CN206262569U - For in-vitro diagnosis equipment and with elliptical openings reaction warehouse - Google Patents
For in-vitro diagnosis equipment and with elliptical openings reaction warehouse Download PDFInfo
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- CN206262569U CN206262569U CN201621251585.5U CN201621251585U CN206262569U CN 206262569 U CN206262569 U CN 206262569U CN 201621251585 U CN201621251585 U CN 201621251585U CN 206262569 U CN206262569 U CN 206262569U
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Abstract
The utility model discloses a kind of reaction warehouse for in-vitro diagnosis equipment and with elliptical openings, including warehouse of the top with retainer plate, warehouse is made up of bin and orlop, bin is formed by upper bin and the linking of lower bin, the upper shed of upper bin is ellipsoidal structure, upper bin side wall is taper type structure, lower bin side wall is taper type structure, taper of the taper of lower bin side wall more than upper bin side wall, the cross-sectional profiles line of upper bin side wall and lower bin side wall is oval with upper bin upper shed shape identical, and orlop is circular arc bottom；Enriching apparatus are provided with the side wall of lower bin.The utility model advantage is simple structure, easy to use；Lower bin has heating, vortex cushioning effect and enrichment, it is to avoid wall built-up phenomenon occurs, reaction reagent is sufficiently mixed uniformly；Orlop is circular arc bottom, be easy to imbibition completely, avoid the useless capacity in warehouse bottom from minimizing；Enrichment shortens enrichment time apart from short, improves detection efficiency.
Description
Technical field
The utility model is related to the reaction warehouse of in-vitro diagnosis equipment, more particularly, to one kind for in-vitro diagnosis equipment and band
There is the reaction warehouse of elliptical openings.
Background technology
The target DNA of denier can be expanded up to a million times by gene amplification also known as cell-free assay cloning system, so that
The analysis to target DNA molecule and detectability are greatly improved, unique DNA can be detected or to only containing one in every 90,000 cells
The sample of target DNA molecule, thus diagnostic field is rapidly developed in vitro, for detecting the diseases such as hereditary disease, infectious disease.Often
In-vitro diagnosis the equipment such as instrument such as automatic chemiluminescence immunoassay system, Biochemical Analyzer and gene amplification are combined into
Integrally carry out the diagnosis of various diseases or virus.According to statistics, the key factor for now resulting in gene magnification detection failure is to carry
Pure quality out of control and cause the loss of target DNA or be contaminated, thus purification after target DNA is replicated is to directly affect gene expansion
Increase the key operation of reaction, directly affect the accuracy of disease detection result.The reaction warehouse used in purification step is for obtaining
The medical disposable material or repeatable consumptive material of purification are obtained, it is mainly used in the samples such as serum, blood, urine, blood plasma, marrow
The purification of target DNA, it is desirable to have receive the reaction compartment of mixture；In detection process, reaction warehouse should be met with automation instrument
The action docking of device equipment, meets types of functionality demand and anti-pollution demand, and obtain height with this according to its operation program again
The purified of quality and then ensure the success rate and accuracy of amplified reaction.Existing reaction warehouse mixing is uneven, and reactant mixture is easy
There is wall built-up phenomenon；When carrying out fluid injection with liquid injection pipe, fluid injection position is close to orlop, and capacity is small；Enrichment distance is big, with target DNA
Magnetic bead reagent enrichment time is long, and then influences the accuracy of sample detection.
Utility model content
The utility model purpose is to provide a kind of reaction warehouse for in-vitro diagnosis equipment and with elliptical openings.
To achieve the above object, the utility model takes following technical proposals：
Reaction warehouse for in-vitro diagnosis equipment and with elliptical openings described in the utility model, including top is with solid
The warehouse of fixed circle, the warehouse is made up of bin with the orlop for being arranged on the bin bottom, and the bin is by upper bin with
Bin linking is formed, and the upper shed of the upper bin is ellipsoidal structure, the side wall of upper bin be from the retainer plate bottom to
Taper type structure receive in upper bin lower open end, up big and down small, the lower bin side wall be from lower bin lower end to
The up big and down small taper type structure received in the orlop, the taper of the taper more than upper bin side wall of lower bin side wall,
The cross-sectional profiles line of the side wall of the side wall of upper bin and lower bin is tie oval with upper bin upper shed shape identical
Structure, orlop is circular arc bottom；Enriching apparatus are provided with the side wall of lower bin.
The wall thickness of the upper and lower bin is 0.4~1.0mm.
The fluid injection position of the bin is located at the lower bin side wall top at the enriching apparatus upper side position.
The utility model advantage is simple structure, easy to use；The side wall of lower bin uses taper type structure, lower bin
The cross-sectional profiles of side wall are ellipse, are not only used directly for heating response reagent, while also having vortex cushioning effect
And enrichment, it is to avoid there is wall built-up phenomenon, while making reaction reagent be sufficiently mixed uniformly；Orlop is circular arc bottom, is easy to imbibition
Completely, the useless capacity in warehouse bottom is avoided to minimize；The enrichment of reagent shortens enrichment time apart from short in warehouse, accelerates reaction,
Improve detection efficiency.
Brief description of the drawings
Fig. 1 is structural representation of the present utility model.
Fig. 2 is the overlooking the structure diagram of Fig. 1（Conceal enriching apparatus）.
Fig. 3 is dimensional structure diagram of the present utility model（Conceal enriching apparatus）.
Specific embodiment
As shown in Figure 2 and Figure 3, the reaction warehouse for in-vitro diagnosis equipment and with elliptical openings described in the utility model,
Including warehouse of the top with retainer plate 1, the warehouse is made up of bin with the orlop 2 for being arranged on the bin bottom, described
Bin is formed by upper bin 3 and the linking of lower bin 4, and the upper shed 5 of the upper bin 3 is ellipsoidal structure, the side wall of upper bin 3
Be taper type structure received from the lower open end of the bottom up bin 3 of the retainer plate 1, up big and down small, it is described under
The side wall of bin 4 is to the up big and down small taper type structure received in the orlop 2, the lower side of bin 4 from the lower end of lower bin 4
More than the taper of the side wall of upper bin 3, the cross-sectional profiles line of the side wall of the side wall of upper bin 3 and lower bin 4 is the taper of wall
With the shape identical ellipsoidal structure of 3 upper shed of upper bin 5, it is easy to fluid injection and vortex, orlop 2 is circular arc bottom；As shown in figure 1,
Enriching apparatus 6 are being provided with the side wall of lower bin 4 of ellipse short shaft one end, are reducing enrichment distance, shortening enrichment time, carried
High workload efficiency, enriching apparatus 6 may move, and need to be removed enriching apparatus 6 during vortex mixed, be easy to be well mixed, and reaction terminates
Enriching apparatus 6 are recovered to home position afterwards, is easy to enrichment, the magnetic bead reagent after enrichment is in the absorption of wire in the side of lower bin 4
The inner surface of wall.
During actual manufacture, warehouse is structure as a whole, and the wall thickness of upper bin 3 and lower bin 4 is 0.7mm（Can also 0.4~
Other any numbers of 1.0mm）, lower bin 4 is up big and down small taper type structure, is provided with the side of lower bin 4 of enriching apparatus 6
Wall has fluid injection, enrichment, directly to the side wall heating of lower bin 4 can be heated evenly, it is to avoid occur hanging in vortex blending process
Wall phenomenon, upper bin 3 has keeps away position effect；Warehouse is easy to reagent to flow using the smooth polypropylene material in surface, saves into
This.
During fluid injection, as shown in figure 1, fluid injection position is located on the side wall of lower bin 4 at the upper side position of the enriching apparatus 6
Side, the axis where liquid injection pipe 7 intersects with the upside of enriching apparatus 6 at the sidewall locations of lower bin 4, and reaction reagent directly drips
Enter in the side wall inner surfaces of lower bin 4 at the position that is connected with enriching apparatus 6, and along the inner surface of the side wall of lower bin 4
Orlop 2 is flowed into, it is to avoid cause wall built-up phenomenon because fluid injection position is too high, while avoiding influenceing reaction to try because fluid injection position is too low
The vortex effect of agent, improves the accuracy of sample detection result.
The course of work of the present utility model is summarized as follows：
When mixing operation be vortexed, enriching apparatus 6 are removed, to magnetic bead reagent is added in bin, then to bin
Interior injection reaction reagent, axis and the enriching apparatus 6 being located at the side wall link position of lower bin 4 during fluid injection where liquid injection pipe 7
Upside is intersected, and reaction reagent flows downwardly into orlop 2 along the inner surface of the side wall of lower bin 4, and orlop 2 is circular arc bottom, according to vortex
Principle, the reaction reagent for flowing into orlop 2 is vortexed upwards along lower wall, then falls into bin again in the presence of self gravitation
It is interior, different reaction reagents are then injected according to aforesaid operations according to requirement of experiment, during reaction reagent is vortexed, various reactions
Reagent is sufficiently mixed uniformly with the reactant mixture of magnetic bead reagent composition, and the side wall of lower bin 4 is heated while fluid injection, carries
For the heat needed for reaction, it is to avoid wall built-up phenomenon occur.
When reagent enrichment procedure is carried out, after question response reagent is sufficiently mixed reaction completely, enriching apparatus 6 are arranged on short
On the side wall of lower bin 4 of axle one end, reacted magnetic bead reagent is enriched with enriching apparatus 6, after being enriched with 30~60 seconds, instead
Magnetic bead reagent after answering adsorbs the inner surface of the side wall in lower bin 4 completely, and linearly distributed, and orlop 2 is imbibition position, so
After carrying out slow imbibition until the liquid in bin is suctioned out completely with pipette afterwards, then remove enriching apparatus 6, you can realize magnetic
The enrichment procedure of pearl reagent.
Claims (3)
1. a kind of reaction warehouse for in-vitro diagnosis equipment and with elliptical openings, including top carries retainer plate（1）Storehouse
Body, the warehouse is by bin and the orlop for being arranged on the bin bottom（2）Composition, the bin is by upper bin（3）With lower storehouse
Room（4）Linking is formed, it is characterised in that：The upper bin（3）Upper shed（5）It is ellipsoidal structure, upper bin（3）Side wall
It is from the retainer plate（1）Bottom up bin（3）Taper type structure received in lower open end, up big and down small, it is described
Lower bin（4）Side wall is from lower bin（4）Lower end is to the orlop（2）The up big and down small taper type structure of interior receipts, under
Bin（4）The taper of side wall is more than upper bin（3）The taper of side wall, upper bin（3）Side wall and lower bin（4）Side wall horizontal stroke
Cross section contour is and upper bin（3）Upper shed（5）Shape identical ellipsoidal structure, orlop（2）It is circular arc bottom；Under
Bin（4）Side wall on be provided with enriching apparatus（6）.
2. in-vitro diagnosis equipment and the reaction warehouse with elliptical openings are used for according to claim 1, it is characterised in that：Institute
State upper and lower bin（4）Wall thickness be 0.4~1.0mm.
3. the reaction warehouse for in-vitro diagnosis equipment and with elliptical openings according to claim 1 or claim 2, its feature exists
In：The fluid injection position of the bin is located at the enriching apparatus（6）Lower bin at upper side position（4）Side wall top.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621251585.5U CN206262569U (en) | 2016-11-22 | 2016-11-22 | For in-vitro diagnosis equipment and with elliptical openings reaction warehouse |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621251585.5U CN206262569U (en) | 2016-11-22 | 2016-11-22 | For in-vitro diagnosis equipment and with elliptical openings reaction warehouse |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206262569U true CN206262569U (en) | 2017-06-20 |
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ID=59039843
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621251585.5U Active CN206262569U (en) | 2016-11-22 | 2016-11-22 | For in-vitro diagnosis equipment and with elliptical openings reaction warehouse |
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| CN (1) | CN206262569U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112665944A (en) * | 2020-12-29 | 2021-04-16 | 安图实验仪器(郑州)有限公司 | Reaction bin |
| CN117571437A (en) * | 2023-11-20 | 2024-02-20 | 广州毅昌科技股份有限公司 | Quantitative sample cup-in extraction device |
-
2016
- 2016-11-22 CN CN201621251585.5U patent/CN206262569U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112665944A (en) * | 2020-12-29 | 2021-04-16 | 安图实验仪器(郑州)有限公司 | Reaction bin |
| CN117571437A (en) * | 2023-11-20 | 2024-02-20 | 广州毅昌科技股份有限公司 | Quantitative sample cup-in extraction device |
| CN117571437B (en) * | 2023-11-20 | 2024-06-07 | 广州毅昌科技股份有限公司 | Quantitative sample cup-in extraction device |
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information |
Inventor after: Pan Yang Inventor after: Wang Chao Inventor after: Zhao Peng Inventor after: Wu Hongguang Inventor after: Dong Ji Inventor after: Yang Liuqing Inventor after: Liu Yaoji Inventor after: Liu Cong Inventor before: Pan Yang Inventor before: Wang Chao Inventor before: Zhao Peng Inventor before: Yang Liuqing Inventor before: Liu Yaoji Inventor before: Liu Cong |
|
| CB03 | Change of inventor or designer information |