CN205313433U - Antibody purification device - Google Patents
Antibody purification device Download PDFInfo
- Publication number
- CN205313433U CN205313433U CN201520512660.8U CN201520512660U CN205313433U CN 205313433 U CN205313433 U CN 205313433U CN 201520512660 U CN201520512660 U CN 201520512660U CN 205313433 U CN205313433 U CN 205313433U
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- China
- Prior art keywords
- purifying column
- end cover
- hole
- aperture
- purification column
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Abstract
The utility model discloses an antibody purification device, include purifying column, frame, lower hole, go up hole, upper end cover, bottom end cover and baffle, in the lower hole and last hole of purifying column setting on the frame, lower hole aperture be less than the aperture in hole, purifying column go up the lower extreme and be provided with upper end cover, bottom end cover respectively, purifying column bottom for the toper, purifying column in be provided with a plurality of layers of filtration membrane, filtration membrane's aperture down reduces from last in proper order, install the back flush pipe on one side of the last filler of having placed of filtration membrane, purifying column lower extreme, the outer parcel of purifying column is free chamber layer, cavity layer one side lower extreme is equipped with the water inlet, is equipped with the delivery port on the opposite side, still be equipped with shock dynamo on the frame. The utility model discloses simple structure, the purification is effectual, and convenient operation is succinct, and the practicality is strong, can set for purifying column's temperature simultaneously as required, and also accessible back flush pipe carries out the back flush to crossing filtration membrane, has prolonged purifying column's life.
Description
Technical field
The utility model relates to biological technical field, it is specifically related to a kind of antibody purification device.
Background technology
Antibody is a kind of special protein molecule, by as the reagent of in-vitro diagnosis, the medicine of disease therapy, the aglucon etc. of immunoaffinity chromatography. Life science, biotechnology and medical field have a wide range of applications. Especially antibody is as the core reagent of various immunoassay, plays a part most important to sensitivity, the specificity of immunoassay result. Prepare high specific, basis that the antibody of high-titer is immunological technique, but the antibody using which kind of technology of preparing all needs to carry out purifying.
Antibody product is mainly derived from the biological raw material such as plasma component or animal cell culture supernatant liquor of donor and all kinds of animal. The purification devices mainly taked at present has chromatography column purification devices, ammonium sulfate precipitation device, and these devices all exist some defects: chromatography column purification specificity is good, but device and operate loaded down with trivial details, it is difficult to carry out the high-throughput fast purifying of the property researched and developed scale; Ammonium sulfate precipitation purification specificity is poor, and purification process is loaded down with trivial details and length consuming time.
Practical novel content
For the deficiency existed in prior art, the utility model object is to provide a kind of antibody purification device, and structure is simple, and purification effect is good, succinctly easy to operate, practical.
In order to realize above-mentioned purpose, the utility model realizes by the following technical solutions: a kind of antibody purification device, comprise purification column, framework, lower opening, upper hole, upper end cover, lower end cover and dividing plate, in the lower opening that purification column is arranged on framework and upper hole, described lower opening aperture is less than the aperture in hole, described purification column upper and lower ends is respectively arranged with upper end cover, lower end cover, is taper bottom described purification column; Some layers of filtering membrane it are provided with in described purification column, the aperture of filtering membrane reduces from top to bottom successively, described filtering membrane is placed with filler, the lower end side of purification column is provided with backwash tube, described purification column is wrapped with cavity layer, the lower end in described cavity layer side is provided with water-in, and another upper end, side is provided with water outlet, and described framework is also provided with vibration motor.
The dividing plate being provided with intersection between the lower opening of the described correspondence on framework, upper hole, avoids the antibody generation cross infection in each purification column.
The lower opening of described framework, upper hole are arranged on the lower planes plate on framework.
The beneficial effects of the utility model: structure is simple, and purification effect is good, succinctly easy to operate, practical, can set the temperature of purification column simultaneously as required, it is possible to by backwash tube, to crossing, filtering membrane carries out back flushing, extends the work-ing life of purification column.
Accompanying drawing explanation
Below in conjunction with the drawings and specific embodiments, the utility model is described in detail;
Fig. 1 is structural representation of the present utility model;
Fig. 2 is the vertical view of Fig. 1.
Fig. 3 is the structural representation of purification column in the utility model.
Embodiment
For the utility model is realized technique means, creation characteristic, reach object and effect is easy to understand, below in conjunction with embodiment, set forth the utility model further.
With reference to Fig. 1-3, this embodiment is by the following technical solutions: a kind of antibody purification device, comprise purification column 1, framework 2, lower opening 3, upper hole 4, upper end cover 5, lower end cover 6 and dividing plate 7, purification column 1 arranges in lower opening 3 on the frame 2 and upper hole 4, described lower opening 3 aperture is less than the aperture in hole 4, described purification column 1 upper and lower ends is respectively arranged with upper end cover 5, lower end cover 6, is taper bottom described purification column 1; It is provided with some layers of filtering membrane in described purification column 1, the aperture of filtering membrane reduces from top to bottom successively, described filtering membrane is placed with filler, purification column 1 time end side is provided with backwash tube 8, described purification column 1 is wrapped with cavity layer 9, the lower end in described cavity layer 9 side is provided with water-in 10, and another upper end, side is provided with water outlet 11, and described framework 2 is also provided with vibration motor.
It is noted that be provided with the dividing plate 7 of intersection between the lower opening 3 of correspondence on described framework 2, upper hole 4, avoid the antibody generation cross infection in each purification column.
In addition, the lower opening 3 of described framework 2, upper hole 4 are arranged on lower planes plate on the frame 2.
This concrete enforcement structure is simple, and purification effect is good, succinctly easy to operate, practical, can set the temperature of purification column as required simultaneously, it is possible to by backwash tube, to crossing, filtering membrane carries out back flushing, extends the work-ing life of purification column.
This embodiment structure is simple, and purification effect is good, succinctly easy to operate, practical.
More than show and describe ultimate principle of the present utility model and main characteristic sum advantage of the present utility model. The technician of the industry should understand; the utility model is not restricted to the described embodiments; what describe in above-described embodiment and specification sheets just illustrates principle of the present utility model; under the prerequisite not departing from the utility model spirit and scope; the utility model also has various changes and modifications, and these changes and improvements all fall within the scope of claimed the utility model. The claimed scope of the utility model is defined by appending claims and equivalent thereof.
Claims (3)
1. an antibody purification device, comprise purification column (1), framework (2), lower opening (3), upper hole (4), upper end cover (5), lower end cover (6) and dividing plate (7), it is characterized in that, in the lower opening (3) that purification column (1) is arranged on framework (2) and upper hole (4), described lower opening (3) aperture is less than the aperture of hole (4), described purification column (1) upper and lower ends is respectively arranged with upper end cover (5), lower end cover (6), and described purification column (1) bottom is taper;It is provided with some layers of filtering membrane in described purification column (1), the aperture of filtering membrane reduces from top to bottom successively, described filtering membrane is placed with filler, the lower end side of purification column (1) is provided with backwash tube (8), described purification column (1) is wrapped with cavity layer (9), the lower end in described cavity layer (9) side is provided with water-in (10), another upper end, side is provided with water outlet (11), and described framework is also provided with vibration motor on (2).
2. antibody purification device according to claim 1, it is characterised in that, it is provided with the dividing plate (7) of intersection between the lower opening (3) of the described correspondence on framework (2), upper hole (4).
3. antibody purification device according to claim 1, it is characterised in that, the lower opening (3) of described framework (2), upper hole (4) are arranged on the lower planes plate on framework (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520512660.8U CN205313433U (en) | 2015-07-15 | 2015-07-15 | Antibody purification device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520512660.8U CN205313433U (en) | 2015-07-15 | 2015-07-15 | Antibody purification device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205313433U true CN205313433U (en) | 2016-06-15 |
Family
ID=56188039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520512660.8U Expired - Fee Related CN205313433U (en) | 2015-07-15 | 2015-07-15 | Antibody purification device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN205313433U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110981954A (en) * | 2020-01-23 | 2020-04-10 | 中科宝承生物医学科技有限公司 | Antibody purification equipment and operation method thereof |
-
2015
- 2015-07-15 CN CN201520512660.8U patent/CN205313433U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110981954A (en) * | 2020-01-23 | 2020-04-10 | 中科宝承生物医学科技有限公司 | Antibody purification equipment and operation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160615 Termination date: 20170715 |