CN209304724U - Whole br ain slices mold - Google Patents
Whole br ain slices mold Download PDFInfo
- Publication number
- CN209304724U CN209304724U CN201821963014.3U CN201821963014U CN209304724U CN 209304724 U CN209304724 U CN 209304724U CN 201821963014 U CN201821963014 U CN 201821963014U CN 209304724 U CN209304724 U CN 209304724U
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- CN
- China
- Prior art keywords
- mold
- recessed portion
- major diameter
- brain sample
- cutting die
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Abstract
The utility model provides a kind of brain sample wafer cutting die, including mold and mold base, and mold is equipped with recessed portion and a plurality of longitudinal grooving that is equidistantly separated by distribution of the upper surface from mold to lower recess；Recessed portion has major diameter and minor axis, major diameter corresponds to the major diameter of the sagittal plane of brain sample, minor axis corresponds to the major diameter of the coronal-plane of brain sample, and recessed portion further includes two depressions for being respectively provided at major diameter both ends, and the depression is outside from recessed portion and extends upwardly to the upper surface of mold；The longitudinal direction grooving extends along the coronal-plane of mold from the upper surface of mold vertically downward, and depth exceeds the minimum point of recessed portion；The label of a transverse direction is equipped at the middle part of recessed portion depth on the wall outer surface of mold, the label extends beyond all longitudinal groovings and the mold base carrying mould body and is equipped with graduated scale.
Description
Technical field
The utility model relates to a kind of whole br ain slices molds for non-human primate.
Background technique
In nervous system zoopery, researcher need to the whole cerebral perfusion sample of acquirement according to Coronal into
Row substantially cut, thus further gross specimen is cut into the brain piece of some tens of pm for brain morphosis, physiology and
The research such as pathology.
It is only useful for the brain section mold of rodent (for example, rat and mouse) both at home and abroad at present.These molds
General configuration be one and rat or the slightly approximate recessed portion of Mouse Whole Brain outside of belly shape are processed on a metal block, and from
The upper surface of metal block is cut into a plurality of equidistant, depth vertically downward, longitudinally or transversely and is slightly less than recessed portion lowest part
Cutter guide groove.
However since the brain sample of larger animal especially non-human primate is larger, manually substantially cut often
The phenomenon that often having positional shift leads to not the operation for carrying out next step.It is long because the big brain volume of non-human primate is big
Axis is longer, when carrying out privileged site slice, needs to be cut apart from brain front end specific range.However existing meninx is cut
Piece model does not have corresponding scale, therefore operator often has certain deviation.Simultaneously in cutting process, researcher needs
The position of front and rear combined line (an important anatomic landmarks line) is observed, and existing rodent meninx is without corresponding mark
Note.So even existing rodent mold is amplified, non-human primate brain sections can not be suited very well
Demand.
Although there is rodent brain wafer cutting die currently on the market, there is no non-human primate whole br ain slices still
Mold.Therefore, it is necessary to specially design a kind of whole br ain slices mold dedicated for non-human primate.
Utility model content
To overcome the shortcomings of existing mold, the characteristics of for large-scale experiment animal (for example, non-human primate) and reality
The requirement of border sectioning, the utility model devise a kind of whole br ain slices mold dedicated for large-scale experiment animal.
The brain sample wafer cutting die of the utility model includes mold and mold base, and mold is equipped with one from upper table
Recessed portion and a plurality of longitudinal grooving for being equidistantly separated by distribution towards lower recess, wherein the shape of the recessed portion and the full brain
The shape of sample is coincide, and the recessed portion has major diameter and minor axis, and the major diameter corresponds to the sagittal plane of the brain sample
Major diameter (that is, the maximum distance of antinion to occipital pole), the minor axis correspond to the major diameter of the coronal-plane of the brain sample (that is, two
Maximum distance between a temporo pole).The recessed portion further includes two depressions for being respectively provided at major diameter both ends, and the depression is from recessed
Concave portion outward and extends upwardly to the upper surface of the mold, be respectively used to accommodate forehead and the occipitalia anatomical structure of brain with
And occipitalia cerebellum.The longitudinal direction grooving extends along the coronal-plane of the mold from the upper surface of the mold vertically downward,
And depth exceeds the minimum point of the recessed portion.One is equipped at the middle part of recessed portion depth on the wall outer surface of mold
Lateral label, which corresponds to the front and rear combined line of brain, and the label extends beyond all longitudinal groovings, Yi Jisuo
It states mold base and carries the mold, and the mold base is equipped with graduated scale.
In a preferred embodiment, the label can be strip-shaped groove, be also possible to mark line (that is, label
Lines).In the case where being mark line, various suitable technical bids as known in the art can be passed through in process
Note on mold, for example, laser-induced thermal etching, dyestuff coating etc., can also temporarily be used according to the concrete condition of sample marker pen into
Line flag.In the case where being strip-shaped groove, can be processed using proper technology as known in the art.
In the present invention, the shape of mold is unrestricted, and it is various to can be cuboid, square, spheroid etc.
Shape or cross section are the cylinder of rectangle, square, ellipse etc., as long as can be mounted on mold base and wherein
Recessed portion can be set to carry brain sample.
In the present invention, the size and shape of recessed portion can be according to the size and shape of the brain of the animal of slice
Shape is designed, for example, the major diameter of recessed portion can take the range of 4-10cm, and minor axis is the range of 3-9cm, deep for monkey brain
Degree is the range of 3-9cm.The depth of longitudinal grooving should can generally exceed recessed portion at least more than the depth of recessed portion as a result,
Depth 1-3cm.In the present invention, the higher metal of hardness or plastics can be used in the rapidoprint of mold and mold base
Material selects unrestricted as long as being suitable for slice.
In one embodiment, mold base and mold can be integrated.In another embodiment, mold base
It can be with mold and detachably to install.
In the present invention, the outermost that the zero point of graduated scale can correspond to the either end of longitudinal grooving is longitudinally cut
Slot preferably corresponds to outermost longitudinal grooving of the one end for placing antinion.In specific measurement, referring to anatomical atlas, measure
Distance of the object construction apart from zero point, is cut in corresponding position, can be more accurate, more efficient.
The utility model has the beneficial effects that
Since front and rear combined line is the specific anatomic marker line of inhuman primate brain, the anatomy mark is utilized
Will line can instruct the direction of brain section, and therefore, the utility model can contribute to more quasi- using the combination of graduated scale and label
Really, brain sections are faster carried out, the Efficiency and accuracy of cutting is greatly improved.Using markings to indicate front and rear combined company
Line adds graduated scale on mold, unnecessary cutting can be avoided to lead with the position of more accurate quick positioning object construction
The brain tissue impairment of cause.
Detailed description of the invention
Fig. 1 is the schematic perspective view of an embodiment of the brain sample wafer cutting die of the utility model.
Fig. 2 is the side sectional view of the brain sample wafer cutting die of Fig. 1.
Fig. 3 is the front view of the brain sample wafer cutting die of Fig. 1.
Fig. 4 is the top view of the brain sample wafer cutting die of Fig. 1.
Specific embodiment
The preferred embodiment of the utility model is described with reference to the accompanying drawing, it will be understood by those skilled in the art that be following
The embodiment in conjunction with described in attached drawing or embodiment are merely to illustrate the preferred forms for realizing the utility model, rather than incite somebody to action this
The range of utility model is limited to these embodiments.The utility model can make various change on the basis of following embodiments
Into and variation.Such modifications and variations are included within the scope of the utility model.In the shown in the drawings of the utility model
Between each embodiment, similar reference numerals indicate similar component.
Definition
Distal side or distal end: in the present specification, when description the utility model refers to " distal side or distal end ", the term or class
As Terminology refer to far from user or the close side from syringe needle.
Nearside or proximal end: in the present specification, when description the utility model refers to " nearside or proximal end ", the term or class
As Terminology refer to close to user or far from syringe needle side.
Sagittal plane: flat by the plane (i.e. median sagittal plane) of animal body (or other objects) vertical axis and the longitudinal axis and with it
Capable all planes are referred to as sagittal plane, i.e., animal body or object are divided into left and right two halves.
Coronal-plane: all by the plane and all planes in parallel of animal body (or other objects) vertical axis and horizontal axis
Animal body or object are divided into former and later two parts by referred to as coronal-plane, i.e. these planes.In the present invention, before mentioning object
Face and below when, both with respect to for the coronal-plane of animal body or object.
Diameter: the definition of diameter is arrived by a planar graph or solid (such as circle, conic section, ball, cube) center
The distance of point-to-point transmission on side.Herein, diameter refers to the maximum length of object.Object with irregular shape is come
It says, diameter is the length of the longest cross section of the object.
Fig. 1 is the schematic perspective view of an embodiment of the brain sample wafer cutting die of the utility model.Such as Fig. 1
Shown, brain sample wafer cutting die 1 includes mold 2 and mold base 3, and mold 3 is equipped with recessed portion 8 and a plurality of is equidistantly separated by
Longitudinal grooving 4 of distribution.Recessed portion 8 coincide from upper surface to lower recess, shape and the shape of brain sample, big for placing
Brain sample.The pole A (antinion corresponding to brain sample) and the pole B that can also be seen that recessed portion 8 from Fig. 1 (correspond to brain sample
Occipital pole) be respectively equipped with two depressions 7, two depressions extend outwardly respectively from recessed portion 8, and extend upwardly to mold 2
Upper surface.The depression 7 of the pole A can be used for accommodating the forehead of brain, and the depression 7 of the pole B can be used for accommodating occipitalia and cerebellum.Mould
Have 3 carrying mould body 2 of seat, and is equipped with graduated scale 6.
Fig. 2 is the side sectional view of the brain sample wafer cutting die 1 of Fig. 1.It can be seen in fig. 2 that longitudinal grooving 4 is along mold
2 coronal-plane extends vertically downward from the upper surface of mold 2, and depth exceeds the minimum point of recessed portion 8 (dotted portion).?
On the wall outer surface of mold 2 the middle part of 8 depth of recessed portion (that is, substantially at half, in actual use can be according to reality
The brain sample of animal is tested to mark at any time) it is equipped with the label 5 of a transverse direction, which extends beyond all longitudinal groovings 4,
Front and rear combined line corresponding to brain sample.Although in the embodiment of fig. 2, display label 5 is the form of mark line,
It is to be understood that label 5 can take any form, if can auxiliary operation person clearly identify front and rear combined line,
Such as, but not limited to, strip-shaped groove.
In the present invention, although showing that mold 2 is the cylinder that section is ellipse, shape in Fig. 1 and Fig. 2
It is unrestricted, it can be the various shapes such as cuboid, square, spheroid or cross section be rectangle, square and circle
Deng cylinder, as long as can be mounted on mold base 3 and recessed portion 8 wherein can be set.
Fig. 3 is the front view of the brain sample wafer cutting die of Fig. 1.Although showing that mold base 3 and mold 2 are one in Fig. 3
Body, it will be recognized to those skilled in the art that the two was also possible to detachably to install.
Fig. 4 is the top view of the brain sample wafer cutting die 1 of Fig. 1.It is shown in Fig. 4, the zero point of graduated scale 6 corresponds to the pole A
The outermost longitudinal direction grooving 4 of (i.e. the antinion of brain sample) side.Certainly, zero point also can be set in the other end, i.e. occipital pole one
End.In specific measurement, it is referred to anatomical atlas, distance of the object construction apart from zero point is measured, is cut in corresponding position
It cuts.
The utility model can be used according to the following steps: operator according to label and graduated scale, determines slice portion first
Position simultaneously determines first grooving, in first grooving that ordinary blade insertion is determined, while being inserted into two blades in adjacent
Second grooving.First histotomy can be taken out of by taking out two blades.The a piece of blade that second grooving leaves is used for
Guarantee that tissue block structure and position are stablized.Continue while being inserted into two blades to can be obtained second group in adjacent grooving later
Knit slice.It repeats above operation, until the slice work at required position is fully completed.
Although the specific embodiment of the utility model has had been illustrated and described, for those skilled in the art
Member for it is readily apparent that can be made in the case where not departing from the utility model in essence and range it is various other change and
Modification, these versions are included within the scope of the utility model.
Claims (5)
1. a kind of brain sample wafer cutting die, including mold and mold base, the mold is equipped with one from the mold
Recessed portion and a plurality of longitudinal grooving that is equidistantly separated by distribution of the upper surface of body to lower recess, it is characterised in that
The recessed portion has major diameter and minor axis, and the major diameter corresponds to the major diameter of the sagittal plane of the brain sample, described short
Diameter corresponds to the major diameter of the coronal-plane of the brain sample, the recessed portion further include be respectively provided at two of major diameter both ends it is recessed
Cave, the depression is outside from the recessed portion and extends upwardly to the upper surface of the mold,
The longitudinal direction grooving extends along the coronal-plane of the mold from the upper surface of the mold vertically downward, and depth is super
The minimum point of the recessed portion out,
The label of a transverse direction is equipped at the middle part of the recessed portion depth on the wall outer surface of mold, the label prolongs
All longitudinal groovings are extended over, and
The mold base carries the mold, and the mold base is equipped with graduated scale.
2. brain sample wafer cutting die described in claim 1, it is characterised in that the label is strip-shaped groove or mark line.
3. brain sample wafer cutting die described in claim 1, it is characterised in that the mold base and the mold are one
's.
4. brain sample wafer cutting die described in claim 1, it is characterised in that the mold base and the mold are removable
Unload installation.
5. brain sample wafer cutting die described in claim 1, it is characterised in that the scale zero of the graduated scale corresponds to institute
State the outermost longitudinal direction grooving of the either end of longitudinal grooving.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821963014.3U CN209304724U (en) | 2018-11-27 | 2018-11-27 | Whole br ain slices mold |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821963014.3U CN209304724U (en) | 2018-11-27 | 2018-11-27 | Whole br ain slices mold |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209304724U true CN209304724U (en) | 2019-08-27 |
Family
ID=67674564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821963014.3U Expired - Fee Related CN209304724U (en) | 2018-11-27 | 2018-11-27 | Whole br ain slices mold |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209304724U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114038290A (en) * | 2021-10-28 | 2022-02-11 | 天津医科大学临床医学院 | Agar embedded type whole brain tomography specimen manufacturing device and method |
| WO2023126546A1 (en) * | 2022-01-03 | 2023-07-06 | Universität Zürich | Container for the storage and mri analysis of brains in pathology |
-
2018
- 2018-11-27 CN CN201821963014.3U patent/CN209304724U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114038290A (en) * | 2021-10-28 | 2022-02-11 | 天津医科大学临床医学院 | Agar embedded type whole brain tomography specimen manufacturing device and method |
| WO2023126546A1 (en) * | 2022-01-03 | 2023-07-06 | Universität Zürich | Container for the storage and mri analysis of brains in pathology |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190827 Termination date: 20201127 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |