CN209311176U - Automatic analyzer sample extraction pre-processing device - Google Patents

Abstract

The utility model discloses a kind of automatic analyzer sample extraction pre-processing device, including sample tray automatic feed mechanism, sample tray can be accommodated and automatic loading moves back sample；Centrifuge can load centrifuge tube and adjust the angle of centrifuge tube and rotation axis；Glass slide dyeing tank is fed output mechanism, can convey the dyeing component being assembled by glass slide, canister and substrate；First pipetting device, for the liquid in the sample tray in sample bottle to be transferred in the centrifuge tube in the centrifuge；Second pipetting device, for the liquid in centrifuge tube to be transferred in the dyeing component；And it is matched in the centrifuge tube transfer device and filtering network management transfer device of centrifuge, it is matched in the first pipette tips replacement mechanism of the first pipetting device, is matched in the second pipette tips replacement mechanism of the second pipetting device.The utility model can be realized the full-automatic operation of sample extraction pre-treatment, greatly reduce manual operation amount, improve the degree of standardized work.

Description

Automatic analyzer sample extraction pre-processing device

Technical field

The utility model relates to automatic checkout equipment technical fields, more particularly, to a kind of automatic analyzer sample extraction Pre-processing device.

Background technique

Appearances of automatic diagosis machine substantially increases the accuracy for testing and analyzing result, still, still use at present manually into The pre-treatments work such as row sample collection extraction.According to statistics, sample extraction pre-treatment occupies about entire 60% or more analytic process Time, complex steps take time and effort；Secondly as lack standardization and standardization, about 50% analytical error from Sample extraction pre-treatment link.Further, since should have personnel's intervention in the process, there are contaminated risks for sample.

Summary of the invention

The utility model provides a kind of automatic analyzer sample extraction pre-processing device, be integrated with automatic sampling, from The functions such as the heart, concussion, it is therefore intended that solution available sample acquisition extraction pre-treatment work is time-consuming and laborious, is easy to cause analysis result There is the problem of error.

To achieve the above object, the utility model can take following technical proposals:

Automatic analyzer described in the utility model sample extraction pre-processing device, including

Sample tray automatic feed mechanism can accommodate sample tray and carry out the automatic loading of sample tray and move back automatically Sample；

Centrifuge can load centrifuge tube and adjust the angle of centrifuge tube and rotation axis；

Glass slide dyeing tank is fed output mechanism, can convey the dyeing group being assembled by glass slide, canister and substrate Part；

First pipetting device, for by the liquid in the sample tray in sample bottle be transferred in the centrifuge from In heart pipe；

Second pipetting device, for the liquid in the centrifuge tube to be transferred in the dyeing component；

And it is matched in the centrifuge tube transfer device and filtering network management transfer device of the centrifuge, it is matched in described first First pipette tips of pipetting device replace mechanism, are matched in the second pipette tips replacement mechanism of second pipetting device.

Vortex vibrator and matched mechanism for filling liquid are additionally provided on the framework soleplate.

The sample tray automatic feed mechanism includes sample presentation guide rail disposed in parallel and moves back sample guide rail, the sample presentation guide rail Upper sliding is provided with the sample presentation push rod of cylinder driving, it is described move back on sample guide rail that sliding is provided with cylinder driving move back sample push rod；It send Sample guide rail and the endless-belt being vertically installed with below analyzer sample needle between sample guide rail is moved back, the endless-belt side It is arranged in parallel with propelling track, sliding is provided with the pallet fixture block of endless-belt driving on the propelling track；On bottom plate It is additionally provided with the pallet shake table being located on pallet sample presentation channel.

The centrifuge includes support frame, and outer sleeve is provided on support frame as described above top plate, passes through axis in the outer sleeve It holds and is connected with motor-driven inner sleeve, rotation axis is equipped in the inner sleeve, is socketed with compressed spring in the rotation axis, It is provided with mutually matched spline on the joint surface of rotation axis and inner sleeve, is correspondingly arranged on and support frame bottom below rotation axis The connected lifting cylinder of plate；It is connected with rotating cage at the top of inner sleeve, multiple through-holes are uniformly provided on the side wall of the rotating cage, it is described Via top is hinged with test tube and puts card, and the test tube is put and is provided with the rotating arm extended into through-hole on card；Rotation axis top Portion is provided with lifting disk, and the lifting disk periphery is provided with multiple connected articulated jibs corresponding with the rotating arm.

First pipetting device includes multi-dimensional movement mechanism, and translation electricity is provided in the multi-dimensional movement mechanism Machine, lifting motor, rotating electric machine driving vertical connecting column, be provided with molten cutter and liquid-transfering gun on the vertical connecting column；Institute Stating molten cutter is the electric iron that end has tubular cutting head, the inclined bottom surface setting of the tubular cutting head；The liquid-transfering gun Including the suction cylinder being connected with vertical connecting column, it is socketed in the suction cylinder by pushing motor-driven piston rod, with pumping The dust collecter end that suction tube is connected is arranged with rubber holding block, and the rubber holding block is the back taper that top tape has limit baffle Shape structure.

First pipette tips replacement mechanism includes spiral round tremble pipette tips loader and pipette tips blanking device, the spiral round tremble rifle Head loader includes pipette tips storage box, and spiral helicine single pipette tips tapping channel, the single rifle are provided in the pipette tips storage box The tangentially connected single output channel of line style for having bottom to have vibrator in head tapping channel exit, the single output of line style are logical Road exit is provided with pipette tips support fixture block, and the pipette tips support fixture block, which is driven by the cylinder, to be gone up and down and be slidably connected at vertical gripper shoe On, the vertical gripper shoe is driven by the cylinder and moves along the direction perpendicular with the single output channel of line style, and vertical support The liquid-transfering gun mounting head fixing chuck plate that is provided on plate above pipette tips support fixture block and for blocking the single output channel of line style The baffle of outlet.

Automatic analyzer provided by the utility model sample extraction pre-processing device, structure is simple, easy to use, can Continuous loading melt to sample bottle cap and the operation such as cuts, realizes sample auto-pumping, transfer, centrifugation, before reaching sample extraction The full-automatic operation of processing, greatly reduces manual operation amount, improves the degree of standardized work, reduces personnel's intervention The probability polluted provides strong guarantee to the realization of sample automatical analysis.

Detailed description of the invention

Fig. 1 is the structural schematic diagram of the utility model.

Fig. 2 .1 is the structural schematic diagram of sample tray automatic feed mechanism in Fig. 1.

Fig. 2 .2 is the top view of Fig. 2 .1.

Fig. 2 .3 is the structural schematic diagram for the feeding mechanism being connected on the first material-storing box in Fig. 2 .1.

Fig. 2 .4 is the structural schematic diagram of the second material-storing box part in Fig. 2 .1.

Fig. 2 .5.1,2.5.2 are the positive and negative structural representations with the matching used sample tray of pallet fixture block in Fig. 2 .1 Figure.

Fig. 3 .1 is the structural schematic diagram of the first pipetting device in Fig. 1.

Fig. 3 .2 is the structural schematic diagram that cutter is melted in Fig. 3 .1.

Fig. 4 .1 is the structural schematic diagram of the pipette tips erector of the first pipette tips replacement mechanism in Fig. 1.

Fig. 4 .2 is the structural schematic diagram of vertical gripper shoe part in Fig. 4 .1.

Fig. 5 .1 is the structural schematic diagram of centrifuge in Fig. 1.

Fig. 5 .2 is the schematic diagram of the section structure of Fig. 5 .1 transfer shaft part.

Fig. 5 .3 is the connection structure signal that rotating cage in Fig. 5 .1 (no upper cover), lifting disk and test tube put the components such as card Figure.

Fig. 6 is the structural schematic diagram of the centrifuge tube gripping manipulator of centrifuge tube transfer device in Fig. 1.

Fig. 7 is the workflow block diagram that the utility model carries out cervical cancer cell sample extraction.

Specific embodiment

Automatic analyzer described in the utility model sample extraction pre-processing device, including sample tray can be accommodated simultaneously Carry out the automatic loading of sample tray and move back the sample tray automatic feed mechanism of sample automatically, can load centrifuge tube and adjust from The centrifuge of heart pipe and rotation axis angle can convey the load glass for the dyeing component being assembled by glass slide, canister and substrate Piece dyeing pot is fed output mechanism, for the liquid in sample tray in sample bottle to be transferred in the centrifuge tube in centrifuge First pipetting device, for by the liquid in centrifuge tube be transferred to dyeing component in the second pipetting device, and be matched in from The centrifuge tube transfer device and filtering network management transfer device of scheming are matched in the first pipette tips replacement mechanism of the first pipetting device, It is matched in the second pipette tips replacement mechanism of the second pipetting device, further includes that can carry out vortex concussion to sample further Vortex vibrator, the above mechanism, which is used in combination, to be sampled the sample to be analysed being placed in sample bottle with realization, is centrifuged, shaking The full-automatic operation for extracting pre-treatment such as swing.

Illustrate above-mentioned sample extraction pre-processing device below by way of specific embodiment.

As shown in Figure 1, sample tray automatic feed mechanism 1 is provided on bottom plate M, sample tray automatic feed mechanism 1 Sampling side is provided with the first pipetting device 2, centrifuge 3 and vortex vibrator 4, and 4 side of vortex vibrator is provided with the second liquid relief Mechanism 5 and glass slide dyeing tank are fed output mechanism 6.Cross-infection occurs between sample in order to prevent, guarantees a same pipe, the Mating mating second pipette tips that are provided with of 7 second pipetting device of the first pipette tips replacement mechanism 5 that are provided with of one pipetting device 2 replace mechanism 8, centrifuge 3 is mating to be provided with centrifuge tube transfer device 9 and filtering network management transfer device 10, and vortex vibrator 4 is configured with fluid injection Mechanism 11.

Specifically, as shown in Fig. 2 .1,2.2, sample tray automatic feed mechanism 1 includes being arranged in parallel in sending on bottom plate M Sample guide rail 1.1 and move back sample guide rail 1.2, sliding is provided with the sample presentation push rod 1.3 of cylinder driving on sample presentation guide rail 1.1, moves back sample guide rail On 1.2 sliding be provided with cylinder driving move back sample push rod 1.4；It sample presentation guide rail 1.1 and moves back and is provided with phase therewith between sample guide rail 1.2 Vertical endless-belt 1.5,1.5 side of endless-belt are arranged in parallel with propelling track 1.6, slide setting on propelling track 1.6 There is the pallet fixture block 1.7 driven by endless-belt 1.5, two positioning pins are arranged at intervals on the top surface of pallet fixture block 1.7 1.7.1, positioning pin 1.7.1 and sample tray 1.9(are shown in Fig. 2 .5.1) the locating slot 1.9.1(of bottom is shown in Fig. 2 .5.2) match It closes.It is provided with three rows four on above-mentioned sample tray 1.9 and arranges inserting position, locating slot 1.9.1 includes two located lateral slots and one Longitudinal register slot, for the setting of longitudinal register slot in pallet center, located lateral sets slot position on the left of longitudinal register slot.Above-mentioned annular skin The working region of analyzer sample needle is respectively positioned on 1.5, propelling track 1.6 and pallet fixture block 1.7.It is provided with and is located on bottom plate M Pallet shake table 1.8 on pallet sample presentation channel, when the sample tray 1.9 being placed on it is vibrated, sample therein can It is oscillated mixing.

In order to reduce manual operation, achieve the purpose that batch processing, being provided on the pallet sample presentation channel of bottom plate M has First material-storing box 1.10.1 of automatic feeding function, moving back to be provided on sample channel in the pallet of bottom plate M has the function of automatic material receiving The second material-storing box 1.11.2.Specifically, as shown in Fig. 2 .3, the first material-storing box 1.10.1 is erected at pallet shake table 1.8 weeks It encloses, is made of vertical plates on both sides and backboard, gap setting between backboard bottom and bottom plate M, sliding is provided with cylinder drive on backboard The bottom dynamic lifting support 1.10.2, lifting support 1.10.2 is provided with a pair of and perpendicular folding clamping limb of backboard 1.10.3, which is driven by cylinder and passes through backboard and be arranged above pallet shake table 1.8；Flange splint After one sample tray 1.9 of gripping arm 1.10.3 holding, 1.9 bottom surface of sample tray and 1.8 upper surface of pallet shake table are at a distance of one The height of a sample bottle.As shown in Fig. 2 .4, the pallet of bottom plate M moves back the jacking supporting plate that cylinder driving is provided on sample channel 1.11.1, the jacking side supporting plate 1.11.1 is provided with the second material-storing box 1.11.2 of vertical plates on both sides and backboard composition, the second storing A pair of wedge-shaped supporting plate 1.11.3, wedge-shaped supporting plate 1.11.3 for being used for support sample tray 1.9 is hinged on the inner wall of box 1.11.2 Bottom bevel be slidably matched with jacking supporting plate 1.11.1, and be equipped with torsional spring on the articulated shaft of wedge-shaped supporting plate 1.11.3 1.11.4.In addition, the first material-storing box 1.10.1 and the second material-storing box 1.11.2 can also use other can be with self-feeding, rewinding Structure.

In use, multiple stackings of sample tray 1.9 for being loaded with sample bottle are placed in the first material-storing box 1.10.1, by The sample tray 1.9 of clamping limb 1.10.3 holding bottommost is opened and closed, and is shaken by the folding of folding clamping limb 1.10.3 to pallet Dynamic platform 1.8 continues feeding and carries out mixing concussion；Later, sample tray 1.9 moves to pushing guidance under the action of sample presentation push rod 1.3 It is connected at rail 1.6 and with the engaging of pallet fixture block 1.7, specifically, two positioning pins 8.1 of pallet fixture block 1.7 are respectively engaged with sample The located lateral slot 1.9.1 of the junction in length and breadth of the locating slot 1.9.1 of product pallet 1.9, sample tray 1.9 is located at left side, pallet Fixture block 1.7 then moves right；Then, cutter and liquid-transfering gun and alternately operating are melted, one by one to the sample bottle on sample tray 1.9 Bottle cap cut hole and sample suction are carried out, even if molten cutter and liquid-transfering gun first move longitudinally, first to the sample bottle of right side first row Cut hole, suction are carried out, later, pallet fixture block 1.7 drives sample tray 1.9 to move right, then to the sample bottle of right side secondary series Cut hole, suction are carried out, then, cut hole, suction are carried out to the sample bottle of third column, the 4th column, until whole samples suction finishes； Hereafter, sample tray 1.9, which is pushed to, moves back near sample guide rail 1.2, and is pushed on jacking supporting plate 1.11.1 by moving back sample push rod 1.4, Later, jacking supporting plate 1.11.1 lifts sample tray 1.9 upwards, under the pushing effect of sample tray 1.9, wedge-shaped supporting plate 1.11.3 it is flipped up, after sample tray 1.9 crosses wedge-shaped supporting plate 1.11.3, wedge-shaped supporting plate 1.11.3 is acted in torsional spring 1.11.4 Lower homing, jacking supporting plate 1.11.1 is fallen after rise, and sample tray 1.9 is lifted by wedge-shaped supporting plate 1.11.3.When the second material-storing box When filling waste sample pallet 1.9 in 1.11.2, by manually taking centralized processing away.

As shown in Fig. 3 .1,3.2, the first pipetting device 2 includes the multi-dimensional movement machine with translation, lifting and rotation function Structure and coupled molten cutter and liquid-transfering gun.Specifically, above-mentioned multi-dimensional movement mechanism is mounted on the bracket on bottom plate M, It includes the vertical plate 2.1.1 being connected with bracket, is slidably fitted with mobile framework 2.1.2 on vertical plate 2.1.1 in the horizontal direction, mobile Frame 2.1.2 is connected with the translation motor 2.1.3 ball-screw driven, and lifting electricity is equipped on the top plate of mobile framework 2.1.2 Lifter plate 2.1.5, lifter plate 2.1.5 and lifting motor 2.1.4 driving are slidably fitted in machine 2.1.4, mobile framework 2.1.2 Ball-screw is connected, and rotating electric machine 2.1.6 is equipped on lifter plate 2.1.5, rotating electric machine 2.1.6 is by synchronous belt mechanism and erects Straight connecting column 2.1.7 is connected, and vertical connecting column 2.1.7 passes through mobile framework 2.1.2 and extends downwardly.Therefore, the vertical connecting column 2.1.7 translation, lifting and rotation function may be implemented.

The vertical side connecting column 2.1.7 is connected with molten cutter, which is the electricity that end has tubular cutting head 2.2.1 Soldering iron, the inclined bottom surface setting of tubular cutting head 2.2.1, forms the scarf that angle with horizontal plane is 30-60 °.Further Ground is equipped in tubular cutting head 2.2.1 and pushes column 2.2.2 made of non-thermally conductive material, and the pushing column 2.2.2 and tubular are cut The bottom of head 2.2.1 is coplanar with, i.e. the bottom surface of pushing column 2.2.2 is identical as the bottom surface gradient of tubular cutting head 2.2.1.

The vertical other side connecting column 2.1.7 is connected with suction cylinder 2.3.1, piston rod 2.3.2 and dust collecter 2.3.3 composition Liquid-transfering gun.Specifically, pilot sleeve 2.3.4 is installed on vertical connecting column 2.1.7, pushing is installed in pilot sleeve 2.3.4 The ball-screw of motor 2.3.5 driving, the feed screw nut of ball-screw is connected with push strut 2.3.6, pilot sleeve 2.3.4 outside from Top to bottm is equipped with plug-in card plate 2.3.7, upper clip 2.3.8 and lower clip 2.3.9, the plug-in card plate 2.3.7, upper clip 2.3.8 It is connected with lower clip 2.3.9 with suction cylinder 2.3.1, piston rod 2.3.2 is connected by push plate 2.3.10 with push strut 2.3.6. The end dust collecter 2.3.3 is arranged with the rubber holding block 2.3.11 for connecting liquid-transfering gun pipette tips, rubber holding block 2.3.11 There is the inverted cone-shaped structure of limit baffle for top tape.Above-mentioned upper clip 2.3.8 is identical with the structure of lower clip 2.3.9, includes With the pilot sleeve 2.3.4 left jamming claw being hinged and connected and right jamming claw, and left and right claw by return spring be connected, so as to The liquid-transfering gun of clamping different model (referring to that suction cylinder outer diameter is different).

Under normal conditions, the first pipetting device 2 need and the first pipette tips for being made of pipette tips erector and pipette tips emptier more Structure 7 of changing planes is used cooperatively.For above-mentioned pipette tips erector using common commercially available pipette tips box or other structures, pipette tips emptier includes receiving Collection box and the pipette tips snap-gauge being disposed thereon.Under the action of multi-dimensional movement mechanism, liquid-transfering gun is moved to above pipette tips erector, is taken out Suction nozzle 2.3.3 is moved downward after being directed at disposable pipette tips opening, and pipette tips is made to be socketed in the rubber holding block of dust collecter 2.3.3 On 2.3.11；Later, molten cutter and liquid-transfering gun are alternately moved to above sample bottle, first progress bottle cap is molten cuts, then carries out sample pumping It inhales, then the sample in liquid-transfering gun is injected into the centrifuge tube inserted on centrifuge 3 again；After all suction operations, Liquid-transfering gun is moved at the pipette tips snap-gauge of pipette tips emptier, and pipette tips upper surface is made to be in contact with pipette tips snap-gauge lower surface, then, It is lifted dust collecter 2.3.3, separates pipette tips with rubber holding block 2.3.11, after the two separation, discarded pipette tips naturally fall in lower section In collection box.So far, an automatic sampling job is completed.

Above-mentioned bottle cap is molten, and to cut through journey specific as follows: being first powered makes electric iron reach set temperature, then makes tubular cutting head 2.2.1 molten cut is carried out to sample bottle cap straight down.Since the bottom of tubular cutting head 2.2.1 is scarf, lean on Under one end first be in contact with bottle cap carry out melt cut, the bottle cap other end is still connected with bottle cap body；With tubular cutting head 2.2.1 Constantly passage downwards, the cutting contour on bottle cap gradually extend, and by cut portion under the action of pushing column 2.2.2 to moving down It is dynamic to be separated with bottle cap body, form the suction hole passed through for liquid-transfering gun pipette tips.In order to avoid the molten root for cutting part and bottle cap master Body, which is completely separated, causes molten slice to fall in sample bottle, it is molten cut terminal when, the scarf highest point of tubular cutting head 2.2.1 It still needs to more than bottle cap.

As shown in Fig. 4 .1,4.2, the pipette tips erector that the first pipette tips of the utility model replace mechanism 7 includes being arranged in bottom plate Pipette tips storage box 7.1 on M is provided with spiral helicine single pipette tips tapping channel, single pipette tips tapping channel in pipette tips storage box 7.1 The tangentially connected single output channel of line style for having bottom to have vibrator 7.2 in exit, the single output channel exit of line style is set It is equipped with pipette tips support fixture block 7.3, pipette tips support fixture block 7.3, which is driven by the cylinder, to be gone up and down and be slidably mounted on parallel with pipette tips discharging direction Vertical gripper shoe 7.4 on, vertical gripper shoe 7.4 is then driven by the cylinder and along perpendicular (i.e. and line style with pipette tips discharging direction Single output channel is perpendicular) direction it is mobile.In order to cooperate with liquid-transfering gun, pipette tips installation function is realized, in vertical gripper shoe The liquid-transfering gun mounting head fixing chuck plate 7.5 being equipped on 7.4 above pipette tips support fixture block 7.3, meanwhile, in vertical gripper shoe 7.4 back side is equipped with the baffle 7.6 for blocking pipette tips discharging.Above-mentioned pipette tips support fixture block 7.3 and liquid-transfering gun mounting head are fixed Accommodating hole 7.7, the accommodating that two accommodating holes 7.7 are coaxially disposed, and are located on pipette tips support fixture block 7.3 are offered on snap-gauge 7.5 Hole 7.7 is provided with hatch frame in the side opposite with the single output channel of line style.

In use, starting shock device 7.2, causes 7.1 back plate vibration of pipette tips storage box, to make to be located in pipette tips storage box 7.1 The spiral helicine single pipette tips tapping channel in pipette tips side rotation edge be displaced outwardly, until passing through the line style of the top of vibrator 7.2 Single output channel reaches at pipette tips support fixture block 7.3, at this point, the pipette tips to be installed for being located at front end are connected to pipette tips support fixture block In 7.3 accommodating hole 7.7, vertical gripper shoe 7.4 travels forward under the cylinder drive, and baffle 7.6 is got lodged in single with Forward Pipette tips tapping channel exit prevents subsequent pipette tips from discharging, and pipette tips to be installed are then as vertical gripper shoe 7.4 reaches liquid relief The lower section of rifle, when the dust collecter of liquid-transfering gun is connected on liquid-transfering gun mounting head fixing chuck plate 7.5, cylinder drives pipette tips support fixture block 7.3 move up, and are installed on pipette tips to be installed on the dust collecter of liquid-transfering gun, complete the automatic installation of pipette tips.

Above-mentioned second pipetting device 5 is similar with the first pipetting device 2, and other than being not provided with molten cutter, remaining is homogeneous Together, it may be implemented to carry out liquid transfer between non-covered container (centrifuge tube and dyeing component).It is matched in the second pipetting device 5 Second pipette tips replacement mechanism 8 is equally made of pipette tips erector and pipette tips emptier, compared with the first pipette tips replace mechanism 7, two The pipette tips emptier structure of person is identical, and the pipette tips erector of the second pipette tips replacement mechanism 8 then uses commercially available disc pipette tips box, leads to The pushing of liquid-transfering gun dust collecter is crossed, directly pipette tips are connected on the rubber holding block of dust collecter；Pipette tips emptier and the first pipette tips The pipette tips emptier structure for replacing mechanism 7 is identical.

As shown in Fig. 5 .1,5.2,5.3, centrifuge 3 includes being mounted on bottom plate M support frame 3.1 below, and support frame 3.1 pushes up It is provided with outer sleeve 3.2 on plate, passes through upper and lower two bearings 3.3 in outer sleeve 3.2 and is connected with inner sleeve 3.5, the inner sleeve 3.5 It is connected by synchronous belt drive mechanism with motor 3.4；It is equipped with rotation axis 3.6 in inner sleeve 3.5, is equipped in rotation axis 3.6 Compressed spring 3.7, and 3.7 both ends of compressed spring are respectively arranged with the upper limit position block on inner sleeve 3.5 and are located at rotation axis Lower position block on 3.6,3.6 lower section of rotation axis and inner sleeve are additionally provided with mutually matched spline 3.8 on 3.5 joint surface, 3.6 lower section of rotation axis is then correspondingly arranged on the lifting cylinder 3.9 being mounted on 3.1 bottom plate of support frame.In motor 3.4 and lifting air Under the action of cylinder 3.9, lifting rotation function is may be implemented in rotation axis 3.6；Meanwhile when the piston rod of lifting cylinder 3.9 retracts, Compressed spring 3.7 can make the rotation axis 3.6 after rising be back to original position rapidly under the action of upper and lower limited block.

As shown in Fig. 5 .2,5.3, it is connected with rotating cage 3.10 at the top of inner sleeve 3.5, is uniformly opened up on the side wall of rotating cage 3.10 There are multiple through-holes 3.11, horizontal connection arm is installed at the top of through-hole 3.11, annular test tube is hinged on the horizontal connection arm and is put Card 3.12, test tube put 3.12 ends of card and connect the rotating arm 3.13 extended in oriented through-hole 3.11.The rotating arm 3.13 and examination It is 30-45 ° that pipe, which puts 3.12 central axis angles of card,；Lifting disk 3.14 is connected at the top of rotation axis 3.6,3.14 periphery of lifting disk is set It is equipped with multiple connected articulated jibs 3.15 corresponding with rotating arm 3.13.When rotation axis 3.6 rises, rotating arm 3.13 and articulated jib The link mechanism of 3.15 compositions makes test tube storing card 3.12 gradually tend to horizontal positioned position (see figure 2), and it is vertical to be conducive to liquid-transfering gun Sample introduction；For rotation axis 3.6 during decline, test tube puts the upper surface of card 3.12 from vertical direction gradually into lifting disk 3.14 The rotation of heart direction is adapted the revolving speed for being placed on centrifugal force and lifting disk 3.14 that interior centrifuge tube is subject to.In order to adapt to from The change in displacement of heart pipe, the middle part of above-mentioned rotating cage 3.10 are necking tubular structure, are opened up on the upper lid installed at the top of rotating cage 3.10 There is long hole corresponding with the position that test tube puts card 3.12.Centrifuge 3 is nearby additionally provided with water injecting mechanism, infuses to centrifuge Water balance guarantees that centrifuge works normally.

It is put in card 3.12 in use, centrifuge tube is inserted into test tube, then passes through the upward pushing tow of 3.9 piston rod of lifting cylinder Rotation axis 3.6, the rising of lifting disk 3.14 make articulated jib 3.15 and rotating arm 3.13 link, so that centrifuge tube be made to be in vertical Sample introduction position；After sample introduction, lifting cylinder 3.9 is deflated, and piston cylinder is detached from 3.6 bottom of rotation axis, meanwhile, motor 3.4 starts, band Turn moving axis 3.6 rotate, rotation axis 3.6 3.7 restoring force of compressed spring effect under move downward, make be centrifuged tube opening gradually to Center of rotation inclination is simultaneously adapted with centrifugal force.

The centrifuge tube inserted in centrifuge 3 is provided by disposed proximally centrifuge tube transfer device 9.Above-mentioned centrifuge tube transfer Mechanism 9 includes centrifuge tube the storage box and centrifuge tube gripping manipulator, which opens up discharge port, is horizontally arranged Centrifuge tube slide discharging under the effect of gravity；Centrifuge tube gripping manipulator (see figure 6) includes a pair of of clamping jaw 9.1, the clamping jaw 9.1 It is driven by gripper cylinder 9.2, and is connected with the rotary cylinder 9.3 that the vertical connecting column end of multi-dimensional movement mechanism is arranged in, it is above-mentioned Multi-dimensional movement mechanism can drive vertical connecting column translation, lifting and rotation, the multi-dimensional movement machine of structure and the first pipetting device 2 Structure structure is identical.

In order to be filtered to the liquid sample in injection centrifuge tube, filter screen pipe is fitted in centrifuge tube, the filtering Network management is commercial product, and filter screen is equipped on bottom angled face, and therefore, centrifuge 3 is nearby additionally provided with filtering network management and turns Telephone-moving structure 10.Above-mentioned filtering network management transfer device 10 includes filtering network management the storage box and filter screen pipe gripping manipulator, the filtering Network management the storage box is similar with the first pipette tips replacement pipette tips feeding machanism of pipette tips erector of mechanism 7, including the single feed of arc Track and the line style single feeding orbit tangentially connected with the single feeding orbit of arc, the single feeding orbit exit setting of line style There is baffle, the single feeding orbit bottom of line style is provided with vibrator, discharges by vibration, for filter screen pipe gripping manipulator Clamping.Filter screen pipe gripping manipulator includes setting in bottom plate M multi-dimensional movement mechanism below, and vertical connecting column is to bottom plate M It extends above, the clamping jaw of gripper cylinder driving is provided at the top of it.

Vortex vibrator 4 is arranged between centrifuge 3 and the second pipetting device 5, and the setting of 5 other side of the second pipetting device carries Coplin tank is fed output mechanism 6.

Vortex vibrator 4 is mounted on bottom plate M using commercial product, and mechanism for filling liquid 11 is arranged in its vicinity, for Injection medicament in sample.

Glass slide dyeing tank feed output mechanism 6 includes that the assembly of dyeing component and dyeing component convey two parts, when assembly, It slides fit into substrate, canister is placed on glass slide and is screwed with substrate connect, three is made to constitute dyeing component；Dye When colour cell part is transported to the second 5 lower section of pipetting device, receive sample extracting solution simultaneously stored, in case it is subsequent to glass slide into Row dyeing.

As shown in fig. 7, illustrating the workflow of the utility model by taking cervical cancer cell sample extraction as an example.It is specific as follows: Sample to be tested is placed in sample bottle and is placed in sample tray 1.9, is carried out certainly by sample tray automatic feed mechanism 1 It is dynamic for sample, the first pipetting device 2 to sample bottle cap carry out it is molten cut, extract later sample and by sample be transferred in centrifuge 3 into Row centrifuge separation after the supernatant liquor (waste liquid) after separation is taken away by the liquid-transfering gun of the first pipetting device 2, then passes through centrifuge tube turn Sample pellet object of the centrifuge tube gripping manipulator of telephone-moving structure 9 by centrifuge tube together with bottom is transferred in vortex vibrator 4, fluid injection Proper amount of medication is added into centrifuge tube for mechanism 11, is uniformly mixed through shaking with sample pellet object, later by the second pipetting device 5 from It extracts and transfers them in the dyeing component of glass slide dyeing tank feed output mechanism 6, prepare for dyeing in next step.

The liquid-transfering gun of above-mentioned first pipetting device 2 installs new pipette tips a before carrying out imbibition, is extracting centrate It is replaced after (supernatant liquor)；Second pipetting device 5 is then carrying out sample (centrifugation and pharmaceutical mixture) suction The replacement of pipette tips b is carried out after transfer；Before the first pipetting device 2 carries out fluid injection, centrifuge tube transfer device 9 is into centrifuge 3 Centrifuge tube is installed, filtering network management transfer device 10 installs filtering network management, after centrifuge tube fluid injection is completed, filter screen into centrifuge tube Pipe transfer device 10 will filter network management and remove, and be centrifuged later；Sample (centrifugation and medicament mixing in centrifuge tube Object) be extracted move into glass slide dyeing tank feed output mechanism 6 in after, by centrifuge tube transfer device 9 by centrifuge tube together in pipe Residue is removed from vortex vibrator 4 together.Above-mentioned discarded pipette tips a, discarded pipette tips b and discarded centrifuge tube after collection into Row centralized processing.

In addition, reasonable Arrangement centrifuge, vortex can be required to shake according to sample survey when carrying out the detection of other sample analysis The quantity of dynamic device, pipetting device etc. and position, specifically design sample extraction process flow.

Claims (6)

1. a kind of automatic analyzer sample extraction pre-processing device, it is characterised in that: including

Sample tray automatic feed mechanism can accommodate sample tray and carry out the automatic loading of sample tray and move back sample automatically；

Centrifuge can load centrifuge tube and adjust the angle of centrifuge tube and rotation axis；

Glass slide dyeing tank is fed output mechanism, can convey the dyeing component being assembled by glass slide, canister and substrate；

First pipetting device, the centrifuge tube for being transferred to the liquid in the sample tray in sample bottle in the centrifuge It is interior；

Second pipetting device, for the liquid in the centrifuge tube to be transferred in the dyeing component；

And it is matched in the centrifuge tube transfer device and filtering network management transfer device of the centrifuge, it is matched in first liquid relief First pipette tips of mechanism replace mechanism, are matched in the second pipette tips replacement mechanism of second pipetting device.

2. automatic analyzer according to claim 1 sample extraction pre-processing device, it is characterised in that: on framework soleplate It is additionally provided with vortex vibrator and matched mechanism for filling liquid.

3. automatic analyzer according to claim 1 or 2 sample extraction pre-processing device, it is characterised in that: the sample Product pallet automatic feed mechanism includes sample presentation guide rail disposed in parallel and moves back sample guide rail, and sliding is provided with gas on the sample presentation guide rail The sample presentation push rod of cylinder driving, it is described move back on sample guide rail that sliding is provided with cylinder driving move back sample push rod；It sample presentation guide rail and moves back sample and leads The endless-belt being vertically installed with below analyzer sample needle between rail, the endless-belt side are arranged in parallel with propulsion Guide rail, sliding is provided with the pallet fixture block of endless-belt driving on the propelling track；It is additionally provided on bottom plate and is located at support Pallet shake table on disk sample presentation channel.

4. automatic analyzer according to claim 1 or 2 sample extraction pre-processing device, it is characterised in that: it is described from Scheming includes support frame, and outer sleeve is provided on support frame as described above top plate, motor is connected with by bearing in the outer sleeve and drives Dynamic inner sleeve is equipped with rotation axis in the inner sleeve, compressed spring, rotation axis and inner sleeve is socketed in the rotation axis Joint surface on be provided with mutually matched spline, be correspondingly arranged on the lifting air being connected with support frame bottom plate below rotation axis Cylinder；It is connected with rotating cage at the top of inner sleeve, multiple through-holes are uniformly provided on the side wall of the rotating cage, the via top is hinged with Test tube puts card, and the test tube is put and is provided with the rotating arm extended into through-hole on card；It is provided with lifting disk at the top of rotation axis, The lifting disk periphery is provided with multiple connected articulated jibs corresponding with the rotating arm.

5. automatic analyzer according to claim 1 or 2 sample extraction pre-processing device, it is characterised in that: described One pipetting device includes multi-dimensional movement mechanism, is provided with translation motor, lifting motor, rotation in the multi-dimensional movement mechanism Motor-driven vertical connecting column is provided with molten cutter and liquid-transfering gun on the vertical connecting column；The molten cutter is end band There are the electric iron of tubular cutting head, the inclined bottom surface setting of the tubular cutting head；The liquid-transfering gun includes and vertical connecting column Connected suction cylinder is socketed in the suction cylinder by pushing motor-driven piston rod, the suction being connected with suction cylinder Head end is arranged with rubber holding block, and the rubber holding block is the inverted cone-shaped structure that top tape has limit baffle.

6. automatic analyzer according to claim 1 or 2 sample extraction pre-processing device, it is characterised in that: described It includes spiral round tremble pipette tips loader and pipette tips blanking device that one pipette tips, which replace mechanism, and the spiral round tremble pipette tips loader includes rifle Head storage box is provided with spiral helicine single pipette tips tapping channel, the single pipette tips tapping channel outlet in the pipette tips storage box Locate the tangentially connected single output channel of line style for thering is bottom to have vibrator, the single output channel exit of line style is provided with Pipette tips support fixture block, the pipette tips support fixture block, which is driven by the cylinder, to be gone up and down and is slidably connected in vertical gripper shoe, the vertical support Plate is driven by the cylinder and moves along the direction perpendicular with the single output channel of line style, and is provided in vertical gripper shoe positioned at rifle Liquid-transfering gun mounting head fixing chuck plate above head rest fixture block and the baffle for blocking the single output channel outlet of line style.