CN105132283A - Hot lid mechanism of fluorescent quantitative PCR (polymerase chain reaction) instrument - Google Patents
Hot lid mechanism of fluorescent quantitative PCR (polymerase chain reaction) instrument Download PDFInfo
- Publication number
- CN105132283A CN105132283A CN201510518244.3A CN201510518244A CN105132283A CN 105132283 A CN105132283 A CN 105132283A CN 201510518244 A CN201510518244 A CN 201510518244A CN 105132283 A CN105132283 A CN 105132283A
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- Prior art keywords
- hot lid
- hot
- rotate
- mounting bracket
- screw
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
A hot lid mechanism of a fluorescent quantitative PCR (polymerase chain reaction) instrument comprises a mounting support. A screw which is rotatable is mounted on the mounting support. An upper end of the screw is connected with a transmission nut which drives the screw to rotate. The transmission nut is connected with an automatic mechanism which drives the transmission nut to rotate. A lower end of the screw is provided with a hot cover support which is driven by the screw to move up and down. The hot cover support is connected with a hot cover which may move up and down relative to the hot cover plate. The transmission nut is further connected with a manual mechanism which drives the hot cover to rotate when the hot cover jams. The hot cover is arranged into a structure capable of moving up and down relative to the hot cover support so as to adapt to test tubes of different heights, and application cost is greatly lowered. When the transmission nut operates, the automatic mechanism drives the nut to drive the screw to rotate, and the hot cover is thereby driven to move up and down; when the hot cover jams during reagent analysis, the transmission nut is driven by manual mechanism to rotate so as to drive the hot cover to move up and down, thereby eliminating jamming.
Description
Technical field
The present invention relates to the detection of biology and medical science, be specifically related to a kind of hot lid mechanism of quantitative real time PCR Instrument.
Background technology
Real-Time Fluorescent Quantitative PCR Technique can realize the quantitative analysis to DNA profiling, significant to molecular biology research and medical research etc.Very to current most of quantitative PCR apparatus because the distance that hot lid support moves up and down is certain, when heat lid is fixedly connected on hot lid support, the distance that moves up and down of heat lid is also certain, so the test tube of different heights can not be applicable to, or easily there is hot lid stuck phenomenon when analyzing in reagent, and do not open heat lid by automechanism when analyzing, affect the test result of reagent.
Summary of the invention
The invention provides and be a kind ofly applicable to the test tube of different heights, the hot lid mechanism of the quantitative real time PCR Instrument of heat extraction lid stuck phenomenon can be separated.
The technical solution used in the present invention is:
A kind of hot lid mechanism of quantitative real time PCR Instrument, comprise mounting bracket, described mounting bracket is provided with rotatable screw rod, the upper end of described screw rod is connected with the driving nut driving it to rotate, described driving nut is connected with its automechanism rotated of drive, the lower end of described screw rod is provided with and drives by it hot lid support moved up and down, it is characterized in that: described hot lid support is connected with energy its heat lid moved up and down relatively, described driving nut is also connected with the man-operated mechanism driving it to rotate when heat lid is stuck.The present invention's heat lid is arranged to the structure that moves up and down of relatively hot lid support to be used for adapting to the test tube of different heights, without the need to designing the hot lid mechanism of different miles of relative movement for the test tube of different heights, greatly reduces use cost.Drive by automechanism during driving nut work of the present invention and rotate thus drive bolt rotary, drive heat lid to move up and down, when reagent analysis, heat lid is stuck, and now manually mechanism drives driving nut to rotate, drive heat lid to move up and down, thus remove stuck phenomenon.
Further, between described mounting bracket and hot lid support, be also provided with backstay, facilitate hot lid support to be mounted opposite support and move up and down.
Further, described hot lid support is covered with heat and is connected by joint pin, and the relatively hot lid support of described joint pin can move up and down, and the external hot lid support of described joint pin and heat are set with compression spring between covering.Because joint pin can move up and down in decline process, so the relatively hot lid support of heat lid also can move up and down, the test tube of different heights so just can be used in.
Further, described automechanism comprises the stepper-motor be arranged on mounting bracket, the output shaft of described stepper-motor is provided with the first synchronous pulley, described first synchronous pulley is connected with the second synchronous pulley by Timing Belt, and described second synchronous pulley drives the driving nut rotated to be fixedly connected with by it.
Further, described man-operated mechanism comprises the worm screw be arranged on mounting bracket and the worm gear being driven rotation by worm screw, and described worm gear drives the driving nut rotated to be fixedly connected with by it.
Further, described worm screw is arranged on mounting bracket by worm bracket.
The invention has the beneficial effects as follows: be applicable to the test tube of different heights, heat extraction lid stuck phenomenon can be separated.
Accompanying drawing explanation
Fig. 1 is structural upright schematic diagram of the present invention.
Fig. 2 is side-view of the present invention.
Fig. 3 is use schematic diagram of the present invention.
Embodiment
Below in conjunction with specific embodiment, the present invention is further described, but does not limit the invention to these embodiments.One skilled in the art would recognize that all alternativess, improvement project and the equivalents that present invention encompasses and may comprise in Claims scope.
With reference to Fig. 1-3, a kind of hot lid mechanism of quantitative real time PCR Instrument, comprise mounting bracket 2, described mounting bracket 2 is provided with rotatable screw rod 15, the upper end of described screw rod 15 is connected with the driving nut 7 driving it to rotate, described driving nut 7 is connected with its automechanism rotated of drive, the lower end of described screw rod 15 is provided with and drives by it hot lid support 6 moved up and down, described hot lid support 6 is connected with can relative its heat lid 5 moved up and down, described driving nut 7 is also connected with heat cover 5 stuck time drive it to rotate man-operated mechanism.The present invention's heat lid 5 is arranged to the structure that moves up and down of relatively hot lid support 6 to be used for adapting to the test tube of different heights, without the need to designing the hot lid mechanism of different miles of relative movement for the test tube of different heights, greatly reduces use cost.Drive by automechanism when driving nut 7 of the present invention works and rotate thus drive screw rod 15 to rotate, drive heat lid 5 to move up and down, when reagent analysis, heat lid 5 is stuck, and now manually mechanism drives driving nut 7 to rotate, drive heat lid 5 to move up and down, thus remove stuck phenomenon.
Also be provided with backstay 8 between mounting bracket 2 and hot lid support 6 described in the present embodiment, facilitate hot lid support 6 to be mounted opposite support 2 and move up and down.
Hot lid support 6 described in the present embodiment is covered 5 with heat and is connected by joint pin 12, and the relatively hot lid support 6 of described joint pin 12 can move up and down, and the external hot lid support 6 of described joint pin 12 and heat are set with compression spring 11 between covering 5.Because joint pin 12 can move up and down in decline process, so heat lid 5 relatively hot lid supports 6 also can move up and down, the test tube of different heights so just can be used in.
Automechanism described in the present embodiment comprises the stepper-motor 1 be arranged on mounting bracket 2, the output shaft of described stepper-motor 1 is provided with the first synchronous pulley 3, described first synchronous pulley 3 is connected with the second synchronous pulley 14 by Timing Belt 4, and described second synchronous pulley 14 is fixedly connected with being driven the driving nut 7 rotated by it.
Man-operated mechanism described in the present embodiment comprises the worm screw 9 be arranged on mounting bracket 2 and the worm gear 13 being driven rotation by worm screw 9, and described worm gear 13 drives the driving nut 7 rotated to be fixedly connected with by it.
Described in the present embodiment, worm screw 9 is arranged on mounting bracket 2 by worm bracket 10.
When the present invention works, the first synchronous pulley 3 was with to rotate after stepper-motor 1 rotates, first synchronous pulley 3 rotates rear drive Timing Belt 4 and rotates, Timing Belt 4 rotates rear drive second synchronous pulley 14 and rotates, second synchronous pulley 14 rotates rear drive driving nut 7 and rotates, driving nut 7 takes screw rod 15 to after rotating and rotates, because screw rod 15 and backstay 8 are fixed on hot lid support 6, screw rod 15 is elevated the hot lid support 6 of rear drive and moves up and down, because heat lid 5 is fixed on hot lid support 6 by joint pin 12 and compression spring 11, so just drive heat lid 5 lifting, because joint pin 12 can move up and down in decline process, so just can adapt to the test tube of different heights.After experimental result, if test tube 16 occurs that stuck phenomenon can rotary worm 9 manually, because worm gear 13 is fixed on driving nut 7, hand rotation worm screw 9, worm gear 13 so just can be driven to rotate, thus drive driving nut 7 to rotate, thus drive heat lid 5 lifting, separate heat extraction lid 5 stuck phenomenon.
Claims (6)
1. the hot lid mechanism of a quantitative real time PCR Instrument, comprise mounting bracket, described mounting bracket is provided with rotatable screw rod, the upper end of described screw rod is connected with the driving nut driving it to rotate, described driving nut is connected with its automechanism rotated of drive, the lower end of described screw rod is provided with and drives by it hot lid support moved up and down, it is characterized in that: described hot lid support is connected with energy its heat lid moved up and down relatively, described driving nut is also connected with the man-operated mechanism driving it to rotate when heat lid is stuck.
2. the hot lid mechanism of a kind of quantitative real time PCR Instrument as claimed in claim 1, is characterized in that: be also provided with backstay between described mounting bracket and hot lid support.
3. the hot lid mechanism of a kind of quantitative real time PCR Instrument as claimed in claim 1, it is characterized in that: described hot lid support is covered with heat and is connected by joint pin, the relatively hot lid support of described joint pin can move up and down, and the external hot lid support of described joint pin and heat are set with compression spring between covering.
4. the hot lid mechanism of a kind of quantitative real time PCR Instrument as claimed in claim 1, it is characterized in that: described automechanism comprises the stepper-motor be arranged on mounting bracket, the output shaft of described stepper-motor is provided with the first synchronous pulley, described first synchronous pulley is connected with the second synchronous pulley by Timing Belt, and described second synchronous pulley drives the driving nut rotated to be fixedly connected with by it.
5. the hot lid mechanism of a kind of quantitative real time PCR Instrument as described in one of claim 1 ~ 4, it is characterized in that: described man-operated mechanism comprises the worm screw be arranged on mounting bracket and the worm gear being driven rotation by worm screw, and described worm gear drives the driving nut rotated to be fixedly connected with by it.
6. the hot lid mechanism of a kind of quantitative real time PCR Instrument as claimed in claim 5, is characterized in that: described worm screw is arranged on mounting bracket by worm bracket.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510518244.3A CN105132283A (en) | 2015-08-21 | 2015-08-21 | Hot lid mechanism of fluorescent quantitative PCR (polymerase chain reaction) instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510518244.3A CN105132283A (en) | 2015-08-21 | 2015-08-21 | Hot lid mechanism of fluorescent quantitative PCR (polymerase chain reaction) instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105132283A true CN105132283A (en) | 2015-12-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510518244.3A Pending CN105132283A (en) | 2015-08-21 | 2015-08-21 | Hot lid mechanism of fluorescent quantitative PCR (polymerase chain reaction) instrument |
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| Country | Link |
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| CN (1) | CN105132283A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022512630A (en) * | 2018-10-10 | 2022-02-07 | ファポン バイオテック インコーポレイテッド | Anti-human myocardial troponin I antibody and its applications |
| CN114806809A (en) * | 2022-06-09 | 2022-07-29 | 南京溯远基因科技有限公司 | PCR hot cover subassembly |
| WO2022257802A1 (en) * | 2021-06-09 | 2022-12-15 | 圣湘生物科技股份有限公司 | Cap heating device and nucleic acid detection apparatus |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101696443A (en) * | 2009-10-27 | 2010-04-21 | 西安天隆科技有限公司 | Method and device for reducing evaporation and nonspecific reaction in PCR amplification |
| CN102302959A (en) * | 2011-06-22 | 2012-01-04 | 张家林 | Pressure-adjustable thermal cover of thermocycler |
| CN103725602A (en) * | 2012-10-16 | 2014-04-16 | 常州福生生物技术有限公司 | Thermal cover plate used in nucleic acid amplification detector |
| CN104673667A (en) * | 2015-03-03 | 2015-06-03 | 杭州博日科技有限公司 | Thermal block of PCR (polymerase chain reaction) fluorescent quantitative analyzer |
| CN204939489U (en) * | 2015-08-21 | 2016-01-06 | 杭州安杰思生物科技有限公司 | A kind of hot lid mechanism of quantitative real time PCR Instrument |
-
2015
- 2015-08-21 CN CN201510518244.3A patent/CN105132283A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101696443A (en) * | 2009-10-27 | 2010-04-21 | 西安天隆科技有限公司 | Method and device for reducing evaporation and nonspecific reaction in PCR amplification |
| CN102302959A (en) * | 2011-06-22 | 2012-01-04 | 张家林 | Pressure-adjustable thermal cover of thermocycler |
| CN103725602A (en) * | 2012-10-16 | 2014-04-16 | 常州福生生物技术有限公司 | Thermal cover plate used in nucleic acid amplification detector |
| CN104673667A (en) * | 2015-03-03 | 2015-06-03 | 杭州博日科技有限公司 | Thermal block of PCR (polymerase chain reaction) fluorescent quantitative analyzer |
| CN204939489U (en) * | 2015-08-21 | 2016-01-06 | 杭州安杰思生物科技有限公司 | A kind of hot lid mechanism of quantitative real time PCR Instrument |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022512630A (en) * | 2018-10-10 | 2022-02-07 | ファポン バイオテック インコーポレイテッド | Anti-human myocardial troponin I antibody and its applications |
| JP7307158B2 (en) | 2018-10-10 | 2023-07-11 | ファポン バイオテック インコーポレイテッド | Anti-human cardiac troponin I antibody and application thereof |
| WO2022257802A1 (en) * | 2021-06-09 | 2022-12-15 | 圣湘生物科技股份有限公司 | Cap heating device and nucleic acid detection apparatus |
| CN114806809A (en) * | 2022-06-09 | 2022-07-29 | 南京溯远基因科技有限公司 | PCR hot cover subassembly |
| CN114806809B (en) * | 2022-06-09 | 2023-03-21 | 南京溯远基因科技有限公司 | PCR hot cover subassembly |
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Application publication date: 20151209 |
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| RJ01 | Rejection of invention patent application after publication |