CN211704926U - Big mouse brain stereotaxic device of accurate location - Google Patents
Big mouse brain stereotaxic device of accurate location Download PDFInfo
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- CN211704926U CN211704926U CN201921918815.2U CN201921918815U CN211704926U CN 211704926 U CN211704926 U CN 211704926U CN 201921918815 U CN201921918815 U CN 201921918815U CN 211704926 U CN211704926 U CN 211704926U
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Abstract
The utility model relates to a big mouse brain three-dimensional positioning device of accurate location, including fixed establishment and three-dimensional coordinate positioning mechanism, three-dimensional coordinate positioning mechanism sets up on fixed establishment upper portion, and coordinate pole, regulation about coordinate pole, the regulation coordinate pole about three-dimensional coordinate positioning mechanism includes interconnect's regulation, installs the rotation axis at locating lever coordinated control axle bottom, and coaxial demountable installation has rotatory spacing dish on this rotation axis. The utility model has the advantages of being scientific and reasonable in design, structure convenient to use utilizes fixed establishment and three-dimensional coordinate positioning mechanism to realize the fixed of laboratory mouse to can be accurate adjust and fix three-dimensional coordinate effectively, be provided with rotatory spacing dish simultaneously, effectively solve punch and microinjection manual operation have the problem that deviation and rate of accuracy are not high, be applicable to the drill bit and the microinjector of multiple specification, effectively improve experiment accuracy and experimental efficiency.
Description
Technical Field
The utility model belongs to animal experiment field relates to brain stereotaxic device, especially a big mouse brain stereotaxic device of accurate location.
Background
The brain stereotaxic apparatus is also called a brain fixing apparatus (english name: stereotaxic apparatus), which utilizes a three-dimensional coordinate system defined by a mark or other reference point outside the skull to determine the position of some nerve structures under the cortex, so as to carry out directional stimulation, destruction, drug injection, electric potential guidance and other researches on the nerve structures under the condition of non-direct-view exposure.
The animal brain stereotaxic apparatus is important research equipment in the fields of nerve anatomy, nerve physiology, neuropharmacology, neurosurgery and the like, is used for performing directional injection, stimulation, damage, electric potential guidance and other operations on a nerve structure, and can be used for the researches of Parkinson's disease animal model establishment, epilepsy animal model establishment, intracerebral tumor model establishment, learning and memory, intracerebral nerve stem cell transplantation, cerebral ischemia and the like. In addition, in the process of constructing the animal model, different drills are selected for positioning and punching according to the size of the head of the selected animal and the hardness of the skull of the animal, and microinjectors with different specifications are selected to inject a solution required by model construction into the positioning holes.
According to the traditional brain three-dimensional positioning device, a three-dimensional positioning rod is not provided with a structure capable of locking a scale position, after a coordinate adjusting rod adjusts a coordinate, if the adjusting rod is touched carelessly, the coordinate of the adjusting rod deviates, so that inaccurate positioning is caused, and the positioning is required to be repositioned; in the traditional brain stereotaxic device, a drill bit for punching a positioning hole and a brain stereotaxic instrument are separated, the drill bit needs to be held manually for punching, the drill bit cannot be held manually for punching right above the positioning hole during punching, the hole punched by the drill bit and the positioning hole are easy to deviate from a certain angle, so that the punching is not accurate enough, and the deviation of hole positions can be caused by the stability of holding the drill bit during punching, so that the punching accuracy is influenced; in addition, when the animal model is constructed, the drill bit and the micro-injector of different models or specifications are replaced according to different model construction requirements, and when the drill bit and the injector needle head are replaced, the original drill bit or injector needs to be detached and replaced, so that the labor cost and the operation time are increased.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to overcome prior art's weak point, provide one kind can the accurate three-dimensional scale of location and effectively fix three-dimensional coordinate axle, and can realize the accurate big or small rat brain three-dimensional positioner who fixes a position of integral type that many specifications drill bit and syringe used simultaneously.
The utility model provides a its technical problem take following technical scheme to realize:
the utility model provides a three-dimensional positioner of big mouse brain of accurate location, includes fixed establishment and three-dimensional coordinate positioning mechanism, three-dimensional coordinate positioning mechanism sets up on fixed establishment upper portion, three-dimensional coordinate positioning mechanism coordinate pole about, adjust about, coordinate pole, adjust about coordinate pole including adjusting, the regulation around coordinate pole set up on the base, the regulation around coordinate pole with adjust about coordinate pole be connected, coordinate pole is connected about adjusting about coordinate pole and adjusting about, coordinate pole connection locating lever coordinated control axle about adjusting, installs the rotation axis at locating lever coordinated control axle bottom, coaxial demountable installation has rotatory spacing dish on this rotation axis, rotatory spacing dish on set up a plurality of unit slotted holes that are used for placing drill bit and syringe.
And, the regulation around coordinate pole set up in the spout of bottom plate be provided with the scale mark on the body of rod of coordinate pole around the regulation, coordinate pole about the regulation all are provided with rotatory axostylus axostyle, rotation axis pole coaxial thread revolves in the sleeve pipe that has the scale, sliding sleeve is equipped with slide caliper rule on rotation axis pole, is provided with the fixed axostylus axostyle of taking the spring in one side of slide caliper rule.
And, on the rotation shaft lever, the other side of slide caliper rule is provided with the clamp that is used for locking the rotation shaft lever.
And, fixed establishment include bottom plate, stopper and gag lever post, two the stopper symmetry set up on the bottom plate the stopper on seted up the spacing groove, two the gag lever post can dismantle the symmetry and set up at the spacing inslot that corresponds, the gag lever post through setting up the fix with screw on the stopper.
The utility model has the advantages that:
1. this device utilizes three-dimensional coordinate positioning mechanism to realize the accurate fixed of three-dimensional coordinate to realize fixed function through the clamp that sets up on rotatory axostylus axostyle, solved because table surface rocks the scale of coordinate pole and takes place skew problem easily.
2. This device installs the rotation axis at locating lever coordinated control axle bottom, coaxial demountable installation has rotatory spacing dish on this rotation axis, set up a plurality of unit slotted holes that are used for placing drill bit and syringe on this rotatory spacing dish, can place drill bit and microinjector according to actual experiment needs, it has the problem of deviation to have solved to punch and inject, it is more accurate to make to drill and microinjection, and need not artifical manual adjustment position, use manpower sparingly and time cost, effectively improve experiment validity.
3. The fixing device of the device is provided with a bottom plate, a limiting block and a limiting rod, and the head of the laboratory mouse is fixed by adjusting the limiting rod and fixing the limiting rod through screws.
4. The utility model has the advantages of being scientific and reasonable in design, structure convenient to use utilizes fixed establishment and three-dimensional coordinate positioning mechanism to realize the fixed of laboratory mouse to can be accurate adjust and fix three-dimensional coordinate effectively, be provided with rotatory spacing dish simultaneously, effectively solve punch and microinjection manual operation have the problem that deviation and rate of accuracy are not high, be applicable to the drill bit and the microinjector of multiple specification, effectively improve experiment accuracy and experimental efficiency.
Drawings
Fig. 1 is a front view of the present invention;
fig. 2 is a top view of fig. 1.
Detailed Description
The present invention will be described in further detail with reference to the following embodiments, which are illustrative, not restrictive, and the scope of the invention should not be limited thereto.
The utility model provides a big mouse brain stereotaxic device of accurate location, as shown in figure 1, includes fixed establishment and three-dimensional coordinate positioning mechanism, three-dimensional coordinate positioning mechanism sets up on fixed establishment upper portion, fixed establishment include bottom plate 11, stopper 10 and gag lever post 8, two the stopper symmetry set up on the bottom plate the stopper on seted up the spacing groove, two the gag lever post can dismantle the symmetry and set up at the spacing inslot that corresponds, the gag lever post fix through setting up screw 9 on the stopper.
Three-dimensional coordinate positioning mechanism coordinate pole 1 about including adjusting around 15, the regulation, coordinate pole 4 about the regulation, as shown in figure 2, the regulation around coordinate pole set up on the base, the regulation around coordinate pole with adjust about the coordinate pole be connected, coordinate pole about the regulation with adjust about coordinate pole be connected, coordinate pole about the regulation is connected with the regulation, coordinate pole connection locating lever coordinated control axle 5 about the regulation, at locating lever coordinated control axle bottom install rotation axis 6, coaxial demountable installation has rotatory spacing dish 7 on this rotation axis, rotatory spacing dish on set up a plurality of unit slotted holes 14 that are used for placing drill bit and syringe.
Adjust around the coordinate pole set up in the spout 16 of bottom plate be provided with the scale mark on the body of rod of coordinate pole around adjusting, coordinate pole about adjusting, adjust about the coordinate pole, coordinate pole all are provided with rotatory axostylus axostyle, rotation axis pole coaxial screw revolves soon in sleeve pipe 3 that has the scale, sliding sleeve is equipped with slide caliper rule 13 on rotation axis pole, is provided with the fixed axostylus axostyle 12 of taking the spring in one side of slide caliper rule on the rotatory axostylus axostyle, the opposite side of slide caliper rule is provided with clamp 2 that is used for locking rotatory axostylus axostyle.
The utility model discloses a theory of operation:
the utility model provides a three-dimensional positioning device of big and small mouse brains with accurate positioning, which is used for brain three-dimensional positioning operation in the process of constructing a rat or mouse brain model, in the process of brain three-dimensional positioning of a rat or a mouse, after skin of an animal brain is manually cut off, specific positioning coordinates are referred, coordinate rods before and after adjustment in a three-dimensional coordinate positioning mechanism with scales on the three-dimensional positioning device of the big and small mouse brains, coordinate rods on the left and right sides of adjustment and up and down coordinate rods of adjustment are utilized to realize the positioning of three-dimensional scales, a knob on one side of a rod of a coordinate rod is manually rotated, a spring on the coordinate rod is used for stretching and retracting and a linkage control shaft of the positioning rod, the coordinate rod is moved to a specific scale, the rotating shaft rod is locked by a clamp arranged on the rotating shaft rod, the linkage control shaft of the positioning rod is driven at the same time, a, then, a drill bit is used for punching at an positioning point, and finally a microinjector is used for injecting a specific solution required by constructing an animal model into the hole.
Although the embodiments of the present invention and the accompanying drawings are disclosed for illustrative purposes, those skilled in the art will appreciate that: various substitutions, changes and modifications are possible without departing from the spirit and scope of the present invention and the appended claims, and therefore, the scope of the present invention is not limited to the disclosure of the embodiments and the accompanying drawings.
Claims (4)
1. The utility model provides a big mouse brain stereotaxic device of accurate location which characterized in that: including fixed establishment and three-dimensional coordinate positioning mechanism, three-dimensional coordinate positioning mechanism sets up on fixed establishment upper portion, three-dimensional coordinate positioning mechanism coordinate pole about, adjust about, coordinate pole, adjust about coordinate pole including adjusting, the regulation around coordinate pole set up on the base, the regulation around coordinate pole with adjust about coordinate pole be connected, coordinate pole about with adjusting about coordinate pole is connected, coordinate pole connection locating lever coordinated control axle about adjusting, installs the rotation axis at locating lever coordinated control axle bottom, coaxial demountable installation has rotatory spacing dish on this rotation axis, rotatory spacing dish on set up a plurality of unit slotted holes that are used for placing drill bit and syringe.
2. The device for stereotactically localizing rat brain with precise localization according to claim 1, characterized in that: coordinate pole setting in the spout of bottom plate around adjusting be provided with the scale mark on the body of rod of coordinate pole around adjusting, coordinate pole about adjusting, adjust about the coordinate pole, coordinate pole all is provided with rotatory axostylus axostyle, rotation axis pole coaxial thread revolves soon in the sleeve pipe that has the scale, sliding sleeve is equipped with slide caliper rule on rotation axis pole, is provided with the fixed axostylus axostyle of taking the spring in one side of slide caliper rule.
3. The device for stereotactically localizing rat brain with precise localization according to claim 2, characterized in that: and a hoop used for locking the rotating shaft rod is arranged on the other side of the caliper on the rotating shaft rod.
4. The device for stereotactically localizing rat brain with precise localization according to claim 1, characterized in that: the fixing mechanism comprises a bottom plate, limiting blocks and limiting rods, the limiting blocks are symmetrically arranged on the bottom plate, limiting grooves are formed in the limiting blocks, the limiting rods can be detachably and symmetrically arranged in the corresponding limiting grooves, and the limiting rods are fixed through screws arranged on the limiting blocks.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921918815.2U CN211704926U (en) | 2019-11-08 | 2019-11-08 | Big mouse brain stereotaxic device of accurate location |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921918815.2U CN211704926U (en) | 2019-11-08 | 2019-11-08 | Big mouse brain stereotaxic device of accurate location |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN211704926U true CN211704926U (en) | 2020-10-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201921918815.2U Active CN211704926U (en) | 2019-11-08 | 2019-11-08 | Big mouse brain stereotaxic device of accurate location |
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| Country | Link |
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| CN (1) | CN211704926U (en) |
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2019
- 2019-11-08 CN CN201921918815.2U patent/CN211704926U/en active Active
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