CN211863571U

CN211863571U - Microneedle

Info

Publication number: CN211863571U
Application number: CN201922340654.XU
Authority: CN
Inventors: 周珊; 陈秋; 高阳
Original assignee: Sichuan Zhongruichuangzhi Technology Co ltd
Current assignee: Sichuan Zhongruichuangzhi Technology Co ltd
Priority date: 2019-12-24
Filing date: 2019-12-24
Publication date: 2020-11-06
Anticipated expiration: 2029-12-24

Abstract

The utility model relates to the technical field of medical equipment, a micropin is disclosed, include: base and the base plate that is formed with a plurality of needle bodies, base and base plate laminating are in order to form a plurality of needle body spaces that are used for holding the medicine, and this micropin still includes: the laminating is at the semi-permeable membrane of needle body inner wall, semi-permeable membrane pointed end is equipped with the laser hole, laser hole and the most advanced micropore intercommunication of needle body, the needle body lateral wall is equipped with the sieve mesh. The utility model discloses a human back is pierced to the needle body of micropin, the hydrone of human body fluid is got into the semi-permeable membrane by the sieve mesh in, solid-state water-soluble medicine and high osmotic pressure auxiliary material dissolve and form high saturated solution to it forces the medicine to release the needle body outside through the laser hole of semi-permeable membrane and the micropore of needle body with high-speed and invariable speed to produce high osmotic pressure, has the rate of releasing medicine invariable, efficient advantage, and micropin simple structure is with low costs moreover, and convenient to use is fit for large batch production.

Description

Microneedle

Technical Field

The utility model relates to the technical field of medical equipment, in particular to a microneedle.

Background

Microneedles are a new technology that has been rapidly developed in recent years, and because of their advantages of accuracy, painlessness, high efficiency, convenience, etc., they are widely used in a variety of medical fields such as drug delivery systems and micro-sampling analysis systems. The size of the micro-needle is in micron order, the micro-needle lattice penetrates the stratum corneum of the skin in a reversible minimally invasive way to form a mechanical channel through which biological macromolecules can pass, the problem of reduced bioavailability of the drug due to the pH value of the gastrointestinal tract, digestive enzymes, liver first pass effect and the like in oral administration is avoided, and relatively stable blood concentration can be maintained; meanwhile, the pain of acupuncture and skin damage caused by injection administration are avoided, so that pain and wound are avoided.

At present, microneedle drug delivery systems are receiving more and more attention in the field of transdermal absorption of solid water-soluble drugs such as hydrophilic micromolecular drugs, polypeptides, protein drugs and the like, and particularly, great development and application prospects are realized by utilizing microneedle technology to realize slow release and controlled release performances of drugs. In order to solve the problems of slow release rate and low release efficiency of solid water-soluble drugs, the existing micro-needle usually needs an additional pressure control device and even an additional drug library, and has the disadvantages of complex structure, high cost, inconvenient use and unsuitability for mass production.

SUMMERY OF THE UTILITY MODEL

The utility model provides a micro-needle, which solves the technical problems that the prior art can not realize the high release efficiency and the constant speed of solid water-soluble drugs with low cost.

The utility model discloses a micro-needle, include: base and the base plate that is formed with a plurality of needle bodies, base and base plate laminating still include in order to form a plurality of needle body spaces that are used for holding the medicine: the laminating is at the semi-permeable membrane of needle body inner wall, semi-permeable membrane pointed end is equipped with the laser hole, laser hole and the most advanced micropore intercommunication of needle body, the needle body lateral wall is equipped with the sieve mesh.

Wherein the sieve holes are round holes with the radius of 19-21 mu m.

Wherein, the number of the sieve holes on the side wall of the needle body is 200-300.

Wherein, the needle body and the base plate are made of polymer material polylactic acid.

Wherein the base is made of a polymer material polylactic acid.

The utility model discloses a human back is inserted to the needle body of micropin, and the hydrone of human body fluid is dissolved by the sieve mesh and is formed high saturated solution in getting into the semi-permeable membrane to produce high osmotic pressure and force the medicine to release outside the needle body through the laser hole of semi-permeable membrane and the micropore of needle body with high-speed and invariable speed, have the advantage that medicine release efficiency is high, speed is invariable, micropin simple structure moreover, with low costs, and convenient to use is fit for large batch production.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without inventive exercise.

Fig. 1 is a schematic structural view of a microneedle according to the present invention;

FIG. 2 is an enlarged schematic view of FIG. 1 at the dashed box;

fig. 3 is a schematic view of the use of the microneedles of fig. 1.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.

The micro-needle of this embodiment is as shown in fig. 1-3, a base 1 and a substrate 3 formed with a plurality of needle bodies 2, the base 1 and the substrate 3 are attached to form a plurality of needle body spaces for containing a medicament. The microneedle of the present embodiment further comprises: the laminating is at the semi-permeable membrane 4 of needle body 2 inner wall, and semi-permeable membrane 4 closely laminates with needle body 2 inner wall surface promptly, and semi-permeable membrane 4 pointed end is equipped with laser hole 41, and laser hole 41 communicates with the sharp micropore 21 of needle body 2. The semi-permeable membrane 4 forms a closed drug-loading space in the whole needle body space for loading the solid water-soluble drug 5 (the solid water-soluble drug 5 is mixed with a high osmotic pressure auxiliary material which can be one or more of sodium chloride, lactose, fructose, glucose and mannitol). The side wall of the needle body 2 is provided with a sieve pore 22 for leading human body fluid molecules to enter the semi-permeable membrane 4 from the sieve pore 22. In this embodiment, the drug 5 delivered by the microneedle is initially in a solid state, the needle body 2 is inserted into the subcutaneous part of the human body, and after water molecules of body fluid of the human body enter the semi-permeable membrane 4 through the sieve pores 22, the drug 5 is dissolved to form a highly saturated solution (the water molecules are smaller, and the molecules of the drug solution are larger, so that the drug solution is subjected to one-way permeation), so that high osmotic pressure is generated to force the drug to be released out of the needle body 2 through the laser pores 41 of the semi-permeable membrane 4 and the micropores 21 of the needle body 2 at a high and constant rate.

When in use, the micro-needle can be combined with the classic acupoints of traditional Chinese medicine, thereby not only avoiding the pain caused by catgut embedding at the acupoints, but also improving the defect of low absorptivity of the applied acupoints and achieving the effect of synergistic curative effect.

Generally, the height of a microneedle body is 800 μm, the microneedle body is provided with a circular substrate of 300 μm × 300 μm, the thickness of the microneedle body is 20-40 μm, and according to the size of the microneedle, in the embodiment, the radius of the side screen hole 22 of the microneedle body 2 is 19-21 μm, so that water molecules can pass through rapidly, for example: 20 μm.

In this embodiment, when the radius of the sieve holes 22 is 19 to 21 μm, the number of the sieve holes 22 on the side surface of the needle body 2 is about 200 to 300, which not only ensures the mechanical stability of the side surface structure of the needle body 2, but also controls the rate of water molecule penetration. Therefore, the release rate of the medicinal solution can be controlled by setting the number of the sieve pores 22, and on the premise of ensuring the stability of the side structure of the needle body 2, the more the sieve pores 22 are, the faster the medicinal solution is released, thereby achieving the purposes of controlled release and high efficiency.

The needle body 2 and the base plate 3 are made of polymer material polylactic acid, which is a novel biodegradable high molecular material, can have good biocompatibility, can be generally used as an absorbable surgical suture line, has good mechanical strength, can be safely degraded even if being broken in tissues or skin, and can also promote the transdermal absorption of drugs to a greater degree.

The base 1 is also made of polylactic acid, which is a polymer material.

The above description is only for the preferred embodiment of the present invention, and is not intended to limit the present invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included within the protection scope of the present invention.

Claims

1. A microneedle, comprising: base and the base plate that is formed with a plurality of needle bodies, base and base plate laminating are in order to form a plurality of needle body spaces that are used for holding the medicine, its characterized in that still includes: the laminating is at the semi-permeable membrane of needle body inner wall, semi-permeable membrane pointed end is equipped with the laser hole, laser hole and the most advanced micropore intercommunication of needle body, the needle body lateral wall is equipped with the sieve mesh.

2. A microneedle according to claim 1, wherein the mesh is a circular hole having a radius of 19 to 21 μm.

3. The microneedle according to claim 2, wherein the number of the holes in the sidewall of the needle body is 200 to 300.