CN207856088U - Beam-shaping body for neutron capture treatment - Google Patents
Beam-shaping body for neutron capture treatment Download PDFInfo
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- CN207856088U CN207856088U CN201720641461.6U CN201720641461U CN207856088U CN 207856088 U CN207856088 U CN 207856088U CN 201720641461 U CN201720641461 U CN 201720641461U CN 207856088 U CN207856088 U CN 207856088U
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Abstract
A kind of beam-shaping body that can change neutron beam range of exposures for neutron capture system is provided,Including beam entrance,Target,It is adjacent to the slow body of the target,It is enclosed in slow external reflector,With the thermal neutron absorber of slow body adjoining,Radiation shield in beam-shaping body and beam outlet are set,With the proton beam from beam entrance incidence nuclear reaction occurs for target to generate neutron,Neutron forms neutron beam,Neutron beam limits a main shaft,Slow body will be from the neutron degradation that the target generates to epithermal neutron energy area,The neutron that reflector will deviate from main shaft leads back to the main shaft to achieve the effect that converge epithermal neutron,When thermal neutron absorber is for absorbing thermal neutron to avoid treatment multi-dose was caused with shallow-layer normal structure,Radiation shield is used to shield the neutron leaked and photon to reduce the normal tissue dose in non-irradiated area,Beam-shaping body further includes that can be assembled and disassembled from beam-shaping body to change the refill-unit of neutron beam range of exposures.
Description
Technical field
The utility model is related to a kind of beam-shaping body more particularly to a kind of beam-shapings for neutron capture treatment
Body.
Background technology
As the radiation cures such as the development of atomics, such as cobalt 60, linear accelerator, electron beam have become cancer
One of the main means of disease treatment.However conventional photonic or electronic therapy are limited by radioactive ray physical condition itself, are being killed
While dead tumour cell, a large amount of normal structure in beam approach can also be damaged；Additionally, due to tumour cell to putting
The difference of radiation-sensitive degree, traditional radiation therapy is for relatively having the malignant tumour of radiation resistance (such as：Multirow glioblast
Tumor (glioblastoma multiforme), melanocytoma (melanoma)) treatment effect it is often bad.
In order to reduce the radiation injury of tumour surrounding normal tissue, the target therapy in chemotherapy (chemotherapy)
Concept is just applied in radiation cure；And for the tumour cell of radiation resistance, also actively development has high phase at present
To the radiation source of biological effect (relative biological effectiveness, RBE), as proton therapeutic, heavy particle are controlled
Treatment, neutron capture treatment etc..Wherein, neutron capture treatment is to combine above two concept, if boron neutron capture is treated, by
Boracic drug gathers in the specificity of tumour cell, and accurately neutron beam regulates and controls for cooperation, provides more better than conventional radiation
Treatment of cancer selects.
Boron neutron capture treatment (Boron Neutron Capture Therapy, BNCT) be using boracic (10B) drug
The characteristic to thermal neutron with high capture cross section, by10B(n,α)7Li neutron captures and nuclear fission reaction generate4He and7Li two
A heavy burden charged particle.Referring to Figures 1 and 2, which respectively show boron neutron capture reaction schematic diagram and10B(n,α)7Li neutrons
Nuclear equation formula is captured, the average energy of two charged particles is about 2.33MeV, and there is High Linear to shift (Linear Energy
Transfer, LET), short range feature, the linear energy transfers of α particles and range are respectively 150keV/ μm, 8 μm, and7Li weights
Lotus particle is then 175keV/ μm, 5 μm, and the integrated range of two particle is approximately equivalent to a cell size, therefore organism is caused
Radiation injury can be confined to cell level, be gathered in tumour cell when boracic drug selectivity, neutron appropriate of arranging in pairs or groups
Source is penetrated, just can achieve the purpose that tumour cell is killed in part under the premise of normal tissue does not cause too major injury.
Because the effect of boron neutron capture treatment depends on tumour cell position boracic drug concentration and thermal neutron quantity, therefore again
It is referred to as binary radioactive ray treatment of cancer (binary cancer therapy)；Beam is whole used in existing AB-BNCT facilities
Body adopts the size that neutron beam is adjusted with the collimator of diversified different pore size more, however, the case where not loading collimator
Under, beam outlet is then made of reflector and neutron shield, is limited to beam outlet so only relying on collimator, beam
The variable range of outlet is just restricted.For example, the beam exit radius of the beam-shaping body of collimator ought not added to be 7 public
Point, and when tumor region is larger, it can not can completely irradiate tumour affected part because beam exposure range is smaller；When not plus collimator
The beam exit radius of beam-shaping body be 10 centimeters, and when tumor region is smaller, even if plus set collimator, collimator is limited
In its thickness, as beam exposure range is too big, beam exposure area can not be effectively limited, normal surrounding tissue is caused
By meaningless irradiation.
Utility model content
In order to provide a kind of beam-shaping body that can change neutron beam range of exposures, the one side of the utility model
A kind of beam-shaping body for neutron capture treatment is provided, the beam-shaping body includes beam entrance, target, is adjacent to institute
It states the slow body of target, be enclosed in the slow external reflector, the thermal neutron absorber abutted with the slow body, setting
Radiation shield in the beam-shaping body and beam outlet, the target and the proton beam from the beam entrance incidence
Nuclear reaction occurs to generate neutron, the neutron forms neutron beam, and the neutron beam limits a main shaft, the slow body
By from the neutron degradation that the target generates to epithermal neutron energy area, the neutron that the reflector will deviate from the main shaft leads back to institute
Main shaft is stated to converge epithermal neutron, the thermal neutron absorber for absorb thermal neutron to avoid when treatment with shallow-layer normal structure
Multi-dose, the radiation shield was caused to be used to shield the neutron leaked and photon to reduce the normal structure agent in non-irradiated area
Amount, the beam-shaping body further include be installed in the beam-shaping body and can be dismantled from the beam-shaping body with
Change the alternative of neutron beam range of exposures, the alternative forms the beam outlet.
Further, the alternative includes the first refill-unit and the second refill-unit, and first refill-unit includes remote
The second end with second diameter of the first end and the close target with first diameter from the target, described second
Refill-unit includes the with the 4th diameter of third end far from the target with third diameter and the close target
Four ends, the first end of first refill-unit form the beam with the first bore and export, the third end of second refill-unit
It forms the beam with the second bore to export, first bore is not equal to the second bore.
Preferably as one kind, first refill-unit has the main part of connection first end and second end, the main body
The outer surface in portion is parallel with the main shaft, it can be understood as the profile of the main part is bar shape.
Preferably as one kind, first refill-unit has the main part of connection first end and second end, the main body
It is gradually smaller cone-shaped that the outer surface in portion is formed slopely diameter from first end to second end, it can be understood as the refill-unit
Main part is cone-shaped, and the inner surface of the main part is formed slopely the gradually smaller cone of diameter from second end to first end
Shape.
As other embodiment, first refill-unit has the main part of connection first end and second end, the main body
The outer surface in portion is formed slopely that diameter is gradually smaller cone-shaped from second end to first end, the inner surface of the main part also from
It is gradually smaller cone-shaped that second end to first end is formed slopely diameter.In this embodiment, since the second diameter of second end is big
In the first diameter of first end, cause the first integrally formed refill-unit that can not be mounted directly in beam-shaping body.It therefore can
To be arranged to multiple sub- refill-units along the circumferential direction separated, by installing sub- refill-unit one by one to form complete first
Refill-unit.
Further, the first end, which is equipped with, is through to the through-hole of second end, described in the through-hole is formed in first end
Beam exports, and the neutron beam goes out from the beam exit radiation.
Further, there is the beam-shaping body inner surface, the radiation shield to have end, and described first replaces
There is part the main part of connection first end and second end, first refill-unit to be installed on the beam-shaping body from the end
In, the outer surface of the main part is contacted with the inner surface of the beam-shaping body, the first end flushed with the end or
The end is protruded from along the direction far from the target.
Further, first refill-unit along proton beam incident direction set on the front side of slow body and with the end
It flushes or protrudes from the end along the direction far from the target, first refill-unit is partial reflector and/or part
Radiation shield.
Further, the slow body includes two cone portions to adjoin each other, and one of cone portion leans on close-range shot
Beam entrance, another cone portion are exported close to beam, and first refill-unit is adjacent to what slow body was exported close to the beam
On rear side of cone portion.
Further, it is described reflection be made of any one or more in Pb or Ni, the radiation shield include by
Photon shielding and the neutron shield made of polyethylene made of Pb.
Further, the beam-shaping body is further used for the treatment of accelerator boron neutron capture, and accelerator boron neutron is caught
Treatment is obtained by accelerator by proton accelerate (beamacceleration), the target is made of metal, and the proton beam, which accelerates to, to be enough to overcome target
With the target nuclear reaction occurs for the energy of atomic nucleus coulomb repulsion to generate neutron.The beam-shaping physical efficiency delays neutron
Speed reduces thermal neutron and fast neutron content to epithermal neutron energy area, and epithermal neutron energy area hankers between 0.5eV to 40keV
Subzone is less than 0.5eV, and fast-neutron range is more than 40keV.
" bar shape " described in the embodiment of the present application refers to the side along diagram direction to its outer profile of the other side
A wherein contour line for the structure that overall trend is basically unchanged, outer profile can be line segment, such as the corresponding wheel of cylindrical shape
Profile can also be the larger circular arc close to line segment of curvature, such as the corresponding contour line of the larger sphere body shape of curvature, foreign steamer
Wide whole surface can be rounding off, can also be non-rounding off, ball such as larger in cylindrical shape or curvature
Many protrusions and groove are done in the surface of face body shape.
" cone-shaped " described in the embodiment of the present application refers to the side along diagram direction to its outer profile of the other side
A wherein contour line for the gradually smaller structure of overall trend, outer profile can be line segment, such as the corresponding wheel of cone shape
Profile can also be circular arc, if the whole surface of the corresponding contour line of sphere body shape, outer profile can be rounding off,
It can also be non-rounding off, such as done many protrusions and groove on the surface of cone shape or sphere body shape.
Description of the drawings
Fig. 1 is boron neutron capture reaction schematic diagram.
Fig. 2 is10B(n,α)7Li neutron capture nuclear equation formulas.
Fig. 3 is the floor map for the beam-shaping body that the application does not install alternative.
Fig. 4 is the section plan for the beam-shaping body for being mounted with the first refill-unit.
Fig. 5, which is the first refill-unit, will be installed on beam-shaping body, and the second refill-unit is not installed on beam-shaping body
In schematic diagram.
Fig. 6 a are the schematic diagrames of the first refill-unit another kind embodiment shown in Fig. 5.
Fig. 6 b are the signal parts of the second refill-unit another kind embodiment shown in Fig. 5, wherein the bore of the second refill-unit is less than
The bore of beam outlet, and the main part of refill-unit is cone portion.
Specific implementation mode
Neutron capture treatment is gradually increased as a kind of application of means of effective treating cancer in recent years, wherein with boron
Neutron capture treatment is most commonly seen, and the neutron of supply boron neutron capture treatment can be supplied by nuclear reactor or accelerator.This Shen
By taking the treatment of accelerator boron neutron capture as an example, the basic module of accelerator boron neutron capture treatment generally includes to use embodiment please
In the accelerator, target and hot removal system and beam-shaping body that are accelerated to charged particle (such as proton, deuteron), wherein
Accelerate charged particle to generate neutron with metal targets effect, is charged according to required neutron yield rate and energy, available acceleration
The characteristics such as the materialization of particle energy and size of current, metal targets select suitable nuclear reaction, the nuclear reaction being often discussed
Have7Li(p,n)7Be and9Be(p,n)9B, both reactions are all the endothermic reaction.The energy threshold of two kinds of nuclear reactions is respectively
1.881MeV and 2.055MeV, it is theoretical due to the epithermal neutron that the ideal neutron source of boron neutron capture treatment is keV energy grades
If the upper proton bombardment lithium metal target for being only slightly taller than threshold values using energy can generate the neutron of opposite low energy, be not necessary to too many
Slow processing can be used for clinic, however two kinds of targets of lithium metal (Li) and beryllium metal (Be) and the proton-effect of threshold values energy are cut
Face is not high, for the neutron flux for generating sufficiently large, the proton of higher-energy is usually selected to cause nuclear reaction.
Ideal target should have high neutron yield rate, the neutron energy of generation is distributed (will be under close to epithermal neutron energy area
Text detailed description), without wear by force too much radiation generate, the characteristics such as cheap easily operated and high temperature resistant of safety, but actually and can not
It finds and meets required nuclear reaction, using target made of lithium metal in embodiments herein.But art technology
Known to personnel, the material of target can also be made of other metal materials other than the above-mentioned metal material talked about.
Requirement for hot removal system is then different according to the nuclear reaction of selection, such as7Li(p,n)7Be is because of metal targets (lithium
Metal) fusing point and thermal conductivity coefficient it is poor, requirement to hot removal system just compared with9Be(p,n)9B high.It is adopted in embodiments herein
With7Li(p,n)7The nuclear reaction of Be.
No matter boron neutron capture treatment nuclear reaction of the neutron source from nuclear reactor or accelerator charged particle and target,
What is generated is all mixed radiation field, i.e., beam contains neutron, photon of the low energy to high energy；The boron neutron of deep tumor is caught
Treatment is obtained, other than epithermal neutron, remaining radiation content is more, causes the ratio of the non-selective dosage deposition of normal structure
It is bigger, therefore these can cause the radiation of unnecessary dosage that should reduce as possible.In addition to air beam quality factor, in knowing more about
Son in human body caused by dosage be distributed, carry out Rapid Dose Calculation using human body head tissue prosthese in embodiments herein, and
It is used as the design reference of neutron beam with prosthese beam quality factor, will be described in more detail below.
International Atomic Energy Agency (IAEA) is directed to the neutron source of clinical boron neutron capture treatment, is penetrated given five air
Beam quality factor suggestion, this five suggestions can be used for the quality of the different neutron sources of comparison, and be provided with as select neutron generate way
Reference frame when diameter, design beam-shaping body.This five suggestion difference are as follows：
Epithermal neutron beam flux Epithermal neutron flux>1x 109n/cm2s
Fast neutron pollutes Fast neutron contamination<2x 10-13Gy-cm2/n
Photon contamination Photon contamination<2x 10-13Gy-cm2/n
Thermal and epithermal neutron flux ratio thermal to epithermal neutron flux ratio<0.05
Middle electron current and flux ratio epithermal neutron current to flux ratio>0.7
Note：Hanker subzone between 0.5eV to 40keV and be less than 0.5eV, fast-neutron range is more than in epithermal neutron energy area
40keV。
1, epithermal neutron beam flux：
Boracic drug concentration has codetermined the clinical treatment time in neutron beam flux and tumour.If tumour boracic drug
The enough height of concentration, the requirement for neutron beam flux can reduce；Conversely, if boracic drug concentration is low in tumour, high pass is needed
Epithermal neutron is measured to give tumour enough dosage.Requirements of the IAEA for epithermal neutron beam flux is per second every square centimeter
Epithermal neutron number be more than 109, the neutron beam under this flux can substantially control treatment for current boracic drug
Time, short treatment time other than advantageous to patient's positioning and comfort level, also can relatively efficiently use boracic medicine in one hour
Object limited residence time within the tumor.
2, fast neutron pollutes：
Since fast neutron can cause unnecessary normal tissue dose, it is regarded as pollution, this dosage size and neutron
Energy is proportionate, therefore should reduce the content of fast neutron to the greatest extent in neutron beam design.Fast neutron pollution definition is unit
The adjoint fast neutron dosage of epithermal neutron flux, IAEA are less than 2x 10 to the suggestion that fast neutron pollutes-13Gy-cm2/n。
3, photon contamination (gamma-ray contamination)：
Gamma-rays belongs to wears radiation by force, can non-selectively cause the organized dosage deposition of institute on course of the beam, therefore
Reduce gamma-rays content be also neutron beam design exclusive requirement, gamma-ray contamination define for unit epithermal neutron flux it is adjoint
Gamma-rays dosage, IAEA are less than 2x 10 to the suggestion of gamma-ray contamination-13Gy-cm2/n。
4, thermal and epithermal neutron flux ratio：
Since thermal neutron decay speed is fast, penetration capacity is poor, into human body after most of energy be deposited on skin histology, remove
The Several Epidermal Tumors such as melanocytoma need to be used outside the neutron source that thermal neutron is treated as boron neutron capture, swollen for deep layers such as brain tumors
Tumor should reduce thermal neutron content.IAEA is less than 0.05 to thermal and epithermal neutron flux ratio suggestion.
5, middle electron current and flux ratio：
Middle electron current represents the directionality of beam with flux ratio, and tropism is good before the bigger expression neutron beam of ratio, high
The neutron beam of preceding tropism can reduce because neutron dissipate caused by normal surrounding tissue dosage, in addition also improve can treat depth and
Put pose gesture elasticity.IAEA centerings electron current is more than 0.7 with flux ratio suggestion.
The dosage in tissue is obtained using prosthese to be distributed, and according to the dose versus depth curve of normal structure and tumour, pushes away false
Body beam quality factor.Following three parameter can be used for carrying out the comparison of different neutron beam treatment benefits.
1, effective therapeutic depth：
Tumor dose is equal to the depth of normal structure maximum dose, the position after this depth, what tumour cell obtained
Dosage is less than normal structure maximum dose, that is, loses the advantage of boron neutron capture.What this parameter represented neutron beam penetrates energy
Power, effective therapeutic depth is bigger to indicate that medicable tumor depth is deeper, unit cm.
2, effective therapeutic depth dosage rate：
That is the tumor dose rate of effective therapeutic depth is also equal to the maximum dose rate of normal structure.Because normal structure receives
Accumulated dose is the factor for influencing to give tumour accumulated dose size, therefore parameter influences the length for the treatment of time, and effectively treatment is deep
Degree dosage rate is bigger, and the irradiation time for indicating to give needed for tumour doses is shorter, unit cGy/mA-min.
3, dose therapeutically effective ratio：
From brain surface to effective therapeutic depth, the mean dose ratio that tumour and normal structure receive, referred to as effectively
Therapeutic dose ratio；The calculating of mean dose can be integrated to obtain by dose versus depth curve.Dose therapeutically effective ratio is bigger, represents
The treatment benefit of the neutron beam is better.
Compare foundation to make beam-shaping body have in design, in addition to five IAEA suggest air in beam quality because
Three plain and above-mentioned parameters also utilize the following ginseng good and bad for assessing the performance of neutron beam dosage in the embodiment of the present application
Number：
1, irradiation time≤30min (proton current that accelerator uses is 10mA)
2,30.0RBE-Gy can treat depth >=7cm
3, tumour maximum dose >=60.0RBE-Gy
4, normal cerebral tissue's maximum dose≤12.5RBE-Gy
5, skin maximum dose≤11.0RBE-Gy
Note：RBE (Relative Biological Effectiveness) is relative biological effect, due to photon, neutron
Caused by meeting
Biological effect is different, thus dosage item as above be respectively multiplied by the relative biological effect of different tissues in the hope of etc.
Imitate dosage.
In actual neutron capture therapeutic process, the range of exposures of neutron beam be also take in it is important because
Element.Embodiments herein is the improvement proposed for the beam-shaping body for neutron capture treatment, preferably as one kind,
It is the improvement for the beam-shaping body for the treatment of accelerator boron neutron capture.
As shown in figure 3, the application be used for neutron capture treatment beam-shaping body 10, including beam entrance 11, target 12,
The slow body 13 for being adjacent to target 12, the reflector 14 being enclosed in outside slow body 13, the neutron absorption abutted with slow body 13
Body 15, the radiation shield 16 being arranged in beam-shaping body 10 and beam outlet 17, target 12 with it is incident from beam entrance 11
Proton beam nuclear reaction occurs to generate neutron, neutron forms neutron beam, and neutron beam limits a major axis X, slow body 13
By from the neutron degradation that target 12 generates to epithermal neutron energy area, the neutron that reflector 14 will deviate from major axis X leads back to major axis X to converge
Clearance channel 18 is arranged to improve epithermal neutron flux, neutron absorption in poly- epithermal neutron between slow body 13 and reflector 14
Body 15 caused multi-dose to avoid when treatment for absorbing thermal neutron with shallow-layer normal structure, and radiation shield 16 is for shielding
The neutron and photon of leakage are to reduce the normal tissue dose in non-irradiated area.
In boron neutron capture therapeutic process, in order to reach preferable therapeutic effect, while reducing and health tissues are caused
Damage, it is necessary to different neutron beam ranges of exposures is provided for different size of tumour, it is therefore desirable to provide a kind of energy
Enough adjust the beam-shaping body 10 of neutron beam range of exposures.In the application, realized to neutron by the way that alternative 20 is arranged
The adjustment of beam exposure range.The beam-shaping body 10 further includes alternative 20, the alternative 20 include size not
Same the first refill-unit 21 and the second refill-unit 22.First refill-unit, 21 and second refill-unit 22 is able to be installed on institute
It states in beam-shaping body 10, and can be removed from beam-shaping body 10 mutually to replace.
The treatment of accelerator boron neutron capture passes through accelerator by proton accelerate (beamacceleration), as a kind of preferred embodiment, target 12
It is made of lithium metal, proton beam accelerates to the energy for being enough to overcome target atom core coulomb repulsion, occurs with target 127Li(p,
n)7Be nuclear reactions are to generate neutron (in conjunction with shown in Fig. 1 and Fig. 2).Shown beam-shaping body 10 is by neutron slowly to epithermal neutron
Energy area, and thermal neutron and fast neutron content are reduced, slow body 13 is by big, the epithermal neutron action section with fast neutron action section
Small material is made, and as a kind of preferred embodiment, slow body 13 is by D2O、AlF3、FluentalTM、CaF2、Li2CO3、MgF2With
Al2O3In any one or more be made.Reflector 14 with the strong material of neutron reflection ability by being made, as a kind of excellent
Embodiment, reflector 14 is selected to be made of any one or more in Pb or Ni.Thermal neutron absorber 15 with thermal neutron by acting on
The big material in section is made, as a kind of preferred embodiment, thermal neutron absorber 15 by6Li is made, 15 He of thermal neutron absorber
Air duct 19 is equipped between beam outlet 17, the sustainable neutron that will deviate from major axis X of setting of air duct 19 leads back to major axis X
To achieve the effect that converge epithermal neutron.Radiation shield 16 includes photon shield 161 and Neutron shielding body 162, as one
Kind of preferred embodiment, radiation shield 16 include the photon shield 161 made of lead (Pb) and made of polyethylene (PE)
Neutron shielding body 162.
The slow body 13 is arranged to the cone portion that two opposite directions adjoin each other, direction as shown in Figure 3, slow body
13 left side is towards the gradually smaller cone portion 131 in left side, and the right side of slow body 13 is towards the gradually smaller cone in right side
Portion 132, the two adjoins each other, and the cone portion 131 in 13 left side of the slow body is the cone portion close to beam entrance 11, described slow
The cone portion 132 on 13 right side of fast body is the cone portion of beam outlet 17.Reflector 14 is closely enclosed in around slow body 13,
Slow that clearance channel 18 is provided between body 13 and reflector 14, so-called clearance channel 18 refers to unused solid material covering
It is empty it is easy allow neutron beam by region, as the clearance channel 18 could be provided as air duct or vacuum passage.Tightly
The thermal neutron absorber 15 that adjacent slow body 13 is arranged is by very thin one layer6Li materials are made, in radiation shield 16 by Pb systems
At photon shield 161 can be arranged with reflector 14 and be integrated, can also be arranged to fission, and in radiation shield 16 by
Neutron shielding body 162 made of PE can be positioned adjacent to the position of beam outlet 17.It is well known to those skilled in the art, photon
Shield 161 can be made of other materials, as long as playing the role of shielding photon, Neutron shielding body 162 can also be by
Other materials is made, as long as disclosure satisfy that the condition of shielding leakage neutron.
In conjunction with Fig. 4 and Fig. 5, radiation shield 16 has closest illuminated positioned at 10 outermost of beam-shaping body
The end 163 of body, the beam-shaping body 10 have inner surface 101, and first refill-unit 21 is from the end of radiation shield 16
Portion 163 is installed on forward the cone in the beam-shaping body 10 and positioned at slow body 13 close to the end of radiation shield 16 163
The rear side (that is, first refill-unit 21 is set to the front side of slow body 13 along the incident direction of proton beam) in body portion 132, described the
The outer surface 26 of one refill-unit 21 is contacted with the inner surface 101 of the beam-shaping body 10.For the ease of by the first refill-unit 21
It is installed in beam-shaping body 10, and the first refill-unit 21 can be dismantled from the beam-shaping body 10 to be replaced with second
It changes part 22 to be replaced, the structure of the first refill-unit 21 is designed as follows.
First refill-unit 21 has first end 23, second end 24 and the main body for connecting first end 23 and second end 24
The inner surface 211 in portion 25, first refill-unit 21 is formed slopely the gradually smaller cone of diameter from second end 24 to first end 23
Body shape.The first end 23 flushes far from the target 12 and with the end of the radiation shield 16 163 or along far from institute
The direction for stating target 12 protrudes from the end 163.The second end 24 is close to target 12, and the diameter D1 of the first end 23 is not
Less than the diameter D2 of second end 24.Preferably as one kind, the outer surface 26 of the main part 25 is limited with the neutron beam
Major axis X it is parallel, that is, the profile of 25 outer surface 26 of the main part be bar shape.The first end 23 is equipped with is through to forward
The through-hole 27 of second end 24, the through-hole 27 form the beam with the first bore d1 in first end 23 and export.As another
Kind embodiment, the outer surface of the main part 25 ' can also be arranged to be formed slopely directly from first end 23 ' to second end 24 '
Diameter is gradually smaller cone-shaped, and in conjunction with Fig. 6 a, the diameter D1 ' of first end 23 ' is more than the diameter D2 ' of second end 24 ', and described first
The first end 23 ' of refill-unit 21 ' forms the beam with the first bore d1 ' and exports.
There is second refill-unit 22 third end 28 and the 4th end 29, the diameter D3 at the third end 28 to be not less than the 4th end 29
Diameter D4.The third end 28 is equipped with forward the through-hole 30 for being through to the 4th end 29, the shape on third end 28 of the through-hole 30
At the beam outlet with the second bore d2.In order to ensure the interchangeability of the second refill-unit 22 and the first refill-unit 21, together
When achieve the effect that adjust neutron beam range of exposures, as it is a kind of preferably, to the structure of the second refill-unit 22 with reference to first
The structure design of refill-unit 21, and make the size of the first bore d1 and the second bore d2 inconsistent.Fig. 6 b show second and replace
Change outer surface gradually smaller cone-shaped, the third that is arranged to be formed slopely diameter from first end 28 ' to second end 29 ' of part 22 '
The diameter D3 ' at end 28 ' is more than the diameter D4 ' of second end 29 ', and the third end 28 ' of second refill-unit 22 ', which is formed, has second
The beam of bore d2 ' exports.
It illustrates, it is assumed that is installed in beam-shaping body 10 is the first refill-unit 21, the through-hole 27 of the first refill-unit 21
The the first bore d1 formed in first end 23 is smaller, and in practical irradiation process, neutron beam need the range irradiated compared with
When big, the first refill-unit 21 is removed from beam-shaping body 10, the second bore d2 formed on third end 23 is larger
The second refill-unit 22, likewise, the first bore that is formed in first end 23 of through-hole 27 of the first refill-unit 21 when installation
D1 is larger, and in practical irradiation process, it is when neutron beam needs the range irradiated smaller, the first refill-unit 21 is whole from beam
Removed in body 10, the second smaller the second bore d2 formed on third end 23 refill-unit 22, the first refill-unit and
The structure snd size of second refill-unit can also there are many kinds of, according to neutron beam need range of exposures specific requirements select penetrate
Beam exports suitable first refill-unit of bore or the second refill-unit.
The alternative 20 can will deviate from major axis X neutron lead back to major axis X with achieve the effect that converge epithermal neutron,
Meanwhile it can also shield the neutron or/and photon of leakage.It is preferably carried out mode as one kind, in the application, the replacement dress
20 are set as a part for the reflector 14 and radiation shield 16, it can be understood as, the alternative 20 is by part
The monolithic construction that reflector 14 and partial radiation shield 16 are manufactured into installs the first refill-unit 21 in alternative 20
Neutron beam is converged in beam-shaping body 10, and according to actual demand by the first refill-unit 21 from the beam
In shaping body 10 dismantle be replaced with beam outlet suitable second refill-unit 22 of bore with the range of exposures to neutron beam into
Row adjustment.Certainly, it is partial reflector 14 and/or partial radiation shield 16 that the alternative 20, which does not limit to, yet, can be with
Including the slow body 13 in part and/or thermal neutron absorber 15 and partial reflector 14 and/or partial radiation shield 16, even
May include part collimator (not shown), when the first end of first refill-unit is protruded along the direction far from the target 12
When the end 163, first refill-unit 21 includes part collimator, can be right as long as the setting of alternative 20
The bore of beam outlet is adjusted to change the range of exposures of neutron beam, and thermal neutron is converged in varying degrees to reach
Effect.
In the application, the alternative 20 can only include a refill-unit, as do not installed the first refill-unit in Fig. 5
When, a kind of bigbore beam outlet can be also formed, after installing the first refill-unit, is then formed a kind of relatively small-bore
Beam exports；The alternative 20 can also include the first refill-unit 21 and the second refill-unit 22 or more refill-units,
To realize the beam outlet of different size bore.
" bar shape " described in the embodiment of the present application refers to the side along diagram direction to its outer profile of the other side
A wherein contour line for the structure that overall trend is basically unchanged, outer profile can be line segment, such as the corresponding wheel of cylindrical shape
Profile can also be the larger circular arc close to line segment of curvature, such as the corresponding contour line of the larger sphere body shape of curvature, foreign steamer
Wide whole surface can be rounding off, can also be non-rounding off, ball such as larger in cylindrical shape or curvature
Many protrusions and groove are done in the surface of face body shape.
" cone-shaped " described in the embodiment of the present application refers to the side along diagram direction to its outer profile of the other side
A wherein contour line for the gradually smaller structure of overall trend, outer profile can be line segment, such as the corresponding wheel of cone shape
Profile can also be circular arc, if the whole surface of the corresponding contour line of sphere body shape, outer profile can be rounding off,
It can also be non-rounding off, such as done many protrusions and groove on the surface of cone shape or sphere body shape.
The beam-shaping body for neutron capture treatment that the application discloses is not limited to interior described in above example
Structure represented by appearance and attached drawing.Done aobvious of material and shape and position on the basis of the application to wherein component and
Easy insight changes, substitutes or modification, all this application claims within the scope of.
Claims (10)
1. a kind of beam-shaping body for neutron capture treatment, it is characterised in that：The beam-shaping body include beam entrance,
Target, the slow body for being adjacent to the target are enclosed in the slow external reflector, hanker with what the slow body abutted
Sub- absorber, the radiation shield being arranged in the beam-shaping body and beam outlet, the target enter with from the beam
Nuclear reaction occurs for the incident proton beam of mouth to generate neutron, and the neutron forms neutron beam, and the neutron beam limits one
Main shaft, by from the neutron degradation that the target generates to epithermal neutron energy area, the reflector will deviate from described the slow body
The neutron of main shaft leads back to the main shaft to converge epithermal neutron, and the thermal neutron absorber is for absorbing thermal neutron to avoid treatment
When with shallow-layer normal structure caused multi-dose, the radiation shield is used to shield the neutron leaked and photon to reduce non-photograph
The normal tissue dose in area is penetrated, the beam-shaping body further includes being installed in the beam-shaping body and capable of being penetrated from described
It is dismantled in beam shaping body to change the alternative of neutron beam range of exposures, the alternative forms the beam outlet.
2. the beam-shaping body according to claim 1 for neutron capture treatment, it is characterised in that：The alternative
Including the first refill-unit and the second refill-unit, first refill-unit includes first with first diameter far from the target
End and the second end with second diameter close to the target, second refill-unit include far from the target with the
The 4th end with the 4th diameter at the third end of three diameters and the close target, the first end of first refill-unit are formed
Beam outlet with the first bore, the third end of second refill-unit forms the beam with the second bore and exports, described
First bore is not equal to the second bore.
3. the beam-shaping body according to claim 2 for neutron capture treatment, it is characterised in that：Described first replaces
Part has the main part of connection first end and second end, the outer surface of the main part parallel with the main shaft.
4. the beam-shaping body according to claim 2 for neutron capture treatment, it is characterised in that：Described first replaces
Part has the main part of connection first end and second end, and the outer surface of the main part is formed slopely directly from first end to second end
Diameter is gradually smaller cone-shaped, and the inner surface of the main part is formed slopely the gradually smaller cone of diameter from second end to first end
Body shape.
5. the beam-shaping body according to claim 2 for neutron capture treatment, it is characterised in that：The first end is set
There are the through-hole for being through to second end, the through-hole to form the beam outlet in first end, the neutron beam is penetrated described in
Beam exit radiation goes out.
6. the beam-shaping body according to claim 2 for neutron capture treatment, it is characterised in that：The beam-shaping
There is body inner surface, the radiation shield there is end, first refill-unit to have the master of connection first end and second end
Body portion, first refill-unit are installed on from the end in the beam-shaping body, the outer surface of the main part with it is described
The inner surface of beam-shaping body contacts, and the first end flushes with the end or protrudes from institute along the direction far from the target
State end.
7. the beam-shaping body according to claim 6 for neutron capture treatment, it is characterised in that：Described first replaces
Part is flushed with the end set on the front side of slow body along the incident direction of proton beam or is dashed forward along the direction far from the target
For the end, first refill-unit is partial reflector and/or partial radiation shield.
8. the beam-shaping body according to claim 7 for neutron capture treatment, it is characterised in that：The slow body packet
The cone portion to adjoin each other containing two, one of cone portion go out close to beam entrance, another cone portion close to beam
Mouthful, first refill-unit is adjacent to slow body on rear side of the cone portion that the beam exports.
9. the beam-shaping body according to claim 1 for neutron capture treatment, it is characterised in that：The reflector by
Any one or more in Pb or Ni is made, and the radiation shield includes that the photon made of Pb shields and by polyethylene system
At neutron shield.
10. the beam-shaping body according to claim 1 for neutron capture treatment, it is characterised in that：The beam is whole
Body is further used for the treatment of accelerator boron neutron capture, and the treatment of accelerator boron neutron capture is added proton beam by accelerator
Speed, the target are made of metal, and the proton beam accelerates to the energy for being enough to overcome target atom core coulomb repulsion, and described
Nuclear reaction occurs for target to generate neutron, and neutron slowly to epithermal neutron energy area, and is reduced and hankered by the beam-shaping physical efficiency
Son and fast neutron content, epithermal neutron energy area hanker subzone and are less than 0.5eV, fast-neutron range between 0.5eV to 40keV
More than 40keV.
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720641461.6U CN207856088U (en) | 2017-06-05 | 2017-06-05 | Beam-shaping body for neutron capture treatment |
| PCT/CN2017/092725 WO2018223487A1 (en) | 2017-06-05 | 2017-07-13 | Beam shaping assembly for neutron capture therapy |
| JP2019572273A JP2020509919A (en) | 2017-06-05 | 2017-07-13 | Beam shaping body for neutron capture therapy |
| EP17912898.8A EP3566748B1 (en) | 2017-06-05 | 2017-07-13 | Beam shaping assembly for neutron capture therapy |
| RU2019129988A RU2734955C1 (en) | 2017-06-05 | 2017-07-13 | Beam forming unit for neutron capturing therapy |
| TW106128760A TWI642410B (en) | 2017-06-05 | 2017-08-24 | Beam shaping body for neutron capture therapy |
| US16/511,142 US11559705B2 (en) | 2017-06-05 | 2019-07-15 | Neutron capture therapy system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720641461.6U CN207856088U (en) | 2017-06-05 | 2017-06-05 | Beam-shaping body for neutron capture treatment |
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| Publication Number | Publication Date |
|---|---|
| CN207856088U true CN207856088U (en) | 2018-09-14 |
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ID=63473757
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720641461.6U Active CN207856088U (en) | 2017-06-05 | 2017-06-05 | Beam-shaping body for neutron capture treatment |
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| Country | Link |
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| CN (1) | CN207856088U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108969899A (en) * | 2017-06-05 | 2018-12-11 | 南京中硼联康医疗科技有限公司 | Beam-shaping body for neutron capture treatment |
-
2017
- 2017-06-05 CN CN201720641461.6U patent/CN207856088U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108969899A (en) * | 2017-06-05 | 2018-12-11 | 南京中硼联康医疗科技有限公司 | Beam-shaping body for neutron capture treatment |
| CN108969899B (en) * | 2017-06-05 | 2024-07-12 | 南京中硼联康医疗科技有限公司 | Beam shaping body for neutron capture therapy |
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