CN208082371U - It is a kind of using magnetic liquid be medium it is controllable tune than microfluidic mixer device - Google Patents
It is a kind of using magnetic liquid be medium it is controllable tune than microfluidic mixer device Download PDFInfo
- Publication number
- CN208082371U CN208082371U CN201820100160.7U CN201820100160U CN208082371U CN 208082371 U CN208082371 U CN 208082371U CN 201820100160 U CN201820100160 U CN 201820100160U CN 208082371 U CN208082371 U CN 208082371U
- Authority
- CN
- China
- Prior art keywords
- coil
- tune
- cover board
- chip
- mixer device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 36
- 238000002156 mixing Methods 0.000 claims abstract description 50
- 238000000034 method Methods 0.000 claims abstract description 21
- 238000000926 separation method Methods 0.000 claims description 8
- 238000004891 communication Methods 0.000 claims description 6
- WYTGDNHDOZPMIW-RCBQFDQVSA-N alstonine Natural products C1=CC2=C3C=CC=CC3=NC2=C2N1C[C@H]1[C@H](C)OC=C(C(=O)OC)[C@H]1C2 WYTGDNHDOZPMIW-RCBQFDQVSA-N 0.000 claims description 5
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 3
- 229910052710 silicon Inorganic materials 0.000 claims description 3
- 239000010703 silicon Substances 0.000 claims description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 229910052742 iron Inorganic materials 0.000 claims 1
- 230000005389 magnetism Effects 0.000 claims 1
- 239000006249 magnetic particle Substances 0.000 abstract description 13
- 239000000126 substance Substances 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 4
- 230000009514 concussion Effects 0.000 abstract description 2
- 238000013329 compounding Methods 0.000 abstract 2
- 238000005516 engineering process Methods 0.000 description 6
- 238000005530 etching Methods 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 238000001459 lithography Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000011161 development Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 description 2
- 238000007747 plating Methods 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 230000005415 magnetization Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
Abstract
The utility model disclose it is a kind of using magnetic liquid be medium it is controllable tune than microfluidic mixer device, including chip base, chip cover board and permanent magnet；Chip cover board is fitted in chip base, and chip base and chip cover board are provided with corresponding groove, and permanent magnet is inlayed in a groove；Chip base is equipped with microchannel；Chip cover board is equipped with two groups of entrances, two tune than coil, power interface, mixing plane coil group and mixed export.The utility model promotes non-magnetic particle in magnetic liquid to generate concussion effect, completes the mixing of substance by generating proportion adjustment of the magnetic field gradient realization to compounding substances.The advantage of the utility model is that mixed process is quickly, uniformly, controllably；The physical parameters such as pH, ion, surface charge to magnetic liquid can realize bio-compatible without particular/special requirement, magnetic liquid；The proportion adjustment to compounding substances can be achieved, and can be with on-line control mixed proportion, adjusting method is efficient and convenient.
Description
Technical field
The utility model belongs to microfluidic art, and in particular to it is a kind of using magnetic liquid be medium it is controllable tune than micro-
Flow mixer.
Background technology
Since in the 1990s, A.Manz et al. proposes micro-total analysis system, micro-fluidic chip is in the whole world
It is widely studied in range.Due to micro-fluidic chip have small, light weight, price be low, easy to carry, sample consumption less,
Many advantages, such as reaction rate is fast and easy to use makes it become research hotspot in fields such as chemistry, biology, medicine.Micro-
Mechatronic Systems（MEMS）Development drive under, microflow control technique has obtained extremely fast development in recent years, all kinds of micro-fluidic
In the device course of work, two or more material mixing is key technology, therefore most occasions are not nearly all from
Open a critical function device --- microfluidic mixer device, major function are to realize that the quick of microfluid mixes with colleges and universities.
Lot of domestic and foreign researcher has been directed to microfluidic mixer device and has done a lot of work at present, and develops miscellaneous
Microfluidic mixer device.Existing microfluidic mixer device is broadly divided into active and two kinds of passive type.Active microfluidic mixer device is to borrow
External impetus, such as electricity, light, sound and temperature are mixed, and mixed process is controllable, but mixer structure is complex and to miniflow
Body physical property is more demanding；Passive type microfluidic mixer device realizes mixed process by the way that special geometry is arranged, and has knot
The simple easily fabricated advantage of structure, but mixing is more slow and mixed process is uncontrollable.Two kinds of forms are each advantageous, micro- to adapt to
The development of fluidics, in recent years people begin to take on measure and comprehensively utilize the advantage of two kinds of mixers, but be all with will be certain
For the purpose of the Microfluidic Mixing of ratio is uniform, do not have the function that adjusting ratio is realized in mixed process.
The soliquid that magnetic liquid is made of nano magnetic particle, base load liquid and surfactant three parts is
Have magnetic and mobility functional fluid concurrently.Due to the peculiar property of magnetic liquid so that magnetic liquid is in microfluidic system
In have special applications, after bio-compatibility magnetic liquid is succeeded in developing, magnetic liquid has wider application.Magnetic liquid
The manipulation of body has compared to other methods to be easily achieved, and the advantages such as is not influenced by pH, ion, surface charge, and in magnetic field
The non-magnetic particle acted in magnetic liquid can be by magnetic buoyancy, and then can be manipulated to non-magnetic particle, realizes non-
The operations such as movement, separation and the mixing of magnetic-particle.
Utility model content
The shortcomings that in order to overcome the prior art, the utility model provide one kind and good mixing effect and mixed proportion may be implemented
Controllable is that the controllable of medium is adjusted than microfluidic mixer device using magnetic liquid.
The technical solution adopted in the utility model is as follows：
A kind of using magnetic liquid is the controllable tune of medium than microfluidic mixer device, including chip base 1, chip cover board 2 and forever
Magnet 10；Chip cover board 2 is fitted in chip base 1, and chip base 1 and chip cover board 2 are provided with corresponding groove, permanent magnet
10 inlay in a groove, and magnetic pole and chip base 1 and chip cover board 2 are perpendicular；
Chip base 1 is equipped with microchannel 6；Chip cover board 2 enters equipped with the outlets A 3, A entrances 4, A tune than coil 5, B
Mouth 7, the outlets B 8, B tune are than coil 9, power interface 11, mixing plane coil group 12 and mixed export 13；
Microchannel 6 is the conduit being engraved in chip base 1, including four subchannels and a main channel；Four points logical
The one end in road is connected to main channel, and the other end is in communication with the outside by the conical through-hole being opened on chip cover board 2, respectively is
The outlets A 3, A entrances 4, B entrances 7 and the outlets B 8；Main channel one end is connected to four subchannels, and the other end runs through magnetic control mixed zone
15, it is serpentine bend at proximal end, forms geometry mixed zone 14, end is mixed by the conical through-hole being opened on chip cover board 2
Outlet 13 is closed to be in communication with the outside；It is exported in A and is equipped with A on the channel between 3 corresponding subchannels subchannel corresponding with A entrances 4
It adjusts than coil 5, is exported in 7 corresponding subchannel of B entrances and B and be equipped with B tune on the channel between 8 corresponding subchannels than coil 9,
A tune is planar coil than coil 9 than coil 5 and B tune, and A tune is than coil 5 and B tune ratios coil 9 respectively from beginning and each extraction of terminal
One conducting wire is connect with the power interface 11 for being located at 2 both sides of chip cover board, and each tune is more only by external direct current power supply respectively than coil
Vertical power supply；
The magnetic control mixed zone 15 includes the mixing plane coil group 12 and permanent magnet for being located at 6 main channel both sides of microchannel
10；Mixing plane coil group 12 is serially connected by 10 ~ 40 planar coils, is arranged symmetrically in main channel both sides, the same side
Planar coil electric current loop it is identical around direction, and with offside electric current loop around direction on the contrary, from the beginning of first coil with it is last
The terminal of one coil is respectively drawn a conducting wire and is respectively connected on the power interface for being located at 2 both sides of chip cover board, by external direct current
Power supply provides the electric current of direction mechanical periodicity；Permanent magnet 10 is two pieces, is arranged symmetrically in the both sides of mixing plane coil group 12, two
The pole orientation of block permanent magnet 10 is identical.
Preferably, chip base 1 is that transparent silicon chip is made with chip cover board 2, is bonded by the method for bonding.
Preferably, microchannel 6 is processed by the method for micro-nano technology technology lithography and etching in chip base 1,
Section is square, and the section length of side is between 20 ~ 500 μm.
Preferably, microchannel 6 is serpentine bend, a diameter of 0.5 ~ 1mm of bend, bend number at geometry mixed zone 14
Amount is 5 ~ 20.
Preferably, hub of a spool in the channel heart line on of the A tune than coil 5 and B tune than coil 9, and A tune is than in coil 5
At a distance from the heart and 4 corresponding subchannel of A entrances and main channel junction center and 9 centers of B tune ratio coils are corresponding with B entrances 7
The distance at subchannel and main channel junction center is 1 ~ 2mm.
Preferably, the vertical range at each hub of a spool and main channel center is 1 ~ 2mm in mixing plane coil group 12.
Preferably, A tune is 2 ~ 4 μm than diameter of wire in coil 9 and mixing plane coil group 12 than coil 5, B tune, conducting wire
Between distance be 2 ~ 20 μm, coil turn is between 50 ~ 200 circles；It is plated on chip cover board 2 by electric plating method.
Preferably, A tune is additionally provided with one layer of separation layer than coil 5, B tune than coil 9 and 12 surface of mixing plane coil group, prevents
Only coil or conducting wire are contacted with the magnetic liquid in channel, and the separation layer can be prepared by insulating materials such as PDMS.
Preferably, permanent magnet 10 is bar magnet, and the length of permanent magnet 10 is according to the arrangement feelings of mixing plane coil group 12
Condition determines, it should be ensured that 10 length of permanent magnet is slightly larger than the length of mixing plane coil group 12；Distance between two block permanent magnets 10 is 1
~2cm；By the method for lithography and etching respectively in the 2 corresponding position cutting of chip base 1 and chip cover board so that permanent magnet 10
Being embedded just below in slot does not influence the hermetically sealed of chip, and 10 median plane of permanent magnet and mixing plane coil group 12 are in same plane
It is interior；The intensity of magnetization of magnet can be chosen according to demand.
The course of work：The controllable tune leads to than the non-magnetic particle that the blending objects of microfluidic mixer device are in magnetic liquid
The liquid entered is to be mixed with object to be mixed（Non-magnetic particle or cell）Magnetic liquid, magnetic liquid is mutually compatible with object to be mixed
But not it reacts, does not influence subsequent reactions or operation.
Object to be mixed is mixed into magnetic liquid respectively, will be mixed with using syringe pump or miniflow pump certain density to be mixed
The magnetic liquid of object is pumped into microchannel 6 from A entrances 4 and B entrances 7 respectively；Material proportion needed for final mixed liquor with
A tune is arranged than coil 5 and B tune than the size of current of coil 9 in concentration, and adjusting can form after being powered than coil backwards to the magnetic field of main channel
Gradient, the nano magnetic particle in magnetic liquid can be non-under the action of this power by the active force in the same direction with magnetic field gradient
Magnetic-particle can be made the non-magnetic particle in magnetic liquid by the magnetic buoyancy for being directed toward main channel due to there is magnetic buoyancy
It can be biased to main channel movement, under the collective effect in flow field and magnetic field, the ratio for the non-magnetic particle for flowing to main channel can be adjusted
Example, to meet the requirements, as shown in Figure 3；A part for the magnetic liquid of the magnetic field suction generated than coil is adjusted to be exported respectively from A
3 flow at main channel and converge with 8 outflow of the outlets B, remaining magnetic liquid and non-magnetic particle therein, flow into magnetic control mixed zone
15；The DC current of direction mechanical periodicity is passed through to the mixing plane coil group 12 in magnetic control mixed zone 15, permanent magnet 10 with
Under the collective effect of mixing plane coil group 12, the magnetic field gradient for being directed toward wherein side planar coil can be formed, gradient direction by
It is passed through current direction decision, is mechanical periodicity due to being passed through current direction so that magnetic field gradient directions mechanical periodicity, so that it is non-magnetic
Property particle suffered by magnetic buoyancy direction mechanical periodicity, and then will produce concussion in the non-magnetic particle of magnetic control mixed zone flowing and make
With, promote its be uniformly mixed, such as Fig. 5（a）-5（d）It is shown, by adjusting size of current and side in mixing plane coil group 12
To the frequency of variation, the rate of mixing can be controlled；The more uniform magnetic liquid of mixing continues to flow into geometry mixed zone 14,
It mixes further the particle in magnetic liquid under the action of bend abundant, and the mixing feelings in micro- sem observation bend can be used
Condition；Uniformly mixed magnetic liquid is flowed out from mixed export 13.
In the whole process, A tune plays the role of adjusting mixture ratio than coil 9 than coil 5 and B tune, passes through tune
Each substance is different in mixing liquid ratio and concentration requirement can be realized than the size of current of coil by saving each adjust；Magnetic control mixed zone 15
The magnetic field generated using mixing plane coil group 12 and permanent magnet 10 realizes that actively mixing manipulates to mixture, mixed by adjusting
The size of current of conjunction planar coil group 12 can control to reach with frequency preferably mixes requirement；In mixed process can by
Line changes A tune than coil 5 and B tune than the electric current of coil 9, realizes the ratio and concentration of substance in On-line Control mixing liquid.
The beneficial effects of the utility model：
1, it is quick, uniform, controllable to realize material mixing in microfluid；
2, microfluid uses magnetic liquid, to fluid pH, ion, surface charge etc. without particular/special requirement, it can be achieved that raw
Object is compatible with；
3, it realizes to the proportion adjustment of substance in fluid after mixing in mixed process, and regulative mode is efficient and convenient.
Description of the drawings
FIG. 1 is a schematic structural view of the utility model；
Fig. 2 is to adjust than coil arrangement schematic diagram；
Fig. 3 is to adjust than coil working process schematic；
Fig. 4 is magnetic control mixed zone schematic diagram；
Fig. 5（a）-5（d）For magnetic control mixed zone course of work schematic diagram；
In figure：1- chip bases, 2- chip cover boards, the outlets 3-A, 4-A entrances, 5-A tune is than coil, 6- microchannels, 7-B
Entrance, the outlets 8-B, 9-B tune is than coil, 10- permanent magnets, 11- power interfaces, 12- mixing plane coil groups, 13- mixed exports,
14- geometry mixed zone, 15- magnetic controls mixed zone, fluid flow direction in the channels V-, current direction in I- coils, the magnetic fields ▽ H- ladder
Direction is spent, magnetic buoyancy direction suffered by F- mixtures.
Specific implementation mode
The utility model is described in further detail with reference to the accompanying drawings and examples, but the content of the utility model is not limited to
Shown in embodiment and attached drawing.
Embodiment 1
A kind of using magnetic liquid is the controllable tune of medium than microfluidic mixer device, including chip base 1, chip cover board 2 and forever
Magnet 10；Chip cover board 2 is fitted in chip base 1, by the method for lithography and etching in chip base 1 and chip cover board 2
It is provided with corresponding groove, permanent magnet 10 is inlayed in a groove, and magnetic pole and chip base 1 and chip cover board 2 are perpendicular；
Chip base 1 is equipped with microchannel 6, and microchannel 6 is added by the method for micro-nano technology technology lithography and etching
In chip base 1, section is square work, and the section length of side is 20 μm；Chip cover board 2 is equipped with the outlets A 3, A entrances 4, A
It adjusts than coil 5, B entrances 7, the outlets B 8, B tune than coil 9, power interface 11, mixing plane coil group 12 and mixed export 13, A
It adjusts and is all made of electric plating method than coil 9, power interface 11, mixing plane coil group 12 and connecting wire than coil 5, B tune
Processing, A tune are 2 μm than diameter of wire in coil 9 and mixing plane coil group 12 than coil 5, B tune, and separation is 2 μm,
Coil turn is 50 circles；
Microchannel 6 includes four subchannels and a main channel；One end of four subchannels is connected to main channel, another
End is in communication with the outside by the conical through-hole being opened on chip cover board 2 with chip card punch, respectively is the outlets A 3, A entrances
4, B entrances 7 and the outlets B 8；Main channel one end is connected to four subchannels, and the other end runs through magnetic control mixed zone 15, at proximal end
For serpentine bend, geometry mixed zone 14 is formed, a diameter of 1mm of bend shares 5 bends；End is by being opened in chip cover board 2
On conical through-hole mixed export 13 be in communication with the outside；Between A exports 3 corresponding subchannels subchannel corresponding with A entrances 4
Channel be equipped with A tune than coil 5, export in 7 corresponding subchannel of B entrances and B and set on the channel between 8 corresponding subchannels
There is B tune than coil 9, A tune is planar coil, more corresponding with A entrances 4 than 5 center of coil point of A tune than coil 9 than coil 5 and B tune
At a distance from channel and main channel junction center and B tune subchannel more corresponding with B entrances 7 than 9 center of coil is connect with main channel
The distance at place center is 1mm, A tune than coil 5 and B tune ratios coil 9 respectively from beginning with terminal one conducting wire of each extraction with set
Power interface 11 in 2 both sides of chip cover board connects, and each adjust separately provides direct current by external power supply respectively than coil
Stream；
The magnetic control mixed zone 15 includes the mixing plane coil group 12 and permanent magnet for being located at 6 main channel both sides of microchannel
10；Mixing plane coil group 12 is serially connected by the planar coil of 10 50 circles, is arranged symmetrically in main channel both sides, each line
Circle center and the vertical range at main channel center are 1mm, and the planar coil electric current loop of the same side is identical around direction, and electric with offside
Stream is respectively connected to set around direction on the contrary, respectively drawing a conducting wire from the terminal at the beginning of first coil and the last one coil
On the power interface of 2 both sides of chip cover board, the DC current of direction mechanical periodicity is provided by external power supply；Permanent magnet 10
Be two pieces, be bar magnet, be arranged symmetrically in the both sides of mixing plane coil group 12, and 10 median plane of permanent magnet with mix it is flat
In the same plane, the pole orientation of two block permanent magnets 10 is identical for planar coil group 12, is the poles S towards chip cover board 2, two pieces
Distance between permanent magnet 10 is 1cm.
Embodiment 2
With reference to the structure of embodiment 1, the present embodiment and the difference of embodiment 1 are, chip base 1 is equal with chip cover board 2
It is made of transparent silicon chip, is bonded by the method for bonding.
Embodiment 3
With reference to the structure of embodiment 1, the present embodiment and the difference of embodiment 1 are that 6 section of microchannel is square,
The section length of side is 500 μm.
Embodiment 4
With reference to the structure of embodiment 1, the present embodiment and the difference of embodiment 1 are that microchannel 6 is in geometry mixed zone 14
The a diameter of 0.5mm for locating bend, shares 20 bends.
Embodiment 5
With reference to the structure of embodiment 1, the present embodiment and the difference of embodiment 1 are, A tune is than coil 5 and B tune than coil 9
Hub of a spool on 6 center line of microchannel, and A tune subchannel more corresponding with A entrances 4 than 5 center of coil and main channel connect
Connect place center distance and B tune than 9 center of coil and 7 corresponding subchannel of B entrances with it is equal at a distance from the center of main channel junction
For 2mm.
Embodiment 6
With reference to the structure of embodiment 1, the present embodiment and the difference of embodiment 1 are that mixing plane coil group 12 is by 40
Planar coil is serially connected, and the vertical range at each hub of a spool and main channel center is 2mm.
Embodiment 7
With reference to the structure of embodiment 1, the present embodiment and the difference of embodiment 1 are that A tune is than coil 5, B tune than 9 and of coil
Diameter of wire is 4 μm in mixing plane coil group 12, and separation is 20 μm, and coil turn is 200 circles.
Embodiment 8
With reference to the structure of embodiment 1, the present embodiment and the difference of embodiment 1 are that A tune is than coil 5, B tune than 9 and of coil
It is separation layer that 12 surface of mixing plane coil group, which is provided with one layer of PDMS thin layer,.
Embodiment 9
With reference to the structure of embodiment 1, the present embodiment and the difference of embodiment 1 are that the distance between two block permanent magnets 10 is
2cm is the poles N towards chip cover board 2.
Claims (10)
1. it is a kind of using magnetic liquid be medium it is controllable tune than microfluidic mixer device, including chip base（1）, chip cover board（2）With
Permanent magnet（10）；Chip cover board（2）It is fitted in chip base（1）On, chip base（1）With chip cover board（2）It is provided with corresponding
Groove, permanent magnet（10）It inlays in a groove, magnetic pole and chip base（1）With chip cover board（2）It is perpendicular；
Chip base（1）It is equipped with microchannel（6）；Chip cover board（2）A is equipped with to export（3）, A entrances（4）, A tune compare coil
（5）, B entrances（7）, B outlet（8）, B tune compare coil（9）, power interface（11）, mixing plane coil group（12）And mixed export
（13）；
Microchannel（6）Including four subchannels and a main channel；One end of four subchannels is connected to main channel, the other end
By being opened in chip cover board（2）On conical through-hole be in communication with the outside, respectively be A outlet（3）, A entrances（4）, B entrances
（7）It is exported with B（8）；Main channel one end is connected to four subchannels, and the other end runs through magnetic control mixed zone（15）, at proximal end
For serpentine bend, geometry mixed zone is formed（14）, end is by being opened in chip cover board（2）On conical through-hole mixed export（13）
It is in communication with the outside；It is exported in A（3）Corresponding subchannel and A entrances（4）Channel between corresponding subchannel is equipped with A tune ratios
Coil（5）, in B entrances（7）Corresponding subchannel is exported with B（8）Compare coil equipped with B tune in channel between corresponding subchannel
（9）, A tune compares coil（5）Compare coil with B tune（9）For planar coil, A tune compares coil（5）Compare coil with B tune（9）Respectively from beginning
A conducting wire is respectively drawn with terminal and is located at chip cover board（2）The power interface of both sides（11）Connection, each adjust are distinguished than coil
It is independently-powered by external power supply；
The magnetic control mixed zone（15）Including being located at microchannel（6）The mixing plane coil group of main channel both sides（12）And permanent magnetism
Iron（10）；Mixing plane coil group（12）It is composed in series by multiple planar coils, is arranged symmetrically in main channel both sides, the same side
Planar coil electric current loop is identical around direction, and with offside electric current loop around direction on the contrary, from the beginning of first coil and last
The terminal of a coil respectively draws a conducting wire and is respectively connected to be located at chip cover board（2）On the power interface of both sides, by external power supply
The electric current of direction mechanical periodicity is provided；Permanent magnet（10）It is two pieces, is arranged symmetrically in mixing plane coil group（12）Both sides, two
Block permanent magnet（10）Pole orientation it is identical.
2. controllable tune according to claim 1 is than microfluidic mixer device, which is characterized in that chip base（1）With chip cover board
（2）It is that transparent silicon chip is made, is bonded by the method for bonding.
3. controllable tune according to claim 1 is than microfluidic mixer device, which is characterized in that microchannel（6）Section is pros
Shape, the section length of side are 20 ~ 500 μm.
4. controllable tune according to claim 1 is than microfluidic mixer device, which is characterized in that microchannel（6）It is mixed in geometry
Area（14）Place is serpentine bend, and a diameter of 0.5 ~ 1mm of bend, bend quantity is 5 ~ 20.
5. controllable tune according to claim 1 is than microfluidic mixer device, which is characterized in that A tune compares coil（5）Compare line with B tune
Circle（9）Hub of a spool in the channel on heart line, and A tune compares coil（5）Center and A entrances（4）Corresponding subchannel and master are logical
The distance and B tune at road junction center compare coil（9）Center and B entrances（7）Corresponding subchannel and main channel junction center
Distance be 1 ~ 2mm.
6. controllable tune according to claim 1 is than microfluidic mixer device, which is characterized in that mixing plane coil group（12）By 10
~ 40 planar coils are composed in series.
7. controllable tune according to claim 1 is than microfluidic mixer device, which is characterized in that mixing plane coil group（12）In it is each
The vertical range at hub of a spool and main channel center is 1 ~ 2mm.
8. controllable tune according to claim 1 is than microfluidic mixer device, which is characterized in that A tune compares coil（5）, B tune compare coil
（9）With mixing plane coil group（12）Middle diameter of wire is 2 ~ 4 μm, and separation is 2 ~ 20 μm, and coil turn is 50 ~ 200
Circle.
9. controllable tune according to claim 1 is than microfluidic mixer device, which is characterized in that A tune compares coil（5）, B tune compare coil
（9）With mixing plane coil group（12）Surface is additionally provided with separation layer.
10. controllable tune according to claim 1 is than microfluidic mixer device, which is characterized in that permanent magnet（10）For bar magnet,
Length is slightly larger than mixing plane coil group（12）Length；Two block permanent magnets（10）Between distance be 1 ~ 2cm；Permanent magnet（10）In
Heart face and mixing plane coil group（12）In the same plane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820100160.7U CN208082371U (en) | 2018-01-22 | 2018-01-22 | It is a kind of using magnetic liquid be medium it is controllable tune than microfluidic mixer device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820100160.7U CN208082371U (en) | 2018-01-22 | 2018-01-22 | It is a kind of using magnetic liquid be medium it is controllable tune than microfluidic mixer device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208082371U true CN208082371U (en) | 2018-11-13 |
Family
ID=64066064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201820100160.7U Expired - Fee Related CN208082371U (en) | 2018-01-22 | 2018-01-22 | It is a kind of using magnetic liquid be medium it is controllable tune than microfluidic mixer device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN208082371U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108211960A (en) * | 2018-01-22 | 2018-06-29 | 昆明理工大学 | It is a kind of to be adjusted by the controllable of medium of magnetic liquid than microfluidic mixer device |
-
2018
- 2018-01-22 CN CN201820100160.7U patent/CN208082371U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108211960A (en) * | 2018-01-22 | 2018-06-29 | 昆明理工大学 | It is a kind of to be adjusted by the controllable of medium of magnetic liquid than microfluidic mixer device |
| CN108211960B (en) * | 2018-01-22 | 2023-11-21 | 昆明理工大学 | Controllable ratio-regulating micro-flow mixer using magnetic liquid as medium |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106593831B (en) | A kind of contactless electromagnetism Micropump device | |
| US20090078614A1 (en) | Method and apparatus for separating particles, cells, molecules and particulates | |
| CN113333040B (en) | Micro-fluidic device for converging high-integration-degree micro-nano particles by utilizing oscillatory flow | |
| CN105842324B (en) | A kind of integrated microfluidic chip and its working method | |
| CN108211960A (en) | It is a kind of to be adjusted by the controllable of medium of magnetic liquid than microfluidic mixer device | |
| CN108397373B (en) | Valveless electromagnetic micropump and manufacturing method thereof | |
| CN208082371U (en) | It is a kind of using magnetic liquid be medium it is controllable tune than microfluidic mixer device | |
| CN207894807U (en) | A kind of biochemical analyser based on magnetic bead | |
| Alnaimat et al. | Magnetophoresis and microfluidics: A great union | |
| CN103331121B (en) | Minisize fluid hybrid system | |
| Su et al. | Magnetophoresis in microfluidic lab: Recent advance | |
| CN101477081A (en) | Micro-machining surface finishing method based on bead fixation and microchip structure | |
| CN209451870U (en) | A kind of micro fluidic device for realizing dual drop sorting based on magnetic manipulation | |
| Chong et al. | Design and operation of magnetophoretic systems at microscale: device and particle approaches | |
| CN109529961B (en) | Micro-fluidic device for converging micro-nano biological particles by utilizing oscillatory flow and negative magnetophoresis effect | |
| CN104923322B (en) | A kind of dielectrophoretic particles sorting micro-fluidic chip | |
| CN107051304A (en) | A kind of active electric osmose micro-mixer of unsymmetric structure and electrode | |
| CN113797985A (en) | Micro-nano biological particle enrichment and separation device based on acoustophoresis and oscillatory flow effects | |
| CN105772123B (en) | A kind of magnetism separate method and device based on microfluidic channel | |
| CN113351265B (en) | Processing method of micro-wire magnetic field-driven microfluid magnetic mixing system | |
| CN204724184U (en) | A kind of dielectrophoretic particles sorting micro-fluidic chip | |
| CN104165788B (en) | A kind of continuous flowing separating device of nanometer magnetic bead and method | |
| CN100427194C (en) | Microfluid dynamic mixer, mixing pond mould in chip and driving method thereof | |
| CN203965212U (en) | A kind of nanometer magnetic bead continuous flow tripping device | |
| CN205146262U (en) | Little hybrid chip of high flux based on exchange electric heat |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20181113 Termination date: 20200122 |