CN205074084U - Modular small -size desktop formula magnetic separation device of high flux - Google Patents
Modular small -size desktop formula magnetic separation device of high flux Download PDFInfo
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- CN205074084U CN205074084U CN201520459321.8U CN201520459321U CN205074084U CN 205074084 U CN205074084 U CN 205074084U CN 201520459321 U CN201520459321 U CN 201520459321U CN 205074084 U CN205074084 U CN 205074084U
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Abstract
The utility model provides a modular small -size desktop formula magnetic separation device of high flux, includes 96 hole magnetic separation boards, takes 96 orifice plates of V type groove design, V type multichannel loading slot and take the negative pressure suction device of eight claw suction heads. Be equipped with cylindrical permanent magnet array on the micropore grillage, permanent magnet array alignment mode is every micropore left and right sides or a permanent magnet is placed to per two micropores centre, the permanent magnet of every micropore both sides can be with the firm absorption of magnetic particle in the downthehole liquid phase on the lateral wall of neighbouring magnet, the negative pressure suction device of eight claw suction heads is taken in the use, insert the bottom in V type groove of taking 96 orifice plates of V type groove design on the 96 hole magnetic separation grillages of slope design, can siphon away kong zhongwei by absorbent liquid phase composition, the utility model has the advantages of simple structure, the separation effect is very good, easy operation is nimble convenient, need not to prepare the numerous of a large amount of working solutions.
Description
Technical field
The utility model relates to a kind of high-throughput mini desktop magnetic separating device, particularly refer to that a kind of magnetic that utilizes for realizing being separated of magnetic particle and liquid by magnetic field rich magnetic particulate from multiple standards shuttle, unique magnetic region, both sides, sample separation hole is firmly adsorbed and is made magnetic bead loss amount few with V-type groove sample adding device, fluid separation applications is complete, and clean result is good.
A kind of Combined high flux small table formula magnetic separating device, comprise 96 hole Magneto separate plates, 96 orifice plates, band attemperating unit places 96 orifice plate Magneto separate grillages, the microwell plate oscillator of 96 orifice plates, 96 hole Magneto separate grillages, multiple tracks loading slot, and the negative pressure suction device of band eight pawl suction nozzle, it is characterized in that, described 96 orifice bores are V-type designs, and described multiple tracks loading slot is also V-type, and described 96 hole Magneto separate grillages are inclined design.
Background technology
Magneto separate can add sample separation with the nanoscale magnetic bead of sample specific bond, magnetic bead is combined with sample, then be adsorbed under magnetic fields on chamber wall or bar magnet, very simply target sample can be separated with solution system, then with specific elute soln target molecule be eluted in solution from magnetic bead and namely obtain reaction mixture.After first biology enzyme is fixed on the ferric oxide nanometer particle that silica and cellulose embed by the people such as Robinson in 1973, about the preparation of super-paramagnetism nano (or sub-micro level) particle and finishing thereof obtain vigorous growth, current magnetic bead surfaces is amino, the various sense such as carboxyl is modified in conjunction with various biological and chemical molecule, the high-specific surface area that magnetic-particle also has, superparamagnetism, be easy to the advantage of finishing, magnetic separation technique is efficient because having, integrate the various features such as separation and concentration fast and be widely used in immunoassay, nucleic acid extraction, gene sequencing, cell separation, immobilised enzymes, the key areas of the life sciences such as chiral separation.Paramagnetic particle method isolation technics is tending towards extensive and universal in the application of purified biomolecular, cell drug molecule etc.Compared with conventional centrifugal process, ion-exchange, chemical purification, simple, convenient, and non-corrosiveness and toxic agent, safer.
Current equipment for magnetic separation is divided into craft and automation to use.The equipment for magnetic separation that automation uses is suitable for based on 96 orifice plates; Manual operations is based on various centrifuge tube shelf.Major way is embedded in pipe support permanent magnet fixed packet.Most equipment for magnetic separation are only applicable to a kind of centrifuge tube of specification, also have minority pipe support to have employed the Combination Design of applicable several centrifuge tube.But not by the design that various centrifuge tube shelf and 96 orifice plates are integrated, high flux experiment can not be realized and use.
The function of liquor removing workstation generally all integrated by full automatic Magneto separate machine, representative has Thermo, the product of the offshore companies such as Lifetech, Aurora, Bio-Rad, domestic also have some companies to copy, these product basic functions can be divided into bar magnet method and suction method, first talk about suction method, as the term suggests, suction method is undertaken by automatic pipetting device exactly, adds magnetic bead and sample mix liquid, magnetic bead absorption by automatic pipetting device; Take raffinate away, add cleaning solution, magnetic bead adsorbs, and takes cleaning solution away, adds machine (detection of Luminex multiple-factor) on elution buffer biochemical molecule extractings such as () RNA or upper machine buffer solution.As having no problem step, but the maximum problem of suction method is, in order to not take magnetic bead away when removal waste liquid, tap can not lean on magnetic bead too near, in case magnetic bead is taken out together with waste liquid, sub-fraction is always had not take away thoroughly when taking out waste liquid so each time, particularly magnet is at the device of bottom, because magnetic bead by magnet adsorption in bottom, so tap can not lean on bottom too near, such liquid just can not be removed completely, residual liquid can affect reaction below, the liquid that the device of magnet in side remains can be less, but certainly there is a circle liquid residue around hole, automatic operation station working procedure is slow, some 96 automatic nucleic acid extraction work station, a time of taking turns of extracting needs 150 minutes, the same time of 32 bar magnet methods can be carried 5 and take turns.
Besides bar magnet method instrument for extracting nucleic acid, flux has 8 usually, 16, 32, 96 passages, relative to suction method, the advantage of bar magnet method is that the liquid that each walks does not remain, because bar magnet only takes away magnetic bead, to transfer in the corresponding reacting hole of next step. the flux of bar magnet method selects preferably 32 passages, 96 passages to seem flux higher, but there is a very real problem, 96 magnetic bars are when being transferred to another one plate from a plate, what if liquid midway above magnetic bar drips down, it can drip in other hole and pollute, and the magnetic bar running orbit of 32 passages is without the overhead of other samples, but after all bar magnet gos deep in hole, be easy to pollute, also must buy the consumptive material of bar magnet overcoat, expensive, the well-to-do not laboratory of funds can not adopt usually.
Flourish at present along with Luminex multiple-factor detection technique, on magnetic bead can coupled antibody for detecting target protein, can coupling DNA, RNA, MiRNA, the probe of the correspondence such as transcription factor is for detecting these target molecules, representative has the Mili-plex antibody chip of Bio-plex and Millipore of Bio-Rad, the antibody chip of Affymetrix, with Quantigeneplex gene expression detection platform, these experiment prices are very expensive, one piece of 96 orifice plate reacts ten of thousands unit easily, reagent working solution is of great rarity, when doing the experiment of these magnetic beads, generally can not with the automatic operation station needing large volume working solution. also have the very important point, the Quantigeneplex gene expression detection platform of Affymetrix, reactant liquor wherein and cleaning solution all very sticky, with manual and these automatic operation stations above, all very difficult wash clean.
Therefore, a kind of integration is designed, high flux, operate flexibly and easily again, liquid in hole can be blotted, save reagent, the Magneto separate rack device of difference between reduce orifice, to meet the Magneto separate requirement that scientific research and medium and small laboratory often change, is technical problem to be solved in the utility model.
Utility model content
The utility model is for above-mentioned technological deficiency, and provide integration, high flux, operates again flexibly and easily, can blot liquid in hole, saves reagent, the magnetic separating device of difference between reduce orifice.This device overcomes many deficiencies that existing large automatic magnetic separating device exists, or this low, simple structure, good separating effect, processing ease.
The utility model object is to provide a kind of Combined high flux small table formula magnetic separating device, comprise 96 hole Magneto separate plates, with 96 orifice plates of V-type groove design, the microwell plate oscillator of 96 orifice plate Magneto separate grillages and 96 orifice plates is placed with attemperating unit, 96 hole Magneto separate grillages of inclined design, the V-type multiple tracks loading slot of 96 hole sizes, with the negative pressure suction device of band eight pawl suction nozzle. micropore grillage is provided with cylindrical magnet iron array, be of a size of standard 96 well culture plate, permanent magnet arrayed mode is that each micropore left and right sides respectively has a column type permanent magnet, when applying this device and being separated the magnetic-particle in microwell plate, magnetic-particle in liquid phase in hole is reunited and is firmly adsorbed on the left and right sides wall of micropore by the column type permanent magnet of each micropore both sides, use the negative pressure suction device of band eight pawl suction nozzle, insert the V-type groove lowermost end of 96 orifice plates of the band V-type groove design on 96 hole Magneto separate grillages of inclined design, can almost noresidue siphon away Kong Zhongwei by the liquid phase ingredient adsorbed, it is simple that the utility model has structure, separating effect is very good, flexibly and easily simple to operate, without the need to preparing the many merits of extensive work liquid.
Further, the magnetic material of 96 described hole Magneto separate plates is Ru-Fe-Mn, a kind of magnetic material in permanent ferrite, soft magnetic ferrite, SmCo is made, or use electromagnet. Magneto separate plate base plate foreign minister 138.4 ± 1mm, wide 96.6 ± 1mm outward, indent flute length 128.4 ± 1mm, wide 86.6 ± 1mm, column type permanent magnet and magnet groove diameter 5.4 ± 1mm, each magnetic blow out centre point is at a distance of 9 ± 1mm, first row magnet array distance inner groovy left side wall 14.7 ± 1mm, distance upper side wall 7.3 ± 1mm.
Further, described Combined high flux small table formula magnetic separating device, it is characterized in that 96 orifice plates of described V-type groove design, outside dimension is consistent with common 96 orifice plates, inside is divided into 96 square holes with the wall thickness of 0.8 ± 0.5mm, is the V-type translot of V-type angle 120-170 degree on the right side of each square hole.
Further, 96 orifice plates of described V-type groove design, outside dimension is consistent with common 96 orifice plates, and inside is divided into 96 square holes with the wall thickness of 0.8 ± 0.5mm, is the V-type translot of V-type angle 120-170 degree on the right side of each square hole.
Further, described 96 hole Magneto separate plates can place 96 orifice plates of general standard on the market, 96 hole depth orifice plates, and 96 orifice plates of band V-type groove according to claim 1 design, all size plate is placed into after on 96 hole Magneto separate plates, and the left and right sides, hole is respectively to Ying Youyige magnetic-adsorption district.
Further, 96 Magneto separate grillage angles of inclination, hole of described inclined design are 15-45 degree, 96 orifice plates with the design of V-type groove can be placed on 96 hole Magneto separate grillages of inclined design, almost can blot liquid in hole completely with the negative pressure suction device of band eight pawl suction nozzle in 96 orifice plates deeply with the design of V-type groove.
Further, the V-type multiple tracks loading slot material of 96 described hole sizes can be stainless steel, resin, ABS, PLA plastics
According to separator of the present utility model, described 96 hole Beads enrichment plate structure standardization level are high, and 96 hole corresponding magnetic post position deviations are little, and simple structure is easy-to-use, and common lab can be used.And this magnetic bead separating device is easy to use, structure is simple, cleans very clean.This device hand-held uses, and the volume for wash-out final during biological sample purification can be low to moderate 15UL, and the minimum 50ul of volume requirement of the final wash-out in automatic operation station, and the suction of automatic operation station is not done, and leaves raffinate.This device is applicable to various biology or the medical laboratory large molecule for difference amount and the Beads enrichment application of cell.
Except object described above, feature and advantage, the other objects, features and advantages that the utility model has, will be described in further detail by reference to the accompanying drawings.
Accompanying drawing explanation
Accompanying drawing forms the part of this description, for understanding the utility model further.Shown in the drawings of preferred embodiment of the present utility model, and be used for principle of the present utility model is described together with description.In figure:
Fig. 1 is the schematic diagram of the Magneto separate plate being applicable to 96 hole microwell plates;
Fig. 2 is the schematic diagram of 96 square hole plates of V-type groove design;
Fig. 3 is V-type multiple tracks loading slot schematic diagram;
Fig. 4 is eight pawl suction tube device schematic diagrames;
Detailed description of the invention
Below in conjunction with accompanying drawing, embodiment of the present utility model is described in detail, but the multitude of different ways that the utility model can be defined by the claims and cover is implemented.
The Magneto separate plate of 96 hole microwell plates is see Fig. 1: outside (1) 96 Magneto separate plate inner groovy (2) column type magnetic post (3) 96 hole, hole Magneto separate plate inner groovy.
View is with further reference to Fig. 2: 96 orifice plate side views of 96 orifice plate sectional view (7) band V-type groove designs of 96 orifice plate V-type groove schematic diagram (6) band V-type groove designs of 96 orifice plate top view (5) band V-type groove designs of (4) band V-type groove design.
View is with further reference to Fig. 3: (8) V-type multiple tracks loading slot minimum loading slot (9) V-type multiple tracks loading slot medium-sized loading slot (10) V-type multiple tracks loading slot maximum loading slot (11) V-type multiple tracks loading slot pedestal.
View is with further reference to Fig. 4: (12) eight pawl suction pipe front view (13) eight pawl suction pipe top view (14) eight pawl suction pipe side view (15) eight pawl suction pipe 45 degree of sides.
1.96 hole Magneto separate plate inner groovies
2. column type magnetic post
Outside 3.96 hole Magneto separate plate inner groovies
4. be with 96 orifice plate top views of V-type groove design
5. be with 96 orifice plate V-type groove schematic diagrames of V-type groove design
6. be with 96 orifice plate sectional views of V-type groove design
7. be with 96 orifice plate side views of V-type groove design
The minimum loading slot of 8.V type multiple tracks loading slot
The medium-sized loading slot of 9.V type multiple tracks loading slot
The maximum loading slot of 10.V type multiple tracks loading slot
11.V type multiple tracks loading slot pedestal
12. 8 pawl suction pipe front views
13. 8 pawl suction pipe top views
14. 8 pawl suction pipe side views
15. 8 45 degree, pawl suction pipe sides
According to separator of the present utility model, described Combined high flux small size magnetic separator reduces greatly than the full-automatic instrument price of selling on the market, cost-saving, and common lab can be used.And this magnetic bead separating device is easy to use, structure is simple, cleans very clean.This device hand-held uses, and the volume of final wash-out can be low to moderate 15UL, and the minimum 50ul of volume requirement of the final wash-out in automatic operation station, and the suction of automatic operation station is not done, and leaves raffinate.This device is applicable to various biology or the medical laboratory biomolecule for difference amount and the Beads enrichment application of cell.
The foregoing is only the preferred embodiment of utility model, be not limited to the utility model, for a person skilled in the art, the utility model can have various modifications and variations.All within spirit of the present utility model and principle, any amendment done, equivalent replacement, improvement etc., within the protection domain that all should be included in utility model.
Claims (5)
1. a Combined high flux small table formula magnetic separating device, comprise 96 hole Magneto separate plates, 96 orifice plates, band attemperating unit places 96 orifice plate Magneto separate grillages, the microwell plate oscillator of 96 orifice plates, 96 hole Magneto separate grillages, multiple tracks loading slot, and the negative pressure suction device of band eight pawl suction nozzle, it is characterized in that, the groove of described 96 orifice plates is V-type designs, and described multiple tracks loading slot is also V-type, and described 96 hole Magneto separate grillages are inclined design.
2. a Combined high flux small table formula magnetic separating device as claimed in claim 1, it is characterized in that, the magnetic material of 96 described hole Magneto separate plates is Ru-Fe-Mn, permanent ferrite, soft magnetic ferrite, a kind of magnetic material in SmCo is made, or use electromagnet, Magneto separate plate base plate foreign minister 138.4 ± 1mm, wide 96.6 ± 1mm outward, indent flute length 128.4 ± 1mm, wide 86.6 ± 1mm, column type permanent magnet and magnet groove diameter 5.4 ± 1mm, each magnetic blow out centre point is at a distance of 9 ± 1mm, first row magnet array distance inner groovy left side wall 14.7 ± 1mm, distance upper side wall 7.3 ± 1mm.
3. a Combined high flux small table formula magnetic separating device as claimed in claim 1, it is characterized in that, 96 orifice plates of described V-type groove design, long 128.4 ± the 1mm of outside dimension, wide 86.6 ± 1mm, inside is divided into 96 square holes with the wall thickness of 0.8 ± 0.5mm, is the V-type translot of V-type angle 120-170 degree on the right side of each square hole.
4. a Combined high flux small table formula magnetic separating device as claimed in claim 1, is characterized in that 96 orifice plates of band V-type groove as claimed in claim 1 design placed by 96 described hole Magneto separate plates.
5. a Combined high flux small table formula magnetic separating device as claimed in claim 1, it is characterized in that, 96 Magneto separate grillage angles of inclination, hole of described inclined design are 15-45 degree, 96 orifice plates with the design of V-type groove are placed on 96 hole Magneto separate grillages of inclined design, draw liquid in hole with in 96 orifice plates deeply with the design of V-type groove of the negative pressure suction device of band eight pawl suction nozzle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520459321.8U CN205074084U (en) | 2015-06-30 | 2015-06-30 | Modular small -size desktop formula magnetic separation device of high flux |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520459321.8U CN205074084U (en) | 2015-06-30 | 2015-06-30 | Modular small -size desktop formula magnetic separation device of high flux |
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| Publication Number | Publication Date |
|---|---|
| CN205074084U true CN205074084U (en) | 2016-03-09 |
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|---|---|---|---|
| CN201520459321.8U Active CN205074084U (en) | 2015-06-30 | 2015-06-30 | Modular small -size desktop formula magnetic separation device of high flux |
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| CN (1) | CN205074084U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108660216A (en) * | 2018-05-16 | 2018-10-16 | 中国人民解放军陆军军医大学第附属医院 | Kit and its detection method based on peripheral blood free nucleotide miRNAs super sensitivity detection devices |
| CN112980648A (en) * | 2021-02-26 | 2021-06-18 | 浙江大学 | High-flux magnetic bead rapid transfer device |
-
2015
- 2015-06-30 CN CN201520459321.8U patent/CN205074084U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108660216A (en) * | 2018-05-16 | 2018-10-16 | 中国人民解放军陆军军医大学第附属医院 | Kit and its detection method based on peripheral blood free nucleotide miRNAs super sensitivity detection devices |
| CN112980648A (en) * | 2021-02-26 | 2021-06-18 | 浙江大学 | High-flux magnetic bead rapid transfer device |
| CN112980648B (en) * | 2021-02-26 | 2023-02-28 | 浙江大学 | High-flux magnetic bead rapid transfer device |
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| TR01 | Transfer of patent right |
Effective date of registration: 20231121 Address after: Room 702, Exhibition Center Building, No. 505 Zhangjiang Road, Pudong New Area, Shanghai, 2012 Patentee after: Shanghai Tuobao Mai Biotechnology Co.,Ltd. Address before: Room 402, No. 23, Lane 478, Fanghua Road, Pudong, Shanghai, 201200 Patentee before: Wang Lili |
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