CN206443946U - A kind of nitrogen dioxide gas sterilizing cabinet for pre-filled syringes - Google Patents
A kind of nitrogen dioxide gas sterilizing cabinet for pre-filled syringes Download PDFInfo
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- CN206443946U CN206443946U CN201621101039.3U CN201621101039U CN206443946U CN 206443946 U CN206443946 U CN 206443946U CN 201621101039 U CN201621101039 U CN 201621101039U CN 206443946 U CN206443946 U CN 206443946U
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- nitrogen dioxide
- dioxide gas
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- sterilization container
- sterilizing cabinet
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Abstract
The utility model provides a kind of nitrogen dioxide gas sterilizing cabinet for pre-filled syringes, the residual device of vacuum/row, thermostat and humidification device are separately installed with the nitrogen dioxide air source generator being connected including sterilization container and by filling device with sterilization container, sterilization container；Gas cylinder heater and pre- chamber heater that nitrogen dioxide air source generator includes nitrogen dioxide gas cylinder, measures pre-chamber and be respectively arranged at nitrogen dioxide gas cylinder and metering pre-chamber bottom, connected between nitrogen dioxide gas cylinder and metering pre-chamber by gas pipeline, it is provided with gas pipeline in gas mass flow gauge, metering pre-chamber and diaphragm pressure sensor is installed.Nitrogen dioxide gas sterilizing cabinet of the present utility model has that sterilizing cost is low, sterilization time is short, remain than relatively low and i.e. workable advantage at normal temperatures；And the sterilizing cabinet is simple to operate, easy to use, with good application value.
Description
Technical field
The utility model belongs to medical equipment technical field, is related to a kind of sterilizing cabinet, more particularly to a kind of for pre-filled
The nitrogen dioxide gas sterilizing cabinet of injection.
Background technology
Liquid medicine prefilled injection (prefilled syringe, PFS) system is advance by decoction using certain technique
It is filling in syringe so as to a kind of form of medication that patient directly uses.Global 1st prefilled syringe was in birth in 1984
U.S. company BD is born in, so far the existing history of more than 30 years.The large biological molecules such as antibody drug, gene recombinant protein medicine, vaccine
Medicine is used for the treatment and prevention of the major diseases such as tumour, cardiovascular and cerebrovascular diseases, arthritis, hepatitis, AIDS.From disease treatment
For the aspect demand of epidemic prevention two, biologics are all in rapid growth period.The peptides and egg of PFS being suitably stable for property differences especially
White class medicine, including vaccine, albumin, interferon and antirheumatic etc..For the medicine that must be injected, load pre- embedding note
Its security is can ensure that in emitter.
And the property of biological products in itself determines that its major part need to be using injection system administration.Bio-pharmaceuticals in the last few years
Development and PFS growing maturation, PFS consumption has been promoted significantly.Compared with traditional ampoule bottle, cillin bottle, inoculated
The advantage for being filled with emitter is it will be apparent that with following technical advantage：It is a, safe and reliable, it is to avoid to be taken out repeatedly using after dilution
Inhale, glass powder is fallen into bottle when opening ampoule bottle, reduce the chance of cross pollution and secondary pollution, reduce many unexpected hairs
It is raw；B, for pharmacy corporation cost is saved, eliminate cleaning, silication such as toasts at the huge production line and corresponding factory building；Need not
Sterilizing, the quality-control cost (QA, QC etc.) of pharmacy corporation is greatly reduced；C, normal injection agent need overfilling 20%~
25%, youngster's pre-encapsulated injector reduces waste of the medicine caused by the absorption in storage and transfer process, particularly with costliness
Biochemical preparation, tool is of great significance；D, accurate dosage are preset, help pharmacy corporation saving cost, benefit,
Value-added content of product is improved, the class of product is improved；E, by the way of bottle placer quantitative filling decoction, it is more manual than medical personnel
Aspiration medicinal liquid is more accurate, it is to avoid risk caused by dosage errors；F, the title that can directly indicate medicine on the injector, it is clinical
On be not susceptible to mistake, if using easily peelable label, also helping the medication information for preserving patient；It is g, easy to operate, face
Compare the time that half is saved using ampoule in bed, be particularly suitable for Emergency Patients, cut down the number of intermediate links and win for danger, urgency, heavy patient
Rescue time.
Pre-encapsulated injector progressively replaces traditional glass ampule, cillin bottle, ordinary syringe in following several years, be through
The inevitable outcome of Ji development, pre-encapsulated injector necessarily turns into the main manner of packing of medicine.And pre-encapsulated injector is generally needed
Syringe and annex (syringe needle, boost motor etc.) are packaged in bubble-cap box, a face of bubble-cap box is by with gas permeability and energy
Intercept the nonwoven paper wrapper of bacterium.Pre-encapsulated injector is due to the particularity of application method, guarantee of the outer packing for aseptic
More strict, particularly for ophthalmology or the product of operating room aseptic area, medicine unless the context ensures sterile outer, also tackles
It carries out surface sterilizing processing, and ensures the gnotobasis in bubble-cap box, until the final Clinical practice of product.
There is the side such as steam sterilizing, gamma rays sterilizing, ethylene oxide sterilizing to the sterilization method of pre-encapsulated injector at present
Formula.Steam sterilizing is most common sterilization method, for thermal sensitivity medicine or biological products, and too high sterilising temp may also draw
Play the denaturation of product.And the product of pre-encapsulated injector is mostly biological products.Gamma rays causes medicine is exposed to have to break
In the radiation of bad property, the degraded for causing medicine or container encapsulant is easily caused, such as white high-density polyethylene bottle packaging
Easy flavescence；Aluminum-plastic packaged, PVC sides its colour changed into yellow, partially liq preparation color can deepen.Although ethylene oxide sterilizing is not
It is required that high temperature, but sterilising temp typically will be also controlled at 40~60 DEG C, and requires the vacuum of relative depth, and in sterilization process
Pressure change may cause the displacement of syringe rubber plug, whole sterilization process should be carried out under the supervision of person skilled in the art,
After sterilizing, fresh air should be taken to replace, residual ethylene oxide and other effumability residues is dissipated, ventilation and parsing are gone
Except residual is required for 10h or so.
Utility model content
Technical problem to be solved in the utility model is used in advance there is provided one kind for drawbacks described above of the prior art
Fill the nitrogen dioxide gas sterilizing cabinet of injection.
The utility model uses following technical scheme to solve above-mentioned technical problem：
The utility model provides a kind of nitrogen dioxide gas sterilizing cabinet for pre-filled syringes, including sterilization container
With the nitrogen dioxide air source generator being connected by filling device with the sterilization container, it is separately installed with the sterilization container
The residual device of vacuum/row, thermostat and humidification device；The nitrogen dioxide air source generator includes nitrogen dioxide gas cylinder, metering
Pre-chamber and the gas cylinder heater and the pre- chamber heater of metering for being respectively arranged at the nitrogen dioxide gas cylinder and metering pre-chamber bottom, institute
State and connected between nitrogen dioxide gas cylinder and the metering pre-chamber by gas pipeline, gas matter is installed on the gas pipeline
Measure and diaphragm pressure sensor is installed in flowmeter, the metering pre-chamber.
Further, the nitrogen dioxide gas cylinder at least two, and being arranged in parallel.
Further, the nitrogen dioxide air source generator also includes the pressure being sequentially arranged on the gas pipeline
Table, pressure switch, pressure-reducing valve, the first magnetic valve, needle-valve and the second magnetic valve.
Further, in addition to the metering pre-chamber vacuum extractor being connected, the vacuum extractor is included successively
Electromagnetic barriers valve, dry vacuum pump, blast pipe and the manual ball valve connected through pipeline；The vacuum extractor and the metering are pre-
The first absorption degradation room is provided between room.
Further, the nitrogen dioxide gas cylinder, the supply list of gas cylinder heater and part the gas pipeline composition
Member is positioned in glove box, be provided with the glove box content of nitrogen dioxide sensor, the second absorption degradation room and for
The safe blower fan of negative pressure is set up in the glove box.
Further, the filling device is made up of valve, blower fan, compressed air feeding pipe, gas displacement pipeline, is used
In by the pre- indoor NO of the metering2Filled into the sterilization container.
Further, the sterilization container is a closed container for being used to put the pre-filled syringes, and it includes
Mobile door, loader mechanism and the flow-disturbing blower fan that can be moved in parallel.
Further, vavuum pump is provided with the residual device of vacuum/row, the vavuum pump is connected with the sterilization container
For providing a vacuum environment to the sterilization container.
Further, the thermostat is by ring thermostat tube, electric heater, circulating pump, heat conduction silicone oil, expansion vessel, plate
Formula heat exchanger and temp probe composition, the ring thermostat tube is arranged on the casing both sides of sterilization container, for controlling sterilization container
Interior environment temperature.
Further, the humidification device is made up of ultrasonic humidifier, valve, blower fan, for controlling in sterilization container
Relative humidity.
The utility model uses above technical scheme, compared with prior art, has the following technical effect that：
Sterilized under a, normal temperature：NO2Lost activity as oxidant by microorganism as the degraded to DNA, it is pre- in metering
As long as ensureing temperature more than 21.2 DEG C in room and sterilization container, you can be sterilized at ambient pressure, the possibility not condensed is special
Shi He biological products and thermal sensitivity medicine not compared temperature with the sterilizing of sensitive product, and the gaseous state under normal temperature also allows
Sterilizing gas is more evenly distributed；
B, sterilizing cost are low：The sterilizing cabinet is installed and existing factory building need not be transformed on a large scale, and public work only has cold
But water, NO2, electricity and compressed air；High-purity more than 2000 yuan one bottle of nitrogen dioxide (99.995%) 10L (7Kg) steel loading bottle, for
Produce NO for pre-encapsulated injector pharmacy corporation2Sterilizing be one more rapidly with the more preferable sterilizing installation of Products Compatibility；
C, sterilization time are short：Humidification about 5 minutes, sterilization process 45 minutes, ventilation degradation time 30 minutes；Entirely
Sterilization process is time-consuming 90~120 minutes, and sterilization time is extremely short in gaseous sterilization；
D, residual are than relatively low：Sterilize and test bottom is less than to the level of liquid detecting nitrate in pre-encapsulated injector after terminating
Line (2 μ g/ml), the debris concentration 0.002ppm of pH test result nitrate is that European Union's States Pharmacopoeia specifications water for injection production is permitted
Perhaps 1 the percent of the minimum limitation 0.2ppm of nitrate.
Brief description of the drawings
Fig. 1 is a kind of structural representation of nitrogen dioxide gas sterilizing cabinet for pre-filled syringes of the utility model；
Fig. 2 is nitrogen dioxide source of the gas in a kind of nitrogen dioxide gas sterilizing cabinet for pre-filled syringes of the utility model
The structural representation of generator；
Fig. 3 is a kind of schematic flow sheet of nitrogen dioxide gas sterilizing cabinet for pre-filled syringes of the utility model；
Wherein, 1- gas cylinders heater, 2- temperature relays, the temp probes of 3- first, 4- nitrogen dioxide gas cylinders, 5- gas cylinder hands
Valve, 6- check valves, 7- pressure gauges, 8- pressure switches, 9- pressure-reducing valves, the magnetic valves of 10- first, 11- needle-valves, the electromagnetism of 12- second
Valve, 13- gas mass flow gauge, 14- metering pre-chamber, 15- second temperatures probe, 16- diaphragm pressure sensors, 17- it is pneumatic every
Film valve, the first absorption degradations of 18- room, 19- electromagnetic barriers valves, 20- dry vacuum pumps, 21- blast pipes, 22- manual ball valves, 23-
Pre- chamber heater, the temp probes of 24- the 3rd, 25- content of nitrogen dioxide sensors, the second absorption degradations of 26- room, 27- safety winds
Machine, 28- valves, 29- blower fans, 30- compressed air feeding pipes, 31- gas displacement pipelines, 32- movement door 33- loader mechanisms,
34- flow-disturbing blower fans, 35- vavuum pumps, 36- ring thermostat tubes, 37- electric heaters, 38- circulating pumps, 39- heat conduction silicone oil, 40- expansion capacities
Device, 41- plate type heat exchangers, 42- temp probes, 43- valves, 44- ultrasonic humidifiers, 45- blower fans.
Embodiment
The technical solution of the utility model is described in further detail below in conjunction with the accompanying drawings.
As shown in figure 1, the utility model provides a kind of nitrogen dioxide gas sterilizing cabinet for pre-filled syringes, it is main
Want nitrogen dioxide air source generator A, filling device B, sterilization container C, vacuum/row residual device D, thermostat E, humidification device F
Six apparatus system compositions.
As shown in Fig. 2 the air source generator mainly includes：Nitrogen dioxide gas cylinder 4；Pass through gas transmission with nitrogen dioxide gas cylinder 4
The metering pre-chamber 14 of pipeline connection；Gas cylinder heater 1 and pre-chamber that respectively nitrogen dioxide gas cylinder 4 and metering pre-chamber 14 are heated
Heater 23, and be nitrogen dioxide gas cylinder 4 and the temperature of metering pre-chamber 14 by gas cylinder heater 1 and the control of pre- chamber heater 23
For 45 DEG C.Gas cylinder hand valve 5 and check valve 6 are installed in the nitrogen dioxide gas cylinder 4, prevent extraneous gas from entering oxidation nitrogen cylinder 4；
The temp probe 3 of temperature relay 2 and first, the temperature for being precisely controlled nitrogen dioxide gas cylinder 4 are installed on gas cylinder heater 1
Degree.Meanwhile, second temperature probe 15 and diaphragm pressure sensor 16 are also equipped with metering pre-chamber 14, in pre- chamber heater 23
3rd temp probe 24 is installed, the temperature for measuring pre-chamber 14 accurately controlled with realizing.
Gas mass flow gauge 13 is installed on gas pipeline, and diaphragm pressure is installed in metering pre-chamber 14 and is sensed
Device 16；Pressure gauge 7, pressure switch 8, pressure-reducing valve 9, the first magnetic valve 10, needle-valve 11 and are also equipped with gas pipeline
Two magnetic valves 12.The first absorption degradation room 18 is provided between vacuum extractor and metering pre-chamber.And in the first absorption degradation room
Pneumatic diaphragm valve 17 is installed on pipeline between 18 and metering pre-chamber 14.The vacuum extractor is by electromagnetic barriers valve 19, dry type
Vavuum pump 20, blast pipe 21 and manual ball valve 22 are constituted.
Nitrogen dioxide gas cylinder 4, the gas cylinder heater 1 heated for nitrogen dioxide gas cylinder 4 and part gas pipeline composition are supplied
Gas unit, as shown in dotted portion in Fig. 2, air supply unit is positioned in glove box to prevent air supply unit from leaking, part
Gas pipeline includes being provided with pressure gauge 7, pressure switch 8, the gas pipeline of the magnetic valve 10 of pressure-reducing valve 9 and first.By
Content of nitrogen dioxide sensor 25, the second absorption degradation room 26 and the peace for setting up negative pressure in glove box are installed on glove box
Full blast machine 27, is monitored and is carried out the use peace that degradation treatment ensures air supply unit in real time with the leakage situation to air supply unit
Entirely.
As shown in figure 3, filling device B is by valve 28, blower fan 29, compressed air feeding pipe 30, gas displacement pipeline 31
Composition, mainly completes N2O4To NO2Conversion, according to sterilization container C volume metering NO2Usage amount, for pre-chamber will to be measured
Interior NO2Filled into sterilization container C.Sterilization container C be according to the volumes of wanted sterilising prods, one of quantitative design it is closed
Container, it is pre- for putting by being constituted including a mobile door 32 that can be moved in parallel, loader mechanism 33 and flow-disturbing blower fan 34
Fill injection.Vavuum pump 35 is provided with the residual device D of vacuum/row, vavuum pump 35 is connected with sterilization container C for holding to sterilizing
Device C provides a vacuum environment, facilitates NO2From metering pre-chamber to sterilization container C transfer, vacuum environment has been also convenient for NO in addition2
Being uniformly distributed in sterilization container, after sterilizing terminates under the alternating action of compressed air and vacuum in exchange system
NO2, pass through the NO in absorption degradation unit and in gas2, it is ensured that exhaust is environmentally safe.Thermostat E is by ring thermostat tube
36th, electric heater 37, circulating pump 38, heat conduction silicone oil 39, expansion vessel 40, plate type heat exchanger 41 and temp probe 42 are constituted, permanent
Winchester disk pipe 36 is arranged on sterilization container C casing both sides, mainly by the heating cooling of conduction oil 39 to control sterilizing to hold
Environment temperature in device C.And humidification device F is made up of ultrasonic humidifier 44, valve 43, blower fan 45, major function is control
Relative humidity in sterilization container processed, allows sterilization process to be carried out under a specific humidity, it is ensured that the effect of sterilizing.
The sterilization process flow of nitrogen dioxide gas sterilizing cabinet of the present utility model for pre-filled syringes be divided into
Under several steps carry out：
Step 1, sterilize set-up procedure：Nitrogen dioxide gas cylinder is preheated, heating-up temperature is 45~50 DEG C, pressure switch control
Storage pressure, which rises to more than 0.5Bar, can carry out sterilizing gas metering；First metering pre-chamber is carried out being evacuated down to setting
Value, carries out heating-up temperature to metering pre-chamber and also controls at 45~50 DEG C；Then magnetic valve injection NO2 is opened to set when pressure rises to
Level pressure force value, sterilizing gas metering is completed；Compressed air is finally filled with to pre- interior is measured, pressure is raised to 1Bar；
Step 2, humidification：Humidification uses ultrasonic humidifier, and water source uses water for injection, and the higher-order of oscillation makes water fogging
As 1~5 micron of ultramicron, water smoke is sent in the space of sterilization container by the blower fan of an interior circulation, blower fan
Collect folk songs also in sterilization container, humidification is a closed circulation, it is to avoid ambient atmos enter；Preferably, sterilization container
Interior general humidification is to 80% relative humidity, the best results sterilized under the humidity；
Step 3, sterilization process：Sterilizing can with normal-pressure sterilization, can also vacuum sterilization because NO2Molecular weight be
46.01, the molecular weight of air is 29；In order to ensure NO2It can be evenly distributed in sterilization container, it is proposed that if conditions permit is tried one's best
Sterilized using vacuum method；But the problem of to consider plug displacement in pre-encapsulated injector sterilization process, general sterilization container
Be evacuated down to 400mmHg (measure the displacement and pressure of plug between 150~220mmHg through research experiment, specific pressure value with
The fit tolerance of plug and syringe, the material of plug, lubricant etc. has relation)；Open between metering pre-chamber and sterilization container
Valve, by the distributor on sterilization container top by NO2It is filled with sterilization container, then will be measured by the blower fan of interior circulation
Pre- indoor NO2Fully bring into sterilization container；Flow-disturbing blower fan at the top of pneumatic sterilization container, allows NO2It is distributed in sterilization container
Uniformly, after circulating 10 minutes, the valve closed between metering pre-chamber and sterilization container closes interior circulation blower fan, flow-disturbing blower fan；Then
Again setting value is evacuated down to metering pre-chamber, NO is filled with again2, bacterium container is also evacuated down to 400mmHg, pulses 3 times again
Sterilizing terminates afterwards.
Step 4, ventilation degradation process：
Sterilizing pulsation exhaust process and sterilizing terminate exhaust process, are required for degraded absorption from metering pre-chamber and sterilization container
The gas of interior discharge, it is to avoid pollution environment, it is preferred to use the corrosion-resistant vavuum pump discharge gas of dry type；Degradator is arranged on vavuum pump
Air entry, the acid wood activated charcoal of filling and the active aluminium ball of 10% sodium permanganate in degraded, activated carbon can only adsorb NO2, no
Reaction；10% sodium permanganate activity aluminium ball and NO2 reaction mass ratio are 15:1；Safety is mounted with the blast pipe of vavuum pump
The sensor of concentration, the NO2 concentration of the gas of monitoring discharge in real time；If there is concentration over-standard, sound and light alarm is sent, us are reminded
The degradable material more crossed in price reduction device.
The sterilization processes of pre-filled syringes are completed by above step using the nitrogen dioxide gas sterilizing cabinet, this is used for
The nitrogen dioxide gas sterilizing cabinet of pre-filled syringes can be used at normal temperatures, be adapted to biological products and thermal sensitivity medicine to temperature
Degree compares the sterilizing of sensitive product；Sterilizing cabinet is installed and existing factory building need not be transformed on a large scale, effectively reduces and sterilizes into
This；Whole sterilization process is time-consuming 90~120 minutes, and sterilization time is extremely short in gaseous sterilization, is set with existing sterilizing
It is standby to compare, substantially reduce sterilization time short；And sterilizing terminates the debris concentration 0.002ppm of rear nitrate, residual compares
It is low.
Specific embodiment of the utility model is described in detail above, but it is only used as example, the utility model
It is not restricted to particular embodiments described above.To those skilled in the art, it is any that the practicality is equal
Modifications and substitutions are also all among category of the present utility model.Therefore, the institute in the case where not departing from spirit and scope of the present utility model
The impartial conversion and modification of work, should all cover in the range of the utility model.
Claims (10)
1. a kind of nitrogen dioxide gas sterilizing cabinet for pre-filled syringes, it is characterised in that including sterilization container and pass through
Be separately installed with the nitrogen dioxide air source generator that filling device is connected with the sterilization container, the sterilization container vacuum/
Arrange residual device, thermostat and humidification device；The nitrogen dioxide air source generator include nitrogen dioxide gas cylinder, metering pre-chamber and
It is respectively arranged at the gas cylinder heater and pre- chamber heater of the nitrogen dioxide gas cylinder and metering pre-chamber bottom, the nitrogen dioxide
Connected between gas cylinder and metering pre-chamber by gas pipeline, gas mass flow gauge, the meter are installed on the gas pipeline
Diaphragm pressure sensor is installed in amount pre-chamber.
2. nitrogen dioxide gas sterilizing cabinet according to claim 1, it is characterised in that the nitrogen dioxide gas cylinder is at least
Two, and be arranged in parallel.
3. nitrogen dioxide gas sterilizing cabinet according to claim 1, it is characterised in that the nitrogen dioxide air source generator
Also include being sequentially arranged at pressure gauge on the gas pipeline, pressure switch, pressure-reducing valve, the first magnetic valve, needle-valve and the
Two magnetic valves.
4. nitrogen dioxide gas sterilizing cabinet according to claim 1, it is characterised in that also including connecting with the metering pre-chamber
The vacuum extractor connect, the vacuum extractor includes electromagnetic barriers valve, dry vacuum pump, the blast pipe connected successively through pipeline
And manual ball valve；The first absorption degradation room is provided between the vacuum extractor and the metering pre-chamber.
5. nitrogen dioxide gas sterilizing cabinet according to claim 1, it is characterised in that the nitrogen dioxide gas cylinder, gas cylinder
The air supply unit of heater and part the gas pipeline composition is positioned in glove box, and dioxy is provided with the glove box
Change nitrogen concentration sensor, the second absorption degradation room and the safe blower fan for setting up negative pressure in the glove box.
6. nitrogen dioxide gas sterilizing cabinet according to claim 1, it is characterised in that the filling device is by valve, wind
Machine, compressed air feeding pipe, gas displacement pipeline composition, for measuring pre- indoor NO by described2To the sterilization container
Interior filling.
7. nitrogen dioxide gas sterilizing cabinet according to claim 1, it is characterised in that the sterilization container, which is one, to be used for
The closed container of the pre-filled syringes is put, it includes the mobile door, loader mechanism and flow-disturbing blower fan that can be moved in parallel.
8. nitrogen dioxide gas sterilizing cabinet according to claim 1, it is characterised in that set on the residual device of vacuum/row
Vavuum pump is equipped with, the vavuum pump is connected with the sterilization container for providing a vacuum environment to the sterilization container.
9. nitrogen dioxide gas sterilizing cabinet according to claim 1, it is characterised in that the thermostat is by constant temperature disk
Pipe, electric heater, circulating pump, heat conduction silicone oil, expansion vessel, plate type heat exchanger and temp probe composition, the ring thermostat tube peace
Mounted in the casing both sides of sterilization container, for controlling the environment temperature in sterilization container.
10. nitrogen dioxide gas sterilizing cabinet according to claim 1, it is characterised in that the humidification system is by ultrasonic wave
Humidifier, valve, blower fan composition, for controlling the relative humidity in sterilization container.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201621101039.3U CN206443946U (en) | 2016-09-30 | 2016-09-30 | A kind of nitrogen dioxide gas sterilizing cabinet for pre-filled syringes |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201621101039.3U CN206443946U (en) | 2016-09-30 | 2016-09-30 | A kind of nitrogen dioxide gas sterilizing cabinet for pre-filled syringes |
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| CN206443946U true CN206443946U (en) | 2017-08-29 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109720658A (en) * | 2018-11-27 | 2019-05-07 | 上海翡诺医药设备有限公司 | A kind of hydrogen peroxide vacuum and low temperature disinfection system and method |
| US11085016B1 (en) | 2020-01-20 | 2021-08-10 | Chio Kang Medical, Inc. | Method for screening bacteria capable of degrading ethylene oxide |
| US11103608B1 (en) | 2020-07-03 | 2021-08-31 | Chio Kang Medical, Inc. | Mobile pretreatment apparatus and an operating method thereof, and a mobile analysis apparatus and an operating method thereof |
| US11110390B1 (en) | 2020-03-18 | 2021-09-07 | Chio Kang Medical, Inc. | Systems and methods for treating sterilization exhaust gas containing ethylene oxide |
| US11123680B1 (en) | 2020-03-18 | 2021-09-21 | Chio Kang Medical, Inc. | Devices, systems, and methods for treating ethylene oxide waste gas |
| US11123449B1 (en) | 2020-07-03 | 2021-09-21 | Chio Kang Medical, Inc. | Mobile sterilization system, mobile execution system, and mobile analysis system |
| US11125498B1 (en) | 2020-03-18 | 2021-09-21 | Chio Kang Medical, Inc. | Gas liquefaction separator, gas liquefaction recovery system, and method for separating and recovering ethylene oxide |
| US11124438B2 (en) | 2020-01-20 | 2021-09-21 | Chio Kang Medical, Inc. | Alcaligenes faecalis for degrading ethylene oxide |
| US11130939B2 (en) | 2020-01-20 | 2021-09-28 | Chio Kang Medical, Inc. | Bacteria for degrading ethylene oxide and uses thereof |
| US11136253B1 (en) | 2020-03-18 | 2021-10-05 | Chio Kang Medical, Inc. | Microbiological treatment system for ethylene oxide exhaust gas |
| WO2022000460A1 (en) * | 2020-07-03 | 2022-01-06 | Qiaokang Biotech (Guangdong) Co., LTD. | Container sterilization device and system, assembling method thereof, and use thereof |
| US11220667B2 (en) | 2020-01-20 | 2022-01-11 | Chio Kang Medical, Inc. | Bacteria for degrading ethylene oxide and applications thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109720658A (en) * | 2018-11-27 | 2019-05-07 | 上海翡诺医药设备有限公司 | A kind of hydrogen peroxide vacuum and low temperature disinfection system and method |
| US11085016B1 (en) | 2020-01-20 | 2021-08-10 | Chio Kang Medical, Inc. | Method for screening bacteria capable of degrading ethylene oxide |
| US11124438B2 (en) | 2020-01-20 | 2021-09-21 | Chio Kang Medical, Inc. | Alcaligenes faecalis for degrading ethylene oxide |
| US11130939B2 (en) | 2020-01-20 | 2021-09-28 | Chio Kang Medical, Inc. | Bacteria for degrading ethylene oxide and uses thereof |
| US11220667B2 (en) | 2020-01-20 | 2022-01-11 | Chio Kang Medical, Inc. | Bacteria for degrading ethylene oxide and applications thereof |
| US11110390B1 (en) | 2020-03-18 | 2021-09-07 | Chio Kang Medical, Inc. | Systems and methods for treating sterilization exhaust gas containing ethylene oxide |
| US11123680B1 (en) | 2020-03-18 | 2021-09-21 | Chio Kang Medical, Inc. | Devices, systems, and methods for treating ethylene oxide waste gas |
| US11125498B1 (en) | 2020-03-18 | 2021-09-21 | Chio Kang Medical, Inc. | Gas liquefaction separator, gas liquefaction recovery system, and method for separating and recovering ethylene oxide |
| US11136253B1 (en) | 2020-03-18 | 2021-10-05 | Chio Kang Medical, Inc. | Microbiological treatment system for ethylene oxide exhaust gas |
| US11103608B1 (en) | 2020-07-03 | 2021-08-31 | Chio Kang Medical, Inc. | Mobile pretreatment apparatus and an operating method thereof, and a mobile analysis apparatus and an operating method thereof |
| US11123449B1 (en) | 2020-07-03 | 2021-09-21 | Chio Kang Medical, Inc. | Mobile sterilization system, mobile execution system, and mobile analysis system |
| WO2022000460A1 (en) * | 2020-07-03 | 2022-01-06 | Qiaokang Biotech (Guangdong) Co., LTD. | Container sterilization device and system, assembling method thereof, and use thereof |
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