CN205198133U - Ablation catheter - Google Patents

Abstract

The utility model provides an ablation catheter, it includes: melt the subassembly, including flexible outer tube, the cover in flexible outer tube the stay tube, wear to establish the wire guide pipe in flexible outer tube and establish at least one electrode of flexible outer wall of the outer tube, the stay tube can be sent at expand configuration and low profile and change between the configuration, the stay tube is equipped with at least one rather than the communicating grooving of lumen, flexible outer tube is equipped with at least one fill orifice that link up its outer wall, the fill orifice is at least with one the grooving is linked together, the distal end of flexible outer tube seals, and with the lumen of stay tube is linked together fills the pipe.

Description

Ablation catheter

Technical field

This utility model relates to medical instruments field, particularly relates to a kind of ablation catheter.

Background technology

Hypertension is common chronic disease, and in its Forming Mechanism, renin angiotensin aldosterone system (ReninAngiotensinAldosteroneSystem, RAAS) plays a key effect as important regulating blood pressure system.RAAS is by maintaining the balance of body water, electrolyte and blood pressure to the adjustment of heart, blood vessel, kidney.Research confirms, RAAS causes hypertension by following three approach: (1) RAAS activates and causes sodium retention; (2) RAAS activates can increase sympathetic nervous system activity; (3) activate can direct vasoconstrictive for RAAS.Wherein, renal artery sympathetic nerve plays decisive role for bringing out with keeping system hypertension, and its overacfivity makes the blood pressure of hyperpietic be difficult to reduce.

Melt for renal artery is orthosympathetic through conduit renal artery sympathetic nerve ablation, its typical model of action is by modulating unit through conduit, as electrode, ultrasonic transducer, medicine etc. are transported to the renal artery Ink vessel transfusing of patient body, and by these modulating units to renal artery blood vessel delivered energy, as electric energy, acoustic energy, heat energy etc., to reach the renal sympathetic nerve that melts in renal artery blood vessel wall and to reduce the object of patients' blood.

Existing radio frequency ablation catheter is typically provided with single or multiple electrode, and the far-end as the main body of conduit 80 installs multiple electrode 84 (consulting Fig. 1).Multiple electrode 84 rely on the support of the helical structure of catheter main body 80 and blood vessel adherent, and form circuit loop with the indifferent plate electrode (not shown) of body surface, thus renal sympathetic nerve melted.The far-end of conduit 80 has a spiral control member 82.Control member 82 is the tubular structures be made up of the Nitinol multi-stranded of densification.Flexible layer 81 is coated with outside control member 82.This electrode 84 is connected with radiofrequency generator (not shown) by wire (not shown); Described wire (not shown) is arranged in the interlayer between flexible layer 81 and control member 82.

Ablation catheter 80 is when melting, and its electrode can only rely on the blood flow of surrounding to cool.But cardiac pumping function has periodically, arteriorenal Oligemia during heart blood back, now can be reduced to the cooling effect of electrode by blood flow, and electrode surface temperature rises, and increases blood condenses into thrombosis risk at electrode surface, or causes vasospasm.

Utility model content

Based on this, be necessary to provide a kind of ablation catheter, it can be eliminated blood flow and cool the uncertainty brought, and reduces thrombotic probability.

This utility model provides a kind of ablation catheter, it comprises: ablation member, comprise flexible outer tube, the stay pipe be enclosed within flexible outer tube, be located in the wire leading pipe in flexible outer tube and be located at least one electrode of described flexible outer tube outer wall, described stay pipe can be changed between expanded configuration and low profile delivery configuration, described stay pipe is provided with at least one grooving communicated with its tube chamber, described flexible outer tube is provided with at least one fill orifice of its outer wall through, described fill orifice is at least connected with a described grooving, and the far-end of described flexible outer tube is closed; And the intrusion pipe to be connected with the tube chamber of described stay pipe.

Wherein in an embodiment, the far-end of described intrusion pipe is positioned at described stay pipe, the proximal seal of described stay pipe.

Wherein in an embodiment, described stay pipe comprises relative proximal part and distal portions, and described grooving is between described proximal part and distal portions.

Wherein in an embodiment, described fill orifice is near described electrode.

Wherein in an embodiment, described fill orifice runs through described electrode.

Wherein in an embodiment, described flexible outer tube comprises at least one group of fill orifice be intervally arranged along described flexible outer tube length direction.

Wherein in an embodiment, the diameter of each fill orifice is 0.02-0.5 millimeter.

Wherein in an embodiment, described ablation member comprises multiple electrode, and the projection of the plurality of electrode on the cross section of the axis perpendicular to described ablation catheter is positioned at circumferentially same.

Wherein in an embodiment, described wire leading pipe is located in described stay pipe, and the far-end of described intrusion pipe is located between described stay pipe and described wire leading pipe.

Wherein in an embodiment, described ablation catheter also comprises the catheter main body of hollow, and described ablation member is located at the far-end of described catheter main body, and described intrusion pipe is from the proximal extension of described catheter main body to the near-end of described stay pipe.

Compared with ablation catheter of the prior art, the ablation catheter of this programme adds perfusion functional, when melting, ablation member obtains the cooling liquid of stable and consistent flow from charge pump, can to the electrode near fill orifice and tissue cooling, thus this function can be eliminated blood flow and cools the uncertainty brought, for electrode and surrounding them tissue provide consistent, cooling effect reliably, reduce thrombotic probability.

Accompanying drawing explanation

Fig. 1 is the structural representation of existing ablation catheter;

The schematic diagram of the ablation catheter system that Fig. 2 provides for this utility model one embodiment;

Fig. 3 is the ablation catheter of ablation catheter system in Fig. 2 schematic diagram when being in low profile delivery configuration;

Fig. 4 is the ablation catheter of ablation catheter system in Fig. 2 schematic diagram when being in expanded configuration;

Fig. 5 is the top view of the far-end of ablation catheter in Fig. 3;

Fig. 6 is the schematic diagram of the stay pipe of ablation catheter in Fig. 3;

Fig. 7 is the sectional view of C part in Fig. 4;

Fig. 8 is the sectional view of part B in Fig. 4;

Fig. 9 is the sectional view of part A in Fig. 4;

The phantom of the ablation catheter that Figure 10 provides for another embodiment of this utility model;

Figure 11 is this utility model phantom of ablation catheter of providing of an embodiment again.

Detailed description of the invention

For enabling above-mentioned purpose of the present utility model, feature and advantage become apparent more, are described in detail detailed description of the invention of the present utility model below in conjunction with accompanying drawing.Set forth a lot of detail in the following description so that fully understand this utility model.But this utility model can be much different from alternate manner described here to implement, those skilled in the art can when doing similar improvement without prejudice to when this utility model intension, and therefore this utility model is by the restriction of following public concrete enforcement.

It should be noted that, in intervention field, usually one end near for relative operator is called near-end, relative operator one end far away is called far-end.

Unless otherwise defined, all technology used herein and scientific terminology are identical with belonging to the implication that those skilled in the art of the present utility model understand usually.The object of the term used in description of the present utility model herein just in order to describe specific embodiment, is not intended to be restriction this utility model.Term as used herein " and/or " comprise arbitrary and all combinations of one or more relevant Listed Items.

Refer to Fig. 2, a kind of can admittance silk and the ablation catheter system 10 of band liquid coolant perfusion functional comprises ablation catheter 100 (hereinafter referred to as conduit 100), radiofrequency generator 104 and charge pump 105.Radiofrequency generator 104 can be configured to via automatic control algorithm and/or under the control of clinician, radio-frequency (RF) energy is sent by the electrode 112 of connection cord 115 conductive pipe 100, and form loop with the indifferent plate electrode (not shown) of patient body-surface, thus melt the tissue contacted with electrode 112.Charge pump 105 also can with radiofrequency generator 104 communication, the flow velocity of liquid coolant that namely charge pump 105 pumps is associated with the energy output of radiofrequency generator 105.When the temperature of the electrode 112 of ablation member 101 is too high, its by this result feedback to radiofrequency generator 104, the control algolithm of radiofrequency generator 104 by himself associating with charge pump 104, by the flow velocity of adjustment charge pump 105, as increased the flow velocity of liquid coolant, to make the surrounding tissue of electrode 112 and contact thereof obtain more cooling and rinse, thus the temperature of surrounding tissue reducing electrode 112 and be in contact with it.

Conduit 100 comprises ablation member 101, catheter main body 102 and the joystick 103 in elongate shape of hollow.

Ablation member 101 comprises support tubes 111 and at least one is assemblied in electrode 112 in support tubes 111.See also Fig. 3, ablation member 101 is configured to be delivered to Renal vascular with low profile delivery configuration (such as, substantially linear or near linear shape) under the constraint of seal wire 120.See also Fig. 4, when being delivered to the target position in Renal vascular, seal wire 120 is withdrawn from ablation member, ablation member 101 returns to nature shape, namely expanded configuration is configured to (such as, helical form or approximate helical shape substantially), in Renal vascular target position delivery of energy.Ablation member 101 can use various suitable mechanism or technology (such as, self-expanding) to change between low profile delivery configuration and expanded configuration.

The far-end of ablation member 101 can utilize such as hurtless measure top 113 to stop conduit 100, can not scratch blood vessel wall when sending in the blood vessel to make ablation member 101, and top 113 also can be that another element is bonded on the far-end of ablation member 101 and is formed.

Conduit 100 can be configured to be delivered in Renal vascular through overall exchange guidewire (OTW) technology, wherein seal wire 120 is delivered in Renal vascular by initial, then the top 113 of seal wire 120 near-end through ablation member 101 is penetrated into conduit 100, and along seal wire 120, conduit 100 is pushed in Renal vascular.Seal wire 120 can be at least part of withdraw from or insert ablation member 101 from ablation member 101 and stretch out top 113, so that ablation member 101 is changed between expanded configuration (Fig. 3) and low profile delivery configuration (Fig. 4).

Ablation member 101 comprises at least one electrode 112 and the support tubes 111 for supporting at least one electrode 112.

Refer to Fig. 5, preferably, in the present embodiment, the quantity of electrode 112 is 4, proximally look vertically from the top 113 of ablation member, the projection of electrode 112 on the cross section of the axis perpendicular to catheter main body 102 is positioned at circumferentially same, and is evenly distributed in this circumferentially, and the angle namely apart between the nearest projection of electrode 112 of two and the line in the center of circle of this circle is 90 °.Multiple electrode 112 can be configured to side by side, optionally or the independent delivery energy of order, or also can between its any required combination delivery of energy.Described electrode 112 can be band shape or tubular structure, and it is by mold pressing or use binding agent to be attached in support tubes 111.Described electrode 112 can be formed by any suitable metal material, such as, and gold, platinum, platinumiridio etc.In the wire be connected with electrode 112 and wire 117 (see Fig. 8) interlayer between flexible outer tube 115 and stay pipe 116 be connected with sensor.

At least side closing at least one electrode 112 also has at least one fill orifice 114.Liquid coolant arrives fill orifice 114 from the cooling passage of charge pump 105 in conduit 100, and spray from fill orifice 114, energy delivery elements and the tissue be in contact with it are washed away and cooling, and take away the heat of electrode 112 and surrounding tissue thereof, effectively reduce the temperature of the tissue contacted with electrode 112 thus, thus the blood vessel wall contacted with electrode 112 can be avoided to sustain damage or damage is reduced.

See also Fig. 4 and Fig. 7, described support tubes 111 can change between above-mentioned expanded configuration and low profile delivery configuration, it stay pipe 116 comprising flexible outer tube 115 and be enclosed within flexible outer tube 115.

Flexible outer tube 115 can be made up of polymeric material, such as pebax ^tM, PET, polyolefin, the material such as PI.Flexible outer tube 115 is closely linked by the mode of hot melt and stay pipe 116, also fixes the position of each wire simultaneously.Multiple fill orifice 114 circumferential array is on flexible outer tube 115, and each fill orifice 114 all runs through the tube wall of flexible outer tube 115.Arbitrary quantity during the quantity of fill orifice 114 can be 1 to 40.Multiple fill orifice can be spaced along the length direction of flexible outer tube 115 by group, such as, can be spaced by 3 groups of fill orifices.The line of the multiple fill orifices 114 often in group forms the annulus coaxial with flexible outer tube 115 in flexible outer tube 115 circumference.The diameter of fill orifice 114 can be 0.02 to 0.5mm, and preferably, at least one near side edges of electrode 112 has the annulus of 1-2 fill orifice 114 formation, and the quantity of fill orifice 114 is 4 to 10, and the diameter of fill orifice 114 is 0.08 to 0.03mm.Be understandable that, some fill orifices in multiple fill orifice 114 also can be arranged the shapes such as triangle, circle, tetragon, are not limited to present embodiment, can set as required.

Stay pipe 116 can be used to as the ablation member 101 of conduit 100 provides spiral or helical configuration substantially.Stay pipe 116 is tubular structure, such as NiTi pipe, its can use laser, spark machined, electrochemistry grinding or other suitable means cuttings etc. formed required for length and shape, to adapt to the Renal vascular of difformity and size.Stay pipe 116 can select to have hyperelastic NiTi pipe through cut and thermal finalization make, it has relative proximal part 122 and distal portions 123 (consulting Fig. 6); Proximal part 122 and distal portions 123 have certain length, and described length is 0-10mm, and preferably, described length is 2-5mm.In the present embodiment, the length of proximal part 122 and distal portions 123 is equal, and is 3 millimeters.Be understandable that, the length of proximal part 122 can be greater than the length of distal portions 123, so that can be connected with catheter main body 102 by stay pipe 116 better.

There is between the proximal part 122 of stay pipe 116 and distal portions 123 multiple grooving 121 (i.e. grooving 121 and stay pipe 116 intracavity inter-connection) running through interior pipe 116 tube wall formed after lasser cutting.At least one grooving in multiple grooving 121 is connected with fill orifice 114.Adjust the rigidity of stay pipe 116 by adjusting the quantity of grooving 121, width and spacing, the rigidity of adjustable support pipe fitting 111, thus reach optimum helical configuration with the adherent performance of helical configuration and Renal vascular making ablation member 101.In the present embodiment, multiple grooving 121 forms a continuous print helical form grooving jointly.Be understandable that, multiple grooving can also be spaced apart, and adjacent two groovings head and the tail are not connected.Will also be appreciated that in multiple grooving and also can form a continuous print helical form grooving by some grooving, grooving adjacent with this helical form grooving in remaining grooving and this helical form grooving spaced apart.

Conduit 100 also comprises a seal wire sleeve pipe 124 be disposed in stay pipe 116.The inner chamber of seal wire sleeve pipe 124 can be used to send standard medical guiding wire 120, and such as, diameter is the seal wire of 0.356mm, can realize thus with in overall exchange guidewire (OTW, over-the-wire) technology delivery catheter 100 to Renal vascular.Seal wire sleeve pipe 124 can be made up of polymeric material, such as pebax ^tM, PET, polyolefin, PI etc.The far-end 125 of flexible outer tube 115 flushes with the far-end 126 of described seal wire sleeve pipe 124, makes both be closely linked and close by hot melt or encapsulating etc., and the distal openings of seal wire sleeve pipe 124.Preferably, the mode of hot melt is selected the inwall of the far-end 125 of the outer wall of the far-end 126 of seal wire sleeve pipe 124 and flexible outer tube 115 can be combined together.Be understandable that, seal wire sleeve pipe 124 also can be arranged between stay pipe 116 and flexible outer tube 115; When low profile delivery configuration, seal wire sleeve pipe 124 is parallel with stay pipe 116, also can realize the purpose of this utility model.

See also Fig. 8, conduit 100 also comprises an intrusion pipe 130 be disposed in catheter main body 102.Intrusion pipe 130 has irrigation lumen 132, its proximally handle 103 to the distal shaft of catheter main body 102 to running through catheter main body 102.The far-end 131 of intrusion pipe 130 is fixed in the stay pipe 116 of ablation member 101, and with the intracavity inter-connection of stay pipe 116.In the near-end 122 of stay pipe 116, fill with fluid sealant 133, to make the far-end 131 of intrusion pipe 130 and seal wire sleeve pipe 124 fix within it, and make the proximal seal of the stay pipe 116 of this support tubes 111, and the distal openings of intrusion pipe 130 is not covered by fluid sealant 133.

Be understandable that, the near-end of stay pipe 116 can pass through seal cap sealing, and now, the near-end of intrusion pipe 130 and seal wire sleeve pipe 124 all passes from seal cover.It will also be appreciated that, if the central shaft of the central shaft of intrusion pipe 130 and stay pipe 116 near-end is coaxial, and the far-end outer wall of intrusion pipe 130 be fixed in stay pipe 116 near-end inwall on or the far-end inwall of intrusion pipe 130 be fixed in stay pipe 116 near-end outer wall on or the proximal face of intrusion pipe 130 far-end end face and stay pipe 116 fits together time, stay pipe 116 near-end also can realize the purpose of this utility model without fluid sealant or seal cap sealing.

As mentioned above, distal openings sealing (in Fig. 4 C place) of support tubes 111 and proximal openings sealing (in Fig. 4 B place) of support tubes 111, that is, define a filling cavity 127 between stay pipe 116 and seal wire sleeve pipe 124, described filling cavity 127 has been communicated with fill orifice 114 and intrusion pipe 130.As shown in Figure 9, fill orifice 114 circumference of series of identical size or non-equidimension is distributed on the flexible outer tube 115 of electrode 112 both sides, described part or all of fill orifice 114 is positioned on the grooving 121 of stay pipe 116, and is connected with filling cavity 127 through grooving 121.Liquid coolant is delivered into intrusion pipe 130 from charge pump 105, far-end 131 through intrusion pipe 130 is sent into filling cavity 127, now, liquid coolant will be arrived fill orifice 114 and is delivered to electrode 112 and contacts with electrode 112 surrounding tissue by grooving 121, the path that liquid coolant as shown by the arrows in Figure 9 flows through, and the surrounding tissue that electrode 112 contacts with it is washed away and cooled, thus effectively reduce the temperature of the surrounding tissue that electrode 112 contacts with it, cool to eliminate blood flow the uncertainty brought, reduce thrombotic probability.

Refer to Figure 10, the ablation catheter of another embodiment of this utility model is identical substantially with ablation catheter 10, and difference is, the radial penetrating electrode 112 of fill orifice 135 of series of identical size or non-equidimension, and is connected with filling cavity 127 through grooving 121.Liquid coolant is delivered into intrusion pipe 130 from charge pump 105, far-end 131 through intrusion pipe 130 is sent into filling cavity 127, now, because the distal portions of filling cavity 127 and proximal part seal all, liquid coolant will be arrived fill orifice 135 and is delivered to electrode 112 and contacts with electrode 112 surrounding tissue by grooving 121, the path that liquid coolant as shown by the arrows in Figure 10 flows through.

Refer to Figure 11, the ablation catheter of this utility model embodiment is again identical substantially with ablation catheter 10, difference is, the fill orifice 114 of series of identical size or non-equidimension is distributed on the flexible outer tube 115 of electrode 112 both sides, and the fill orifice 135 of series of identical size or non-equidimension runs through energy electrode 112 and is connected with filling cavity 127 through grooving 121.Liquid coolant is delivered into intrusion pipe 130 from charge pump 105, far-end 131 through intrusion pipe 130 is sent into filling cavity 127, now, because the distal portions of filling cavity 127 and proximal part seal all, liquid coolant will be arrived fill orifice 114 and fill orifice 135 and is delivered to electrode 112 and contacts with electrode 112 surrounding tissue by grooving 121, the path that the liquid coolant as shown in arrow in Figure 11 flows through.

It is worth mentioning that, in embodiments more of the present utility model, the mutual alignment relation of intrusion pipe and stay pipe and annexation are not limited to aforementioned, as long as can meet the filling cavity that formation communicates with grooving between intrusion pipe, stay pipe.

The above embodiment only have expressed several embodiment of the present utility model, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to this utility model the scope of the claims.It should be pointed out that for the person of ordinary skill of the art, without departing from the concept of the premise utility, can also make some distortion and improvement, these all belong to protection domain of the present utility model.Therefore, the protection domain of this utility model patent should be as the criterion with claims.

Claims (10)

1. an ablation catheter, it comprises:

Ablation member, comprise flexible outer tube, the stay pipe be enclosed within flexible outer tube, be located in the wire leading pipe in flexible outer tube and be located at least one electrode of described flexible outer tube outer wall, described stay pipe can be changed between expanded configuration and low profile delivery configuration, described stay pipe is provided with at least one grooving communicated with its tube chamber, described flexible outer tube is provided with at least one fill orifice of its outer wall through, described fill orifice is at least connected with a described grooving, and the far-end of described flexible outer tube is closed;

And the intrusion pipe to be connected with the tube chamber of described stay pipe.

2. ablation catheter according to claim 1, is characterized in that, the far-end of described intrusion pipe is positioned at described stay pipe, the proximal seal of described stay pipe.

3. ablation catheter according to claim 1, is characterized in that, described stay pipe comprises relative proximal part and distal portions, and described grooving is between described proximal part and distal portions.

4. ablation catheter according to claim 1, is characterized in that, described fill orifice is near described electrode.

5. ablation catheter according to claim 1, is characterized in that, described fill orifice runs through described electrode.

6. ablation catheter according to claim 1, is characterized in that, described flexible outer tube comprises at least one group of fill orifice be intervally arranged along described flexible outer tube length direction.

7. ablation catheter according to claim 6, is characterized in that, the diameter of each fill orifice is 0.02-0.5 millimeter.

8. ablation catheter according to claim 1, is characterized in that, described ablation member comprises multiple electrode, and the projection of the plurality of electrode on the cross section of the axis perpendicular to described ablation catheter is positioned at circumferentially same.

9. ablation catheter according to claim 1, is characterized in that, described wire leading pipe is located in described stay pipe, and the far-end of described intrusion pipe is located between described stay pipe and described wire leading pipe.

10. according to described ablation catheter arbitrary in claim 1 to 9, it is characterized in that, described ablation catheter also comprises the catheter main body of hollow, and described ablation member is located at the far-end of described catheter main body, and described intrusion pipe is from the proximal extension of described catheter main body to the near-end of described stay pipe.