CN208611358U - A kind of double-layer tablets production on line - Google Patents
A kind of double-layer tablets production on line Download PDFInfo
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- CN208611358U CN208611358U CN201720964128.9U CN201720964128U CN208611358U CN 208611358 U CN208611358 U CN 208611358U CN 201720964128 U CN201720964128 U CN 201720964128U CN 208611358 U CN208611358 U CN 208611358U
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Abstract
The utility model provides a kind of double-layer tablets production on line, comprising: the first production line, the second production line and the bi-layer tablet press being connected with the first production line and the second production line end equipment；First production line includes sequentially connected first feeder, the first granulator, granulator, drying machine, pelletizing machine and the first hopper mixing machine；Second production line includes sequentially connected second feeder, the second granulator, third granulator and the second hopper mixing machine.Two kinds of active medicines can be formed a tablet by double-layer tablets production on line provided by the utility model, by the effect for playing two kinds of active ingredients, not only it can produce good compound synergistic effect, but also avoided drug from reacting to each other during the preparation process and generate impurity, and reduced the adverse reaction to human body.
Description
Technical field
The utility model relates to medical pharmaceutical technology fields, produce on line more particularly to a kind of double-layer tablets.
Background technique
Between Non-gonococcal Cervicitis is also known as women gonococcal Urogenital Tract, Female Non-gonococcal Urethritis
(nongonococcal ure-thritis, NGU), is one kind of sexually transmitted disease.Its major part is by chlamydia trachomatis
Caused by the infection of (Ch1amydiatrachomatis, CT) and Ureaplasma urealyticum (UreaP1asmaurea1yticum, UU), wherein
Account for about 40%~50% because of CT infection, accounts for about 20%~30% caused by infecting because of UU.Patient often has cervicitis, urethritis etc.
Symptom, but can not find out gonococcus in secretion, laboratory checks neutrophilic leukocytosis in vaginal fluid or arena.Mesh
Before, chlamydia trachomatis infection is the most common cause of disease in female sex organs infectious diseases, can be drenched from 20%~40% women
Patient and 12%~29% the active women of the property being checked in isolate Chlamydia.In the U.S., estimation every about
Year is up to 250,000 chlamydial pelvic infections.Sweden has been reported that can be from 30% acute salpinitis patient and 36% uterine neck
In find Chlamydia, the recall rate of choamydiae infection also accounts for significant proportion in China's female patient, due to laboratory testing condition
It is universal, the morbidity number being detected will be in rising trend.
Clinical treatment Between Non-gonococcal Cervicitis is mainly oral antibiotic at present, but as the abuse of antibiotic is led
Causing the drug resistance of pathogenic bacteria constantly enhances, and greatly reduces therapeutic effect, causes difficulty to treatment.
Utility model content
In view of the foregoing deficiencies of prior art, the purpose of this utility model is to provide for solving the prior art
The problems in.
In order to achieve the above objects and other related objects, the utility model provides a kind of double-layer tablets production on line, comprising:
First production line, the second production line and the bi-layer tablet press being connected with the first production line and the second production line end equipment；
First production line includes sequentially connected first feeder, the first granulator, granulator, drying machine, pelletizing machine and first
Hopper mixing machine；Second production line includes sequentially connected second feeder, the second granulator, third granulator and second
Hopper mixing machine.
In one embodiment of the utility model, further includes: seed-coating machine；Wherein, the seed-coating machine is the double-deck pressure
The upstream device of piece machine, and connect by transmission part with the bi-layer tablet press.
In one embodiment of the utility model, the seed-coating machine is film coater.
In one embodiment of the utility model, first granulator is wet granulator.
In one embodiment of the utility model, the granulator is the oscillating granulator equipped with sieve.
Further, the sieve has certain mesh number.
In one embodiment of the utility model, the drying machine is boiling drier.
In one embodiment of the utility model, the pelletizing machine is equipped with sieve.
Further, the sieve has certain mesh number.
In one embodiment of the utility model, second granulator is wet granulator；The third granulator
For dry granulating machine.
In one embodiment of the utility model, first feeder and second feeder are vacuum feeding
Machine.
It further include any one of following characteristics or multinomial in one embodiment of the utility model: in the whole grain
The first lifting material transferring machine is provided between machine and the first hopper mixing machine；In the third granulator and second hopper
The second lifting material transferring machine is provided between mixing machine.
Two kinds of active medicines can be formed a tablet by double-layer tablets production on line provided by the utility model, pass through performance
The effect of two kinds of active ingredients not only can produce good compound synergistic effect, but also avoid drug mutually reciprocal during the preparation process
Impurity should be generated, the adverse reaction to human body is reduced.Double-layer tablets are easy to grasp dosage, and tablet appearance smooth and beautiful appearance, are easy to
It swallows, improves the compliance of patient's medication.
Detailed description of the invention
Fig. 1 is the structural schematic diagram that a kind of double-layer tablets provided by the utility model produce on line；
Fig. 2 is the result schematic diagram that another double-layer tablets provided by the utility model produce on line.
Component label instructions
1 first production line
11 first feeders
12 first granulators
13 granulators
14 drying machines
15 pelletizing machines
16 first hopper mixing machines
2 second production lines
21 second feeders
22 second granulators
23 third granulators
24 second hopper mixing machines
3 double-layer tablets tablet press machines
4 seed-coating machines
Specific embodiment
Before further describing specific embodiment of the present invention, it should be appreciated that the protection scope of the utility model is not
It is confined to following specific specific embodiments；It is also understood that term used in the utility model embodiment is to retouch
Specific specific embodiment is stated, rather than in order to limit the protection scope of the utility model；In the utility model specification and
In claims, unless in addition explicitly pointed out in text, singular "one", " one " and " this " include plural form.
When embodiment provides numberical range, it should be appreciated that unless the utility model is otherwise noted, the two of each numberical range
Any one numerical value can be selected between a endpoint and two endpoints.Unless otherwise defined, institute used in the utility model
There is technical and scientific term identical as the normally understood meaning of those skilled in the art of the present technique.Except specific side used in embodiment
Method, equipment, outside material, according to those skilled in the art to the grasp of the prior art and the record of the utility model, also
Any side of the prior art similar or equivalent with method described in the utility model embodiment, equipment, material can be used
Method, equipment and material realize the utility model.
Unless otherwise stated, the experimental method disclosed in the utility model, detection method, preparation method are all made of this skill
The pharmacy of art field routine, Pharmaceutical Analysis, pharmaceutical chemistry, analytical chemistry, molecular biology, biochemistry and related fields
Routine techniques.These technologies have perfect explanation in the prior art.
Clindamycin is that 6 hydroxyls of Erythromycin A are replaced and formed by methyl, belongs to a kind of novel macrolides antibiosis
Element, clindamycin can penetrate bacteria cell wall and ribosomes 50s subunit carries out irreversible combination, to block transposition work
With and transpeptidation, inhibit RNA synthesis.It has the characteristics that blood concentration is high, oral absorption is good, therefore long half time has
Higher antibacterial activity, it is especially higher to chlamydia trachomatis and Ureaplasma urealyticum sensibility, but single Clarithromycin in Treating is imitated
Fruit is unsatisfactory.Nifuratel is broad-spectrum antifungal drug, has the function of antibacterial, inhibits fungi growth and breeding, antiprotozoan, especially
It is Combination vagina infection (bacterium, reads coccus at trichomonad), and can not be with the infection for the pathogen that is difficult to clarify a diagnosis in time
In, the generation of mould suprainfection can be effectively avoided using Nifuratel.Animal experiment study confirmation, not using Nifuratel
It will lead to the variation of deformity or fertility；Chronic toxicity test is the results show that 3000 times of therapeutic doses of subcutaneous injection will not generate and appoint
What toxic reaction, securely and reliably.In recent years, clarithromycin combination Nifuratel treats Between Non-gonococcal Cervicitis, demonstrate,proved through clinic
Satisfied effect is achieved in fact.Therefore compound preparation is made in two kinds of Drug combinations of clarithromycin and Nifuratel, it can
Good synergistic effect is generated, adverse reaction is reduced, and can be convenient patient and take, enhances the drug compliance of patient.
The embodiments of the present invention provide a kind of double-layer tablets production on line, can be used for producing treatment non-gonococcal palace
The double-layer tablets of neck inflammation, the double-layer tablets are made of Nifuratel, clarithromycin.The double-layer tablets that the embodiments of the present invention provide are raw
The mentality of designing of Congress of Industrial Organizations's line is that Nifuratel and clarithromycin are pelletized respectively respectively first, then uses double-layer tablets tablet press machine pressure
Upper layer and lower layer label is made, then by the double-deck core surface film coating of compacting, label and contacting external air is isolated, to reach
To it is moisture-proof, be protected from light, anti-oxidation, enhance stability of drug products.
Fig. 1 shows the structural schematic diagram of the double-layer tablets production on line of the embodiments of the present invention offer.Such as Fig. 1 institute
It states, the double-layer tablets production on line that the embodiments of the present invention provide includes: the first production line 1, the second production line 2, Yi Jiyu
First production line 1 and the connected bi-layer tablet press 3 of 2 end-equipment of the second production line；First production line 1 includes successively connecting
The first feeder 11, the first granulator 12, granulator 13, drying machine 14, pelletizing machine 15 and the first hopper mixing machine 16 connect；Institute
Stating the second production line 2 includes that sequentially connected second feeder 21, the second granulator 22, third granulator 23 and the second hopper are mixed
Conjunction machine 24.
First production line 1 is specially the production line for handling clarithromycin.Detailed process can be with are as follows: clarithromycin starting material
Enter in the second granulator 12 through the first feeder 11, opens stirring premix 15min, adhesive is added and prepares softwood, makes
Softwood prepares particle by granulator 13；The particle made enter in drying machine it is dry, specially control temperature of charge 40~
It is 50 DEG C, dry to moisture≤3.0%；Particle after drying is transferred to pelletizing machine 15 and carries out whole grain, and the dry particl after whole grain enters the
10min, which is mixed together, with additional auxiliary material in one hopper mixing machine 16 obtains clarithromycin granule.
In one example, the first feeder 11 is vacuum feeder.
In one example, first granulator 12 is wet granulator.
In one example, the granulator 13 is the oscillating granulator with 18 mesh screens.
In one example, the drying machine 14 is boiling drier.
In one example, the pelletizing machine 15 is the pelletizing machine with 20 mesh screens.
In one example, the first promotion is additionally provided between the pelletizing machine 15 and the first hopper mixing machine 16
Material rotaring machine.Dry particl after whole grain is entered in the first hopper mixing machine 16 by the first lifting material transferring machine.
In one example, vacuum feeding pipe is provided between the granulator 13 and drying machine 14 on the first production line 1.On
It is specially that the particle made enters drying machine 14 by vacuum feeding pipe that the particle made in text, which enters drying machine 14,.
In one example, third lifting material transferring machine is provided between drying machine 14 and pelletizing machine 15, above after drying
It is specially that the particle after drying is transferred to pelletizing machine 15 by third lifting material transferring machine that particle, which is transferred to pelletizing machine 15 and carries out whole grain,.
Second production line 2 is specially the production line for handling Nifuratel.Detailed process can be Nifuratel starting material
Into in the second granulator 22, stirring premix 15min is opened；Mixed material enters in third granulator 23, specifically, can be with
Operating pressure 60bar, roller gap 1.2mm, the 1.2mm sieve whole grain of third granulator 23 are set；The dry particl made passes through
Nifuratel particle is obtained into 10min is mixed together with additional auxiliary material in the second hopper mixing machine.
In one example, the second feeder 21 is vacuum feeder.
Second granulator 22 is wet granulator in one example；The third granulator 23 is dry granulation
Machine.
In one example, second is additionally provided between the third granulator 23 and the second hopper mixing machine 24
Lifting material transferring machine.The dry particl made is entered in the second hopper mixing machine 24 by the second lifting material transferring machine.
In one example, the 4th promotion is additionally provided between second granulator 22 and the third granulator 23
Material rotaring machine.Mixed material is entered in third granulator 23 by four lifting material transferring machines in second granulator 22.
In one example, the 5th lifting material transferring machine is provided between the first hopper mixing machine 16 and bi-layer tablet press 3, the
The 6th lifting material transferring machine is provided between two hopper mixing machines 24 and bi-layer tablet press 3.The above-mentioned Nifuratel particle made with
Clarithromycin granule is put into bi-layer tablet press 3 by lifting material transferring machine, is controlled in tablet hardness about 60~80N, is obtained label.
In one example, as shown in Fig. 2, double-layer tablets provided by the utility model produce on line further include: seed-coating machine 4；
Wherein, the seed-coating machine 4 is the upstream device of the bi-layer tablet press 3, and is connected by transmission part and the bi-layer tablet press 3
It connects.
In one example, the seed-coating machine 4 is film coater.The workflow of film coater is specifically as follows,
The purified water of specified amount is added in preparing tank, starts blender, so that purified water is just formed whirlpool is advisable, and is slowly added to provide
The coating powder of amount after stirring at least 45min, reduces blender revolving speed exhaust bubble, prepares the coating solution that solid content is about 18%.It will
Double-layer tablets label is put into coating pan, opens air-heater, and label is made to preheat about 10min under low rotary drum revolving speed, opens spray gun, is adjusted
Whole 0.2~0.25MPa of atomizing pressure makes coating solution be sprayed at label upper retention tab bed tempertaure at 40 DEG C or so in spray pattern,
Seed-coating machine revolving speed should improve from slow to fast with hydrojet speed, when coating weight gain about 3.0%, continue blowing hot-air dry 10
Minute, the film-coating of uniform drying is formed, finished product is obtained.
In conclusion the utility model effectively overcomes various shortcoming in the prior art and has high industrial exploitation value
Value.
The above embodiments are only illustrative of the principle and efficacy of the utility model, and not for limitation, this is practical new
Type.Any person skilled in the art can all carry out above-described embodiment under the spirit and scope without prejudice to the utility model
Modifications and changes.Therefore, such as those of ordinary skill in the art without departing from the revealed essence of the utility model
All equivalent modifications or change completed under mind and technical idea, should be covered by the claim of the utility model.
Claims (10)
1. a kind of double-layer tablets produce on line characterized by comprising the first production line (1), the second production line (2) and with the
One production line (1) and the connected bi-layer tablet press (3) of the second production line (2) end-equipment；
First production line (1) include sequentially connected first feeder (11), the first granulator (12), granulator (13),
Drying machine (14), pelletizing machine (15) and the first hopper mixing machine (16)；
Second production line (2) includes sequentially connected second feeder (21), the second granulator (22), third granulator
(23) and the second hopper mixing machine (24).
2. double-layer tablets according to claim 1 produce on line, which is characterized in that further include: seed-coating machine (4)；Wherein, described
Seed-coating machine (4) is the upstream device of the bi-layer tablet press (3), and is connect by transmission part with the bi-layer tablet press (3).
3. double-layer tablets according to claim 2 produce on line, which is characterized in that the seed-coating machine (4) is film coater.
4. double-layer tablets according to claim 1 produce on line, which is characterized in that first granulator (12) is wet process system
Grain machine.
5. double-layer tablets according to claim 4 produce on line, which is characterized in that the granulator (13) is equipped with sieve
Oscillating granulator.
6. double-layer tablets according to claim 4 produce on line, which is characterized in that the drying machine (14) is fluidized drying
Machine.
7. double-layer tablets according to claim 6 produce on line, which is characterized in that the pelletizing machine (15) is equipped with sieve
Pelletizing machine.
8. double-layer tablets according to claim 1 produce on line, which is characterized in that second granulator (22) is wet process system
Grain machine；
The third granulator (23) is dry granulating machine.
9. double-layer tablets according to claim 1 produce on line, which is characterized in that first feeder (11) and described the
Two feeders (21) are vacuum feeder.
10. double-layer tablets according to claim 1 produce on line, which is characterized in that further include any one of following characteristics
Or it is multinomial:
The first lifting material transferring machine is provided between the pelletizing machine (15) and the first hopper mixing machine (16)；
The second lifting material transferring machine is provided between the third granulator (23) and the second hopper mixing machine (24).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720964128.9U CN208611358U (en) | 2017-08-03 | 2017-08-03 | A kind of double-layer tablets production on line |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720964128.9U CN208611358U (en) | 2017-08-03 | 2017-08-03 | A kind of double-layer tablets production on line |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208611358U true CN208611358U (en) | 2019-03-19 |
Family
ID=65688303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720964128.9U Expired - Fee Related CN208611358U (en) | 2017-08-03 | 2017-08-03 | A kind of double-layer tablets production on line |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN208611358U (en) |
-
2017
- 2017-08-03 CN CN201720964128.9U patent/CN208611358U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190717 Address after: 2/F, Building No. 5, 333 Guiping Road, Xuhui District, Shanghai, 2003 Patentee after: Shanghai Hongguan Pharmaceutical Technology Co.,Ltd. Address before: 201210 South-east Room, 8th Floor, Building 7, 500 Caobao Road, Xuhui District, Shanghai Patentee before: SHANGHAI SUNRISE MEDICAL TECHNOLOGY CO.,LTD. |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190319 Termination date: 20210803 |