CN210037822U - High-flux automatic chromatography detection equipment - Google Patents
High-flux automatic chromatography detection equipment Download PDFInfo
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- CN210037822U CN210037822U CN201920559877.2U CN201920559877U CN210037822U CN 210037822 U CN210037822 U CN 210037822U CN 201920559877 U CN201920559877 U CN 201920559877U CN 210037822 U CN210037822 U CN 210037822U
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Abstract
The utility model discloses an automatic analytical check out test set of high flux, include: a chromatographic device; the test strip pushing device is arranged above the chromatographic device and used for driving the detection mechanism to slide along the outer wall of the liquid storage box, so that a sample pad of the test strip is contacted with sample liquid flowing to each detection channel of the reaction cavity; the switching driving device is used for driving the switching mechanism to move so as to enable the liquid storage tank to be communicated with or cut off each detection channel of the reaction cavity; the oscillation device is used for driving the chromatography device to vibrate; the code scanning device is used for acquiring the information of the identification code arranged on the detection mechanism; the image acquisition device is used for acquiring an image of the color development area on the test strip; and the control device is electrically connected with the test strip pushing device, the code scanning device, the image acquisition device, the switching driving device and the oscillating device respectively. The utility model discloses an equipment can realize automatic application of sample, and is automatic shake even, automated inspection, whole process need not manual operation, has improved work efficiency greatly.
Description
Technical Field
The utility model relates to a biochemistry detects technical field, has especially related to an automatic analytical examination equipment of high flux.
Background
Chromatography detection is an important on-site rapid detection form in recent years, and is popular in the fields of clinic, food safety, environmental detection and the like due to convenience and rapidness. At present, chromatography often requires the use of multiple test strips to perform multiple index tests on a single sample. In the detection process, the common method is to place the sample solution in a common cavity, then place the test strip in the cavity, and read the result at a specific time.
Nevertheless this application utility model people is realizing the utility model discloses the in-process discovers that above-mentioned technique has following technical problem at least:
and (I) the method is only suitable for one-step chromatography and cannot be compatible with a two-step method. And the detection process of the public cavity with high requirements on the environment can generate pollution, and detection items such as nucleic acid and the like cannot be met.
And (II) monitoring the reaction time by a user in the detection process, stopping the reaction at different time points according to different items, or entering the next reaction, and interpreting the analysis result in a short time. Such time requirements put high demands on the operator, are prone to errors when faced with multiple samples, and are also prone to missing time points, leading to inaccurate results.
And (III) the test strip can be read one by one usually, so that the timeliness of reading is influenced, and in order to improve the consistency of reaction time, a sample pad full of samples needs to be manually removed, so that the sample is easily polluted while the operation is inconvenient. And the residual sample liquid on the chromatographic membrane still makes the reaction time inconsistent, and the result accuracy is reduced.
SUMMERY OF THE UTILITY MODEL
In order to remedy the defects of the prior art, the utility model provides a high-throughput automatic analytical analysis detection device.
The utility model discloses the technical problem that will solve realizes through following technical scheme:
a high throughput automated analytical detection apparatus comprising:
the chromatographic device comprises a liquid storage tank, a reaction cavity, a switching mechanism and a detection mechanism; the liquid storage tank is used for containing sample liquid; the reaction cavity is arranged below the liquid storage tank and comprises at least two mutually independent detection channels; the switching mechanism is arranged between the liquid storage tank and the reaction cavity and is used for controlling the liquid storage tank to be communicated with or cut off from each detection channel of the reaction cavity; the detection mechanism comprises a shell and a plurality of mutually parallel test strips arranged in the shell; the detection mechanism is arranged above the reaction cavity and is in sliding connection with the liquid storage tank;
the test strip pushing device is arranged above the chromatographic device and used for driving the detection mechanism to slide along the outer wall of the liquid storage box, so that a sample pad of the test strip is contacted with sample liquid flowing to each detection channel of the reaction cavity;
the switching driving device is arranged on one side of the chromatographic device and used for driving the switching mechanism to move so as to enable the liquid storage tank to be communicated with or cut off each detection channel of the reaction cavity;
the oscillation device is connected with the chromatography device and is used for driving the chromatography device to vibrate;
the code scanning device is used for acquiring the information of the identification code arranged on the detection mechanism;
the image acquisition device is used for acquiring an image of the color development area on the test strip;
and the control device is electrically connected with the test strip pushing device, the code scanning device, the image acquisition device, the switching driving device and the oscillating device respectively.
Furthermore, a longitudinal partition plate is arranged in the reaction cavity, and the inner cavity of the reaction cavity is divided into a plurality of mutually independent detection channels by the longitudinal partition plate; the position of the top of the reaction cavity corresponding to each detection channel is provided with a test strip socket and a sample inlet, the position of each test strip socket corresponds to each test strip, and the sample inlet is communicated with the liquid storage box through the switching mechanism.
Furthermore, the switching mechanism comprises a sleeve fixedly arranged at the bottom in the liquid storage tank and a guide rod movably inserted in the sleeve; the sleeve is provided with a plurality of groups of first through holes which are arranged in an array and penetrate through the sleeve, and the guide rod is provided with a plurality of groups of second through holes which are arranged in an array and correspond to the first through holes; the guide rod is provided with a first position and a second position relative to the sleeve, and when the guide rod is positioned at the first position, the first through hole and the second through hole are mutually aligned and communicated to form a liquid channel so that the liquid storage tank is communicated with each detection channel of the reaction cavity; when the guide rod is located at the second position, the first through hole and the second through hole are mutually staggered and enable the first through hole to be closed, and therefore the liquid storage tank and each detection channel of the reaction cavity are cut off.
Furthermore, the guide rod is rotatably inserted into the sleeve, the first through hole and the second through hole are aligned and communicated with each other or staggered with each other when the guide rod rotates relative to the sleeve, the switching driving device is a rotating assembly, the rotating assembly is connected with one side of the guide rod, and the guide rod can rotate in the sleeve under the driving of the rotating assembly, so that the guide rod is switched between the first position and the second position.
Furthermore, a spring is arranged in the sleeve, one end of the spring is fixed with one side of the guide rod, the other end of the spring is fixed with one side of the sleeve, and the spring drives the guide rod to slide along the axial direction of the sleeve when compressed or reset, so that the first through hole and the second through hole are mutually aligned and communicated or mutually staggered; the switching driving device comprises a first push rod for pushing the guide rod and a first push rod driving mechanism for driving the first push rod to move, and the first push rod driving mechanism is electrically connected with the control device.
Further, the test paper strip pushing device comprises a second push rod for pushing the shell and a second push rod driving mechanism for driving the second push rod to move, and the second push rod driving mechanism is electrically connected with the control device.
Further, the image acquisition device comprises a camera and an LED lamp.
Further, the device comprises an incubation device, wherein the chromatography device is arranged in the incubation device, and the incubation device is electrically connected with the control device.
Further, the device also comprises a limiting device used for limiting the termination position of the movement of the shell.
Furthermore, two sides of the liquid storage tank are respectively provided with an L-shaped baffle extending towards the outer side direction of the liquid storage tank, a sliding groove is formed between the L-shaped baffle and the liquid storage tank, and a shell of the detection mechanism is slidably mounted in the sliding groove; the L-shaped baffle is provided with a limiting groove, the shell of the detection structure is provided with a buckle, and the limiting groove is connected with the buckle to limit the position of the test strip in the shell.
Furthermore, a sealing element for sealing the opening of the reaction cavity is arranged at the top of the reaction cavity; the sealing element comprises a sealing film for sealing the socket of the test strip, and the lower end of the shell of the detection mechanism is provided with a puncturing device for puncturing the sealing film.
Further, be equipped with two at least holding tanks in the casing, holding tank parallel arrangement each other, the test paper strip is arranged in corresponding holding tank, the sample pad of test paper strip stretches out and forms the extension outside the casing, be provided with the observation window that is used for observing test paper strip testing result on the casing.
Furthermore, the test strip is an immunochromatography test strip, the immunochromatography test strip comprises a bottom plate, a sample pad, a chromatographic membrane and a water absorption pad are sequentially lapped on one side of the bottom plate according to the chromatographic direction, and a detection line and a quality control line corresponding to the object to be detected are arranged on the chromatographic membrane; an antibody marker of the substance to be detected or an antigen marker of the substance to be detected is fixed in the detection channel of the reaction cavity.
Further, the antibody marker of the analyte is a block of an antibody-marker conjugate of the analyte; the antigen marker of the substance to be detected is a block of an antigen-carrier protein-marker conjugate of the substance to be detected; the detection line is coated with an antibody of an object to be detected or an antigen-carrier protein conjugate of the object to be detected, and the quality control line is coated with a goat anti-rabbit IgG antibody or a goat anti-mouse IgG antibody; the marker is colloidal gold.
Furthermore, the test strip socket, the sample inlet, the first through hole, the second through hole and the test strip are the same in number, and are all 4-8.
The utility model discloses following beneficial effect has:
the utility model discloses in, the setting is swept the sign indicating number that the sign indicating number device read detection mechanism on, controlling means is according to the sign indicating number, discernment test paper strip information, extract the concrete working parameter of test paper strip operation from the database, make chromatography check out test set accomplish sample liquid according to the information of test paper strip and release the reaction chamber from the liquid reserve tank, the even incubation that shakes of chromatography device, the test paper strip inserts in the reaction chamber in the chromatography device, a series of automatic control detection flows such as reading of testing result, make on-the-spot short-term test personnel need not to multiple different projects, different samples remember different time points respectively and operate, the real-time and the accuracy of error rate with having improved the result have been reduced by a wide margin, satisfy the intelligent of a key operation and experience. Meanwhile, a plurality of test strips can be read simultaneously, and the result accuracy is better.
The utility model discloses an equipment can realize automatic application of sample, and is automatic shake even, automated inspection, whole process need not manual operation, has improved work efficiency greatly.
The utility model discloses a check out test set simple structure, each device arrange compactness, occupation space are little, and convenient to carry does benefit to the miniaturization that realizes equipment, has very high popularization and application and worth.
The utility model discloses a set up switching mechanism between liquid reserve tank and reaction tank for control liquid reserve tank and each detection channel of reaction chamber are linked together or are stopped, the reaction chamber includes at least two mutually independent detection channels, make the sample liquid in the liquid reserve tank evenly distribute each detection channel in the reaction chamber in step, realize evenly distributing and adding the appearance volume, improved the accuracy of application of sample, and the sample liquid in each detection channel can be adjusted as required at any time, the switching mode is reliable, convenient operation; the single reaction of chromatography in each detection channel can meet the requirement on environment sensitive test, can avoid cross infection and ensure the accuracy of detection results; the detection of multiple target detection objects can be realized by one-time sample adding, the problems that sample liquid distribution is uneven and distribution is difficult to control in combined detection are solved, multiple detections can be simultaneously and stably carried out, high-flux detection is realized, the workload of detection personnel is effectively reduced, and the detection efficiency is improved.
The utility model discloses in, detection mechanism with liquid reserve tank sliding connection, detection mechanism along the liquid reserve tank outer wall reciprocates, makes the sample pad of test paper strip contacts or separates with the sample liquid that circulates among each detection passage of reaction chamber. Through the arrangement, the test strip can be detected by a two-step method, and if the sample liquid in the liquid storage tank needs to be uniformly mixed, the liquid storage tank can be manually shaken, so that the test strip cannot be polluted, the interference to adjacent reaction holes cannot be caused, liquid transferring equipment such as a liquid transferring gun is not needed, and the device has the characteristics of high sensitivity, high specificity, simplicity and convenience in use, low cost and the like.
Adopt the utility model discloses a detection that chromatography device goes on is gone on in a system that seals relatively, has also reduced the sample to a certain extent and has polluted and detect the possibility of polluting, has further improved the stability that detects, has also reduced manual operation error's hidden danger.
The utility model discloses in, according to the actual detection demand, can choose for use the test paper strip and the reaction tank combination that detect different materials, satisfy different demands.
The utility model discloses in, the casing is arranged in to the test paper strip for the pollution (gloves or hand) in the operator operation process are difficult to receive to test paper strip itself, and it is more convenient to operate.
Drawings
FIG. 1 is a block diagram of the present invention;
FIG. 2 is a structural view of the chromatography device of the present invention;
fig. 3 is a perspective view of the switching mechanism of the present invention;
fig. 4 is another perspective view of the switching mechanism of the present invention.
In the figure: 1. chromatography device, 2, test paper strip pusher, 3, switching drive arrangement, 4, vibrate the device, 5, image acquisition device, 6, liquid reserve tank, 7, reaction chamber, 8, sleeve, 9, guide arm, 10, first through-hole, 11, second through-hole, 12, detection mechanism, 13, introduction port, 14, test paper strip socket, 15, observation window, 16, L shape baffle, 17, spacing groove, 18, buckle, 19, spring.
Detailed Description
The utility model provides a high flux automation chromatography check out test set, includes chromatography device, test paper strip pusher, switches drive arrangement, vibration device, sweeps a yard device, image acquisition device and controlling means, test paper strip pusher, sweep a yard device, image acquisition device, switch drive arrangement, vibration device respectively with the controlling means electricity is connected.
The chromatography device comprises a liquid storage tank, a reaction cavity, a switching mechanism and a detection mechanism.
The liquid storage tank is used for containing sample liquid. The top of the liquid storage tank is provided with a liquid injection port which is sealed by a cover body.
The reaction cavity is arranged below the liquid storage tank and comprises at least two mutually independent detection channels.
The utility model discloses do not do the particular limitation to the quantity of test channel, the needs that the skilled person in the art can carry out the flexibility according to actual detection set up, as preferred, the quantity of test channel can be 2-8, can be for example 6, 7, 8.
Specifically, a longitudinal partition plate is arranged in the reaction cavity, and the inner cavity of the reaction cavity is divided into a plurality of mutually independent detection channels by the longitudinal partition plate; the position of the top of the reaction cavity corresponding to each detection channel is provided with a test strip socket and a sample inlet, the position of each test strip socket corresponds to each test strip, and the sample inlet is communicated with the liquid storage box through the switching mechanism.
The reaction cavity is detachably connected with the liquid storage tank. The present invention is not limited to the specific detachable connection, and can be implemented by conventional methods in the prior art, which are well known to those skilled in the art.
The switching mechanism is arranged between the liquid storage tank and the reaction cavity and used for controlling the liquid storage tank to be communicated with or cut off from each detection channel of the reaction cavity.
The switching mechanism comprises a sleeve fixedly arranged at the bottom in the liquid storage tank and a guide rod movably inserted in the sleeve; the sleeve is provided with a plurality of groups of first through holes which are arranged in an array and penetrate through the sleeve, and the guide rod is provided with a plurality of groups of second through holes which are arranged in an array and correspond to the first through holes; the guide rod is provided with a first position and a second position relative to the sleeve, and when the guide rod is positioned at the first position, the first through hole and the second through hole are mutually aligned and communicated to form a liquid channel so that the liquid storage tank is communicated with each detection channel of the reaction cavity; when the guide rod is located at the second position, the first through hole and the second through hole are mutually staggered and enable the first through hole to be closed, and therefore the liquid storage tank and each detection channel of the reaction cavity are cut off.
The first through holes are arrayed along the length direction of the sleeve, and the second through holes are arrayed along the length direction of the guide rod.
The utility model discloses do not specifically prescribe the array arrangement mode of first through-hole and second through-hole, as the example, first through-hole can set up to one row, also can set up to two rows.
Preferably, referring to fig. 3, the guide rod is rotatably inserted into the sleeve, and when the guide rod rotates relative to the sleeve, the first through hole and the second through hole are aligned with each other or staggered with each other.
More preferably, referring to fig. 4, a spring is disposed in the sleeve, one end of the spring is fixed to one side of the guide rod, and the other end of the spring is fixed to one side of the sleeve, so that the guide rod is driven to slide along the axial direction of the sleeve when the spring is compressed or reset, and the first through hole and the second through hole are aligned with each other or staggered with each other.
The number of the groups of the first through holes and the second through holes is the same, and the number of the groups of the first through holes and the second through holes is determined according to the number of the detection channels in the reaction cavity.
The position of each sample inlet corresponds to the first through hole. It can be understood that the bottom of the liquid storage tank is the bottom of the sleeve, and the sample liquid placed in the liquid storage tank enters the detection channel through the relative movement of the sleeve and the guide rod.
The utility model discloses in, adopt this kind of switching mechanism for in sample liquid in the liquid reserve tank can synchronous evenly distributed each detection channel in the reaction chamber, realize average distribution and add the appearance volume, improved the accuracy of application of sample, the sample liquid in each detection channel can be adjusted as required at any time in addition, the switching mode is reliable, convenient operation.
The detection mechanism comprises a shell and a plurality of mutually parallel test strips arranged in the shell. The utility model discloses in, not specifically inject the placing means between casing and the test paper strip, as long as make the test paper strip easily fixed with remove out the casing can, the technical staff in the field can set for according to actual need. Preferably, be equipped with two at least holding tanks in the casing, holding tank parallel arrangement each other, the test paper strip is arranged in corresponding holding tank, the sample pad of test paper strip stretches out and forms the extension outside the casing.
And the shell is provided with an observation window for observing the detection result of the test strip. In order to improve the leakproofness, the observation window is embedded and is provided with a transparent plate.
The housing may also be transparent, in which case no additional viewing window is required.
The utility model discloses in, do not do the particular limitation to the quantity of test paper strip in the casing, the needs that the skilled person in the art can carry out the flexibility according to actual detection set up, as preferred, the quantity of test paper strip can be 4-8, can be for example 6, 7, 8.
Detection mechanism locates the reaction chamber top, detection mechanism with liquid reserve tank sliding connection, detection mechanism along the liquid reserve tank outer wall reciprocates for the sample pad of test paper strip contacts or separates with the sample liquid that circulates to each detection channel in the reaction chamber.
The utility model discloses in, still include stop device for the restriction the termination point of casing motion. Through setting up stop device for the test paper strip in the casing contacts with the sample liquid in the test channel and takes place immunoreaction, and the casing is fixed. Through the arrangement, the test strip in the shell can not be excessively pushed into the detection channel of the reaction cavity to cause the test strip to be broken, and the shell can not move upwards to separate the test strip in the shell from the sample liquid in the detection channel during detection to cause the immune reaction to stop.
The limiting device is preferably of a clamping groove structure. Specifically, two sides of the liquid storage tank are respectively provided with an L-shaped baffle extending towards the outer side of the liquid storage tank, a sliding groove is formed between the L-shaped baffle and the liquid storage tank, and a shell of the detection mechanism is slidably mounted in the sliding groove; the L-shaped baffle is provided with a limiting groove, the shell of the detection structure is provided with a buckle, and the limiting groove is connected with the buckle to limit the position of the test strip so as to limit the shell to continuously slide towards the reaction cavity.
The utility model discloses in, the top of reaction chamber is equipped with and is used for sealing reaction chamber open-ended sealing member for the inside space of sealed reaction chamber does not contact with the external world.
The sealing element comprises a sealing film for sealing the socket of the test strip, and the lower end of the shell of the detection mechanism is provided with a puncturing device for puncturing the sealing film.
It will be appreciated that the piercing means extends from the lower end of the housing to form a projection extending beyond the housing.
In the present invention, the sealing film should be selected to have a certain sealing property for the preservation solution, and a penetrable film material that is easily punctured by a sharp substance, typically but not limited to, such as tin foil or aluminum foil.
The utility model discloses in, do not do the special limitation to the puncture device, as long as guarantee with the test paper strip when inserting the test paper strip inserted hole, can puncture the seal membrane can. In a preferred embodiment, the port of the puncturing device is serrated to enable puncturing of the sealing membrane. As another preferred embodiment, the puncturing means comprises a plurality of puncturing members capable of puncturing the sealing membrane, the puncturing members preferably being sharp punctures.
The utility model provides a test paper strip socket adopts the sealed mode of pricking easily sealed, and when the detection mechanism casing slided downwards, the puncture device that the casing lower extreme set up punctures the seal membrane for in advance fixed marker can be better save among each detection channel in the reaction chamber, guarantee testing result's accuracy.
The sealing piece is arranged outside the sample inlet in a covering mode, and during detection, the sealing piece can be taken away firstly, and then the reaction cavity is connected to the lower portion of the liquid storage box.
The test strip pusher is arranged above the chromatographic device and used for driving the detection mechanism to slide along the outer wall of the liquid storage box, so that the sample pad of the test strip is in contact with the sample liquid circulating to each detection channel of the reaction cavity.
The utility model discloses in, test paper strip pusher is including being used for promoting the second push rod of casing, be used for the drive the second push rod actuating mechanism that the second push rod removed, second push rod actuating mechanism with the controlling means electricity is connected. Wherein the second push rod driving mechanism includes but is not limited to a solenoid valve, a stepping motor and a servo motor. It is understood that the test strip pushing device includes, but is not limited to, the above-mentioned structures, and other structures that are not listed in this embodiment but are well known to those skilled in the art may be adopted, as long as the effect of driving the detection mechanism to slide along the outer wall of the reservoir is achieved.
The switching driving device is arranged on one side of the chromatographic device and used for driving the switching mechanism to move so as to enable the liquid storage tank to be communicated with or cut off each detection channel of the reaction cavity.
The structure of the switching driving device is set according to the structure of the switching mechanism, and the effect that the switching mechanism is driven to move so that the liquid storage tank is communicated with or cut off each detection channel of the reaction cavity can be achieved.
Specifically, in the switching mechanism, the guide rod is rotatably inserted into the sleeve, when the guide rod rotates relative to the sleeve to enable the first through hole and the second through hole to be aligned and communicated with each other or to be staggered with each other, the switching driving device is a rotating assembly, the rotating assembly is connected with one side of the guide rod, and the guide rod can rotate in the sleeve under the driving of the rotating assembly, so that the guide rod is switched between the first position and the second position.
In the switching mechanism, a spring is arranged in the sleeve, one end of the spring is fixed to one side of the guide rod, the other end of the spring is fixed to one side of the sleeve, the spring drives the guide rod to slide along the axis direction of the sleeve when compressed or reset, so that the first through hole and the second through hole are aligned and communicated with each other or staggered with each other, the switching driving device comprises a first push rod for pushing the guide rod and a first push rod driving mechanism for driving the first push rod to move, and the first push rod driving mechanism is electrically connected with the control device. Wherein the first push rod driving mechanism includes but is not limited to a solenoid valve, a stepping motor and a servo motor.
The oscillation device is connected with the chromatography device and used for driving the chromatography device to vibrate.
The utility model discloses in, through setting up vibrating device, can make fixed reagent and the sample liquid misce bene of circulation to in the reaction chamber, detectivity is high, and the uniformity is good, and detection effect is good.
The utility model discloses in, do not do specifically and restrict oscillation device's structure, as long as the realization will fixed reagent in the reaction chamber with circulate to the reaction chamber in the sample liquid misce bene can, the technical staff in the field can adopt prior art's existing structure wantonly. Preferably, the chromatography device is arranged on the oscillation mechanism and used for driving the chromatography device to vibrate. Vibrate the mechanism and be general standard component or the part that technical staff in the field knows, its structure and principle all are this technical staff all can learn through the technical manual or learn through conventional experimental method, the utility model discloses do not do the restriction to the concrete structure that vibrates the mechanism, technical staff in the field can adopt current structure to realize. As an example, vibrate the mechanism including vibrating the tray, chromatography device arranges in on the vibration tray, vibrate the tray below and be connected with the shock motor, vibrate the motor with controlling means electricity is connected.
It should be noted that, the utility model provides a motion trail of vibrating mechanism can be for the straight line, also can be circular, vibrates the mechanism and makes the chromatography device of arranging on vibrating mechanism in realize vibrate from top to bottom, control and vibrate, vibrate around, or the commentaries on classics ring vibrates.
The code scanning device is used for collecting information of the identification codes arranged on the detection mechanism.
The utility model discloses in, be provided with the identification code on the detection mechanism, the identification code can be the one-dimensional code, also can be the two-dimensional code, but is not limited to this.
It can be understood that the utility model discloses in, locate an identification code of a plurality of test paper strip sharing in the casing.
The code scanning device comprises a support and a scanning probe arranged on the support, wherein the scanning probe is a one-dimensional or two-dimensional scanner.
The utility model discloses in, be provided with the identification code on the test paper strip, sweep the sign indicating number device and be used for reading the structural identification code that detects to supply the information of controlling means discernment test paper strip with the controlling means communication, so that transfer relevant processing control parameter from the product code database, if locate a plurality of test paper strips on the casing carry out time, the oscillation device's movement time, incubation time and temperature etc. that immunoreaction.
The utility model discloses in, sweep a yard device through the setting and read test paper strip identification code, controlling means is according to the identification code, and identification test paper strip information draws the concrete working parameter of test paper strip operation from the database for a series of automatic control detection flow are accomplished according to the information of test paper strip to chromatography check out test set, make the process of detection intelligent completely.
The image acquisition device is used for acquiring images of the color development areas on the test strip.
Image acquisition device can adopt the known structure that multiple common being used for of prior art disclosure was gathered and was saved the image, image acquisition device includes camera and LED lamp. During operation, the LED lamp is lighted to check out test set, starts the camera and shoots the test paper strip to transmit to controlling means and handle, and upload the processing result to outside mobile terminal. The camera generally comprises a lens and an image acquisition chip, wherein the lens and the image acquisition chip are mutually matched and are used for acquiring an image of a color development area on the test strip; more preferably, the image acquisition chip is a CCD image sensor. The LED lamp can be utilized for supplementing light to provide sufficient light source for image recognition of the camera so as to improve the image recognition effect.
In the present invention, the number of the cameras and the LED lamps is not particularly limited, and preferably, the number of the cameras is 1 to 8, more preferably 2 to 6, and the number of the LED lamps is 1 to 16.
The control device controls the test strip pushing device, the code scanning device, the image acquisition device, the switching driving device and the oscillation device to operate. The control device is the part that technical personnel in this field know, and its structure and principle all are this technical personnel and all can learn through the technical manual or learn through conventional experimental method, and technical personnel in this field can set up according to actual need, the utility model discloses do not restrict control device's specific structure.
The utility model discloses a chromatography check out test set is used for immunodetection, the test paper strip is immunochromatography test paper strip.
The utility model discloses a chromatography detects when being used for immunodetection, can be used for the immunochromatography of one-step process, also can be used for the immunochromatography of two-step process.
When the chromatographic detection of the utility model is used for immunochromatography of a one-step method, the test strip comprises a bottom plate, a sample pad, a combination pad, a chromatographic membrane and a water absorption pad are sequentially lapped on one side of the bottom plate according to the chromatographic direction, and an antibody marker of an object to be detected or an antigen marker of the object to be detected is fixed on the combination pad; and the chromatographic membrane is provided with a detection line and a quality control line corresponding to the object to be detected.
When the utility model discloses a chromatography detects when establishing the immunochromatography that is used for the two-step method, immunochromatography test paper strip includes the bottom plate there are sample pad, chromatographic membrane, the pad that absorbs water according to the chromatography direction overlap joint in proper order on bottom plate one side, be equipped with detection line and the quality control line that corresponds with the determinand on the chromatographic membrane. The immunochromatography test strip comprises a bottom plate, a sample pad, a chromatographic membrane and a water absorption pad, wherein the sample pad is arranged on one side of the bottom plate, the water absorption pad is arranged on the other side of the bottom plate, the chromatographic membrane is arranged between the sample pad and the water absorption pad, the adjacent sample pad and the chromatographic membrane are connected in an overlapped mode at the joint, the chromatographic membrane and the water absorption pad are connected in an overlapped mode at the joint, a detection line and a quality control line are arranged in the middle of the chromatographic membrane, the detection line is close to the sample pad, and the sample pad of the test strip extends out of a shell to; an antibody marker of the substance to be detected or an antigen marker of the substance to be detected is fixed in the detection channel of the reaction cavity.
The immunochromatography of the two-step method arranges the marker conjugate coated in the existing bonding pad in each detection channel of the reaction cavity, so that the marker conjugate can react with the sample solution to be detected more fully, the defects of incomplete reaction, low efficiency and the like on the bonding pad in the traditional immunochromatography test strip are overcome, the object to be detected and the marker conjugate can react thoroughly in a homogeneous system, and the sensitivity is improved.
The antibody marker of the substance to be detected is a block of an antibody-marker conjugate of the substance to be detected; the antigen marker of the substance to be detected is a block of an antigen-carrier protein-marker conjugate of the substance to be detected; the detection line is coated with an antibody of an object to be detected or an antigen-carrier protein conjugate of the object to be detected, and the quality control line is coated with a goat anti-rabbit IgG antibody or a goat anti-mouse IgG antibody; the label is a substance that can be used to identify and detect the collected signal, such as, but not limited to, colloidal gold.
The test strip socket, the sample inlet, the first through hole, the second through hole and the test strip are the same in number and are 4-8.
As a further improvement, the device further comprises an incubation device, the chromatography device is arranged in the incubation device, and the incubation device is electrically connected with the control device. The utility model discloses in, through setting up incubation device, for the test paper strip provides suitable incubation temperature, promote molecular motion speed, make the reactant fully contact to shorten immunoreaction and reach balanced time, thereby guarantee enough high sensitivity.
The temperature of the incubation device ranges from 4 ℃ to 120 ℃.
The incubation device may adopt a structure known in the art, and by way of example, the incubation device includes an incubation well and a temperature control electronic module located at the bottom of the incubation well for controlling the temperature of the incubation well.
Taking the two-step method for immunodetection as an example, the detection method of the utility model is as follows: collecting a sample, processing the sample to obtain a sample liquid, putting the sample liquid into a liquid storage box, and placing a chromatography device on a vibration device; the code scanning device reads the identification code arranged on the test strip and transmits the identification code to the control device; the control device controls the switching driving device to work, so that the switching mechanism moves to further enable the liquid storage tank to be communicated with each detection channel of the reaction cavity, sample liquid in the liquid storage tank flows into each detection channel through a sample inlet on the reaction cavity, and after a preset time, the switching driving device moves to drive the switching mechanism to move to enable the liquid storage tank and each detection channel of the reaction cavity to be cut off; according to the temperature requirement of each test strip, carrying out incubation on the test strips through an incubation device; the control device controls the oscillation device to work, so that an object to be detected in a sample liquid is fully and uniformly mixed with an antibody marker of the fixed object to be detected in the detection channel or an antigen marker of the object to be detected to react, after the reaction is carried out for a preset time, the control device controls the test strip pushing device to work, the assembled detection mechanism slides downwards, the puncture device arranged at the lower end of the shell in the detection mechanism punctures the seal membrane, so that the test strip is inserted into the test strip jack on the reaction cavity, the sample pad of the test strip is contacted with the sample liquid in the detection channel to carry out immunochromatography reaction, after the chromatography reaction is carried out for a preset time, the image acquisition device works to acquire color band information presented on the test strip, and the result is fed back to the control.
The present invention will be described in detail with reference to the following examples, which are only preferred embodiments of the present invention and are not intended to limit the present invention.
Example 1
The utility model provides a high flux automation chromatography check out test set, includes chromatography device, test paper strip pusher, switches drive arrangement, vibration device, sweeps a yard device, image acquisition device and controlling means, test paper strip pusher, sweep a yard device, image acquisition device, switch drive arrangement, vibration device respectively with the controlling means electricity is connected.
The chromatography device comprises a liquid storage tank, a reaction cavity, a switching mechanism, a detection mechanism, a limiting device and a sealing element; the liquid storage tank is used for containing sample liquid; the top of the liquid storage tank is provided with a liquid injection port which is sealed by a cover body; the reaction cavity is arranged below the liquid storage tank, a longitudinal partition plate is arranged in the reaction cavity, and the inner cavity of the reaction cavity is divided into 6 mutually independent detection channels by the longitudinal partition plate; the top of the reaction cavity is provided with a test strip jack and a sample inlet at the position corresponding to each detection channel, the position of each test strip jack corresponds to each test strip, and the sample inlet is communicated with the liquid storage box through a switching mechanism; the switching mechanism is arranged between the liquid storage tank and the reaction cavity and is used for controlling the liquid storage tank to be communicated with or cut off from each detection channel of the reaction cavity; the switching mechanism comprises a sleeve fixedly arranged at the bottom in the liquid storage tank and a guide rod which is rotatably inserted in the sleeve; the sleeve is provided with 6 groups of first through holes which are arranged in an array and penetrate through the sleeve, and the guide rod is provided with 6 groups of second through holes which are arranged in an array and correspond to the first through holes; when the guide rod rotates, the guide rod has a first position and a second position relative to the sleeve, and when the guide rod is located at the first position, the first through hole and the second through hole are mutually aligned and communicated to form a liquid channel so that the liquid storage tank is communicated with each detection channel of the reaction cavity; when the guide rod is located at the second position, the first through hole and the second through hole are mutually staggered and close the first through hole, so that the liquid storage tank and each detection channel of the reaction cavity are cut off; the detection mechanism comprises a shell, 6 accommodating grooves are formed in the shell and are arranged in parallel, the test strip is arranged in the corresponding accommodating groove, a sample pad of the test strip extends out of the shell to form a protruding part, and an observation window for observing the detection result of the test strip is arranged on the shell; the detection mechanism is arranged above the reaction cavity, is connected with the liquid storage box in a sliding manner and moves up and down along the outer wall of the liquid storage box, so that a sample pad of the test strip is contacted with or separated from sample liquid flowing into each detection channel of the reaction cavity; the test strip is an immunochromatography test strip, the immunochromatography test strip comprises a bottom plate, a sample pad, a chromatographic membrane and a water absorption pad are sequentially lapped on one side of the bottom plate according to the chromatographic direction, and a detection line and a quality control line corresponding to an object to be detected are arranged on the chromatographic membrane; an antibody marker of the substance to be detected or an antigen marker of the substance to be detected is fixed in the detection channel of the reaction cavity; the antibody marker of the substance to be detected is a block of an antibody-marker conjugate of the substance to be detected; the antigen marker of the substance to be detected is a block of an antigen-carrier protein-marker conjugate of the substance to be detected; the detection line is coated with an antibody of an object to be detected or an antigen-carrier protein conjugate of the object to be detected, and the quality control line is coated with a goat anti-rabbit IgG antibody or a goat anti-mouse IgG antibody; the marker is colloidal gold; the limiting device is used for limiting the position of the shell; the detection mechanism comprises a liquid storage tank, a shell, a detection mechanism and a detection mechanism, wherein L-shaped baffles extending towards the outer side of the liquid storage tank are arranged on two sides of the liquid storage tank, a sliding groove is formed between each L-shaped baffle and the liquid storage tank, and the shell of the detection mechanism is slidably mounted in the sliding groove; a limiting groove is formed in the L-shaped baffle, a buckle is arranged on the shell of the detection structure, and the limiting groove is connected with the buckle to limit the position of the test strip in the shell; the sealing element is arranged at the top of the reaction cavity and used for sealing the opening of the reaction cavity; the sealing element comprises a sealing film for sealing the socket of the test strip, and a puncturing device for puncturing the sealing film is arranged at the lower end of the shell of the detection mechanism; the lancing device includes a plurality of lancing members, which are sharp lancets.
The test strip pusher is arranged above the chromatographic device and used for driving the detection mechanism to slide along the outer wall of the liquid storage box, so that the sample pad of the test strip is in contact with the sample liquid circulating to each detection channel of the reaction cavity.
The switching driving device is arranged on one side of the chromatographic device and used for driving the switching mechanism to move so as to enable the liquid storage tank to be communicated with or cut off each detection channel of the reaction cavity; the switching driving device is a rotating assembly, the rotating assembly is connected with one side of the guide rod, and the guide rod can rotate in the sleeve under the driving of the rotating assembly, so that the guide rod is switched between the first position and the second position.
The oscillation device is connected with the chromatography device and used for driving the chromatography device to vibrate.
The code scanning device is used for collecting information of the identification code arranged on the detection mechanism.
The image acquisition device is used for acquiring images of the color development areas on the test strip. The image acquisition device comprises a camera and an LED lamp.
Example 2
The utility model provides a high flux automation chromatography check out test set, includes chromatography device, test paper strip pusher, switches drive arrangement, shock device, sweeps a yard device, image acquisition device, incubation device and controlling means, test paper strip pusher, sweep a yard device, image acquisition device, switch drive arrangement, shock device, incubation device respectively with the controlling means electricity is connected.
The chromatography device comprises a liquid storage tank, a reaction cavity, a switching mechanism, a detection mechanism, a limiting device and a sealing element; the liquid storage tank is used for containing sample liquid; the top of the liquid storage tank is provided with a liquid injection port which is sealed by a cover body; the reaction cavity is arranged below the liquid storage tank, a longitudinal partition plate is arranged in the reaction cavity, and the inner cavity of the reaction cavity is divided into 8 mutually independent detection channels by the longitudinal partition plate; the top of the reaction cavity is provided with a test strip jack and a sample inlet at the position corresponding to each detection channel, the position of each test strip jack corresponds to each test strip, and the sample inlet is communicated with the liquid storage box through a switching mechanism; the switching mechanism is arranged between the liquid storage tank and the reaction cavity and is used for controlling the liquid storage tank to be communicated with or cut off from each detection channel of the reaction cavity; the switching mechanism comprises a sleeve fixedly arranged at the bottom in the liquid storage tank and a guide rod movably inserted in the sleeve; the sleeve is provided with 8 groups of first through holes which are arranged in an array and penetrate through the sleeve, and the guide rod is provided with 8 groups of second through holes which are arranged in an array and correspond to the first through holes; a spring is arranged in the sleeve, one end of the spring is fixed with one side of the guide rod, the other end of the spring is fixed with one side of the sleeve, the spring drives the guide rod to slide along the axial direction of the sleeve when being compressed or reset, so that the guide rod has a first position and a second position relative to the sleeve, and when the guide rod is positioned at the first position, the first through hole and the second through hole are mutually aligned and communicated to form a liquid channel so that the liquid storage tank is communicated with each detection channel of the reaction cavity; when the guide rod is located at the second position, the first through hole and the second through hole are mutually staggered and close the first through hole, so that the liquid storage tank and each detection channel of the reaction cavity are cut off; the detection mechanism comprises a shell, 8 accommodating grooves are formed in the shell and are arranged in parallel, the test strip is arranged in the corresponding accommodating groove, a sample pad of the test strip extends out of the shell to form a protruding part, and an observation window for observing the detection result of the test strip is arranged on the shell; the detection mechanism is arranged above the reaction cavity, is connected with the liquid storage box in a sliding manner and moves up and down along the outer wall of the liquid storage box, so that a sample pad of the test strip is contacted with or separated from sample liquid flowing into each detection channel of the reaction cavity; the test strip is an immunochromatography test strip, the immunochromatography test strip comprises a bottom plate, a sample pad, a chromatographic membrane and a water absorption pad are sequentially lapped on one side of the bottom plate according to the chromatographic direction, and a detection line and a quality control line corresponding to an object to be detected are arranged on the chromatographic membrane; an antibody marker of the substance to be detected or an antigen marker of the substance to be detected is fixed in the detection channel of the reaction cavity; the antibody marker of the substance to be detected is a block of an antibody-marker conjugate of the substance to be detected; the antigen marker of the substance to be detected is a block of an antigen-carrier protein-marker conjugate of the substance to be detected; the detection line is coated with an antibody of an object to be detected or an antigen-carrier protein conjugate of the object to be detected, and the quality control line is coated with a goat anti-rabbit IgG antibody or a goat anti-mouse IgG antibody; the marker is colloidal gold; the limiting device is used for limiting the position of the shell; the detection mechanism comprises a liquid storage tank, a shell, a detection mechanism and a detection mechanism, wherein L-shaped baffles extending towards the outer side of the liquid storage tank are arranged on two sides of the liquid storage tank, a sliding groove is formed between each L-shaped baffle and the liquid storage tank, and the shell of the detection mechanism is slidably mounted in the sliding groove; a limiting groove is formed in the L-shaped baffle, a buckle is arranged on the shell of the detection structure, and the limiting groove is connected with the buckle to limit the position of the test strip in the shell; the sealing element is arranged at the top of the reaction cavity and used for sealing the opening of the reaction cavity; the sealing element comprises a sealing film for sealing the socket of the test strip, and a puncturing device for puncturing the sealing film is arranged at the lower end of the shell of the detection mechanism; the lancing device includes a plurality of lancing members, which are sharp lancets.
The test strip pusher is arranged above the chromatographic device and used for driving the detection mechanism to slide along the outer wall of the liquid storage box, so that the sample pad of the test strip is in contact with the sample liquid circulating to each detection channel of the reaction cavity.
The switching driving device is arranged on one side of the chromatographic device and used for driving the switching mechanism to move so as to enable the liquid storage tank to be communicated with or cut off each detection channel of the reaction cavity; the switching driving device comprises a first push rod for pushing the guide rod and a first push rod driving mechanism for driving the first push rod to move, and the first push rod driving mechanism is electrically connected with the control device.
The oscillation device is connected with the chromatography device and used for driving the chromatography device to vibrate.
The code scanning device is used for collecting information of the identification code arranged on the detection mechanism.
The image acquisition device is used for acquiring images of the color development areas on the test strip; the image acquisition device comprises a camera and an LED lamp.
The chromatographic device is disposed within the incubation device.
The above-mentioned embodiments only express the embodiments of the present invention, and the description thereof is specific and detailed, but the invention can not be understood as the limitation of the patent scope of the present invention, but all the technical solutions obtained by adopting the equivalent substitution or equivalent transformation should fall within the protection scope of the present invention.
Claims (10)
1. A high throughput automated analytical detection apparatus, comprising:
the chromatographic device comprises a liquid storage tank, a reaction cavity, a switching mechanism and a detection mechanism; the liquid storage tank is used for containing sample liquid; the reaction cavity is arranged below the liquid storage tank and comprises at least two mutually independent detection channels; the switching mechanism is arranged between the liquid storage tank and the reaction cavity and is used for controlling the liquid storage tank to be communicated with or cut off from each detection channel of the reaction cavity; the detection mechanism comprises a shell and a plurality of mutually parallel test strips arranged in the shell; the detection mechanism is arranged above the reaction cavity and is in sliding connection with the liquid storage tank;
the test strip pushing device is arranged above the chromatographic device and used for driving the detection mechanism to slide along the outer wall of the liquid storage box, so that a sample pad of the test strip is contacted with sample liquid flowing to each detection channel of the reaction cavity;
the switching driving device is arranged on one side of the chromatographic device and is used for driving the switching mechanism to move;
the oscillation device is connected with the chromatography device and is used for driving the chromatography device to vibrate;
the code scanning device is used for acquiring the information of the identification code arranged on the detection mechanism;
the image acquisition device is used for acquiring an image of the color development area on the test strip;
and the control device is electrically connected with the test strip pushing device, the code scanning device, the image acquisition device, the switching driving device and the oscillating device respectively.
2. The high throughput automated analytical detection apparatus of claim 1, wherein a longitudinal partition is disposed in the reaction chamber, and the inner chamber of the reaction chamber is divided into a plurality of mutually independent detection channels by the longitudinal partition; the position of the top of the reaction cavity corresponding to each detection channel is provided with a test strip socket and a sample inlet, the position of each test strip socket corresponds to each test strip, and the sample inlet is communicated with the liquid storage box through the switching mechanism.
3. The high-throughput automated analytical detection apparatus according to claim 1, wherein the switching mechanism comprises a sleeve fixedly disposed at the bottom of the liquid storage tank and a guide rod movably inserted in the sleeve; the sleeve is provided with a plurality of groups of first through holes which are arranged in an array and penetrate through the sleeve, and the guide rod is provided with a plurality of groups of second through holes which are arranged in an array and correspond to the first through holes; the guide rod is provided with a first position and a second position relative to the sleeve, and when the guide rod is positioned at the first position, the first through hole and the second through hole are mutually aligned and communicated to form a liquid channel so that the liquid storage tank is communicated with each detection channel of the reaction cavity; when the guide rod is located at the second position, the first through hole and the second through hole are mutually staggered and enable the first through hole to be closed, and therefore the liquid storage tank and each detection channel of the reaction cavity are cut off.
4. The high throughput automated analytical analysis apparatus of claim 3, wherein the guide bar is rotatably inserted into the sleeve, the guide bar rotates relative to the sleeve to make the first through hole and the second through hole aligned with each other or staggered with each other, the switching driving device is a rotating component, the rotating component is connected to one side of the guide bar, and the guide bar can rotate in the sleeve under the driving of the rotating component, so that the guide bar is switched between the first position and the second position.
5. The high throughput automated analytical analysis inspection apparatus of claim 3, wherein a spring is disposed in the sleeve, one end of the spring is fixed to one side of the guide rod, and the other end of the spring is fixed to one side of the sleeve, and the spring drives the guide rod to slide along the axial direction of the sleeve when compressed or reset, so that the first through hole and the second through hole are aligned with each other or staggered with each other; the switching driving device comprises a first push rod for pushing the guide rod and a first push rod driving mechanism for driving the first push rod to move, and the first push rod driving mechanism is electrically connected with the control device.
6. The high throughput automated analytical detection apparatus of claim 1, wherein the test strip pushing device comprises a second push rod for pushing the housing, a second push rod driving mechanism for driving the second push rod to move, and the second push rod driving mechanism is electrically connected to the control device; the image acquisition device comprises a camera and an LED lamp.
7. The high throughput automated analytical detection apparatus of claim 1, further comprising an incubation device, the chromatographic device being disposed within the incubation device, the incubation device being electrically connected to the control device.
8. The high-throughput automated analytical detection device according to claim 1, wherein the liquid storage tank is provided with L-shaped baffles extending towards the outside of the liquid storage tank on both sides thereof, a sliding slot is formed between the L-shaped baffles and the liquid storage tank, and the housing of the detection mechanism is slidably mounted in the sliding slot; the L-shaped baffle is provided with a limiting groove, the shell of the detection mechanism is provided with a buckle, and the limiting groove is connected with the buckle to limit the position of the test strip in the shell.
9. The high throughput automated analytical detection apparatus of claim 1, wherein the top of the reaction chamber is provided with a sealing member for sealing the opening of the reaction chamber; the sealing element comprises a sealing film for sealing the socket of the test strip, and the lower end of the shell of the detection mechanism is provided with a puncturing device for puncturing the sealing film.
10. The high-throughput automated chromatography detection device according to claim 1, wherein the test strip is an immunochromatographic test strip, the immunochromatographic test strip comprises a bottom plate, a sample pad, a chromatographic membrane and a water absorption pad are sequentially overlapped on one side of the bottom plate according to a chromatography direction, and the chromatographic membrane is provided with a detection line and a quality control line corresponding to the object to be detected; an antibody marker of the substance to be detected or an antigen marker of the substance to be detected is fixed in the detection channel of the reaction cavity.
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| CN201920559877.2U CN210037822U (en) | 2019-04-23 | 2019-04-23 | High-flux automatic chromatography detection equipment |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110221054A (en) * | 2019-04-23 | 2019-09-10 | 深圳市易瑞生物技术股份有限公司 | A kind of high throughput automated chromatography detection device |
| CN115032404A (en) * | 2022-06-10 | 2022-09-09 | 杨富松 | Vaccine antibody detection card, detection system and detection method thereof |
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2019
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110221054A (en) * | 2019-04-23 | 2019-09-10 | 深圳市易瑞生物技术股份有限公司 | A kind of high throughput automated chromatography detection device |
| CN110221054B (en) * | 2019-04-23 | 2024-02-23 | 深圳市易瑞生物技术股份有限公司 | High-flux automatic chromatographic detection equipment |
| CN115032404A (en) * | 2022-06-10 | 2022-09-09 | 杨富松 | Vaccine antibody detection card, detection system and detection method thereof |
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