CN208667747U - A kind of enzymatic hydrolysis separation interlocking equipment being used to prepare drop high lithemia nano functional peptide - Google Patents
A kind of enzymatic hydrolysis separation interlocking equipment being used to prepare drop high lithemia nano functional peptide Download PDFInfo
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- CN208667747U CN208667747U CN201820729713.5U CN201820729713U CN208667747U CN 208667747 U CN208667747 U CN 208667747U CN 201820729713 U CN201820729713 U CN 201820729713U CN 208667747 U CN208667747 U CN 208667747U
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- functional peptide
- interlocking equipment
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Abstract
The utility model relates to a kind of enzymatic hydrolysis for being used to prepare drop high lithemia nano functional peptide to separate interlocking equipment, including enzymatic vessel, duplex polymeric membrane filter, duplex high speed tubular type centrifugal chiller, duplex macromolecular filtering device, purpose ceramic-film filter, filtrate tanks are already expired and do not filter liquid storage tank, enzymatic vessel, duplex polymeric membrane filter, duplex high speed tubular type centrifugal chiller, duplex macromolecular filtering device and purpose ceramic-film filter are sequentially connected in series, the filtering outlet of purpose ceramic-film filter and non-filtering outlet are separately connected and filtrate tanks are already expired, liquid storage tank is not filtered, liquid storage tank ligase solution tank is not filtered；There is circulating pump between enzymatic vessel and duplex polymeric membrane filter, high speed tubular type centrifugal chiller includes three high speed tube centrifuges in parallel.The utility model can realize that extensive, serialization production can be used for reducing the large-scale production of the functional micromolecule polypeptide of uric acid suitable for the extraction of large biological molecule, enzymatic hydrolysis and separation；It is particularly suitable for the preparation of sunflower disk active peptides.
Description
Technical field
The utility model relates to separation of biopolymer equipment technical fields more particularly to one kind to be used to prepare drop high lithemia
The enzymatic hydrolysis of nano functional peptide separates interlocking equipment.
Background technique
Phytoprotein enzymatic hydrolysis is prepared in the technique of active peptides, and influencing most significant 3 factors of Degree of Enzymatic Hydrolysis is: enzyme
Amount, enzymolysis time and hydrolysis temperature.But in industrial scale production, to realize extensive, serialization enzymatic hydrolysis and be suitable for
The separation of molecular weight product, balance are more crucial influence links with adjusting.
Utility model content
The utility model be intended to provide be used to prepare drop high lithemia nano functional peptide enzymatic hydrolysis separation interlocking equipment, it can be achieved that
On a large scale, the production of serialization.
In order to achieve the above objectives, the technical solution adopted in the utility model is as follows:
A kind of enzymatic hydrolysis separation interlocking equipment being used to prepare drop high lithemia nano functional peptide, including enzymatic vessel, duplex high score
Sub- membrane filter, duplex high speed tubular type centrifugal chiller, duplex macromolecular filtering device, purpose ceramic-film filter, be already expired filtrate tanks and
Liquid storage tank, the enzymatic vessel, duplex polymeric membrane filter, duplex high speed tubular type centrifugal chiller, duplex macromolecule mistake are not filtered
Filter and purpose ceramic-film filter are sequentially connected in series, and the filtering outlet of the purpose ceramic-film filter is connect with filtrate tanks are already expired, ceramics
The non-filtering outlet of membrane filter with do not filter liquid storage tank and connect, the liquid storage tank that do not filter is connect with enzymatic vessel；Enzymatic vessel with
Circulating pump A is equipped between duplex polymeric membrane filter.
Further, surge tank and circulating pump are equipped between duplex high speed tubular type centrifugal chiller and duplex macromolecular filtering device
B, circulating pump B are located between surge tank and duplex macromolecular filtering device.
Further, purpose ceramic-film filter is connected with high pressure recoil gas tank.
Preferably, each high speed tubular type centrifugal chiller includes three high speed tube centrifuges.
Wherein, purpose ceramic-film filter is microfiltration ceramic membrane filter.
Further, the aperture of the ceramic membrane of purpose ceramic-film filter is 100nm.
Further, the mesh number of polymeric membrane filter is 1000.
Further, the mesh number of macromolecular filtering device is 2000.
It wherein, further include extractor, the extractor connects fluid reservoir, and the fluid reservoir connects enzymatic vessel.
It further, further include nano grinder, the nano grinder is connect with extractor.
Compared with prior art, the utility model has the following beneficial effects:
The utility model can realize extensive, serialization production, suitable for the extraction of large biological molecule, enzymatic hydrolysis and divide
From can be used for reducing the large-scale production of the functional micromolecule polypeptide of uric acid.It is particularly suitable for the system of sunflower disk active peptides
It is standby.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the utility model；
In figure: 1- enzymatic vessel, 2- duplex polymeric membrane filter, 3- duplex high speed tubular type centrifugal chiller, 4- duplex high score
Sub- filter, 5- purpose ceramic-film filter, 6- are already expired filtrate tanks, 7- and do not filter liquid storage tank, 8- circulating pump A, 9- extractor, 10-
Nano grinder, 11- surge tank, 12- high pressure recoil gas tank, 13- circulating pump B, 14- fluid reservoir.
Specific embodiment
In order to make the purpose of the utility model, technical solutions and advantages more clearly understood, below in conjunction with attached drawing, to this reality
It is further elaborated with novel.
As shown in Figure 1, the enzymatic hydrolysis separation linkage disclosed by the utility model for being used to prepare drop high lithemia nano functional peptide is set
It is standby, including enzymatic vessel 1, duplex polymeric membrane filter 2, duplex high speed tubular type centrifugal chiller 3, duplex macromolecular filtering device 4, pottery
Porcelain membrane filter 5 is already expired filtrate tanks 6 and does not filter liquid storage tank 7, enzymatic vessel 1, duplex polymeric membrane filter 2, duplex high speed
Tube centrifuge group 3, duplex macromolecular filtering device 4 and purpose ceramic-film filter 5 are sequentially connected in series, and purpose ceramic-film filter 5 filters out
Mouthful with filtrate tanks 6 be already expired connect, the non-filtering outlet of purpose ceramic-film filter 5 is connect with liquid storage tank 7 is not filtered, and non-filtered fluid stores up
Tank 7 is connect with enzymatic vessel 1；Circulating pump A8 is equipped between enzymatic vessel 1 and duplex polymeric membrane filter 2.Each high speed tubular type from
Scheming group includes at least two high speed tube centrifuges being arranged in parallel, preferably, each high speed tubular type centrifugal chiller includes
Three high speed tube centrifuges.
Surge tank 11 and circulating pump B13 are equipped between duplex high speed tubular type centrifugal chiller 3 and duplex macromolecular filtering device 4,
Circulating pump B13 is located between surge tank 11 and duplex macromolecular filtering device 4.Purpose ceramic-film filter 5 is connected with high pressure recoil gas tank
12。
The mesh number of macromolecular filtering device is greater than the mesh number of duplex polymeric membrane filter.Polymeric membrane filters in the present embodiment
The mesh number of device is 1000, and the mesh number of macromolecular filtering device is 2000.Wherein, purpose ceramic-film filter 5 is microfiltration ceramic membrane filter；
Preferably, the aperture of the ceramic membrane of purpose ceramic-film filter 5 is 100nm.
In use, raw material enters extractor 9 after the crushing of nano grinder 10, extractor 9 connects fluid reservoir 14, fluid reservoir
14 connect enzymatic vessels 1, and the decomposed solution in enzymatic vessel 1 drives through circulating pump A8, first replaced with duplex polymeric membrane filter 2
Filter, using two groups it is in parallel, can the duplex high speed tubular type centrifugal chiller 3 of alternate run be filtered, filtered solution injects surge tank
11.Under the driving of circulating pump B13, the filtered fluid in surge tank 11 first passes through can alternate run, two polymeric membrane mistakes in parallel
Filter, filtered solution are separated into two parts liquid with purpose ceramic-film filter 5 again, wherein the filtered solution across ceramic membrane filter plate is
100nm or less micromolecule polypeptide mixed liquor enters and filtrate tanks 6 is already expired, spare；And be not passed through ceramic membrane filter plate is
The mixed liquor of 100nm or more polypeptide is directly entered and does not filter liquid storage tank 7, which can be slowly injected into enzymatic vessel 1, is formed
Enzymatic hydrolysis-separation circulation.So circulation, until it becomes 100nm molecular product below.It is 1.5KDa that preparative separation, which obtains molecular weight,
The active peptides of~15KDa, and the molecular weight of active peptides is concentrated mainly on 10KDa range.Concentrate is by allotment, then uses mouth
It takes liquid bottle placer and is filled into oral liquid bottle；Or solid state powder uses sealed package, for further preparing capsule, tablets and other formulations
With.
The utility model can realize extensive, serialization production, suitable for the extraction of large biological molecule, enzymatic hydrolysis and divide
From can be used for reducing the large-scale production of the functional micromolecule polypeptide of uric acid.It is particularly suitable for the system of sunflower disk active peptides
It is standby.
Certainly, the utility model can also have other numerous embodiments, without departing substantially from the spirit of the present invention and its essence
In the case where, those skilled in the art can make various corresponding changes and modifications, but these according to the utility model
Corresponding changes and modifications all should belong to the protection scope of the utility model the attached claims.
Claims (10)
1. a kind of enzymatic hydrolysis separation interlocking equipment for being used to prepare drop high lithemia nano functional peptide, it is characterised in that: including enzymatic vessel
(1), duplex polymeric membrane filter (2), duplex high speed tubular type centrifugal chiller (3), duplex macromolecular filtering device (4), ceramic membrane
Filter (5) is already expired filtrate tanks (6) and does not filter liquid storage tank (7), the enzymatic vessel (1), duplex polymeric membrane filter
(2), duplex high speed tubular type centrifugal chiller (3), duplex macromolecular filtering device (4) and purpose ceramic-film filter (5) are sequentially connected in series, described
The filtering outlet of purpose ceramic-film filter (5) is connect with filtrate tanks (6) are already expired, the non-filtering outlet of purpose ceramic-film filter (5) with
Liquid storage tank (7) connection is not filtered, and the liquid storage tank (7) that do not filter is connect with enzymatic vessel (1)；Enzymatic vessel (1) and duplex macromolecule
Circulating pump A (8) are equipped between membrane filter (2).
2. the enzymatic hydrolysis separation interlocking equipment according to claim 1 for being used to prepare drop high lithemia nano functional peptide, feature
It is: is equipped with surge tank (11) and circulating pump B between duplex high speed tubular type centrifugal chiller (3) and duplex macromolecular filtering device (4)
(13), circulating pump B (13) is located between surge tank (11) and duplex macromolecular filtering device (4).
3. the enzymatic hydrolysis separation interlocking equipment according to claim 1 or 2 for being used to prepare drop high lithemia nano functional peptide, special
Sign is: purpose ceramic-film filter (5) is connected with high pressure recoil gas tank (12).
4. the enzymatic hydrolysis separation interlocking equipment according to claim 1 for being used to prepare drop high lithemia nano functional peptide, feature
Be: each high speed tubular type centrifugal chiller includes three high speed tube centrifuges.
5. the enzymatic hydrolysis separation interlocking equipment according to claim 1 for being used to prepare drop high lithemia nano functional peptide, feature
Be: purpose ceramic-film filter (5) is microfiltration ceramic membrane filter.
6. the enzymatic hydrolysis separation interlocking equipment according to claim 5 for being used to prepare drop high lithemia nano functional peptide, feature
Be: the aperture of the ceramic membrane of purpose ceramic-film filter (5) is 100nm.
7. the enzymatic hydrolysis separation interlocking equipment according to claim 1 for being used to prepare drop high lithemia nano functional peptide, feature
Be: the mesh number of polymeric membrane filter is 1000.
8. the enzymatic hydrolysis separation interlocking equipment according to claim 1 or claim 7 for being used to prepare drop high lithemia nano functional peptide, special
Sign is: the mesh number of macromolecular filtering device is 2000.
9. the enzymatic hydrolysis separation interlocking equipment according to claim 1 for being used to prepare drop high lithemia nano functional peptide, feature
It is: further includes extractor (9), the extractor (9) connects fluid reservoir (14), and the fluid reservoir (14) connects enzymatic vessel (1).
10. the enzymatic hydrolysis separation interlocking equipment according to claim 9 for being used to prepare drop high lithemia nano functional peptide, feature
It is: further includes nano grinder (10), the nano grinder (10) connect with extractor (9).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820707957 | 2018-05-11 | ||
| CN2018207079573 | 2018-05-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208667747U true CN208667747U (en) | 2019-03-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201820729713.5U Active CN208667747U (en) | 2018-05-11 | 2018-05-16 | A kind of enzymatic hydrolysis separation interlocking equipment being used to prepare drop high lithemia nano functional peptide |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108624495A (en) * | 2018-05-11 | 2018-10-09 | 四川师范大学 | A method of preparing the sunflower disk functional activity peptide of drop high lithemia |
| CN108795748A (en) * | 2018-05-11 | 2018-11-13 | 成都市益康堂药业有限公司 | A kind of device and method for the sunflower disk functional activity peptide preparing drop high lithemia |
-
2018
- 2018-05-16 CN CN201820729713.5U patent/CN208667747U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108624495A (en) * | 2018-05-11 | 2018-10-09 | 四川师范大学 | A method of preparing the sunflower disk functional activity peptide of drop high lithemia |
| CN108795748A (en) * | 2018-05-11 | 2018-11-13 | 成都市益康堂药业有限公司 | A kind of device and method for the sunflower disk functional activity peptide preparing drop high lithemia |
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