CN218969244U

CN218969244U - Leak-proof DBBV valve group for vaccine production

Info

Publication number: CN218969244U
Application number: CN202222372970.7U
Authority: CN
Inventors: 徐红文; 戴晓云; 丁大运
Original assignee: Suzhou Seth Pharmaceutical Industry Research Institute Co ltd
Current assignee: Suzhou Seth Pharmaceutical Industry Research Institute Co ltd
Priority date: 2022-09-07
Filing date: 2022-09-07
Publication date: 2023-05-05
Anticipated expiration: 2032-09-07

Abstract

The utility model relates to a leak-proof DBBV valve group for vaccine production, which comprises a cell tank and a clean container for culturing cells; the transmission pipeline is arranged on one side of the bottom of the cell tank, three groups of pressure gauges are respectively arranged on the outer sides of the transmission pipeline, a first diaphragm valve is arranged in the transmission pipeline, and a fourth diaphragm valve is arranged at the output end of the transmission pipeline and used for conveying cells and materials in the cell tank. The beneficial effects of the utility model are as follows: the risk elimination that can realize cell or virus feed liquid transmission through components and parts cooperation such as transmission line and output pipeline on the one hand is convenient carries out unidirectional transport to cell and material in cell jar or the virus jar, and on the other hand can realize the separation through compressed gas to transmission line and output pipeline, avoids the virus of virus jar inside to get into in the cell jar and causes the pollution.

Description

Leak-proof DBBV valve group for vaccine production

Technical Field

The utility model relates to the technical field of vaccine production equipment, in particular to a leakage-proof DBBV valve group for vaccine production.

Background

The outbreak of new coronal epidemic situation exposes the short plate of our understanding to biological safety, in order to resist the harm of new coronavirus to people, need to adopt the mode of inoculation to promote people to the resistance ability of new coronavirus, when carrying out the production of vaccine, need add new coronavirus to the cell feed liquid that cultivates, traditional cell or the transmission of virus feed liquid do not accomplish completely isolated risk, traditional transmission pipeline is facing virus transmission or crossing of different clean workshops has potential virus leakage risk, and then cause the virus to propagate between virus jar body and cell jar body and clean workshops where, the biosafety of vaccine production in-process has been destroyed, traditional transmission pipeline system washs comparatively chaotic simultaneously, and can not independently wash and disinfect cell jar and virus jar.

Disclosure of Invention

In order to overcome part of the defects in the prior art, the embodiment of the utility model provides the anti-leakage DBBV valve group for vaccine production, which has the advantages of simple structure and convenience in use, can ensure the safety of a cell tank in the vaccine production and processing process, is convenient for cleaning the cell tank and a virus tank respectively, and can separate the virus tank to prevent the virus from polluting the cell tank.

The utility model relates to a leak-proof DBBV valve group for vaccine production, which comprises a cell tank and a clean container for culturing cells;

the transmission pipeline is arranged at one side of the bottom of the cell tank, three groups of pressure gauges are respectively arranged at the outer sides of the transmission pipeline, a first diaphragm valve is arranged in the transmission pipeline, and a fourth diaphragm valve is arranged at the output end of the transmission pipeline and used for transmitting cell feed liquid in the cell tank;

the output pipeline is arranged at the output end of the transmission pipeline, and the output end of the output pipeline is connected with a virus tank and is used for transmitting cell feed liquid to the virus tank and discharging dirt in the virus tank;

further, a pressure maintaining ventilation pipeline is arranged on one side of the transmission pipeline, and a second diaphragm valve is arranged in the pressure maintaining ventilation pipeline.

Further, a first discharge pipeline is arranged at a position, close to the output end, on one side of the transmission pipeline, a third diaphragm valve is arranged in the first discharge pipeline, and a second group of pressure gauges are arranged between the first discharge pipeline and the pressure maintaining ventilation pipeline.

Further, a second discharge pipeline is arranged on one side, close to the transmission pipeline, of the output pipeline, a fifth diaphragm valve is arranged in the second discharge pipeline, and a third group of pressure gauges are arranged between the output end of the output pipeline and the second discharge pipeline.

Further, the manometer adopts DYM3 diaphragm type, and the outside of manometer installation end is provided with clean TC chuck.

The utility model has the advantages that:

the risk elimination that can realize cell or virus feed liquid transmission through components and parts cooperation such as transmission line and output pipeline on the one hand is convenient carries out unidirectional transport to the feed liquid in cell jar or the virus jar, and on the other hand can realize the separation through compressed gas to transmission line and output pipeline, avoids the inside virus of virus jar probably to get into the cell jar or the cell district that its is located and causes biosafety's influence.

Can be through first exhaust line and second exhaust line cooperation for transmission pipeline and output pipeline have online cleaning and online steam sterilization function when carrying out the transmission of cell feed liquid, keep its sustainability, have increased the holistic practicality of device and biosafety when bio-pharmaceuticals.

The foregoing and other objects, features and advantages of the utility model will be apparent from the following more particular description of preferred embodiments, as illustrated in the accompanying drawings.

Drawings

In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the utility model, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

Fig. 1 is a schematic diagram of the overall structure of a DBBV valve set.

In the figure: 1. a cell tank; 2. a transmission line; 3. a pressure gauge; 4. a first diaphragm valve; 5. a pressure maintaining ventilation pipeline; 6. a second diaphragm valve; 7. a third diaphragm valve; 8. a first discharge line; 9. a fourth diaphragm valve; 10. a fifth diaphragm valve; 11. a second discharge line; 12. an output line; 13. a virus canister.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

In a preferred embodiment of the utility model, the leak-proof DBBV valve set for vaccine production comprises a cell tank 1, a clean container for culturing cells, wherein the cell tank 1 is made of stainless steel, and is subjected to electrolytic polishing treatment, so that the cell is convenient to culture by the material and surface treatment, and the cell tank is convenient to be matched with other components to produce and process vaccines;

the transmission pipeline 2 is arranged at one side of the bottom of the cell tank 1, three groups of pressure gauges 3 are respectively arranged at the outer sides of the transmission pipeline 2, a first diaphragm valve 4 is arranged in the transmission pipeline 2, a fourth diaphragm valve 9 is arranged at the output end of the transmission pipeline 2 and used for transmitting cell feed liquid in the cell tank 1, the transmission pipeline 2 is connected with the bottom of the cell tank 1 and can be used for transmitting the cell feed liquid, when the cell tank 1 is cleaned, dirt in the cell tank 1 can be independently discharged, the pressure gauges 3 are provided with three groups and can be respectively detected with the air pressure values in the transmission pipeline 2, the transmission pipeline 2 and the output pipeline 12, the first diaphragm valve 4 can be used for controlling the switch of the transmission pipeline 2, so that the transmission of the cell feed liquid can be controlled, and the fourth diaphragm valve 9 can be used for controlling the switch at the connection position of the transmission pipeline 2 and the output pipeline 12, and thus the discharged dirt can be blocked and independently cleaned and sterilized when the virus tank 13 is cleaned;

the output pipeline 12 is arranged at the output end of the transmission pipeline 2, the output end of the output pipeline 12 is connected with the virus tank 13 and is used for transmitting cell feed liquid to the virus tank 13 and discharging dirt in the virus tank 13, the output pipeline 12 can be connected with the transmission pipeline 2, so that cells can be transmitted into the virus tank 13 to produce stock solution of vaccine, and the dirt in the virus tank 13 can be discharged independently when the virus tank 13 is cleaned, and the virus tank 13 adopts the same specification as the cell tank 1 and is used for preparing virus so as to facilitate production and processing of the vaccine;

in the above embodiment, the pressure maintaining ventilation pipeline 5 is installed on one side of the transmission pipeline 2, the second diaphragm valve 6 is installed in the pressure maintaining ventilation pipeline 5, the pressure maintaining ventilation pipeline 5 can be externally connected with a pipeline, and then compressed gas is introduced into the first diaphragm valve 4 and the third diaphragm valve 7, so that the air pressure value of the pipeline between the first diaphragm valve 4 and the third diaphragm valve 7 rises, cells on the left side of the first diaphragm valve 4 and the right side of the fourth diaphragm valve 9 cannot circulate, and therefore virus cells in the virus tank 13 can be prevented from entering the transmission pipeline 2 through the output pipeline 12 and entering the cell tank 1, the cleanness of the interior of the cell tank 1 in the vaccine production process is ensured, and the second diaphragm valve 6 can control the switch of the pressure maintaining ventilation pipeline 5, and then can control the compressed gas to enter the transmission pipeline 2 for sealing protection.

In the above embodiment, the first discharge pipeline 8 is installed at a position close to the output end on one side of the transmission pipeline 2, the first discharge pipeline 8 can be used for independently discharging dirt inside the cell tank 1 when the cell tank 1 is cleaned, the third diaphragm valve 7 is installed inside the first discharge pipeline 8, the third diaphragm valve 7 can control the opening and closing of the first discharge pipeline 8, so that gas or dirt inside the transmission pipeline 2 can be discharged from the first discharge pipeline 8, the second group of pressure gauges 3 are installed between the first discharge pipeline 8 and the pressure maintaining ventilation pipeline 5, and the second group of pressure gauges 3 can be used for detecting the air pressure value of the pipeline between the first diaphragm valve 4 and the third diaphragm valve 7.

In the above embodiment, the second discharge pipeline 11 is installed on the side of the output pipeline 12 near the transmission pipeline 2, the second discharge pipeline 11 may be communicated with the output pipeline 12, so that when the fourth diaphragm valve 9 is closed, dirt inside the virus tank 13 may be guided to the second discharge pipeline 11 to be discharged, the fifth diaphragm valve 10 is installed inside the second discharge pipeline 11, the fifth diaphragm valve 10 may perform on-off control on the second discharge pipeline 11, so that fluid in the output pipeline 12 may be controlled to flow into the second discharge pipeline 11, a third group of pressure gauges 3 may be installed between the output end of the output pipeline 12 and the second discharge pipeline 11, and the third pressure gauges 3 may detect the air pressure value in the output pipeline 12.

In the above embodiment, the DYM3 diaphragm type is adopted in the pressure gauge 3, a clean TC chuck is disposed on the outer side of the installation end of the pressure gauge 3, and the pressure gauge 3 can detect the air pressure value in the pipeline, so that the tightness detection and the air pressure regulation and control of the pipeline can be realized.

Working principle: after each assembly of the device is completed, the external pipeline of the device is enabled to work, and the device is divided into four procedures in the processing process:

and (3) material transmission: closing the second diaphragm valve 6, the third diaphragm valve 7 and the fifth diaphragm valve 10, opening the rest valves, and allowing the cells in the cell tank 1 to enter the output pipeline 12 through the transmission pipeline 2 and further enter the virus tank 13;

cleaning and sterilizing the cell tank 1: after the first diaphragm valve 4 and the third diaphragm valve 7 are opened and the rest valves are closed, the dirt in the cell tank 1 enters the first discharge pipeline 8 through the transmission pipeline 2 and is discharged out of the device;

cleaning and sterilizing the virus canister 13: the fourth diaphragm valve 9 and the fifth diaphragm valve 10 are opened, and after the rest valves are closed, the dirt in the virus tank 13 enters the second discharge pipeline 11 through the output pipeline 12 so as to be discharged out of the device;

safety assurance and positive pressure protection: after the third diaphragm valve 7 and the second diaphragm valve 6 are opened and the rest valve is closed, compressed gas enters the transmission pipeline 2 between the first diaphragm valve 4 and the fourth diaphragm valve 9 through the pressure maintaining ventilation pipeline 5, is discharged through the first discharge pipeline 8, is affected by the compressed gas, and cannot be communicated with the pipeline on the left side of the first diaphragm valve 4 and the pipeline on the right side of the fourth diaphragm valve 9, so that the influence caused by mutual circulation of substances in the virus tank 13 and the cell tank 1 can be avoided, the potential risk control is further carried out on viruses in the virus tank 13, and the safety of cells in the cell tank 1 is improved.

The principles and embodiments of the present utility model have been described in detail with reference to specific examples, which are provided to facilitate understanding of the method and core ideas of the present utility model; meanwhile, as those skilled in the art will have variations in the specific embodiments and application scope in accordance with the ideas of the present utility model, the present description should not be construed as limiting the present utility model in view of the above.

Claims

1. Leak-proof DBBV valve group for vaccine production, which is characterized in that: comprises a cell tank (1), a clean container for culturing cells;

the transmission pipeline (2) is arranged at one side of the bottom of the cell tank (1), three groups of pressure gauges (3) are respectively arranged at the outer sides of the transmission pipeline (2), a first diaphragm valve (4) is arranged on the pipeline of the transmission pipeline (2), and a fourth diaphragm valve (9) is arranged at the output end of the transmission pipeline (2) and used for isolating the direction of a transmission source of the virus tank (13);

the output pipeline (12) is arranged at the output end of the transmission pipeline (2), and the virus tank (13) is arranged at the output end of the output pipeline (12).

2. The leak-proof DBBV valve set for vaccine production according to claim 1, wherein: one side of the transmission pipeline (2) is provided with a pressure maintaining ventilation pipeline (5), and a second diaphragm valve (6) is arranged in the pressure maintaining ventilation pipeline (5).

3. The leak-proof DBBV valve set for vaccine production according to claim 1, wherein: a first discharge pipeline (8) is arranged at one side of the transmission pipeline (2) close to the position of the output end, a third diaphragm valve (7) is arranged in the first discharge pipeline (8), a second group of pressure gauges (3) are arranged between the first discharge pipeline (8) and the pressure maintaining ventilation pipeline (5), and the discharge pipeline (8) is used for cleaning a cell tank and discharging dirt subjected to high-temperature sterilization.

4. The leak-proof DBBV valve set for vaccine production according to claim 1, wherein: a second discharge pipeline (11) is arranged on one side, close to the virus tank (13), of the output pipeline (12), a fifth diaphragm valve (10) is arranged in the second discharge pipeline (11), and a third group of pressure gauges (3) are arranged between the output end of the output pipeline (12) and the second discharge pipeline (11).

5. The leak-proof DBBV valve set for vaccine production according to claim 1, wherein: the pressure gauge (3) adopts DYM3 diaphragm type, and a clean TC chuck is arranged at the outer side of the installation end of the pressure gauge (3).