CN210447020U - A fingertip hemostix for glycated haemoglobin analysis appearance autoinjection - Google Patents
A fingertip hemostix for glycated haemoglobin analysis appearance autoinjection Download PDFInfo
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- CN210447020U CN210447020U CN201920712649.4U CN201920712649U CN210447020U CN 210447020 U CN210447020 U CN 210447020U CN 201920712649 U CN201920712649 U CN 201920712649U CN 210447020 U CN210447020 U CN 210447020U
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Abstract
The utility model discloses a fingertip hemostix for automatic sample introduction of a glycosylated hemoglobin analyzer, which comprises a blood sampling drainage needle, a tube body and a sealing cover arranged at the top end of the tube body, wherein a blood sampling passage, a blood chamber, a hemolysis chamber and a sample suction tube are arranged in the tube body; the blood sampling drainage needle penetrates through a blood sampling needle hole in the sealing cover and is embedded in a blood sampling passage, the upper end of the blood sampling passage is connected with the sealing cover, the lower end of the blood sampling passage is communicated with the blood chamber, a hemolysis chamber communicated with the blood chamber is arranged below the blood chamber, the top end of the hemolysis chamber is provided with a sample suction pipe which is connected with the sealing cover, and the sample suction pipe is positioned in the central shaft direction of the tube body; the sealed top of lid set up the introduction port, the introduction port is directly over the appearance pipe of inhaling, the autoinjection needle can puncture the introduction port and inhale the blood of getting in the blood dissolving room and detect. The utility model discloses a fingertip hemostix not only the blood sampling volume is few, can directly be used for the glycated haemoglobin analysis appearance to advance the appearance moreover, and convenient to use is simple.
Description
Technical Field
The utility model relates to the field of medical equipment, more specifically relates to a fingertip hemostix for glycated haemoglobin analysis appearance autoinjection.
Background
The glycosylated hemoglobin HbA1c measured by the glycosylated hemoglobin analyzer can reflect the average blood glucose level of a patient for about three or four months, the detection result is not influenced by whether the patient eats or drinks water before detection, and the glycosylated hemoglobin HbA c is a 'gold index' for diagnosing diabetes and evaluating the blood glucose control level and is widely applied to clinic. At present, a glycosylated hemoglobin analyzer generally adopts a conventional vacuum blood collection tube for sample injection, the blood collection quantity is large, and about 5mL of blood needs to be collected generally. But in practice, only 20-50 μ L of blood is sucked away during automatic sample injection of the instrument, so that excessive blood sampling is caused, and a large amount of biochemical pollution waste is left after the measurement is finished. Since HbA1c is a relative amount rather than a total amount, i.e., the ratio of glycated hemoglobin to the total amount of glycated and non-glycated hemoglobin, the measurement results are consistent between whole blood samples and those after appropriate dilution, and fingertip blood mixed with a large amount of other body fluids due to squeezing can be used for HbA1c measurement, and the amount of two drops of blood taken is sufficient for the test. Although the collection of the fingertip blood is more convenient than the collection of the venous blood and the blood collection amount is less, a hemostix which can adapt to automatic sample introduction and is used for HbA1c analysis on the fingertip blood is not available at the present stage, a doctor only can manually operate and process the fingertip blood, the operation is more complicated, the working efficiency is low, and the vacuum blood collection tube which is convenient for automatic sample introduction of an instrument is adopted in actual work to collect the venous blood to prepare the HbA1c instead of collecting the fingertip blood.
SUMMERY OF THE UTILITY MODEL
The utility model discloses it is great to the vacuum test tube blood sampling volume, can leave over after the survey a large amount of biochemical pollution discarded object and the ordinary hemostix fingertip blood of gathering can not with the not enough of instrument autoinjection, provide a fingertip hemostix for glycosylated hemoglobin analysis appearance autoinjection. The utility model discloses a fingertip hemostix can be used to gather the fingertip blood, and not only the blood sampling volume is few, has avoided leaving over a large amount of biochemical pollution discarded object, and comparatively environmental protection can be like conventional heparin tube in addition, arranges in on the glycated haemoglobin assay appearance, inhales the appearance by the automatic puncture of instrument, makes the fingertip blood sampling also can operate the computer and carry out full-automatic analysis, and convenient to use has improved the efficiency of doctor's inspection work.
The technical scheme of the utility model is that:
a fingertip hemostix for automatic sample introduction of a glycosylated hemoglobin analyzer comprises a blood sampling drainage needle, a tube body and a sealing cover arranged at the top end of the tube body, wherein a blood sampling passage, a blood chamber, a blood dissolving chamber and a sample suction tube are arranged in the tube body; the blood sampling drainage needle penetrates through a blood sampling needle hole in the sealing cover and is embedded in a blood sampling passage, the upper end of the blood sampling passage is connected with the sealing cover, the lower end of the blood sampling passage is communicated with the blood chamber, a hemolysis chamber communicated with the blood chamber is arranged below the blood chamber, the top end of the hemolysis chamber is provided with a sample suction pipe which is connected with the sealing cover, and the sample suction pipe is positioned in the central shaft direction of the tube body; the sealed top of lid set up the introduction port, the introduction port is directly over the appearance pipe of inhaling, the autoinjection needle can puncture the introduction port and inhale the blood of getting in the blood dissolving room and detect.
And an air guide capillary tube is further arranged at the inner top end of the tube body, one end of the air guide capillary tube is abutted against the sealing cover, and the other end of the air guide capillary tube is communicated with the upper part of the blood chamber. The air guide capillary has the function of ventilating to balance internal and external air pressure, and has no capillary effect on a whole blood sample due to hydrophobic interface, so that blood entering the blood chamber cannot automatically enter the air guide tube to cause blood overflow pollution. The air guide capillary is connected with the uppermost part of the blood chamber, and blood is almost filled in the blood chamber after blood collection, so that the blood collection amount is close to the volume of the blood chamber each time. The air guide capillary tube is of a snake-shaped bent structure, so that air resistance and liquid resistance can be increased, and the probability of blood overflow pollution is further reduced.
The sealing cover is provided with a vent hole which can be in butt joint with the air guide capillary tube, and the vent hole can be in butt joint with the air guide capillary tube by rotating the sealing cover. The vent hole is covered by the sealing gasket in the purchasing and selling transportation process and before use of the finished hemostix product as a product; when blood is collected, the vent hole is in butt joint with the air guide capillary tube.
The sealing cover comprises a sealing gasket and a sealing cap, and the sealing gasket is embedded between the sealing cap and the sealing pipe body and used for sealing the pipe body. The inboard 4 archs that evenly set up of sealing cap, body outside upper end set up 4 pits, pit position and size all with protruding phase-match, and protruding embedding pit in. Through 4 alignment location to protruding and pit, the sealed block rotates 90 degrees on the body, can make the air vent dock with the air guide capillary with sealed lid rotation.
The blood sampling drainage needle is a cylindrical puncture needle, and the needle point is a beveled plane. When in installation, the blood sampling tube is in butt joint with the blood sampling passage and is tightly clamped.
The length of the blood sampling drainage needle exposed outside the sealing cover is at least 2 mm.
The outer diameter of the blood sampling drainage needle is 0.5-2.5 mm, and the inner diameter of the blood sampling drainage needle is 0.1-2 mm.
The blood sampling passage is divided into an upper section and a lower section, and the diameter of the upper section (the part inserted into the blood sampling drainage needle) is the same as the outer diameter of the blood sampling drainage needle; the diameter of the lower section (the part without inserting the blood sampling drainage needle) is the same as the inner diameter of the blood sampling drainage needle. The blood sampling drainage needle is firmly embedded into the blood sampling passage and supported, and the blood sampling drainage needle is not loosened or sunk into the blood chamber under proper stress during blood sampling.
The blood chamber is communicated with the hemolysis chamber through a communicating capillary. The diameter of the communicating capillary tube is 0.1-1.2 mm. After the hemolytic agent is injected into the hemolytic chamber, the sealing cover is tightly covered, so long as the hemolytic agent does not enter the blood chamber if the hemolytic agent is shaken slightly or even turned upside down in the transportation process because of not too violent oscillation.
The external diameter of the pipe body is 13 mm. The tube body is consistent with a conventional vacuum blood collection tube, and can be directly used for puncture sample suction of an automatic sample injection needle of a glycosylated hemoglobin analyzer by being matched with a blood collection tube rack of the automatic sample injector of the glycosylated hemoglobin analyzer.
The tube body is made of hydrophobic plastic, the formed inner pipeline has no capillary effect on the whole blood sample (the whole blood sample cannot infiltrate the surface of the tube body), and the tube body is made by a 3D printing method. The hydrophobic plastic prevents the pre-loaded hemolysis agent from entering the airway capillary.
Preferably, the hydrophobic plastic is any one of terpolymer of acrylonitrile, butadiene and styrene, polylactic acid or light-cured resin.
The blood sampling drainage needle is made of metal with strong corrosion resistance. The blood sampling drainage needle is a drainage needle with a hydrophilic layer on the inner surface. The inner tube wall of the blood sampling drainage needle has capillary action on the whole blood sample (the whole blood sample can infiltrate the inner surface of the blood sampling drainage needle), so that the blood is automatically sucked.
Preferably, the blood sampling drainage needle is made of 304 stainless steel.
The blood sampling drainage needle is a drainage needle with a hydrophilic layer on the inner surface. The step of carrying out hydrophilic treatment on the inner surface of the blood sampling drainage needle comprises the following steps:
(1) preparation of electrolyte solution: weighing 6.8g of potassium dihydrogen phosphate, 7.1g of disodium hydrogen phosphate and 3.7g of potassium chloride, dissolving in 1L of ultrapure water, adding 0.02mL of HEDP commercial solution, uniformly stirring, ultrasonically degassing for 20min, adding 0.5mg of ground multi-layer graphene, and ultrasonically dispersing for 1 h.
(2) Electrolytic cell circuit connection: connecting two ends of a 316L stainless steel puncture drainage needle with insulating hoses respectively, wherein the insulating hose at one end is driven by a peristaltic pump to extend into an electrolytic cell, the insulating hose at the other end directly extends into the electrolytic cell, and after the peristaltic pump is started, electrolyte can be filled in the puncture drainage needle to form a part of the wall of the electrolytic cell container to form a working electrode; simultaneously immersing a calomel electrode (reference electrode) and a platinum electrode (auxiliary electrode) in an electrolytic cell to form a three-electrode system; connecting corresponding connecting wires of an electrochemical workstation to the puncture drainage needle electrode (working electrode), the calomel electrode (reference electrode) and the platinum electrode (auxiliary electrode) respectively to complete the connection of an electrolytic cell passage;
(3) reaction in an electrolytic cell: setting the electrochemical workstation as an anodic stripping voltammetry mode, wherein the electrolysis voltage is-0.2V, and the electrolysis time is 5 min. During electrolysis, the peristaltic pump keeps rotating at the rotating speed of 10 r/min. After the reaction, the puncture drainage needle 1 having the hydrophilic layer on the inner surface is obtained.
The HEDP commercial solution is purchased from Nanjing Narco water treatment technology GmbH, and has a mass concentration of 50%; multilayer graphene was purchased from Nanjing Xiancheng nanomaterial science and technology Limited; the other raw materials are all obtained in the market.
The hemolytic chamber is internally filled with hemolytic agent, and the hemolytic agent is injected from the sample suction pipe. The hemolyzing agent pre-dosed into the hemolyzing chamber can dilute the blood semi-quantitatively. The measurement result of HbA1c is that the glycosylated hemoglobin accounts for the proportion of total hemoglobin, the repeatability requirement on the blood dilution multiple is not high, and the requirement on the analysis precision of HbA1c can be met by semi-quantitative dilution.
The utility model discloses a fingertip hemostix is when taking a blood sample, and the fingertip upwards punctures the fingertip with blood sampling drainage needle one end, extrudes the blood and drips, and blood flows out behind the fingertip, and the fingertip is downward, and blood sampling drainage needle mouth upwards contacts the blood and drips, then the blood drips and gets into the blood room at blood sampling drainage needle's capillary action and the automatic blood sampling drainage needle that inhales under the synergism of the action of gravity of blood. The collected blood is filled in the blood collecting and drainage needle and then naturally enters the blood chamber under the action of gravity. The blood chamber is divided into 3 paths which are communicated with the atmosphere, namely a blood sampling passage-a blood sampling drainage needle; airway-vent; the capillary tube, the blood dissolving chamber and the sample sucking tube are communicated, so that the air pressure can be kept balanced, and the blood can smoothly enter the blood chamber under the action of gravity.
In the blood sampling process, the communicated capillary tube has no capillary action due to the hydrophobicity of a material interface, blood cannot automatically enter the blood dissolving chamber from the blood chamber, the sealing cover is rotated to enable the vent hole to be communicated and butted with the air guide capillary tube, the air guide capillary tube is communicated with the atmosphere, the bulge in the sealing cover cap is clamped into the concave pit on the outer wall of the blood sampler again for fixing, the blood sampler is slightly and lightly thrown, and the blood enters the blood dissolving chamber through the communicated capillary tube and is mixed with a pre-loaded hemolytic agent for testing.
The method comprises the following steps of placing a fingertip blood collector in a blood collecting pipe frame of a glycosylated hemoglobin analyzer, enabling an automatic sample injection needle of the analyzer to enter a sample suction pipe through a puncture sample injection port, and then sucking blood in a hemolysis chamber for detection and analysis.
Before the upper frame receives the sample, the inner side of the sealing cover cap is aligned and positioned with the concave pit of the tube wall of the blood collector, and the sealing cover cap is screwed to the position where the vent hole is in butt joint with the air guide capillary.
The utility model has the advantages that:
1. the utility model discloses an among the fingertip hemostix, the blood sampling drainage needle of blood sampling usefulness is a capillary, and the internal surface is hydrophilic and the internal diameter is 0.1 ~ 2mm, has the automatic capillary action of inhaling the appearance, and through the capillary action principle of blood sampling drainage needle, with the automatic blood chamber that inhales of fingertip blood, accomplish the collection of fingertip blood.
2. The utility model discloses a fingertip hemostix is earlier with blood collection to the blood room in, mix with the hemolytic agent in the reentrant hemolyzing room, avoided little and the relatively poor defect of homogeneity of fingertip blood sampling volume of raw blood. Because venous blood is big, and whole homogeneity is also good, and fingertip blood mixes a certain amount of other body fluids because of the extrusion, and the homogeneity is relatively poor, and the volume of taking a blood sample is very little, and the system that makes the air get into the instrument is easily vacuumed up to the introduction needle. Therefore, after blood collection is finished, the blood enters the hemolyzing chamber and is properly diluted by hemolytic agent, so that the uniformity is improved, the volume is increased, and the condition that the subsequent measurement is extremely adversely affected due to the fact that the sampling needle is sucked empty is avoided.
3. The utility model discloses a fingertip blood collector, blood sampling drainage needle have hydrophilic layer's drainage needle for the internal surface, have capillary action to whole blood sample, and its inner surface can be infiltrated to whole blood sample, is favorable to fingertip blood sample to inhale automatically. The tube body is made of hydrophobic plastic, the whole blood sample cannot infiltrate the surface of the tube body, and the formed internal pipeline has no capillary effect on the whole blood sample, so that the pre-filled hemolytic agent can be prevented from entering and blocking the air guide capillary.
4. The utility model discloses a fingertip hemostix not only can be used to gather the fingertip blood, the blood sampling volume is few, a large amount of biochemical pollution discarded object has been avoided leaving over, comparatively environmental protection, and the body adopts the design with the used same specification of conventional vacuum test tube of glycated haemoglobin analysis appearance, arrange it in on the glycated haemoglobin analysis appearance, can be like conventional test tube, the appearance is inhaled in the automatic puncture of instrument, make the fingertip blood sampling also can operate the computer and carry out full-automatic analysis, need not manual test, high durability and convenient use are simple, doctor work efficiency is improved.
Other features and advantages of the present invention will be described in detail in the detailed description which follows.
Drawings
The above and other objects, features and advantages of the present invention will become more apparent by describing in more detail exemplary embodiments thereof with reference to the attached drawings, in which like reference numerals generally represent like parts throughout the exemplary embodiments of the present invention.
Fig. 1 shows a schematic structural view of the blood sampling drainage needle of the present invention when inserted into a fingertip blood sampling device.
Fig. 2 shows a schematic structural view of the blood sampling drainage needle of the present invention when the fingertip blood sampling device is not inserted.
In the figure: 1. sealing gaskets; 2. an air guide capillary tube; 3. a sample suction pipe; 4. a blood collection pathway; 5. a blood chamber; 6. a communicating capillary tube; 7. a hemolyzing chamber; 8. a blood sampling drainage needle; 9. a vent hole; 10. sealing the cap; 11. a pipe body; 12. a sealing cover; 13. a sample inlet; 14. a blood sampling needle hole.
Fig. 3 shows a structure diagram of the blood sampling drainage needle of the utility model.
Detailed Description
Preferred embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. While the preferred embodiments of the present invention have been illustrated in the accompanying drawings, it is to be understood that the invention may be embodied in various forms and should not be limited to the embodiments set forth herein.
Example 1
Referring to fig. 1-2, a fingertip blood collector for automatic sample injection of a glycated hemoglobin analyzer comprises a blood collecting drainage needle 8, a tube 11 and a sealing cover 12 arranged at the top end of the tube 11, wherein a blood collecting passage 4, a blood chamber 5, a hemolysis chamber 7 and a sample sucking tube 3 are arranged in the tube 11; the blood sampling drainage needle 8 penetrates through a blood sampling needle hole 14 on a sealing cover 12 and is embedded in a blood sampling passage 4, the upper end of the blood sampling passage 4 is connected with the sealing cover 12, the lower end of the blood sampling passage 4 is communicated with a blood chamber 5, a hemolysis chamber 7 communicated with the blood chamber 5 is arranged below the blood chamber 5, a sample suction pipe 3 is arranged at the top end of the hemolysis chamber 7 and is connected with the sealing cover 12, and the sample suction pipe 3 is positioned in the central axis direction of a tube body 11; the top end of the sealing cover 12 is provided with a sample inlet 13, the sample inlet 13 is arranged right above the sample suction pipe 3, and the automatic sample injection needle can puncture the sample inlet 13 to suck the blood in the blood dissolving chamber 7 for detection.
The top still is equipped with air guide capillary 2 in body 11, air guide capillary 2 is snakelike bending structure, can increase air resistance and liquid resistance, further reduces the probability that blood spills over the pollution. One end of the air guide capillary 2 is propped against the sealing cover 12, and the other end is communicated with the upper part of the blood chamber 5. The air guide capillary tube 2 has the function of ventilating to balance internal and external air pressure, and has no capillary action on a whole blood sample due to hydrophobic interface, so that blood entering the blood chamber 5 cannot automatically enter the air guide tube 2 to cause blood overflow pollution. The airway capillary 2 is connected to the uppermost part of the blood chamber 5, and the blood chamber 5 is almost filled with blood after blood collection, so that the amount of blood collected at each time is close to the volume of the blood chamber 5.
The sealing cover 12 is provided with a vent hole 9 which can be in butt joint with the air guide capillary 2, and the vent hole 9 can be in butt joint with the air guide capillary 2 by rotating the sealing cover 12 so as to enable the air guide capillary 2 to be communicated with the atmosphere. During the purchase and sale transportation process and before the use of the finished product of the hemostix as a product, the sealing cover 12 is rotated to enable the vent hole 9 to be covered by the sealing gasket 1; when blood is collected, the vent hole 9 is in butt joint with the air guide capillary 2. The sealing cover 12 comprises a sealing gasket 1 and a sealing cap 10, and the sealing gasket 1 is embedded between the sealing cap 10 and the sealing pipe body 11. The inboard 4 archs that evenly set up of sealing cap 10, body 11 outside upper end set up 4 pits, pit position and size all with protruding phase-match, and in the protruding embedding pit. Through the alignment and positioning of 4 pairs of bulges and pits, the sealing cap 10 can be fixed on the tube body 11 after rotating for 90 degrees each time, after the sealing cap 12 rotates, the vent hole 9 can be butted with the air guide capillary 2, and the sealing gasket 1 in the sealing cap 12 can also cover the upper end opening of the air guide capillary 2.
The blood chamber 5 is communicated with the blood dissolving chamber 7 through a communicating capillary 6.
The tube body takes polylactic acid as a raw material, the formed internal pipeline has no capillary action on a whole blood sample, the whole blood sample cannot infiltrate the surface of the internal pipeline, and the tube body is manufactured by adopting a 3D printing method.
The blood sampling drainage needle 8 is made of metal with strong corrosion resistance. The blood sampling drainage needle 8 is a drainage needle with a hydrophilic layer on the inner surface. The interior of the drainage needle is subjected to surface hydrophilic treatment, the inner tube wall of the blood sampling drainage needle has a capillary effect on a whole blood sample, and the inner surface of the whole blood sample can be soaked. The hydrophobic plastic prevents the pre-loaded hemolysis agent from entering the airway capillary.
The hemolytic chamber is internally filled with hemolytic agent, and the hemolytic agent is injected from the sample suction pipe. The hemolyzing agent injected into the hemolyzing chamber 7 in advance in a predetermined amount can dilute the blood in a semi-quantitative manner. The measurement result of HbA1c is that the glycosylated hemoglobin accounts for the proportion of total hemoglobin, the repeatability requirement on the blood dilution multiple is not high, and the requirement on the analysis precision of HbA1c can be met by semi-quantitative dilution.
As shown in fig. 3, the blood sampling drainage needle 8 is a cylindrical puncture needle, and the needle tip is a bevel plane.
Example 2
The blood sampling drainage needle is made of 304 stainless steel, and the rest of the structure is the same as that of the embodiment 1.
Example 3
The diameter of the communicating capillary 6 is 0.5mm, and the rest of the structure is the same as that of the embodiment 1. The hemolyzing chamber 7 is filled with a hemolytic agent and then the sealing cap 12 is tightly closed, and the rest of the structure is the same as that of example 1. Slight shaking or even inversion during transport does not allow the hemolyzing agent to enter the blood chamber 5.
Example 4
The diameter of the communicating capillary 6 is 1.2mm, and the rest of the structure is the same as that of the embodiment 1. After the hemolyzing chamber 7 is filled with hemolytic agent, the sealing cover 12 is tightly covered. Slight shaking or even inversion during transport does not allow the hemolyzing agent to enter the blood chamber 5.
Example 5
The diameter of the communicating capillary 6 is 0.1mm, and the rest of the structure is the same as that of the embodiment 1. After the hemolyzing chamber 7 is filled with hemolytic agent, the sealing cover 12 is tightly covered. Slight shaking or even inversion during transport does not allow the hemolyzing agent to enter the blood chamber 5.
Example 6
The blood sampling drainage needle 8 is a cylindrical puncture needle, the needle point is a beveled plane, and the rest structures are the same as those of the embodiment 1. When in installation, the blood sampling tube is butted and clamped with the blood sampling passage 4. When blood is collected, the length of the blood collection drainage needle 8 exposed out of the sealing cover 12 is 2 mm.
Example 7
The outer diameter of the blood sampling drainage needle 8 is 0.5mm, the inner diameter is 0.1mm, and the rest structures are the same as those of the embodiment 1.
Example 8
The outer diameter of the blood sampling drainage needle 8 is 2.5mm, the inner diameter is 2mm, and the rest structures are the same as those of the embodiment 1.
Example 9
The blood sampling passage is divided into an upper section and a lower section, and the diameter of the upper section (the part inserted into the blood sampling drainage needle) is the same as the outer diameter of the blood sampling drainage needle; the diameter of the lower section (the part without inserting the blood sampling drainage needle) is the same as the inner diameter of the blood sampling drainage needle, so that the blood sampling drainage needle 8 is firmly embedded into the blood sampling passage 4 and supported, and the blood sampling drainage needle is not loosened or sunk into the blood chamber 5 under moderate stress during blood sampling. The blood sampling drainage needle 8 is butted and clamped with the blood sampling passage 4 when being installed. During blood collection, the length of the blood collection drainage needle 8 exposed out of the sealing cover 12 is 2mm, and the rest structures are the same as those of the embodiment 1.
Example 10
The outer diameter of the pipe body 11 is 13mm, and the rest of the structure is the same as that of the embodiment 1. The tube body 11 is consistent with a conventional vacuum blood collection tube, and can be directly used for puncturing and sample suction of an automatic sample injection needle of a glycosylated hemoglobin analyzer by being matched with a blood collection tube rack of the glycosylated hemoglobin analyzer.
Example 11
The pipe body is made of a terpolymer of acrylonitrile, butadiene and styrene by a 3D printing method, and the rest of the structure is the same as that of the embodiment 1. The obtained inner pipeline of the pipe body has no capillary action on the whole blood sample, and the whole blood sample cannot infiltrate the surface of the pipe body.
Example 12
The tube body is made of light-cured resin serving as a raw material by a 3D printing method, and the rest of the structure is the same as that of the embodiment 1. The obtained inner pipeline of the pipe body has no capillary action on the whole blood sample, and the whole blood sample cannot infiltrate the surface of the pipe body.
Example 13
According to the above embodiment, a specific fingertip blood collector used by a doctor takes blood directly for detection: a304 stainless steel blood collection and drainage needle 8 with the outer diameter of 1.81mm and the inner diameter of 1.45mm is used for collecting fingertip blood, and a tube body 11 which is made of terpolymer of acrylonitrile, butadiene and styrene and has the length of 75mm and the outer diameter of 13mm by a 3D printing method is used for collecting blood. The doctor inserts blood sampling drainage needle 8 in blood sampling passageway 4 through inserting sealed lid 12 earlier, makes blood sampling drainage needle 8 imbed blood sampling passageway 4 firmly and supported, and the moderate atress during the blood sampling can not make it become flexible or sink into blood chamber 5, and the length that blood sampling drainage needle 8 exposes outside sealed lid 12 is 2 mm. When blood is collected, the fingertip of a patient faces upwards, one end of the blood collection drainage needle 8 is used for pricking the fingertip, blood drops are squeezed out, after blood flows out of the fingertip, the fingertip faces downwards, the opening of the blood collection drainage needle 8 is upwards contacted with the blood drops, and then the blood drops automatically suck the blood collection drainage needle into the blood chamber 5 under the synergistic action of the capillary action of the blood collection drainage needle 8 and the gravity action of the blood. The collected blood is filled in the blood collecting and drainage needle 8, and then naturally enters the blood chamber 5 under the action of gravity, and the blood almost fills the blood chamber 5. When blood is collected, the blood chamber 5 is divided into 3 paths to be communicated with the atmosphere, namely a blood collection path 4-a blood collection drainage needle 8; the air duct 2 is a vent hole 9; the capillary 6, the blood dissolving chamber 7 and the sample sucking tube 3 are communicated, so that the air pressure can be kept balanced, and the blood can smoothly enter the blood chamber 5 under the action of gravity. After blood collection is completed, the sealing cover is screwed to the sealing position of the vent hole 9 covered by the sealing gasket 1, the vent hole 9 is communicated with the snake-shaped bent air guide capillary tube 2 with the inner diameter of 0.3mm, the air guide capillary tube 2 is communicated with the atmosphere, so that blood can conveniently enter the tube body under the capillary action and then is discharged outwards, positive pressure cannot be formed inside, the blood is resisted with the capillary action, and the bulge in the sealing cover cap is clamped into the pit on the outer wall of the blood collector again for fixation, the blood collector is swung by force for a plurality of times, so that the blood enters the hemolysis chamber 7 with the width of 8mm through the communication capillary tube 6 with the diameter of 0.5mm and is mixed with a preinstalled hemolyt. This is because the communicating capillary 6 has no capillary action due to the hydrophobic nature of the material interface when drawing blood, and blood does not automatically enter the hemolyzing chamber 7 from the blood chamber 5.
Before the upper frame receives the sample suction, the inner side bulge of the sealing cover cap is aligned and positioned with the pit of the tube wall of the blood collector, the sealing cover cap is screwed to the position where the air vent 9 is in butt joint with the air guide capillary 2, the fingertip blood collector is placed in the blood collecting tube frame of the glycosylated hemoglobin analyzer, the automatic sample injection needle of the analyzer enters the sample suction tube 3 with the diameter of 1.5mm through the puncture sample injection port 13, and then the blood in the blood dissolving chamber 7 is sucked for the detection and analysis of the analyzer.
The utility model discloses a fingertip hemostix not only can be used to gather the fingertip blood, the blood sampling volume is few, a large amount of biochemical pollution discarded object has been avoided leaving over, comparatively environmental protection, and the body adopts the design with the used same specification of conventional vacuum test tube of glycated haemoglobin analysis appearance, arrange it in on the glycated haemoglobin analysis appearance, can be like conventional test tube, the appearance is inhaled in the automatic puncture of instrument, make the fingertip blood sampling also can operate the computer and carry out full-automatic analysis, need not manual test, high durability and convenient use are simple, doctor work efficiency is improved.
The drainage needle with the hydrophilic layer in the embodiment is used for carrying out hydrophilic treatment on the inner surface of the blood sampling drainage needle, and comprises the following specific steps:
(1) preparation of electrolyte solution: weighing 6.8g of potassium dihydrogen phosphate, 7.1g of disodium hydrogen phosphate and 3.7g of potassium chloride, dissolving in 1L of ultrapure water, adding 0.02mL of HEDP commercial solution, uniformly stirring, ultrasonically degassing for 20min, adding 0.5mg of ground multi-layer graphene, and ultrasonically dispersing for 1 h.
(2) Electrolytic cell circuit connection: connecting two ends of a 316L stainless steel puncture drainage needle with insulating hoses respectively, wherein the insulating hose at one end is driven by a peristaltic pump to extend into an electrolytic cell, the insulating hose at the other end directly extends into the electrolytic cell, and after the peristaltic pump is started, electrolyte can be filled in the puncture drainage needle to form a part of the wall of the electrolytic cell container to form a working electrode; simultaneously immersing a calomel electrode (reference electrode) and a platinum electrode (auxiliary electrode) in an electrolytic cell to form a three-electrode system; connecting corresponding connecting wires of an electrochemical workstation to the puncture drainage needle electrode (working electrode), the calomel electrode (reference electrode) and the platinum electrode (auxiliary electrode) respectively to complete the connection of an electrolytic cell passage;
(3) reaction in an electrolytic cell: setting the electrochemical workstation as an anodic stripping voltammetry mode, wherein the electrolysis voltage is-0.2V, and the electrolysis time is 5 min. During electrolysis, the peristaltic pump keeps rotating at the rotating speed of 10 r/min. After the reaction, the puncture drainage needle with the hydrophilic layer on the inner surface is obtained.
The HEDP commercial solution is purchased from Nanjing Narco water treatment technology GmbH, and has a mass concentration of 50%; multilayer graphene was purchased from Nanjing Xiancheng nanomaterial science and technology Limited; the other raw materials are all obtained in the market.
While various embodiments of the present invention have been described above, the above description is intended to be illustrative, not exhaustive, and not limited to the disclosed embodiments. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments.
Claims (10)
1. The utility model provides a fingertip hemostix for glycated haemoglobin assay appearance autoinjection which characterized in that: comprises a blood sampling drainage needle (8), a tube body (11) and a sealing cover (12) arranged at the top end of the tube body (11), wherein a blood sampling passage (4), a blood chamber (5), a blood dissolving chamber (7) and a sample suction tube (3) are arranged in the tube body (11); the blood sampling drainage needle (8) penetrates through a blood sampling needle hole (14) in a sealing cover (12) and is embedded in a blood sampling passage (4), the upper end of the blood sampling passage (4) is connected with the sealing cover (12), the lower end of the blood sampling passage is communicated with a blood chamber (5), a hemolysis chamber (7) communicated with the blood chamber (5) is arranged below the blood chamber (5), a sample suction pipe (3) is arranged at the top end of the hemolysis chamber (7) and is connected with the sealing cover (12), and the sample suction pipe (3) is positioned in the central axis direction of a pipe body (11); the top end of the sealing cover (12) is provided with a sample inlet (13), and the sample inlet (13) is arranged right above the sample suction pipe (3).
2. The fingertip blood collector for glycated hemoglobin analyzer autosampler according to claim 1, characterized in that: an air guide capillary tube (2) is further arranged at the top end in the tube body (11), one end of the air guide capillary tube (2) is abutted against the sealing cover (12), and the other end of the air guide capillary tube is communicated with the upper part of the blood chamber (5); the air guide capillary (2) is of a snake-shaped bending structure.
3. The fingertip blood collector for glycated hemoglobin analyzer autosampler according to claim 1, characterized in that: the sealing cover (12) is provided with a vent hole (9) which can be in butt joint with the air guide capillary tube (2).
4. The fingertip blood collector for glycated hemoglobin analyzer autosampler according to claim 1, characterized in that: the sealing cover (12) comprises a sealing gasket (1) and a sealing cap (10), and the sealing gasket (1) is embedded between the sealing cap (10) and the sealing pipe body (11).
5. The fingertip blood collector for glycated hemoglobin analyzer autosampler according to claim 1, characterized in that: the blood sampling drainage needle (8) is a cylindrical puncture needle, and the needle point is a beveled plane.
6. The fingertip blood collector for glycated hemoglobin analyzer autosampler according to claim 1, characterized in that: the length of the blood sampling drainage needle (8) exposed out of the sealing cover (12) is at least 2 mm.
7. The fingertip blood collector for glycated hemoglobin analyzer autosampler according to claim 1, characterized in that: the outer diameter of the blood sampling drainage needle (8) is 0.5-2.5 mm, and the inner diameter is 0.1-2 mm.
8. The fingertip blood collector for glycated hemoglobin analyzer autosampler according to claim 1, characterized in that: the blood sampling passage (4) is divided into an upper section and a lower section, and the diameter of the upper section is the same as the outer diameter of the blood sampling drainage needle (8); the diameter of the lower section is the same as the inner diameter of the blood sampling drainage needle (8).
9. The fingertip blood collector for glycated hemoglobin analyzer autosampler according to claim 1, characterized in that: the blood chamber (5) is communicated with the blood dissolving chamber (7) through a communicating capillary tube (6); the diameter of the communicating capillary tube (6) is 0.1-1.2 mm.
10. The fingertip blood collector for glycated hemoglobin analyzer autosampler according to claim 1, characterized in that: the blood sampling drainage needle (8) is a drainage needle with a hydrophilic layer on the inner surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920712649.4U CN210447020U (en) | 2019-05-17 | 2019-05-17 | A fingertip hemostix for glycated haemoglobin analysis appearance autoinjection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920712649.4U CN210447020U (en) | 2019-05-17 | 2019-05-17 | A fingertip hemostix for glycated haemoglobin analysis appearance autoinjection |
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|---|---|
| CN210447020U true CN210447020U (en) | 2020-05-05 |
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| CN201920712649.4U Active CN210447020U (en) | 2019-05-17 | 2019-05-17 | A fingertip hemostix for glycated haemoglobin analysis appearance autoinjection |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110090028A (en) * | 2019-05-17 | 2019-08-06 | 深圳市凯特生物医疗电子科技有限公司 | A kind of hemostix at finger tip for glycolated hemoglobin analysis automatic sampling |
-
2019
- 2019-05-17 CN CN201920712649.4U patent/CN210447020U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110090028A (en) * | 2019-05-17 | 2019-08-06 | 深圳市凯特生物医疗电子科技有限公司 | A kind of hemostix at finger tip for glycolated hemoglobin analysis automatic sampling |
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