CN207330806U - A kind of device for purifying rabbit immunoglobulin - Google Patents
A kind of device for purifying rabbit immunoglobulin Download PDFInfo
- Publication number
- CN207330806U CN207330806U CN201721277091.9U CN201721277091U CN207330806U CN 207330806 U CN207330806 U CN 207330806U CN 201721277091 U CN201721277091 U CN 201721277091U CN 207330806 U CN207330806 U CN 207330806U
- Authority
- CN
- China
- Prior art keywords
- cavity
- packing
- rabbit immunoglobulin
- sap cavity
- conduit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
It the utility model is related to a kind of device for purifying rabbit immunoglobulin, it includes packing cavity, the packing cavity is cavity structure, elution sap cavity, balance sap cavity and loading chamber are connected at the top of the packing cavity, the inner cavity chamber of the elution sap cavity, the balance sap cavity and the loading chamber respectively with the packing cavity connects, flow regulator is equipped with respectively at the elution sap cavity, the balance sap cavity, and filtration apparatus is additionally provided with the packing cavity.Beneficial effect is：The purifying of rabbit immunoglobulin can be easily carried out, purification effect is good, pollution caused by avoiding between various reagents.
Description
Technical field
It the utility model is related to a kind of bio-instruments, more particularly to a kind of device for purifying rabbit immunoglobulin.
Background technology
Immunoglobulin is a kind of albumen that can be combined with antigentic specificity, is led in present biotechnology and medical research
Domain, including diagnostic reagent, antibody drug suffer from being widely applied.
The purification devices of immunoglobulin only have a packing cavity at present, and single assembly cannot accommodate various solution, respectively
It can be polluted between solution.
Utility model content
Technical problem to be solved in the utility model is to provide a kind of device for purifying rabbit immunoglobulin, purification effect
It is good, it will not be polluted between each solution, it is easy to operate.
The technical solution that the utility model solves above-mentioned technical problem is as follows：A kind of device for purifying rabbit immunoglobulin,
It is characterised in that it includes packing cavity, the packing cavity is cavity structure, and eluent is connected at the top of the packing cavity
Chamber, balance sap cavity and loading chamber, elution sap cavity, the balance sap cavity and the loading chamber respectively with the packing cavity
Chamber, the elution sap cavity, described balance are equipped with flow regulator at sap cavity, were additionally provided with the packing cavity respectively
Filter device.
The beneficial effects of the utility model are：The purifying of rabbit immunoglobulin can be easily carried out, purification effect is good, keeps away
Pollution caused by exempting between various reagents.
Based on the above technical solutions, the utility model can also do following improvement.
Further, elution sap cavity, the balance sap cavity and the loading chamber by conduit one, conduit two and are led respectively
Packing cavity is connected described in Guan Sanyu.
Beneficial effect using above-mentioned further scheme is each reagent is flowed into packing cavity, and the elution sap cavity, institute
Balance sap cavity is stated not connect mutually with the loading chamber.
Further, the flow regulator is for the flow control valve one on the conduit one and arranged on the conduit
Flow control valve two on two.
Beneficial effect using above-mentioned further scheme is adjusting flow as needed.
Further, the filtration apparatus is upper sieve plate and the lower sieve being respectively fixedly connected with the top and bottom of the packing cavity
Plate.
Beneficial effect using above-mentioned further scheme is that lower sieve plate can prevent the solid matters such as filler from flowing down, upper sieve
Plate can prevent when filler from causing to be inverted situations such as solid matter is being carried the solid matter such as filler backflow to the elution sap cavity,
The balance sap cavity and the loading intracavitary.
Further, the bottom of the packing cavity is equipped with discharge pipe, and the bottom of the discharge pipe is removably connected with able to turn on or off
Lid.
Beneficial effect using above-mentioned further scheme is that reagent can be discharged from discharge pipe, and lid can close discharge pipe
Or open, start or stop at any time purification process.
Further, the packing cavity is cylindrical shape, and the diameter of the discharge pipe is less than the diameter of the packing cavity.
Beneficial effect using above-mentioned further scheme is, easy to keep less flow.
Further, the packing cavity inner tight is filled with the filler that can be specifically bound with rabbit immunoglobulin.
Beneficial effect using above-mentioned further scheme is fully to be specifically bound with rabbit immunoglobulin.
Brief description of the drawings
Fig. 1 is a kind of structure diagram figure of device for purifying rabbit immunoglobulin provided by the utility model.
In attached drawing, parts list represented by the reference numerals is as follows：
1st, packing cavity, 2, elution sap cavity, 3, balance sap cavity, 4, loading chamber, 5, conduit one, 6, flow control valve one, 7, lead
Pipe two, 8, flow control valve two, 9, conduit three, 10, filler, 11, upper sieve plate, 12, lower sieve plate, 13 lids.
Embodiment
The principle and feature of the utility model are described below in conjunction with attached drawing, example is served only for explaining this practicality
It is new, it is not intended to limit the scope of the utility model.
A kind of as shown in Figure 1, device for purifying rabbit immunoglobulin, it is characterised in that including packing cavity 1, the filler
Chamber 1 is cavity structure, and the top of the packing cavity 1 is connected to elution sap cavity 2, balance sap cavity 3 and loading chamber 4, described
The inner cavity chamber of elution sap cavity 2, the balance sap cavity 3 and the loading chamber 4 respectively with the packing cavity 1 connects, the eluent
Flow regulator is respectively equipped with chamber 2, the balance sap cavity 3, filtration apparatus is additionally provided with the packing cavity 1.
Elution sap cavity 2, the balance sap cavity 3 and the loading chamber 4 pass through conduit 1, conduit 27 and conduit respectively
39 are connected with the packing cavity 1.
The flow regulator is for the flow control valve 26 on the conduit 1 and on the conduit 27
Flow control valve 28.
The filtration apparatus is upper sieve plate 11 and the lower sieve plate being respectively fixedly connected with the top and bottom of packing cavity 1
12。
The bottom of the packing cavity 1 is equipped with discharge pipe, and the bottom of the discharge pipe is removably connected with lid able to turn on or off
13。
The packing cavity 1 is cylindrical shape, and the diameter of the discharge pipe is less than the diameter of the packing cavity 1.
1 inner tight of packing cavity is filled with the filler 10 that can be specifically bound with rabbit immunoglobulin.Filler
10 can be Protein A, Protein G.
Application method：
Flow control valve 28 is opened, the equilibrium liquid in balance sap cavity 3 is flowed out to packing cavity 1 by conduit 27,
Discharged from discharge pipe, clean 1 volume of general two packing cavities, close flow control valve 28.Liquid to be purified is added to loading
Chamber 4, packing cavity 1 is flowed out to by conduit 39.Flow control valve 28 is again turned on, passes through the equilibrium liquid in balance sap cavity 3
Conduit 27 can flow out to packing cavity 1, clean 1 volume of general three packing cavities, close flow control valve 28.Open flow tune
Valve 1 is saved, the equilibrium liquid in elution sap cavity 2 is flowed out to packing cavity 1 by conduit 1, is discharged from discharge pipe, and start
Efflux is received, efflux is the rabbit immunoglobulin purified.
The above is only the preferred embodiment of the present invention, is not intended to limit the utility model, all in this practicality
Within new spirit and principle, any modification, equivalent replacement, improvement and so on, should be included in the guarantor of the utility model
Within the scope of shield.
Claims (7)
1. a kind of device for purifying rabbit immunoglobulin, it is characterised in that including packing cavity (1), the packing cavity (1) is hollow
Cavity configuration, elution sap cavity (2), balance sap cavity (3) and loading chamber (4) are connected at the top of the packing cavity (1), described to wash
De- sap cavity (2), the balance sap cavity (3) and inner cavity chamber of the loading chamber (4) respectively with the packing cavity (1) connect, described
Elution sap cavity (2), described balance sap cavity (3) place are respectively equipped with flow regulator, and filtering dress is additionally provided with the packing cavity (1)
Put.
A kind of 2. device for purifying rabbit immunoglobulin according to claim 1, it is characterised in that the elution sap cavity (2),
The balance sap cavity (3) and the loading chamber (4) are filled out by conduit one (5), conduit two (7) and conduit three (9) with described respectively
Material chamber (1) is connected.
A kind of 3. device for purifying rabbit immunoglobulin according to claim 2, it is characterised in that the flow regulator
For the flow control valve one (6) on the conduit one (5) and the flow control valve two (8) on the conduit two (7).
4. a kind of device for purifying rabbit immunoglobulin according to claim 1, it is characterised in that the filtration apparatus is point
The upper sieve plate (11) and lower sieve plate (12) not being fixedly connected at the top and bottom of the packing cavity (1).
5. a kind of device for purifying rabbit immunoglobulin according to claim 1, it is characterised in that the packing cavity (1)
Bottom is equipped with discharge pipe, and the bottom of the discharge pipe is removably connected with lid able to turn on or off (13).
6. a kind of device for purifying rabbit immunoglobulin according to claim 5, it is characterised in that the packing cavity (1) is
Cylindrical shape, the diameter of the discharge pipe are less than the diameter of the packing cavity (1).
7. according to a kind of any one of claim 1-6 devices for purifying rabbit immunoglobulin, it is characterised in that the filler
Chamber (1) inner tight is filled with the filler (10) that can be specifically bound with rabbit immunoglobulin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721277091.9U CN207330806U (en) | 2017-09-30 | 2017-09-30 | A kind of device for purifying rabbit immunoglobulin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721277091.9U CN207330806U (en) | 2017-09-30 | 2017-09-30 | A kind of device for purifying rabbit immunoglobulin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207330806U true CN207330806U (en) | 2018-05-08 |
Family
ID=62367803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721277091.9U Expired - Fee Related CN207330806U (en) | 2017-09-30 | 2017-09-30 | A kind of device for purifying rabbit immunoglobulin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207330806U (en) |
-
2017
- 2017-09-30 CN CN201721277091.9U patent/CN207330806U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180508 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |