CN206157177U - Be used for active test kit of liver medicine enzyme inhibitor - Google Patents
Be used for active test kit of liver medicine enzyme inhibitor Download PDFInfo
- Publication number
- CN206157177U CN206157177U CN201621196093.0U CN201621196093U CN206157177U CN 206157177 U CN206157177 U CN 206157177U CN 201621196093 U CN201621196093 U CN 201621196093U CN 206157177 U CN206157177 U CN 206157177U
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- cylindrical body
- enzyme inhibitor
- test kit
- hole
- liver
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The utility model provides a be used for active test kit of liver medicine enzyme inhibitor, it relates to an enzymatic activity test kit. The shape of current kit is unfavorable for cooperating other equipment to realize detection achievement, at the in -process that utilizes liver medicine enzyme inhibitor to the active test of liver drug metabolizing enzyme, can't realize in time contrasting effectively to detect leading to active test result unreliable because of the enzyme solution strength, and liver drug metabolizing enzyme and the reaction time of liver medicine enzyme inhibitor in reaction sequence can't contrast effectively in the realization simultaneously. Concentration tester in this product sets up on cylindrical body, and processing has and observes the hole of placing that the hole is linked together with survey on the cylindrical body, places the downthehole reaction that is equipped with, and the up end of cylindrical body still is provided with a plurality of time -recorders, and every time -recorder is close to its jack setting that corresponds, and every jack interpolation is equipped with a test tube, the up end of cylindrical body still in proper order processing have test paper standing groove and egg white standing groove. This product is arranged in liver medicine enzyme activity test procedure.
Description
Technical field
This utility model is related to a kind of enzymatic activity test kit, belongs to medical equipment technical field.
Background technology
Drug metabolizing enzyme is a kind of important metabolic enzyme in animal body, is substantially Jing liver drug enzyme metabolism into sanguimotor medicine
, liver drug enzyme is one kind of drug metabolizing enzyme, and liver drug enzyme is to carry out bioconversion in liver in most drug, because there are in hepatocyte
The enzyme system of microsome mixed function, and the system can promote multi-medicament to convert, the bioconversion of minority medicine is to lean on
The catalysis of non-particulate body enzyme, the acetylcholine esterase in monoamine oxidase, MAO and blood plasma such as in mitochondrion.It is influential on liver drug enzyme
Medicine, also influences whether the metabolism of medicine.The medicine for wherein making liver drug enzyme increased activity claims liver microsomalinducer.Liver drug enzyme is set to live
Property weaken medicine claim microsomal enzyme inhibitor.Liver drug enzyme is to the reaction of liver microsomalinducer and microsomal enzyme inhibitor to liver drug enzyme
Use there is directive significance.Testing crew finds that the shape of available reagent box mostly is rectangular box or folding in actual tests
Formula plate body, such structure is unfavorable for coordinating microscope or other equipment to realize detection work, using microsomal enzyme inhibitor pair
During liver drug enzyme active testing, because enzymatic solution concentration cannot realize that timely and effectively comparison and detection causes active testing result
It is unreliable, while the liver drug enzyme and microsomal enzyme inhibitor response time during the course of the reaction cannot be realized effectively contrasting, cause
Time factor is uncontrollable in detection process, needs to expend larger manpower realization work in time, has a strong impact on the work of testing crew
Efficiency.
The content of the invention
The purpose of this utility model is to provide one kind for microsomal enzyme inhibitor active testing test kit, to solve existing examination
The shape of agent box be unfavorable for coordinate other equipment realize detection work, using microsomal enzyme inhibitor to liver drug enzyme active testing
During, because enzymatic solution concentration cannot realize that timely and effectively comparison and detection causes active testing result unreliable, while liver medicine
The enzyme and microsomal enzyme inhibitor response time during the course of the reaction cannot realize the problem for effectively contrasting.
This utility model is adopted the technical scheme that to solve above-mentioned technical problem：
One kind is used for microsomal enzyme inhibitor active testing test kit, including cylindrical body, concentration tester, reagent paper are placed
Groove, Ovum Gallus domesticus album placing trough and multiple timers, the cylindrical body is horizontally disposed with, and the concentration tester is vertically arranged in cylinder
On shape body, at least one measure observation port and multiple jacks, the cylinder are machined with the upper surface of the cylindrical body
It is machined with the outer circumferential end face of shape body and determines the putting hole that observation port is connected, reactive tank is provided with putting hole, circle
The upper surface of cylindrical body is additionally provided with multiple timers, and timer is corresponded with jack and arranged, and each timer is near it
Corresponding jack is arranged, and a test tube is inserted with each jack, and the upper surface of cylindrical body is also machined with successively reagent paper and puts
Groove and Ovum Gallus domesticus album placing trough are put, several test papers are provided with reagent paper placing trough, in the Ovum Gallus domesticus album placing trough Ovum Gallus domesticus album is provided with
Liquid.
This utility model has the advantages that：
1st, this product can realize Through Several Survey Measure, by concentration tester, reagent paper placing trough and Ovum Gallus domesticus album placing trough
The liver drug enzyme activity after three kinds of different detection modes are realized to reacting between liver drug enzyme and microsomal enzyme inhibitor respectively is set
Detection, flexibly, detection range is comprehensive, it is adaptable to different types of microsomal enzyme inhibitor for detection mode, can be conveniently and quick
Test out microsomal enzyme inhibitor to liver drug enzyme activity impact.
2nd, at least one measure observation port and multiple jacks are that liver drug enzyme and liver drug enzyme are suppressed for convenience in this product
Course of reaction provides reaction compartment and observation space between agent, and multiple jacks match with multiple test tubes and are combined into liver drug enzyme and liver medicine
Reaction between enzyme inhibitor provides reaction compartment, determine observation port, cooperate between putting hole and reactive tank for liver drug enzyme with
Reaction between microsomal enzyme inhibitor provides observation space, at the same the position determined between observation port and putting hole arrange be easy to it is micro-
Mirror is observed.
3rd, cooperate the flexible of the effectively timing of enhancing this product in this product between multiple jacks and multiple timers
Property, when the setting of multiple timers can either record the reaction of one group of active testing between liver drug enzyme and microsomal enzyme inhibitor
Between, also dependent on needing to carry out multigroup liver drug enzyme and microsomal enzyme inhibitor timing simultaneously, timing time is independent and can realize
It is compared, opens timing by manual control, motility is strong, effectively saves manpower timing, time saving and energy saving, is conducive to improving test
The work efficiency of personnel.
4th, this product can realize same microsomal enzyme inhibitor to variable concentrations liver drug enzyme solution within the same time
Activity determination works, additionally it is possible to realize work of the microsomal enzyme inhibitor not of the same race to same concentrations liver drug enzyme solution within the same time
Property detection work, additionally it is possible to realize Activity determination work of the same liver drug enzyme to same concentration liver drug enzyme solution in different time
Make.
Description of the drawings
Fig. 1 illustrates the front view structure figure of this product；
Fig. 2 illustrates the structure of annexation between putting hole 6, reactive tank 7, concentration tester 2 and cylindrical body 1
Figure；
Fig. 3 illustrates the working state schematic representation of this product, and 10, measure observation port 4 of a test tube is only shown in figure
With a putting hole 6, reactive tank 7 is removed in figure.
Specific embodiment
Below in conjunction with accompanying drawing, the utility model is described in further detail
Specific embodiment one：Present embodiment is illustrated with reference to Fig. 1, Fig. 2 and Fig. 3, present embodiment includes cylinder originally
Body 1, concentration tester 2, reagent paper placing trough 8, Ovum Gallus domesticus album placing trough 9 and multiple timers 3, the cylindrical body 1 is horizontally disposed with,
The concentration tester 2 is vertically arranged on cylindrical body 1, and at least one is machined with the upper surface of the cylindrical body 1
Individual measure observation port 4 and multiple jacks 5, are machined with the outer circumferential end face of the cylindrical body 1 and are connected with measure observation port 4
Reactive tank 7 is provided with logical putting hole 6, putting hole 6, the upper surface of cylindrical body 1 is additionally provided with multiple timers 3, meter
When device 3 and jack 5 correspond and arrange, each timer 3 is arranged near its corresponding jack 5, and in each jack 5 one is inserted with
Individual test tube 10, the upper surface of cylindrical body 1 is also machined with successively reagent paper placing trough 8 and Ovum Gallus domesticus album placing trough 9, reagent paper placing trough 8
In be provided with several test papers, be provided with egg white solution in the Ovum Gallus domesticus album placing trough 9.
Concentration tester 2 is existing small-sized enzyme concentration tester in present embodiment, and it is the product that market is commercially available
Product.
It is circular hole or square hole that observation port 4 is determined in present embodiment, and jack 5 is circular hole, can be changed jack 5 as needed
Make and be processed as determining observation port 4.
Specific embodiment two：Present embodiment, radial direction of the multiple jacks 5 along cylindrical body 1 are illustrated with reference to Fig. 3
It is evenly arranged on the upper surface of cylindrical body 1.
The position of multiple jacks 5 is reasonable and separate, is rationally laid out using the shape of cylindrical body 1,
Be conducive to coordinating other equipment further to be detected work in subsequent step, while also allowing for taking for test tube 10.Test tube
10 is small-sized short tube, is easy to follow-up microscopical observation, and it is highly the three times of the thickness of cylindrical body 1 to four times.
Specific embodiment three：Present embodiment is illustrated with reference to Fig. 1, Fig. 2 and Fig. 3, jack 5 is through hole or blind hole.
When jack 5 is through hole, the corresponding test tube 10 of the jack 5 passes through the jack 5, can realize the effectively fixed of test tube 10
Position；When jack 5 is blind hole, the corresponding test tube 10 of the jack 5 is located in the jack 5, and the ttom of pipe of test tube 10 is flat tube bottom,
Be conducive to being fitted with the bottom hole of blind hole.
Specific embodiment four：Present embodiment is the further restriction of specific embodiment three, and concentration tester 2 is along circle
The axial direction of cylindrical body 1 passes through cylindrical body 1, and detachable once property is surveyed at the test lead of the concentration tester 2
Test glass.It is measured according to the particular location of the test lead of concentration tester 2, when concentration tester 2 is along the axle of cylindrical body 1
When passing through cylindrical body 1 to direction, disposable test cup is arranged on the lower surface of cylindrical body 1 and it is disposable design
It is in order to avoid interfering between variety classes, the liver drug enzyme solution of variable concentrations, being divided into respective independent detection.Concentration is surveyed
The top of examination instrument 2 is machined with anti-slip veins.
Specific embodiment five：Present embodiment is the further restriction of specific embodiment one, determines the individual of observation port 4
Number is 1 to 3.The measure observation port 4 for selecting varying number is determined according to actual tests task and the workload of test.
Specific embodiment six：Present embodiment is illustrated with reference to Fig. 1, Fig. 2 and Fig. 3, when the number for determining observation port 4 is more than
Or during equal to 2, each determines observation port 4 pairs should a putting hole 6, and in each putting hole 6 reactive tank 7 is provided with.
Specific embodiment seven：Present embodiment is illustrated with reference to Fig. 1, Fig. 2 and Fig. 3, the bottom of cylindrical body 1 is provided with
Base.Base is conducive to strengthening the stability of cylindrical body 1, and the two is detachably connected.
Specific embodiment eight：Present embodiment is illustrated with reference to Fig. 1, on each timer 3 timing warner is provided with.It is fixed
Alarm device includes buzzer, and timing warner is existing procucts, for the timework of ancillary test personnel, belongs to predetermined
Start countdown after response time, buzzer starts the stopped reaction test of prompting testing crew after to the scheduled time, to anti-
The activity of the liver drug enzyme after answering is detected.
The course of work：
Activity determination process of the same microsomal enzyme inhibitor to variable concentrations liver drug enzyme solution within the same time：
Multiple test tubes 10 are taken out, the liver drug enzyme solution of various concentration is made, using concentration tester 2 each is tried successively
The concentration of the liver drug enzyme solution in pipe 10 is measured, and concentration value is recorded successively, and multiple test tubes 10 are sequentially placed into into cylinder originally
In multiple jacks 5 of the upper surface of body 1, the microsomal enzyme inhibitor of same equivalent is sequentially added, the duration such as predetermined is separately turned on many
The corresponding multiple timers 3 of individual jack 5, it is ensured that microsomal enzyme inhibitor is added and open after a test tube 10 timer 3, is arrived
After the scheduled time, the change of each test tube 10 is observed, multiple reagent paper taken out in reagent paper placing trough 8 are sequentially placed into multiple test tubes 10
In, the activated state of liver drug enzyme solution in multiple test tubes 10 is determined respectively according to standard color comparison card contrast, it is further when needing
The liver drug enzyme solution of observation, using dropper a certain amount of solution is taken out, and is injected in the interior reactive tank 7 in putting hole, by surveying
Determine observation port 4 directly to be observed or carry out microscopic observation to the solution change determined in observation port 4 using microscope, when passing through
During the DeGrain that standard color comparison card cannot be contrasted, the Ovum Gallus domesticus album taken out in Ovum Gallus domesticus album placing trough 9 is directly placed in test tube 10
Row observation.Record result is in case follow-up study.
Activity determination process of the microsomal enzyme inhibitor not of the same race to same concentrations liver drug enzyme solution within the same time：
Multiple test tubes 10 are taken out, the liver drug enzyme solution for making same concentration is fixed toward injection in multiple test tubes 10 is injected respectively
The liver drug enzyme solution of amount, is measured using the concentration of the liver drug enzyme solution in test tube 10 of concentration tester 2 pair, records dense
Angle value, multiple test tubes 10 are sequentially placed in multiple jacks 5 of the upper surface of cylindrical body 1, sequentially add the not of the same race of equivalent
The microsomal enzyme inhibitor of class, it is predetermined to wait duration to be separately turned on the corresponding multiple timers 3 of multiple jacks 5, it is ensured that liver drug enzyme suppresses
Agent is added and open after a test tube 10 timer 3, to after the scheduled time, observes the change of each test tube 10, takes out examination
Multiple reagent paper in paper placing trough 8 are sequentially placed in multiple test tubes 10, and according to standard color comparison card contrast multiple examinations are determined respectively
The activated state of liver drug enzyme solution in pipe 10, when the DeGrain that cannot be contrasted by standard color comparison card, takes out Ovum Gallus domesticus album
Ovum Gallus domesticus album in placing trough 9 is directly placed in test tube 10 and is observed.Record result is in case follow-up study.
For Activity determination work of the microsomal enzyme inhibitor not of the same race to same concentrations liver drug enzyme solution in different time
Operation principle and microsomal enzyme inhibitor of the same race to variable concentrations liver drug enzyme solution in different time Activity determination work
Operation principle ibid.
Claims (8)
- It is 1. a kind of to be used for microsomal enzyme inhibitor active testing test kit, it is characterised in that：Including cylindrical body（1）, concentration survey Examination instrument（2）, reagent paper placing trough（8）, Ovum Gallus domesticus album placing trough（9）, multiple test tubes（10）With multiple timers（3）, the cylinder is originally Body（1）It is horizontally disposed, the concentration tester（2）It is vertically arranged in cylindrical body（1）On, the cylindrical body（1）'s At least one measure observation port is machined with upper surface（4）With multiple jacks（5）, the cylindrical body（1）Excircle end It is machined with face and determines observation port（4）The putting hole being connected（6）, putting hole（6）Inside it is provided with reactive tank（7）, cylinder Body（1）Upper surface be additionally provided with multiple timers（3）, timer（3）With jack（5）Correspond and arrange, each timing Device（3）Near its corresponding jack（5）Arrange, each jack（5）Inside it is inserted with a test tube（10）, cylindrical body（1）'s Upper surface is also machined with successively reagent paper placing trough（8）With Ovum Gallus domesticus album placing trough（9）, reagent paper placing trough（8）In be provided with several survey Have a try paper, the Ovum Gallus domesticus album placing trough（9）In be provided with egg white solution.
- 2. according to claim 1 a kind of for microsomal enzyme inhibitor active testing test kit, it is characterised in that：It is multiple to insert Hole（5）Along cylindrical body（1）Radial direction be evenly arranged in cylindrical body（1）Upper surface on.
- 3. according to claim 1 and 2 a kind of for microsomal enzyme inhibitor active testing test kit, it is characterised in that：Insert Hole（5）For through hole or blind hole.
- 4. according to claim 3 a kind of for microsomal enzyme inhibitor active testing test kit, it is characterised in that：Concentration is surveyed Examination instrument（2）Along cylindrical body（1）Axial direction pass through cylindrical body（1）, the concentration tester（2）Test lead at Detachable once property test cup.
- 5. according to claim 1 a kind of for microsomal enzyme inhibitor active testing test kit, it is characterised in that：Determine and see Examine hole（4）Number be 1 to 3.
- It is 6. a kind of according to claim 1 or 5 to be used for microsomal enzyme inhibitor active testing test kit, it is characterised in that：When Determine observation port（4）Number be more than or equal to 2 when, each determine observation port（4）To there is a putting hole（6）, each Putting hole（6）Inside it is provided with a reactive tank（7）.
- 7. according to claim 1 a kind of for microsomal enzyme inhibitor active testing test kit, it is characterised in that：Cylinder Body（1）Bottom be provided with base.
- 8. according to claim 1 a kind of for microsomal enzyme inhibitor active testing test kit, it is characterised in that：Each meter When device（3）On be provided with timing warner.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621196093.0U CN206157177U (en) | 2016-11-07 | 2016-11-07 | Be used for active test kit of liver medicine enzyme inhibitor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621196093.0U CN206157177U (en) | 2016-11-07 | 2016-11-07 | Be used for active test kit of liver medicine enzyme inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206157177U true CN206157177U (en) | 2017-05-10 |
Family
ID=58656783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621196093.0U Expired - Fee Related CN206157177U (en) | 2016-11-07 | 2016-11-07 | Be used for active test kit of liver medicine enzyme inhibitor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206157177U (en) |
-
2016
- 2016-11-07 CN CN201621196093.0U patent/CN206157177U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170510 Termination date: 20171107 |