CN206687691U - A kind of reflective confocal microscopic image system - Google Patents
A kind of reflective confocal microscopic image system Download PDFInfo
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- CN206687691U CN206687691U CN201621360140.0U CN201621360140U CN206687691U CN 206687691 U CN206687691 U CN 206687691U CN 201621360140 U CN201621360140 U CN 201621360140U CN 206687691 U CN206687691 U CN 206687691U
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Abstract
The utility model provides a kind of reflective confocal microscopic image system, fibre bundle module, quarter wave plate, object lens are contained in the optical fiber flexible pipe of integration, and combine conjugate focus imaging technique, so as to realize reflective confocal microscopic image system compact, portability, doctor flexibly can detect to patient's lesion region simultaneously, the spacing shortcoming of Universal arm is no longer limited by, its is in light weight, using the free degree is big, image resolution ratio is high.
Description
Technical field
Confocal microscopic image system design and manufacturing field are the utility model is related to, more particularly, to a kind of reflective common
Focus on micro imaging system.
Background technology
The important tool that the copolymerization of skin Computed tomography, also referred to as skin is burnt, skin CT is disease of skin detection.
It is main at present to use focusing principle altogether, light source illumination sample in wide field is replaced with laser point light source, while use pin before the detectors
Hole forms point detection, and lighting point is conjugated with sensing point relative to focal plane of lens.Point beyond focal plane will not be at sensing point
Imaging, so can effectively suppress the influence of veiling glare.By sweep mechanisms such as galvanometer or displacement platforms, spatially 3-D scanning is formed
Imaging, by obtaining sample 3-D view to the three-dimensional reconstruction of image.
But using some weak points of co-focusing imaging method：1) optical maser wavelength used is relatively fewer, due to skin
Be present larger difference in the diversity of component, absorption reflection characteristic of the various composition to different wave length light wave, can cause using difference
Imaging effect during wavelength is different, and wavelength can not realize optimal imaging effect to specific skin constituents at least；2) imaging is deep
Degree deficiency.Skin co-focusing imaging has certain imaging depth, but maximum can only be still applicable only to 500 μm or so
Body observes epidermis and high dermis, and with the increase of imaging depth, its spatial resolution significantly reduces, and which has limited be focused into altogether
As the application in disease of skin diagnosis.
Fibre optic image transmission technology is a kind of passive device for the transmission image that can arbitrarily bend, with traditional optical image former
Part is compared, have the advantages that it is in light weight, using the free degree it is big, easily realize Complicated Spatial Structure, be widely applied at present.
But fibre optic image transmission technology is combined with reflective focusing technology altogether, and is applied to the rare report of external skin organizational diagnosis
Road.The vivascope small product sizes of LUCID companies of the U.S. are larger, and imaging header structure is more inflexible, can not realize imaging region
Flexibly switching.
Utility model content
Based on this, it is necessary to provide the reflective confocal microscopic image that a kind of portable, imaging region can flexibly switch
System.
To achieve the above object, the utility model uses following technical proposals：
A kind of reflective confocal microscopic image system, including：Laser light source module, polarizer module, PBS light splitting ribs
Mirror, vibration mirror scanning module, scanning lens, optical fiber flexible pipe, fibre bundle module, quarter wave plate, object lens, apeture lens and detecting module；
The polarizer module includes the first polarizer and the second polarizer, and first polarizer and the second polarizer are used
In the incident laser intensity of regulation, fibre bundle module, quarter wave plate and the object lens are contained in optical fiber flexible pipe, the detection mould
The front end face of block is provided with detecting pinhole；
The laser of the laser light source module outgoing enters the PBS points after first polarizer and the second polarizer
Light prism, the PBS Amici prisms are divided to the laser of incidence, and S light is farthest reflected in the galvanometer and swept
Retouch in module；The vibration mirror scanning module carries out spot scan to the laser of incidence, laser is entered the scanning with different angle
Re-incident enters the optical fiber flexible pipe after lens, different with the scanning angle of the vibration mirror scanning module, the optical fiber flexible pipe
The fibre bundle of inner fiber beam module is fired in sequence, the fibre bundle laser is sent to after the quarter wave plate enter back into it is described
Object lens are simultaneously focused on sample by the object lens；
Through laser caused by the sample reflection again successively after the object lens, the quarter wave plate, the fibre bundle module
Incident after the scanning lens to enter the PBS Amici prisms, the PBS Amici prisms transmit laser caused by the reflection, and
Focused on by the apeture lens at the detecting pinhole of the detecting module front end face.
In certain embodiments, the laser light source module is used to provide near infrared ray polarization light source.
In certain embodiments, the vibration mirror scanning module includes resonance galvanometer and galvanometer galvanometer, by described common
Two-dimensional scan is realized in the cooperation of galvanometer and galvanometer galvanometer.
In certain embodiments, incidence enters the end of the fibre bundle of the fibre bundle module after the vibration mirror scanning module
Face section is in main image planes.
In certain embodiments, the detecting module is avalanche diode signal sensor.
In certain embodiments, in addition to signal is connected to the analysis module of the avalanche diode signal sensor, institute
The signal that analysis module is used to obtain the avalanche diode signal sensor detection is stated, and the signal is analyzed.
The utility model uses the advantages of above-mentioned technical proposal to be：
A kind of reflective confocal microscopic image system provided by the utility model, by fibre bundle module, quarter wave plate, thing
Mirror is contained in the optical fiber flexible pipe of integration, and combines conjugate focus imaging technique, so as to realize that reflective copolymerization is burnt micro-
Imaging system miniaturization, portability, while doctor flexibly can detect to patient's lesion region, be no longer limited by universal
The spacing shortcoming of arm, its is in light weight, using the free degree is big, image resolution ratio is high.
Brief description of the drawings
Fig. 1 is the reflective confocal microscopic image system structure diagram that the utility model embodiment provides.
Wherein：Laser light source module 110, polarizer module 120, PBS Amici prisms 130, vibration mirror scanning module 140, sweep
Retouch lens 150, optical fiber flexible pipe 160, fibre bundle module 170, quarter wave plate 180, object lens 190, apeture lens 210, detecting module
220th, the first polarizer 121 and the second polarizer 122, detecting pinhole 221.
Embodiment
The structure that Fig. 1 is the reflective confocal microscopic image system 100 that the utility model embodiment provides is refer to show
It is intended to, including：Laser light source module 110, polarizer module 120, PBS Amici prisms 130, vibration mirror scanning module 140, scanning are saturating
Mirror 150, optical fiber flexible pipe 160, fibre bundle module 170, quarter wave plate 180, object lens 190, apeture lens 210 and detecting module 220.
Wherein：
Laser light source module 110 is used to provide near infrared ray polarization light source.It is appreciated that due to using near infrared ray polarisation
Light source has certain advantage compared to visible light source on imaging depth.
The polarizer module 120 includes the first polarizer 121 and the second polarizer 122.First polarizer 121 and second
The light intensity of laser can be adjusted for polarizer 122, while coordinate quarter wave plate 180 to adjust the quality of laser facula.
PBS Amici prisms 130 are used to be divided laser so that S light is farthest reflected in vibration mirror scanning module
On 140, while reflected light is played through effect.
Vibration mirror scanning module 140 is used to carry out high speed spot scan to laser.Preferably, the vibration mirror scanning module 140 is wrapped
Resonance galvanometer and galvanometer galvanometer are included, two-dimensional scan is realized by the cooperation of the resonance galvanometer and galvanometer galvanometer.Can be with
Understand, coordinated by double galvanometers of the resonance galvanometer and galvanometer galvanometer in the optical system that can effectively reduce redundancy
One group of beam-expanding system.
Fibre bundle module 170, quarter wave plate 180 and object lens 190 are contained in optical fiber flexible pipe 160.It is appreciated that by optical fiber
Beam module 170, quarter wave plate 180 and the envelope of object lens 190 are reflective common so as to realize in the optical fiber flexible pipe 160 of integration
Miniaturization, the portability of micro imaging system are focused on, while doctor flexibly can detect to patient's lesion region, no longer
The spacing shortcoming of Universal arm is limited to, its is in light weight, big using the free degree.
The front end face of detecting module 220 is provided with detecting pinhole 221.Preferably, the detecting module 220 is the pole of snowslide two
Pipe signal sensor.
The reflective confocal microscopic image system 100 that the application provides also is connected to the avalanche diode including signal
The analysis module (not shown) of signal sensor, the analysis module are used to obtain the avalanche diode signal sensor detection
Signal, and the signal is analyzed.
Incorporated by reference to Fig. 1, reflective its operation principle of confocal microscopic image system 100 provided by the utility model is as follows：
The laser that laser light source module 110 is emitted enters described after the polarizer 122 of the first polarizer 121 and second
PBS Amici prisms 130, the PBS Amici prisms 130 are divided to the laser of incidence, and S light is farthest reflected in
In the vibration mirror scanning module 140；The vibration mirror scanning module 140 carries out spot scan to the laser of incidence, makes laser with difference
Re-incident enters the optical fiber flexible pipe 160 after angle enters the scanning lens 150, with the vibration mirror scanning module 150
Scanning angle is different, and the fibre bundle of the inner fiber beam module 170 of optical fiber flexible pipe 160 is fired in sequence, and the fibre bundle will swash
Light enters back into the object lens 190 after being sent to the quarter wave plate 180 and focused on by the object lens 190 on sample；It can manage
Solution, the end face section of the incident fibre bundle for entering the fibre bundle module is in main image planes after the vibration mirror scanning module, this
When, it is necessary to adjust the angle of incident entrance, prevent signal interference and close on fiber-optic signal disturbing phenomenon.
Through laser caused by the sample reflection again successively through the object lens 190, the quarter wave plate 180, the fibre bundle
Incident after the scanning lens 150 after module 170 to enter the PBS Amici prisms 140, the transmission of PBS Amici prisms 140 should
Laser caused by reflection, and focus on by the apeture lens 210 detecting pinhole 221 of the front end face of detecting module 220
Place.
Analysis module obtains the signal that detecting pinhole 221 detects, and the signal is analyzed, and completes to skin
Detection and analysis.
A kind of reflective confocal microscopic image system provided by the utility model, by fibre bundle module 170, quarter wave plate
180th, object lens 190 are contained in the optical fiber flexible pipe 160 of integration, and combine conjugate focus imaging technique, so as to realize reflection
Formula confocal microscopic image system compact, portability, while doctor flexibly can detect to patient's lesion region, no
The spacing shortcoming of Universal arm is limited to again, and its is in light weight, using the free degree is big, image resolution ratio is high.
Certain reflective confocal microscopic image system of the present utility model can also have a variety of conversion and remodeling, not office
It is limited to the concrete structure of above-mentioned embodiment.In a word, it is common for this area should to include those for the scope of protection of the utility model
Obviously convert or substitute and retrofit for technical staff.
Claims (6)
- A kind of 1. reflective confocal microscopic image system, it is characterised in that including：Laser light source module, polarizer module, PBS Amici prisms, vibration mirror scanning module, scanning lens, optical fiber flexible pipe, fibre bundle module, quarter wave plate, object lens, apeture lens and Detecting module；The polarizer module includes the first polarizer and the second polarizer, and first polarizer and the second polarizer are used to adjust Incident laser intensity is saved, fibre bundle module, quarter wave plate and the object lens are contained in optical fiber flexible pipe, the detecting module Front end face is provided with detecting pinhole；The laser of the laser light source module outgoing enters PBS light splitting ribs after first polarizer and the second polarizer Mirror, the PBS Amici prisms are divided to the laser of incidence, and S light is farthest reflected in the vibration mirror scanning mould On block；The vibration mirror scanning module carries out spot scan to the laser of incidence, laser is entered the scanning lens with different angle Re-incident enters the optical fiber flexible pipe afterwards, different with the scanning angle of the vibration mirror scanning module, light in the optical fiber flexible pipe The fibre bundle of fine beam module is fired in sequence, and laser is sent to after the quarter wave plate and enters back into the object lens by the fibre bundle And focused on by the object lens on sample；Through laser caused by the sample reflection again successively after the object lens, the quarter wave plate, the fibre bundle module it is described Incident after scanning lens to enter the PBS Amici prisms, the PBS Amici prisms transmit laser caused by the reflection, and pass through The apeture lens is focused at the detecting pinhole of the detecting module front end face.
- 2. reflective confocal microscopic image system according to claim 1, it is characterised in that the laser light source module For providing near infrared ray polarization light source.
- 3. reflective confocal microscopic image system according to claim 1, it is characterised in that the vibration mirror scanning module Including resonance galvanometer and galvanometer galvanometer, two-dimensional scan is realized by the cooperation of the resonance galvanometer and galvanometer galvanometer.
- 4. reflective confocal microscopic image system according to claim 1, it is characterised in that through the vibration mirror scanning mould The end face section of the incident fibre bundle for entering the fibre bundle module is in main image planes after block.
- 5. reflective confocal microscopic image system according to claim 1, it is characterised in that the detecting module is snow Collapse diode signal detector.
- 6. reflective confocal microscopic image system according to claim 5, it is characterised in that be also connected to including signal The analysis module of the avalanche diode signal sensor, the analysis module are used to obtain the avalanche diode signal detection The signal of device detection, and the signal is analyzed.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201621360140.0U CN206687691U (en) | 2016-12-12 | 2016-12-12 | A kind of reflective confocal microscopic image system |
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| CN201621360140.0U CN206687691U (en) | 2016-12-12 | 2016-12-12 | A kind of reflective confocal microscopic image system |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108209860A (en) * | 2016-12-12 | 2018-06-29 | 中国科学院苏州生物医学工程技术研究所 | A kind of reflective confocal microscopic image system |
| CN109407294A (en) * | 2018-12-07 | 2019-03-01 | 哈尔滨工业大学 | A kind of optical fiber fluorescence confocal microscopic imaging device and method |
-
2016
- 2016-12-12 CN CN201621360140.0U patent/CN206687691U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108209860A (en) * | 2016-12-12 | 2018-06-29 | 中国科学院苏州生物医学工程技术研究所 | A kind of reflective confocal microscopic image system |
| CN109407294A (en) * | 2018-12-07 | 2019-03-01 | 哈尔滨工业大学 | A kind of optical fiber fluorescence confocal microscopic imaging device and method |
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