CN206535011U - Neutron capture treatment system - Google Patents
Neutron capture treatment system Download PDFInfo
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- CN206535011U CN206535011U CN201621154870.5U CN201621154870U CN206535011U CN 206535011 U CN206535011 U CN 206535011U CN 201621154870 U CN201621154870 U CN 201621154870U CN 206535011 U CN206535011 U CN 206535011U
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Abstract
In order to obtain the neutron beam of multiple kinds of energy scope in neutron capture therapeutic process to meet the neutron beam power spectrum of the needs during actual therapeutic, the utility model provides a kind of neutron capture treatment system, including the accelerator for producing charged particle beam, the neutron generating unit of neutron beam is produced after charged particle beam irradiation, beam-shaping body and collimater, the beam-shaping body includes slow body and is coated on the reflector in slow external week, the neutron generating unit produces neutron after being irradiated through beam of charged ions, the slow body is by the neutron degradation produced from neutron generating unit to default power spectrum, the neutron that the reflector will deviate from leads back to improve the neutron intensity in default power spectrum, the neutron that the collimater produces neutron generating unit carries out cover, in neutron capture therapeutic process, the energy for the neutron beam that the neutron capture treatment system exposes to neutron generating unit and produced by changing the energy of charged particle beam to make changes.
Description
Technical field
The utility model is related to a kind of radioactive ray radiation treatment system, more particularly to a kind of neutron capture treatment system
System.
Background technology
With the development of atomics, the radiation cure such as cobalt 60, linear accelerator, electron beam turns into cancer
One of Main Means of disease treatment.But conventional photonic or electronic therapy are limited by radioactive ray physical condition itself, are being killed
While dead tumour cell, substantial amounts of normal structure in beam approach can also be damaged；Additionally, due to tumour cell to putting
The difference of radiation-sensitive degree, traditional radiation therapy is for relatively having the malignant tumour of radiation resistance（Such as：Multirow glioblast
Knurl（glioblastoma multiforme）, melanocytoma（melanoma））Treatment effect it is often not good.
In order to reduce the radiation injury of tumour surrounding normal tissue, chemotherapy（chemotherapy）In target therapy
Concept is just applied in radiation cure；And for the tumour cell of radiation resistance, also actively development has high phase at present
To biological effect（relative biological effectiveness,RBE）Radiation source, such as proton therapeutic, heavy particle control
Treatment, neutron capture treatment etc..Wherein, neutron capture treatment is to combine above two concept, and such as boron neutron capture is treated, by
Boracic medicine gathers in the specificity of tumour cell, and coordinating accurately neutron beam regulation and control, there is provided more more preferable than conventional radiation
Treatment of cancer is selected.
Boron neutron capture is treated（Boron Neutron Capture Therapy,BNCT）It is to utilize boracic（10B）Medicine
There is the characteristic of high capture cross section to thermal neutron, by10B(n,α)7Li neutron captures and nuclear fission reaction are produced4He and7Li two
Individual heavy burden charged particle.Reference picture 1, it illustrates the schematic diagram of boron neutron capture reaction, the average energy of two charged particles is about
2.33MeV, with High Linear transfer (Linear Energy Transfer, LET), short range feature, the linear energy of α particles
Transfer and range are respectively 150keV/ μm, 8 μm, and7Li heavy burdens particle is then 175keV/ μm, 5 μm, and the integrated range of two particle is about
Equivalent to one cell size, therefore the radiation injury caused for organism can be confined to cell level, when the choosing of boracic medicine
It is gathered in tumour cell to selecting property, appropriate neutron of arranging in pairs or groups penetrates source, just can be before not normal tissue causes too major injury
Put, reach the local purpose for killing tumour cell.
Because the effect that boron neutron capture is treated depends on tumour cell position boracic drug concentration and hankers quantum count, therefore again
It is referred to as binary radioactive ray treatment of cancer（binary cancer therapy）；It follows that except the exploitation of boracic medicine,
Neutron penetrates source quality and occupies key player in the research that boron neutron capture is treated.
Utility model content
In order to obtain the neutron beam of multiple kinds of energy scope in neutron capture therapeutic process to meet in actual therapeutic mistake
The neutron beam power spectrum needed in journey, a kind of neutron capture treatment system of one side offer of the present utility model, including for
Produce the accelerator of charged particle beam, the neutron generating unit of generation neutron beam, beam-shaping body after charged particle beam irradiation
And collimater, the beam-shaping body is including slow body and is coated on slow external all reflectors, the neutron generating unit
Produce neutron after being irradiated through beam of charged ions, the slow body by the neutron degradation produced from neutron generating unit to default power spectrum,
The neutron that the reflector will deviate from is led back to improve the neutron intensity in default power spectrum, and the collimater produces neutron generating unit
Raw neutron carries out cover, in neutron capture therapeutic process, and the neutron capture treatment system is by changing band electrochondria
The energy of beamlet makes the energy for the neutron beam for exposing to neutron generating unit and producing change.The application is mainly by changing
The energy for becoming charged particle beam changes the energy of neutron beam indirectly, and then changes the depth dose point of neutron capture treatment system
Cloth.
Further, in the application, by the way that the microwave generator of different pulses can be produced to the ion gun in accelerator
Accelerated, so that the charged particle that accelerator produces different-energy is penetrated.The neutron capture treatment system is provided with can
The microwave generator of microwave is injected to accelerator, the accelerator changes the powered of output according to the microwave of the different frequency of injection
The energy of the particle beams, when the energy of the charged particle beam of generation is the first value, the charged particle reacts with neutron generating unit
The first neutron beam energy value is produced, when the energy of the charged particle beam of generation is second value, the charged particle and neutron
Generating unit reaction produces the second neutron beam energy value, wherein first value is less than second value, the first neutron beam energy is low
In the second neutron beam energy.
Further, the energy for the charged particle beam that the neutron capture treatment system is produced passes through accelerator end electric-field strength
The change of degree and change.In the application neutron capture treatment system, the charged particle and neutron generating unit occur nuclear reaction it
Preceding structure should be understood as accelerator end.
Further, vacuum tube or/and the neutron generating unit, which is externally provided with, can produce electric field and to being passed in vacuum tube
The charged particle accelerate (beamacceleration) for defeated charged particle beam/expose to before neutron generating unit or the electric field feeding mechanism of deceleration, it is described
Electric field feeding mechanism is to refer to produce electric field and by the electric field of generation in vacuum tube periphery or the periphery of neutron generating unit
The external device that charged particle before making to expose to neutron generating unit can speed up or slow down, such as powered electrode.
Further, the neutron capture treatment system also has and the energy of the charged particle beam can be adjusted
Beam power spectrum regulating part, when the beam power spectrum regulating part is located in vacuum tube and in front of the neutron generating unit
When, the charged particle beam irradiation to beam power spectrum regulating part expose to neutron generating unit again after energy adjustment and produce
Sub-beam.
Further, holding part is provided with the vacuum tube, the beam power spectrum regulating part is contained in the holding part simultaneously
And the drive mechanism that can move beam power spectrum regulating part is connected with, when driving mechanisms control beam power spectrum regulating part fortune
When moving to neutron generating unit, the charged particle is exposed to after beam power spectrum regulating part and exposed to again after progress energy adjustment
Neutron generating unit；When beam power spectrum regulating part is contained in holding part without positioned at neutron generating unit described in the driving mechanisms control
During front, the charged particle beam direct irradiation is in the neutron generating unit.As one kind preferably, the holding part is located at institute
The lower section of neutron generating unit is stated, when the driving mechanisms control beam power spectrum regulating part is moved upwards, the beam power spectrum is adjusted
Section part is moved in front of neutron generating unit, the charged particle expose to after beam power spectrum regulating part carry out after energy adjustment again according to
It is incident upon neutron generating unit；When beam power spectrum regulating part is moved downward described in the driving mechanisms control, the beam power spectrum is adjusted
Section part is contained in holding part, and the charged particle beam direct irradiation is in the neutron generating unit.
Further, the beam power spectrum regulating part has multiple, and the beam power spectrum regulating part of varying number is to band electrochondria
The energy adjustment effect of beamlet is different, and the drive mechanism can drive each beam power spectrum regulating part to move up and down respectively with right
The energy of charged particle beam is adjusted.Also, the neutron energy spectrum regulating part, which can be used, can produce the material system of neutron
Make, such as beryllium, lithium.
Further, each beam power spectrum regulating part uses different material manufactures, the beam power spectrum of different materials
Regulating part is different to the energy adjustment effect of charged particle beam.
Further, the neutron generating unit is connected to an electric supply installation, and the neutron is produced by the electric supply installation
Life portion is powered, and the beam power spectrum of the charged particle beam changes after charged particle exposes to the neutron generating unit of energization.
Compared with prior art, the application neutron capture treatment system is adjusted by the energy to charged particle beam,
Change the energy of the neutron beam produced indirectly, to meet difference of the difference to the energy of neutron beam under different treatments
It is required that, it is simple in construction, it is easy to accomplish.
Brief description of the drawings
Fig. 1 is boron neutron capture reaction schematic diagram；
Fig. 2 is the schematic diagram of the application neutron capture treatment system；
Fig. 3 is provided with the schematic diagram of the neutron capture treatment system of microwave generator；
Fig. 4 is provided with the schematic diagram that electric field provides the neutron capture treatment system of device；
Fig. 5 is provided with the schematic diagram of the neutron capture treatment system of beam power spectrum regulating part；
Fig. 6 is the schematic diagram being powered to the coating of neutron generating unit.
Embodiment
Neutron capture treatment gradually increases as a kind of application of means of effective treating cancer in recent years, wherein with boron
Neutron capture treatment is most commonly seen, and the neutron of supply boron neutron capture treatment can be supplied by nuclear reactor or accelerator.This Shen
Embodiment please is by taking the treatment of accelerator boron neutron capture as an example, and the basic module of accelerator boron neutron capture treatment generally includes to use
In to charged particle（Such as proton, deuteron）Accelerator, neutron generating unit, hot removal system and the beam-shaping accelerated
Body, wherein accelerate the effect of charged particle and neutron generating unit to produce neutron, according to required neutron yield rate and energy, available
Accelerate the characteristics such as charged particle energy and size of current, the materialization of neutron generating unit to select suitable nuclear reaction, often begged for
The nuclear reaction of opinion has7Li(p,n)7Be and9Be(p,n)9B, both reactions are all the endothermic reaction.The energy valve of two kinds of nuclear reactions
Value is respectively 1.881MeV and 2.055MeV, because the preferable neutron source that boron neutron capture is treated is the superthermal of keV energy grades
Neutron, if being only slightly taller than the proton bombardment lithium metal target of threshold values using energy in theory, can produce the neutron of relative low energy, no
Slow processing that must be too many just can be used for clinic, but lithium metal（Li）With beryllium metal（Be）The neutron generating unit of two kinds of materials with
The proton-effect section of threshold values energy is not high, to produce sufficiently large neutron flux, is generally drawn from the proton of higher-energy
Send out nuclear reaction.
No matter boron neutron capture treatment nuclear reaction of the neutron source from nuclear reactor or accelerator charged particle and target,
What is produced is all mixed radiation field, i.e., beam contains neutron, photon of the low energy to high energy；Caught for the boron neutron of deep tumor
Treatment is obtained, in addition to epithermal neutron, remaining radiation content is more, cause the ratio of the non-selective dosage deposition of normal structure
It is bigger, therefore these can cause the radiation of unnecessary dosage to try one's best reduction.Except air beam quality factor, in knowing more about
Rapid Dose Calculation is carried out using human body head tissue prosthese in the dosage distribution that son is caused in human body, embodiments herein, and
It is used as the design reference of neutron beam with prosthese beam quality factor, will be described in more detail below.
International Atomic Energy Agency（IAEA）For the neutron source of clinical boron neutron capture treatment, penetrated given five air
Beam quality factor advises that this five suggestions can be used for the quality of relatively different neutron sources, and is provided with producing way as selecting neutron
Reference frame when footpath, design beam-shaping body.This five suggestion difference are as follows：
Epithermal neutron beam flux Epithermal neutron flux>1x 109n/cm2s
Fast neutron pollution Fast neutron contamination<2x 10-13Gy-cm2/n
Photon contamination Photon contamination<2x 10-13Gy-cm2/n
Thermal and epithermal neutron flux ratio thermal to epithermal neutron flux ratio<0.05
Middle electron current and flux ratio epithermal neutron current to flux ratio>0.7
Note：Subzone is hankered less than 0.5eV, fast-neutron range is more than in epithermal neutron energy area between 0.5eV to 40keV
40keV。
1st, epithermal neutron beam flux：
Boracic drug concentration has together decided on the clinical treatment time in neutron beam flux and tumour.If tumour boracic medicine
The enough height of concentration, the requirement for neutron beam flux just can be reduced；If conversely, boracic drug concentration is low in tumour, needing high pass
Epithermal neutron is measured to give the dosage that tumour is enough.IAEA is per second every square centimeter for the requirement of epithermal neutron beam flux
Epithermal neutron number be more than 109, the neutron beam under this flux can substantially control treatment for current boracic medicine
Time, short treatment time in addition to advantageous to patient's positioning and comfort level, also can more effectively utilize boracic medicine in one hour
Thing is in the intra-tumor limited holdup time.
2nd, fast neutron pollutes：
Because fast neutron can cause unnecessary normal tissue dose, therefore it is regarded as pollution, this dosage size and neutron
Energy is proportionate, thus neutron beam design on should try one's best reduction fast neutron content.Fast neutron pollution definition is unit
The adjoint fast neutron dosage of epithermal neutron flux, the suggestion that IAEA pollutes to fast neutron is less than 2x 10-13Gy-cm2/n。
3rd, photon contamination（Gamma-ray contamination）：
Gamma-rays belongs to wears radiation by force, can non-selectively cause the organized dosage deposition of institute on course of the beam, therefore
Reduction gamma-rays content be also neutron beam design exclusive requirement, gamma-ray contamination define for unit epithermal neutron flux it is adjoint
Gamma-rays dosage, suggestions of the IAEA to gamma-ray contamination is less than 2x 10-13Gy-cm2/n。
4th, thermal and epithermal neutron flux ratio：
Because thermal neutron decay speed is fast, penetration capacity is poor, into human body after most of energy be deposited on skin histology, remove
It is swollen for deep layers such as brain tumors outside the neutron source that the Several Epidermal Tumors such as melanocytoma need to be treated as boron neutron capture with thermal neutron
Knurl should reduce thermal neutron content.IAEA is less than 0.05 to the suggestion of thermal and epithermal neutron flux ratio.
5th, middle electron current and flux ratio：
Middle electron current represents the directionality of beam with flux ratio, and ratio is bigger to represent that tropism is good before neutron beam, high
The neutron beam of preceding tropism can reduce because neutron dissipate caused by normal surrounding tissue dosage, also improve in addition can treat depth and
Put pose gesture elasticity.IAEA centerings electron current is more than 0.7 with flux ratio suggestion.
The dosage distribution in tissue is obtained using prosthese, according to the dose versus depth curve of normal structure and tumour, pushes away false
Body beam quality factor.Following three parameter can be used for carrying out the comparison that different neutron beams treat benefit.
1st, effective therapeutic depth：
Tumor dose is equal to the depth of normal structure maximum dose, the position after this depth, what tumour cell was obtained
Dosage is less than normal structure maximum dose, that is, loses the advantage of boron neutron capture.What this parameter represented neutron beam penetrates energy
Power, effective therapeutic depth is bigger to represent that medicable tumor depth is deeper, and unit is cm.
2nd, effective therapeutic depth close rate：
That is the tumor dose rate of effective therapeutic depth, also equal to the maximum dose rate of normal structure.Because normal structure is received
Accumulated dose can give the factor of tumour accumulated dose size for influence, therefore parameter influences the length for the treatment of time, and effectively treatment is deep
Irradiation time needed for tumour doses are given in the bigger expression of degree close rate is shorter, and unit is cGy/mA-min.
3rd, dose therapeutically effective ratio：
From brain surface to effective therapeutic depth, the mean dose ratio that tumour and normal structure are received is referred to as effective
Therapeutic dose ratio；The calculating of mean dose, can be obtained by dose versus depth curve integration.Dose therapeutically effective ratio is bigger, represents
The treatment benefit of the neutron beam is better.
In order that beam-shaping body has in design compares foundation, except in the air of five IAEA suggestions beam quality because
Also the following ginseng for being used to assess neutron beam dosage performance quality is utilized in three plain and above-mentioned parameters, the embodiment of the present application
Number：
1st, irradiation time≤30min（The proton current that accelerator is used is 10mA）
2nd, 30.0RBE-Gy can treat depth >=7cm
3rd, tumour maximum dose >=60.0RBE-Gy
4th, normal cerebral tissue's maximum dose≤12.5RBE-Gy
5th, skin maximum dose≤11.0RBE-Gy
Note：RBE（Relative Biological Effectiveness）For relative biological effect, due to photon, neutron
The biological effect that can cause is different, thus dosage item as above be respectively multiplied by the relative biological effect of different tissues in the hope of etc.
Imitate dosage.
In actual neutron capture therapeutic process, patient and tumor presence under different situations are generally required using difference
The neutron beam of energy is irradiated treatment, and the neutron beam of energy goes to be treated needed for how obtaining as the case may be
Just into the problem of needing to solve.The application is in order to provide the neutron beam of multiple kinds of energy, by exposing to neutron generating unit
The energy of charged particle beam before is changed, because the energy change of charged particle beam, and neutron beam is by powered
React generation after particle-irradiation to neutron generating unit, therefore the energy change of charged particle beam can directly affect neutron and penetrate
The energy of beam.Herein described neutron capture treatment system changes the energy of neutron beam by changing the energy of charged particle beam
Amount includes but is not limited in boron neutron capture therapeutic process, and the application neutron capture treatment system is introduced in detail below.
As shown in Fig. 2 the application provides a kind of neutron capture treatment system 100, the neutron capture treatment system 100 is wrapped
Include for produce charged particle beam P accelerator 200, through charged particle beam P irradiate after produce neutron beam neutron generating unit
10th, beam-shaping body 11 and collimater 12.The beam-shaping body 11 includes slow body 13 and is coated on the slow periphery of body 13
Reflector 14.The neutron generating unit 10 produces neutron beam N after being irradiated through charged particle beam P, the slow body 13 will be certainly
The neutron beam N that neutron generating unit 10 is produced is decelerated to default power spectrum, and the neutron that the reflector 14 will deviate from leads back to improve
Neutron intensity in default power spectrum, the neutron that the collimater 12 produces neutron generating unit 10 carries out cover.The band
The energy of charged particle can change, and the neutron capture treatment system 100 is changed indirectly by changing the energy of charged particle beam
The energy for the neutron beam that neutron generating unit is produced, because neutron beam N is produced by exposing to neutron by charged particle beam P
Produced behind portion 10, so the change meeting neutron beam N of charged particle beam P energy energy production influence.I.e. the application is led to
The energy variation for crossing charged particle beam P changes neutron beam N energy indirectly, and then enables the neutron capture treatment system
More preferable neutron depth-dose distribution is enough provided.
As the first embodiment, as shown in figure 3, the neutron capture treatment system 100 also includes being arranged on acceleration
The microwave generator 300 at device end.The microwave generator 300 can produce the microwave of different frequency, the basis of accelerator 200
The microwave of the different frequency of injection to the ion gun in accelerator accelerate the energy of the charged particle beam so as to change output.
When the frequency that microwave generator 300 is injected into accelerator 200 is higher, acceleration of the accelerator 200 to ion gun is got over
It hurry up, the charged particle beam P of generation energy is also higher, neutron generating unit 10 is produced after being irradiated through the charged particle beam P
Neutron beam N energy is also higher；When the frequency that microwave generator 300 is injected into accelerator 200 is relatively low, the acceleration
Acceleration of the device 200 to ion gun is just relatively slow, and the charged particle beam P of generation energy is just relatively low, is irradiated through the charged particle beam P
The energy for the neutron beam N that neutron generating unit 10 afterwards is produced is lower.When the energy of the charged particle beam of generation is relatively low（For
One value）When, the charged particle and the energy that neutron generating unit reacts the neutron beam produced are relatively low（The energy of first neutron beam
Value）；When the energy of the charged particle beam of generation is higher（For second value）When, the charged particle reacts with neutron generating unit to be produced
The energy of raw neutron beam is higher（The energy value of second neutron beam）, wherein first value is less than in second value, first
The energy value of sub-beam is less than the energy value of the second neutron beam.
As shown in figure 4, as second of embodiment, the application can also by change the electric-field intensity at accelerator end come
Change charged particle beam P energy.Because the electric-field intensity at accelerator end has very big shadow to charged particle beam P accelerating velocity
Ring, and during charged particle beam P accelerating velocity directly affects charged particle beam P energy, therefore charged particle beam P is exposed to
Sub- generating unit 10 and the neutron beam N energy that produces can be affected.
As an embodiment for changing accelerator end electric-field intensity, the application is outside vacuum tube 15 or in
Sub- generating unit 10 is outer to be set electric field feeding mechanism 16 to produce to exposing to the charged particle beam P before neutron generating unit 10 to enter
The electric field that row accelerates or slowed down.As one kind preferably, the electric field feeding mechanism 16 refers to powered electrode, logical by control
The voltage difference at electrode two ends is adjusted to the electric-field intensity difference of generation, so that charged particle beam P is accelerated or subtracted
Speed, does not just remake and illustrates herein.
In fact no matter outside vacuum tube 15 or in the such purpose of electric field feeding mechanism 16 of the outer setting of neutron generating unit 10
It is provided to carry out secondary adjustment to the energy of the charged particle beam P after the acceleration of accelerator 200, in favor of charged particle beam
P can produce the energy level neutron beam N for meeting needs in neutron capture therapeutic process when exposing to neutron generating unit 10.That is,
By controlling the electric field at accelerator end to change charged particle beam P energy, change neutron beam N energy indirectly.Certainly, also may be used
To set such electric field feeding mechanism 16 outside vacuum tube 15 and outside neutron generating unit 10 respectively, to charged particle beam P's
Energy is repeatedly adjusted, so as to be more easy to realize such energy adjusting, finally obtains the energy level that is needed in therapeutic process
Neutron beam N.
Fig. 5 is the third embodiment for the energy that the application changes charged particle beam P.In present embodiment, in vacuum
The beam power spectrum regulating part 17 for being located at the front of neutron generating unit 10 is set in pipe 15, and the charged particle beam P exposes to beam energy
Spectrum regulating part 17 carries out exposing to neutron generating unit 10 after energy adjustment again and then produces neutron beam N, finally realizes to neutron
Beam N energy adjustment.
The beam power spectrum regulating part 17 is in vacuum tube 15 and positioned at the lower section of neutron generating unit 10, the vacuum tube 15
Interior to be provided with the holding part 151 for being located at the lower section of neutron generating unit 10, the beam power spectrum regulating part 17 is contained in the holding part 151
In.Because the beam power spectrum regulating part 17 of varying number can be different to the Adjustment effect of charged particle beam P energy, because
This, sets multiple beam power spectrum regulating parts 17 in vacuum tube 15, and each beam power spectrum regulating part 17 is connected to drive
Motivation structure 18, the drive mechanism 18 controls each beam power spectrum regulating part 17 upwardly or downwardly to move respectively, i.e., described to drive
Motivation structure 18 can be that one or more beam power spectrum regulating part 17 is upwardly or downwardly moved simultaneously.Caught in actual neutron
Obtain in therapeutic process, drive mechanism 18 is worked according to the energy requirement to neutron beam N, each penetrate is controlled by drive mechanism 18
The motion conditions of Shu Nengpu regulating parts 17.It is described when the drive mechanism 18 control beam power spectrum 17 motion upwards of regulating part
Beam power spectrum regulating part 17 moves to the front of neutron generating unit 10, and the charged particle beam P exposes to the beam power spectrum regulation
Part 17 exposes to neutron generating unit 10 again after carrying out energy adjustment；When beam power spectrum regulating part 17 described in the driving mechanisms control
When moving downward, the beam power spectrum regulating part 17 is contained in holding part 151, and the charged particle beam P direct irradiations are in described
Neutron generating unit 10.Charged particle beam P energy is adjusted by beam power spectrum regulating part 17, so that Indirect method neutron
Beam N power spectrum.In addition, the beam power spectrum regulating part is in addition to located at the lower section of neutron generating unit, it can also be arranged on true
Other positions in blank pipe, as long as can be located at when needing the energy to charged particle beam to be adjusted before neutron generating unit
Side, is not located in front of neutron generating unit when the energy of charged particle beam need not be adjusted.
For the ease of the manufacture and installation of beam power spectrum regulating part 17, each beam power spectrum regulating part 17 is designed to
Identical structure and each beam power spectrum regulating part 17 is ordered in holding part 15, the He of beam power spectrum regulating part 17
The section vertical with charged particle beam P direction of illumination of neutron generating unit 10 is rounded, the beam power spectrum regulating part 17
Radius is less than the radius of the neutron generating unit 10.In order to alleviate beam power spectrum regulating part 17 after being irradiated through charged particle beam P
Heat condition, beam power spectrum regulating part 17 periphery set cooling device（It is not shown）, the beam power spectrum regulating part 17
The setting of cooling device may be referred to the type of cooling in the prior art to neutron generating unit 10, it is just no longer specific herein to be situated between
Continue.When charged particle beam P exposes to beam power spectrum regulating part 17, the beam power spectrum regulating part 17 is to charged particle beam P's
Energy is adjusted, and the cooling device is cooled down to beam power spectrum regulating part 17.
The thickness of each beam power spectrum regulating part 17 can be the same or different, in addition, the beam power spectrum is adjusted
The material of section part 17 can be the same or different.When the beam power spectrum regulating part 17 uses identical material manufacture,
Can be by the beam of driving mechanisms control varying number to the different requirements of neutron beam N energy in neutron capture therapeutic process
Power spectrum regulating part 17 moves downwardly to the front of neutron generating unit 10 to realize；When the beam power spectrum regulating part 17 is using different
When material is made, the different of neutron beam N energy are required both pass through driving mechanisms control in neutron capture therapeutic process
The beam power spectrum regulating part 17 of varying number moves downward realization, can also be by the beam energies of driving mechanisms control different materials
Spectrum regulating part 17 moves downward realization.In addition, the beam power spectrum regulating part 17, which can also be used, can produce neutron beam N's
Material is made, such as lithium or beryllium.It is pointed out that neutron beam N material manufacture beam power spectrum can be produced when using
During regulating part 17, the beam power spectrum regulating part 17 should be set close proximity to neutron generating unit 10, such that powered
Particle beams P, which exposes to the neutron beam that the neutron beam produced during beam power spectrum regulating part 17 produces with neutron generating unit, to be had
Effect is utilized.Certainly, if beam power spectrum regulating part 17 is made of the material for not producing neutron beam, as long as beam power spectrum is adjusted
Part 17 is located in vacuum tube 15 and can move downward and be located at the front of neutron generating unit 10 under the control of drive mechanism,
Energy adjustment is carried out to the charged particle beam P for exposing to neutron generating unit 10.
With reference to Fig. 6, as the 4th kind of embodiment, the neutron generating unit 10 of the neutron capture treatment system 100 is connected
In a power device 20.Being powered by 20 pairs of the electric supply installation neutron generating unit 10 causes the inside of neutron generating unit to produce
Raw electric field, the beam power spectrum of the charged particle beam P occurs because charged particle beam P is exposed to after the neutron generating unit 10 after being powered
Change.
Certainly, in order to obtain more preferable neutron beam N qualities, microwave generator, electric field supply dress can also be set simultaneously
Put, beam power spectrum regulating part and the neutron generating unit for being connected to power device, with this to being produced in neutron capture therapeutic process
Charged particle beam P carry out multiple energy adjustment so that be easier obtain need energy level neutron beam, herein just not
Illustrate again.
The beam-shaping body treated for neutron capture that the application is disclosed is not limited to interior described in above example
Structure represented by appearance and accompanying drawing.Done on the basis of the application to the material of wherein component, shape and position aobvious and
Easy insight changes, substitutes or changed, all this application claims within the scope of.
Claims (10)
1. a kind of neutron capture treatment system, it is characterised in that：Including the accelerator for producing charged particle beam, through band electrochondria
The neutron generating unit of neutron beam is produced after beamlet irradiation, is produced for the charged particle after the acceleration of accelerated device to be transmitted to neutron
Vacuum tube, beam-shaping body and the collimater in life portion, the beam-shaping body include slow body and are coated on slow external week
Reflector, the slow body by the neutron degradation produced from neutron generating unit to default power spectrum, what the reflector will deviate from
Neutron is led back to improve the neutron intensity in default power spectrum, and the collimater is concentrated the neutron that neutron generating unit is produced,
The neutron that the neutron capture treatment system exposes to neutron generating unit and produced by changing the energy of charged particle beam to make is penetrated
The energy of beam changes.
2. neutron capture treatment system according to claim 1, it is characterised in that：The neutron capture treatment system is provided with
The microwave generator of microwave can be injected to accelerator, the accelerator changes output according to the microwave of the different frequency of injection
The energy of charged particle beam, when the energy of the charged particle beam of generation is the first value, the charged particle and neutron generating unit
Reaction produce the first neutron beam energy value, when generation charged particle beam energy be second value when, the charged particle with
The reaction of neutron generating unit produces the second neutron beam energy value, wherein first value is less than second value, the first neutron beam energy
Value is less than the second neutron beam energy value.
3. neutron capture treatment system according to claim 1, it is characterised in that：The neutron capture treatment system is produced
The energy of charged particle beam changed by the change of accelerator end electric-field intensity.
4. neutron capture treatment system according to claim 3, it is characterised in that：The vacuum tube or/and neutron are produced
Portion be externally provided with can produce electric field and by the electric field of generation make charged particle beam expose to the preacceleration of neutron generating unit or
The electric field feeding mechanism that person is slowed down.
5. neutron capture treatment system according to claim 1, it is characterised in that：The neutron capture treatment system also has
There is the beam power spectrum regulating part that the energy of the charged particle beam can be adjusted, when the beam power spectrum regulating part is located at
In vacuum tube and when being located in front of the neutron generating unit, the charged particle beam irradiation to beam power spectrum regulating part carries out energy
Neutron generating unit is exposed to again and neutron beam is produced after amount regulation.
6. neutron capture treatment system according to claim 5, it is characterised in that：Holding part is provided with the vacuum tube,
The beam power spectrum regulating part is contained in the holding part and is connected with the driving machine that can move beam power spectrum regulating part
Structure, when the driving mechanisms control beam power spectrum regulating part is moved in front of neutron generating unit, the charged particle is exposed to
Neutron generating unit is exposed to again after carrying out energy adjustment after beam power spectrum regulating part；When beam energy described in the driving mechanisms control
When spectrum regulating part is contained in holding part without in front of neutron generating unit, the charged particle beam direct irradiation is in the neutron
Generating unit.
7. neutron capture treatment system according to claim 6, it is characterised in that：The beam power spectrum regulating part has many
Individual, the beam power spectrum regulating part of varying number acts on different to the energy adjustment of charged particle beam, and the drive mechanism driving is every
Individual beam power spectrum regulating part is moved respectively to be adjusted with the energy to charged particle beam.
8. neutron capture treatment system according to claim 6, it is characterised in that：Each beam power spectrum regulating part is adopted
With different material manufactures, the beam power spectrum regulating part of different materials is different to the energy adjustment effect of charged particle beam.
9. neutron capture treatment system according to claim 1, it is characterised in that：The neutron generating unit is connected to a confession
Electric installation, is powered by the electric supply installation to the neutron generating unit, and the beam power spectrum of the charged particle beam is in band electrochondria
Son changes after exposing to the neutron generating unit of energization.
10. neutron capture treatment system according to claim 1, it is characterised in that：The neutron capture treatment system is led to
The beam power spectrum for crossing change charged particle beam changes the power spectrum of neutron beam indirectly, and then changes in neutron capture treatment system
Sub- depth-dose distribution.
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| CN201621154870.5U CN206535011U (en) | 2016-10-31 | 2016-10-31 | Neutron capture treatment system |
| EP17864029.8A EP3517172B1 (en) | 2016-10-31 | 2017-07-13 | Neutron capture therapy system |
| JP2019541838A JP6831921B2 (en) | 2016-10-31 | 2017-07-13 | Neutron capture therapy system |
| PCT/CN2017/092702 WO2018076790A1 (en) | 2016-10-31 | 2017-07-13 | Neutron capture therapy system |
| TW106128748A TWI632932B (en) | 2016-10-31 | 2017-08-24 | Neutron capture therapy system |
| US16/373,775 US10773104B2 (en) | 2016-10-31 | 2019-04-03 | Neutron capture therapy system |
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