CN209039470U - Sterile material storage and transfer device - Google Patents
Sterile material storage and transfer device Download PDFInfo
- Publication number
- CN209039470U CN209039470U CN201821507340.3U CN201821507340U CN209039470U CN 209039470 U CN209039470 U CN 209039470U CN 201821507340 U CN201821507340 U CN 201821507340U CN 209039470 U CN209039470 U CN 209039470U
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- appendix
- liquid
- feed pipe
- valve
- bag
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- 239000000463 material Substances 0.000 title claims abstract description 80
- 238000012546 transfer Methods 0.000 title claims abstract description 30
- 238000003860 storage Methods 0.000 title claims abstract description 28
- 239000007788 liquid Substances 0.000 claims abstract description 72
- 238000010438 heat treatment Methods 0.000 claims description 6
- 230000002572 peristaltic effect Effects 0.000 claims description 4
- 238000000034 method Methods 0.000 abstract description 15
- 239000002699 waste material Substances 0.000 abstract description 9
- 239000011344 liquid material Substances 0.000 description 20
- 239000012530 fluid Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Vacuum Packaging (AREA)
Abstract
The utility model relates to sterile material storage and transfer devices.Specifically, the utility model provides a kind of storage of sterile material and transfer device, and described device includes material bag, and material bag is equipped with feed pipe, discharge nozzle and the first appendix, and the first appendix is connected with feed pipe by the second appendix；Feed pipe is equipped with liquid flow measuring device, the first liquid valve and liquid filter；First appendix is equipped with first gas valve and air filter, and first gas valve is between material bag and the first appendix and the tie point of the second appendix, and the tie point of the first appendix and the second appendix is between first gas valve and air filter；Second appendix is equipped with second gas valve, and the tie point of the second appendix and feed pipe is between material bag and second liquid valve；Discharge nozzle is equipped with liquid flow measuring device, second liquid valve and pressure pump.Device described in the utility model can guarantee aseptic of the material in storage and transfer process, and minimum limit avoids material waste.
Description
Technical field
The utility model relates to material storage and transfer devices, more particularly to sterile material storage and transfer device.
Background technique
In biological medicine production process, usually using existing disposable technology, especially with disposable biological reaction bag
Storage and the transfer etc. of material are carried out, disposable technology can be good at the cross contamination for avoiding face different product from producing, greatly
The efficiency of production is improved greatly, it is more and more wider using field.
Disposable biological reaction bag is before use process, typically Sterile vacuum state, therefore needs before use pair
Disposable biological reaction bag is passed through gas so that disposable biological reaction bag inflation after, be added liquid material, for store or
It is transferred to next process.But for the existing disposable biological reaction bag being commonly used in storage or transfer liquid material
There is also many defects in the process, for example, how to guarantee gas when needing to be passed through disposable biological reaction bag gas before use
Body keeps germ-free condition during entering disposable biological reaction bag；When material (or solution or product) is transferred to from a system
In disposable liquid storing bag, it may be necessary to pressurize, how guarantee so that air enters sterile discharge after liquid storing bag；Material (or solution
Or product) disposable biological reaction bag is transferred in next process (such as reactor tank), how to guarantee sterile transfer etc..In addition,
Existing disposable biological reaction bag can also have residual quantity material after handling material, cause the waste of material, especially right
The medical fluid (such as biological antibody culture solution) of some important preciousnesses, the remaining material of disposable biological reaction bag often leads to huge
Waste, especially in the multiple batches of production process of big batch, this phenomenon is particularly acute.
Therefore, this field needs to develop a kind of aseptic that can guarantee material in storage and transfer process, and minimum
Limit avoids the device of material waste.
Utility model content
The purpose of this utility model is to provide a kind of storages of sterile material and transfer device, the device to guarantee
Aseptic of the material in storage and transfer process, and minimum limit avoids material waste.
The utility model in a first aspect, providing a kind of storage of sterile material and transfer device, the device include object
Material bag 1, the material bag are disposable sterilized vacuum bag, and it is defeated that the material bag is equipped with feed pipe 2, discharge nozzle 3 and first
Tracheae 4, first appendix are connected with the feed pipe by the second appendix 5；
The feed pipe is equipped with liquid flow measuring device 6, the first liquid valve 7 and liquid filter 8；
First appendix is equipped with first gas valve 9 and air filter 10, and the first gas valve is located at object
Between material bag and the tie point 11 of the first appendix and the second appendix, the connection of first appendix and the second appendix
Point 11 is between first gas valve 7 and air filter 10；
Second appendix is equipped with second gas valve 12, and the tie point 13 of second appendix and feed pipe is located at
Between material bag and the first liquid valve；
The discharge nozzle is equipped with liquid flow measuring device 14, second liquid valve 15 and pressure pump 16.
In another preferred example, the tie point 13 of second appendix and feed pipe is located at the material bag and liquid
Between body filter 8.
In another preferred example, the tie point 13 of second appendix and feed pipe is located at the material bag and liquid
Between body flow measuring unit 6.
In another preferred example, the pressure pump is peristaltic pump.
In another preferred example, the air filter is equipped with heater.
In another preferred example, the heater is heating mantle.
In another preferred example, the tie point and air mistake of the first gas valve, the first appendix and the second appendix
Filter is successively sequentially located on first appendix, and the first gas valve is near material bag.
In another preferred example, the tie point of the second appendix and feed pipe, liquid flow measuring device, liquid filter and first
Liquid valve is successively sequentially located on the feed pipe, and the tie point of second appendix and feed pipe is near object
Material bag.
In another preferred example, on the direction far from material bag, the tie point of the second appendix and feed pipe, liquid flow
Measuring device, liquid filter and the first liquid valve are successively sequentially located on the feed pipe.
In another preferred example, the discharge nozzle is equipped with liquid filter.
In another preferred example, first appendix is equipped with gas flow device 17.
It should be understood that in the scope of the utility model, above-mentioned each technical characteristic of the utility model and below (such as implementation
Example) in specifically describe each technical characteristic between can be combined with each other, to form a new or preferred technical solution.It is limited to
Length, not repeated them here.
Detailed description of the invention
Fig. 1 is sterile material storage and transfer device structural schematic diagram in a preference of the utility model.
Wherein, each number represents in attached drawing 1:
1 it is material bag, 2 be feed pipe, 3 be discharge nozzle, 4 be the first appendix, 5 be the second appendix, 6 is fluid flow
Device, 7 for the first liquid valve, 8 be liquid filter, 9 be first gas valve, 10 be air filter, 11 be the first appendix and
The tie point of second appendix, 12 be second gas valve, 13 be the tie point of the second appendix and feed pipe, 14 be fluid flow
Device, 15 be second liquid valve, 16 be pressure pump and 17 be gas flow device.
Specific embodiment
The present inventor is by extensively and in-depth study, developing a kind of storage of sterile material and transfer device.At this
The storage of sterile material described in utility model and transfer device include material bag, and the material bag is equipped with feed pipe, discharge nozzle
With the first appendix, first appendix is connected with the feed pipe by the second appendix, described in the utility model
Device can not only guarantee aseptic of the material in storage and transfer process, but also can minimum limit avoid material unrestrained
Take.On this basis, inventor completes the utility model.
Term
Unless otherwise defined, belonging to the meaning and the utility model of all technical and scientific terms used herein
The meaning that field those of ordinary skill is commonly understood by is identical.
As used herein, the terms "include", "comprise" are used interchangeably with " containing ", not only include open definition, also
Including semi-enclosed and closed definition.In other words, the term include " by ... constitute ", " substantially by ... structure
At ".
As used herein, term " on ", etc. instructions orientation or positional relationship be orientation based on the figure or position
Relationship is merely for convenience of the creation of description the utility model and simplifies description, rather than the device or member of indication or suggestion meaning
Part must have a particular orientation, be constructed and operated in a specific orientation, therefore should not be understood as to the utility model creation
It limits.
As used herein, term " first ", " second ", etc. be used for description purposes only, be not understood to indicate or imply
Relative importance or the quantity for implicitly indicating indicated technical characteristic.Defining the features such as " first ", " second " as a result, can
To explicitly or implicitly include one or more of the features.
As used herein, term " sterile material storage and transfer device " is used interchangeably with " device ".
For ease of description, further describe the utility model below in conjunction with attached drawing 1, in the utility model it should be understood that
It is that attached drawing does not limit the scope of the utility model.
Typically, the utility model provides a kind of storage of sterile material and transfer device, the device include material bag
1, the material bag is disposable sterilized vacuum bag, and the material bag is equipped with feed pipe 2, discharge nozzle 3 and the first appendix
4, first appendix is connected with the feed pipe by the second appendix 5；
The feed pipe is equipped with liquid flow measuring device 6, the first liquid valve 7 and liquid filter 8；
First appendix is equipped with first gas valve 9 and air filter 10, and the first gas valve is located at object
Between material bag and the tie point 11 of the first appendix and the second appendix, the connection of first appendix and the second appendix
Point 11 is between first gas valve 7 and air filter 10；
Second appendix is equipped with second gas valve 12, and the tie point 13 of second appendix and feed pipe is located at
Between material bag and the first liquid valve；
The discharge nozzle is equipped with liquid flow measuring device 14, second liquid valve 15 and pressure pump 16.
Sterile material storage described in the utility model and a typical basic functional principle of transfer device include:
1, before liquid material is added to disposable sterilized vacuum bag, first gas valve is opened, closes second gas valve,
First appendix is connect with gas source (such as compressed air bottle), and the gas in gas source enters one after air filter sterilizes
Secondary property Sterile vacuum bag when filling to disposable sterilized vacuum bag to wanted degree, disconnects gas source and the first appendix
Connection, gas source stopping are passed through gas；
2, then liquid material (such as biological antibody fermentation liquid) enters after the liquid filter filtering on feed pipe
Into disposable sterilized vacuum bag, the liquid filter on feed pipe ensure that liquid material enters disposable sterilized vacuum bag
Aseptic, entered in disposable sterilized vacuum bag process in liquid material, the gas of disposable sterilized vacuum bag is not open close
Cross the discharge of the first appendix.
3, after being added to liquid material, the first appendix is connect with gas source (such as compressed air bottle), closes first
Gas trap opens second gas valve, is passed through gas, the gas in gas source remains inlet tube after air filter sterilizes
Liquid material be pushed in disposable sterilized vacuum bag, so that residual liquid material in feed pipe is avoided, to avoid material
Waste, after the material in feed pipe fully enters disposable sterilized vacuum bag, close second gas valve, disconnect gas source with
The connection of first appendix.
4, it other processes is transferred to from disposable sterilized vacuum bag (is such as transferred to the anti-of next step when to liquid material needs
Answer in tank), open the second liquid valve of the first gas valve and discharge nozzle on the first appendix, cracking pressure pump, most of liquid
Body material is transferred in subsequent processing from the outflow of disposable sterilized vacuum bag (although pressure pump enables to most liquids
Material is transferred in subsequent processing from disposable sterilized vacuum bag, but still there are some liquid materials remain in it is disposable sterilized true
In empty bag and discharge nozzle, the effect for relying solely on pressure pump is can not to extract residual liquid material out), then, by gas source
It is connect with the first appendix, the gas of gas source enters disposable sterilized vacuum after the sterilizing of the air filter of the first appendix
Bag, by the way that residual liquid material on biological respinse bag and discharge nozzle is transferred to subsequent processing the effects of gas pressurized, vortex
In, to avoid the waste of liquid material.
In sterile material described in the utility model storage and the liquid that in transfer device, feed pipe and discharge nozzle are equipped with
Flow measuring unit can show the inlet amount of liquid material and the load of liquid material, therefore, pass through liquid flow measuring device and load
Comparison to verify the loss amount of liquid material whether in the range of restriction.
In sterile material described in the utility model storage and transfer device, first liquid valve and second liquid
Valve is control valve, and the opening and closing of first liquid valve and second liquid valve control object on feed pipe and discharge nozzle respectively
The flowing of feed liquid body starts and stops.
In a preference of the utility model, the pressure pump is peristaltic pump.
In another preference of the utility model, the air filter is equipped with heater.Preferably, described plus
Hot device is heating mantle.It is highly preferred that the heating mantle is Resistant heating set.The heater energy that the air filter is equipped with
Enough so that air filter (such as membrane filter) is in dry shape body, the liquid material of disposable sterilized vacuum bag can be prevented
Steam or condensed water (especially hot liquid material is added to process slowly cooling in feed pipe) damage air filtration of generation
Device (filter membrane as damaged membrane filter).
In another preferred example, the tie point and air mistake of the first gas valve, the first appendix and the second appendix
Filter is successively sequentially located at first appendix, and the first gas valve is near material bag.
In another preferred example, the tie point of the second appendix and feed pipe, liquid flow measuring device, liquid filter and first
Liquid valve is successively sequentially located on the feed pipe, and the tie point of second appendix and feed pipe is near object
Material bag.
In another preferred example, on the direction far from material bag, the tie point of the second appendix and feed pipe, liquid flow
Measuring device, liquid filter and the first liquid valve are successively sequentially located on the feed pipe.
In another preferred example, first appendix is equipped with gas flow device.
In another preferred example, the discharge nozzle is equipped with liquid filter.Discharge nozzle is equipped with liquid filter energy
Enough it is further ensured that aseptic of the liquid material in transfer process.
Main advantages of the present invention include:
Sterile material storage of the present invention and transfer device can guarantee nothing of the material in storage and transfer process
Bacterium property, and minimum limit avoids material waste.
The present invention will be further illustrated below in conjunction with specific embodiments.It should be understood that these embodiments are merely to illustrate this
Utility model rather than limitation the scope of the utility model.In the following examples, the experimental methods for specific conditions are not specified, leads to
Often according to normal conditions, or according to the normal condition proposed by manufacturer.Unless otherwise stated, otherwise percentage and number be by weight
It calculates.
Embodiment 1
Embodiment 1 provides a kind of storage of sterile material and transfer device, the device include material bag, the material
Bag is disposable sterilized vacuum bag, and the material bag is equipped with feed pipe, discharge nozzle and the first appendix, first gas transmission
Pipe is connected with the feed pipe by the second appendix；
The feed pipe is equipped with liquid flow measuring device, the first liquid valve and liquid filter；
First appendix is equipped with first gas valve and air filter, and the air filter is equipped with heating
Set, the tie point and air filter of the first gas valve, the first appendix and the second appendix are successively sequentially located at described
The first appendix on, and the first gas valve is near material bag；
Second appendix is equipped with second gas valve, the tie point of the second appendix and feed pipe, liquid flow measuring device,
Liquid filter and the first liquid valve are successively sequentially located on the feed pipe, and second appendix and feed pipe
Tie point near material bag；
The discharge nozzle is equipped with liquid flow measuring device, second liquid valve, peristaltic pump and liquid filter.
Sterile material storage described in the utility model and transfer device are run according to basic functional principle described above,
Can guarantee material storage and transfer process in aseptic, but also can minimum limit avoid material waste.
It is incorporated herein by reference in all documents that the utility model refers to, just as each document quilt
It is individually recited as with reference to such.In addition, it should also be understood that, after having read the above-mentioned teaching content of the utility model, this field skill
Art personnel can make various changes or modifications the utility model, and such equivalent forms equally fall within the application appended claims
Book limited range.
Claims (8)
1. a kind of sterile material storage and transfer device, which is characterized in that the device includes material bag (1), the object
Material bag is disposable sterilized vacuum bag, and the material bag is equipped with feed pipe (2), discharge nozzle (3) and the first appendix (4), institute
The first appendix stated is connected with the feed pipe by the second appendix (5)；
The feed pipe is equipped with liquid flow measuring device, the first liquid valve (7) and liquid filter (8)；
First appendix is equipped with first gas valve (9) and air filter (10), and the first gas valve is located at object
Between material bag and the tie point (11) of the first appendix and the second appendix, the company of first appendix and the second appendix
Contact (11) is located between first gas valve (9) and air filter (10)；
Second appendix is equipped with second gas valve (12), and the tie point (13) of second appendix and feed pipe is located at
Between material bag and the first liquid valve；
The discharge nozzle is equipped with liquid flow measuring device, second liquid valve (15) and pressure pump (16).
2. device as described in claim 1, which is characterized in that the pressure pump is peristaltic pump.
3. device as described in claim 1, which is characterized in that the air filter is equipped with heater.
4. device as claimed in claim 3, which is characterized in that the heater is heating mantle.
5. device as described in claim 1, which is characterized in that the first gas valve, the first appendix and the second appendix
Tie point and air filter be successively sequentially located on first appendix, and the first gas valve is near material
Bag.
6. device as described in claim 1, which is characterized in that the tie point of the second appendix and feed pipe, liquid flow measuring device,
Liquid filter and the first liquid valve are successively sequentially located on the feed pipe, and second appendix and feed pipe
Tie point near material bag.
7. device as described in claim 1, which is characterized in that the discharge nozzle is equipped with liquid filter.
8. device as described in claim 1, which is characterized in that first appendix is equipped with gas flow device (17).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821507340.3U CN209039470U (en) | 2018-09-14 | 2018-09-14 | Sterile material storage and transfer device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821507340.3U CN209039470U (en) | 2018-09-14 | 2018-09-14 | Sterile material storage and transfer device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209039470U true CN209039470U (en) | 2019-06-28 |
Family
ID=67033278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821507340.3U Active CN209039470U (en) | 2018-09-14 | 2018-09-14 | Sterile material storage and transfer device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209039470U (en) |
-
2018
- 2018-09-14 CN CN201821507340.3U patent/CN209039470U/en active Active
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| GR01 | Patent grant | ||
| GR01 | Patent grant |