CN206339492U - A kind of biological chips detection system - Google Patents

Abstract

The utility model discloses a kind of biological chips detection system, feature is to include carrying case, there is a glove cavity in carrying case, detection means and enriching apparatus are provided with glove cavity, reagent accepting rack, hybridizing box accepting rack and chip accepting rack are provided with the lateral wall of carrying case, stored in reagent accepting rack and be provided with hybridizing reagent, stored in hybridizing box accepting rack and be provided with hybridizing box, stored on chip accepting rack and be provided with biochip, the front end of carrying case is provided with opening, opening is connected with glove cavity, and hatch door is movably provided with opening.Advantage is its neat small volume, is easy to movement, simple in construction, easy to use.

Description

A kind of biological chips detection system

Technical field

The utility model is related to biochip test field, more particularly, to a kind of biological chips detection system.

Background technology

Biochip（Biochip or bioarray）It is according to the principle specifically interacted between biomolecule, by biochemistry Process integration is analyzed in chip surface, so as to realize the high flux to DNA, RNA, polypeptide, protein and other biological composition Quick detection.The biochip concept of narrow sense refers to biomolecule by distinct methods（Oligonucleotides, cDNA, genomic DNA, polypeptide, antibody, antigen etc.）It is bonded to silicon chip, sheet glass（Pearl）, plastic sheet（Pearl）, gel, in the solid phase mediator such as nylon membrane The biomolecule dot matrix of formation.The concept of chip takes from integrated concept, and biochip is the integrated of biomaterial.As experiment Room detection is the same, and blood glucose, albumen, enzymatic activity etc. are checked on biochip, is based on same biological respinse principle.So raw Thing chip is exactly a carrier platform, is a carrier, is in base by discontinuous analysis process integration in life science The miniature biochemical analysis system on piece surface, to realize to the accurate, fast of cell, protein, gene and other biological components Speed, the detection of large information capacity.The technical advantage that biochip possesses makes detection quicker, sensitive and accurate.Conventional biology Chip detection needs to use the equipment such as nucleic acid augmentative instrument, chip hybridization instrument, chip cleaner and detector.In the market upper State a whole set of related equipment not only expensive, and volume is heavy greatly, should not often move, and it is mobile difficult larger.

The content of the invention

Technical problem to be solved in the utility model is to provide a kind of small volume and is easy to mobile biochip test System.

The utility model solve the technical scheme that is used of above-mentioned technical problem for：

There is a glove cavity in a kind of biological chips detection system, including carrying case, described carrying case, described puts It is provided with detection means and enriching apparatus in thing cavity, reagent accepting rack, hybridization is provided with the lateral wall of described carrying case Stored in box accepting rack and chip accepting rack, described reagent accepting rack and be provided with hybridizing reagent, described hybridizing box accepting rack Interior storage, which is provided with to store on hybridizing box, described chip accepting rack, is provided with biochip, and the front end of described carrying case is set Opening is equipped with, described opening is connected with described glove cavity, and hatch door is movably provided with described opening.

Described carrying case includes a horizontally disposed base plate, and the both sides of described base plate are vertically provided with side plate respectively, It is connected between side plate described in two by an arc backboard, described hatch door is to be engaged with described arc backboard radian Arc, be provided with arc chute on the madial wall of the side plate described in two from front to back, the both sides of described hatch door Respectively slidably it is arranged in described arc chute, it is necessary to which when opening described hatch door, the described hatch door of operation makes it Slided backward along described arc chute, when described hatch door is opened completely, described hatch door is located at described arc Before backboard.Above-mentioned carrying case is simple in construction, hatch door folding with convenience.

Described detection means includes light source mechanism, biochip loader mechanism and image capturing mechanism, described light source Mechanism is arranged on the lower section of described biochip loader mechanism, and described image capturing mechanism is arranged on described biochip The top of loader mechanism.Biochip is loaded with biochip loader mechanism, light source is provided for biochip by light source mechanism, Then the image information on biochip is captured by image capturing mechanism, simple in construction, good portability and can obtained more Accurately observe result.

Described biochip loader mechanism includes to be provided with up and downly in load frame, described load frame Pedestal is loaded, the upper surface of described loading pedestal is provided with the slot inserted for described biochip from top to bottom, described The front end face of loading pedestal be provided with observation opening, described observation opening is connected with described slot, described observation The width of opening, which is less than on the width of described slot, described loading pedestal, to be provided with for driving described loading pedestal to exist The position adjusting mechanism of the up and down loading base position with described in adjustment in described load frame.The biology of said structure Chip loader mechanism is simple in construction, easy to operate, and the width of watch window is less than the width of slot, is not influenceing the premise of observation Under, it can effectively prevent that the biochip being inserted into slot from dropping out from watch window, it is adjustable self-contained by position adjusting mechanism The upper-lower position of pedestal is carried, is easy to carry out complete observation to biochip.

The first insert port corresponding with described slot position is provided with described arc backboard, biochip passes through institute The first insert port stated is inserted into slot, simple in construction, easy to operate.

Be provided with described hatch door with first described insert port size the second insert port of identical, when described hatch door When opening completely before being placed in described arc backboard, described the second insert port and the first described insert port aligned in position, Biochip passes sequentially through the first insert port and the insertion of the second insert port is set in slot, simple in construction, easy for operation.

Described position adjusting mechanism includes adjusting rod, two adjusting knobs and two regulation gears, described adjusting rod It is located on described loading pedestal and is rotationally erected between the side plate described in two, and the two ends of described adjusting rod Described side plate is stretched out respectively, and the adjusting knob described in two is respectively fixedly disposed at the two ends of described adjusting rod, two institutes The regulation gear stated is fixedly installed on described adjusting rod, and the both sides of described loading pedestal are respectively arranged with regulation chute, Regulation gear described in two is separately positioned in the regulation chute described in two, the front inner wall of each described regulation chute On be provided with the tooth bar being meshed with described regulation gear.Above-mentioned position adjusting mechanism is simple in construction, easy to operate, passes through two Individual side plate gives adjusting rod one stable installation positioning, during regulation, rotates adjusting knob, adjusting rod ensues rotation, drives The regulation pinion rotation being fixed thereon, regulation pinion rotation drives the tooth bar motion being engaged with, so as to drive loading pedestal It is up and down.

Described image capturing mechanism includes mobile phone with camera function and shelves branch for shelve described mobile phone Frame, described shelving support include above shelving plate and under shelve plate, it is described on shelve the both sides of plate and be separately fixed at two institutes The front end face of plate is shelved on the inner face for the side plate stated and on described just to described opening, it is described on shelve the bottom of plate Be provided with height regulating rod movable up and down, the lower end of described height regulating rod be fixedly installed on it is described under shelve plate Upper surface, it is described under shelve the front end of plate and be extended forward and have lower location-plate, described lower location-plate is arranged on described Under shelve the bottom of plate, it is described on shelve and be provided with plate a watch window, can be horizontally slipped on described watch window Ground is provided with viewing head installing plate, and the rear end of described viewing head installing plate, which is provided with viewing head, described viewing head, to be set Have be provided with the first peep hole of front and rear insertion, described viewing head installing plate it is corresponding with described first observation hole site and The second peep hole being connected, the front end of described viewing head is fixedly installed on the rear end face of described viewing head installing plate, The front end face of described load frame is provided with the 3rd peep hole, and the 3rd described peep hole is just to described observation opening, institute The rear end for the viewing head stated is fixedly installed on through the 3rd described peep hole in described load frame, the first described observation Lens are provided with hole.Above-mentioned image capturing mechanism is simple in construction, easy to operate, the lens set in the first peep hole, passes through Biological information on biochip is amplified by lens；Shelving support for placing mobile phone be divided into shelve plate and under shelve Two parts of plate, under shelve the upper-lower position of plate and can be adjusted by height regulating rod so that the shelving support can be adapted to The mobile phone of different length, lower location-plate plays a part of lower positioning to mobile phone, it is ensured that mobile phone can stably be seated in and shelve branch On frame；Viewing head installing plate slidingly can be arranged on watch window, and diverse location is arranged on available for adaptation camera Mobile phone.When specifically used, mobile phone is seated on shelving support, the right position of viewing head installing plate is adjusted, makes on mobile phone Camera can be directed at the second peep hole, the height for shelving plate is adjusted down by height regulating rod so that when taking the photograph on mobile phone When being directed at the second peep hole as head, the bottom of mobile phone, which can stablize, be shelved on lower location-plate, and lens are by the life on biochip Thing information is amplified, and the pictorial information on biochip is captured by the mobile phone with camera function.

Shelved on described and be provided with the first guide chute in plate from top to bottom, in the first described guide chute can above and below The first lead column is slidably provided with, the first described lead column is fixedly installed on the upper end of described height regulating rod, described The first lead column external diameter be more than described height regulating rod external diameter, it is described on shelve plate lower surface be provided with it is logical Hole, described through hole is connected with the first described guide chute, and described through hole is stretched out in the lower end of described height regulating rod, The internal diameter of described through hole is more than the external diameter of described height regulating rod and less than the external diameter of the first described lead column, described On shelve the upper surface of plate and be provided with internal thread hole, described internal thread hole is connected with the first described guide chute, described Internal thread hole on be bolted with lock-screw, the position of described height regulating rod is locked by lock-screw.Pass through The cooperation of first guide chute and the first lead column, the motion to height regulating rod play the guiding role, the external diameter of the first lead column More than the external diameter of height regulating rod, the internal diameter of through hole is more than external diameter of the external diameter less than the first lead column of height regulating rod, it is ensured that Height regulating rod can be swimmingly up and down and can be stably mounted to shelve on plate；On shelve the upper surface of plate and be provided with Be bolted with lock-screw in internal thread hole, internal thread hole, under shelve plate height regulation after the completion of, by tighten lock-screw will The position of height regulating rod is fixed.

The front end face that plate is shelved under described is provided with a groove, described groove and is provided with a guide plate, described Being set side by side with up and down in guide plate can left and right in the second guide chute of two transverse directions, each the second described guide chute The second lead column is slidably provided with, described the inner of the second lead column is set between the first madial wall of described groove There is back-moving spring, the outer end of the second described lead column is connected with width adjusting bar, one end of the width adjusting bar described in two It is connected by a postive stop baffle, one end of described guide plate is fixedly installed on the first madial wall of described groove, institute The other end for the guide plate stated is provided with guide through hole, and described guide through hole is connected with the second guide chute, described width Spend adjusting rod and stretch out described guide through hole, the external diameter of the second described lead column is more than the external diameter of described width adjusting bar, The internal diameter of described guide through hole is more than the external diameter of described width adjusting bar and less than the external diameter of the second described lead column.On When stating structure so that mobile phone is shelved on shelving support, right position can be also accurately positioned, and pass through the second guide chute Guide effect is played to the motion of width adjusting bar with the second lead column, back-moving spring gives postive stop baffle one tightening force, second The external diameter of lead column is more than the external diameter of width adjusting bar, and the internal diameter of guide through hole is more than the external diameter of width adjusting bar and less than second The external diameter of lead column so that width adjusting bar can swimmingly horizontally slip and with a stable positioning.

Chute is provided with the upper interior end face of described watch window and bottom inner face, described viewing head is installed The upper surface and lower surface of plate are provided with the sliding block being engaged with described chute, and described sliding block is slidably disposed on institute In the chute stated.Horizontally slipping for viewing head installing plate is realized by chute and sliding block, the hand of different camera positions can be adapted to Machine, it is simple in construction, it is easy to operate.

Plate is shelved on described and tilts backwards setting.On shelve plate tilt backwards setting cause whole shelving support inclination set Put, be easy to shelving for mobile phone, mobile phone can be prevented effectively from and slid accidentally.

Described light source mechanism includes light source, light source circuit board and the battery case for putting battery, described light source electricity Be laid with the circuit of light sources for controlling described light source switch on the plate of road, described light source and described battery case respectively with institute The circuit of light sources electrical connection stated, described circuit of light sources is provided with two access ports mutually disconnected, and described access port is set On described base plate, the access port conduction panel of conduction is provided with the upper surface of described hatch door, when hatch door is opened completely, The two ends of described access port conduction panel are in contact with the access port described in two by described circuit of light sources conducting respectively.It is above-mentioned Light source mechanism is simple in construction, and conductive access port conduction panel is set in the upper surface of hatch door, light source is realized by the folding of hatch door Opening and closing, it is easy to operate and economize on electricity.

The outside portion of each described side plate is provided with a protective cover, the side of described protective cover be provided with it is described Protective cover mounting bracket, described protective cover mounting bracket are provided with the regulation through hole that adjusting knob is engaged, described protective cover Including mounting post and mounting bracket, described mounting post can slidingly be arranged on described adjusting rod and be arranged on described Between side plate and described adjusting knob, described mounting bracket includes the support being symmetricly set on described mounting post side wall Bar, one end of described support bar is fixedly installed on the side wall of described mounting post, and the other end of described support bar is outside Bending is fixedly connected in 90 ° of kink with the inwall of described protective cover, and described adjusting knob is arranged on described in two Between kink.The reagent accepting rack, hybridizing box accepting rack and chip accepting rack that are arranged on side plate are carried out by protective cover Proofing dust and protecting, when needing to use the article in above-mentioned accepting rack, it is only necessary to which protective cover is outwards pulled open, side simple to operate Just.

Described enriching apparatus includes being provided with immunomagnetic beads in test tube and magnetic separation rack, described test tube, described Magnetic separation rack include it is horizontally disposed shelve plate and shelve base plate, it is described to shelve plate and shelve between base plate by vertical Supporting plate support is fixed, and is provided with magnet in described supporting plate, and described shelving is set on plate multiple to be had and described test tube What is matched shelves through hole, and described test tube is shelved on described shelve in through hole.The enriching apparatus is simple in construction, operation side Just, Biosample is poured into the test tube equipped with immunomagnetic beads when using, the biology matched with the immunomagnetic beads is by immune magnetic Pearl is adsorbed, and the test tube that then will be equipped with Biosample is shelved on magnetic separation rack, will be adsorbed with by the magnet in supporting plate The biological immunomagnetic beads of detection is adsorbed onto on test tube wall, is then poured out remaining Biosample, and just can effectively be enriched to needs The biological specimen to be detected.

Described hybridizing box includes hybridizing box box body, and described hybridizing box box body includes a horizontally disposed substrate, described Substrate on multiple windows to lower recess are arranged side by side, the edge of described window is provided with the sample-adding of a up/down perforation Hole, the both sides of described substrate are respectively arranged with the supporting walls bent downwards, and described supporting walls mutually hang down with described substrate It is straight to set, the chute of oriented described supporting walls outer wall direction depression, described chute are set on the inwall of described supporting walls Width and the thickness of biochip match.

The bottom face of described window uses transparent material, when described biochip is inserted into described chute, The sample area of the described biochip surface of described window alignment, the bottom face and described biochip of described window Gap is provided between upper surface, described gap forms chip conversion zone.Window bottom face uses transparent material, works as biology When chip is inserted, the sample area on biochip can be accurately placed under the window by operator through the transparent window Side, is easy to accurately enter chip conversion zone by well containing the solution for hybridizing composition, and in biochip surface Sample is contacted, and completes hybridization, it is ensured that the success rate of hybridization.

Described gap is 0.2-0.5mm.The interstice coverage is suitable chip conversion zone scope.

One end of described substrate is provided with arc-shaped recess.Fetching for biochip is easy in the setting of the arc-shaped recess.

Compared with prior art, the utility model has the advantage of：By the detection means and richness for biochip test Acquisition means are incorporated into the carrying case of an entirety, and reagent accepting rack, hybridization are provided with by the box body lateral wall of carrying case Box accepting rack and chip accepting rack, are respectively used to store the corresponding thing for biochip test by above-mentioned accepting rack Product, its neat small volume is easy to movement, simple in construction, easy to use, while setting opening on carrying case so that detection dress Putting to be directly anchored in carrying case, it is not necessary to which taking-up is used, and be easy to be provided with mobilizable hatch door, hatch door in operation, opening Cause that glove cavity is closed during closing, play protection and dust-proof effect.

Brief description of the drawings

Fig. 1 is overall structure diagram of the present utility model；

Fig. 2 pulls open the structural representation under state for the utility model hatch door opening, protective cover；

Fig. 3 removes protective cover for Fig. 1, opens the structural representation of hatch door；

Fig. 4 is Fig. 2 back structures schematic diagram；

Fig. 5 is the structural representation of biochip loader mechanism in the utility model；

Fig. 6 is the structural representation of loading pedestal in the utility model；

Fig. 7 is the cross section structure diagram of loading pedestal in the utility model；

Fig. 8 is the structural representation of shelving support in the utility model；

Fig. 9 is the cross section structure diagram of shelving support in the utility model；

Figure 10 is the structural representation of light source mechanism in the utility model；

Figure 11 is the structural representation of protective cover in the utility model；

Figure 12 is the structural representation of enriching apparatus in the utility model；

Figure 13 is the structural representation of hybridizing box in the utility model embodiment two；

Figure 14 is inserted into the structural representation in hybridizing box for biochip in the utility model embodiment two；

Figure 15 is the structural representation of hybridizing box in the utility model embodiment three；

Figure 16 is inserted into the structural representation in hybridizing box for biochip in the utility model embodiment three.

Embodiment

The utility model is described in further detail below in conjunction with accompanying drawing embodiment.

Embodiment one：As illustrated, having one to put in a kind of biological chips detection system, including carrying case A, carrying case A It is provided with thing cavity A1, glove cavity A1 on detection means and enriching apparatus, carrying case A lateral wall and is provided with reagent storage Stored in frame A2, hybridizing box accepting rack A3 and chip accepting rack A4, reagent accepting rack A2 and be provided with hybridizing reagent, hybridizing box is stored Store to be provided with to store on hybridizing box A5, chip accepting rack A4 in frame A3 and be provided with biochip B3, carrying case A front end is set There are opening A6, opening A6 to be connected with glove cavity A1, hatch door A7 is movably provided with opening A6.

In this particular embodiment, carrying case A includes a horizontally disposed base plate A8, and base plate A8 both sides are vertically set respectively It is equipped between side plate A9, two side plate A9 and is connected by an arc backboard A10, hatch door A7 is and arc backboard A10 radian phases Arc chute A91, hatch door A7 both sides point are provided with the arc of cooperation, two side plate A9 madial wall from front to back It is not slidably disposed in arc chute A91, it is necessary to which when opening hatch door A7, operation hatch door A7 makes it along arc chute A91 is slided backward, when hatch door A7 is opened completely, and hatch door A7 is located at before arc backboard A10.Above-mentioned carrying case A is simple in construction, Hatch door A7 folding with convenience.

In this particular embodiment, detection means includes light source mechanism, biochip loader mechanism and image capturing mechanism, Light source mechanism is arranged on the lower section of biochip loader mechanism, and image capturing mechanism is arranged on the upper of biochip loader mechanism Side.Biochip B3 is loaded with biochip loader mechanism, light source is provided for biochip B3 by light source mechanism, then passes through Image information on image capturing mechanism capture biochip B3, simple in construction, good portability and can be obtained more accurately Observe result.

In this particular embodiment, biochip loader mechanism includes load frame 1, can be up and down in load frame 1 Ground is provided with loading pedestal 2, and the upper surface for loading pedestal 2 is provided with the slot 21 inserted for biochip B3, dress from top to bottom The front end face for carrying pedestal 2 is provided with observation opening 22, and observation opening 22 is connected with slot 21, and the width of observation opening 22 is less than The width of slot 21, load be provided with pedestal 2 for drive load pedestal 2 in load frame 1 it is up and down to adjust dress Carry the position adjusting mechanism of the position of pedestal 2.The biochip loader mechanism of said structure is simple in construction, easy to operate, observation window The width of mouth 22 is less than the width of slot 21, on the premise of observation is not influenceed, can effectively prevent the life being inserted into slot 21 Thing chip B3 is dropped out from watch window 22, by the adjustable upper-lower position for loading pedestal 2 of position adjusting mechanism, is easy to opposite Thing chip B3 carries out complete observation.

In this particular embodiment, first insert port A101 corresponding with the position of slot 21 is provided with arc backboard A10, Biochip B3 is inserted into slot 21 by the first insert port A101, simple in construction, easy to operate.

In this particular embodiment, it is provided with hatch door A7 and first insert port A101 sizes the second insert port of identical A71, when before hatch door A7 being opened be placed in arc backboard A10 completely, the second insert port A71 and the first insert port A101 positions pair Together, biochip B3 passes sequentially through the first insert port A101 and the second insert port A71 insertions and is set in slot 21, simple in construction, It is easy for operation.

In this particular embodiment, position adjusting mechanism includes adjusting rod 3, two adjusting knobs 4 and two regulation gears 5, adjusting rod 3 is located on loading pedestal 2 and is rotationally erected between two side plate A9, and the two ends difference of adjusting rod 3 Side plate A9 is stretched out, two adjusting knobs 4 are respectively fixedly disposed at the two ends of adjusting rod 3, and two regulation gears 5 are fixedly installed on tune On pole 3, the both sides for loading pedestal 2 are respectively arranged with regulation chute 23, and two regulation gears 5 are separately positioned on two regulation cunnings In groove 23, the tooth bar 231 being meshed with regulation gear 5 is provided with the front inner wall of each regulation chute 23.Adjust above-mentioned position Save mechanism structure simple, it is easy to operate, positioned, during regulation, rotated to 3 one stable installations of adjusting rod by two side plate A9 Adjusting knob 4, adjusting rod 3 ensues rotation, drives the regulation gear 5 being fixed thereon to rotate, and regulation gear 5, which is rotated, to be driven The tooth bar 231 being engaged with is moved, so as to drive loading pedestal 2 up and down.

In this particular embodiment, image capturing mechanism includes the mobile phone with camera function（Do not shown in figure）With for The shelving support D of placing mobile phone, shelving support D include above shelve plate D1 and under shelve plate D2, above shelve plate D1 both sides difference Be fixed on two side plate A9 inner face and on shelve plate D1 front end face just to opening A6, the bottom for above shelving plate D1 is set There is height regulating rod D3 movable up and down, height regulating rod D3 lower end is fixedly installed on down the upper surface for shelving plate D2, under Shelving plate D2 front end and being extended forward has lower location-plate D4, lower location-plate D4 to be arranged on down the bottom for shelving plate D2, on Shelve to be provided with plate D1 on a watch window D11, watch window D11 and can slidingly be provided with viewing head installing plate D5, Viewing head installing plate D5 rear end is provided with the first peep hole D61 that front and rear insertion is provided with viewing head D6, viewing head D6, sees Examine and the second peep hole D51 that is corresponding with the first peep hole D61 positions and being connected is provided with an installing plate D5, viewing head D6's Front end is fixedly installed on viewing head installing plate D5 rear end face, and the front end face of load frame 1 is provided with the 3rd peep hole 11, the Three peep holes 11 are just to observation opening 22, and viewing head D6 rear end is fixedly installed in load frame 1 through the 3rd peep hole 11, Lens D62 is provided with first peep hole D61.Above-mentioned image capturing mechanism is simple in construction, easy to operate, the first peep hole D61 Biological information on biochip B3, is amplified by the lens D62 of interior setting by lens D62；For putting for placing mobile phone Put support D be divided to for above shelve plate D1 and under shelve two parts of plate D2, under shelve plate D2 upper-lower position can by height adjust Bar D3 is adjusted so that the shelving support can be adapted to the mobile phone of different length, and lower location-plate D4 plays lower positioning to mobile phone Effect, it is ensured that mobile phone can be stably seated on shelving support D；Viewing head installing plate D5 can slidingly be arranged on sight Examine on window D11, the mobile phone of diverse location is arranged on available for adaptation camera.When specifically used, mobile phone is seated in and shelved On support D, adjustment viewing head installing plate D5 right position enables the camera on mobile phone to be directed at the second peep hole D51, led to Cross the height that plate D2 is shelved under height regulating rod D3 regulations so that when the camera on mobile phone is directed at the second peep hole D51, hand The bottom of machine, which can stablize, shelves D on lower location-plate D4, and lens D62 amplifies the biological information on biochip B3, passes through Pictorial information on mobile phone capture biochip B3 with camera function.

In this particular embodiment, height regulating rod D3 is 2, is separately positioned on the both sides for shelving plate D1 bottoms.2 It is stable that height regulating rod D3 setting make it that height is adjusted.

In this particular embodiment, above shelve in plate D1 and be provided with the first guide chute D12 from top to bottom, first is oriented to cunning It can slide up and down in groove D12 and be provided with the first lead column D13, the first lead column D13 and be fixedly installed on height regulating rod D3's Upper end, the first lead column D13 external diameter is more than height regulating rod D3 external diameter, and the lower surface for above shelving plate D1 is provided with through hole D14, through hole D14 are connected with the first guide chute D12, and through hole D14 is stretched out in height regulating rod D3 lower end, and through hole D14's is interior Footpath be more than height regulating rod D3 external diameter and less than the first lead column D13 external diameter, above shelve plate D1 upper surface be provided with Screwed hole D16, internal thread hole D16 are connected with the first guide chute D12, and lock-screw D15 is bolted with internal thread hole D15, Height regulating rod D3 position is locked by lock-screw D15.Pass through the first guide chute D12 and the first lead column D13 cooperation, the motion to height regulating rod D3 play the guiding role, and the first lead column D13 external diameter is more than height regulating rod D3 External diameter, the external diameter that through hole D14 internal diameter is more than height regulating rod D3 is less than the first lead column D13 external diameter, it is ensured that height is adjusted Pole D3 can be swimmingly up and down and can be stably mounted to shelve on plate D1；On shelve plate D1 upper surface and be provided with Lock-screw D15 is bolted with internal thread hole, internal thread hole, under shelve plate D2 height regulation after the completion of, by tightening locking Screw D15 fixes height regulating rod D3 position.

In this particular embodiment, the front end face that plate D2 is shelved under is provided with a groove D21, groove D21 and is provided with one The second guide chute D221 of two transverse directions is set side by side with guide plate D22, guide plate D22 up and down, each second is oriented to cunning The second lead column D23, the second lead column D23 the inner and the first of groove D21 can be slidingly provided with groove D221 The outer end that back-moving spring D24, the second lead column D23 are provided between madial wall D211 is connected with width adjusting bar D25, two wide Degree adjusting rod D25 one end is connected by a postive stop baffle D26, and guide plate D22 one end is fixedly installed on the of groove D21 On one madial wall D211, the guide plate D22 other end is provided with guide through hole (not shown), and guide through hole is oriented to second Chute D221 is connected, and width adjusting bar D25 stretches out guide through hole, and the second lead column D23 external diameter is more than width adjusting bar D25 External diameter, the internal diameter of guide through hole is more than width adjusting bar D25 external diameter and the external diameter less than the second lead column D23.Above-mentioned knot When structure make it that mobile phone is shelved on shelving support D, right position can be also accurately positioned, and pass through the second guide chute D221 Guide effect is played to width adjusting bar D25 motion with the second lead column D23, and back-moving spring D24 is to postive stop baffle D26 mono- Tightening force, the second lead column D23 external diameter is more than width adjusting bar D25 external diameter, and the internal diameter of guide through hole is more than width adjusting Bar D25 external diameter and the external diameter less than the second lead column D23 so that width adjusting bar D25 swimmingly can horizontally slip and have There is a stable positioning.

In this particular embodiment, it is provided with chute on watch window D11 upper interior end face and bottom inner face D111, viewing head installing plate D5 upper surface and lower surface are provided with the sliding block D52 being engaged with chute D111, sliding block D52 It is slidably disposed in chute D111.Viewing head installing plate D5 left and right is realized by chute D111 and sliding block D52 cooperation Slide, the mobile phone of different camera positions can be adapted to, it is simple in construction, it is easy to operate.

In this particular embodiment, above shelve plate D1 and tilt backwards setting.On shelve plate D1 tilt backwards setting cause it is whole Individual shelving support D is obliquely installed, and is easy to shelving for mobile phone, can be prevented effectively from mobile phone and be slid accidentally.

In this particular embodiment, light source mechanism includes light source 6, light source circuit board 61 and the battery case for putting battery 7, be laid with the circuit of light sources for controlling light source 6 to switch on light source circuit board 61, light source 6 and battery case 7 respectively with light source electricity Road is electrically connected, and circuit of light sources is provided with two access ports mutually disconnected, and access port is arranged on base plate A8, hatch door A7 upper end The access port conduction panel of conduction is provided with face, when hatch door A7 is opened completely, the two ends of access port conduction panel respectively with two Circuit of light sources is in contact and turn on by access port.Above-mentioned light source mechanism is simple in construction, and conductive connect is set in hatch door A7 upper surface Entrance conduction panel, the opening and closing of light source, easy to operate and economize on electricity are realized by hatch door A7 folding.

In this particular embodiment, each side plate A9 outside portion is provided with a protective cover 8, and the side of protective cover 8 is set Have and protective cover mounting bracket is provided with the regulation through hole 81 being engaged with adjusting knob 4, protective cover 8, protective cover mounting bracket includes Mounting post 9 and mounting bracket 10, mounting post 9 can slidingly be arranged on adjusting rod 3 and be arranged on side plate A9 and adjusting knob 4 Between, mounting bracket 10 includes the support bar 101 being symmetricly set on the side wall of mounting post 9, and one end of support bar 101 is fixedly installed on On the side wall of mounting post 9, the other end outward bending of support bar 101 is fixed in the inwall of 90 ° of kink 102 and protective cover 8 Connection, adjusting knob 4 is arranged between two kinks 102.The reagent accepting rack being arranged on by 8 pairs of protective cover on side plate A9 A2, hybridizing box accepting rack A3 and chip accepting rack A4 carry out proofing dust and protecting, when needing to use the article in above-mentioned accepting rack, only Need outwards to pull open protective cover 8, it is simple to operate.

Embodiment two：Other parts are identical with embodiment one, and its difference is that enriching apparatus includes test tube C2 and magnetic Property separator frame C3, be provided with immunomagnetic beads C21 in test tube C2, magnetic separation rack C3 includes horizontally disposed shelving plate C31 and putting Bottom set plate C32, shelves plate C31 and shelves to support by vertical supporting plate C33 between base plate C32 and fix, set on supporting plate C33 Be equipped with magnet, shelve set on plate C31 it is multiple have and test tube C2 matches shelves through hole C311, test tube C2, which is shelved on, shelves logical In the C311 of hole.The enriching apparatus is simple in construction, easy to operate, and Biosample is poured into the examination equipped with immunomagnetic beads C21 when using In pipe C2, adsorbed with the biology that immunomagnetic beads C21 matches by immunomagnetic beads C21, then will be equipped with the test tube of Biosample C2 is shelved on magnetic separation rack C3, and will be adsorbed with the biological immunomagnetic beads C21 of detection by the magnet on supporting plate C33 adsorbs Onto test tube C2 walls, then remaining Biosample is poured out, the biological specimen for needing to detect just can be effectively enriched to.As schemed Shown in 12.

In this particular embodiment, as shown in Figure 13, Figure 14, hybridizing box B includes hybridization box body, and hybridization box body includes Multiple window B11 to lower recess are arranged side by side on one horizontally disposed substrate B1, substrate B1, window B11 edge is set Have a well B12 of a up/down perforation, substrate B1 both sides are respectively arranged with the supporting walls B2 bent downwards, supporting walls B2 with Substrate B1 is arranged in a mutually vertical manner, and the chute B21 of oriented supporting walls B2 outer walls direction depression, chute are set on supporting walls B2 inwall The thickness of B21 width and biochip B3 matches.

In this particular embodiment, window B11 bottom face uses transparent material, when biochip B3 is inserted into chute When in B21, window B11 is directed at the sample area on biochip B3 surfaces, window B11 bottom face and biochip B3 upper surface Between be provided with gap, the gap formed chip conversion zone.Window B11 bottom faces use transparent material, as biochip B3 During insertion, the sample area on biochip B3 can accurately be placed in window B11's by operator through the transparent window B11 Lower section, is easy to the solution containing hybridization composition accurately to enter chip conversion zone by well B12, with biochip B3 tables Sample contact on face, completes hybridization, it is ensured that the success rate of hybridization.

In this particular embodiment, above-mentioned gap is 0.2mm.

In this particular embodiment, aperture is gradually small in funnel-form from top to bottom by well B12, is mutually fitted with suction pipette head Match somebody with somebody, be easy to the insertion of suction pipette head, while enabling solution accurately to drip to the sample region location on biochip B3 surfaces.

Embodiment three：Other parts are identical with embodiment two, and its difference is that substrate B1 one end is provided with arc Be recessed B13.Fetching for biochip B3 is easy in arc-shaped recess B13 setting, as shown in Figure 15, Figure 16.

Example IV：Other parts are identical with embodiment two, embodiment three, and its difference is that gap is 0.3mm.

Embodiment five：Other parts are identical with embodiment two, embodiment three, and its difference is that gap is 0.4mm.

Embodiment six：Other parts are identical with embodiment two, embodiment three, and its difference is that gap is 0.5mm.

Claims (10)

1. a kind of biological chips detection system, it is characterised in that including carrying case, has a glove cavity in described carrying case, It is provided with detection means and enriching apparatus in described glove cavity, reagent storage is provided with the lateral wall of described carrying case Stored in frame, hybridizing box accepting rack and chip accepting rack, described reagent accepting rack and be provided with hybridizing reagent, described hybridizing box Store in accepting rack to be provided with to store on hybridizing box, described chip accepting rack and is provided with biochip, described carrying case Front end is provided with opening, and described opening is connected with described glove cavity, and cabin is movably provided with described opening Door.

2. a kind of biological chips detection system as claimed in claim 1, it is characterised in that described carrying case includes a level The base plate of setting, the both sides of described base plate are vertically provided between side plate, the side plate described in two respectively is carried on the back by an arc Plate is connected, and described hatch door is the arc being engaged with described arc backboard radian, the inner side of the side plate described in two Arc chute is provided with wall from front to back, the both sides of described hatch door are respectively slidably arranged on described circular arc , it is necessary to which when opening described hatch door, the described hatch door of operation makes it be slided backward along described arc chute in chute, when When described hatch door is opened completely, described hatch door is located at before described arc backboard.

3. a kind of biological chips detection system as claimed in claim 2, it is characterised in that described detection means includes light source Mechanism, biochip loader mechanism and image capturing mechanism, described light source mechanism are arranged on described biochip loading machine The lower section of structure, described image capturing mechanism is arranged on the top of described biochip loader mechanism.

4. a kind of biological chips detection system as claimed in claim 3, it is characterised in that described biochip loader mechanism Including load frame, loading pedestal, the described upper end for loading pedestal can be provided with described load frame up and downly Face is provided with the slot inserted for described biochip from top to bottom, and the front end face of described loading pedestal is provided with observation and opened Mouthful, described observation opening is connected with described slot, and the width of described observation opening is less than the width of described slot, Be provided with described loading pedestal for drive described loading pedestal in described load frame it is up and down with adjust The position adjusting mechanism of described loading base position.

5. a kind of biological chips detection system as claimed in claim 4, it is characterised in that described position adjusting mechanism includes Adjusting rod, two adjusting knobs and two regulation gears, described adjusting rod is located on described loading pedestal and rotatable Ground is erected between the side plate described in two, and described side plate is stretched out at the two ends of described adjusting rod respectively, described in two Adjusting knob is respectively fixedly disposed at the two ends of described adjusting rod, and the regulation gear described in two is fixedly installed on described tune On pole, the both sides of described loading pedestal are respectively arranged with regulation chute, and the regulation gear described in two is separately positioned on two In individual described regulation chute, it is provided with and is meshed with described regulation gear on the front inner wall of each described regulation chute Tooth bar.

6. a kind of biological chips detection system as claimed in claim 5, it is characterised in that described image capturing mechanism includes Mobile phone with camera function and the shelving support for shelving described mobile phone, described shelving support include above shelving plate and Under shelve plate, it is described on shelve the both sides of plate and be separately fixed on the inner face of the side plate described in two and shelved on described The front end face of plate just to described opening, it is described on shelve the bottom of plate and be provided with height regulating rod movable up and down, institute The lower end for the height regulating rod stated be fixedly installed on it is described under shelve the upper surface of plate, it is described under shelve the front end of plate towards Preceding be extended has a lower location-plate, described lower location-plate be arranged on it is described under shelve the bottom of plate, it is described on shelve plate On be provided with a watch window, described watch window and can slidingly be provided with viewing head installing plate, described observation The rear end of head installing plate is provided with the first peep hole that front and rear insertion is provided with viewing head, described viewing head, described sight Examine and the second peep hole that is corresponding with the first described observation hole site and being connected, described viewing head are provided with an installing plate Front end be fixedly installed on the rear end face of described viewing head installing plate, the front end face of described load frame is provided with the 3rd Peep hole, the 3rd described peep hole is just to described observation opening, and the rear end of described viewing head is seen through the described the 3rd Examine hole to be fixedly installed in described load frame, lens are provided with the first described peep hole.

7. a kind of biological chips detection system as claimed in claim 6, it is characterised in that shelved on described in plate from upper It is arranged with to slide up and down in the first guide chute, the first described guide chute and is provided with the first lead column, it is described First lead column is fixedly installed on the upper end of described height regulating rod, and the external diameter of the first described lead column is more than described height Spend the external diameter of adjusting rod, it is described on shelve the lower surface of plate and be provided with through hole, described through hole is oriented to described first to be slided Groove is connected, and described through hole is stretched out in the lower end of described height regulating rod, and the internal diameter of described through hole is more than described height The external diameter of adjusting rod and less than the external diameter of the first described lead column, it is described on shelve the upper surface of plate and be provided with internal thread Hole, described internal thread hole is connected with the first described guide chute, and lock-screw is bolted with described internal thread hole, leads to Cross lock-screw the position of described height regulating rod is locked.

8. a kind of biological chips detection system as claimed in claim 6, it is characterised in that the front end face of plate is shelved under described It is provided with a groove, described groove and is provided with a guide plate, two transverse directions is set side by side with up and down in described guide plate The second guide chute, can slidingly be provided with the second lead column in the second each described guide chute, it is described The inner of second lead column is provided with back-moving spring between the first madial wall of described groove, described the second lead column Outer end is connected with width adjusting bar, and one end of the width adjusting bar described in two is connected by a postive stop baffle, and described leads On the first madial wall that described groove is fixedly installed on to one end of plate, the other end of described guide plate is provided with guiding and led to Hole, described guide through hole is connected with the second guide chute, and described width adjusting bar stretches out described guide through hole, described The external diameter of the second lead column be more than the external diameter of described width adjusting bar, the internal diameter of described guide through hole is more than described width Spend the external diameter of adjusting rod and less than the external diameter of the second described lead column.

9. a kind of biological chips detection system as claimed in claim 3, it is characterised in that described light source mechanism include light source, It is laid with light source circuit board and the battery case for putting battery, described light source circuit board for controlling described light source to open The circuit of light sources of pass, described light source and described battery case are electrically connected with described circuit of light sources respectively, described light source electricity Road is provided with two access ports mutually disconnected, and described access port is arranged on described base plate, the upper end of described hatch door The access port conduction panel of conduction is provided with face, when hatch door is opened completely, the two ends of described access port conduction panel respectively with Access port described in two is in contact described circuit of light sources conducting.

10. a kind of biological chips detection system as claimed in claim 5, it is characterised in that the outside portion of each described side plate A protective cover is provided with, the side of described protective cover is provided with the regulation through hole being engaged with described adjusting knob, described Protective cover on be provided with protective cover mounting bracket, described protective cover mounting bracket includes mounting post and mounting bracket, described installation Post can slidingly be arranged on described adjusting rod and be arranged between described side plate and described adjusting knob, described Mounting bracket include the support bar being symmetricly set on described mounting post side wall, one end of described support bar is fixedly installed on On the side wall of described mounting post, the other end outward bending of described support bar is in 90 ° of kink and described protective cover Inwall be fixedly connected, described adjusting knob is arranged between the kink described in two.