CN211718309U

CN211718309U - Reagent storage mechanism and chemiluminescence immunoassay analyzer

Info

Publication number: CN211718309U
Application number: CN201922113545.4U
Authority: CN
Inventors: 易奇浩
Original assignee: Shenzhen Dymind Biotechnology Co Ltd
Current assignee: Shenzhen Dymind Biotechnology Co Ltd
Priority date: 2019-11-28
Filing date: 2019-11-28
Publication date: 2020-10-20
Anticipated expiration: 2029-11-28

Abstract

The application relates to the technical field of medical biological assay, specifically provides a mechanism and chemiluminescence immunoassay appearance are deposited to reagent, and this reagent is deposited the mechanism and is included: the device comprises a reagent bin, a bearing bracket, a first rotary shaft seal and a rotary main shaft; the reagent bin comprises a bottom plate, a support bracket is arranged on the bottom plate, a first through hole is formed in the bottom plate, a first rotary shaft seal is arranged between the bottom plate and the support bracket, a second through hole is formed in the first rotary shaft seal, and the second through hole is communicated with the first through hole; one end of the rotating main shaft penetrates into the reagent bin through the first through hole and the second through hole and is abutted against the bearing bracket, and the rotating main shaft is matched with the first rotating shaft seal to seal a gap between the rotating main shaft and the bearing bracket. Through the mode, the refrigerating effect of the reagent bin can be guaranteed, and the condensed water in the reagent bin is prevented from overflowing to corrode or damage other components.

Description

Reagent storage mechanism and chemiluminescence immunoassay analyzer

Technical Field

The utility model relates to a medical treatment biological chemical examination technical field, concretely relates to mechanism and chemiluminescence immunoassay appearance are deposited to reagent.

Background

In the field of in vitro diagnosis, in order to ensure the accuracy of a detection result, a detection reagent generally needs to be refrigerated for storage, so that the storage period of the reagent is prolonged. In an in vitro diagnostic apparatus, a relatively sealed reagent chamber is typically used for storing reagents.

In the long-term research and development process of the present application, the inventor finds that gaps often exist between the rotating central shaft and the reagent disk in the prior art, and the gaps can cause cold air in the reagent bin to escape to the outside of the reagent bin, so that the refrigerating effect of the reagent bin is not ideal.

SUMMERY OF THE UTILITY MODEL

The application provides a mechanism and chemiluminescence immunoassay appearance are deposited to reagent can guarantee the refrigeration effect in reagent storehouse to prevent that the comdenstion water in the reagent storehouse from spilling over, corrodes or damages other components and parts.

In one aspect, the present application provides a reagent storage mechanism comprising: the device comprises a reagent bin, a bearing bracket, a first rotary shaft seal and a rotary main shaft; the reagent bin comprises a bottom plate, a support bracket is arranged on the bottom plate, a first through hole is formed in the bottom plate, a first rotary shaft seal is arranged between the bottom plate and the support bracket, a second through hole is formed in the first rotary shaft seal, and the second through hole is communicated with the first through hole; one end of the rotating main shaft penetrates into the reagent bin through the first through hole and the second through hole and is abutted against the bearing bracket, and the rotating main shaft is matched with the first rotating shaft seal to seal a gap between the rotating main shaft and the bearing bracket.

On the other hand, the application provides a chemiluminescence immunoassay analyzer, which comprises a reagent storage mechanism and a sample reagent analysis mechanism, wherein the sample reagent analysis mechanism is used for analyzing a sample added with a reagent in the sample reagent loading mechanism, and the reagent storage mechanism is the reagent storage mechanism.

The beneficial effect of this application is: be different from prior art's condition, the rotary main shaft of this application passes through outside motor drive and produces rotary motion, and at this moment, rotary main shaft forms the movive seal with the cooperation of first rotatory bearing seal, and then seals the clearance between rotary main shaft and the support bracket, reaches self-sealing's effect, has realized the inside and outside isolation in reagent storehouse, helps the inside heat preservation in reagent storehouse. Simultaneously, the inside comdenstion water that can produce of reagent storehouse in the refrigeration process, form the dynamic seal through rotatory main shaft and the cooperation of first rotatory bearing seal, prevent effectively that the comdenstion water in the reagent storehouse from spilling over, corroding or damaging other components and parts.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts. Wherein:

FIG. 1 is a schematic view of a reagent storage mechanism according to a first embodiment of the present application;

FIG. 2 is a schematic view of a portion of a reagent storage mechanism according to a second embodiment of the present application;

FIG. 3 is a schematic view of a part of a reagent storage mechanism according to a third embodiment of the present application;

FIG. 4 is a schematic view of a reagent storage mechanism according to a fourth embodiment of the present application;

FIG. 5 is a schematic view of a portion of a reagent storage mechanism according to a fifth embodiment of the present application;

FIG. 6 is a schematic structural view of a reagent storage mechanism according to a sixth embodiment of the present application.

Detailed Description

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

In the existing in vitro diagnostic products (IVD), the reagent chambers of full-automatic chemiluminescence instruments and other instruments generally need to have the functions of rotary mixing, refrigeration, kit identification and the like. There will be a reagent bottle (the magnetic bead reagent bottle of calling down) that loads magnetic bead solution usually in the kit, the usual realization mode of mixing of magnetic bead solution is that outside motor drives the kit and bears the weight of the rotation of coiling reagent storehouse center pin, the below of magnetic bead reagent bottle is provided with gear structure usually in the kit to make magnetic bead reagent bottle with install the external gear meshing in the reagent storehouse in order to produce the rotation, the disturbance through the interior thick liquid piece of magnetic bead reagent bottle makes the interior solution of bottle form the vortex, the magnetic bead solution in the magnetic bead reagent bottle of mixing from this. The reagent cabin is used for storing the reagent box, the temperature in the reagent cabin is usually 2-8 ℃, the reagent cabin is usually provided with a heat insulation structure, the heat exchange between the reagent cabin and the outside is reduced, and the refrigeration efficiency is improved.

During the long development process, the inventor of the application finds that in the prior art, gaps often exist between the rotating central shaft and the reagent disk, and the gaps can cause cold air in the reagent bin to escape to the outside of the reagent bin. In addition, parts such as the rotating main shaft and the like are usually processed by metal such as aluminum alloy and the like, and the aluminum alloy has higher heat conductivity coefficient, so that the cold quantity in the reagent bin is extremely easy to be conducted to the outside of the bin through the rotating main shaft, the cold quantity in the bin is leaked, the refrigerating effect of the reagent bin is not ideal, and when the rotating main shaft and the outside temperature are uneven to generate heat exchange, condensed water can be generated and can overflow out of the bin body through a gap, and the condensed water can possibly enter a moving part or an electric part to cause component damage.

Therefore, the present application provides a reagent storage mechanism to solve the drawbacks of the prior art.

As shown in fig. 1 and 4, the reagent storage mechanism 100 of the embodiment of the present application includes a reagent cartridge 110, a support bracket 120, a first rotary shaft seal 130, and a rotary spindle 140.

The reagent cartridge 110 includes a bottom plate 111, a cartridge wall (not shown) disposed on the bottom plate 111, and a top cover (not shown) disposed on the cartridge wall, wherein the bottom plate 111 has a first through hole 101. Wherein, can be equipped with reagent on the top cap and get and put the mouth (not shown), be convenient for change or supply the reagent in the reagent storehouse 110, need not open the top cap completely simultaneously, reduced the heat exchange, avoided the loss of a large amount of air conditioning.

The supporting bracket 120 is disposed on the bottom plate 111, wherein a reagent to be mixed is pre-loaded into a magnetic bead reagent bottle (not shown), the magnetic bead reagent bottle loaded with the reagent is placed into the positioning hole 121 of the supporting bracket 120, and the supporting bracket 120 rotates to drive the magnetic bead reagent bottle in the reagent bin 110 to rotate, so that the reagent in the magnetic bead reagent bottle is in a suspension mixing state due to the rotation.

The first rotary shaft seal 130 is disposed between the bottom plate 111 and the support bracket 120, a second through hole 102 is formed on the first rotary shaft seal 130, and the second through hole 102 is communicated with the first through hole 101. Preferably, the second through hole 102 is coaxially disposed with the first through hole 101. One end of the rotary spindle 140 extends into the reagent chamber 110 through the first through hole 101 and the second through hole 102 and abuts against the support bracket 120, and the rotary spindle 140 is engaged with the first rotary shaft seal 130 to seal a gap between the rotary spindle 140 and the support bracket 120.

As shown in fig. 2, the first rotary shaft seal 130 may be composed of a slip ring filled with teflon and a rubber O-ring providing elasticity for sealing a rod, a shaft, a pin, a rotary joint, etc. having a rotary or oscillating motion.

Be different from prior art's condition, the rotary main shaft of this application passes through outside motor drive and produces rotary motion, and at this moment, rotary main shaft forms the movive seal with the cooperation of first rotatory bearing seal, and then seals the clearance between rotary main shaft and the support bracket, reaches self-sealing's effect, has realized the inside and outside isolation in reagent storehouse, helps the inside heat preservation in reagent storehouse. Simultaneously, the inside comdenstion water that can produce of reagent storehouse in the refrigeration process, form the dynamic seal through rotatory main shaft and the cooperation of first rotatory bearing seal, prevent effectively that the comdenstion water in the reagent storehouse from spilling over, corroding or damaging other components and parts.

As shown in fig. 3, the first rotary shaft seal 130 of the present embodiment includes: the first rubber ring body 131. The first rubber ring body 131 is radially formed with a first lip structure 132 facing the rotation main shaft 140, the first lip structure 132 is composed of a first upper lip 1311 abutting against the outer peripheral wall of the rotation main shaft 140, a first lower lip 1312 connected to the outer peripheral wall of the rotation main shaft 140, and a first indentation 1313 connecting the first upper lip 1311 and the first lower lip 1312, wherein a dynamic seal is formed between the first lip structure 132 and the rotation main shaft 140.

Specifically, the first rubber ring body 131 may be made of nitrile rubber or fluorine rubber, the radial length of the first upper lip 1311 is greater than the radial length of the first lower lip 1312, the thickness of the first upper lip 1311 is greater than the thickness of the first lower lip 1312, and the contact area of the first upper lip 1311 with the outer peripheral wall of the rotation spindle 140 is greater than the contact area of the first lower lip 1312 with the outer peripheral wall of the rotation spindle 140.

The first rotary shaft seal 130 in this embodiment has a sealing lip structure, the material of the lip structure is completely different from that of the conventional oil seal, and the sealing performance and the service life of the lip structure are far better than those of the conventional oil seal.

The material of the rotating main shaft 140 in the above embodiment is engineering plastic, and the engineering plastic is at least one of polycarbonate, polyamide, and polyacetal. The first rotary shaft seal 130 is made of a high-performance wear-resistant material, so that the friction coefficient between the first rotary shaft seal 130 and the outer peripheral wall of the rotary spindle 140 is small, the wear is low, the shaft power loss can be effectively reduced, and the economic benefit is improved.

Specifically, the engineering plastic may be polyetheretherketone, polyketone, fluoropolymer, liquid crystal polymer, polyvinylidene fluoride, polyphenylene sulfide polyphthalamide, polyamide, polycyclohexanedimethanol terephthalate, polybutylene terephthalate, polyethylene terephthalate, polyoxymethylene, modified polypropylene, ultra-high molecular weight polyethylene, high density polyethylene, or low density polyethylene.

In the embodiment, engineering plastics such as polycarbonate, polyamide, polyacetal, and the like are used as the materials of the direct contact part of the first rotating main shaft 140 and the air or the bin body in the reagent bin 110, and by utilizing the low thermal conductivity of the engineering plastics, the temperature rise in the reagent bin 110 caused by the conduction of heat can be effectively reduced, the refrigerating efficiency of the refrigerator of the reagent bin 110 is improved, and the problem of generating condensed water due to large temperature difference can be avoided. Meanwhile, the reagent chamber 110 is isolated from the outside air by the first rotary shaft seal 130, which helps to keep the temperature inside the reagent chamber 110. Because the inside of the reagent bin 110 can produce condensed water in the refrigeration process, the condensed water in the reagent bin 110 is prevented from overflowing, corroding or damaging other components and parts under the sealing action of the rotary shaft seal

As shown in fig. 4, the rotating main shaft 140 of the embodiment of the present application is a hollow structure, and the mechanism 100 further includes: main shaft 150 is fixed. Stationary spindle 150 is at least partially disposed within a cavity of rotating spindle 140.

The mechanism 100 of the embodiment of the present application further includes: and a rotation bearing 160. The rotary bearing 160 is disposed in the cavity of the rotary main shaft 140 and is sleeved on the outer peripheral wall of the fixed main shaft 150. Wherein, the inner peripheral wall of the rotary bearing 160 is engaged with the fixed main shaft 150, and the outer peripheral wall of the rotary bearing 160 is engaged with the rotary main shaft 140.

Specifically, the rotating main shaft 140 is of a hollow frame structure, the fixing main shaft 150 is at least partially disposed in the frame structure of the rotating main shaft 140, the rotating bearing 160 is disposed in a cavity of the rotating main shaft 140 and disposed in a gap between the fixing main shaft 150 and the rotating main shaft 140, wherein an inner peripheral wall of the rotating bearing 160 is engaged with the fixing main shaft 150, an outer peripheral wall of the rotating bearing 160 is engaged with the rotating main shaft 140, and when the rotating main shaft 140 rotates, the fixing main shaft 150 and the rotating main shaft 140 have the same rotation central axis and rotate synchronously.

As shown in fig. 4, the mechanism 100 of the embodiment of the present application further includes: an outer gear 170 and a spacer collar 180.

The outer gear 170 is disposed on a side of the support bracket 120 away from the bottom plate 111, the support bracket 120 is formed with a third through hole 103, the outer gear 170 is formed with a fourth through hole 104, and the fourth through hole 104 is communicated with the third through hole 103, the second through hole 102, and the first through hole 101. Preferably, the first through hole 101, the second through hole 102, the third through hole 103 and the fourth through hole 104 are coaxially arranged.

One end of the fixed main shaft 150 extends into the outer gear 170 through the first through hole 101, the second through hole 102, the third through hole 103, and the fourth through hole 104.

The isolation collar 180 is disposed on a side of the external gear 170 close to the support bracket 120, and the isolation collar 180 is sleeved on the outer peripheral wall of the fixed spindle 150 to prevent the fixed spindle 150 from directly contacting the support bracket 120.

As shown in fig. 4, the side of the outer gear 170 of the present embodiment adjacent the support bracket 120 abuts the spacer collar 180 to prevent the spacer collar 180 from rotating with the rotary shaft seal.

The material of the fixed main shaft 150 in the above embodiment is 6061 aluminum alloy, and the 6061 aluminum alloy has excellent characteristics of excellent processability, high toughness, no deformation after processing, compact material, no defect and the like, and is more favorable for preparing the fixed main shaft 150.

The material of the outer gear 170 in the above embodiment is nylon, which has sufficient elasticity and strength, and is good in impact resistance and not easily damaged.

The material of the isolating collar 180 in the above embodiment is engineering plastic, and the engineering plastic is at least one of polycarbonate, polyamide, and polyacetal. In the embodiment, engineering plastics such as polycarbonate, polyamide, polyacetal and the like are selected as the material of the isolating lantern ring 180, and the low thermal conductivity characteristic of the engineering plastics is utilized, so that the temperature rise in the reagent bin 110 caused by heat conduction can be effectively reduced, the refrigerating efficiency of the refrigerator of the reagent bin 110 is improved, and the problem of condensate water generated due to large temperature difference can be avoided.

As shown in fig. 5, the mechanism 100 of the embodiment of the present application further includes: a second rotary shaft seal 190 is disposed between the support bracket 120 and the spacer collar 180. The second rotary shaft seal 190 includes: the second rubber ring body 191 and the second rubber ring body 191 are axially formed with a second lip structure 192 facing the isolating collar 180, and the second lip structure 192 is composed of a second upper lip 1921 and a second lower lip 1922 abutting against the outer peripheral wall of the isolating collar 180, and a second indentation 1923 connecting the second upper lip 1921 and the second lower lip 1922. Wherein a dynamic seal is formed between the second lip structure 192 and the isolating collar 180.

The material of the second rotary shaft seal 190 is a high-performance wear-resistant material, so that the friction coefficient between the second rotary shaft seal 190 and the outer peripheral wall of the isolation lantern ring 180 is small, the abrasion is low, the shaft power loss can be effectively reduced, and the economic benefit is improved.

Specifically, the second rubber ring body 191 may be made of nitrile rubber or fluorine rubber, the length of the second upper lip 1921 is greater than the axial length of the second lower lip 1922, the thickness of the second upper lip 1921 is greater than the thickness of the second lower lip 1922, and the contact area between the second upper lip 1921 and the outer peripheral wall of the rotary spindle 140 is greater than the contact area between the second lower lip 1922 and the outer peripheral wall of the rotary spindle 140.

The hardness of the material of the second rotary shaft seal 190 in the above-described embodiment is greater than the hardness of the material of the isolating collar 180.

As shown in fig. 6, the rotating spindle 140 of the embodiment of the present application is connected to the support bracket 120, and the mechanism 100 further includes: and the motor 105, the motor 105 is arranged outside the reagent bin 110, and the motor 105 is used for driving the rotating main shaft 140 to rotate through synchronous pulley transmission so as to enable the support bracket 120 to rotate along with the rotating main shaft 140.

Further, the reagent chamber 110 further includes an insulating layer (not shown) and a chamber cover (not shown), so that the reagent chamber 110 is in a relatively insulating and sealed state. The insulating layer encloses the reagent storage mechanism 100 therein, and keeps the reagent in the reagent compartment 110 in a constant temperature state. The reagent cartridge 110 also includes a reagent cartridge 110 refrigeration mechanism 100 for refrigerating the reagent cartridge 110. In one embodiment, the refrigeration mechanism 100 is selected to be a semiconductor refrigeration chip.

In one embodiment, the refrigeration mechanism 100 is disposed at the bottom of the reagent cartridge 110. The reagent cartridge 110 further includes a reagent bottle zero sensor (not shown) for determining an initial position of the reagent cartridge 110.

The application provides a chemiluminescence immunoassay appearance, deposit mechanism and sample reagent analysis mechanism including reagent, sample reagent analysis mechanism is arranged in the sample that adds the reagent in the analysis sample reagent loading mechanism after, and the mechanism is deposited for aforementioned reagent to reagent is deposited to reagent. Please refer to the above embodiments for the specific structure of the reagent storage mechanism, which is not described herein.

The above description is only for the purpose of illustrating embodiments of the present application and is not intended to limit the scope of the present application, and all modifications of equivalent structures and equivalent processes, which are made by the contents of the specification and the drawings of the present application or are directly or indirectly applied to other related technical fields, are also included in the scope of the present application.

Claims

1. A reagent storage mechanism, the mechanism comprising: the device comprises a reagent bin, a bearing bracket, a first rotary shaft seal and a rotary main shaft;

the reagent bin comprises a bottom plate, the supporting bracket is arranged on the bottom plate, wherein a first through hole is formed in the bottom plate,

the first rotary shaft seal is arranged between the bottom plate and the support bracket, a second through hole is formed in the first rotary shaft seal, and the second through hole is communicated with the first through hole;

one end of the rotating main shaft penetrates into the reagent bin through the first through hole and the second through hole and is abutted against the bearing bracket, and the rotating main shaft is matched with the first rotating shaft seal to seal a gap between the rotating main shaft and the bearing bracket.

2. The mechanism of claim 1,

the first rotary shaft seal comprises: the first rubber ring body is axially provided with a first lip structure facing the rotating main shaft, and the first lip structure consists of a first upper lip abutted against the outer peripheral wall of the rotating main shaft, a first lower lip connected with the outer peripheral wall of the rotating main shaft and a first concave part connected with the first upper lip and the first lower lip;

and a dynamic seal is formed between the first lip structure and the rotating main shaft.

3. The mechanism of claim 1,

the material of the rotating main shaft is engineering plastics, and the engineering plastics are at least one of polycarbonate, polyamide and polyacetal;

the first rotary shaft seal is made of a high-performance wear-resistant material.

4. The mechanism of claim 1, wherein the rotating spindle is a hollow structure, the mechanism further comprising: fixing the main shaft;

the stationary spindle is at least partially disposed within the cavity of the rotating spindle.

5. The mechanism of claim 4, further comprising: the rotating bearing is arranged in the cavity of the rotating main shaft and sleeved on the outer peripheral wall of the fixed main shaft;

wherein, swivel bearing's internal perisporium with fixed main shaft cooperation, swivel bearing's periphery wall with swivel main shaft cooperation.

6. The mechanism of claim 4, further comprising: an outer gear and an isolation collar;

the outer gear is arranged on one side, far away from the bottom plate, of the support bracket, a third through hole is formed in the support bracket, a fourth through hole is formed in the outer gear, and the fourth through hole is communicated with the third through hole, the second through hole and the first through hole;

one end of the fixed main shaft penetrates into the outer gear through the first through hole, the second through hole, the third through hole and the fourth through hole;

the isolation lantern ring is arranged on one side, close to the bearing bracket, of the outer gear, and the isolation lantern ring is sleeved on the outer peripheral wall of the fixed main shaft so as to prevent the fixed main shaft from being in direct contact with the bearing bracket;

one side of the external gear, which is close to the support bracket, is abutted against the isolation lantern ring so as to prevent the isolation lantern ring from rotating along with the rotary shaft seal.

7. The mechanism of claim 6,

the fixed main shaft is made of 6061 aluminum alloy;

the outer gear is made of nylon;

the isolation lantern ring is made of engineering plastics, and the engineering plastics are at least one of polycarbonate, polyamide and polyacetal.

8. The mechanism of claim 6, further comprising: a second rotary shaft seal disposed between the support bracket and the isolation collar;

the second rotary shaft seal comprising: the second rubber ring body is axially provided with a second lip structure facing the isolating lantern ring, and the second lip structure consists of a second upper lip and a second lower lip which abut against the outer peripheral wall of the isolating lantern ring and a second concave part connecting the second upper lip and the second lower lip;

wherein a dynamic seal is formed between the second lip structure and the isolating lantern ring;

the second rotary shaft seal is made of a high-performance wear-resistant material.

9. The mechanism of claim 1, wherein the rotating spindle is coupled to the support bracket, the mechanism further comprising: the motor is arranged outside the reagent bin; the motor is used for driving the rotating main shaft to rotate through the transmission of the synchronous belt pulley, so that the supporting bracket rotates along with the rotating main shaft.

10. A chemiluminescent immunoassay analyzer comprising a reagent storage mechanism and a sample reagent analysis mechanism, wherein the sample reagent analysis mechanism is used for analyzing a sample added with a reagent in the sample reagent loading mechanism, and the reagent storage mechanism is the reagent storage mechanism according to any one of claims 1 to 9.