CN207143243U - A kind of cellular-type purging system with real time monitoring function - Google Patents

Abstract

The utility model discloses a kind of cellular-type purging system with real time monitoring function, it is related to biological material deal device technical field.Invented to solve the problems, such as that prior art takes off cell device and can not adapt to produce and be unable to reach optimal de- cell effect in enormous quantities.The utility model has the cellular-type purging system of real time monitoring function, including shaking table, the shaking table includes swinging pallet, the swing pallet is provided with cleaning case, the cleaning case includes multiple rinse baths, and the rinse bath is used to place biomaterial and de- cell reagent, in addition to detection means, the detection means includes concentration detector, the concentration of the detectable de- cell reagent of the concentration detector.The cellular-type purging system that the utility model has real time monitoring function can be used for biomaterial to take off cell.

Description

A kind of cellular-type purging system with real time monitoring function

Technical field

It the utility model is related to biological material deal device technical field, more particularly to it is a kind of with real time monitoring function Cellular-type purging system.

Background technology

With the development of economy and society, the application of biomaterial medically also seems more and more prominent, biomaterial Refer to the process of the material formed by biology, including cell and extracellular matrix.Conventional biomaterial have bovine pericardium and Chitterlings, when biomaterial is applied into clinical, it is necessary to be cleaned to biomaterial, the processing such as sterilizing, de- cell Process.

In the prior art, generally use shaking table carries out de- cell, specifically, a cleaning is fixed on the pallet of shaking table Box, biomaterial and de- cell reagent are put into cleaning box, are then turned on shaking table and are vibrated, in oscillatory process, cleaning Box inwall is flopped repeatedly to biomaterial, so as to realize the de- cell of biomaterial.

But because the oscillation amplitude of shaking table limits, the volume of cleaning box can not be made big, can make if volume is too big Cleaning box two lateral walls spacing it is very big, thus, biomaterial cleaning box vibrate during also not with cleaning box Inwall produces slap, and just warp-wise opposite direction has been moved, so as to realize de- cell.Therefore, the de- cell cleaning of prior art Box, in order to adapt to the oscillation amplitude of shaking table, usual volume is all smaller, can not adapt to produce in enormous quantities.Also, carrying out de- cell During, de- cell reagent can change, and the scheme of prior art can not grasp the situation of change of de- cell reagent in real time, Also the adjustment of adaptability can not be just carried out to taking off cell reagent, so as to be unable to reach optimal de- cell effect.

Utility model content

Embodiment of the present utility model provides a kind of cellular-type purging system with real time monitoring function, can supervise in real time The situation of change of de- cell reagent is surveyed, consequently facilitating carrying out the adjustment of adaptability to taking off cell reagent, improves de- cell effect.

To reach above-mentioned purpose, it is clear that embodiment of the present utility model provides a kind of cellular-type with real time monitoring function System, including shaking table are washed, the shaking table includes swinging pallet, and the swing pallet is provided with cleaning case, and the cleaning case includes Multiple rinse baths, the rinse bath are used to place biomaterial and de- cell reagent, in addition to detection means, the detection means Including concentration detector, the concentration of the detectable de- cell reagent of the concentration detector.

The utility model has the cellular-type purging system of real time monitoring function, because the cleaning case includes multiple cleanings Groove, therefore, the volume of each rinse bath can be made as adapting to the maximum volume of shaking table oscillation amplitude, one with prior art Cleaning box is compared, and increases the processing quantity of biomaterial.And to include dense because there is provided detection means, the detection means Detector is spent, the concentration of the detectable de- cell reagent of the concentration detector, thus, the dense of de- cell reagent can be monitored in real time Degree, when the concentration of de- cell reagent is excessive or during saturation, new de- cell reagent can be added, so as to improve de- cell efficiency.

Brief description of the drawings

, below will be to embodiment in order to illustrate more clearly of the utility model embodiment or technical scheme of the prior art Or the required accompanying drawing used is briefly described in description of the prior art, it should be apparent that, drawings in the following description are only It is some embodiments of the utility model, for those of ordinary skill in the art, is not paying the premise of creative work Under, other accompanying drawings can also be obtained according to these accompanying drawings.

Fig. 1 is the overall structure diagram of the utility model embodiment cellular-type purging system；

Fig. 2 is the internal structure schematic diagram of the utility model embodiment cellular-type purging system；

Fig. 3 is the composition frame chart of the detection means of the utility model embodiment cellular-type purging system；

Fig. 4 is the structural representation of the interior layer box body of the utility model embodiment cellular-type purging system；

Fig. 5 is the polycrystalline substance schematic diagram of the interior layer box body of the utility model embodiment cellular-type purging system.

Embodiment

Below in conjunction with the accompanying drawing in the utility model embodiment, the technical scheme in the embodiment of the utility model is carried out Clearly and completely describing, it is clear that described embodiment is only the utility model part of the embodiment, rather than whole Embodiment.Based on the embodiment in the utility model, those of ordinary skill in the art are not under the premise of creative work is made The every other embodiment obtained, belong to the scope of the utility model protection.

In description of the present utility model, it is to be understood that term " " center ", " on ", " under ", "front", "rear", The orientation or position relationship of the instruction such as "left", "right", " vertical ", " level ", " top ", " bottom ", " interior ", " outer " is based on accompanying drawing institutes The orientation or position relationship shown, it is for only for ease of description the utility model and simplifies description, rather than indicates or imply and be signified Device or element must have specific orientation, with specific azimuth configuration and operation, therefore it is not intended that to this practicality New limitation.In description of the present utility model, unless otherwise indicated, " multiple " are meant that two or more.

Reference picture 1, Fig. 2, Fig. 1 and Fig. 2 are the cellular-type cleaning system that the utility model embodiment has real time monitoring function One specific embodiment of system, the cellular-type purging system with real time monitoring function of the present embodiment, including shaking table 3, it is described Shaking table 3 includes swinging pallet, and the swing pallet is provided with cleaning case, and the cleaning case includes multiple rinse baths 21, described clear Washing trough 21 is used to place biomaterial and de- cell reagent, in addition to detection means 4, and the detection means 4 includes Concentration Testing Device, the concentration of the detectable de- cell reagent of the concentration detector.

The cellular-type purging system with real time monitoring function that the utility model embodiment provides, due to the cleaning case Including multiple rinse baths 21, therefore, the volume of each rinse bath 21 can be made as adapting to the largest body of the oscillation amplitude of shaking table 3 Product, compared with a cleaning box of prior art, increases the processing quantity of biomaterial.And because there is provided detection means 4, the detection means 4 includes concentration detector, and the concentration of the detectable de- cell reagent of the concentration detector thus, can be real When monitor the concentration of de- cell reagent, when the concentration of de- cell reagent is excessive or during saturation, can add new de- cell reagent, from And improve de- cell efficiency.

In order to more fully detect the parameters of de- cell reagent, it is preferable that as shown in figure 3, the detection means 4 is also Including pH sensor and temperature detector, the pH value of the detectable de- cell reagent of the pH sensor.The temperature detection The temperature of the detectable de- cell reagent of device.Thus, the parameters situation of change of de- cell reagent can be grasped comprehensively, in time will be de- The parameters of cell reagent are adjusted to most suitable scope.

For the ease of discharge opeing, as shown in Figure 1, Figure 2, Figure 4 shows, the cleaning case includes outer-layer box body 1 and is arranged at described outer Interior layer box body 2 in layer box body 1, the interior layer box body 2 can be with the synchronized oscillation of outer-layer box body 1, the outer-layer box body 1 and the pendulum Dynamic pallet connection, the interior layer box body 2 is interior to be provided with dividing plate 25, and the space in the interior layer box body 2 is divided into by the dividing plate 25 Multiple rinse baths 21, the outer-layer box body 1 are connected with discharging tube 11, the discharging tube 11 and the bottom of the outer-layer box body 1 Portion space connects, and each rinse bath 21 is equipped with outage 211, the outage 211 and the bottom of the outer-layer box body 1 Space connects, the outage 211 allow de- cell reagent by and do not allow biomaterial to pass through.Thus, in discharge opeing, only Discharging tube 11 need to be opened, the de- cell reagent in rinse bath 21 can be discharged by discharging tube 11, without dismantling outer-layer box body 1 and interior Layer box body 2, simple to operate, production efficiency is high.

Wherein, in order to realize synchronized oscillation of the interior layer box body 2 with outer-layer box body 1, can by the inside dimension of outer-layer box body 1 and The external dimensions of interior layer box body 2 matches, i.e., when interior layer box body 2 is installed in outer-layer box body 1, the madial wall of outer-layer box body 1 It is bonded to each other between the lateral wall of interior layer box body 2, so that outer-layer box body 1, during vibration, interior layer box body 2 can not Moved relative to outer-layer box body 1, avoid producing shock between outer-layer box body 1 and interior layer box body 2.Alternatively, it is also possible in outer layer case Location structure is set between body 1 and interior layer box body 2, by location structure prevent in layer box body 2 moved relative to outer-layer box body 1, Such as rubber blanket can be set between outer-layer box body 1 and interior layer box body 2, outer-layer box body 1 is fixed in one end of rubber blanket On madial wall, the lateral wall of the other end and interior layer box body 2 is against or one end of rubber blanket being fixed on to the outside of interior layer box body 2 On wall, the madial wall of the other end and outer-layer box body 1 against.Interior layer box body 2 synchronously shaking with outer-layer box body 1 can equally be realized Swing.

Wherein, the arrangement mode of multiple rinse baths 21 can have a variety of, such as can be along same linear array into one Row, can also be by multiple rinse baths 21 along rectangular array.It is overall by the rinse bath of rectangular array compared to along linear array More compact structure, deformation is not easy during vibration.For example, as shown in figure 1, the dividing plate 25 divides the space in the interior layer box body 2 16 rinse baths are divided into, 16 rinse bath arrays are that 4 rows 4 arrange.Equally, dividing plate 25 can also be by the sky in interior layer box body 2 Between be divided into 9 rinse baths, 9 rinse bath arrays are that 3 rows 3 arrange.Specifically how to split and arrange can be according to actual conditions Selected, do not limited herein.

As shown in figure 4, the upper surface both sides of interior layer box body 2 are provided with handle 22, so as to conveniently by interior layer box body 2 by outer layer case Take out in body 1, be easy to internal layer box body 2 to carry out disinfection sterilization and cleaning treatment.

Specifically, interior layer box body 2 can use structure as shown in Figure 4, Figure 5, i.e., including bottom plate 23 and around the bottom 23 1 weeks side plates 24 set of plate, the interior layer box body 2 is interior to be provided with dividing plate 25, and the dividing plate 25 is by the interior layer box body 2 Space is divided into multiple rinse baths 21.Alternatively, it is also possible to not use dividing plate 25, directly placed in interior layer box body 2 multiple Independent rinse bath 21, multiple lateral walls of rinse bath 21 are bonded each other to be closely arranged in interior layer box body 2.Scheme shown in Fig. 4 It is simple in construction and low therefore relatively more economical and practical to making required precision.

In order to facilitate liquid feeding, as shown in figure 4, it is preferred that open up intercommunicating pore 251 in the lower end of dividing plate 25, it is two neighboring described clear Washing trough 21 is connected by the intercommunicating pore 251.Thus, when adding de- cell reagent, it is not necessary to add one by one into rinse bath 21 Enter, only need to add de- cell reagent to a rinse bath 21, de- cell reagent is flowed into other rinse baths 21 by intercommunicating pore 251 .And this scheme may be such that de- cell reagent dosage in each rinse bath 21 and concentration are equal, ensure with a collection of clear The de- cell effect for the biomaterial washed is consistent.

As shown in figure 4, the setting for one week around rinse bath 21 of intercommunicating pore 251, and vertically it is provided with two rows.Connection Hole 251 should not open up excessively, preferably vertically set 1~3 row, if dividing plate 25 can excessively be reduced to liquid by setting Flop power so that liquid drives the movement velocity of biomaterial to reduce, so as to reduce the bat between biomaterial and dividing plate 25 Power is hit, de- cell effect can be influenceed.

Wherein, the set-up mode of outage 211 can have multiple choices, in a kind of embodiment of the present utility model, such as Shown in Fig. 5, outage 211 is distributed on the bottom plate 23 of interior layer box body 2, and respectively at multiple correspondences of rinse bath 21, interior layer box body 2 Bottom plate 23 and the bottom plate 12 of the outer-layer box body 1 between formed with connecting chamber 28, it is more on the bottom plate 23 of the interior layer box body 2 The individual outage 211 connects with the chamber 28 that connects.Thus, in discharge opeing, after opening discharging tube 11, in rinse bath 21 Liquid is discharged by connection chamber 28 and discharging tube 11 successively, easy to operate, it is not necessary to layer box body 2 in dismounting.

In the above-described embodiments, connection chamber 28 can have a variety of implementations, for example, as shown in Fig. 2 can be in internal layer case Support member 27 is set between the bottom plate 23 of body 2 and the bottom plate 12 of outer-layer box body 1, by support member 27 by the bottom plate of interior layer box body 2 23 separate with the bottom plate 12 of outer-layer box body 1, make to be formed between the bottom plate 23 of interior layer box body 2 and the bottom plate 12 of outer-layer box body 1 and connect Chamber 28.Equally, hanging structure can also be set between the side wall of interior layer box body 2 and the side wall of outer-layer box body 1, makes interior layer box body 2 are vacantly mounted in outer-layer box body 1, formation between the bottom plate 23 of interior layer box body 2 and the bottom plate 12 of outer-layer box body 1 is connected chamber 28。

In another embodiment of the present utility model, outage 211 can also be distributed in the side plate 24 of interior layer box body 2 On, as shown in figure 4, the lower end of the dividing plate 25 offers intercommunicating pore 251, the two neighboring rinse bath 21 passes through the connection Hole 251 connects, and outage 211 is opened in the lower end of the side plate 24.Thus, in discharge opeing, after opening discharging tube 11, in being located at Liquid in the rinse bath 21 in portion first passes through intercommunicating pore 251 and flowed into outermost rinse bath 21, then passes through the lower end of side plate 24 Outage 211 be discharged into outer-layer box body 1, finally discharged by discharging tube 11, this scheme is again without layer box body in dismounting 2.

It should be noted that the plan of establishment of above two outage 211 can only with one kind, can also two kinds simultaneously Using.When only with the first scheme, when beginning to rehearse fluid apertures 211 on the bottom plate 23 of interior layer box body 2, outage 211 is easily given birth to Thing material blocks, and discharge opeing is ineffective, therefore preferably two schemes use simultaneously.

Wherein, the diameter of outage 211 preferably uses 3 millimeters, biomaterial is easily caught in if aperture is too big, if aperture Too small then drain age velocity is too slow.

Wherein, the horizontal cross-section of rinse bath 21 can be rectangle, square, polygon circle etc., not limit herein. Because the oscillation amplitude of typically conventional shaking table 3 is 30~60 millimeters, in order to ensure that rinse bath 21 can adapt to the vibration of shaking table 3 Amplitude, preferably the full-size of the rinse bath 21 in the horizontal direction is set smaller than or equal to 300 millimeters.For example, cleaning When groove 21 is rectangle, the width of rinse bath 21 can be arranged to 140 millimeters, length is arranged to 230 millimeters.

Preferably, the height of the rinse bath 21 vertically should be greater than or equal to 100 millimeters, such as height may be selected For 250 millimeters, it thus can prevent the liquid in rinse bath 21 from being spilt in vibration.

Discharge, the bottom plate 12 of the outer-layer box body 1 can be obliquely installed for the ease of liquid, and the outer-layer box body 1 The minimum point of bottom plate 12 is set close to the discharging tube 11.Thus, it may be such that de- cell reagent in outer-layer box body 1 along inclined-plane stream Move to the porch of discharging tube 11, so as to prevent the de- cell reagent of the bottom of outer-layer box body 1 residual.

In the oscillatory process of shaking table 3, biomaterial is easily got rid of to the opening of interior layer box body 2, and is ridden on dividing plate 25 Edge, so that the biomaterial can not complete de- cell, as shown in Fig. 2 in order to avoid above mentioned problem, can be in the internal layer The opening of casing 2 sets internal layer case lid 26, and the internal layer case lid 26 is arranged into plate-like structure, the side plate 24 and institute State dividing plate 25 upper edge be generally aligned in the same plane in, the internal layer case lid 26 is covered on the side plate 24 and the dividing plate 25. Thus, the upper edge of internal layer case lid 26 and side plate 24 and the dividing plate 25 is brought into close contact so that biomaterial can not ride over dividing plate 25 or the upper edge of side plate 24.

For the ease of the situation in observation rinse bath 21, preferably the internal layer case lid 26 is made of transparent material.By This, can observe the situation in rinse bath 21 by internal layer case lid 26, as foam how much, height of liquid level, biomaterial state etc..If Abnormal conditions occur can find in time.

In addition, as shown in figure 1, outer layer case lid 13 can also be set in the opening of outer-layer box body 1, so as to prevent the external world miscellaneous Matter enters in de- cell reagent, pollutes biomaterial.

Preferably, the outer-layer box body 1 for taking off cell net cage is fixed on swing pallet by interface arrangment, such as Fig. 1 institutes Show, the bottom surface of shaking table 3 is provided with retractable roller 31, facilitates the carrying of shaking table 3.

It is described above, only specific embodiment of the present utility model, but the scope of protection of the utility model is not limited to In this, any one skilled in the art can readily occur in change in the technical scope that the utility model discloses Or replace, it should all cover within the scope of protection of the utility model.Therefore, the scope of protection of the utility model should be with the power The protection domain that profit requires is defined.

Claims (10)

1. a kind of cellular-type purging system with real time monitoring function, it is characterised in that including shaking table, the shaking table includes pendulum Dynamic pallet, the swing pallet are provided with cleaning case, and the cleaning case includes multiple rinse baths, and the rinse bath is used to place life Thing material and de- cell reagent, in addition to detection means, the detection means are arranged in the cleaning case, the detection means Including concentration detector, the concentration of the detectable de- cell reagent of the concentration detector.

2. the cellular-type purging system according to claim 1 with real time monitoring function, it is characterised in that the detection Device also includes pH sensor, the pH value of the detectable de- cell reagent of the pH sensor.

3. the cellular-type purging system according to claim 1 with real time monitoring function, it is characterised in that the detection Device also includes temperature detector, the temperature of the detectable de- cell reagent of the temperature detector.

4. according to the cellular-type purging system according to any one of claims 1 to 3 with real time monitoring function, its feature exists In the cleaning case includes outer-layer box body and the interior layer box body being arranged in the outer-layer box body, and the interior layer box body can be with outer Layer box body synchronized oscillation, the outer-layer box body are connected with the shaking table, are provided with dividing plate in the interior layer box body, and the dividing plate is by institute State the space in interior layer box body and be divided into multiple rinse baths, the outer-layer box body is connected with discharging tube, the discharging tube with The bottom space connection of the outer-layer box body, each rinse bath are equipped with outage, the outage and the outer layer case The bottom space connection of body, the outage allow de- cell reagent by and do not allow biomaterial to pass through.

5. the cellular-type purging system according to claim 4 with real time monitoring function, it is characterised in that the internal layer Casing includes bottom plate and is arranged at around one week side plate set of bottom plate, the dividing plate on the bottom plate, and the outage is more Individual, at least a portion outage is opened on the bottom plate of the interior layer box body, the bottom plate of the interior layer box body with it is described outer Formed with connection chamber between the bottom plate of layer box body, multiple outages on the bottom plate of the interior layer box body pass through the connection Chamber connects.

6. the cellular-type purging system according to claim 5 with real time monitoring function, it is characterised in that the dividing plate Lower end offer intercommunicating pore, the two neighboring rinse bath is connected by the intercommunicating pore.

7. the cellular-type purging system according to claim 6 with real time monitoring function, it is characterised in that at least one The outage is divided to be opened in the lower end of the side plate.

8. the cellular-type purging system according to claim 4 with real time monitoring function, it is characterised in that the outer layer The bottom plate of casing is obliquely installed, and the minimum point of the bottom plate of the outer-layer box body is set close to the discharging tube.

9. the cellular-type purging system according to claim 4 with real time monitoring function, it is characterised in that the internal layer The opening of casing is provided with internal layer case lid, and the internal layer case lid is made of clear material.

10. according to the cellular-type purging system according to any one of claims 1 to 3 with real time monitoring function, its feature It is, the full-size of the rinse bath horizontal direction is less than or equal to 300 millimeters, the height of the rinse bath vertically More than or equal to 100 millimeters.