CN205593923U - Constant temperature total internal reflection micro -fluidic chip detects all -in -one - Google Patents
Constant temperature total internal reflection micro -fluidic chip detects all -in -one Download PDFInfo
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- CN205593923U CN205593923U CN201620404729.XU CN201620404729U CN205593923U CN 205593923 U CN205593923 U CN 205593923U CN 201620404729 U CN201620404729 U CN 201620404729U CN 205593923 U CN205593923 U CN 205593923U
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- chamber
- internal reflection
- total internal
- upper strata
- main frame
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Abstract
The utility model discloses a constant temperature total internal reflection micro -fluidic chip detects all -in -one, by the host computer box with handle the display and form, its characterized in that: the internal part of mainframe box is lower floor case room and upper case room is two -layer, and the lower floor installs the case room inverts fluorescence microscope, has total internal reflection light source and receiver in upper case indoor location. The inboard box wall of upper strata case room has the heating chamber. The inversion fluorescence microscope who handles display and mainframe box internal is continuous with total internal reflection light source and receiver circuit. The utility model discloses can detecting by enough total internal reflection mutually, detecting by enough inversion fluorescence microscope again, realize a tractor serves several purposes, a machine allies oneself with the requirement of surveying the different factors. And realized that detection area's temperature is even and invariable, humidity even and invariable.
Description
Technical field
This utility model relates to a kind of in-vitro diagnosis all-in-one, is more specifically belonging to a kind of constant temperature total internal reflection micro-fluidic chip detection all-in-one of the external diagnostic field of armarium.
Background technology
The diagnosis that in-vitro diagnosis carries out detecting after referring to take out blood, body fluid, tissue samples from human body and carries out, the medical diagnosis on disease of more than 80% depends on IVD the most clinically, is described as " eyes " of doctor.IVD play the most important role, particularly bed in modern society before care diagnostic in disease prevention, diagnose, monitor and the overall process of guiding treatment plays extremely important effect, be the modern diseases instrument indispensable with health control.Owing to micro-fluidic chip is developed rapidly, and the bottleneck hindering today microflow control technique to develop remains the problem manufacturing processing and application aspect limiting its development in early days.Total internal reflection optical detection technique is exactly one and meets the optical detective technology integrated with micro-fluidic chip, but, at present when technology for detection living cells both utilizing, lack the constant temperature all-in-one meeting living cells detection.
For polyfactorial disposable checkout and diagnosis such as the living cells to cancer and cardiovascular and cerebrovascular disease, need a kind of constant temperature total internal reflection micro-fluidic chip detection all-in-one.
Summary of the invention
The purpose of this utility model is to overcome the deficiencies in the prior art, it is provided that a kind of constant temperature total internal reflection micro-fluidic chip detection all-in-one.
The object of the present invention is achieved like this: a kind of constant temperature total internal reflection micro-fluidic chip detection all-in-one, it is made up of main frame casing and processing display two parts, it is characterized in that: be processed into airtight main frame casing, one side the most forward has opening, by upper and lower chamber dividing plate, box house is divided into lower floor's chamber and upper strata chamber two-layer inside casing, and the most each comfortable box opening is provided with independent lower floor's transparent doors and upper strata transparent doors.Two operation interval non-interference are easy in so design, it is to avoid pollution effect.Lower floor's chamber is provided with inverted fluorescence microscope, facing to observation window above the camera lens of inverted fluorescence microscope.Disposing inverted fluorescence microscope is to meet a tractor serves several purposes purpose, can either detect with total internal reflection, can detect with inverted fluorescence microscope again.Above the dividing plate of chamber up and down above observation window, i.e. the dividing plate of chamber up and down side in the chamber of upper strata is provided with sample stage；Fixed placement detection chip on sample stage；Total internal reflection light source and receptor is had, it is possible to realize the detection of total internal reflection directly over sample stage.Being provided with perpendicular rail on the inboard box body wall of upper strata chamber, be also horizontally installed with traverse rod on perpendicular rail, traverse rod is mutually perpendicular to perpendicular rail decussation, and total internal reflection light source and receptor are fixed by perpendicular rail or traverse rod.So it is designed to meet total internal reflection light source and receptor move vertically on perpendicular rail and fix, additionally it is possible to meet total internal reflection light source and receptor and move left and right on traverse rod and fix, it is ensured that being smoothed out of total internal reflection detection.On the inboard box body wall of upper strata chamber, also processing is provided with humidifier and the fan of disjunctor, and the humidifier of disjunctor and fan design purpose are that fan can control rotating speed by induction apparatus, the humidity required for having ensured living cells detection constant.The inboard box body wall of upper strata chamber has two-layer thermal-insulation baffle plate, is heating chamber between two-layer thermal-insulation baffle plate, is provided with the electric heater unit controlling temperature in heating chamber, has ensured the temperature required for living cells detection.In the processing of main frame casing top, air cleaner is installed to communicate with upper strata chamber, has ensured the cleannes requirement of monitored area.Processing display and the inverted fluorescence microscope in mainframe box body and total internal reflection light source and receptor circuit are connected, it is possible to control upper and lower two kinds of detection devices.
Further, described fan communicates with heating chamber；The top of heating chamber is communicated with air cleaner by air filtration layer, ensured the homogeneous temperature of upper strata chamber with constant, humidity uniformly with constant.
Further, described main frame casing is the containment housing processed by insulation material；Described lower floor transparent doors and upper strata transparent doors are all sealed thermal insulating doors.This ensure that the homogeneous temperature of detection upper strata, region chamber is with constant in case, humidity uniform.
Further, described main frame casing is cubic shaped, or cylindrical shape.It is not limited to the restriction of conventional chest cuboid.
The present invention has the advantage that relative to prior art.
1. can either detect with total internal reflection, can detect with inverted fluorescence microscope again, it is achieved a tractor serves several purposes, the requirement of a machine translocation difference factor.
2. combine the integration with all-in-one by total internal reflection detection technique, two kinds of technology of microfluidic chip technology, it is achieved that the homogeneous temperature in detection region with constant, humidity uniform with constant.
Accompanying drawing explanation
Fig. 1 is schematic front view of the present utility model.
Fig. 2 is left view schematic diagram of the present utility model.
Wherein: 1. main frame casing；2. lower floor's chamber；3. inverted fluorescence microscope；4. observation window；5. upper and lower chamber dividing plate；6. sample stage；7. humidifier；8. fan；9. traverse rod；10. total internal reflection light source and receptor；11. air cleaners；12. erect rail；13. upper strata chamber；14. upper strata transparent doors；15. detection chip；16. incident illumination calibration scales；17. lower floor's transparent doors；18. processing display；19. thermal-insulation baffle plates；20. heating chambers；21. air filtration layers.
Detailed description of the invention
See Fig. 1, Fig. 2, constant temperature total internal reflection micro-fluidic chip detection all-in-one, it is made up of main frame casing 1 and processing display 18, it is characterized in that: airtight main frame casing 1 one side the most forward has opening, by upper and lower chamber dividing plate 5, box house is divided into lower floor's chamber 2 and upper strata chamber 13 two-layer inside casing, and the most each comfortable box opening is provided with independent lower floor's transparent doors 17 and upper strata transparent doors 14；Lower floor's chamber 2 is provided with inverted fluorescence microscope 3, facing to observation window 4 above inverted fluorescence microscope 3 camera lens；Above the dividing plate of chamber up and down 5 above observation window 4, i.e. the dividing plate 5 of chamber up and down side in upper strata chamber 13 is provided with sample stage 6；Fixed placement detection chip 15 on sample stage 6；Total internal reflection light source and receptor 10 is had directly over sample stage 6；Being provided with perpendicular rail 12 on the inboard box body wall of upper strata chamber 13, be also horizontally installed with traverse rod 9 on perpendicular rail 12, traverse rod 9 is mutually perpendicular to perpendicular rail 12 decussation；Total internal reflection light source and receptor 10 are fixed by perpendicular rail 12 or traverse rod 9, and during use, needs according to detection region are mobile on perpendicular rail 12 or traverse rod 9 adjusts fixing total internal reflection light source and receptor 10, it is achieved total internal reflection most preferably launch receiving position.On the inboard box body wall of upper strata chamber 13, also processing is provided with disjunctor fan 8 and the humidifier 7 that humidity sensor controls.The inboard box body wall of upper strata chamber 13 has two-layer thermal-insulation baffle plate 19, is heating chamber 20 between two-layer thermal-insulation baffle plate 19, is provided with the electric heater unit controlling temperature, it is provided that the temperature required for living cells in heating chamber 20.In the processing of main frame casing 1 top, air cleaner 11 is installed to communicate with upper strata chamber 13；Processing display 18 and the inverted fluorescence microscope 3 in main frame casing 1 and total internal reflection light source and receptor 10 circuit are connected.
Above-mentioned technical conditions, the described fan 8 of optimization communicates with heating chamber 20；The top of heating chamber 20 is communicated with air cleaner 11 by air filtration layer 21, makes the air cleaner of upper strata chamber 13 and keeps certain blast, preventing pollution detection region.
Above-mentioned technical conditions, the described main frame casing 1 of optimization is the containment housing processed by insulation material；Described lower floor transparent doors 17 and upper strata transparent doors 14 are all sealed thermal insulating doors.
Above-mentioned technical conditions, the described main frame casing 1 of optimization is cubic shaped, or cylindrical shape.
Claims (4)
1. a constant temperature total internal reflection micro-fluidic chip detection all-in-one, it is made up of main frame casing (1) and processing display (18), it is characterized in that: main frame casing (1) one side the most forward has opening, by upper and lower chamber dividing plate (5), box house is divided into lower floor's chamber (2) and upper strata chamber (13) two-layer inside casing, and the most each comfortable box opening is provided with independent lower floor's transparent doors (17) and upper strata transparent doors (14)；Lower floor's chamber (2) is provided with inverted fluorescence microscope (3), facing to observation window (4) above the camera lens of inverted fluorescence microscope (3)；Above the dividing plate of the chamber up and down (5) of observation window (4) top, i.e. dividing plate (5) side of chamber up and down in upper strata chamber (13) is provided with sample stage (6)；The upper fixed placement detection chip (15) of sample stage (6)；Total internal reflection light source and receptor (10) is had directly over sample stage (6)；Being provided with perpendicular rail (12) on the inboard box body wall of upper strata chamber (13), be also horizontally installed with traverse rod (9) on perpendicular rail (12), traverse rod (9) is mutually perpendicular to perpendicular rail (12) decussation；Total internal reflection light source and receptor (10) are fixed by perpendicular rail (12) or traverse rod (9)；On the inboard box body wall of upper strata chamber (13), also processing is provided with humidifier (7) and the fan (8) of disjunctor；The inboard box body wall of upper strata chamber (13) has two-layer thermal-insulation baffle plate (19), is heating chamber (20) between two-layer thermal-insulation baffle plate (19), is provided with the electric heater unit controlling temperature in heating chamber (20)；In the processing of main frame casing (1) top, air cleaner (11) is installed to communicate with upper strata chamber (13)；Processing display (18) and the inverted fluorescence microscope (3) in main frame casing (1) and total internal reflection light source and receptor (10) circuit are connected.
Constant temperature total internal reflection micro-fluidic chip the most according to claim 1 detection all-in-one, it is characterised in that: described fan (8) communicates with heating chamber (20)；The top of heating chamber (20) is communicated with air cleaner (11) by air filtration layer (21).
Constant temperature total internal reflection micro-fluidic chip the most according to claim 1 detection all-in-one, it is characterised in that: described main frame casing (1) is the containment housing processed by insulation material；Described lower floor transparent doors (17) and upper strata transparent doors (14) are all sealed thermal insulating doors.
Constant temperature total internal reflection micro-fluidic chip the most according to claim 1 detection all-in-one, it is characterised in that: described main frame casing (1) is cubic shaped, or cylindrical shape.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620404729.XU CN205593923U (en) | 2016-05-08 | 2016-05-08 | Constant temperature total internal reflection micro -fluidic chip detects all -in -one |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620404729.XU CN205593923U (en) | 2016-05-08 | 2016-05-08 | Constant temperature total internal reflection micro -fluidic chip detects all -in -one |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205593923U true CN205593923U (en) | 2016-09-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620404729.XU Withdrawn - After Issue CN205593923U (en) | 2016-05-08 | 2016-05-08 | Constant temperature total internal reflection micro -fluidic chip detects all -in -one |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN205593923U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105784663A (en) * | 2016-05-08 | 2016-07-20 | 重庆科技学院 | Constant-temperature total-internal-reflection microfluidic-chip detection all-in-one machine |
-
2016
- 2016-05-08 CN CN201620404729.XU patent/CN205593923U/en not_active Withdrawn - After Issue
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105784663A (en) * | 2016-05-08 | 2016-07-20 | 重庆科技学院 | Constant-temperature total-internal-reflection microfluidic-chip detection all-in-one machine |
| CN105784663B (en) * | 2016-05-08 | 2018-06-12 | 重庆科技学院 | A kind of constant temperature total internal reflection micro-fluidic chip detects all-in-one machine |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20160921 Effective date of abandoning: 20180612 |
|
| AV01 | Patent right actively abandoned |