A kind of biological specimen automatic access equipment
Technical field
The utility model is related to biological specimen freezer storage equipment, in particular to a kind of biological specimen automatic access
Equipment.
Background technology
Existing biological sample bank is primarily referred to as standardization and collects, processes, stores and answer also known as biobank (Biobank)
With health and the large biological molecule of disease organism, cell, tissue and organ equal samples, including human organ tissue, whole blood, blood
Biological specimen (DNA, RNA, albumen etc.) that slurry, serum, biological fluid or Jing were processed and related to these biological specimens
The data such as clinic, pathology, treatment, follow-up, informed consent and its quality control, information management and application system.
The long term storage of biological specimen is usually used alap temperature to reduce the biochemical reaction in sample, improves sample
The stability of various composition in this, temperature is lower, and the holding time of sample is longer.Typically freeze-stored cell is placed in test tube, examination
Pipe is placed in storage rack, is integrally placed in liquid nitrogen by storage rack, to realize the preservation steady in a long-term of sample.But sample is stored in
Be intended to integrally take out storage rack from nitrogen storage tank when taking out, access is inconvenient, and so extracts every time and all can make
The biological specimen that wouldn't be used into same storage rack also will enter room temperature environment from -150 DEG C of low temperature environment, because of violent temperature
Degree changes and affects its activity and quality;The inside of biological gene sample access arrangement can not quickly and accurately recognize gene sample
This test tube, so as to when gripping to gene test tube, success rate is relatively low and the gripping degree of accuracy is relatively low, not enough reaches from base
Because quickly and accurately being taken out in Sample Storehouse or depositing cdna sample, it is unfavorable for biological gene sample freezer storage industry
It is fast-developing.
Utility model content
The purpose of this utility model is to provide a kind of biological specimen automatic access equipment, to solve prior art in access
Inconvenience, need overall taking-up and affect other biological sample activity and access storehouse to cdna sample pick and place the degree of accuracy and efficiency compared with
Low problem.
To realize the utility model purpose, the technical scheme for adopting for:A kind of biological specimen automatic access equipment, its feature
It is, including frozen tank, the extraction bin above frozen tank, the sample storage rack in frozen tank and extraction bin
The access storehouse of connection and the specimen discerning system inside access storehouse, the sample storage rack is frozen including being rotatably arranged on
Multiple hoisting frames on chassis and chassis in tank, are placed with multilayered memory box on hoisting frame, hoisting frame is equipped with lifting device;
It is provided with the access storehouse to the bracket for extracting bin slip setting, support the storage box;It is provided with access storehouse positioned at bracket top
Clamp device, clamp device be equipped with drive its movement drive mechanism;Access orlop offers thief hole, and thief hole is provided with
Closure, closure is equipped with headstock gear, and closure lower section is provided with sample transporter.
Further, the plurality of hoisting frame is circumferentially distributed along chassis, and each hoisting frame is provided with lifting grab;The frozen tank
Cover is provided with, cover is divided into fixed plate, access riser and maintenance riser, and access riser and maintenance riser lower end are equal
It is provided with correspondence and is lifting the suspension hook below grab.
Further, be provided with vertical demarcation strip in the extraction bin, and by divides into lifted access section,
Maintenance lifting zone;The bin diapire for lifting access section offers access lifting mouth, and the bin diapire for keeping in repair lifting zone offers dimension
Repair lifting mouth;The bin side wall for lifting access section is provided with access door, and the bin side wall for keeping in repair lifting zone is provided with AD.
Further, lifting device include respectively with access riser and keep in repair the access hoisting mechanism that is connected of riser and
Maintenance hoisting mechanism.
Further, the specimen discerning system include being located at the video camera in access silo roof portion, positioned at feeding head motion rail
Two-dimentional code reader and cyclelog on mark, the video camera, two-dimentional code reader and drive mechanism are and cyclelog
Electrical connection.
Further, the power set that the bracket is provided with the storage box location structure and drives bracket to slide, positioning knot
Structure includes being located at the alignment pin of the storage box bottom surface and is arranged on bracket the location hole matched with alignment pin.
Further, the clamp device is provided with feeding head.
Further, feeding head is including sleeve, the rotation pressure head set gradually in sleeve and liftout pipe and positioned at top
Feeding bar in expects pipe, the liftout pipe slides axially setting in sleeve;Described one end for rotating pressure head is set to drive connection
End, the end face of the other end has pressure head cammed surface;One end of the liftout pipe has oblique with the expects pipe that pressure head cammed surface matches
Wedge surface, the other end stretches out sleeve;Described feeding bar one end is connected to rotation pressure head, and the other end stretches out liftout pipe;The liftout pipe
Back-moving spring is provided between sleeve;The drive connection end for rotating pressure head is connected with connector, and connector is connected with motor.
Further, the clamp device also includes fixing body, and the upper end of the feeding head is to be engaged by clamping with fixing body
Fixing body connection end;Access is provided with bearing support in storehouse.The outer wall of feeding head is provided with placement annular groove, bearing support have it is multiple with put
Put the gap that annular groove is adapted.
Further, the sample extraction device includes being slideably positioned in the slide plate below access storehouse, is placed with slide plate
The transferring barrel corresponding with thief hole, transferring barrel is equipped with the staving elevating mechanism for driving its lifting;Erect the end of the slide plate
Directly it is provided with hermatic door.
Had the advantage that using the utility model:
1., by the rotation on chassis, access lifts mouth or maintenance is lifted at mouth to go to be fetched hoisting frame, is lifted
Also corresponding sports, to access riser or the suspension hook top of maintenance riser, lift access riser or maintenance to the grab that lifted of frame
While riser opens frozen tank, the storage box that layer for also hoisting frame being promoted into that sample to be extracted is located, you can Jing
The automatic taking-out mechanism of equipment takes out the storage box or by manually taking out, and is then lifted out frame and declines return, frozen potting again
Close, access very convenient, and to avoid extract every time and be required for taking out on global storage frame, it is to avoid in same storage rack its
Allogene sample undergoes violent temperature change, and the stability of various composition in sample is ensure that well, it is ensured that biological sample
This activity and quality, the holding time of biological specimen is long;
2. biological gene sample access storehouse first passes through the video camera at top and carries out in the storage box cdna sample test tube positioning, so
Afterwards the gene print test tube in the storage box is gripped by drive mechanism, be moved in front of two-dimensional scanner to enter after gripping
After row scanning confirms, now closure is opened and is put into thief hole, completes sampling process, and whole operation process is in access storehouse
Carry out under the low temperature environment in portion, the degree of accuracy of sampling is high, and operating process is simply efficient;
3. bracket is driven by the motion of driving chain, makes bracket move to two adjacent the storage box towards storage rack
Between, and make the storage box and bracket carry out mutually assembling positioning by the elevating movement of storage rack, so as to bracket slides just can be by
The storage box is taken out or is stored in storage rack, realizes the convenient storage of gene samples and sampling, the whole extraction process of gene samples
Carry out inside biological sample storage equipment, keep sampling operation process to be under low temperature environment, it is ensured that biological gene
The activity of sample and quality;
4. the access storehouse for quick chuck provided herein, by manipulating travel mechanism cramping body and active card are made
The multiple different sleeve being connected on bearing support is docked, and also can be carried out between the clamp device and connector of sleeve inner certainly
Dynamic docking, realizes the quick-replaceable that gene samples test tube grips head, and travel mechanism is capable of achieving the placement and assembling of sleeve, can be real
Automatic quick-replaceable purpose of existing biological specimen storage device, improves biological specimen storage efficiency, increased the suitable of equipment
The property used;
5. operator can be from the internal storage cdna sample of transferring barrel;When on the loading plate that transferring barrel is put into inside framework
When, by pulling hermatic door transferring barrel removal equipment can be carried out to pick and place cdna sample, and hermatic door and freezer storage equipment
After doorframe coordinates, transferring barrel is corresponding with the transhipment hole in storage device;Transferring barrel in the presence of elevating mechanism with thief hole
Carry out sealing docking, it is ensured that the cdna sample test tube inside access storehouse puts into the inside of transferring barrel with equal ambient;And it is whole
The cooperation of individual hermatic door and biological memory devices, it is ensured that the sealing of device interior, prevents the cooling nitrogen of device interior big
Amount leakage, improves the convenient degree and stability of operation.
Description of the drawings
Fig. 1 is a kind of overall structure diagram of biological specimen automatic access equipment that the utility model is provided;
Fig. 2 is the right side partial structural diagram of Fig. 1;
Fig. 3 is the frozen tank internal structure schematic diagram of Fig. 2;
Fig. 4 is a kind of inside partial schematic diagram of biological specimen automatic access equipment that the utility model is provided;
Fig. 5 is a kind of access chamber structure schematic diagram of biological specimen automatic access equipment that the utility model is provided;
Fig. 6 is the structural representation of clamp device in Fig. 5;
Fig. 7 is the cross-sectional schematic of Fig. 6;
Fig. 8 is the structural representation of feeding head in Fig. 6;
Fig. 9 is the structural representation of fixing body in Fig. 6;
Figure 10 is a kind of access orlop portion structural representation of biological specimen automatic access equipment that the utility model is provided;
Figure 11 is the structural representation of staving elevating mechanism in Figure 10;
Figure 12 is the structural representation of liftout pipe in Fig. 8.
Specific embodiment
Below by specific embodiment and combine accompanying drawing the utility model is described in further detail.
Fig. 1 to Figure 12 illustrates the utility model and illustrates a kind of structural representation of biological specimen automatic access equipment,
Characterized in that, including frozen tank 1, positioned at the top of frozen tank 1 extract bin 2, the sample storage rack in frozen tank 1,
The access storehouse 4 connected with extraction bin 2 and the specimen discerning system inside access storehouse 4, the sample storage rack includes
The multiple hoisting frames 6 being rotatably arranged on the chassis 5 and chassis 5 in frozen tank 1, are placed with multilayered memory box 7 on hoisting frame 6,
Hoisting frame 6 is equipped with lifting device;It is provided with the access storehouse 4 to the bracket 8 for extracting bin slip setting, support the storage box 7;
The clamp device positioned at the top of bracket 8 is provided with access storehouse 4, clamp device is equipped with the drive mechanism for driving its movement;Access
The bottom of storehouse 4 offers thief hole, and thief hole is provided with closure 9, and closure 9 is equipped with headstock gear, and the lower section of closure 9 is provided with sample
This transporter.
The plurality of hoisting frame 6 is circumferentially distributed along chassis 5, and multilayered memory box 7 is placed with hoisting frame 6, and each hoisting frame 6 sets
There is lifting grab 10;The frozen tank is provided with cover, and cover 7 is divided into fixed plate, access riser 38 and maintenance riser 39,
Access riser 38 and maintenance riser 39 lower end are equipped with correspondence and are lifting the suspension hook below grab 10;Set on the chassis 5
There is central shaft 40, the lower end rotating support of central shaft 40 in frozen tank 1, stretch out cover and be connected with storage rack electric rotating machine by upper end
41, the lower end of central shaft 40 arranges bearing and bearing block, and bearing block passes through center in the bottom of frozen tank 1, storage rack electric rotating machine 41
Axle 40 drives chassis 5 and the hoisting frame 6 above chassis 5 to rotate, and storage rack electric rotating machine 41 can arrange manual actuation handle, convenient
Manually in device external manually rotated sample storage rack.
Vertical demarcation strip 42 is provided with the lifting bin, and lifting access section, maintenance are separated into by demarcation strip 42
Lifting zone;Lift access section and the bin bottom of maintenance lifting zone and offer access lifting mouth, maintenance lifting mouth respectively, and access is carried
Rise mouth and maintenance lifted mouth respectively with access riser 38 and keep in repair the corresponding adaptation of riser 39;The bin for lifting access section sets
There is access door 43, the bin for keeping in repair lifting zone is provided with AD 3, and access door 43 is lifting slide.Lift bin to carry hoisting frame 6
Rise environment also to completely cut off with extraneous room temperature, control is in low temperature environment in bin, it is ensured that the quality of biological specimen, the roof of bin, side
Wall, diapire and demarcation strip 42 include inner layer metal plate, outer metal plates and positioned at the layer of polyurethane between the two, play very well
Insulation effect.
Lifting device includes that the access hoisting mechanism and maintenance that are connected with access riser and maintenance riser respectively are lifted
Mechanism;Access riser 38 and maintenance riser 39 are connected to access hoisting mechanism 44 and maintenance hoisting mechanism 45, access
Hoisting mechanism 44 is automatic lifting mechanism;Maintenance hoisting mechanism 45 is hand hoisting mechanism.Maintenance hoisting mechanism 45 include rope,
Rotating support is in the rocking handle of the driving wheel and driving wheel connection for keeping in repair lifting zone bottom, located at the pulley on maintenance lifting zone top;
Maintenance riser 39 is provided with enhancing ring, and one end of rope is connected to driving wheel, and other end Jing pulleys are connected to enhancing ring.Pass through
Artificial shake rocking handle, rotation driving wheel, maintenance riser 39 is lifted, and drives hoisting frame 6 to lift.Access hoisting mechanism 44 includes
Riser, the vertical rails for being fixed on riser, slip are located at the lift arm of vertical rails, rotate respectively located at riser upper and lower
Two sprocket wheels, on two sprocket wheels engage chain;Fastener is fixed with side chain between two sprocket wheels, lift arm is fixed with fastener
Connection, when sprocket wheel drives chain to move, lift arm realizes that lifting drives hoisting frame 6 to lift, while being oriented to by vertical rails, fastener
It is convenient to be carried come fixed fastener, access hoisting mechanism and maintenance by the gap in chain link with the gear shaping in insertion chain link plate
Rising mechanism can also adopt other elevating mechanisms.
The specimen discerning system is included positioned at the video camera 11 accessed at the top of storehouse 4, on the movement locus of feeding 12
Two-dimentional code reader 13 and cyclelog, the video camera 11, two-dimentional code reader 12 and drive mechanism are and programme-control
Device is electrically connected.Wherein:Video camera 11 is used for after the storage box 7 takes out in the frozen tank 1 for depositing product to be sampled, deposits described in shooting
Sample position picture in storage box 7, sends to cyclelog;Cyclelog is used to be believed according to the storage coordinate of product to be sampled
Sample position picture on breath and the storage box 7, judges whether there is sample at the storage coordinate in the storage box 7
Product, when judging that acquisition has sample, generate the first control instruction;Drive mechanism is used for according to the first control instruction, deposits from described
The sample is captured in storage box 7, and is moved to 13 at two-dimentional code reader;Two-dimentional code reader 13 is used for the label on the sample
It is scanned, obtains the number information of the sample, and sends to cyclelog;Cyclelog is additionally operable to judge the sample
Whether the number information of product is the number information of product to be sampled, when the number information of product to be sampled is judged as, generates second and controls
System instruction, control drive mechanism is placed in sample movement in transferring barrel.
The power set that the bracket 8 is provided with the location structure of the storage box 7 and drives it to slide, location structure includes being located at
The alignment pin of the bottom surface of the storage box 7 and the location hole matched with alignment pin on bracket 8 is arranged on, when bracket 8 is moved to and storage
When on the corresponding position of box 7, the storage box 7 is lifted in the presence of hoisting mechanism, makes alignment pin enter luggage with location hole
With or separate, so as to realizing being connected with each other between the storage box 7 and bracket 8 or separating, reach from cdna sample memory block
It is interior that cdna sample is picked and placeed.
The power set include transmission chain 14 and the sprocket wheel matched with transmission chain 14, and the sprocket wheel is connected with electricity
Motivation.Also include the slide rail being located in the glide direction of bracket 8, the bracket 8 is provided with the slide block matched with slide rail;The slide block
It is connected with transmission chain 14, the side wall of slide block is connected with transmission chain, bracket 8 is located at the top of slide block;Motor is in control
In the presence of device, the rotating of motor is realized, so as to be controlled to the position of slide block, make bracket 8 move to predetermined position
Put and assembled with the storage box.
The clamp device is provided with feeding 12, also including fixing body 15, the drive mechanism of the movement of drive installation body 15, consolidates
Fixed bearing support 16, the multiple feedings 12 being arranged on bearing support 16 for arranging;The upper end of the feeding 12 is and fixing body
The 15 fixing body connection ends being engaged by clamping;The outer wall of the feeding 12 be provided with placement annular groove 17, bearing support 16 have it is multiple with
Place the gap that annular groove 17 is adapted;The gap is set to and places the U-type groove that annular groove 17 matches, and U-type groove is easy to feeding head
12 take out bearing support 16 or in the vertical direction by the clamping of feeding 12 in the presence of drive mechanism, so as to fixing body 15 with
Depart between feeding 12.
The feeding 12 include sleeve 18, the rotation pressure head 19 that sets gradually in the sleeve 18 and liftout pipe 20 and
Feeding bar 21 in liftout pipe 20, liftout pipe 20 is in the interior setting that slides axially of sleeve 18;One end of pressure head 19 is rotated to drive
Dynamic connection end, the end face of the other end has pressure head cammed surface;One end of liftout pipe 20 has the material matched with pressure head cammed surface
Pipe cammed surface, the other end stretches out sleeve 18;The one end of feeding bar 21 is connected to rotation pressure head 19, and the other end stretches out liftout pipe 20;Top
Back-moving spring 22 is provided between expects pipe 20 and sleeve 18;Feeding 12 is realized gripping gene samples test tube, gene samples
The caping of test tube cap is generally all that feeding bar 21 is corresponding to be inserted into the inward recess of test tube cap, liftout with inward recess
Pipe 20 ejects gene samples test tube relative to the relative motion of feeding bar, and realization is picked and placeed to gene samples test tube;It is described to rotate pressure
The pressure head cammed surface of 19 ends will promote the expects pipe cammed surface of liftout tube end, liftout pipe 20 just may be used during rotation
The gene samples test tube of ejection feeding boom end.
The outer wall of the liftout pipe 20 is provided with multiple axial guide chutes 23, and sleeve 18 is provided with and stretches into the guiding cunning
The keeper 25 of groove 23, keeper 25 is arranged along the radial direction of sleeve 18, prevents it from following rotation pressure head 19 to rotate together, fixed
Position part 25 can be spring-loaded plunger, or locating dowel, positioning bead etc., and realization carries out spacing to liftout pipe 20, makes liftout pipe 20 along axle
Slide in line direction.
The fixing body 15 includes the connector 28 of motor 27 and the connection of motor 27 and matches with fixing body connection end
Keeper 26;The fixing body connection end of the feeding 12 is provided with draw-in groove 28;The fixing body 15 is provided with and the phase of draw-in groove 28
The keeper 26 of matching, you can realize being engaged by clamping;The draw-in groove 28 is set to circular arc-shaped ring groove and positioned at the end of feeding 12;
The keeper 26 can adopt resilient balls, the structure of elastic pin shaft, when feeding head snaps onto the inside of fixing body, keeper
26 can automatically extend into draw-in groove 28, and feeding head is locked;Conversely, fixing body 15 is in the presence of drive mechanism, can be from
It is stuck in the feeding 12 on bearing support and departs from, realizes the replacing of different feedings 12;This is a kind of embodiment party of the application
Formula, keeper can also be arranged at the end of feeding 12, and fixing body 15 is provided with the draw-in groove 28 matched with keeper 26,
Above-mentioned functions can equally be realized;Described keeper 26 be respectively positioned on feeding 12 in the radial direction and can enter in radial directions
Stretching for row elasticity, is separated with ensureing that keeper is snapped in draw-in groove 28 or with draw-in groove 28.
The end of the connector 28 matches with the drive connection end for rotating pressure head 19;The driving for rotating pressure head 19
Connection end has driving square toes;The connector 28 is provided with and the fitting recess 29 for driving square toes to match;It is described driving square toes with
The end edge of fitting recess 29 is equipped with arc angling, when feeding 12 and fixing body 15 are assembled, rotates pressure head in reset bullet
In the presence of spring 22, driving square toes are made with the phase assembly connection of fitting recess 29.
The sample extraction device includes being slideably positioned in the slide plate 30 of the lower section of access storehouse 4, is placed with and takes on slide plate 30
The corresponding transferring barrel in sample hole 31, transferring barrel is equipped with the staving elevating mechanism for driving its lifting;Erect the end of the slide plate 30
Directly it is provided with hermatic door 32.The slide plate 30 is provided with the multiple alignment pins 33 around transferring barrel;Alignment pin 33 is along vertical
Direction is fixed on slide plate 30 and with certain length, the sliding space of transferring barrel is formed between alignment pin 33.
Below slide plate 30, staving elevating mechanism includes lifting disk 34, drives 34 liters of lifting disk the staving elevating mechanism
The drive mechanism of drop;The via of correspondence lifting disk 34 is offered on slide plate 30;The lower section of the slide plate 30 is provided with installing rack, driving machine
Structure is loaded on installing rack;Described drive mechanism includes the motor 35 being located on installing rack;In the rotating shaft of the motor 35
It is provided with screw thread;The lower surface of the lifting disk 34 is vertically connected with riffled tube 36, the rotating shaft phase of riffled tube and motor 35
Matching, forms screw mandrel slide mechanism between motor 35 and riffled tube 36;Lifting disk 34 is connected with guide rod 37 straight down,
And the lower end of guide rod 37 passes the installing rack;The guide rod 37 is two, right on installing rack respectively positioned at drive mechanism both sides
The bushing coordinated with the lower slide of guide rod 37 should be set, and bushing is assemblied on installing rack.
Drive mechanism include being located at X to crossbeam, be slidably arranged in X to the Y-direction crossbeam on crossbeam and be slidably arranged in Y-direction
Z-direction vertical beam on crossbeam, slides on the Z-direction vertical beam and is provided with fixing body;The X is equal to crossbeam, Y-direction crossbeam and Z-direction vertical beam
The screw mandrel slide block mechanism for driving Y-direction crossbeam, Z-direction vertical beam and fixing body to slide is provided with, screw mandrel slide block mechanism is equipped with driving, and it is transported
Dynamic motor;Screw mandrel is rotated so as to drive Y-direction crossbeam, Z-direction vertical beam and fixing body respectively in X to crossbeam, Y-direction crossbeam and Z-direction
Slide on vertical beam, can be along X to, the drive mechanism moved of Y-direction and Z-direction so as to be formed.
The headstock gear includes the X being fixed on framework to track, and X slides on track and arranges slide block A, and slide block A consolidates
Surely Z-direction track is connected with, vertically sliding on Z-direction track has slide block B;The slide block B is connected with connecting rod, the end of connecting rod
It is connected with closure, makes closure on horizontal position, and thief hole can be closed or be opened;The slide block A
Be equipped with the power set for driving it to slide with slide block B, slide block A and slide block B carry out in the presence of power set X to and Z-direction
Both direction is moved, so as to by closure open and prevent its with sample storage device inside showing of interfering of manipulator
As.
Preferred embodiment of the present utility model is the foregoing is only, the utility model is not limited to, for this
For the technical staff in field, the utility model can have various modifications and variations.It is all it is of the present utility model spirit and principle
Within, any modification, equivalent substitution and improvements made etc. should be included within protection domain of the present utility model.