CN109669037A - A kind of Seperated multiple channel chromatographic apparatus - Google Patents
A kind of Seperated multiple channel chromatographic apparatus Download PDFInfo
- Publication number
- CN109669037A CN109669037A CN201910151086.0A CN201910151086A CN109669037A CN 109669037 A CN109669037 A CN 109669037A CN 201910151086 A CN201910151086 A CN 201910151086A CN 109669037 A CN109669037 A CN 109669037A
- Authority
- CN
- China
- Prior art keywords
- cylindrical body
- reaction chamber
- test strips
- determinand
- air bag
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000012360 testing method Methods 0.000 claims abstract description 136
- 238000006243 chemical reaction Methods 0.000 claims abstract description 78
- 239000007788 liquid Substances 0.000 claims abstract description 60
- 238000001514 detection method Methods 0.000 claims abstract description 48
- 238000009434 installation Methods 0.000 claims abstract description 24
- 239000003550 marker Substances 0.000 claims description 29
- 238000004587 chromatography analysis Methods 0.000 claims description 19
- 230000007246 mechanism Effects 0.000 claims description 18
- 238000010521 absorption reaction Methods 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 230000000890 antigenic effect Effects 0.000 claims description 12
- 210000002421 cell wall Anatomy 0.000 claims description 9
- 238000003491 array Methods 0.000 claims description 6
- 241000283707 Capra Species 0.000 claims description 5
- 241001494479 Pecora Species 0.000 claims description 5
- 239000002105 nanoparticle Substances 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 238000007689 inspection Methods 0.000 claims description 3
- 230000006978 adaptation Effects 0.000 claims description 2
- 239000006249 magnetic particle Substances 0.000 claims description 2
- 239000000126 substance Substances 0.000 abstract description 16
- 238000009826 distribution Methods 0.000 abstract description 4
- 238000000034 method Methods 0.000 description 14
- 238000003317 immunochromatography Methods 0.000 description 7
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- REDXJYDRNCIFBQ-UHFFFAOYSA-N aluminium(3+) Chemical compound [Al+3] REDXJYDRNCIFBQ-UHFFFAOYSA-N 0.000 description 3
- 238000005452 bending Methods 0.000 description 3
- 125000004122 cyclic group Chemical group 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000001360 synchronised effect Effects 0.000 description 2
- 239000005725 8-Hydroxyquinoline Substances 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000005213 imbibition Methods 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 230000005389 magnetism Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 229960003540 oxyquinoline Drugs 0.000 description 1
- 229920006267 polyester film Polymers 0.000 description 1
- 239000002096 quantum dot Substances 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a kind of Seperated multiple channel chromatographic apparatus, comprising: quantitative siphoning installation is used for pipette samples liquid；Testing agency, is sheathed on the outside of the quantitative siphoning installation, the first cylindrical body including both ends open, and the lateral wall of first cylindrical body is equipped with multiple test strips of array arrangement；Second cylindrical body, the testing agency are slideably plugged in second cylindrical body, and second cylindrical body lower end is equipped with multiple connection through-holes of the corresponding quantity tube and test strips；The lower end of reaction chamber, including at least two mutually independent reactive tanks, the upper end of the reaction chamber and second cylindrical body, which rotates, to be connected.The detection of plurality of target detectable substance can be realized in primary sample-adding, solve the problems, such as that the distribution of sample liquid present in joint-detection is uneven and distribution is difficult to control, multinomial detection can stable progress simultaneously, realize high-throughput detection, testing staff's workload is effectively reduced, detection efficiency is improved.
Description
Technical field
The present invention relates to technical field of biological, more particularly to a kind of Seperated multiple channel chromatographic apparatus.
Background technique
Chromatographing detection to be is being in recent years a kind of important field quick detection form, because convenient, fast in clinical, food peace
Entirely, very popular in the fields such as environment measuring.Currently, chromatography usually needs to apply multiple test strips more to simple sample progress
A Indexs measure.When detection, it is common practice that sample liquid is placed in a public cavity, is then put into test strips,
Specific time reads result.Such way is only applicable to the chromatography of one-step method, can not be compatible with two-step method.And public chamber is to ring
The demanding detection process in border can generate pollution, be unable to satisfy such as nucleic acid detection project.Other methods are to pass through individual flow
Road enters each independent chromatography reaction chamber to the separating liquid in public chamber, then closes to runner, to realize layer
Analyse the interval of reaction process.But this way is only applicable to the chromatography reaction of one-step method, then cannot achieve for two-step method.
Summary of the invention
In order to make up the defect of prior art, the present invention provides a kind of Seperated multiple channel chromatographic apparatus.
The technical problems to be solved by the invention are achieved by the following technical programs:
A kind of Seperated multiple channel chromatographic apparatus, comprising:
Quantitative siphoning installation is used for pipette samples liquid, including air bag, reservoir and two on the cell wall of the reservoir
Above quantity tube, one end of the quantity tube are connected to the reservoir, and the other end is provided with liquid sucting port；The air bag with it is described
It is connected between reservoir；
Testing agency, is sheathed on the outside of the quantitative siphoning installation, the first cylindrical body including both ends open, and described first
The lateral wall of shape body is equipped with multiple test strips of array arrangement；
Second cylindrical body, the testing agency is slideably plugged in second cylindrical body, so as in the second cylindrical body
It slides along the vertical direction, the second cylindrical body upper end opening, lower end is equipped with multiple companies of the corresponding quantity tube and test strips
Connect hole；
Under reaction chamber, including at least two mutually independent reactive tanks, the upper end of the reaction chamber and second cylindrical body
End rotation connection；The reaction chamber has a first position and a second position relative to the second cylindrical body, when reaction chamber is located at
When first position, the reactive tank is mutually aligned with the connection through-hole and is connected to；It is described anti-when reaction chamber is located at the second position
It answers slot and the connection through-hole to mutually stagger and closes the reactive tank.
Further, it is connected between the reaction chamber and the second cylindrical body by screw thread rotation.
Specifically, the lateral wall of second cylindrical body is equipped with external screw thread, the upper end of the reaction chamber be equipped with it is described
The internal screw thread of external screw thread adaptation.
Further, second cylindrical body is connected with reaction chamber by buckle.
Specifically, the lower end of second cylindrical body is equipped with grab, and the reaction chamber is equipped with the card slot for being adapted to the buckle.
Further, the lateral wall of first cylindrical body is equipped with the holding tank of at least two strip arrays arrangement, the examination
Paper slip is placed in corresponding holding tank, and the sample pad of the test strips, which stretches out in outside the first cylindrical body, forms extension.
It further, further include position-limit mechanism；The testing agency relative to the second cylindrical body have a third place and
One the 4th position, the sample in test strips and the reactive tank when testing agency is located at the third place, in the testing agency
The separation of product liquid；When testing agency is located at four positions, the sample pad of the test strips in the testing agency passes through the connection
Through-hole is contacted with the sample liquid in reactive tank；The position-limit mechanism is used to the testing agency being separately fixed at the third position
It sets and the 4th position.
Further, the position-limit mechanism include at least two elastic bumps for being set to the first cylindrical body outer wall,
With the first annular ditch groove and the second annular ditch groove being adapted to the elastic bumps for being set to the second cylindrical body inner wall, institute
It states the first annular ditch groove to be arranged corresponding to the third place, second annular ditch groove is arranged corresponding to the 4th position.
Further, first cylindrical body, the second cylindrical body are transparent.
Further, the air bag is set to the top of the reservoir, one end of the air bag by connecting tube with it is described
It is connected between reservoir；One end of the quantity tube is connected to by bridge piece with the reservoir, the quantity tube with it is described
Angle between bridge piece is at 45 degree or less；The volume of the air bag is greater than the sum of the volume of each quantity tube.
Further, the test strips are immuno-chromatographic test paper strip, and the immuno-chromatographic test paper strip includes bottom plate, described
It is successively overlapped with sample pad, chromatographic film, water absorption pad by chromatography direction on bottom plate side, the chromatographic film is equipped with and determinand phase
Corresponding detection line and nature controlling line；The antibody marker or determinand of determinand are fixed in the reactive tank of the reaction chamber
Antigenic label；The antibody marker of the determinand is the block of the antibody-marker object conjugate of determinand；It is described to be measured
The antigenic label of object is antigen-carrier albumen-marker conjugate block of determinand；It is coated in the detection line
The antibody of determinand or the antigen-carrier protein conjugate of determinand, be coated on the nature controlling line goat anti-rabbit igg antibody or
Sheep anti-mouse igg antibody；The marker is band colored particle or fluorescent nano particle or magnetic-particle.
Further, the test strips are chemical detection test strips, and the chemical detection test strips include bottom plate, described
It is successively overlapped with sample pad, chromatographic film, water absorption pad by chromatography direction on bottom plate side, chemical examination is evenly equipped in the chromatographic film
With the determinand in sample liquid color change after specific chemical reacts occurs for agent, the chemical reagent.
Further, the squeeze buttons for squeezing the air bag are installed on the air bag.
Further, the quantity tube, holding tank, connection through-hole are identical with the quantity of reactive tank, are 2-8.
The invention has the following beneficial effects:
Quantitative siphoning installation of the invention is ingenious in design, is inhaled by extruding gasbag with siphon principle using reservoir and air bag
Take liquid into quantity tube, the liquid of extra quantity tube volume can flow in reservoir automatically, it is ensured that quantitative accuracy,
Without watching graduation mark attentively, singlehanded achievable quantitative liquid is pipetted, easy to operate, quick.
In the present invention, multiple test strips are set on the lateral wall of the first cylindrical body, and the first cylindrical body is inserted in second
Within shape body, can be avoided storage, transport and using when test strips be contaminated, operate it is more convenient.
Quantitative siphoning installation structure novel of the invention is equipped with multiple quantity tubes, using multi-pass on the cell wall of reservoir
Road is in parallel, and quantitative siphoning installation is separably set within first cylindrical body, and when sample-adding, quantitative siphoning installation is inserted in
Within first cylindrical body, the connection through-hole that each quantity tube passes through the second cylindrical body lower end is connected to each reactive tank, can be synchronized
Sample liquid is assigned in each reactive tank evenly, mean allocation sample-adding amount is realized, improves the accuracy of sample-adding, carrying side
Just, quantitative accurate, conventional efficient can be effectively improved；After sample-adding, quantitative siphoning installation is taken out within the first cylindrical body
, quantitatively it is loaded simple to operate.
Second cylindrical body upper end opening of the invention, lower end is equipped with the corresponding quantity tube and multiple connections of test strips are logical
Hole；Reaction chamber includes at least two mutually independent reactive tanks, the lower end of the upper end of the reaction chamber and second cylindrical body
Rotation connection, reaction chamber is opened in rotary course or capping slot；The independent reaction chromatographed in each reactive tank can satisfy
The demand of environmentally sensitive type test, can be avoided cross-infection, guarantees the accuracy of testing result；Primary sample-adding can be realized
The detection of plurality of target detectable substance solves the problems, such as that the distribution of sample liquid present in joint-detection is uneven and distribution is difficult to control,
Multinomial detection can stable progress simultaneously, realize high-throughput detection, effectively reduce testing staff's workload, improve detection
Efficiency.
Testing agency of the invention is slideably plugged in second cylindrical body, so as in the second cylindrical body along perpendicular
Histogram is to sliding, so that the sample pad of the test strips is contacted or separated with the sample liquid being passed in each reactive tank of reaction chamber.
By this set, the detection of the test strips of two-step method not only may be implemented, moreover, if the sample liquid in reactive tank needs to mix
It is even, the reaction chamber can be rocked manually, test strips will not be polluted, adjacent reaction hole will not be interfered, and had highly sensitive, high
Specificity uses the features such as simple and direct, low in cost.
It using the detection that chromatographic apparatus of the invention carries out is carried out in the system of a relative closure, also in certain journey
A possibility that reducing sample contamination and detection pollution on degree, the stability of detection is further improved, artificial behaviour is decreased
Make the hidden danger of error.
In the present invention, according to actually detected demand, the test strips of detection different material can be selected to combine with reaction tank, it is full
Sufficient different demands.
It in the present invention, after the completion of test strips detection, arranges uniform, easily can accurately be read in readout instrument reading
It takes, without being one by one aligned test strips, reduces error.
Detailed description of the invention
Fig. 1 is structure chart of the invention；
Fig. 2 is the perspective view of the quantitative siphoning installation of the present invention；
Fig. 3 is the perspective view of reaction chamber of the present invention.
In figure: 1, air bag, 2, reservoir, 3, quantity tube, 4, connecting tube, 5, bridge piece, 6, squeeze buttons, 7, first
Shape body, 8, test strips, the 9, second cylindrical body, 10, reaction chamber, 11, grab, 12, reactive tank, 13, card slot, 14, screw thread.
Specific embodiment
A kind of Seperated multiple channel chromatographic apparatus, including quantitative siphoning installation, testing agency, the second cylindrical body and reaction
Chamber.
The quantitative siphoning installation, into reaction chamber, including air bag, reservoir and is set to the storage for pipette samples liquid
More than two quantity tubes on the cell wall of liquid bath, one end of the quantity tube are connected to the reservoir, and the other end is provided with suction
Liquid mouth；It is connected between the air bag and the reservoir.
Preferably, the air bag is set to the top of the reservoir, and the quantity tube and the reservoir are arranged in parallel, institute
The top for stating quantity tube is lower than the most significant end of the reservoir, and the top of the quantity tube is connected with the inside of the reservoir
Logical, the bottom end of the quantity tube is provided with liquid sucting port, and the liquid sucting port exceeds the lowermost end of the reservoir.
Preferably, the quantity tube annular array is on the cell wall of the reservoir.
In the present invention, the number of quantity tube is not limited specifically, preferably, the quantity of the quantity tube is 2-8, example
It such as can be 6.The present invention, using Multi-channel parallel connection, can be synchronized by the way that multiple quantity tubes are arranged on the cell wall of reservoir
Equably sample liquid is assigned in each reactive tank, mean allocation sample-adding amount is realized, improves the accuracy of sample-adding, carrying side
Just, quantitative accurate, conventional efficient can be effectively improved.
The side wall of the quantity tube is equipped with graduation mark.By this set, enable the operator to select as needed
Suitable quantity tube is not easy to mix up convenient for identification.
One end of the air bag between connecting tube and the reservoir by being connected to.It specifically, further include connecting tube, it is described
The top that one end of connecting tube is fixedly connected with the other end and the reservoir of the connecting tube with the lower end of the air bag is fixed
Connection, is connected between the air bag, connecting tube and reservoir.
One end of the quantity tube is connected to by bridge piece with the reservoir.The quantity tube and the bridge piece
In the bending with a bending angle, and the bending angle is at an acute angle.Preferably, between the quantity tube and the bridge piece
Angle at 45 degree or less.In the present invention, quantity tube is arranged at an angle with bridge piece, and in imbibition, liquid exists first
It is not easily accessed reservoir when filling quantity tube, avoids error.And after filling, air bag is unclamped, liquid again can be along even
It connects bend pipe and smoothly enters reservoir.
Squeeze buttons for squeezing the air bag are installed on the air bag.
In the present invention, squeeze buttons are pressed, makes air bag tightening, exhaust, reduces air pressure.In the present invention, by air bag
Squeeze buttons are set, and the stability of extruding gasbag is good, and different people can be made almost the same to the extruding of air bag, avoids because a
The body finger amount of different sizes for causing pressurization is different, and extruding efficiency is high, and more beautiful.
Supporting element can be equipped between the quantity tube and the reservoir.By this set, mentioned for entire quantity tube
For a rigid support, enhance the intensity of quantity tube, while also facilitating hand-held siphoning installation operation；Difficulty drops when production technology
It is low.
In the present invention, the supporting element is made of hard material, and can not be plastics, metal, glass as an example, but not
It is limited to this.
Air bag is the hollow elastic ball being integrated into waterproof soft material, as an example, the material of the air bag
It can be plastics, but not limited to this.
The present invention does not also limit the shape of air bag specifically, and as an example, the air bag can be spherical shape, or ellipse
Spherical shape.
The size of the air bag is set according to the size and number of quantity tube, it is preferable that the volume of the air bag is greater than
The sum of the volume of each quantity tube.It by this set, ensure that primary by pressuring gasbag, quantity tube can be filled liquid.
In the present invention, the shape of the reservoir can be elliposoidal, or spherical.
The testing agency is sheathed on the outside of the quantitative siphoning installation, the first cylindrical body including both ends open, institute
The lateral wall for stating the first cylindrical body is equipped with multiple test strips of array arrangement.
In the present invention, test strips are not limited specifically, the mode in the first cylindrical body is set, as long as making test strips easy
In fixation and taking-up.Preferably, the lateral wall of first cylindrical body is equipped at least two annular arrays
Holding tank, the test strips are placed in corresponding holding tank, and the sample pad of the test strips is stretched out in outside the first cylindrical body and formed
Extension.
The testing agency is slideably plugged in second cylindrical body, so as in the second cylindrical body along vertical side
To sliding, the second cylindrical body upper end opening, lower end is equipped with several connection through-holes, and the position of each connection through-hole corresponds to institute
State quantity tube and test strips.
The reaction chamber includes at least two mutually independent reactive tanks, each reactive tank annular array；The reaction
The upper end of chamber and the lower end of second cylindrical body, which rotate, to be connected；The reaction chamber has one first relative to the second cylindrical body
Set with a second position, when reaction chamber is located at first position, the reactive tank is mutually aligned with the connection through-hole and is connected to；When
When reaction chamber is located at the second position, the reactive tank and the connection through-hole mutually stagger and close the reactive tank.
In the present invention, the mode of the rotation connection is not limited specifically, can use the various modes of this field routine
It realizes, preferably, being connected between the reaction chamber and the second cylindrical body by screw thread rotation.Specifically, second tubular
The lateral wall of body is equipped with external screw thread, and the upper end of the reaction chamber is equipped with the internal screw thread being adapted to the external screw thread.
Second cylindrical body is connected with reaction chamber by buckle.Specifically, the lower end of second cylindrical body is equipped with card
Hook, the reaction chamber are equipped with the card slot for being adapted to the grab.It by this set, turn reaction chamber can relative to the second cylindrical body
It moves and does not fall off.
It further include position-limit mechanism；The testing agency has a third place and one the 4th relative to the second cylindrical body
It sets, when testing agency is located at the third place, the test strips in the testing agency are separated with the sample liquid in the reactive tank；
When testing agency is located at four positions, the sample pads of the test strips in the testing agency pass through the connection through-hole with react
Sample liquid contact in slot；The position-limit mechanism is used to the testing agency being separately fixed at the third place and the 4th
It sets.
In actual use, the first cylindrical body is slided up and down along the second cylindrical body, position of the position-limit mechanism to the first cylindrical body
It migrates journey and plays the role of limit, when the first cylindrical body slides down to the third place, the test strips in the first cylindrical body are complete
It is placed in the second cylindrical body entirely, test strips are not contacted with the sample liquid in the reactive tank；When the first cylindrical body of pushing to the 4th
When position, it was demonstrated that the first cylindrical body is moved to lower limit, and the sample pad of test strips passes through the sample in the connection through-hole and reactive tank
The contact of product liquid ensure that the mobile position precision of the first cylindrical body, so that the test strips in the first cylindrical body will not be excessively pushed into
Test strips are caused to fracture in reactive tank.
It to achieve the goals above, can be using various known position-limit mechanisms in the prior art, preferably, the limit
Position mechanism includes being set at least two elastic bumps of the first cylindrical body outer wall and being set in second cylindrical body
The first annular ditch groove and the second annular ditch groove that are adapted to the elastic bumps of wall, first annular ditch groove correspond to described
The third place setting, second annular ditch groove are arranged corresponding to the 4th position.
For the ease of observation, first cylindrical body, the second cylindrical body are transparent.
Chromatographic apparatus of the invention can be used for chemical detection, and the test strips are chemical detection test strips, the chemistry
Test strip includes bottom plate, is successively overlapped with sample pad, chromatographic film, water absorption pad by chromatography direction on the bottom plate side,
Chemical reagent is evenly equipped in the chromatographic film, after the chemical reagent is reacted with the determinand generation specific chemical in sample liquid
Color change.
As an example, when the determinand in sample liquid is aluminium ion, 8- Hydroxy-quinolin, chemistry inspection are evenly equipped in chromatographic film
Test paper slip in sample pad contact with sample liquid carry out chromatograph react when, if containing aluminium ion in sample liquid, aluminium ion is through layer
8-hydroxyquinoline in analysis effect and chromatographic film plays high specific chemical reaction, so that chromatographic film is become yellow from colourless, to reach
To the purpose quickly detected.
Chromatographic apparatus of the invention can be also used for immune detection, and the test strips are immuno-chromatographic test paper strip.
When chromatographic apparatus of the invention is used for immune detection, it can be used for the immunochromatography of one-step method, can be used for two
The immunochromatography of footwork.
When chromatographic apparatus of the invention is used for the immunochromatography of one-step method, the test strips include bottom plate, at the bottom
On plate side by chromatography direction be successively overlapped with sample pad, bonding pad, chromatographic film, water absorption pad, be fixed on the bonding pad to
Survey the antibody marker of object or the antigenic label of determinand；The chromatographic film be equipped with detection line corresponding with determinand with
And nature controlling line.
When chromatographic apparatus of the invention is used for the immunochromatography of two-step method, the test strips include bottom plate, at the bottom
It is successively overlapped with sample pad, chromatographic film, water absorption pad by chromatography direction on plate side, the chromatographic film is equipped with opposite with determinand
The detection line and nature controlling line answered.Specifically, the test strips include bottom plate, sample pad, chromatographic film, water absorption pad, the bottom plate
Side is equipped with sample pad, and the other side is equipped with water absorption pad, and chromatographic film, neighboring samples pad and chromatography are equipped between sample pad and water absorption pad
For film in the overlapping connection in junction, the chromatographic film and water absorption pad in the overlapping connection in junction, the middle part of chromatographic film is equipped with detection line
And nature controlling line, for detection line close to sample pad, the sample pad of the test strips, which stretches out in outside the first cylindrical body, forms extension；It is described
The antibody marker of determinand or the antigenic label of determinand are fixed in the reactive tank of reaction chamber.
Marker conjugate coated in existing bonding pad is set in reactive tank by the immunochromatography of two-step method, so that its
It is first more fully reacted with the analyte sample fluid in reactive tank, improves and react not thorough in traditional test strip on bonding pad
It not exclusively the defects of low efficiency, so that determinand thoroughly reacts in homogeneous system with marker conjugate, improves sensitive at bottom
Degree.
The sample pad is polyester film, glass or filter paper with sample filtering function.
The water absorption pad is blotting paper；The chromatographic film is nitrocellulose filter or cellulose acetate film.
The marker be can be used to identify and detect acquisition signal substance, such as band colored particle, such as colloidal gold, but
It is not limited to this, as an example, it can also be latex, fluorescent nano particle, quantum dot or up-conversion luminescence substance etc..The present invention
It not only can satisfy the testing requirements of fast qualitative, Effective judgement can also be carried out to sample result and sample amounts are analyzed.
The antibody marker of the determinand is the block of the antibody-marker object conjugate of determinand；The determinand
Antigenic label be determinand antigen-carrier albumen-marker conjugate block；Be coated in the detection line to
The antibody of object or the antigen-carrier protein conjugate of determinand are surveyed, is coated with goat anti-rabbit igg antibody or sheep on the nature controlling line
Dynamics.
When carrying out immunochromatography using two-step method, detection method of the invention is: (1) sample is acquired, at sample
Reason obtains sample liquid；(2) be loaded: first extruding gasbag, in the case where external force pinches pressure effect, the air bag can be deflated and will be in air bag
Air discharge；Then the liquid sucting port of quantity tube is put in the sample liquid to be pipetted, come up air bag, after external force revocation
Air bag restores to the original state automatically and is drawn into sample liquid in each quantity tube under siphon principle effect, when the liquid drawn in quantity tube
When body is higher than its top, it can flow in reservoir automatically, make accurately to draw quantitative liquid in quantity tube；Then, revolving reaction
Chamber, so that reaction chamber is located at first position, the reactive tank is mutually aligned with the connection through-hole and is connected to；First cylindrical body is inserted
Enter into the second cylindrical body, the first cylindrical body is made to slide down to the third place, the test strips in the first cylindrical body are completely disposed at
In second cylindrical body, test strips are not contacted with the sample liquid in the reactive tank；Quantitative siphoning installation is inserted into testing agency
The first cylindrical body in, each quantity tube pass through the second cylindrical body lower end connection through-hole be connected to each reactive tank, extruding gasbag, to
Quantitative sample liquid is added in each reactive tank；Take out quantitative siphoning installation；(3) it detects: revolving reaction chamber, so that reaction chamber is located at
When the second position, the reactive tank and the connection through-hole mutually stagger and close the reactive tank, rock chromatographic apparatus, make
The determinand obtained in sample liquid is first anti-with the antigenic label of the antibody marker of determinand fixed in reactive tank or determinand
It answers, after reaction, revolving reaction chamber, so that reaction chamber is located at first position, the reactive tank and the connection through-hole are mutual
Alignment connection, when pushing the first cylindrical body to four positions, the sample pad of test strips is passed through in the connection through-hole and reactive tank
Sample liquid contact carry out immunochromatography reaction, visually observe or instrument scanning chromatographic film on each detection line signal power,
Determine the number of respective objects substance in sample, the content of respective objects substance is also higher in signal more weak sample.Entire inspection
Survey process is carried out in two steps, i.e., immune combination and Immune competition, due to this feature, so reaction is sufficiently, and sensitive raising, operation
Simplicity, detection are specific antigen-antibody reactions, so having the characteristics that high specificity, accuracy are high.
In the present invention, the quantity tube, holding tank, connection through-hole are identical with the quantity of reactive tank, can be according to practical need
It is set, is preferably all 2-8, more preferably 4-6.
The present invention will now be described in detail with reference to examples, and the examples are only preferred embodiments of the present invention,
It is not limitation of the invention.
Embodiment 1
A kind of Seperated multiple channel chromatographic apparatus, comprising:
Quantitative siphoning installation is used for pipette samples liquid, including air bag, reservoir and 6 on the cell wall of the reservoir
One end of quantity tube, the quantity tube is connected to by bridge piece with the reservoir, the quantity tube and the bridge piece
Between angle at 45 degree or less；The other end of the quantity tube is provided with liquid sucting port；One end of the air bag by connecting tube with
It is connected between the reservoir；The air bag is set to the top of the reservoir, and the volume of the air bag is greater than each quantity tube
The sum of volume；Squeeze buttons for squeezing the air bag are installed on the air bag；
Testing agency, is sheathed on the outside of the quantitative siphoning installation, the first cylindrical body including both ends open, and described first
The lateral wall of shape body is equipped with the holding tank of 6 strip arrays arrangement, and test strips are placed in corresponding holding tank, the sample of the test strips
Product pad, which stretches out in outside the first cylindrical body, forms extension；The test strips are immuno-chromatographic test paper strip, the immune chromatography test paper
Item includes bottom plate, is successively overlapped with sample pad, chromatographic film, water absorption pad, the chromatography by chromatography direction on the bottom plate side
Film is equipped with detection line corresponding with determinand and nature controlling line；The anti-of determinand is fixed in the reactive tank of the reaction chamber
The antigenic label of body marker or determinand；The antibody marker of the determinand is that the antibody-marker object of determinand is coupled
The block of object；The antigenic label of the determinand is antigen-carrier albumen-marker conjugate bulk of determinand
Object；The antibody of determinand or the antigen-carrier protein conjugate of determinand are coated in the detection line, on the nature controlling line
It is coated with goat anti-rabbit igg antibody or sheep anti-mouse igg antibody；The marker is band colored particle or fluorescent nano particle or magnetism
Particle；
Second cylindrical body, the testing agency is slideably plugged in second cylindrical body, so as in the second cylindrical body
It slides along the vertical direction, the second cylindrical body upper end opening, lower end is equipped with 6 connections of the corresponding quantity tube and test strips
Through-hole；
Reaction chamber, including 6 mutually independent reactive tanks, the upper end of the reaction chamber and the lower end of second cylindrical body pass through
Screw thread rotation connection；Second cylindrical body is connected with reaction chamber by buckle；The reaction chamber has relative to the second cylindrical body
There are a first position and a second position, when reaction chamber is located at first position, the reactive tank and the connection through-hole are mutual
Alignment connection；When reaction chamber is located at the second position, the reactive tank mutually staggers with the connection through-hole and makes described react
Slot closing；
Position-limit mechanism, the testing agency have a third place and one the 4th position relative to the second cylindrical body, work as detection machine
When structure is located at the third place, the test strips in the testing agency are separated with the sample liquid in the reactive tank；Work as testing agency
When positioned at four positions, the sample pad of the test strips in the testing agency passes through the sample in the connection through-hole and reactive tank
Liquid contact；The position-limit mechanism includes being set at least two elastic bumps of the first cylindrical body outer wall and being set to institute
The first annular ditch groove and the second annular ditch groove that are adapted to the elastic bumps of the second cylindrical body inner wall are stated, described first is cyclic annular
Groove is arranged corresponding to the third place, and second annular ditch groove is arranged corresponding to the 4th position；
First cylindrical body, the second cylindrical body are transparent.
Embodiment 2
A kind of Seperated multiple channel chromatographic apparatus, comprising:
Quantitative siphoning installation is used for pipette samples liquid, including air bag, reservoir and 4 on the cell wall of the reservoir
One end of quantity tube, the quantity tube is connected to by bridge piece with the reservoir, the quantity tube and the bridge piece
Between angle at 45 degree or less；The other end of the quantity tube is provided with liquid sucting port；One end of the air bag by connecting tube with
It is connected between the reservoir；The air bag is set to the top of the reservoir, and the volume of the air bag is greater than each quantity tube
The sum of volume；Squeeze buttons for squeezing the air bag are installed on the air bag；
Testing agency, is sheathed on the outside of the quantitative siphoning installation, the first cylindrical body including both ends open, and described first
The lateral wall of shape body is equipped with the holding tank of 4 strip arrays arrangement, and test strips are placed in corresponding holding tank, the sample of the test strips
Product pad, which stretches out in outside the first cylindrical body, forms extension；The test strips are immuno-chromatographic test paper strip, the immune chromatography test paper
Item includes bottom plate, is successively overlapped with sample pad, bonding pad, chromatographic film, water absorption pad, institute by chromatography direction on the bottom plate side
It states and is fixed with the antibody marker of determinand or the antigenic label of determinand on bonding pad；The chromatographic film be equipped with it is to be measured
The corresponding detection line of object and nature controlling line；The antibody marker of the determinand is the antibody-marker object conjugate of determinand
Block；The antigenic label of the determinand is antigen-carrier albumen-marker conjugate block of determinand；
It is coated with the antibody of determinand or the antigen-carrier protein conjugate of determinand in the detection line, is wrapped on the nature controlling line
There are goat anti-rabbit igg antibody or sheep anti-mouse igg antibody；The marker is colloidal gold or fluorescent nano particle；
Second cylindrical body, the testing agency is slideably plugged in second cylindrical body, so as in the second cylindrical body
It slides along the vertical direction, the second cylindrical body upper end opening, lower end is equipped with 4 connections of the corresponding quantity tube and test strips
Through-hole；
Reaction chamber, including 4 mutually independent reactive tanks, the upper end of the reaction chamber and the lower end of second cylindrical body pass through
Screw thread rotation connection；Second cylindrical body is connected with reaction chamber by buckle；The reaction chamber has relative to the second cylindrical body
There are a first position and a second position, when reaction chamber is located at first position, the reactive tank and the connection through-hole are mutual
Alignment connection；When reaction chamber is located at the second position, the reactive tank mutually staggers with the connection through-hole and makes described react
Slot closing；
Position-limit mechanism, the testing agency have a third place and one the 4th position relative to the second cylindrical body, work as detection machine
When structure is located at the third place, the test strips in the testing agency are separated with the sample liquid in the reactive tank；Work as testing agency
When positioned at four positions, the sample pad of the test strips in the testing agency passes through the sample in the connection through-hole and reactive tank
Liquid contact；The position-limit mechanism includes being set at least two elastic bumps of the first cylindrical body outer wall and being set to institute
The first annular ditch groove and the second annular ditch groove that are adapted to the elastic bumps of the second cylindrical body inner wall are stated, described first is cyclic annular
Groove is arranged corresponding to the third place, and second annular ditch groove is arranged corresponding to the 4th position；
First cylindrical body, the second cylindrical body are transparent.
Embodiment 3
A kind of Seperated multiple channel chromatographic apparatus, comprising:
Quantitative siphoning installation is used for pipette samples liquid, including air bag, reservoir and 8 on the cell wall of the reservoir
One end of quantity tube, the quantity tube is connected to by bridge piece with the reservoir, the quantity tube and the bridge piece
Between angle at 45 degree or less；The other end of the quantity tube is provided with liquid sucting port；One end of the air bag by connecting tube with
It is connected between the reservoir；The air bag is set to the top of the reservoir, and the volume of the air bag is greater than each quantity tube
The sum of volume；Squeeze buttons for squeezing the air bag are installed on the air bag；
Testing agency, is sheathed on the outside of the quantitative siphoning installation, the first cylindrical body including both ends open, and described first
The lateral wall of shape body is equipped with the holding tank of 8 strip arrays arrangement, and test strips are placed in corresponding holding tank, the sample of the test strips
Product pad, which stretches out in outside the first cylindrical body, forms extension；The test strips are chemical detection test strips, the chemical detection test paper
Item includes bottom plate, is successively overlapped with sample pad, chromatographic film, water absorption pad, the chromatography by chromatography direction on the bottom plate side
Chemical reagent is evenly equipped on film, the chemical reagent occurs color after specific chemical reacts with the determinand in sample liquid and becomes
Change；
Second cylindrical body, the testing agency is slideably plugged in second cylindrical body, so as in the second cylindrical body
It slides along the vertical direction, the second cylindrical body upper end opening, lower end is equipped with 8 connections of the corresponding quantity tube and test strips
Through-hole；
Reaction chamber, including 8 mutually independent reactive tanks, the upper end of the reaction chamber and the lower end of second cylindrical body pass through
Screw thread rotation connection；Second cylindrical body is connected with reaction chamber by buckle；The reaction chamber has relative to the second cylindrical body
There are a first position and a second position, when reaction chamber is located at first position, the reactive tank and the connection through-hole are mutual
Alignment connection；When reaction chamber is located at the second position, the reactive tank mutually staggers with the connection through-hole and makes described react
Slot closing；
Position-limit mechanism, the testing agency have a third place and one the 4th position relative to the second cylindrical body, work as detection machine
When structure is located at the third place, the test strips in the testing agency are separated with the sample liquid in the reactive tank；Work as testing agency
When positioned at four positions, the sample pad of the test strips in the testing agency passes through the sample in the connection through-hole and reactive tank
Liquid contact；The position-limit mechanism includes being set at least two elastic bumps of the first cylindrical body outer wall and being set to institute
The first annular ditch groove and the second annular ditch groove that are adapted to the elastic bumps of the second cylindrical body inner wall are stated, described first is cyclic annular
Groove is arranged corresponding to the third place, and second annular ditch groove is arranged corresponding to the 4th position；
First cylindrical body, the second cylindrical body are transparent.
Embodiments of the present invention above described embodiment only expresses, the description thereof is more specific and detailed, but can not
Therefore limitations on the scope of the patent of the present invention are interpreted as, as long as skill obtained in the form of equivalent substitutions or equivalent transformations
Art scheme should all be fallen within the scope and spirit of the invention.
Claims (10)
1. a kind of Seperated multiple channel chromatographic apparatus, characterized in that it comprises:
Quantitative siphoning installation is used for pipette samples liquid, including air bag, reservoir and two on the cell wall of the reservoir
Above quantity tube, one end of the quantity tube are connected to the reservoir, and the other end is provided with liquid sucting port；The air bag with it is described
It is connected between reservoir；
Testing agency, is sheathed on the outside of the quantitative siphoning installation, the first cylindrical body including both ends open, and described first
The lateral wall of shape body is equipped with multiple test strips of array arrangement；
Second cylindrical body, the testing agency is slideably plugged in second cylindrical body, so as in the second cylindrical body
It slides along the vertical direction, the second cylindrical body upper end opening, lower end is equipped with multiple companies of the corresponding quantity tube and test strips
Connect hole；
Under reaction chamber, including at least two mutually independent reactive tanks, the upper end of the reaction chamber and second cylindrical body
End rotation connection；The reaction chamber has a first position and a second position relative to the second cylindrical body, when reaction chamber is located at
When first position, the reactive tank is mutually aligned with the connection through-hole and is connected to；It is described anti-when reaction chamber is located at the second position
It answers slot and the connection through-hole to mutually stagger and closes the reactive tank.
2. Seperated multiple channel chromatographic apparatus as described in claim 1, which is characterized in that the reaction chamber and the second cylindrical body
Between pass through screw thread rotation connect.
3. Seperated multiple channel chromatographic apparatus as described in claim 1, which is characterized in that second cylindrical body and reaction chamber
It is connected by buckling.
4. Seperated multiple channel chromatographic apparatus as described in claim 1, which is characterized in that the lateral wall of first cylindrical body
It is equipped with the holding tank of at least two strip arrays arrangement, the test strips are placed in corresponding holding tank, the sample of the test strips
Pad, which stretches out in outside the first cylindrical body, forms extension.
5. Seperated multiple channel chromatographic apparatus as described in claim 1, which is characterized in that further include position-limit mechanism；The inspection
Surveying mechanism has a third place and one the 4th position, when testing agency is located at the third place, institute relative to the second cylindrical body
The test strips stated in testing agency are separated with the sample liquid in the reactive tank；It is described when testing agency is located at four positions
The sample pad of test strips in testing agency passes through the connection through-hole and contacts with the sample liquid in reactive tank；The position-limit mechanism
For the testing agency to be separately fixed at the third place and the 4th position.
6. Seperated multiple channel chromatographic apparatus as claimed in claim 5, which is characterized in that the position-limit mechanism includes being set to
At least two elastic bumps of the first cylindrical body outer wall and it is set to the convex with the elasticity of the second cylindrical body inner wall
The first annular ditch groove and the second annular ditch groove of adaptation are played, first annular ditch groove is arranged corresponding to the third place, institute
The second annular ditch groove is stated to be arranged corresponding to the 4th position.
7. Seperated multiple channel chromatographic apparatus as described in claim 1, which is characterized in that the air bag is set to the reservoir
Top, one end of the air bag between connecting tube and the reservoir by being connected to；One end of the quantity tube passes through connection
Bend pipe is connected to the reservoir, and the angle between the quantity tube and the bridge piece is at 45 degree or less；The air bag
Volume is greater than the sum of the volume of each quantity tube.
8. Seperated multiple channel chromatographic apparatus as described in claim 1, which is characterized in that the test strips are immunity-chromatography test
Paper slip, the immuno-chromatographic test paper strip include bottom plate, are successively overlapped with sample pad, layer by chromatography direction on the bottom plate side
Film, water absorption pad are analysed, the chromatographic film is equipped with detection line corresponding with determinand and nature controlling line；The reaction of the reaction chamber
The antibody marker of determinand or the antigenic label of determinand are fixed in slot；The antibody marker of the determinand is to be measured
The block of the antibody-marker object conjugate of object；The antigenic label of the determinand is the antigen-carrier albumen-of determinand
The block of marker conjugate；The antibody of determinand or the antigen-carrier albumen of determinand are coated in the detection line
Conjugate is coated with goat anti-rabbit igg antibody or sheep anti-mouse igg antibody on the nature controlling line；The marker is band colored particle
Or fluorescent nano particle or magnetic-particle.
9. Seperated multiple channel chromatographic apparatus as described in claim 1, which is characterized in that be equipped on the air bag for squeezing
Press the squeeze buttons of the air bag；First cylindrical body, the second cylindrical body are transparent.
10. Seperated multiple channel chromatographic apparatus as described in claim 1, which is characterized in that the quantity tube, holding tank, company
It is identical with the quantity of reactive tank to connect hole, is 2-8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910151086.0A CN109669037B (en) | 2019-02-28 | 2019-02-28 | Separated multi-channel chromatographic device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910151086.0A CN109669037B (en) | 2019-02-28 | 2019-02-28 | Separated multi-channel chromatographic device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109669037A true CN109669037A (en) | 2019-04-23 |
| CN109669037B CN109669037B (en) | 2024-03-15 |
Family
ID=66152249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910151086.0A Active CN109669037B (en) | 2019-02-28 | 2019-02-28 | Separated multi-channel chromatographic device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109669037B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111707810A (en) * | 2020-05-11 | 2020-09-25 | 杭州博拓生物科技股份有限公司 | Sample detection device and application method thereof |
| CN113075176A (en) * | 2021-03-17 | 2021-07-06 | 西安医学院 | Tumor marker multi-analysis device |
| US20230075293A1 (en) * | 2021-09-06 | 2023-03-09 | China Agricultural University | Detection device using lateral flow strip for detection and detection method thereof |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN85104030A (en) * | 1984-05-11 | 1986-11-19 | 海布利德克公司 | Method of immunity and device |
| CN1688882A (en) * | 2002-10-22 | 2005-10-26 | 艾康实验室公司 | In line test device and methods of use |
| JP2009300433A (en) * | 2008-05-15 | 2009-12-24 | Toray Ind Inc | Analysis chip |
| CN101980021A (en) * | 2010-10-22 | 2011-02-23 | 南通市伊士生物技术有限责任公司 | Colloidal gold chromatography test strip for quickly detecting sibutramine and derivative thereof and preparation method |
| CN102539749A (en) * | 2012-02-16 | 2012-07-04 | 江阴康奈尔生物科技有限公司 | Field high-sensitivity immunoassay method and kit |
| CN206114672U (en) * | 2016-08-24 | 2017-04-19 | 北京市理化分析测试中心 | Novel immunity chromatography detect reagent box |
| US9632083B1 (en) * | 2016-04-15 | 2017-04-25 | Dnt Scientific Research, Llc | Rapid diagnostic test device by driven flow technology |
| WO2018068582A1 (en) * | 2016-10-10 | 2018-04-19 | 广州瑞博奥生物科技有限公司 | Immunochromatography detection apparatus |
| CN207336544U (en) * | 2017-12-06 | 2018-05-08 | 深圳市易瑞生物技术股份有限公司 | A kind of remaining immuno-chromatography detection device of high throughput agricultural and veterinary chemicals |
| CN209542626U (en) * | 2019-02-28 | 2019-10-25 | 深圳市易瑞生物技术股份有限公司 | A kind of Seperated multiple channel chromatographic apparatus |
-
2019
- 2019-02-28 CN CN201910151086.0A patent/CN109669037B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN85104030A (en) * | 1984-05-11 | 1986-11-19 | 海布利德克公司 | Method of immunity and device |
| CN1688882A (en) * | 2002-10-22 | 2005-10-26 | 艾康实验室公司 | In line test device and methods of use |
| JP2009300433A (en) * | 2008-05-15 | 2009-12-24 | Toray Ind Inc | Analysis chip |
| CN101980021A (en) * | 2010-10-22 | 2011-02-23 | 南通市伊士生物技术有限责任公司 | Colloidal gold chromatography test strip for quickly detecting sibutramine and derivative thereof and preparation method |
| CN102539749A (en) * | 2012-02-16 | 2012-07-04 | 江阴康奈尔生物科技有限公司 | Field high-sensitivity immunoassay method and kit |
| US9632083B1 (en) * | 2016-04-15 | 2017-04-25 | Dnt Scientific Research, Llc | Rapid diagnostic test device by driven flow technology |
| CN206114672U (en) * | 2016-08-24 | 2017-04-19 | 北京市理化分析测试中心 | Novel immunity chromatography detect reagent box |
| WO2018068582A1 (en) * | 2016-10-10 | 2018-04-19 | 广州瑞博奥生物科技有限公司 | Immunochromatography detection apparatus |
| CN207336544U (en) * | 2017-12-06 | 2018-05-08 | 深圳市易瑞生物技术股份有限公司 | A kind of remaining immuno-chromatography detection device of high throughput agricultural and veterinary chemicals |
| CN209542626U (en) * | 2019-02-28 | 2019-10-25 | 深圳市易瑞生物技术股份有限公司 | A kind of Seperated multiple channel chromatographic apparatus |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111707810A (en) * | 2020-05-11 | 2020-09-25 | 杭州博拓生物科技股份有限公司 | Sample detection device and application method thereof |
| CN113075176A (en) * | 2021-03-17 | 2021-07-06 | 西安医学院 | Tumor marker multi-analysis device |
| CN113075176B (en) * | 2021-03-17 | 2022-11-01 | 西安医学院 | Tumor marker multi-analysis device |
| US20230075293A1 (en) * | 2021-09-06 | 2023-03-09 | China Agricultural University | Detection device using lateral flow strip for detection and detection method thereof |
| US12031984B2 (en) * | 2021-09-06 | 2024-07-09 | China Agricultural University | Detection device using lateral flow strip for detection and detection method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109669037B (en) | 2024-03-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3299271B2 (en) | Capillary blood antigen tester | |
| JP2731613B2 (en) | Cartridge for enzyme immunoassay, measuring method and measuring apparatus using the same | |
| US5393496A (en) | Saliva sampling device and sample adequacy system | |
| CN109669037A (en) | A kind of Seperated multiple channel chromatographic apparatus | |
| KR101661098B1 (en) | Multiwell cuvette with integrated reaction and detection means | |
| CN101120253B (en) | Immunochromatographic test instrument and semiquantitative method using the same | |
| JPH01229969A (en) | Improved immunological analysis of membrane support type | |
| AU644096B2 (en) | Blood testing device | |
| JPH01502526A (en) | Immunoassay elements complete with everything you need | |
| CN109669038B (en) | Portable multichannel chromatographic device | |
| TW201215365A (en) | Fecal occult blood testing device | |
| US4832916A (en) | Chromatographic column for immunological determining methods | |
| US4268268A (en) | Method and apparatus for characterization of cells, particles, and liquids | |
| CN209542626U (en) | A kind of Seperated multiple channel chromatographic apparatus | |
| JP3233795U (en) | Sample collection and detection device | |
| CN111323575A (en) | Structure of test strip for detecting various products | |
| CN110160819A (en) | Fecal specimens are collected and extraction element | |
| CN112595854B (en) | Automatic change nanometer enzyme immunoassay appearance | |
| CN209656714U (en) | A kind of push type multichannel chromatographic apparatus | |
| CN209656713U (en) | A kind of portable multi-channel chromatographic apparatus | |
| CN209264735U (en) | A kind of high pass amount detecting device for two-step method immunochromatography | |
| CN109669036A (en) | A kind of push type multichannel chromatographic apparatus | |
| CN204177806U (en) | A kind of immunity-chromatography test strip | |
| US20140011190A1 (en) | Method for performing a rapid test | |
| CN109212185B (en) | One-step fast detection kit for pepsinogen I |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |