CN210834864U

CN210834864U - Disintegration time limit instrument for drug detection

Info

Publication number: CN210834864U
Application number: CN201921025850.1U
Authority: CN
Inventors: 丁宗堃; 邢为藩
Original assignee: Nanjing Chenxiang Medical Research Co ltd
Current assignee: Nanjing Chenxiang Medical Research Co ltd
Priority date: 2019-07-03
Filing date: 2019-07-03
Publication date: 2020-06-23
Anticipated expiration: 2029-07-03

Abstract

The utility model discloses a medicine detects with time limit appearance that disintegrates, including base, stand, control box, the stand outer wall rotates and is equipped with the sleeve, and this sleeve upper portion lateral wall slides and even has a plurality of medicine pay-off units, and the fixed holding tank that disintegrates that is used for the medicine to disintegrate that is equipped with of sleeve lower part lateral wall is equipped with a plurality of baffles in the holding tank that disintegrates, and the baffle divide into a plurality of holding tank units that correspond with medicine pay-off unit that disintegrate, all is equipped with temperature sensor, pH detection meter, heating device on every holding tank unit inner wall, the utility model discloses time limit appearance that disintegrates is equipped with a plurality of units that can the independent operation, supports a plurality of experiments to go on in step, and is simple high-efficient, and can adjust in a flexible way between the unit, is convenient for looking over the record.

Description

Disintegration time limit instrument for drug detection

Technical Field

The utility model relates to a time limit appearance technical field, concretely relates to medicine detects with time limit appearance that disintegrates.

Background

It has been pointed out as early as decades ago that the absorption rate of a drug in vivo is often determined by the dissolution rate, the drug in a solid preparation must be disintegrated and dissolved before being absorbed and then converted into a solution, and if the drug is not easily released from the preparation or the dissolution rate of the drug is extremely slow, the absorption rate or degree of the drug in the preparation may be problematic, on the other hand, some drugs having strong pharmacological effects and small safety indexes, and drugs which are rapidly absorbed may cause significant adverse reactions if the dissolution rate is too fast, and the time for maintaining the drug effect is also shortened, in which case the dissolution rate of the drug in the preparation should be controlled.

The disintegration experiment of the existing disintegration time limit instrument is carried out in a manual operation mode, so that manpower is wasted, the result of the experiment is accurate enough, and meanwhile, when an operator operates, the problems of medicine contamination, external pollution and the like easily occur, so that the accuracy of the experiment result is influenced, and the operator is easily injured.

In addition, the existing disintegration time limit instrument has single function, can not operate a plurality of groups simultaneously, and has cross regulation and control and contrast, thereby greatly influencing the test process and efficiency.

Disclosure of Invention

The purpose of the invention is as follows: an object of the utility model is to prior art not enough, provide a medicine detects with time limit appearance that disintegrates, be equipped with a plurality of unit that can the exclusive operation, support a plurality of experiments to go on in step, simple high-efficient, and can adjust in a flexible way between the unit, be convenient for look over the record, contrast nature is strong, to the environmental isolation effect that disintegrates simultaneously, has improved the accuracy of experiment greatly.

The utility model provides a drug detection is with time limit appearance that disintegrates, includes the base, fixes the stand of locating base upper surface central authorities, locates the control box in the base, the stand outer wall rotates and is equipped with the sleeve, and this sleeve upper portion lateral wall slides even has a plurality of medicine pay-off units, and the fixed holding tank that disintegrates that is used for the medicine to disintegrate that is equipped with of sleeve lower part lateral wall is equipped with a plurality of baffles in the holding tank that disintegrates, and the baffle will disintegrate the holding tank and divide into a plurality of holding tank units that correspond with medicine pay-off unit, all is equipped with temperature sensor, pH detection meter.

As a further improvement of the utility model: the outer wall of the base is provided with a display panel and an operation panel which are connected with the control box, and the rear side of the base is provided with a power line which is connected with the control box.

As a further improvement of the utility model: medicine pay-off unit is equipped with 4 at least, the baffle is equipped with 4 at least, all communicate to have seted up inlet, leakage fluid dram corresponding to every holding tank unit on the holding tank outer wall that disintegrates.

As a further improvement of the utility model: the medicine feeding unit comprises a connecting rod and a storage basket fixedly arranged at the bottom end of the connecting rod, the storage basket comprises a bottom plate and side screen meshes vertically arranged on the edges of the four sides of the bottom plate, and the bottom plate and the side screen meshes are combined to form a cuboid cavity which is not sealed at the upper end and used for placing medicines.

As a further improvement of the utility model: the connecting rod is L shape structure, and the connecting rod upper end is equipped with the slider, and sleeve upper portion outer wall vertically is equipped with the spout of being connected with this slider adaptation, and the connecting rod lower extreme links firmly with bottom plate one side.

As a further improvement of the utility model: a positioning block provided with a screw hole is fixedly arranged on one side of the upper end of the connecting rod, and a positioning bolt used for limiting and fixing the medicine feeding unit is arranged on the screw hole in a matched mode.

As a further improvement of the utility model: the vertical section upper portion of connecting rod is equipped with the apron with holding tank unit top adaptation, the apron, the holding tank that disintegrates all adopt transparent material, and apron, holding tank, the baffle of disintegrating are the bilayer structure of inside evacuation.

Has the advantages that:

1. the utility model discloses the time limit appearance that disintegrates is equipped with medicine pay-off unit and holding tank unit that the multiunit corresponds, and the combination is the unit that can operate alone promptly, can support a plurality of experiments to go on in step, and simple high-efficient, and the holding tank that disintegrates can use the stand to rotate as the axle along with the sleeve, and the space accounts for than little, can adjust in a flexible way between the unit, is convenient for look over the record, and contrast nature is strong, effectively shortens the experimental period.

2. During operation, each electric appliance device (a temperature sensor, a pH detection meter and a heating device, can be directly purchased and installed on a commercially available product, is not limited by specific models and can meet the normal detection requirement of an experiment) is regulated and controlled through buttons on the operation panel, and then a detection data signal is fed back to the display panel.

3. The medicine feeding unit and the dissolving tank unit separated by the partition plate are matched to form an operation unit for a disintegration experiment, the specific number can be set according to requirements, and the number of the operation units is 4 in the figure. Each dissolving tank unit has independent inlet, drain outlet, is for the convenience independent control, if can simulate intestinal fluid environment, gastric juice environment, normal saline environment etc. be equipped with independent temperature sensor, pH detector, heating device simultaneously, and the integrality is strong, detects the ready degree height.

4. During the use, will wait to detect the medicine and place in putting the thing basket (the space that bottom plate, side screen cloth enclose), then the connecting rod that slides downwards for put the thing basket and soak in the simulation solution of dissolving tank unit, liquid passes through the side screen cloth (the screen cloth mesh can be selected according to the dissolved-out granularity of medicine) and gets into in putting the thing basket and contact the effect with the medicine, disintegrates.

5. The connecting rod links firmly between thing basket with putting, and the slip links to each other between the sleeve, and the connecting rod drives the thing basket up-and-down motion when gliding from top to bottom promptly.

6. After the medicine feeding unit moves to a proper position, the positioning bolt is rotatably inserted into the screw hole and abuts against the outer wall of the sleeve, and relative fixation can be realized. If the medicine feeding unit is filled with the medicine, the medicine feeding unit slides downwards to the disintegration groove unit, and when the medicine is completely soaked in the simulation liquid, the position and the height can be relatively fixed through the positioning bolt.

7. Set up the apron, with each holding tank unit cooperation of the holding tank that disintegrates, can form a relatively closed experimental space, reduced external factor's influence and pollution. In addition, apron, baffle, the holding tank that disintegrates all adopt the bilayer structure of inside evacuation, have effectively reduced the influence of the temperature transmission between the continuous operation unit, relative independence and accuracy when having guaranteed a plurality of experiments and going on.

Drawings

FIG. 1 is a schematic structural view of the present invention;

fig. 2 is a top view of the disintegration accommodation groove of the present invention;

fig. 3 is a top view of the medicine feeding unit of the present invention;

in the figure: the device comprises a base 1, a display panel 11, an operation panel 12, a power line 13, a column 2, a sleeve 3, a sliding chute 31, a medicine feeding unit 4, a connecting rod 41, a storage basket 42, a bottom plate 421, a screen on the side surface 422, a sliding block 43, a positioning block 44, a cover plate 45, a disintegration accommodating tank 5, a partition plate 51, an accommodating tank unit 52, a temperature sensor 53, a pH detection meter 54, a heating device 55, a liquid inlet 56 and a liquid outlet 57.

Detailed Description

In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the embodiments of the present invention are combined with the following description to clearly and completely describe the technical solution in the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by a person of ordinary skill in the art without creative efforts belong to the protection scope of the present invention.

A disintegration time limit instrument for drug detection is shown in figures 1 to 3 and comprises a base 1, a stand column 2 fixedly arranged in the center of the upper surface of the base 1, a control box arranged in the base 1, a display panel 11 and an operation panel 12 which are connected with the control box and arranged on the outer wall of the base 1, and a power line 13 connected with the control box and arranged on the rear side of the base 1.

2 outer wall rotations of stand are equipped with sleeve 3, and accessible ball bearing rotates between sleeve and stand to be connected, guarantee the sleeve can the stand rotate for the axis can, when the sleeve rotates, medicine pay-off unit on it, the holding tank that disintegrates rotate thereupon (relative static between the two), be convenient for observe different position operating unit's independent experiment progress, and is simple convenient.

The side wall of the upper part of the sleeve 3 is connected with a plurality of medicine feeding units 4 in a sliding manner, each medicine feeding unit 4 comprises a connecting rod 41 and a storage basket 42 fixedly arranged at the bottom end of the connecting rod 41, each storage basket 42 comprises a bottom plate 421 and side screen meshes 422 vertically arranged on the four side edges of the bottom plate 421 in a surrounding manner, the bottom plate 421 and the side screen meshes 422 are combined to form a cuboid cavity which is used for containing medicines and is not sealed at the upper end, the connecting rod 41 is of an L-shaped structure, a sliding block 43 is arranged at the upper end of the connecting rod 41, a sliding groove 31 which is in adaptive connection with the sliding block 43 is; a positioning block 44 provided with a screw hole is fixedly arranged on one side of the upper end of the connecting rod 41, a positioning bolt for limiting and fixing the medicine feeding unit 4 is arranged on the screw hole in a matched mode, and the relative fixation of the upper height position and the lower height position is realized through the insertion of the positioning bolt.

Connecting rod 41 vertical section upper portion be equipped with the apron 45 of holding tank unit 52 top adaptation, apron 45, the holding tank 5 that disintegrates all adopt transparent material, and apron 45, holding tank 5, the baffle 51 that disintegrates are the bilayer structure of inside evacuation, set up the apron, with each holding tank unit cooperation of the holding tank that disintegrates, can form a relatively closed experimental space, reduced external factor's influence and pollution. In addition, apron, baffle, the holding tank that disintegrates all adopt the bilayer structure of inside evacuation, have effectively reduced the influence of the temperature transmission between the continuous operation unit, relative independence and accuracy when having guaranteed a plurality of experiments and going on.

The fixed holding tank 5 that disintegrates that is used for the medicine to disintegrate that is equipped with of sleeve 3 lower part lateral wall, be equipped with a plurality of baffles 51 in the holding tank 5 that disintegrates, baffle 51 will disintegrate holding tank 5 and divide into a plurality of holding tank units 52 that correspond with medicine pay-off unit 4, all be equipped with temperature sensor 53 on every holding tank unit 52 inner wall, pH detects the meter 54, heating device 55 (temperature sensor, pH detects the meter, heating device purchase current device can, heating device can adopt heating wire heating or other conventional heating structure). The outer wall of the disintegration accommodating groove 5 is communicated with a liquid inlet 56 and a liquid outlet 57 corresponding to each accommodating groove unit 52.

The medicine feeding unit 4 is at least provided with 4 and the clapboard 51 is at least provided with 4. During the use, will wait to detect the medicine and place in putting the thing basket (the space that bottom plate, side screen cloth enclose), then the connecting rod that slides downwards for put the thing basket and soak in the simulation solution of dissolving tank unit, liquid passes through the side screen cloth (the screen cloth mesh can be selected according to the grain size of dissolving out of medicine) and gets into in putting the thing basket and contact with the medicine, disintegrates, and the record experiment data that disintegrates can.

The utility model discloses the time limit appearance that disintegrates is equipped with medicine pay-off unit and holding tank unit that the multiunit corresponds, and the combination is the unit that can operate alone promptly, can support a plurality of experiments to go on in step, and simple high-efficient, and the holding tank that disintegrates can use the stand to rotate as the axle along with the sleeve, and the space accounts for than little, can adjust in a flexible way between the unit, is convenient for look over the record, and contrast nature is strong, effectively shortens the experimental period. Meanwhile, the disintegration tester has an isolation effect on the disintegration environment, and the accuracy of an experiment is greatly improved.

It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.

The above embodiments are only used to illustrate the technical solution of the present invention, and not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention in its corresponding aspects.

Claims

1. The utility model provides a medicine detects with time limit appearance that disintegrates, includes the base, fixes the stand of locating base upper surface central authorities, locates the control box in the base, its characterized in that: the stand outer wall rotates and is equipped with the sleeve, this sleeve upper portion lateral wall slides even has a plurality of medicine pay-off units, medicine pay-off unit includes the connecting rod, the fixed thing basket of putting of locating the connecting rod bottom, it includes the bottom plate to put the thing basket, vertically enclose the side screen cloth of locating four side borders of bottom plate, the cuboid cavity that the upper end that the combination of side screen cloth formed and was used for placing the medicine was not sealed, the fixed holding tank that disintegrates that is used for the medicine to disintegrate that is equipped with of sleeve lower part lateral wall, be equipped with a plurality of baffles in the holding tank that disintegrates, the baffle divide into a plurality of holding tank units that correspond with medicine pay-off unit.

2. The disintegration time limit apparatus for drug testing according to claim 1, wherein: the base outer wall is provided with a display panel and an operation panel which are connected with the control box, and the rear side of the base is provided with a power line which is connected with the control box.

3. The disintegration time limit apparatus for drug testing according to claim 1, wherein: medicine pay-off unit is equipped with 4 at least, the baffle is equipped with 4 at least, all communicate to have seted up inlet, leakage fluid dram corresponding to every holding tank unit on the holding tank outer wall that disintegrates.

4. The disintegration time limit apparatus for drug testing according to claim 1, wherein: the connecting rod is L shape structure, and the connecting rod upper end is equipped with the slider, and sleeve upper portion outer wall vertically is equipped with the spout of being connected with this slider adaptation, and the connecting rod lower extreme links firmly with bottom plate one side.

5. The disintegration time limit apparatus for drug testing according to claim 4, wherein: and one side of the upper end of the connecting rod is fixedly provided with a positioning block provided with a screw hole, and a positioning bolt for limiting and fixing the medicine feeding unit is arranged on the screw hole.

6. The disintegration time limit apparatus for drug testing according to claim 5, wherein: the connecting rod vertical section upper portion be equipped with the apron of holding tank unit top adaptation, the apron, the holding tank that disintegrates all adopt transparent material, and apron, holding tank, the baffle of disintegrating are the bilayer structure of inside evacuation.