CN107569779A - Neutron therapy device - Google Patents
Neutron therapy device Download PDFInfo
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- CN107569779A CN107569779A CN201610517978.4A CN201610517978A CN107569779A CN 107569779 A CN107569779 A CN 107569779A CN 201610517978 A CN201610517978 A CN 201610517978A CN 107569779 A CN107569779 A CN 107569779A
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- tube bank
- therapy device
- shaping body
- supporting part
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- 238000009203 neutron therapy Methods 0.000 title claims abstract description 46
- 238000007493 shaping process Methods 0.000 claims abstract description 83
- 238000010884 ion-beam technique Methods 0.000 claims abstract description 20
- 238000001228 spectrum Methods 0.000 claims abstract description 6
- 230000015556 catabolic process Effects 0.000 claims abstract description 3
- 238000006731 degradation reaction Methods 0.000 claims abstract description 3
- 230000004308 accommodation Effects 0.000 claims description 15
- 230000005540 biological transmission Effects 0.000 claims description 9
- 230000008859 change Effects 0.000 claims description 8
- 230000001678 irradiating effect Effects 0.000 claims description 7
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 230000000452 restraining effect Effects 0.000 claims description 2
- 230000003760 hair shine Effects 0.000 claims 1
- 238000010276 construction Methods 0.000 abstract description 2
- 230000004907 flux Effects 0.000 description 19
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 13
- 229910052796 boron Inorganic materials 0.000 description 13
- 238000010586 diagram Methods 0.000 description 12
- 230000033001 locomotion Effects 0.000 description 11
- 238000006243 chemical reaction Methods 0.000 description 9
- 239000002245 particle Substances 0.000 description 9
- 206010028980 Neoplasm Diseases 0.000 description 8
- 230000005855 radiation Effects 0.000 description 8
- 238000011109 contamination Methods 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 238000013461 design Methods 0.000 description 6
- 230000004888 barrier function Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 3
- 230000005251 gamma ray Effects 0.000 description 3
- 238000005286 illumination Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000000717 retained effect Effects 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 229910052744 lithium Inorganic materials 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000010415 tropism Effects 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- CVOFKRWYWCSDMA-UHFFFAOYSA-N 2-chloro-n-(2,6-diethylphenyl)-n-(methoxymethyl)acetamide;2,6-dinitro-n,n-dipropyl-4-(trifluoromethyl)aniline Chemical compound CCC1=CC=CC(CC)=C1N(COC)C(=O)CCl.CCCN(CCC)C1=C([N+]([O-])=O)C=C(C(F)(F)F)C=C1[N+]([O-])=O CVOFKRWYWCSDMA-UHFFFAOYSA-N 0.000 description 1
- 208000003174 Brain Neoplasms Diseases 0.000 description 1
- 208000019155 Radiation injury Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- ATBAMAFKBVZNFJ-UHFFFAOYSA-N beryllium atom Chemical compound [Be] ATBAMAFKBVZNFJ-UHFFFAOYSA-N 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
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- Radiation-Therapy Devices (AREA)
Abstract
The invention discloses a kind of neutron therapy device, including beam-shaping body, neutron generating unit in beam-shaping body, ion beam is sent to the tube bank of neutron generating unit, so that deflection electromagnet and collimater that direction of beam transport changes, the beam-shaping body includes slow body and is packaged in the reflector in slow external week, the neutron generating unit produces neutron after ion beam irradiation, the slow body will be from neutron degradation caused by neutron generating unit to default power spectrum, the neutron that the reflector will deviate from is led back to improve the neutron intensity in default power spectrum, the tube bank has axis, the beam-shaping body can rotate around the axis of tube bank and the irradiation of different angle is carried out to irradiated body.Whole neutron therapy device is only rotated self structure by the setting of support frame, beam-shaping body and deflection magnet just can realize that whole neutron therapy device carries out the irradiation of different angle, and simple in construction, operating is light, it is easy to accomplish.
Description
Technical field
The present invention relates to a kind of radioactive ray irradiation unit, especially a kind of neutron therapy device.
Background technology
The neutron therapy device used in boron neutron capture therapeutic system is usually because need multiple to irradiated body progress
The irradiation of angle, and in the past in order to realize that neutron therapy device is generally fixed on some huge structure by the irradiation of this multi-angle
Rotating device on, the rotation for passing through rotating device drives the rotation of neutron therapy device.It will be apparent that neutron therapy device sheet
The structure of body is just very huge, to drive the rotation of neutron therapy device to need to compare neutron by the rotating device in the external world
The huger rotating device of therapeutic system could be realized, and meet the rotation of neutron therapy device and rotating device simultaneously
Very big space is also needed to, not only heavy but also applicability is not strong for whole device, is unfavorable for the miniaturization of neutron therapy device
Design.
The content of the invention
In order to provide a kind of neutron therapy device that can carry out multi-angle neutron ray irradiation, one aspect of the present invention
A kind of neutron therapy device is provided, the neutron therapy device includes beam-shaping body, the neutron production in beam-shaping body
Life portion, the tube bank that ion beam is sent to neutron generating unit, so that the deflection electromagnet that changes of direction of beam transport with
And collimater, the beam-shaping body include slow body and are packaged in the reflector in slow external week, the neutron generating unit warp
Neutron is produced after ion beam irradiation, the slow body will be described anti-from neutron degradation caused by neutron generating unit to default power spectrum
The neutron that beam will deviate from is led back to improve the neutron intensity in default power spectrum, and the collimater is by caused by neutron generating unit
Son carries out cover, and the neutron therapy device has the irradiation space being irradiated to irradiated body, and the tube bank has
Axis, the beam-shaping body can be rotated around the axis of tube bank so as to carry out different angle to the irradiated body in irradiation space
Irradiation.
Further, the neutron therapy device also includes support frame, and the beam-shaping body is immobilizated in support frame, beam
Also moved while shaping body is around tube bank axis rotation on support frame.
Further, the tube bank includes the first tube bank and the 3rd tube bank being connected with the first tube bank, and the axis includes
The first axle of first tube bank and the second axis of the 3rd tube bank, the beam-shaping body can be around the first axles of the first tube bank
Or the 3rd tube bank second axis rotate.
Further, the first angle, the size energy of first angle are formed between first tube bank and the 3rd tube bank
Enough position relationships changed to adjust beam-shaping body with irradiate irradiated body in space.
Further, support frame as described above includes the first supporting part, and irradiation is spatially located at below the first supporting part, and described first
Supporting part is provided with the first track, and the beam-shaping body is immobilizated in the first track of support frame, and first track is recessed in branch
For support so as to form the accommodation space being connected with irradiating space, the collimater extends into irradiation space from accommodation space.
Further, first supporting part is set for arc-shaped, and first track is and the same circle of the first supporting part
The arc-shaped of the heart is set, the recessed formation of arc-shaped surface of the first track from first supporting part.
Further, the tube bank also includes the second tube bank, and second tube bank is connected to neutron generating unit, and described second
The second angle is formed between tube bank and the 3rd tube bank, second angle is sized to change to adjust beam-shaping body with shining
Penetrate the position relationship of irradiated body in space.
Further, the deflection magnet is immobilizated in support frame, and the deflection magnet is included positioned at the first tube bank and the 3rd
The first deflection magnet between tube bank and the second deflection magnet between the second tube bank and the 3rd tube bank, first pipe
The transmission direction of beam intermediate ion beam is transmitted after being changed by the first deflection magnet into the 3rd tube bank, the 3rd tube bank intermediate ion
The transmission direction of beam is transmitted after being changed by the second deflection magnet to the second tube bank, and the ion beam irradiation in the second tube bank is extremely
Neutron generating unit, produce the neutron beam being irradiated for neutron ray device.
Further, support frame as described above be additionally provided with for support the second deflection magnet the second supporting part, described second
Support part is provided with the second track, and when beam-shaping body moves in the first track, second supporting part is transported in the second track
It is dynamic.
Further, support frame as described above is additionally provided with the 3rd supporting part, and first deflection magnet is immobilizated in the 3rd supporting part,
First tube bank is fixed between accelerator and the first deflection magnet, and second tube bank is connected to beam-shaping body and second
Between deflection magnet, the 3rd tube bank is connected between the first deflection magnet and the second deflection magnet.
Compared with prior art, the application has the advantages that：The application by support frame, beam-shaping body and
The setting of deflection magnet, which makes whole neutron therapy device only to rotate self structure, just can realize that whole neutron therapy device is carried out
The irradiation of different angle, simple in construction, operating is light, it is easy to accomplish.
Brief description of the drawings
Fig. 1 is the schematic diagram that the present invention is not provided with support frame；
Fig. 2 is the sectional view of neutron generating unit of the present invention；
Fig. 3 is that the present invention sets the schematic diagram after support frame；
Fig. 4 is the schematic diagram that beam-shaping body of the embodiment of the present invention is immobilizated in the first track；
Fig. 5 is the top view that beam-shaping body is retained in the track of supporting part first；
Fig. 6 is the schematic diagram of another angle of the invention；
Fig. 7 is schematic diagram when the first angle a1 of the present invention changes；
Fig. 8 is schematic diagram when the second angle a2 of the present invention changes
Fig. 9 is the another embodiment schematic diagram of support frame of the present invention；
Figure 10 is the sectional view of shield in one embodiment of the present invention；
Figure 11 is the state diagram of shielding part when beam-shaping body of the present invention moves to a certain position in the first track；
Figure 12 is the state diagram of shielding part when beam-shaping body of the present invention moves to another location in the first track；
Figure 13 is top view when showing shield stretching, extension described in Fig. 8；
Figure 14 is the sectional view of shield in another embodiment of the present invention；
Figure 15 is the state diagram of shield when beam-shaping body moves to a certain position shown in Figure 14；
Figure 16 is the top view of shield shown in Figure 10.
Embodiment
The present invention is described in further detail below in conjunction with the accompanying drawings, to make those skilled in the art with reference to specification text
Word can be implemented according to this.
A kind of application of the neutron exposure as means of effective treating cancer in recent years gradually increases, wherein with boron neutron
Capture treatment is most commonly seen, and the neutron of supply boron neutron capture treatment can be supplied by nuclear reactor or accelerator.The application's
Embodiment by accelerator boron neutron capture treatment exemplified by, accelerator boron neutron capture treatment basic module generally include be used for pair
Accelerator, neutron generating unit and hot removal system and the beam-shaping body that charged particle (such as proton, deuteron) is accelerated,
Wherein accelerate the effect of charged particle and metal neutron generating unit to produce neutron, according to required neutron yield rate and energy, can provide
Acceleration charged particle energy and size of current, the characteristic such as materialization of metal neutron generating unit select suitable nuclear reaction,
The nuclear reaction often to come into question has 7Li (p, n) 7Be and 9Be (p, n) 9B, and both reactions are all the endothermic reaction.Two kinds of nuclear reactions
Energy threshold is respectively 1.881MeV and 2.055MeV, because the preferable neutron source of boron neutron capture treatment is keV energy grades
Epithermal neutron, if being only slightly taller than the proton bombardment lithium metal neutron generating unit of threshold values using energy in theory, can produce relative
The neutron of low energy, clinic can be used for by being not necessary to too many slow processing, but two kinds of neutrons of lithium metal (Li) and beryllium metal (Be)
Generating unit and the proton-effect section of threshold values energy be not high, to produce sufficiently large neutron flux, generally from higher-energy
Proton triggers nuclear reaction.
Boron neutron capture treatment (Boron Neutron Capture Therapy, BNCT) is to utilize boracic (10B) medicine
There is the characteristic of high capture cross section to thermal neutron, 4He and 7Li is produced by 10B (n, α) 7Li neutron captures and nuclear fission reaction
Two heavy burden charged particle.Referring to Figures 1 and 2, which respectively show in the schematic diagram and 10B (n, α) 7Li of boron neutron capture reaction
Son capture nuclear equation formula, the average energy of two charged particles is about 2.33MeV, has High Linear transfer (Linear
Energy Transfer, LET), short range feature, the linear energy transfers of α particles and range are respectively 150keV/ μm, 8 μm,
And 7Li heavy burdens particle is then 175keV/ μm, 5 μm, the integrated range of two particle is approximately equivalent to a cell size, therefore for life
Radiation injury caused by object can be confined to cell level, be gathered in when boracic drug selectivity in tumour cell, and collocation is suitable
When neutron penetrate source, just can reach the local mesh for killing tumour cell on the premise of not normal tissue causes too major injury
's.
No matter boron neutron capture treatment nuclear reaction of the neutron source from nuclear reactor or accelerator charged particle and target,
Caused is all mixed radiation field, i.e., beam contains neutron, photon of the low energy to high energy；Caught for the boron neutron of deep tumor
Treatment is obtained, in addition to epithermal neutron, remaining radiation content is more, causes the ratio of the non-selective dosage deposition of normal structure
It is bigger, therefore these can cause the radiation of unnecessary dosage to try one's best reduction.Except air beam quality factor, in knowing more about
Son dosage caused by human body is distributed, and Rapid Dose Calculation is carried out using head mathematics prosthese model in embodiments of the invention, and
It is used as the design reference of neutron beam with prosthese beam quality factor, will be described in more detail below.
International Atomic Energy Agency (IAEA) is directed to the neutron source of clinical boron neutron capture treatment, is penetrated given five air
Beam quality factor suggestion, this five suggestions can be used for more different neutron sources quality, and be provided with as select neutron produce way
Reference frame when footpath, design beam-shaping body.This five suggestion difference are as follows：
Epithermal neutron beam flux Epithermal neutron flux>1x 109n/cm2s
Fast neutron pollution Fast neutron contamination<2x 10-13Gy-cm2/n
Photon contamination Photon contamination<2x 10-13Gy-cm2/n
Thermal and epithermal neutron flux ratio thermal to epithermal neutron flux ratio<0.05
Middle electron current and flux ratio epithermal neutron current to flux ratio>0.7
Note：Hanker subzone between 0.5eV to 40keV and be less than 0.5eV, fast-neutron range is more than in epithermal neutron energy area
40keV。
Epithermal neutron beam flux：
Boracic drug concentration has together decided on the clinical treatment time in neutron beam flux and tumour.If tumour boracic medicine
The enough height of concentration, the requirement for neutron beam flux can reduce；Conversely, if boracic drug concentration is low in tumour, high pass is needed
Epithermal neutron is measured to give tumour enough dosage.Requirements of the IAEA for epithermal neutron beam flux is per second every square centimeter
Epithermal neutron number be more than 109, the neutron beam under this flux can substantially control treatment for current boracic medicine
Time, short treatment time in addition to advantageous to patient's positioning and comfort level, also can more effectively utilize boracic medicine in one hour
Thing is in the intra-tumor limited holdup time.
Fast neutron pollutes：
Because fast neutron can cause unnecessary normal tissue dose, therefore it is regarded as pollution, this dosage size and neutron
Energy is proportionate, therefore should be tried one's best in neutron beam design and reduce the content of fast neutron.Fast neutron pollution definition is unit
The adjoint fast neutron dosage of epithermal neutron flux, the suggestion that IAEA pollutes to fast neutron are less than 2x 10-13Gy-cm2/n.
Photon contamination (gamma-ray contamination)：
Gamma-rays belongs to wears radiation by force, can non-selectively cause the organized dosage deposition of institute on course of the beam, therefore
Reduce gamma-rays content be also neutron beam design exclusive requirement, gamma-ray contamination define for unit epithermal neutron flux it is adjoint
Gamma-rays dosage, suggestions of the IAEA to gamma-ray contamination are less than 2x 10-13Gy-cm2/n.
Thermal and epithermal neutron flux ratio：
Because thermal neutron decay speed is fast, penetration capacity is poor, into human body after most of energy be deposited on skin histology, remove
Outside the neutron source that the Several Epidermal Tumors such as melanocytoma need to treat by the use of thermal neutron as boron neutron capture, swollen for deep layers such as brain tumors
Knurl should reduce thermal neutron content.IAEA is less than 0.05 to the suggestion of thermal and epithermal neutron flux ratio.
Neutron streaming and flux ratio：
Neutron streaming represents the directionality of beam with flux ratio, and tropism is good before the bigger expression neutron beam of ratio, high
The neutron beam of preceding tropism can reduce because neutron dissipate caused by normal surrounding tissue dosage, also improve in addition can treat depth and
Put pose gesture elasticity.IAEA is more than 0.7 to neutron streaming and flux ratio suggestion.
Fig. 1 is the application neutron therapy device 100, and the neutron therapy device 100 includes beam-shaping body 10, located at penetrating
Neutron generating unit 11 in beam shaping body 10, ion beam P transmitted to the tube bank 20 of neutron generating unit 11 from accelerator 200 and
The deflection magnet 30 for making the intermediate ion beam P of tube bank 20 transmission direction change.The beam-shaping body 10 includes slow body 12
And slow external 12 weeks reflector 13 is packaged in, the neutron generating unit 11 is embedded in the slow body 12 (with reference to Fig. 2).
The beam-shaping body 10 exports with beam, and end face A where the beam outlet is provided with collimater 40.
With reference to Fig. 3, the neutron therapy device 100 also includes being used for the irradiation space 50 for being irradiated irradiated body M
With the support frame 60 for supporting beam-shaping body 10.Support frame as described above 60 includes the first supporting part 61, first supporting part
The first track 611 is provided with 61, the track of the first supporting part 61 and first is arranged to the same center of circle for the ease of manufacture
Convex structure.In other embodiments, the first supporting part 61 and the first track 611 can be arranged to other shapes,
More changed with the position to the relative exposure space 50 of beam-shaping body 10, just do not illustrated herein.The beam
Shaping body 10 is immobilizated in the first track 611 and can moved in the first track 611, so that neutron therapy device is to irradiation
Irradiated body M in space 50 carries out the irradiation of different angle.
With reference to Fig. 4 to Fig. 6, as a kind of embodiment, first track 611 is arranged on to the circular arc of the first supporting part 61
Outer surface.The irradiation space 50 is located at the lower section of the first supporting part 61, circle of first track 611 from the first supporting part 61
The accommodation space 612 that the recessed formation in arc outer surface is connected with irradiation space 50.The outer surface of the reflector 13 is extended with position
Holding parts 131 in the both sides of beam-shaping body 10, the holding parts 131 are immobilizated in first track 611 and along the first rails
Road 611 is moved, and the collimater 40 is extended in irradiation space 50 from accommodation space 612.Certainly, in order to which whole neutron therapy fills
The Miniaturization Design put, holding parts can not be set on the surface of reflector, and make end face A of the beam-shaping body provided with collimater
Coordinate with the first track 611, the end face A is directly retained on the first track 611 and by end face A in the first track 611
Motion makes irradiation of the neutron therapy device 100 to irradiated body M progress different angles.
As another embodiment, the irradiation space 50 can be not arranged in the lower section of the first supporting part 61, and position
In the side of the first supporting part 61, holding parts extend from beam-shaping body 10 and are located at the side of beam-shaping body 10, described
Holding parts are retained in the first track 611 and moved in the first track 611.The now beam outlet direction of beam-shaping body 10
Space 50 ' is irradiated, when beam-shaping body 10 moves in the first track 611, neutron therapy device 100 can be to irradiating space
The irradiated body irradiation (not shown) for carrying out different angle in 50 '.
First track can also be arranged on the front end face of first supporting part.Outside the reflexive beam of holding parts
Extend and be immobilizated in the first track and transported in the first track positioned at the side of beam-shaping body, the holding parts in surface
It is dynamic.Certainly, also a lot of other embodiments, are such as not provided with holding parts and partial reflector directly are immobilizated in into first track
In serve as holding parts, as long as can make reflector along the first track motion so as to realize neutron therapy device to irradiation space in
Irradiated body carries out the irradiation of different angle, is not just illustrated one by one herein.
The tube bank 20 has axis, during the tube bank 20 is including being fixed on the first tube bank 21 of accelerator 200, being fixed on
3rd tube bank 22 of sub- generating unit 11 and the second tube bank 23 being connected between the first tube bank 21 and the 3rd tube bank 22.The axle
Line includes the second axis II of the tube banks of first axle I and second 23 of the first tube bank 21.It is inclined that the deflection magnet 30 includes first
Turn the deflection magnet 32 of magnet 31 and second.One end of first tube bank 21 is connected to accelerator 200, and the other end is connected to first
Deflection magnet 31；One end of second tube bank 23 is connected to the first deflection magnet 31, and the other end is connected to the second deflection magnet
32；One end of 3rd tube bank 22 is connected to the first deflection magnet 31, and the other end is connected to the second deflection magnet 32 and is connected to
Between first tube bank 21 and the second tube bank 23.The beam-shaping body 10 can be around the first axle I or the of the first tube bank 21
The second axis II of three tube banks 22 is rotated to change irradiating angle of the beam-shaping body 10 to the irradiated body in irradiation space 50.
First 21 intermediate ion beam P of tube bank transmission direction is transmitted to the second tube bank 23 after being deflected by the first deflection magnet 31, the
Two 23 intermediate ion beam P of tube bank transmission direction is transmitted to the 3rd after being deflected by the second deflection magnet 32 restrains the 22, the 3rd
Ion beam P in tube bank 22 is transmitted to neutron generating unit 11 and then produced for neutron therapy device 100 to irradiated body progress
The neutron beam needed during irradiation.
Support frame as described above 60 is additionally provided with the second supporting part 62 above the first supporting part 61, second deflection magnet
32 are immobilizated in the second supporting part 62, and second supporting part 62, which is provided with, allows the second deflection magnet 32 as beam-shaping body 10 is transported
The second dynamic track 621.The concrete structure of second track 621 may be referred to hereinbefore be used to hold beam-shaping body 10 simultaneously
Allow the structure of the first track 611 of the motion of beam-shaping body 10, just no longer illustrate herein.Second supporting part 62 can also
As shown in fig. 7, it is arranged on the rear of the first supporting part 61.
The beam-shaping body 10 moves according to the different irradiating angles that irradiated body needs in the first track 611, when
Beam-shaping body 10 around first axle I rotate when, the 3rd tube bank 22 is moved with beam-shaping body 10, the second deflection magnet
32 move in the second track 621 under the drives of the motion of the 3rd tube bank 22, whereby to realize neutron therapy device 100 to irradiation
50 irradiated body carries out the irradiation of different angle in space.Certainly, the beam-shaping body 10 can also be arranged to around
The structure that the second axis II of two tube banks 23 is rotated also can be achieved on beam-shaping body 10 to irradiated body in irradiation space 50
Multi-angle irradiation, herein just no longer describe in detail.
As shown in Figure 7 and Figure 8, the first angle a1, the second tube bank are formed between the tube bank 23 of the first tube bank 21 and second
23 and the 3rd form the second angle a2, the first angle a1 and the second angle a2 size between tube bank and can change, can
It any one in the first angle a1 and the second angle a2 or two are arranged to angular dimension can change according to being actually needed
The structure of change, to reduce the limitation to the irradiating angle of beam-shaping body 10.
The neutron therapy device 100, which also has, is used to fixing the 3rd supporting part 63 of the first deflection magnet 31, and described the
Three supporting parts 63 can be with as shown in figure 9, be set directly on support frame 60, can also be as shown in figure 3, being directly anchored to ground.
The rotary course of whole neutron therapy device in the application embodiment is described in detail below.
First, direction of illumination is determined according to the concrete condition of irradiated body, makes beam whole according to the direction of illumination after determination
Body 10 moves to the position that can carry out the angular illumination in the first track 611, and the 3rd tube bank 22 is with beam-shaping
Body 10 positions after moving to a certain particular location；
Then, the is determined according to the position of the position of the first tube bank 21, the position of the 3rd tube bank 22 and the second tube bank 23
The yawing moment of one deflection magnet 31 and the second deflection magnet 32.Because the position of the first tube bank 21 is fixed, the 3rd tube bank
22 position is determined according to the movement position of beam-shaping body 10, and the second tube bank 23 is positioned at the first tube bank 21 and the 3rd tube bank 22
Between and the second deflection magnet 32 and the first deflection magnet 31 be each attached to tube bank 20 one end, therefore second tube bank 23 position can
To be the optional position that can be obtained in space after being determined by the position of the first tube bank 21 and the 3rd tube bank 22, after determination
The position of three sections of tube banks determines the yawing moment of the first deflection magnet 31 and the second deflection magnet 32, transmits autoacceleration device 200
Ion beam P out is transmitted to neutron generating unit 11.
First 21 intermediate ion beam P of tube bank transmission direction is transmitted after the first deflection magnet 31 changes to the second pipe
Beam 23, the second transmission direction for restraining 23 intermediate ion beam P are transmitted after being changed again via the second deflection magnet 32 to the 3rd pipe
Beam 22, the ion beam P direct irradiations in the 3rd tube bank 22 produce neutron beam, the neutron beam is to being shone to neutron generating unit 11
Beam is irradiated.
It is pointed out that although herein described slow beam-shaping body has function of shielding in itself, in order to right
Irradiated body obtains more preferable shield effectiveness during being irradiated treatment, can also additionally set and irradiation space is shielded
The shield covered.Especially when first track 611 is with irradiating the phase of space 50 from the recessed formation in the surface of the first supporting part 61
(with reference to Fig. 5) during 612 such case of accommodation space of connection, beam-shaping body 10, accommodation space 612 and irradiation space 50 it
Between form gap, on the one hand this gap can influence the overall appearance of neutron therapy device, on the other hand can also increase irradiation process
The leakage of middle radiation, it is therefore desirable to which setting is covered in accommodation space 612 and shielded in irradiation process to irradiation space 50
The shield 70 (70 ') covered.
With reference to diagram, the concrete structure of shield 70 (70 ') is illustrated, the shield 70 (70 ') can
Moved with the motion of beam-shaping body 10 and irradiation space 50 is shielded.
Join Figure 10 and Figure 11, the shield 70 include two can along beam-shaping body 10 the direction of motion stretching, extension or
The shielding part 71 of contraction.The shielding part 71 is located at the both sides of the beam-shaping body 10, one end of each shielding part 71 respectively
It is connected to the other end of support frame as described above 60 and is connected to the beam-shaping body 10.
The shielding part 71 is made up of the shielding part 72 of multiple head and the tail phase clasps, the end of the 72 mutual clasp of shielding part
Provided with holding section 73, the holding section 73 can be mobile on the surface of the shielding part 72 and mutually detained with adjacent holding section
Hold.When shielding part 71 shrinks, the shielding part 72 is stacked one by one；When the shielding part 71 trails, the screen
Cover portion 72 deploy one by one and mutually clasp and position two adjacent shielding parts 72.The shielding part 71 is the partially unfolded, is exactly
Say that partly shielding effect portion 72 trails as shown in Figure 10, partly shielding effect portion 72 is still stacked, in a word, the shielding part 72 with
The motion stretching, extension of beam-shaping body 10 or stack.
As shown in Figure 13 and Figure 14, when beam-shaping body 10 moves with respect to the first support frame 61, positioned at beam-shaping body
The shielding part 71 of 10 sides does contractile motion and gradually stacked, and the shielding part 71 for being located at the opposite side of beam-shaping body 10 does and stretched
Move and gradually extend.When the shielding part 72 is stacked, part of the shielding part 71 away from irradiation space 50 connects
The beam-shaping body 10 is connected to, the shielding part 71 is partially attached to support frame as described above 60 close to irradiation space 50.
Set as it was noted above, the first track 611 is arc-shaped, will each single shielding part 72 in present embodiment
It is arranged to arc-shaped to reach more preferable shield effectiveness.After the shielding part 72 trails one by one, the whole shielding part 71 is in
Arc-shaped.
In order to farthest reduce the leakage of radiation in irradiation process, the height H1 of the accommodation space 612 is set
The thickness (non-label) not less than the shield 70 is set to, the thickness of the shield 70 refers to that multiple shielding parts 72 are stacked on
Gross thickness together.Also, the width W2 of the shield 70 is not less than to the width W1 of the accommodation space 612.
Figure 15 show the another embodiment of the application shield 70 '.The shield 70 ' is connected to the beam
The both sides of shaping body 10 and formed it is previously described irradiation space 50.The shield 70 ' is monoblock type setting and can
(as shown in figure 16) is rotated around support frame as described above 61 with the motion of beam-shaping body 10, so as to enter to the irradiation space 50
Row shielding.In present embodiment, the shield 70 ' is contained in the accommodation space 612, the width W2 ' of the shield 70 '
Not less than the width W1 of the accommodation space 612, certainly, the thickness of the shield 70 ' is it can also be provided that no more than described
The height H1 of accommodation space 612.
The setting of shield 70 (70 ') on the one hand can shield the radiation leaked out by beam-shaping body 10, the opposing party
Face can be covered in the gap formed between irradiation space 50, accommodation space 612 and beam-shaping body 10, beneficial to integrated beauty
See.
Can be away from shield or close and can be held in furthermore it is also possible to be set in the outside of the shield
The barrier shield (non-label) of the shield.When the barrier shield is away from shield, beam-shaping body 10 is according to the actual requirements
Rotated on support frame as described above 60 to obtain suitable irradiation position, the shield is transported with the motion of beam-shaping body 10
Move and be covered in the irradiation space 50 all the time and irradiation space 50 is shielded；When the beam-shaping body 10 is positioned at suitable
Irradiation position after, the barrier shield is close and is held in the shield, the beam-shaping body 10 to irradiate space 50
It is irradiated, the shield shields to irradiation space 50.
On the one hand the setting of barrier shield provides support force for shield, shared the part support that support frame is born
Power；On the other hand can while shield is shielded to irradiation during it is caused radiation shield, enhance screen
Cover effect.
Arc-shaped as described herein not only includes certain section of circular shape on circle, by multistage straight line, rule or does not advise
The shape that curve then connects the similar circular arc to be formed belongs to arc-shaped described herein.
It should be appreciated that such as " having ", "comprising" and " comprising " term used herein are not precluded from one or more
The presence or addition of individual other compositions or its combination.
Although embodiment of the present invention is disclosed as above, it is not restricted in specification and embodiment listed
With.It can be applied to various suitable the field of the invention completely., can be easily for those skilled in the art
Realize other modification.Therefore it is of the invention and unlimited under the universal limited without departing substantially from claim and equivalency range
In specific details and shown here as the legend with description.
Claims (10)
1. a kind of neutron therapy device, it is characterised in that the neutron therapy device includes beam-shaping body, located at beam-shaping
Neutron generating unit in body, ion beam is sent to the tube bank of neutron generating unit, so that what direction of beam transport changed
Electromagnet and collimater are deflected, the beam-shaping body includes slow body and is packaged in the reflector in slow external week, described
Neutron generating unit produces neutron after ion beam irradiation, and the slow body will be from neutron degradation caused by neutron generating unit to default
Power spectrum, the neutron that the reflector will deviate from are led back to improve the neutron intensity in default power spectrum, and the collimater produces neutron
Neutron caused by life portion carries out cover, and the neutron therapy device has the irradiation space being irradiated to irradiated body,
The tube bank has axis, and the beam-shaping body can be rotated so as to the irradiated body in irradiation space around the axis of tube bank
Carry out the irradiation of different angle.
2. neutron therapy device according to claim 1, it is characterised in that the neutron therapy device also includes support
Frame, the beam-shaping body are immobilizated in support frame, also moved while beam-shaping body is around tube bank axis rotation on support frame.
3. neutron therapy device according to claim 1, it is characterised in that the tube bank includes first and restrained and with first
The 3rd tube bank that tube bank is connected, the axis includes the first axle of the first tube bank and the second axis of the 3rd tube bank, described to penetrate
Beam shaping body can rotate around the first axle of the first tube bank or the second axis of the 3rd tube bank.
4. neutron therapy device according to claim 3, it is characterised in that shape between first tube bank and the 3rd tube bank
Into the first angle, the position for being sized to change to adjust beam-shaping body with irradiate irradiated body in space of first angle
Put relation.
5. neutron therapy device according to claim 2, it is characterised in that support frame as described above includes the first supporting part, shines
Penetrate and be spatially located at below the first supporting part, first supporting part is provided with the first track, and the beam-shaping body is immobilizated in support
First track of frame, first track it is recessed in support frame so as to form the accommodation space being connected with irradiating space, it is described
Collimater extends into irradiation space from accommodation space.
6. neutron therapy device according to claim 5, it is characterised in that first supporting part is set for arc-shaped,
First track is to be set with the arc-shaped in the same center of circle of the first supporting part, circular arc of first track from the first supporting part
The recessed formation in surface.
7. neutron therapy device according to claim 3, it is characterised in that the tube bank also includes the second tube bank, described
Second tube bank is connected to neutron generating unit, and the second angle, second angle are formed between second tube bank and the 3rd tube bank
Be sized to change with adjust beam-shaping body with irradiate space in irradiated body position relationship.
8. the neutron therapy device described in claim 7, it is characterised in that the deflection magnet is immobilizated in support frame, described inclined
Turn magnet including the first deflection magnet between the first tube bank and the 3rd tube bank and positioned at the second tube bank and the 3rd tube bank
Between the second deflection magnet, it is described first tube bank intermediate ion beam transmission direction changed by the first deflection magnet after pass
Transport in the 3rd tube bank, the 3rd transmission direction for restraining intermediate ion beam is transmitted to second after being changed by the second deflection magnet
Tube bank, the ion beam irradiation in the second tube bank produce the neutron beam being irradiated for neutron ray device to neutron generating unit.
9. neutron therapy device according to claim 8, it is characterised in that support frame as described above is additionally provided with for supporting second
Second supporting part of deflection magnet, second supporting part are provided with the second track, when beam-shaping body moves in the first track
When, second supporting part moves in the second track.
10. neutron therapy device according to claim 7, it is characterised in that support frame as described above is additionally provided with the 3rd supporting part,
First deflection magnet is immobilizated in the 3rd supporting part, and first tube bank is fixed between accelerator and the first deflection magnet,
Second tube bank is connected between beam-shaping body and the second deflection magnet, and the 3rd tube bank is connected to the first deflection magnet
And second between deflection magnet.
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610517978.4A CN107569779B (en) | 2016-07-04 | 2016-07-04 | Neutron therapeutic device |
| PCT/CN2016/110396 WO2018006550A1 (en) | 2016-07-04 | 2016-12-16 | Neutron therapy device |
| EP16908054.6A EP3456381B1 (en) | 2016-07-04 | 2016-12-16 | Neutron therapy device |
| JP2018568668A JP6761876B2 (en) | 2016-07-04 | 2016-12-16 | Neutron therapy device |
| TW106207221U TWM549081U (en) | 2016-07-04 | 2017-05-19 | Neutron therapy device |
| TW106207223U TWM558633U (en) | 2016-07-04 | 2017-05-19 | Neutron therapy device |
| US16/212,995 US10556127B2 (en) | 2016-07-04 | 2018-12-07 | Neutron therapy apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610517978.4A CN107569779B (en) | 2016-07-04 | 2016-07-04 | Neutron therapeutic device |
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| CN107569779A true CN107569779A (en) | 2018-01-12 |
| CN107569779B CN107569779B (en) | 2024-03-22 |
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| CN201610517978.4A Active CN107569779B (en) | 2016-07-04 | 2016-07-04 | Neutron therapeutic device |
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| CN107569779B (en) | 2024-03-22 |
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