CN217725326U

CN217725326U - Even mechanism is shaken in kit storage storehouse

Info

Publication number: CN217725326U
Application number: CN202123366319.0U
Authority: CN
Inventors: 张昕; 张嘉珺; 潘吉源
Original assignee: Chongqing Guoke Medical Technology Development Co ltd; Suzhou Institute of Biomedical Engineering and Technology of CAS
Current assignee: Chongqing Guoke Medical Innovation Technology Development Co ltd; Suzhou Institute of Biomedical Engineering and Technology of CAS
Priority date: 2021-12-29
Filing date: 2021-12-29
Publication date: 2022-11-04
Anticipated expiration: 2031-12-29

Abstract

The utility model provides a reagent box storage storehouse shakes even mechanism, the setting is in the reagent box cavity in reagent box storage storehouse, the inside rotation of reagent box cavity is provided with the reagent dish, it is provided with multiunit kit to follow its even array of circumferencial direction on the reagent dish, one side department that every group kit is close to the reagent dish centre of a circle is provided with shakes even support and is shaking even support internal rotation and be provided with the magnetic bead box, shake even mechanism including shaking even driving piece, shake even guide, shake even driving piece setting on the reagent dish and with shake the magnetic bead box transmission on the even support and be connected, shake even driving piece setting and stretch into reagent box storage storehouse bottom and in reagent box cavity with shake even driving piece drive connection and take place the rotation in order to drive a plurality of magnetic bead boxes that shake even support, still be provided with on the reagent box cavity bottom surface shake even guide and with shake the inboard contact of circumference of even driving piece with the restriction and shake the axial displacement of driving piece. The utility model discloses every magnetic bead box all takes place the rotation to make kit storage storehouse accord with the requirement of immunodetection principle.

Description

Even mechanism is shaken in kit storage storehouse

Technical Field

The invention relates to the technical field of biochemical immunoassay equipment, in particular to a shaking mechanism of a kit storage bin applied to a biochemical immunoassay all-in-one machine.

Background

Biochemical analysis is one of the most important tools commonly used for clinical diagnosis. Various biochemical indexes are determined by analyzing blood or other body fluids, and comprehensive analysis is performed by combining with other clinical data, so that the diagnosis of diseases can be facilitated, the function of organs can be evaluated, and concurrent factors can be identified, the standard of treatment can be determined, and the like. The biochemical analyzer is mainly used for the quantitative determination of biochemical and chemical components of clinical blood and other body fluid samples, such as hemoglobin, cholesterol, triglyceride, albumin, C-reactive protein, glucose, potassium, sodium, calcium and the like, and is one of the most commonly used detection instruments for clinical analysis.

In the biochemical analysis process, the reagent is used for reacting with a sample to produce a reactant to be detected for clinical observation, and the storage mechanism of the reagent has higher requirements, namely low-temperature storage is generally required. Simultaneously, because the magnetic bead in the reagent inside is placed still for a long time and is formed the sediment easily, influences the concentration of the magnetic bead in the reagent inside, in order to improve the accuracy and the stability of reagent testing result, need carry out the mixing to the magnetic bead in the reagent, so kit storage mechanism still need possess shake even function. In the prior art, the full-automatic reagent box storage mechanism usually adopts the shaking mode that shaking the whole reagent box to realize the shaking of the reagent, the shaking mode has large amplitude, and easily generates certain destructiveness to the reagent box, and meanwhile, the whole shaking mode is uneven in the shaking performance of each reagent to be tested, so that the reagent cannot be guaranteed to be in the best state.

Disclosure of Invention

In view of this, the utility model aims at providing a reagent box storage storehouse shakes even mechanism to solve the problem that prior art exists.

In order to achieve the purpose, the utility model adopts the technical proposal that:

the utility model provides a reagent box storage storehouse shakes even mechanism, sets up in the reagent storehouse cavity in reagent box storage storehouse, the inside rotation of reagent storehouse cavity is provided with a reagent dish, the reagent dish is gone up and is provided with multiunit kit, every group along its even array of circumferencial direction the kit is close to one side department in the reagent dish centre of a circle is provided with one and shakes even support and shake even support internal rotation and be provided with the magnetic bead box, shake even mechanism including shake even driving piece, shake even driving member, shake even guide, shake even driving member setting on the reagent dish and with shake even on the support magnetic bead box transmission is connected, shake even driving piece setting and be in the bottom of reagent box storage storehouse and stretch into in the reagent storehouse cavity with shake even driving member drive and connect in order to drive a plurality ofly shake even on the support the magnetic bead box takes place the rotation, still be provided with on the bottom surface of reagent storehouse cavity shake even guide and with shake the inboard contact of circumference of driving member in order to restrict shake even axial displacement of driving member.

Preferably, the reagent chamber comprises an inner heat-insulating cover, an outer heat-insulating cover and a reagent chamber bottom plate, the inner heat-insulating cover and the outer heat-insulating cover are both arranged on the reagent chamber bottom plate and coaxially arranged, and the reagent disk is of a ring-shaped structure and is arranged between the inner heat-insulating cover and the outer heat-insulating cover.

As preferred, shake even driving piece including shake even carousel, shake even motor, shake even pivot and shake even gear, shake even carousel and rotate the setting for the circled structure and through a connecting chute and be in the inner circle circumference side department of reagent dish, it evenly is provided with a plurality ofly on the inner circle circumference side of even carousel and shakes even running gear, it runs through to shake even pivot the setting of reagent storehouse bottom plate and its be located the coaxial fixing of one end in the reagent storehouse cavity shakes even gear, shake even gear with shake even running gear meshing and connect, it sets up to shake even motor the bottom and its output shaft in reagent box storage storehouse with shake even pivot and be connected through a belt pulley subassembly transmission, shake even motor drive shake even pivot and rotate and warp shake even gear with the meshing transmission of even running gear, make it rotates along its circumferencial direction to shake even carousel.

Preferably, a plurality of transmission teeth are uniformly arranged on the circumferential side surface of the outer ring of the shaking turntable to form the shaking transmission member, a shaking rotation gear is fixedly arranged at the bottom of each magnetic bead box in a penetrating manner, the plurality of transmission teeth on the shaking turntable are in meshing connection with the shaking rotation gear at the bottom of each magnetic bead box, and the shaking motor drives the shaking rotation shaft to rotate and is in meshing transmission with the shaking rotation teeth through the shaking rotation gear and the shaking rotation gear at the bottom of each magnetic bead box, so that the plurality of magnetic bead boxes rotate.

Preferably, a water-blocking heat insulation sleeve is sleeved at the joint of the shaking rotating shaft and the reagent bin bottom plate.

Preferably, the shaking driving piece further comprises a shaking motor base, the shaking motor base is fixed to the bottom of the reagent box storage bin, a plurality of auxiliary supporting shafts are vertically arranged on the shaking motor base and fixedly connected with the bottom surface of the reagent bin bottom plate, the shaking rotating shaft is vertically arranged on the shaking motor base through a shaft fixing seat, the belt pulley assembly comprises a driving wheel, a driven wheel and a transmission belt, the driving wheel is coaxially fixed to an output shaft of the shaking motor, the shaking rotating shaft is not fixed to one end of the shaking gear, the driven wheel is coaxially fixed to one end of the shaking gear, and the driving wheel and the transmission belt are arranged between the driven wheel in a winding mode.

Preferably, the shaking guide part comprises a shaking guide groove and a plurality of shaking guide bodies, the shaking guide groove is concavely arranged on the circumferential side surface of the inner ring of the shaking turntable, the plurality of shaking guide bodies are uniformly fixed on the reagent bin bottom plate along the circumferential direction of the inner ring of the shaking turntable, and the plurality of shaking guide bodies are slidably embedded into the shaking guide groove to limit the axial displacement of the shaking turntable.

Preferably, the shaking guide body comprises a convex guide seat and a shaking guide wheel, the convex guide seat is fixed on the reagent bin bottom plate, the top of the convex guide seat is fixed with the shaking guide wheel through a bearing, the shaking guide wheel and the shaking turntable are coaxially arranged, the circumferential side surface of the shaking guide wheel is tangent to the tank bottom surface of the shaking guide groove, and the top surface and the bottom surface of the shaking guide wheel are respectively contacted with the top surface tank wall and the bottom surface tank wall of the shaking guide groove.

Compared with the prior art, the utility model provides a pair of even mechanism is shaken in kit storage storehouse will shake even mechanism design for adopt gear drive for every magnetic bead box all can take place the rotation, so that kit storage storehouse accords with the requirement of immunodetection principle, guarantees that the magnetic bead/magnetic particle in the reagent kit remain the free state throughout. Meanwhile, a shaking guide piece is arranged in the shaking mechanism to limit the axial movement of the shaking turntable, so that the shaking turntable can be ensured to rotate stably and is meshed with the shaking autorotation gear at the bottom of each magnetic bead box.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the description below are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a schematic view of the overall structure of a cartridge storage bin;

FIG. 2 is a schematic structural view of the interior of a reagent cartridge chamber;

FIG. 3 is a schematic structural view of FIG. 2 with the inner heat-insulating cover removed;

FIG. 4 is a cross-sectional view of the shake-up mechanism;

FIG. 5 is a schematic view of the construction of the shake-up drive;

fig. 6 is a schematic structural view of the shake-up guide.

Reference numerals and component parts description referred to in the drawings:

1. a reagent tray; 2. an inner heat-insulating cover; 3. an outer heat-insulating cover; 4. a reagent bin floor; 5. a kit; 6. shaking up the support; 7. a magnetic bead box; 8. shaking up the turntable; 9. shaking the motor uniformly; 10. shaking the rotating shaft uniformly; 11. shaking up the gears; 12. shaking up the motor base; 13. an auxiliary support shaft; 14. a shaft fixing seat; 15. a transmission gear; 16. shaking up the rotation gear; 17. a driving wheel; 18. a driven wheel; 19. a drive belt; 20. connecting the sliding chute; 21. shaking up the rotating teeth; 22. a water-blocking heat insulation sleeve; 23. shaking up the guide groove; 24. shaking up the guide body;

2401. a convex guide seat; 2402. and shaking up the guide wheels.

Detailed Description

The technical solution of the present invention will be described clearly and completely through the following detailed description. It is to be understood that the embodiments described are only some embodiments of the invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by a person skilled in the art without making creative efforts belong to the protection scope of the present invention.

Referring to fig. 1-6, a shaking mechanism for a reagent box storage bin is arranged in a reagent bin cavity of the reagent box storage bin, a reagent disk 1 is rotatably arranged in the reagent bin cavity, and in order to meet the requirement of low-temperature storage, a heat-insulating layer is required to be arranged in the reagent bin cavity, so that the reagent bin cavity is composed of an inner heat-insulating cover 2, an outer heat-insulating cover 3 and a reagent bin bottom plate 4. The inner heat-insulating cover 2 and the outer heat-insulating cover 3 are both arranged on the reagent bin bottom plate 4 and coaxially arranged, and the reagent tray 1 is specially arranged into a ring-shaped structure in order to match the structures of the inner heat-insulating cover 2 and the outer heat-insulating cover 3 and is arranged between the inner heat-insulating cover and the outer heat-insulating cover.

A plurality of groups of reagent boxes 5 are uniformly arrayed on the reagent disk 1 along the circumferential direction, a shaking support 6 is arranged at one side of each group of reagent boxes 5 close to the circle center of the reagent disk 1, and a magnetic bead box 7 is rotationally arranged in the shaking support 6. Because of the requirement of the immunoassay principle, the magnetic beads/magnetic particles in the kit 5 need to be kept in a free state all the time, and therefore the magnetic bead kit 7 needs to be shaken up continuously. The shaking mechanism provided in this embodiment mainly aims to drive each magnetic bead cassette 7 to rotate so as to mix the magnetic beads in the reagent.

Shake even mechanism including shake even driving piece, shake even driving medium, shake even guide, shake even driving medium setting on reagent dish 1 and with shake even magnetic bead box 7 transmission on the support 6 and be connected, shake even driving piece setting and stretch into reagent storehouse bottom and shake even driving medium drive and be connected and take place the rotation in order to drive a plurality of magnetic bead boxes 7 that shake on the even support 6 in the reagent storehouse cavity.

In this embodiment, the shake-up mechanism adopts a gear transmission mode. The shaking driving part comprises a shaking turntable 8, a shaking motor 9, a shaking rotating shaft 10, a shaking gear 11 and a shaking motor base 12. The shaking motor base 12 is arranged at the bottom of the reagent box storage bin and is vertically provided with a plurality of auxiliary supporting shafts 13 and is fixedly connected with the bottom surface of the reagent box bottom plate 4 so as to further support the reagent box storage bin. The shaking turntable 7 is of a ring-shaped structure and is rotatably arranged on the circumferential side surface of the inner ring of the reagent disk 1 through a connecting chute 20, and a plurality of shaking rotating teeth 21 are uniformly arranged on the circumferential side surface of the inner ring of the shaking turntable 7. Shaking even pivot 10 through a fixed seat 14 vertical setting shake even motor base 12 on, shake even pivot 10's top and run through reagent storehouse bottom plate 4 setting and stretch into the inside of reagent storehouse cavity simultaneously, be fixed with at this end department and shake even gear 11 and with shake even rotation tooth 21 meshing connection. The side surface of the circumference of the outer ring of the shaking-up turntable 8 is uniformly provided with a plurality of transmission teeth 15 to form a shaking-up transmission part, the bottom of each magnetic bead box 7 is fixedly provided with a shaking-up rotation gear 16 in a penetrating way, and the plurality of transmission teeth 15 on the shaking-up turntable 8 are meshed and connected with the shaking-up rotation gear 16 at the bottom of each magnetic bead box 7. The shaking motor 9 is arranged on the shaking motor base 12, an output shaft of the shaking motor is in transmission connection with the shaking rotating shaft 10 through a belt pulley assembly, the belt pulley assembly comprises a driving wheel 17, a driven wheel 18 and a transmission belt 19, the driving wheel 17 is coaxially fixed on the output shaft of the shaking motor 9, the driven wheel 18 is coaxially fixed at one end of the shaking rotating shaft 10, which is not fixed with the shaking gear 11, and the transmission belt 19 is wound between the driving wheel 17 and the driven wheel 18.

When the reagent box is stored in the reagent box storage bin, the shaking motor 9 continuously drives the shaking rotating shaft 10 to rotate and is in meshing transmission with the shaking rotating teeth 21 through the shaking gears 11 and the shaking rotation gears 16 at the bottoms of the magnetic bead boxes 7 through the transmission teeth 15, so that the magnetic bead boxes 7 rotate.

Furthermore, the joint of the shaking-up rotating shaft 10 and the reagent bin bottom plate 4 is sleeved with a water-blocking heat insulation sleeve 22, the water-blocking heat insulation sleeve 22 mainly has the function of preventing cold air in the cavity from being transmitted downwards along the shaking-up rotating shaft 10, and because the temperature of the air at the bottom of the reagent bin cavity is higher than that in the cavity, the cold shaking-up rotating shaft 10 can form condensate water which is attached to the condensate water and flows downwards to cause the corrosion of the shaft body and the bearing inside the shaft fixing seat 14, so the water-blocking heat insulation sleeve 22 is arranged to avoid the occurrence of the above conditions.

Because the shaking turntable 8 needs to be meshed with the shaking autorotation gears 16 at the bottoms of the plurality of magnetic bead boxes 7, the shaking turntable 8 needs to be kept stable when rotating, and cannot move axially, so that the shaking turntable is prevented from being separated from one or more shaking autorotation gears 16. Therefore, the reagent bin bottom plate 4 is also provided with a shaking guide part which is in contact with the inner side of the circumference of the shaking transmission part so as to limit the axial displacement of the shaking turntable 8.

The shaking guide part comprises a shaking guide groove 23 and a plurality of shaking guide bodies 24, the side surface of the inner ring circumference of the shaking turntable 8 is concavely provided with the shaking guide groove 23, the reagent chamber bottom plate 4 is uniformly fixed with the plurality of shaking guide bodies 24 along the inner ring circumference direction of the shaking turntable 8, and each shaking guide body 24 is embedded into the shaking guide groove 23 in a sliding manner so as to limit the axial displacement of the shaking turntable 8. The shaking guide body 24 comprises a convex guide seat 2401 and a shaking guide wheel 2402, the convex guide seat 2401 is fixed on the reagent bin bottom plate 4, the shaking guide wheel 2402 is fixed at the top of the convex guide seat through a bearing, the shaking guide wheel 2402 and the shaking turntable 8 are coaxially arranged, the circumferential side surface of the shaking guide wheel 2402 is tangent to the bottom surface of the shaking guide groove 23, and the top surface and the bottom surface of the shaking guide wheel 2402 are respectively contacted with the top surface groove wall and the bottom surface groove wall of the shaking guide groove 23. The steady rotation of the shaking guide disk 8 is ensured by the mutual restriction of the shaking guide wheel 2402 and the shaking guide groove 23.

The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. The utility model provides a reagent box storage storehouse shakes even mechanism, sets up in the reagent storehouse cavity in reagent box storage storehouse, its characterized in that: the reagent box comprises a reagent chamber, a reagent disk is arranged in the reagent chamber in a rotating mode, a plurality of groups of reagent boxes are evenly arrayed on the reagent disk in the circumferential direction, each group of reagent boxes is close to one side of the circle center of the reagent disk, a shaking support is arranged at one side of the reagent disk, a magnetic bead box is arranged in the shaking support in a rotating mode, a shaking mechanism comprises a shaking driving piece, a shaking driving piece and a shaking guide piece, the shaking driving piece is arranged on the reagent disk and connected with the magnetic bead box on the shaking support in a driving mode, the shaking driving piece is arranged at the bottom of a reagent box storage chamber and stretches into the reagent chamber, the reagent chamber is connected with the shaking driving piece in a driving mode to drive the magnetic bead boxes on the shaking support to rotate, and the bottom of the reagent chamber is further provided with the shaking guide piece and is in contact with the inner side of the circumference of the shaking driving piece to limit axial displacement of the shaking driving piece.

2. The shaking mechanism of the reagent kit storage bin according to claim 1, wherein: the reagent chamber comprises an inner heat-insulating cover, an outer heat-insulating cover and a reagent chamber bottom plate, wherein the inner heat-insulating cover and the outer heat-insulating cover are arranged on the reagent chamber bottom plate and coaxially arranged, and the reagent disk is of a ring-shaped structure and is arranged between the inner heat-insulating cover and the outer heat-insulating cover.

3. The shaking mechanism of the reagent box storage bin according to claim 2, wherein: shake even driving piece including shake even carousel, shake even motor, shake even pivot and shake even gear, shake even carousel and rotate the setting for the circle shape structure and through a connecting chute and be in the inner circle circumference side department of reagent dish, it evenly is provided with a plurality of even rotation teeth of shaking on the inner circle circumference side of even carousel to shake, it runs through to shake even pivot the reagent storehouse bottom plate setting and its is located one end coaxial fixation in the reagent storehouse cavity has shake even gear, shake even gear with shake even rotation teeth meshing and be connected, it sets up to shake even motor the bottom in reagent box storage storehouse and its output shaft with shake even pivot and be connected through a belt pulley subassembly transmission, shake even motor drive shake even pivot and pass through shake even gear with shake even rotation teeth's meshing transmission, make it rotates along its circumferencial direction to shake the carousel.

4. The shaking mechanism of the reagent kit storage bin according to claim 3, wherein: the utility model discloses a magnetic bead box, including shake even carousel, drive gear, even rotation gear, drive gear and every, shake even carousel and be provided with a plurality of driving teeth on the outer lane circumference side of shaking even carousel in order to constitute shake even driving medium, every the bottom of magnetic bead box all is fixed to wear to be equipped with one and shakes even rotation gear, shake a plurality of on the even carousel drive gear with every on the magnetic bead box bottom shake even rotation gear meshing connection, shake even motor drive shake even pivot and rotate and pass through shake even gear with shake even rotation gear's meshing, drive gear and every magnetic bead box bottom shake even rotation gear meshing transmission, make a plurality ofly the rotation takes place for the magnetic bead box.

5. The shaking mechanism of the reagent kit storage bin according to claim 3, wherein: the joint of the shaking rotating shaft and the reagent bin bottom plate is sleeved with a water-blocking heat insulation sleeve.

6. The reagent box storage bin shake-up mechanism of claim 3, wherein: shake even driving piece still including shaking even motor base, shake even motor base and fix on the bottom of kit storage storehouse, shake even motor base go up perpendicular be equipped with many auxiliary support axle and with the bottom surface fixed connection of reagent storehouse bottom plate, it is in to shake even pivot through a perpendicular setting of a fixing base shake even motor base, the pulley subassembly includes the action wheel, from driving wheel and driving belt, shake coaxially on the output shaft of even motor and be fixed with the action wheel, it is not fixed with to shake even pivot the coaxial one end of shaking even gear is fixed with from the driving wheel, the action wheel with around being equipped with between the driving wheel driving belt.

7. The reagent box storage bin shake-up mechanism of claim 3, wherein: shake even guide part including shaking even guide way and a plurality of even guide body of shaking, the concave interior circle circumference side of shaking even carousel is equipped with shake even guide way, follow on the reagent storehouse bottom plate the inner circle circumferencial direction of shaking even carousel evenly is fixed with a plurality of even guide bodies of shaking, and is a plurality of shake even guide body slip embedding shake in the even guide way with the restriction shake the axial displacement of even carousel.

8. The shaking mechanism of the reagent kit storage bin according to claim 7, wherein: shake even guide body including convex guide holder with shake even leading wheel, the convex guide holder is fixed on the reagent storehouse bottom plate and its top be fixed with through the bearing shake even leading wheel, shake even leading wheel with shake even carousel coaxial setting, shake the circumference side of even leading wheel with shake the tank bottom surface of even leading groove tangent, shake even leading wheel the top surface and the bottom surface respectively with shake the top surface cell wall, the bottom surface cell wall contact of even leading groove.