CN109669038A - A kind of portable multi-channel chromatographic apparatus - Google Patents
A kind of portable multi-channel chromatographic apparatus Download PDFInfo
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- CN109669038A CN109669038A CN201910152207.3A CN201910152207A CN109669038A CN 109669038 A CN109669038 A CN 109669038A CN 201910152207 A CN201910152207 A CN 201910152207A CN 109669038 A CN109669038 A CN 109669038A
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- Prior art keywords
- reaction chamber
- reserve tank
- liquid reserve
- hole
- test strips
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- 238000012360 testing method Methods 0.000 claims abstract description 176
- 239000007788 liquid Substances 0.000 claims abstract description 165
- 238000006243 chemical reaction Methods 0.000 claims abstract description 121
- 238000001514 detection method Methods 0.000 claims abstract description 57
- 230000007246 mechanism Effects 0.000 claims abstract description 24
- 238000007789 sealing Methods 0.000 claims description 47
- 238000002347 injection Methods 0.000 claims description 30
- 239000007924 injection Substances 0.000 claims description 30
- 239000003550 marker Substances 0.000 claims description 29
- 238000004587 chromatography analysis Methods 0.000 claims description 17
- 238000010521 absorption reaction Methods 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 230000000890 antigenic effect Effects 0.000 claims description 11
- 241000283707 Capra Species 0.000 claims description 5
- 241001494479 Pecora Species 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
- 239000012530 fluid Substances 0.000 claims description 5
- 239000002105 nanoparticle Substances 0.000 claims description 4
- 238000005192 partition Methods 0.000 claims description 4
- 239000006249 magnetic particle Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 16
- 238000000034 method Methods 0.000 description 15
- 238000003317 immunochromatography Methods 0.000 description 6
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical group [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 4
- REDXJYDRNCIFBQ-UHFFFAOYSA-N aluminium(3+) Chemical compound [Al+3] REDXJYDRNCIFBQ-UHFFFAOYSA-N 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000005725 8-Hydroxyquinoline Substances 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 239000005030 aluminium foil Substances 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 229960003540 oxyquinoline Drugs 0.000 description 1
- 229920006267 polyester film Polymers 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000002096 quantum dot Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
Abstract
The invention discloses a kind of portable multi-channel chromatographic apparatus, comprising: liquid reserve tank；Reaction chamber is set to below the liquid reserve tank, and the reaction chamber includes at least two mutually independent sense channels；Switching mechanism is set between the liquid reserve tank and reaction chamber, is connected or ends with each sense channel of reaction chamber for controlling liquid reserve tank；Testing agency, including shell and the multiple test strips being parallel to each other being set in the housing；The testing agency is set to above reaction chamber, and the testing agency is slidably connected with liquid reserve tank, and the testing agency moves up and down along the liquid storage box outer wall.The invention enables the sample liquids in liquid reserve tank can synchronize in each sense channel being evenly distributed in reaction chamber, realizes mean allocation sample-adding amount, improves the accuracy of sample-adding；The independent reaction chromatographed in each sense channel can satisfy the demand of environmentally sensitive type test；The detection of plurality of target detectable substance can be realized in primary sample-adding, realizes high-throughput detection.
Description
Technical field
The present invention relates to technical field of biological, more particularly to a kind of portable multi-channel chromatographic apparatus.
Background technique
Chromatographing detection to be is being in recent years a kind of important field quick detection form, because convenient, fast in clinical, food peace
Entirely, very popular in the fields such as environment measuring.Currently, chromatography usually needs to apply multiple test strips more to simple sample progress
A Indexs measure.When detection, it is common practice that sample liquid is placed in a public cavity, is then put into test strips,
Specific time reads result.Such way is only applicable to the chromatography of one-step method, can not be compatible with two-step method.And public chamber is to ring
The demanding detection process in border can generate pollution, be unable to satisfy such as nucleic acid detection project.Other methods are to pass through individual flow
Road enters each independent chromatography reaction chamber to the separating liquid in public chamber, then closes to runner, to realize layer
Analyse the interval of reaction process.But this way is only applicable to the chromatography reaction of one-step method, then cannot achieve for two-step method.
Summary of the invention
In order to make up the defect of prior art, the present invention provides a kind of portable multi-channel chromatographic apparatus.
The technical problems to be solved by the invention are achieved by the following technical programs:
A kind of portable multi-channel chromatographic apparatus, comprising:
Liquid reserve tank, for accommodating sample liquid；
Reaction chamber is set to below the liquid reserve tank, and the reaction chamber includes at least two mutually independent sense channels；
Switching mechanism is set between the liquid reserve tank and reaction chamber, for controlling each sense channel phase of the liquid reserve tank with reaction chamber
Connection or cut-off；
Testing agency, including shell and the multiple test strips being parallel to each other being set in the housing；The testing agency is set to institute
It states above reaction chamber, the testing agency is slidably connected with the liquid reserve tank, and the testing agency is along the liquid storage box outer wall
It moves up and down, so that the sample pad of the test strips is contacted or separated with the sample liquid being passed in each sense channel of reaction chamber.
Further, liquid injection port is provided at the top of the liquid reserve tank, the liquid injection port is sealed with lid.
Further, longitudinal baffle is provided in the reaction chamber, the inner cavity of the reaction chamber is divided by longitudinal baffle
Multiple mutually independent sense channels；The position that the top of the reaction chamber corresponds to each sense channel is equipped with test strips socket
And injection port, the position of each test strips socket is corresponding with every test strips, and the injection port passes through the switching mechanism and institute
Liquid reserve tank is stated to be connected.
Further, the switching mechanism includes being fixedly arranged on the sleeve of bottom and activity in the liquid reserve tank to be inserted in institute
State the guide rod in sleeve；The sleeve is equipped with the first through hole through the sleeve of several groups array arrangement, the guide rod
It is equipped with the second through-hole of the several groups display arrangement of the corresponding first through hole；The guide rod relative sleeve has first position
And the second position, when the guide rod is located at first position, the first through hole is mutually aligned with the second through-hole and is connected to, and forms liquid
Body channel makes liquid reserve tank be connected with each sense channel of reaction chamber；When the guide rod is located at the second position, described first
Through-hole and the second through-hole mutually stagger and first through hole are closed, so that each sense channel of liquid reserve tank and reaction chamber ends.
Further, the guide rod is rotationally inserted in the sleeve, and the guide rod is rotated relative to the sleeve
When the first through hole is mutually aligned with the second through-hole be connected to or mutually stagger, the side of the guide rod be equipped with can drive it is described
The knob that guide rod rotates between the first position and the second position in sleeve.
Further, spring is provided in the sleeve, one end and the guide rod side of spring are fixed, the other end and the set
Cylinder side fix, spring-compressed or reset when drive the guide rod along sleeve axis direction slide, make the first through hole with
Second through-hole is mutually aligned connection or mutually staggers.
Further, further include limiting device for limiting the shell position.
Further, the two sides of the liquid reserve tank are all provided with the L shape baffle that oriented liquid reserve tank lateral direction extends, the L shape
Sliding slot is formed between baffle and liquid reserve tank, the shell of the testing agency is slidably mounted in the sliding slot；On the L shape baffle
It is provided with limiting slot, buckle is set on the shell of the detection structure, the limiting slot is by limiting institute with described snap connection
State the position of test strips in shell.
Further, the top of the reaction chamber is equipped with the sealing element for sealing reaction chamber opening；The sealing element packet
Include the sealing film for sealing test strips socket, the shell lower end of the testing agency be equipped be used to puncture the sealing film puncture dress
It sets.
Further, at least two holding tanks are equipped in the shell, the holding tank is arranged in parallel, the test paper
Item is placed in corresponding holding tank, and the sample pad of the test strips stretches out in outside shell and forms extension, is arranged on the shell
There is the observation window for observing test strips testing result.
Further, the test strips are immuno-chromatographic test paper strip, and the immunity test strip includes bottom plate, in the bottom plate
It is successively overlapped with sample pad, chromatographic film, water absorption pad by chromatography direction on side, the chromatographic film is equipped with corresponding with determinand
Detection line and nature controlling line；The antibody marker of determinand or resisting for determinand are fixed in the sense channel of the reaction chamber
Former marker.
Further, the antibody marker of the determinand is the block of the antibody-marker object conjugate of determinand；Institute
The antigenic label for stating determinand is antigen-carrier albumen-marker conjugate block of determinand；In the detection line
It is coated with the antibody of determinand or the antigen-carrier protein conjugate of determinand, is coated with goat anti-rabbit igg on the nature controlling line
Antibody or sheep anti-mouse igg antibody；The marker is colloidal gold or fluorescent nano particle.
Further, the test strips are chemical detection test strips, and the chemical detection test strips include bottom plate, described
It is successively overlapped with sample pad, chromatographic film, water absorption pad by chromatography direction on bottom plate side, chemical examination is evenly equipped in the chromatographic film
With the determinand in sample liquid color change after specific chemical reacts occurs for agent, the chemical reagent.
Further, the test strips socket, the injection port, the first through hole, second through-hole and the examination
The quantity of paper slip is identical, is 4-8.
The invention has the following beneficial effects:
The present invention between liquid reserve tank and reaction tank by being arranged switching mechanism, for controlling each detection of liquid reserve tank and reaction chamber
Channel is connected or ends, and reaction chamber includes at least two mutually independent sense channels, so that the sample liquid in liquid reserve tank can
To synchronize in each sense channel being evenly distributed in reaction chamber, realizes mean allocation sample-adding amount, improve the accurate of sample-adding
Degree, and the sample liquid in each sense channel can be adjusted as required at any time, and switching mode is reliable, easy to operate；Respectively
The independent reaction chromatographed in sense channel can satisfy the demand of environmentally sensitive type test, can be avoided cross-infection, guarantees
The accuracy of testing result；The detection of plurality of target detectable substance can be realized in primary sample-adding, solves sample present in joint-detection
The problem that the distribution of product liquid is uneven and distribution is uncontrollable, multinomial detection can stable progress simultaneously, realize high-throughput detection, have
Effect reduces testing staff's workload, improves detection efficiency.
In the present invention, the testing agency is slidably connected with the liquid reserve tank, and the testing agency is along the liquid reserve tank
Outer wall moves up and down, so that the sample pad of the test strips contacts or divides with the sample liquid being passed in each sense channel of reaction chamber
From.By this set, the detection of the test strips of two-step method not only may be implemented, moreover, if the sample liquid in liquid reserve tank needs
It mixes, the liquid reserve tank can be rocked manually, test strips will not be polluted, adjacent reaction hole will not be interfered, without liquid-transfering gun etc.
Liquid shifting equipment has the characteristics that high sensitivity, high specific, using simple and direct, low in cost.
It using the detection that chromatographic apparatus of the invention carries out is carried out in the system of a relative closure, also in certain journey
A possibility that reducing sample contamination and detection pollution on degree, the stability of detection is further improved, artificial behaviour is decreased
Make the hidden danger of error.
In the present invention, according to actually detected demand, the test strips of detection different material can be selected to combine with reaction tank, it is full
Sufficient different demands.
It in the present invention, after the completion of test strips detection, arranges uniform, easily can accurately be read in readout instrument reading
It takes, without being one by one aligned test strips, reduces error.
In the present invention, test strips are placed in shell, so that test strips itself are not easy to receive in operator's operating process
It pollutes (gloves or hand), operates more convenient.
Detailed description of the invention
Fig. 1 is structure chart of the invention；
Fig. 2 is a kind of perspective view of switching mechanism of the present invention；
Fig. 3 is another perspective view of switching mechanism of the present invention.
In figure: 1, liquid reserve tank, 2, reaction chamber, 3, sleeve, 4, guide rod, 5, knob, 6, first through hole, the 7, second through-hole, 8,
Testing agency, 9, injection port, 10, test strips socket, 11, observation window, 12, L shape baffle, 13, limiting slot, 14, buckle, 15, bullet
Spring.
Specific embodiment
A kind of portable multi-channel chromatographic apparatus, comprising: liquid reserve tank, reaction chamber, switching mechanism and testing agency.
The liquid reserve tank is for accommodating sample liquid.Liquid injection port, the liquid injection port lid are provided at the top of the liquid reserve tank
Body sealing.
The reaction chamber is set to below the liquid reserve tank, and the reaction chamber includes that at least two mutually independent detections are logical
Road.
The present invention is not particularly limited the quantity of test strips in shell, and those skilled in the art can be according to actually detected
Need to carry out flexible setting, preferably, the quantity of the sense channel can be 2-8, such as can be 6,7,8
It is a.
Specifically, longitudinal baffle is provided in the reaction chamber, the inner cavity of the reaction chamber is divided into more by longitudinal baffle
A mutually independent sense channel；The position that the top of the reaction chamber corresponds to each sense channel be equipped with test strips socket and
The position of injection port, each test strips socket is corresponding with every test strips, the injection port by the switching mechanism with it is described
Liquid reserve tank is connected.
The reaction chamber is detachably connected with the liquid reserve tank.The present invention does not make specifically the concrete mode being detachably connected
It limits, can be realized using usual manner in the prior art, be known to those skilled in the art.
The switching mechanism is set between the liquid reserve tank and reaction chamber, for controlling each detection of liquid reserve tank and reaction chamber
Channel is connected or ends.
The switching mechanism includes being fixedly arranged on the sleeve of bottom and activity in the liquid reserve tank to be inserted in the sleeve
Guide rod；The sleeve be equipped with several groups array arrangement the first through hole through the sleeve, the guide rod equipped with pair
The several groups of the first through hole are answered to display the second through-hole of arrangement；The guide rod relative sleeve has first position and second
It sets, when the guide rod is located at first position, the first through hole is mutually aligned with the second through-hole and is connected to, and forming fluid passage makes
Liquid reserve tank is obtained to be connected with each sense channel of reaction chamber；When the guide rod is located at the second position, the first through hole and
Two through-holes mutually stagger and first through hole are closed, so that each sense channel of liquid reserve tank and reaction chamber ends.
The first through hole is along the length direction array arrangement of the sleeve, and second through-hole is along the guide rod length side
To array arrangement.
The present invention does not limit the array arrangement mode of first through hole and the second through-hole, as an example, described first specifically
Through-hole can be set to a row, may be set to be two rows.
Preferably, referring to Fig.2, the guide rod is rotationally inserted in the sleeve, the guide rod is relative to the set
It is mutually aligned the first through hole with the second through-hole when cylinder rotation to be connected to or mutually stagger, the side of the guide rod is equipped with can band
Move the knob that the guide rod rotates between the first position and the second position in sleeve.
It is highly preferred that being provided with spring in the sleeve refering to Fig. 3, one end and the guide rod side of spring are fixed, the other end
It is fixed with the sleeve side, spring-compressed or while resetting drive the guide rod to slide along sleeve axis direction, make described the
One through-hole is mutually aligned with the second through-hole and is connected to or mutually staggers.
It should be noted that the guide rod is inserted in completely in the sleeve when amount of spring compression maximum rating, institute at this time
It states first through hole and is mutually aligned with the second through-hole and is connected to.
The first through hole is identical with the group number of the second through-hole, group number according to the quantity of sense channel in reaction chamber and
It is fixed.
The position of each injection port is corresponding with first through hole.It is appreciated that the bottom of the liquid reserve tank is the sleeve
Bottom, the sample liquid placed in the liquid reserve tank entered in sense channel by the relative motion of the sleeve and guide rod.
In the present invention, using this switching mechanism, the sample liquid in liquid reserve tank is synchronized and is evenly distributed to reaction
In each sense channel in chamber, realizes mean allocation sample-adding amount, improve the accuracy of sample-adding, and in each sense channel
Sample liquid can be adjusted as required at any time, and switching mode is reliable, easy to operate.
The testing agency includes shell and the multiple test strips being parallel to each other being set in the housing.In the present invention, and
Do not limit the modes of emplacement between shell and test strips specifically, as long as test strips is made to be easy to fix and remove out shell,
Those skilled in the art can set according to actual needs.Preferably, at least two holding tanks, institute are equipped in the shell
It is arranged in parallel to state holding tank, the test strips are placed in corresponding holding tank, and the sample pad of the test strips stretches out in shell
It is external to form extension.
The observation window for observing test strips testing result is provided on the shell.In order to improve airtightness, the sight
It examines window and is embedded in and be provided with transparent panel.
The shell is also possible to transparent, does not need that observation window additionally is arranged at this time.
In the present invention, the quantity of test strips in shell is not particularly limited, those skilled in the art can be according to reality
Detection needs to carry out flexible setting, preferably, the quantity of the test strips can be 6-8, such as can be 6,7
It is a, 8.
The testing agency is set to above the reaction chamber, and the testing agency is slidably connected with the liquid reserve tank, described
Testing agency moves up and down along the liquid storage box outer wall so that the sample pad of the test strips be passed to reaction chamber and respectively detect
Sample liquid contact or separation in channel.
Chromatographic apparatus of the invention can be used for chemical detection, and the test strips are chemical detection test strips, the chemistry
Test strip includes bottom plate, is successively overlapped with sample pad, chromatographic film, water absorption pad by chromatography direction on the bottom plate side,
Chemical reagent is evenly equipped in the chromatographic film, after the chemical reagent is reacted with the determinand generation specific chemical in sample liquid
Color change.
As an example, when the determinand in sample liquid is aluminium ion, 8- Hydroxy-quinolin, chemistry inspection are evenly equipped in chromatographic film
Test paper slip in sample pad contact with sample liquid carry out chromatograph react when, if containing aluminium ion in sample liquid, aluminium ion is through layer
8-hydroxyquinoline in analysis effect and chromatographic film plays high specific chemical reaction, so that chromatographic film is become yellow from colourless, to reach
To the purpose quickly detected.
Chromatographic apparatus of the invention can be also used for immune detection, and the test strips are immuno-chromatographic test paper strip.
When chromatographic apparatus of the invention is used for immune detection, it can be used for the immunochromatography of one-step method, can be used for two
The immunochromatography of footwork.
When chromatographic apparatus of the invention is used for the immunochromatography of one-step method, the test strips include bottom plate, at the bottom
On plate side by chromatography direction be successively overlapped with sample pad, bonding pad, chromatographic film, water absorption pad, be fixed on the bonding pad to
Survey the antibody marker of object or the antigenic label of determinand；The chromatographic film be equipped with detection line corresponding with determinand with
And nature controlling line.
When chromatographic apparatus of the invention is used for the immunochromatography of two-step method, the immuno-chromatographic test paper strip includes bottom plate,
Successively be overlapped with sample pad, chromatographic film, water absorption pad by chromatography direction on the bottom plate side, the chromatographic film be equipped with to
Survey the corresponding detection line of object and nature controlling line.Specifically, the immuno-chromatographic test paper strip include bottom plate, sample pad, chromatographic film,
Water absorption pad, the bottom plate side are equipped with sample pad, and the other side is equipped with water absorption pad, and chromatographic film is equipped between sample pad and water absorption pad,
Neighboring samples pad and chromatographic film are overlapped in junction and are connected in the overlapping connection in junction, the chromatographic film and water absorption pad, chromatographic film
Middle part be equipped with detection line and nature controlling line, close to sample pad, the sample pad of the test strips is stretched out in outside shell and is formed detection line
Extension；The antibody marker of determinand or the antigenic label of determinand are fixed in the sense channel of the reaction chamber.
Marker conjugate coated in existing bonding pad is set to each detection of reaction chamber by the immunochromatography of two-step method
In channel, reacts it first more fully with analyte sample fluid, improve in Traditional immunochromatographic test strips on bonding pad
Reaction is not thorough, not exclusively, the defects of low efficiency, and so that determinand thoroughly reacts in homogeneous system with marker conjugate,
Improve sensitivity.
The sample pad is polyester film, glass or filter paper with sample filtering function.
The water absorption pad is blotting paper；The chromatographic film is nitrocellulose filter or cellulose acetate film.
The marker is the substance that can be used to identify and detect acquisition signal, such as colloidal gold, but not limited to this, make
For citing, latex, fluorescent nano particle, quantum dot or up-conversion luminescence substance etc. can also be.The present invention not only can satisfy
The testing requirements of fast qualitative can also carry out Effective judgement to sample result and sample amounts are analyzed.
The antibody marker of the determinand is the block of the antibody-marker object conjugate of determinand；The determinand
Antigenic label be determinand antigen-carrier albumen-marker conjugate block；Be coated in the detection line to
The antibody of object or the antigen-carrier protein conjugate of determinand are surveyed, is coated with goat anti-rabbit igg antibody or sheep on the nature controlling line
Dynamics.
The test strips socket, the injection port, the first through hole, the quantity of second through-hole and the test strips
It is all the same.
It further include the limiting device for limiting the shell position in the present invention, so that the intracorporal test strips of the shell
It is contacted with the sample liquid in sense channel when being immunoreacted, shell is fixed.By this set, so that the intracorporal examination of shell
Paper slip, which will not be excessively pushed into the sense channel of reaction chamber, causes test strips to fracture, will not make when detecting shell it is upward
It is mobile to cause immune response to stop so that the intracorporal test strips of shell are separated with the sample liquid in sense channel.
The limiting device is preferably notch.Specifically, the two sides of the liquid reserve tank are all provided on the outside of oriented liquid reserve tank
The L shape baffle that direction extends, forms sliding slot, the shell of the testing agency is slidably installed between the L shape baffle and liquid reserve tank
In the sliding slot；It is provided with limiting slot on the L shape baffle, is set to buckle, the limit on the shell of the detection structure
Slot limits the shell and continues to slide towards the reaction chamber by limiting the positions of the test strips with described snap connection.
In the present invention, the top of the reaction chamber is equipped with the sealing element for sealing reaction chamber opening, for sealing reaction
The space in intracavitary portion is not in contact with the external world.
The sealing element includes the sealing film for sealing test strips socket, and the shell lower end of the testing agency, which is equipped with, to be used to pierce
Break the lancing device of the sealing film.
It is appreciated that the lancing device extends from shell lower end, the extension projected outward from the housing is formed.
In the present invention, the selection of the sealing film should have certain leakproofness to preservation liquid, and be easy sharp
What substance punctured punctures membrane material, and typical but non-limiting is, for example, masking foil or aluminium-foil paper etc..
In the present invention, lancing device is not particularly limited, as long as guarantee test strips being inserted into test strips insert port,
Sealing film can be punctured.As a preferred embodiment, the port of lancing device is serrated, sealing can be punctured
Film.As another preferred embodiment, lancing device include it is multiple puncture part, sealing film can be punctured, it is preferred to puncture part
For spine.
Test strips socket in the present invention is using the sealing means sealing for being easy to puncture, in testing agency's shell slide downward
When, the lancing device of shell lower end setting punctures sealing film, so that marker fixed in advance in each sense channel in reaction chamber
It can preferably save, guarantee the accuracy of testing result.
The sealing element further includes the diaphragm seal being covered on outside the injection port, when detection, can first be taken the diaphragm seal away,
Then the reaction chamber is connected to below liquid reserve tank.
For carrying out immune detection using two-step method, detection method of the invention is: acquisition sample, at sample
Reason obtains sample liquid；Moveable combination of guide rod, so that guide rod is in the second position, the first through hole and the second through-hole mutually stagger and make
First through hole closing, liquid bulk channel is closed so that each sense channel of liquid reserve tank and reaction chamber ends；Sample liquid is put into storage
In liquid case；Moveable combination of guide rod, so that guide rod is in first position, the first through hole is mutually aligned with the second through-hole and is connected to, and is formed
Fluid passage makes liquid reserve tank be connected with each sense channel of reaction chamber, the sample liquid in liquid reserve tank by reaction chamber into
Sample mouth flows into each sense channel；Moveable combination of guide rod, so that guide rod is in the second position, the first through hole and the second through-hole phase
It is mutually staggered and closes first through hole, liquid bulk channel is closed so that each sense channel of liquid reserve tank and reaction chamber ends；Shaking
Device for a period of time so that determinand in sample liquid first with the antibody marker of the determinand of fixation in sense channel or to be measured
The antigenic label of object reacts, and after reaction, by assembled testing agency's slide downward, shell lower end is set in testing agency
The lancing device set punctures sealing film, so that test strips are inserted into the test strips socket on reaction chamber, the sample pad of test strips
Contacted with the sample liquid in sense channel carry out immunochromatography reaction, visually observe or instrument scanning chromatographic film on each detection line
The power of signal, determines the number of respective objects substance in sample, and signal gets over the content of respective objects substance in weak sample also just
It is higher.Entire detection process is carried out in two steps, i.e., immune combination and Immune competition, due to this feature, so reaction is sufficiently, spirit
Quick raising, easy to operate, detection is specific antigen-antibody reaction, so having the characteristics that high specificity, accuracy are high.
The present invention will now be described in detail with reference to examples, and the examples are only preferred embodiments of the present invention,
It is not limitation of the invention.
Embodiment 1
A kind of portable multi-channel chromatographic apparatus, comprising:
Liquid reserve tank, for accommodating sample liquid；Liquid injection port is provided at the top of the liquid reserve tank, the liquid injection port is sealed with lid；
Reaction chamber is set to below the liquid reserve tank, is provided with longitudinal baffle in the reaction chamber, the inner cavity of the reaction chamber is indulged
6 mutually independent sense channels are divided into partition；The position that the top of the reaction chamber corresponds to each sense channel is all provided with
There are test strips socket and injection port, the position of each test strips socket is corresponding with every test strips, and the injection port passes through switching
Mechanism is connected with the liquid reserve tank；
Switching mechanism is set between the liquid reserve tank and reaction chamber, for controlling each sense channel phase of the liquid reserve tank with reaction chamber
Connection or cut-off；The switching mechanism includes being fixedly arranged on the sleeve of bottom in the liquid reserve tank and being rotationally inserted in described
Guide rod in sleeve；The sleeve is equipped with the first through hole through the sleeve of 6 group patterns arrangement, and the guide rod is equipped with
Second through-hole of 6 groups of displays arrangement of the corresponding first through hole；The guide rod rotate when relative sleeve have first position and
The second position, when the guide rod is located at first position, the first through hole is mutually aligned with the second through-hole and is connected to, and forms liquid
Channel makes liquid reserve tank be connected with each sense channel of reaction chamber；When the guide rod is located at the second position, described first is logical
Hole and the second through-hole mutually stagger and first through hole are closed, so that each sense channel of liquid reserve tank and reaction chamber ends；Institute
The side for stating guide rod is equipped with the knob that the guide rod can be driven to rotate between the first position and the second position in sleeve；
Testing agency, including shell, the shell is interior to be equipped with 6 holding tanks, and the holding tank is arranged in parallel, the test paper
Item is placed in corresponding holding tank, and the sample pad of the test strips stretches out in outside shell and forms extension, is arranged on the shell
There is the observation window for observing test strips testing result；The testing agency is set to above the reaction chamber, the testing agency
It being slidably connected with the liquid reserve tank, the testing agency moves up and down along the liquid storage box outer wall, so that the test strips
Sample pad is contacted or is separated with the sample liquid being passed in each sense channel of reaction chamber；The test strips are immune chromatography test paper
Item, the immunity test strip include bottom plate, on the bottom plate side by chromatography direction be successively overlapped with sample pad, chromatographic film,
Water absorption pad, the chromatographic film are equipped with detection line corresponding with determinand and nature controlling line；The sense channel of the reaction chamber
In be fixed with the antibody marker of determinand or the antigenic label of determinand；The antibody marker of the determinand is determinand
Antibody-marker object conjugate block；The antigenic label of the determinand is antigen-carrier albumen-mark of determinand
Remember the block of object conjugate；The antigen-carrier albumen of antibody or determinand that determinand is coated in the detection line is even
Join object, is coated with goat anti-rabbit igg antibody or sheep anti-mouse igg antibody on the nature controlling line；The marker is colloidal gold；
Limiting device, for limiting the position of the shell；The two sides of the liquid reserve tank are all provided with oriented liquid reserve tank lateral direction and prolong
The L shape baffle stretched, forms sliding slot between the L shape baffle and liquid reserve tank, the shell of the testing agency is slidably mounted on described
In sliding slot；It is provided with limiting slot on the L shape baffle, is set to buckle on the shell of the detection structure, the limiting slot passes through
With the position for snapping connection test strips in the restriction shell；
Sealing element, set on the top of the reaction chamber, for sealing reaction chamber opening；The sealing element includes sealing test strips to insert
The sealing film of mouth, the shell lower end of the testing agency are equipped with the lancing device for being used to puncture the sealing film；It is described to puncture dress
It sets and punctures part including multiple, puncturing part is spine.
Embodiment 2
A kind of portable multi-channel chromatographic apparatus, comprising:
Liquid reserve tank, for accommodating sample liquid；Liquid injection port is provided at the top of the liquid reserve tank, the liquid injection port is sealed with lid；
Reaction chamber is set to below the liquid reserve tank, is provided with longitudinal baffle in the reaction chamber, the inner cavity of the reaction chamber is indulged
8 mutually independent sense channels are divided into partition；The position that the top of the reaction chamber corresponds to each sense channel is all provided with
There are test strips socket and injection port, the position of each test strips socket is corresponding with every test strips, and the injection port passes through described
Switching mechanism is connected with the liquid reserve tank；
Switching mechanism is set between the liquid reserve tank and reaction chamber, for controlling each sense channel phase of the liquid reserve tank with reaction chamber
Connection or cut-off；The switching mechanism includes being fixedly arranged on the sleeve of bottom in the liquid reserve tank and being rotationally inserted in described
Guide rod in sleeve；The sleeve is equipped with the first through hole through the sleeve of 8 group patterns arrangement, and the guide rod is equipped with
Second through-hole of 8 groups of displays arrangement of the corresponding first through hole；Spring, one end of spring and guide rod are provided in the sleeve
Side is fixed, and the other end is fixed with the sleeve side, spring-compressed or reset when drive the guide rod along sleeve axis side
To sliding, make the guide rod relative sleeve that there is first position and the second position, it is described when the guide rod is located at first position
First through hole is mutually aligned with the second through-hole and is connected to, and forms fluid passage and liquid reserve tank is connected with each sense channel of reaction chamber
It is logical；When the guide rod is located at the second position, the first through hole and the second through-hole mutually stagger and first through hole are closed,
So that each sense channel of liquid reserve tank and reaction chamber ends；
Testing agency, including shell, the shell is interior to be equipped with 8 holding tanks, and the holding tank is arranged in parallel, the test paper
Item is placed in corresponding holding tank, and the sample pad of the test strips stretches out in outside shell and forms extension, is arranged on the shell
There is the observation window for observing test strips testing result；The testing agency is set to above the reaction chamber, the testing agency
It being slidably connected with the liquid reserve tank, the testing agency moves up and down along the liquid storage box outer wall, so that the test strips
Sample pad is contacted or is separated with the sample liquid being passed in each sense channel of reaction chamber；The test strips are immune chromatography test paper
Item, the immuno-chromatographic test paper strip include bottom plate, are successively overlapped with sample pad by chromatography direction on the bottom plate side, combine
Pad, chromatographic film, water absorption pad are fixed with the antibody marker of determinand or the antigenic label of determinand on the bonding pad；Institute
Chromatographic film is stated equipped with detection line corresponding with determinand and nature controlling line；The antibody marker of the determinand is determinand
Antibody-marker object conjugate block；The antigenic label of the determinand is antigen-carrier albumen-mark of determinand
Remember the block of object conjugate；The antigen-carrier albumen of antibody or determinand that determinand is coated in the detection line is even
Join object, is coated with goat anti-rabbit igg antibody or sheep anti-mouse igg antibody on the nature controlling line；The marker is colloidal gold or fluorescence
Nano particle.
Limiting device, for limiting the position of the shell；The two sides of the liquid reserve tank are all provided with oriented liquid reserve tank outside
To the L shape baffle of extension, sliding slot is formed between the L shape baffle and liquid reserve tank, the shell of the testing agency is slidably mounted on
In the sliding slot；It is provided with limiting slot on the L shape baffle, is set to buckle, the limiting slot on the shell of the detection structure
By limiting the positions of test strips in the shell with described snap connection；
Sealing element, set on the top of the reaction chamber, for sealing reaction chamber opening；The sealing element includes sealing test strips to insert
The sealing film of mouth, the shell lower end of the testing agency are equipped with the lancing device for being used to puncture the sealing film.
Embodiment 3
A kind of portable multi-channel chromatographic apparatus, comprising:
Liquid reserve tank, for accommodating sample liquid；Liquid injection port is provided at the top of the liquid reserve tank, the liquid injection port is sealed with lid；
Reaction chamber is set to below the liquid reserve tank, is provided with longitudinal baffle in the reaction chamber, the inner cavity of the reaction chamber is indulged
4 mutually independent sense channels are divided into partition；The position that the top of the reaction chamber corresponds to each sense channel is all provided with
There are test strips socket and injection port, the position of each test strips socket is corresponding with every test strips, and the injection port passes through switching
Mechanism is connected with the liquid reserve tank；
Switching mechanism is set between the liquid reserve tank and reaction chamber, for controlling each sense channel phase of the liquid reserve tank with reaction chamber
Connection or cut-off；The switching mechanism includes being fixedly arranged on the sleeve of bottom in the liquid reserve tank and being rotationally inserted in described
Guide rod in sleeve；The sleeve is equipped with the first through hole through the sleeve of 4 group patterns arrangement, and the guide rod is equipped with
Second through-hole of 6 groups of displays arrangement of the corresponding first through hole；The guide rod rotate when relative sleeve have first position and
The second position, when the guide rod is located at first position, the first through hole is mutually aligned with the second through-hole and is connected to, and forms liquid
Channel makes liquid reserve tank be connected with each sense channel of reaction chamber；When the guide rod is located at the second position, described first is logical
Hole and the second through-hole mutually stagger and first through hole are closed, so that each sense channel of liquid reserve tank and reaction chamber ends；Institute
The side for stating guide rod is equipped with the knob that the guide rod can be driven to rotate between the first position and the second position in sleeve；
Testing agency, including shell, the shell is interior to be equipped with 4 holding tanks, and the holding tank is arranged in parallel, the test paper
Item is placed in corresponding holding tank, and the sample pad of the test strips stretches out in outside shell and forms extension, is arranged on the shell
There is the observation window for observing test strips testing result；The testing agency is set to above the reaction chamber, the testing agency
It being slidably connected with the liquid reserve tank, the testing agency moves up and down along the liquid storage box outer wall, so that the test strips
Sample pad is contacted or is separated with the sample liquid being passed in each sense channel of reaction chamber；The test strips are chemical detection test paper
Item, the chemical detection test strips include bottom plate, are successively overlapped with sample pad, chromatography by chromatography direction on the bottom plate side
Film, water absorption pad are evenly equipped with chemical reagent in the chromatographic film, and specificity occurs for the determinand in the chemical reagent and sample liquid
Color change after chemical reaction；
Limiting device, for limiting the position of the shell；The two sides of the liquid reserve tank are all provided with oriented liquid reserve tank lateral direction and prolong
The L shape baffle stretched, forms sliding slot between the L shape baffle and liquid reserve tank, the shell of the testing agency is slidably mounted on described
In sliding slot；It is provided with limiting slot on the L shape baffle, is set to buckle on the shell of the detection structure, the limiting slot passes through
With the position for snapping connection test strips in the restriction shell；
Sealing element, set on the top of the reaction chamber, for sealing reaction chamber opening；The sealing element includes sealing test strips to insert
The sealing film of mouth, the shell lower end of the testing agency are equipped with the lancing device for being used to puncture the sealing film；It is described to puncture dress
It sets and punctures part including multiple, puncturing part is spine.
Embodiments of the present invention above described embodiment only expresses, the description thereof is more specific and detailed, but can not
Therefore limitations on the scope of the patent of the present invention are interpreted as, as long as skill obtained in the form of equivalent substitutions or equivalent transformations
Art scheme should all be fallen within the scope and spirit of the invention.
Claims (10)
1. a kind of portable multi-channel chromatographic apparatus, characterized in that it comprises:
Liquid reserve tank, for accommodating sample liquid；
Reaction chamber is set to below the liquid reserve tank, and the reaction chamber includes at least two mutually independent sense channels；
Switching mechanism is set between the liquid reserve tank and reaction chamber, for controlling each sense channel phase of the liquid reserve tank with reaction chamber
Connection or cut-off；
Testing agency, including shell and the multiple test strips being parallel to each other being set in the housing；The testing agency is set to institute
It states above reaction chamber, the testing agency is slidably connected with the liquid reserve tank, and the testing agency is along the liquid storage box outer wall
It moves up and down, so that the sample pad of the test strips is contacted or separated with the sample liquid being passed in each sense channel of reaction chamber.
2. portable multi-channel chromatographic apparatus as described in claim 1, which is characterized in that be provided with longitudinal direction in the reaction chamber
The inner cavity of partition, the reaction chamber is divided into multiple mutually independent sense channels by longitudinal baffle；The top of the reaction chamber
The position of corresponding each sense channel is equipped with test strips socket and injection port, the position of each test strips socket and every test paper
Item is corresponding, and the injection port is connected by the switching mechanism with the liquid reserve tank.
3. portable multi-channel chromatographic apparatus as described in claim 1, which is characterized in that the switching mechanism includes being fixedly arranged on
The sleeve of bottom and activity are inserted in the guide rod in the sleeve in the liquid reserve tank；The sleeve is equipped with several group patterns
The first through hole through the sleeve of arrangement, the guide rod are equipped with the several groups display arrangement of the corresponding first through hole
Second through-hole；The guide rod relative sleeve has first position and the second position, described when the guide rod is located at first position
First through hole is mutually aligned with the second through-hole and is connected to, and forms fluid passage and liquid reserve tank is connected with each sense channel of reaction chamber
It is logical；When the guide rod is located at the second position, the first through hole and the second through-hole mutually stagger and first through hole are closed,
So that each sense channel of liquid reserve tank and reaction chamber ends.
4. portable multi-channel chromatographic apparatus as claimed in claim 3, which is characterized in that the guide rod is rotationally inserted in
In the sleeve, the guide rod make when being rotated relative to the sleeve first through hole be mutually aligned with the second through-hole be connected to or
It mutually staggers, the side of the guide rod, which is equipped with, can drive the guide rod to rotate between the first position and the second position in sleeve
Knob；Alternatively, being provided with spring in the sleeve, one end and the guide rod side of spring are fixed, the other end and the sleeve one
Side is fixed, spring-compressed or reset when drive the guide rod along sleeve axis direction slide, make the first through hole and second
Through-hole is mutually aligned connection or mutually staggers.
5. portable multi-channel chromatographic apparatus as described in claim 1, which is characterized in that further include for limiting the shell
The limiting device of position.
6. portable multi-channel chromatographic apparatus as claimed in claim 5, which is characterized in that the two sides of the liquid reserve tank are equipped with
The L shape baffle extended to liquid reserve tank lateral direction, forms sliding slot between the L shape baffle and liquid reserve tank, the testing agency
Shell is slidably mounted in the sliding slot；It is provided with limiting slot on the L shape baffle, is set to card on the shell of the detection structure
Button, the limiting slot is by limiting the positions of test strips in the shell with described snap connection.
7. portable multi-channel chromatographic apparatus as claimed in claim 2, which is characterized in that the top of the reaction chamber, which is equipped with, to be used
In the sealing element for sealing reaction chamber opening；The sealing element includes the sealing film for sealing test strips socket, the testing agency
Shell lower end is equipped with the lancing device for being used to puncture the sealing film.
8. portable multi-channel chromatographic apparatus as described in claim 1, which is characterized in that be equipped at least two in the shell
Holding tank, the holding tank is arranged in parallel, and the test strips are placed in corresponding holding tank, the sample pad of the test strips
It stretches out in outside shell and forms extension, the observation window for observing test strips testing result, Huo Zhesuo are provided on the shell
It is transparent for stating shell.
9. portable multi-channel chromatographic apparatus as described in claim 1, which is characterized in that the test strips are immunity-chromatography test
Paper slip, the immuno-chromatographic test paper strip include bottom plate, are successively overlapped with sample pad, layer by chromatography direction on the bottom plate side
Film, water absorption pad are analysed, the chromatographic film is equipped with detection line corresponding with determinand and nature controlling line；The detection of the reaction chamber
The antibody marker of determinand or the antigenic label of determinand are fixed in channel；The antibody marker of the determinand be to
Survey the block of the antibody-marker object conjugate of object；The antigenic label of the determinand is the antigen-carrier egg of determinand
The block of white-marker conjugate；The antibody of determinand or the antigen-carrier egg of determinand are coated in the detection line
White conjugate is coated with goat anti-rabbit igg antibody or sheep anti-mouse igg antibody on the nature controlling line；The marker is band color
Grain or fluorescent nano particle or magnetic-particle.
10. portable multi-channel chromatographic apparatus as claimed in claim 4, which is characterized in that the top of the liquid reserve tank is arranged
There is liquid injection port, the liquid injection port is sealed with lid；The test strips socket, the injection port, the first through hole, described second
Through-hole is identical with the quantity of the test strips, is 4-8.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910152207.3A CN109669038A (en) | 2019-02-28 | 2019-02-28 | A kind of portable multi-channel chromatographic apparatus |
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| CN201910152207.3A CN109669038A (en) | 2019-02-28 | 2019-02-28 | A kind of portable multi-channel chromatographic apparatus |
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| CN110720482A (en) * | 2019-10-25 | 2020-01-24 | 马鞍山市春晖食品有限责任公司 | Food slip casting machine |
| CN111337297A (en) * | 2020-03-07 | 2020-06-26 | 成都佳仕得科技有限公司 | Proppant sampling device |
| CN113009137A (en) * | 2021-03-12 | 2021-06-22 | 齐鲁工业大学 | Test strip, detection test paper box and application thereof |
| CN113049813A (en) * | 2021-03-18 | 2021-06-29 | 中国人民解放军陆军军医大学第二附属医院 | Closed self-checking device for gastrointestinal occult blood |
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