CN211426513U

CN211426513U - Full-automatic antibody pairing and screening equipment

Info

Publication number: CN211426513U
Application number: CN201921702579.0U
Authority: CN
Inventors: 张优金
Original assignee: Shenzhen Dongzhibao Biological Co ltd
Current assignee: Shenzhen Dongzhibao Biological Co ltd
Priority date: 2019-10-11
Filing date: 2019-10-11
Publication date: 2020-09-04
Anticipated expiration: 2029-10-11

Abstract

The utility model discloses a full-automatic antibody pairing and screening device, which comprises a bed body, a material placing module and an L-shaped mounting plate; the utility model has the advantages of reasonable design structurally, the during operation is got the sample micropore board through the clamping jaw clamp, and then the second motor drives the rotatory one hundred eighty degrees of xarm, and the second telescopic link drives the second stand and moves down to make the sample micropore board settle in putting the thing dish, the cross is got the silo and is made things convenient for clamping jaw work, and first motor passes through the driving gear and rotates, and then drives the carousel and put the thing dish and rotate, makes and put the thing dish and remove to L type mounting panel downside, first telescopic link drives the chemiluminescence scanner and moves down to screening detection to the antibody, and the continuation and the reliability that conveniently detect take away the sample micropore board to the process of moving down through getting the material module with the same principle, and full automation has reduced staff's intensity of labour, has improved screening detection efficiency, and hand and universal wheel make this device remove and settle swiftly.

Description

Full-automatic antibody pairing and screening equipment

Technical Field

The utility model relates to a biological screening equipment technical field specifically is a screening equipment is paird to full-automatic antibody.

Background

Biological products, particularly therapeutic monoclonal antibodies, have met with great success in the past decade or so. Historically, these antibodies directly target cancer cells and other disease cells by binding to and killing them. Driven by the field of immunotherapy, antibody-based therapies are undergoing a second wave; the workflow of antibody screening begins with hybridoma or other types of libraries in which scientists screen for binders to specific target molecules. The gold standard for this step is an ELISA method, which is very powerful and rapid, but also exotic. Only a single target can be found and bound at a time; the method can be used for pairing screening through a micro-lens technology, a micro-array technology, a chemiluminescence technology and the like, and after the reaction is finished, the target spot information of the antibody screening microporous plate is automatically scanned and analyzed through a chemiluminescence scanner.

At present, the automation degree of the existing antibody pairing screening equipment is low, the manual material taking and placing is needed, the screening and detection of a batch production line are not facilitated, the labor intensity of workers is high, and the detection efficiency is low. Accordingly, one skilled in the art provides a fully automated antibody pairing screening apparatus to solve the problems set forth in the background above.

Disclosure of Invention

An object of the utility model is to provide a screening installation is paird to full-automatic antibody to solve the problem that proposes in the above-mentioned background art.

In order to achieve the above object, the utility model provides a following technical scheme:

the utility model provides a screening installation is paird to full-automatic antibody, includes the bed body, blowing module and L type mounting panel, bed body upper end middle part rotates and is connected with the rotation axis, the rotation axis lower extreme runs through the bed body and is connected with driven gear, the rotation axis upper end is provided with the carousel, the equidistant a plurality of thing dishes of putting that are provided with of carousel upper end edge circumference, bed body upper end left side is provided with gets the material module, bed body upper end right side is provided with the blowing module, bed body upper end rear side is provided with L type mounting panel, L type mounting panel front end left side and right side symmetry are provided with the direction litter, the direction litter passes through the sliding sleeve and connects the chemiluminescence scanner jointly, the chemiluminescence scanner lower extreme is provided with the sealing washer, L type mounting panel upper end is provided with first telescopic link, the.

As a further aspect of the present invention: bed body lower extreme left side and right side symmetry are provided with the supporting leg, the supporting leg lower extreme all is provided with the universal wheel, the bed body right-hand member is provided with the handle.

As a further aspect of the present invention: the bed body lower extreme right side is embedded to be provided with first motor, first motor is connected with the driving gear through the motor shaft, driven gear is connected in the meshing of driving gear.

As a further aspect of the present invention: the device is characterized in that a sample microporous plate is arranged in the object placing disc, a cross material taking groove is arranged in the middle of the upper end of the object placing disc, and a plurality of spherical supporting seats are circumferentially arranged at equal intervals at the upper end of the bed body and at the lower side of the rotary disc.

As a further aspect of the present invention: get material module and blowing module and all include first stand, gag lever post, second stand, second telescopic link, second motor, xarm and clamping jaw, first stand upper end has the second stand through a plurality of gag lever posts sliding connection, the embedded second telescopic link that is provided with in first stand upper end middle part, the second stand is connected to second telescopic link upper end, the embedded second motor that is provided with in second stand upper end, second motor upper end is provided with the xarm, xarm lower extreme left side and right side symmetry are provided with the clamping jaw, the model of clamping jaw is MGP 800.

Compared with the prior art, the beneficial effects of the utility model are that:

the utility model has the advantages of reasonable design structurally, the during operation is got the sample micropore board through the clamping jaw clamp, and then the second motor drives the rotatory one hundred eighty degrees of xarm, and the second telescopic link drives the second stand and moves down to make the sample micropore board settle in putting the thing dish, the cross is got the silo and is made things convenient for clamping jaw work, and first motor passes through the driving gear and rotates, and then drives the carousel and put the thing dish and rotate, makes and put the thing dish and remove to L type mounting panel downside, first telescopic link drives the chemiluminescence scanner and moves down to screening detection to the antibody, and the continuation and the reliability that conveniently detect take away the sample micropore board to the process of moving down through getting the material module with the same principle, and full automation has reduced staff's intensity of labour, has improved screening detection efficiency, and hand and universal wheel make this device remove and settle swiftly.

Drawings

FIG. 1 is a schematic structural diagram of a fully automatic antibody pairing and screening device.

FIG. 2 is a top view of a tray of a fully automated antibody pairing screening apparatus.

FIG. 3 is a schematic structural diagram of a discharging module in a full-automatic antibody pairing and screening apparatus.

In the figure, the bed body 1, supporting legs 2, universal wheels 3, a rotating shaft 4, a driven gear 5, a first motor 6, a driving gear 7, a rotating disc 8, a storage disc 9, a cross-shaped material taking groove 10, a material taking module 11, a material placing module 12, an L-shaped mounting plate 13, a guide sliding rod 14, a sliding sleeve 15, a chemical luminescence scanner 16, a sealing ring 17, a first telescopic rod 18, a sample micropore plate 19, a spherical supporting seat 20, a first upright 1101, a limiting rod 1102, a second upright 1103, a second telescopic rod 1104, a second motor 1105, a cross arm 1106 and a clamping jaw 1107 are arranged.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Referring to fig. 1 to 3, in the embodiment of the present invention, a fully automatic antibody pairing and screening apparatus includes a bed body 1, a material placing module 12 and an L-shaped mounting plate 13, wherein a rotating shaft 4 is rotatably connected to the middle of the upper end of the bed body 1, a driven gear 5 is connected to the lower end of the rotating shaft 4 through the bed body 1, a rotating disc 8 is arranged at the upper end of the rotating shaft 4, a plurality of material placing discs 9 are circumferentially arranged at equal intervals on the upper edge of the rotating disc 8, a material taking module 11 is arranged on the left side of the upper end of the bed body 1, the material placing module 12 is arranged on the right side of the upper end of the bed body 1, the L-shaped mounting plate 13 is arranged on the rear side of the upper end of the bed body 1, guide sliding rods 14 are symmetrically arranged on the left side and the right side of the front end of the, the upper end of the L-shaped mounting plate 13 is provided with a first telescopic rod 18, and the lower end of the first telescopic rod 18 is connected with a chemiluminescence scanner 16.

The left side and the right side symmetry of 1 lower extreme of the bed body are provided with supporting

leg

2, 2 lower extremes of supporting leg all are provided with

universal wheel

3, 1 right-hand member of the bed body is provided with the handle.

A first motor 6 is embedded in the right side of the lower end of the bed body 1, the first motor 6 is connected with a driving gear 7 through a motor shaft, and the driving gear 7 is meshed with a driven gear 5.

A sample micropore plate 19 is arranged in the object placing plate 9, a cross-shaped material taking groove 10 is arranged in the middle of the upper end of the object placing plate 9, and a plurality of spherical supporting seats 20 are circumferentially arranged at equal intervals at the upper end of the bed body 1 and at the lower side of the rotary plate 8.

Get material module 11 and blowing module 12 and all include first stand 1101, gag lever post 1102, second stand 1103, second telescopic link 1104, second motor 1105, xarm 1106 and clamping jaw 1107, there is second stand 1103 first stand 1101 upper end through a plurality of gag lever posts 1102 sliding connection, the embedded second telescopic link 1104 that is provided with in first stand 1101 upper end middle part, second stand 1103 is connected to second telescopic link 1104 upper end, the embedded second motor 1105 that is provided with in second stand 1103 upper end, second motor 1105 upper end is provided with the xarm 1106, xarm 1106 lower extreme left side and right side symmetry are provided with clamping jaw 1107, the model of clamping jaw 1107 is MGP 800.

The utility model discloses a theory of operation is:

the utility model relates to a full-automatic antibody pairing screening device, during operation, an external power supply and an ARM controller are communicated, a sample micropore plate 19 is clamped through a clamping jaw 1107, then a second motor 1105 drives a cross ARM 1106 to rotate one hundred eighty degrees, a second telescopic rod 1104 drives a second upright post 1103 to move downwards, so that the sample micropore plate 19 is arranged in a placing tray 9, a cross-shaped material taking groove 10 facilitates the work of the clamping jaw 1107, a first motor 6 drives a driven gear 5 and a rotating shaft 4 to rotate through a driving gear 7, so as to drive a rotary disc 8 and the placing tray 9 to rotate, so that the placing tray 9 moves to the lower side of an L-shaped mounting plate 13, the first telescopic rod 18 drives a chemiluminescence scanner 16 to move downwards along a guide slide bar 14 to carry out screening detection on the antibody, a sealing ring 17 ensures the sealing performance, the continuity and the reliability of the detection are convenient, and finally, the sample micropore plate 19 is moved downwards through a material, full automation has reduced staff's intensity of labour, has improved screening detection efficiency, and simultaneously under the effect of handle and universal wheel 3, this device removes to settle swiftly convenient, and area is little.

It is obvious to a person skilled in the art that the invention is not restricted to details of the above-described exemplary embodiments, but that it can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.

Claims

1. The utility model provides a screening installation is paird to full-automatic antibody, includes the bed body (1), blowing module (12) and L type mounting panel (13), its characterized in that, bed body (1) upper end middle part is rotated and is connected with rotation axis (4), rotation axis (4) lower extreme runs through the bed body (1) and is connected with driven gear (5), rotation axis (4) upper end is provided with carousel (8), carousel (8) upper end edge circumference is equidistant to be provided with a plurality of thing dishes (9), bed body (1) upper end left side is provided with gets material module (11), bed body (1) upper end right side is provided with blowing module (12), bed body (1) upper end rear side is provided with L type mounting panel (13), L type mounting panel (13) front end left side and right side symmetry are provided with direction litter (14), direction litter (14) connect chemiluminescence scanner (16) through sliding sleeve (15) jointly, chemiluminescence scanner (16) lower extreme is provided with sealing washer (17), L type mounting panel (13) upper end is provided with first telescopic link (18), chemiluminescence scanner (16) is connected to first telescopic link (18) lower extreme.

2. The full-automatic antibody pairing and screening equipment according to claim 1, wherein the left side and the right side of the lower end of the bed body (1) are symmetrically provided with supporting legs (2), the lower ends of the supporting legs (2) are respectively provided with a universal wheel (3), and the right end of the bed body (1) is provided with a handle.

3. The full-automatic antibody pairing and screening device according to claim 1, wherein a first motor (6) is embedded in the right side of the lower end of the bed body (1), the first motor (6) is connected with a driving gear (7) through a motor shaft, and the driving gear (7) is meshed with a driven gear (5).

4. The full-automatic antibody pairing and screening device according to claim 1, wherein a sample micro-porous plate (19) is arranged inside the object placing tray (9), a cross-shaped material taking groove (10) is arranged in the middle of the upper end of the object placing tray (9), and a plurality of spherical supporting seats (20) are circumferentially arranged at equal intervals at the upper end of the bed body (1) and at the lower side of the rotating disc (8).

5. The fully automatic antibody pairing-screening apparatus according to claim 1, the material taking module (11) and the material placing module (12) both comprise a first upright post (1101), a limiting rod (1102), a second upright post (1103), a second telescopic rod (1104), a second motor (1105), a cross arm (1106) and a clamping jaw (1107), the upper end of the first upright post (1101) is connected with a second upright post (1103) in a sliding way through a plurality of limiting rods (1102), a second telescopic rod (1104) is embedded in the middle of the upper end of the first upright post (1101), the upper end of the second telescopic rod (1104) is connected with a second upright post (1103), a second motor (1105) is embedded in the upper end of the second upright post (1103), the upper end of the second motor (1105) is provided with a cross arm (1106), the left side and the right side of the lower end of the cross arm (1106) are symmetrically provided with clamping jaws (1107), and the type of the clamping jaws (1107) is MGP 800.