CN210541495U

CN210541495U - Photodynamic diagnosis and treatment integrated alimentary tract capsule endoscope

Info

Publication number: CN210541495U
Application number: CN201920957650.3U
Authority: CN
Inventors: 阴慧娟; 董晓曦; 李宏霄; 黄河; 张健; 李迎新
Original assignee: Institute of Biomedical Engineering of CAMS and PUMC
Current assignee: Institute of Biomedical Engineering of CAMS and PUMC
Priority date: 2019-06-25
Filing date: 2019-06-25
Publication date: 2020-05-19
Anticipated expiration: 2029-06-25

Abstract

The utility model provides an integrative alimentary canal capsule scope is diagnose to light power belongs to medical instrument technical field, integrative alimentary canal capsule scope is diagnose to light power includes camera system, control system, battery, communication system, camera system includes fluorescence camera, diagnosis LED light emitting source and treatment LED light emitting source. The utility model provides a photodynamic diagnosis and treatment integrated alimentary canal capsule endoscope only needs to improve the camera system of the existing magnetic control endoscope capsule system, changes the common optical camera system into the fluorescence camera system, does not need to expand extra equipment, and has strong adaptability; can realize the diagnosis and treatment of the internal cavities of the human body such as the digestive tract and the like, and realize the one-time completion of the photodynamic diagnosis and treatment.

Description

Photodynamic diagnosis and treatment integrated alimentary tract capsule endoscope

Technical Field

The utility model belongs to the technical field of medical instrument, especially, relate to an integrative alimentary canal capsule scope is diagnose to photodynamic.

Background

Photodynamic Diagnosis (PDD) is a novel diagnostic technique that utilizes selective enrichment of photosensitizing drugs at cancer cells; then, the cancer tissue is irradiated by exciting light to enable the enriched photosensitive medicine to generate fluorescence; the location and condition of the cancer can be judged by analyzing the intensity and distribution of the fluorescence. For example, the light sensitive drug ALA is a natural precursor of the heme pathway. Exogenous application of ALA leads to selective accumulation of the heme Precursor Protoporphyrin IX (PPIX) in cancer cells due to increased porphobilinogen deaminase activity and decreased iron chelatase activity. PPIX is a fluorescent substrate that fluoresces red under excitation by blue light (e.g., 385 nm). Research shows that in gastric cancer, the detection sensitivity of peritoneal metastasis can be obviously improved by using ALA-PDD technology. Furthermore, in glioblastoma, intraoperative ALA-induced fluorescence guidance can be used to completely ablate the tumor and improve progression-free survival. The greatest advantage of PDD is that tumor cells can be distinguished from normal cells by fluorescence, enabling the identification of flat lesions and small papillomas missing in white light endoscopy for treatment at an early stage of the tumor.

At present, the photodynamic diagnosis is mostly carried out by adopting a capsule endoscope, the capsule endoscope is an image system with the size and the shape similar to those of a capsule medicine, and a complete set of human digestive tract examination tool of an optical photographic system, a wireless communication system and a power supply system is integrated in the capsule endoscope. The capsule is swallowed by the subject and then moves in the gastrointestinal tract, and the inner wall of the gastrointestinal tract is photographed and checked along the way, and the image is sent to an external terminal. The doctor can locate and diagnose the lesion through the received image. Compared with the common endoscope, the capsule endoscope has less discomfort and higher patient dependence. However, the existing capsule endoscopy has single function, can only be used for shooting white light images in the alimentary canal, the diagnosis accuracy depends on the level of doctors, and the technology is difficult to find cancer focuses at early stage and even can not directly carry out PDT treatment. Several patents as disclosed in the prior art are all imaging type capsule endoscopes: US2005085696(a1) Medical appatatus, Medical appatatus guide system, capsule type Medical appatatus, and capsule type Medical appatatus, CN101123694A image pickup device and endoscope device using the same, CN202843565U a Medical magnetic capsule endoscope system.

Photodynamic therapy (PDT) is a new method for treating tumor diseases by using the photosensitive effect, and particularly, the tumor part is irradiated by light with specific wavelength, so that photosensitive drugs selectively gathered on tumor tissues are activated, and photochemical reaction is initiated to destroy the tumor. Wherein the photosensitive drug transfers energy to ambient oxygen to produce highly reactive singlet oxygen. The singlet oxygen can generate oxidation reaction with nearby biological macromolecules to generate cytotoxicity so as to kill tumor cells. PDT has the advantage over traditional tumor therapy of being able to deliver effective treatments with precise, targeted delivery and less side effects.

PDD and PDT can be used for accurately treating tumors in a combined manner, PDT is performed under the indication of fluorescence of PDD Photosensitizers (PS), and damage to surrounding normal tissues is minimized while tumors are sufficiently treated. Meanwhile, after the treatment is finished, the treatment effect can be judged by PDD, and secondary PDT treatment is carried out if necessary. The photodynamic diagnosis and treatment integrated technology is the development direction of accurate targeted tumor therapy.

And to the integrative technique of diagnosing of photodynamic, utility model patent that application number is CN201810137077.1 discloses a diagnose integrative cervical lesion photodynamic therapy system, and this system adopts coaxial light path to realize the real-time detection and the real-time controllable photodynamic treatment of focus shape, distribution, size, uses formation of image CCD probe to gather the focus image, and the computer carries out the edge detection of image, controls LED profile modeling array and sends the facula the same with the focus, realizes accurate treatment. The system has large volume and complex structure, is only suitable for superficial cavities (oral cavity, nasal cavity, vagina and the like) of a human body, and cannot realize photodynamic diagnosis and treatment integration on tumors (such as gastric cancer) in internal cavities of the human body.

SUMMERY OF THE UTILITY MODEL

In view of this, the present invention provides a small-sized photodynamic therapy and treatment integrated gastrointestinal capsule endoscope for gastrointestinal tumor.

The utility model provides an integrative alimentary canal capsule scope is diagnose to photodynamic, including camera system, control system, battery, communication system, camera system includes fluorescence camera, diagnosis LED luminescent light source and treatment LED luminescent light source.

Preferably, the camera system is positioned at one end of the alimentary canal capsule endoscope, and the diagnosis LED luminous light source and the treatment LED luminous light source are radially arranged at intervals by taking the fluorescent camera as a center.

Preferably, the adjacent diagnosis LED light-emitting light source and the adjacent treatment LED light-emitting light source are spaced at an angle of 40-50 degrees.

Preferably, the center wavelength of the diagnosis LED luminous light source is 390-410 nm.

Preferably, the central wavelength of the treatment LED light source is 620-640 nm.

Preferably, the diagnosis LED light source and the treatment LED light source have independent light emitting angles of 55-65 degrees.

Preferably, the surface of the diagnosis LED luminous light source and the surface of the treatment LED luminous light source are provided with secondary optical elements.

Preferably, the secondary optical element is a lens.

Preferably, a narrow-band filter is arranged on the fluorescent camera, the center wavelength of the narrow-band filter is 397-403 nm, and the bandwidth of the narrow-band filter is 30-100 nm; the minimum transmittance T of the narrow-band filter is more than 92%.

Preferably, the narrow-band filter is fixedly attached to the outer surface of the fluorescence camera.

The utility model has the advantages that: the utility model provides a pair of integrative alimentary canal capsule scope is diagnose to photodynamic, including camera system, control system, battery, communication system, camera system includes fluorescence camera, diagnosis LED luminescent light source and treatment LED luminescent light source. The utility model provides a photodynamic diagnosis and treatment integrated alimentary canal capsule endoscope only needs to improve the camera system of the existing magnetic control endoscope capsule system, changes the common optical camera system into the fluorescence camera system, does not need to expand extra equipment, and has strong adaptability; the diagnosis and treatment of the internal cavity of the human body such as the digestive tract can be integrated, and the photodynamic diagnosis and treatment can be completed at one time; the capsule endoscope for alimentary canal provided by the utility model has no pain for the patient during the treatment, and can greatly improve the treatment compliance of the patient; the utility model provides a alimentary canal capsule scope can realize that diagnosis/treatment go on repeatedly, can detect the treatment process of disease.

Drawings

FIG. 1 is a schematic view of a photodynamic diagnosis and treatment integrated digestive tract capsule endoscope;

FIG. 2 is a flow chart of the operation of the integrated digestive tract capsule endoscope for photodynamic diagnosis and treatment;

fig. 3 is a schematic view of a photodynamic diagnosis and treatment integrated alimentary tract capsule endoscope diagnosis and treatment.

Detailed Description

In the utility model, the photodynamic diagnosis and treatment integrated alimentary canal capsule endoscope is obtained by improving the camera system of the existing magnetic control endoscope capsule system; the utility model discloses in, the camera system of integrative alimentary canal capsule scope is diagnose to photodynamic includes fluorescence camera, diagnosis LED luminescent light source and treatment LED luminescent light source. In the present invention, the camera system is preferably located at one end of the gastrointestinal capsule endoscope. In the present invention, the camera system preferably includes a fluorescence camera, a plurality of diagnosis LED light sources and a plurality of treatment LED light sources; the diagnosis LED light source and the treatment LED light source are preferably arranged in a radial shape at intervals by taking a fluorescent camera as a center. In the utility model, the number of the diagnosis LED luminous light source and the treatment LED luminous light source is independently preferably 3-5, and more preferably 4; the interval angle between the adjacent diagnosis LED light-emitting light source and the adjacent treatment LED light-emitting light source is preferably 40-50 degrees, and more preferably 45 degrees.

The utility model discloses it is right diagnosis LED luminescent light source with treatment LED luminescent light source's central wavelength does not do the special limitation, and any LED luminescent light source's that can realize diagnosis and treatment central wavelength all can the utility model discloses in, diagnosis LED luminescent light source and treatment LED luminescent light source's central wavelength can match the upgrading according to the optical property of photosensitizer on the market. In the specific implementation process of the utility model, aiming at the existing photosensitizer medicine, the central wavelength of the diagnosis LED luminous light source is preferably 390-410 nm, and more preferably 400 nm; the central wavelength of the treatment LED light source is preferably 620-640 nm, and more preferably 630 nm.

In the present invention, the light emitting angles of the diagnosis LED light source and the treatment LED light source are preferably 55 ° to 65 °, and more preferably 60 °, respectively, and the preferred light emitting angles of the diagnosis LED light source and the treatment LED light source are realized by providing a secondary optical element on the surface. In the present invention, the secondary optical element is preferably a lens; the utility model discloses it is right the source and the specification of lens do not have special limitation the utility model discloses in the concrete implementation process, the preferred producer customization from LED luminescent light source of lens, the producer is when carrying out the LED encapsulation, directly goes out the lens of numerical value material at LED chip surface machining, makes LED luminescent light source's luminous angle is 55 ~ 65.

The utility model discloses in, the last preferred narrowband optical filter that is provided with of fluorescence camera, the preferred fixed laminating of narrowband optical filter in the surface of fluorescence camera. In the utility model, the central wavelength of the narrow-band filter is preferably 397-403 nm, and the bandwidth of the narrow-band filter is preferably 30-100 nm; the minimum transmittance T of the narrow band filter is preferably > 92%. The utility model discloses in, narrowband filter's effect is the exciting light of filtering photodynamic diagnosis PDD, and the fluorescence that only allows to arouse back production passes through to shoot by the camera.

The utility model discloses, it is right control system, battery and communication system in the integrative alimentary canal capsule scope is diagnose to light power do not have special restriction, adopt in the present alimentary canal capsule scope in this area control system, battery and communication system can. In the specific implementation process of the utility model, the existing alimentary canal capsule endoscope adopts the product of the magnetic control capsule gastroscope system robot of the company of Anhan science and technology (Wuhan) GmbH; the structure of the product and the product are described in detail in Chinese patent CN 201310275948.3. The technical scheme of the utility model is mainly aimed at the illuminating system and the image acquisition camera of the capsule endoscope, and does not relate to other parts of the alimentary tract capsule endoscope, such as a capsule shell, a photoelectric switch device, an image information processing circuit, a radio frequency transmission device, a power supply device, a magnetic field sensor, a small magnet and the like; the present invention is not limited to the above-described embodiments, and any structure or component capable of realizing the related function in the art may be used.

The technical solutions provided by the present invention are described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of the present invention.

Example 1

The LED fluorescent lamp comprises a camera system, a control system, a battery and a communication system, wherein the camera system comprises a fluorescent camera, a diagnosis LED light source and a treatment LED light source.

The specific structure is shown in fig. 1, wherein 1 is a diagnosis LED light source, 2 is a treatment LED light source, 3 is a fluorescence camera, 4 is a control system, 5 is a battery, and 6 is a communication system. The position relation of the fluorescent camera, the diagnosis LED light-emitting source and the treatment LED light-emitting source is shown on the right side of the figure 1, and the diagnosis LED light-emitting source and the treatment LED light-emitting source are radially arranged at intervals by taking the fluorescent camera as a center; the number of the diagnosis LED light-emitting sources and the number of the treatment LED light-emitting sources are both 4, the diagnosis LED light-emitting sources and the treatment LED light-emitting sources are arranged at intervals, and the interval angle is 45 degrees.

A fluorescent camera is arranged at the front end of the endoscope, a narrow-band filter with the central wavelength of 400nm is fixedly attached to the outer surface of the camera, and the bandwidth is 30 nm; minimum transmittance: t is greater than 92%; the narrow-band filter can filter out the excitation light of the PDD, only allows the fluorescence generated after excitation to pass through, and is shot by the camera.

The other parts of the structure control system, the battery and the communication system are as described in the Chinese patent CN 201310275948.3.

Example 2

The photodynamic diagnosis and treatment integrated alimentary canal capsule endoscope in the embodiment 1 is applied to perform photodynamic diagnosis and treatment.

Taking the diagnosis and treatment integrated process of gastric cancer as an example, the working flow is shown in fig. 2:

(1) patients with gastric cancer suspected to have food intake for at least 8 hours before treatment;

(2) injecting photosensitive drug (such as oxyphenirane, 5mg/kg body weight) to enrich the photosensitive drug in tumor tissue;

(3) the treatment capsule is taken by a patient with gastric cancer and swallowed by 1.5-2L of water;

(4) 1.5-2L of water can fill the stomach so as to smoothly complete diagnosis and treatment;

(5) the doctor turns on the PDD diagnosis LED and explores the stomach by using a magnetic control system;

(6) after finding the fluorescence enhanced region (tumor tissue), hovering the capsule;

(7) the diagnosis LED is turned off, and the PDT treatment LED is turned on to irradiate the focus (the power density is 20 mW/cm)²The irradiation time is 20-50 min), the treatment light and the enriched photosensitive drug generate photochemical reaction to generate singlet oxygen which is toxic to cells, so that the tumor tissue is killed in a targeted manner;

(8) after the treatment is finished, the power supply in the capsule is exhausted, and the capsule can be discharged out of the body through the small intestine, the large intestine and the anus within 1-2 days;

(9) after 1 treatment, the diagnosis and treatment integrated capsule can be used again to re-explore and treat the focus on a day to realize cure, and no tumor cells are found in tissue biopsy.

A schematic diagram of a photodynamic diagnosis and treatment integrated alimentary tract capsule endoscope diagnosis and treatment is shown in figure 3, wherein 1 is a PDD diagnosis LED light-emitting source; 2 is the fluorescence emitted by the tumor tissue; 3 is tumor tissue; and 4, a PDT treatment LED luminous light source.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, a plurality of modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims

1. A photodynamic diagnosis and treatment integrated alimentary canal capsule endoscope comprises a camera system, a control system, a battery and a communication system, and is characterized in that the camera system comprises a fluorescent camera, a diagnosis LED light source and a treatment LED light source.

2. The gastrointestinal capsule endoscope of claim 1, wherein the camera system is located at one end of the gastrointestinal capsule endoscope, and the diagnosis LED light source and the treatment LED light source are radially spaced apart from each other around a fluorescent camera.

3. The gastrointestinal capsule endoscope of claim 2, wherein the adjacent diagnosis LED light emitting sources and the treatment LED light emitting sources are spaced at an angle of 40-50 °.

4. The endoscopy of any one of claims 1 to 3, wherein the diagnostic LED light source has a center wavelength of 390 to 410 nm.

5. The gastrointestinal capsule endoscope according to any one of claims 1 to 3, wherein the center wavelength of the treatment LED light source is 620 to 640 nm.

6. The gastrointestinal capsule endoscopy of any one of claims 1 to 3, wherein the diagnosis LED luminescence light source and the treatment LED luminescence light source have an independent luminescence angle of 55 ° to 65 °.

7. The gastrointestinal capsule endoscope of claim 6, wherein secondary optical elements are arranged on the surface of the diagnosis LED luminous light source and the treatment LED luminous light source.

8. The gastrointestinal capsule endoscope of claim 7, wherein the secondary optical element is a lens.

9. The gastrointestinal capsule endoscope according to claim 1 or 2, wherein a narrow band filter is arranged on the fluorescent camera, the center wavelength of the narrow band filter is 397-403 nm, and the bandwidth of the narrow band filter is 30-100 nm; the minimum transmittance T of the narrow-band filter is more than 92%.

10. The endoscopy of claim 9, wherein the narrow band filter is fixedly attached to an outer surface of the fluorescence camera.