with the detecting chamber 30 through the first communicating hole 52, at this time, part or all of the outer wall at the position of the second communicating hole 53 is exposed outside the channel 40, the communicating chamber 51 is communicated with the mixing chamber 20 through the second communicating hole 53, the detecting chamber 30 is communicated with the mixing chamber 20 through the communicating chamber 51, and the mixing chamber 20 is communicated with the detecting chamber 30.

When the sample adding unit 50 is in the first working position, the outer wall of the second communication hole 53 is completely contacted with the inner wall of the channel 40, and the channel 40 seals the second communication hole 53. The sealing by wall-to-wall contact is not as secure in practice, since the gap between the walls is difficult to eliminate, which may not be visible to the naked eye and which also risks leakage. Preferably, the sample addition unit 50 is provided with a sealing member 54, and the sealing member 54 can make a part of the sample addition unit 50 closely contact with the channel 40. When the apparatus main body 10 is in the normal state, the seal member 54 is located at a position lower than the second communication hole 53. The sealing element 54 is preferably an elastomeric sealing ring. When the sample adding unit 50 is in the first working position, the sealing element 54 is in contact with the channel 40 to seal the channel 40; when the sample adding unit 50 is in the second working position, the sealing element 51 is separated from the channel 40, and the channel is not sealed.

Referring to FIG. 5, when the inner wall of the sample adding unit 50 at the position of the second communication hole 53 is partially or completely exposed outside the channel 40, the mixing chamber 20 and the detection chamber 30 are in a communication state, and the mixed solution in the mixing chamber 20 cannot enter the detection chamber 30 for detection due to gravity, at this time, if the detection is to be performed, the device main body 10 needs to be turned upside down, and the mixed solution in the mixing chamber 20 can flow into the detection chamber 30 for detection, as shown in FIG. 6. The device body 10 thus comprises two operating positions: right side up and upside down.

Preferably, referring to fig. 4-5, the sample adding unit 50 further comprises an end cap 55, and the end cap 55 is detachably connected to the communicating chamber 51. When the end cover 55 is connected with the communication cavity 51, as shown in fig. 4, the communication cavity 51 is isolated from the outside; when the end cap 55 is separated from the communicating chamber 51, as shown in fig. 5, the communicating chamber 51 is communicated with the outside, and at this time, the liquid sample can be added into the communicating chamber 51 through the dropper, the adding amount of the liquid sample is controlled by the dropper, and meanwhile, in the sample adding process, the liquid outlet hole at the lower end of the dropper is lower than the position of the first connecting hole 52, so that the liquid sample is prevented from entering the detection chamber 30 through the first connecting hole 52 in the sample adding process.

Preferably, referring to fig. 4, the channel 40 extends into the detection chamber 30, and the length of the channel 40 should not be too short, at least longer than the length of the second communication hole 53 in the vertical direction, so as to ensure that the channel 40 can wrap the second communication hole 53. It should be noted that, in the above process, as long as the second communication hole 53 on the sample adding unit 50 is completely covered by the channel 40, and the sealing element 54 is in contact with the channel 40, the sample adding unit 50 is located at the first working position; if the second communication hole 53 of the sample adding unit 50 is partially or completely exposed out of the channel 40 and the sealing element 54 is separated from the channel 40, the sample adding unit 50 is located at the second working position. The first working position and the second working position herein do not mean an accurate and non-displaceable position of the sample adding unit 50 in the device main body 10, but the positions in a section are both the first working position or the second working position. The channel 40 can only extend into the detection chamber 30 but not into the mixing chamber 20, because if the channel 40 extends into the mixing chamber 20, a recessed area (similar to the recessed area formed by the channel 40 and the detection chamber 30 in fig. 4) is formed between the channel 40 and the mixing chamber 20, and when the device main body 10 is inverted, much of the mixed liquid remains in the recessed area and cannot flow into the detection chamber 30, so that the mixed liquid flowing into the detection chamber 30 is insufficient.

Preferably, the liquid sample detection device further includes a cover 70 for covering the detection cavity 30, the cover 70 is in threaded fit with the outer wall of the detection cavity 30, the cover 70 is connected to the sample adding unit 50, and the sample adding unit 50 can be switched from the first working position to the second working position by rotating the cover 70, so as to change the position relationship between the channel 40 and the first through hole 52 on the sample adding unit 50. The detection chamber 30 is also provided with an installation slot 32, the installation slot 32 is provided with a test element, the test element can be a test strip 33, and the test strip 33 generally comprises a sample application area, a marking area and a detection area. When the test strip 33 is placed, the device body 10 is in a state of being upright, the sample application area is placed at a position near the top of the detection chamber 30, when the device body 10 is inverted, the mixed solution enters the detection chamber 30 and then contacts the sample application area, and the lower end of the test strip 33 at this time starts to flow from bottom to top by virtue of capillary force to detect the analyte.

Since the sample addition unit 50 and the channel 40 are located inside the device, and the device main body 10 is generally opaque, the positional relationship between the second communication hole 53 of the sample addition unit 50 and the channel 40 cannot be observed from the outside of the device. However, due to the existence of the sealing element 54, when the sealing element 54 moves in the channel 40 along with the sample adding unit 50, friction is generated between the sealing element 54 and the inner wall of the channel 40, and the sample adding unit 50 is difficult to move; when the sealing member 54 is separated from the channel 40, there is no friction between the sealing member 54 and the inner wall of the channel 40, and the sample addition unit 50 becomes easy to move. In the above structure, when the sample adding unit 50 is at the first working position, it is difficult to rotate the cover 70; when the sample adding unit 50 is at the second working position, it is easier to rotate the cover 70; therefore, even if the device main body 10 is not transparent, the position between the second communication hole 53 and the channel 40 in the sample addition unit 50 can be expressed by the force required to rotate the cover 70.

Preferably, the entire device body 10 has a polyhedral shape, which is convenient for the inspector to hold and rotate the cover 70. In addition, the mixing chamber 20 in the device body 10 is indirectly communicated with the outside through the sensing chamber 30, the mixing chamber 20 cannot be directly communicated with the outside, and if the device body 10 is integrally formed, the processing of the mixing chamber 20 is very difficult during the production process. Preferably, the bottom of the device body 10 is provided with a bottom support 80, the bottom support 80 and the device body 10 are ultrasonically welded together, and the bottom support 80 and the device body 10 form the mixing chamber 20.

Preferably, the position of the device body 10 in the mounting groove 32 is transparent, so that the device does not need to be opened, and the result of the test strip 33 can be directly read by a tester from the outside conveniently.

For easy understanding of the technical features, the following description is made of the detection flow:

1. when the detection device is in the initial state (the detection device is in the factory state), referring to fig. 4, at this time, the sample adding unit 50 is in the first working position, the sealing element 54 is located in the channel 40 and seals the channel 40, the channel 40 completely covers the second communicating hole 53, the detection chamber 30 is not communicated with the mixing chamber 20, and the cover 70 is in the half-tightened state.

2. Sample adding: referring to fig. 5, the testing personnel screws the cover 70, the sample adding unit 50 is at the second working position, the sealing element 54 is separated from the channel 40, the communicating chamber 51 is communicated with the mixing chamber 20 through the second communicating hole 53, the testing personnel opens the end cap 55, a certain amount of liquid sample is added into the communicating chamber 51 through the dropper, the liquid sample flows into the mixing chamber 20 through the second communicating hole 53, the end cap 55 is closed, the shaking is carried out, and the liquid sample is dissolved to obtain the testing liquid.

3. And (3) detection: referring to FIG. 6, the examiner inverts the apparatus body 10, the mixture flows into the communicating chamber 51 through the second communicating hole 53, then flows into the detection chamber 30 from the first communicating hole 52 at the bottom of the communicating chamber 51 and contacts the sample application area of the test strip 33, and the test strip 33 starts to flow from bottom to top by capillary force and performs detection of the analyte.

The above description is only the specific embodiments of the present invention, but the protection scope of the present invention is not limited thereto, and any changes or substitutions that are not thought of through creative work should be covered within the protection scope of the present invention, and therefore, the protection scope of the present invention should be subject to the protection scope defined by the claims.

Claims (10)

1. A liquid sample detection device is characterized by comprising a mixing cavity, a detection cavity and a sample adding unit, wherein the mixing cavity, the detection cavity and the sample adding unit are arranged in a device main body, detection liquid is filled in the mixing cavity, a sample can be added into the mixing cavity, and after the sample is added, the detection liquid and the sample are mixed to obtain mixed liquid;

a test element is arranged in the detection cavity and used for detecting whether the mixed solution contains the analyte or not;

a communicating cavity is arranged in the sample adding unit;

the sample adding unit comprises two working positions: the mixing cavity and the detection cavity are in a non-communicated state when the sample adding unit is positioned at the first working position; when the sample adding unit is positioned at the second working position, the mixing cavity is communicated with the detection cavity through the communicating cavity.

2. The apparatus according to claim 1, wherein the mixing chamber and the detection chamber are connected by a channel.

3. The apparatus according to claim 2, wherein the channel extends into the detection chamber.

4. The apparatus according to claim 2, wherein the sample application unit is provided with a sealing member;

when the sample adding unit is positioned at the first working position, the sealing element is contacted with the channel to seal the channel;

when the sample adding unit is located at the second working position, the sealing element is separated from the channel, and the channel is not sealed.

5. The apparatus according to claim 1, wherein the communication chamber has a first communication hole and a second communication hole formed in an inner wall thereof.

6. The apparatus according to claim 5, wherein the detection chamber and the communication chamber are connected via a first communication hole.

7. The device for detecting the liquid sample according to claim 5, wherein the communication chamber and the mixing chamber are communicated through the second communication hole when the sample adding unit is in the second working position.

8. The device for testing liquid sample according to claim 1, wherein the sample application unit further comprises an end cap, and the end cap is detachably connected to the communication cavity.

9. The liquid sample detection device according to claim 8, wherein when the end cap is separated from the communication chamber, the communication chamber is communicated with the outside; when the end cover is connected with the communicating cavity, the communicating cavity is isolated from the outside.

10. The apparatus according to claim 1, further comprising a cover for covering the detection chamber, wherein the cover is connected to the sample application unit.

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