CN210844570U - Dual plasma exchange device - Google Patents
Dual plasma exchange device Download PDFInfo
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- CN210844570U CN210844570U CN201921032795.9U CN201921032795U CN210844570U CN 210844570 U CN210844570 U CN 210844570U CN 201921032795 U CN201921032795 U CN 201921032795U CN 210844570 U CN210844570 U CN 210844570U
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- plasma
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- 230000009977 dual effect Effects 0.000 title description 6
- 239000002699 waste material Substances 0.000 claims abstract description 34
- 239000002002 slurry Substances 0.000 claims abstract description 21
- 210000004369 blood Anatomy 0.000 claims abstract description 20
- 239000008280 blood Substances 0.000 claims abstract description 20
- 210000002381 plasma Anatomy 0.000 abstract description 93
- 239000000126 substance Substances 0.000 abstract description 17
- 230000001717 pathogenic effect Effects 0.000 abstract description 16
- 238000001914 filtration Methods 0.000 abstract description 2
- 210000003462 vein Anatomy 0.000 abstract 3
- 239000012528 membrane Substances 0.000 description 20
- 102000004169 proteins and genes Human genes 0.000 description 8
- 108090000623 proteins and genes Proteins 0.000 description 8
- 239000011148 porous material Substances 0.000 description 6
- 238000000926 separation method Methods 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 102000004506 Blood Proteins Human genes 0.000 description 3
- 108010017384 Blood Proteins Proteins 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 238000002616 plasmapheresis Methods 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- 102000009027 Albumins Human genes 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 2
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- 239000003114 blood coagulation factor Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000002615 hemofiltration Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000004180 plasmocyte Anatomy 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 239000010836 blood and blood product Substances 0.000 description 1
- 229940019700 blood coagulation factors Drugs 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
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Abstract
The utility model discloses a double plasma replacement device, which comprises a blood pump, a plasma separator, a vein pot, a waste slurry pump and a waste slurry collecting bag, wherein the inlet of the blood pump is used for being connected with the arterial end of a patient, the outlet of the blood pump is connected with the inlet of the plasma separator, the first outlet of the plasma separator is connected with the inlet of the vein pot, and the outlet of the vein pot is used for being connected with the venous end of the patient; the outlet of the waste slurry pump is connected with a waste slurry bag; also comprises a plasma separating pump and a plasma component separator; the second outlet of the plasma separator is connected with the inlet of the plasma component separator through a plasma separating pump, the first outlet of the plasma component separator is connected with the inlet of the waste plasma pump, and the second outlet of the plasma component separator is connected with the inlet of the venous kettle. The double plasma exchange device of the utility model filters the plasma twice and selectively removes macromolecular pathogenic substances; meanwhile, after secondary filtration, the concentration of pathogenic substances in the blood plasma pumped by the waste plasma pump is very high, so that a large amount of pathogenic substances can be removed once.
Description
Technical Field
The utility model belongs to the technical field of medical care, in particular to dual plasma exchange device.
Background
Plasmapheresis (PE) is a blood purification therapy used to remove large molecules from blood. As shown in fig. 1, the existing plasma replacement device comprises a blood pump 1, a plasma separator 2, a venous pot 3, a waste plasma pump 4 and a waste plasma collecting bag 5, wherein an inlet of the blood pump 1 is used for being connected with an arterial end of a patient, an outlet of the blood pump 1 is connected with an inlet of the plasma separator 2, a first outlet of the plasma separator 2 is connected with an inlet of the venous pot 3, a second outlet of the plasma separator 2 is connected with the waste plasma collecting bag 5 through the waste plasma pump 4, and an outlet of the venous pot 3 is used for being connected with a venous end of the patient. The working process is as follows: the blood pump 1 is used for feeding blood into the plasma separator 2 from the arterial end of a patient, the plasma mixed with harmful substances is pumped into the waste plasma collecting bag 5 by the waste plasma pump 4 after the plasma is filtered by the plasma separator 2, and the residual plasma enters the venous pot 3 and finally returns to the venous end of a human body.
The existing plasmapheresis devices have the following disadvantages:
first, since the separation accuracy of the plasma separator 2 is low, it is impossible to selectively remove the macromolecular pathogenic factors. Thus, for therapeutic purposes, the large amount of plasma exiting the second outlet of the plasma separator 2 is eventually discarded, resulting in the loss of proteins, coagulation factors. Therefore, the replacement fluid in the replacement fluid bag 8 needs to be pumped by the replacement pump 9 to supplement the replacement fluid, and this method needs to supplement a large amount of plasma to supplement a large amount of necessary substances such as proteins and blood coagulation factors necessary for the human body, but a large amount of blood products such as plasma are often infused, which increases the risk of infection.
Second, the treatment is non-specific and does not selectively remove pathogenic agents.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a dual plasma exchange device, to above-mentioned prior art not enough, harmful substance concentration is high in the plasma that pumps through useless thick liquid pump, can get rid of pathogenic substance in a large number by the single, can also realize the selectivity simultaneously and get rid of pathogenic substance.
In order to solve the technical problem, the utility model discloses the technical scheme who adopts is:
a dual plasma replacement device comprises a blood pump, a plasma separator, a venous pot, a waste slurry pump and a waste slurry collecting bag, wherein an inlet of the blood pump is connected with an arterial end of a patient, an outlet of the blood pump is connected with an inlet of the plasma separator, a first outlet of the plasma separator is connected with an inlet of the venous pot, and an outlet of the venous pot is connected with a venous end of the patient; the outlet of the waste slurry pump is connected with a waste slurry collecting bag; it is characterized in that the plasma separator also comprises a plasma separating pump and a plasma component separator; the second outlet of the plasma separator is connected with the inlet of the plasma component separator through a plasma separating pump, the first outlet of the plasma component separator is connected with the inlet of the waste plasma pump, and the second outlet of the plasma component separator is connected with the inlet of the venous kettle.
Compared with the prior art, the utility model discloses at first adopt ordinary plasma separator (first grade membrane) to separate plasma and blood cell, adopt plasma composition separator (second grade membrane) to carry out the secondary separation to the less protein of molecular weight relatively again. After the secondary separation, the plasma containing macromolecular pathogenic substances is pumped into a waste plasma collecting bag by a waste plasma pump and is discarded, and plasma protein containing albumin and the like with relatively small molecular weight is returned to a human body.
The plasma component separator is a membrane separator for separating large molecular proteins and small molecular proteins from plasma, and the average pore size (representing the size of molecular weight cut-off) of the membrane is between that of a hemofiltration filter and that of a plasma separator. According to the different molecular weight of the pathogenic substance to be removed, the plasma component separator with different membrane pore diameters can be made for the treatment of different diseases. Taking the product of Asahi Kasei Corp., Japan, the plasma component separators are classified into four different types, EC20W, EC30W, EC40W and EC50W, from small to large according to the pore size of the membrane. The aperture of the EC20W membrane is 0.01 um, the aperture of the EC30w membrane is 0.02 um, the aperture of the EC40W membrane is 0.03 um, and the aperture of the EC50W membrane is 0.035 um. The plasma component separator can be selected according to the molecular weight of pathogenic substances to be removed in different diseases.
Therefore, the double plasma exchange device of the utility model filters the plasma twice to selectively remove the macromolecular pathogenic substances; meanwhile, after secondary filtration, the concentration of pathogenic substances in the blood plasma pumped by the waste plasma pump is very high, so that a large amount of pathogenic substances can be removed once.
Drawings
Fig. 1 is a schematic diagram of a prior art structure.
Fig. 2 is a schematic structural diagram of an embodiment of the present invention.
Wherein, 1 is a blood pump, 2 is a plasma separator, 3 is a venous kettle, 4 is a waste slurry pump, 5 is a waste slurry collecting bag, 6 is a slurry separating pump, 7 is a plasma component separator, 8 is a replacement liquid bag, and 9 is a replacement pump.
Detailed Description
As shown in fig. 1, the dual plasma replacement device comprises a blood pump 1, a plasma separator 2, a venous pot 3, a waste plasma pump 4 and a waste plasma collecting bag 5, wherein an inlet of the blood pump 1 is connected with an arterial end of a patient, an outlet of the blood pump 1 is connected with an inlet of the plasma separator 2, a first outlet of the plasma separator 2 is connected with an inlet of the venous pot 3, and an outlet of the venous pot 3 is connected with a venous end of the patient; the outlet of the waste slurry pump 4 is connected with a waste slurry collecting bag 5; also comprises a plasma separating pump 6 and a plasma component separator 7; the second outlet of the plasma separator 2 is connected with the inlet of a plasma component separator 7 through a plasma separating pump 6, the first outlet of the plasma component separator 7 is connected with the inlet of a waste slurry pump 4, and the second outlet of the plasma component separator 7 is connected with the inlet of a venous pot 3.
Compared with the prior art, the utility model discloses at first adopt ordinary plasma separator 2 (first grade membrane) to separate plasma and blood cell, adopt plasma composition separator 7 (second grade membrane) to carry out the secondary separation to the less protein of molecular weight relatively again. After the second separation, the plasma containing macromolecular pathogenic substances is pumped into a waste slurry collecting bag 5 by a waste slurry pump 4 to be discarded, and the plasma protein containing albumin and other plasma proteins with relatively small molecular weight is returned to the human body.
The plasma component separator 7 is a membrane separator for separating large molecular proteins and small molecular proteins from plasma, and has a membrane having an average pore size (size representing a molecular weight cut-off) between a hemofiltration filter and the plasma separator 2. According to the different molecular weight of the pathogenic substance, the plasma component separator 7 with different membrane pore diameters can be made for different diseases. Taking the product of Asahi Kasei Corp., Japan, the plasma component separator 7 is classified into four different types, EC20M, EC30W, EC40W and EC50W, from small to large according to the pore size of the membrane. The aperture of the EC20W membrane is 0.01 um, the aperture of the EC30w membrane is 0.02 um, the aperture of the EC40W membrane is 0.03 um, and the aperture of the EC50W membrane is 0.035 um. The plasma component separator can be selected according to the molecular weight of pathogenic substances to be removed in different diseases.
The embodiments of the present invention have been described with reference to the accompanying drawings, but the present invention is not limited to the above-mentioned embodiments, which are only illustrative and not restrictive, and those skilled in the art can make many forms without departing from the spirit and scope of the present invention, which is within the protection scope of the present invention.
Claims (1)
1. A double plasma replacement device comprises a blood pump (1), a plasma separator (2), a venous pot (3), a waste slurry pump (4) and a waste slurry collecting bag (5), wherein the inlet of the blood pump (1) is connected with the arterial end of a patient, the outlet of the blood pump (1) is connected with the inlet of the plasma separator (2), the first outlet of the plasma separator (2) is connected with the inlet of the venous pot (3), and the outlet of the venous pot (3) is connected with the venous end of the patient; the outlet of the waste slurry pump (4) is connected with a waste slurry collecting bag (5);
characterized in that the plasma separator also comprises a plasma separating pump (6) and a plasma component separator (7); the second outlet of the plasma separator (2) is connected with the inlet of the plasma component separator (7) through the plasma separating pump (6), the first outlet of the plasma component separator (7) is connected with the inlet of the waste slurry pump (4), and the second outlet of the plasma component separator (7) is connected with the inlet of the venous kettle (3).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921032795.9U CN210844570U (en) | 2019-07-04 | 2019-07-04 | Dual plasma exchange device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921032795.9U CN210844570U (en) | 2019-07-04 | 2019-07-04 | Dual plasma exchange device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210844570U true CN210844570U (en) | 2020-06-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201921032795.9U Active CN210844570U (en) | 2019-07-04 | 2019-07-04 | Dual plasma exchange device |
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| Country | Link |
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| CN (1) | CN210844570U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114225141A (en) * | 2021-10-29 | 2022-03-25 | 南京国青血液净化科技有限公司 | Adsorption filtration purification system for plasmapheresis treatment |
| CN114225140A (en) * | 2021-10-29 | 2022-03-25 | 南京国青血液净化科技有限公司 | Extracorporeal circulation system for dual plasma replacement |
-
2019
- 2019-07-04 CN CN201921032795.9U patent/CN210844570U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114225141A (en) * | 2021-10-29 | 2022-03-25 | 南京国青血液净化科技有限公司 | Adsorption filtration purification system for plasmapheresis treatment |
| CN114225140A (en) * | 2021-10-29 | 2022-03-25 | 南京国青血液净化科技有限公司 | Extracorporeal circulation system for dual plasma replacement |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210923 Address after: 510000 703, Tower B, 191 TIYU West Road, Tianhe District, Guangzhou, Guangdong Province (office only) Patentee after: Guangzhou Beishan Medical Technology Co.,Ltd. Address before: 410008 Hunan province Changsha Kaifu District, Xiangya Road No. 87 Patentee before: XIANGYA HOSPITAL OF CENTRAL SOUTH University |