CN203539434U - Multi-electrode ablation catheter - Google Patents
Multi-electrode ablation catheter Download PDFInfo
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- CN203539434U CN203539434U CN201320636919.0U CN201320636919U CN203539434U CN 203539434 U CN203539434 U CN 203539434U CN 201320636919 U CN201320636919 U CN 201320636919U CN 203539434 U CN203539434 U CN 203539434U
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Abstract
The utility model provides a multi-electrode ablation catheter. The multi-electrode ablation catheter comprises a remote section, a main body section and a control handle which are sequentially connected, wherein at least one part of the remote section has a peripheral configuration; the peripheral configuration can be reversibly changed into a lower outline configuration; a plurality of electrodes for ablation are arranged on the peripheral configuration; the multi-electrode ablation catheter is characterized in that the remote section is a multi-cavity tube; a guide wire is contained in one cavity; the remote section is straightened if the guide wire is introduced into the cavity; the remote section restores to the peripheral configuration if the guide wire is withdrawn. The peripheral configuration of the remote section can be adjusted according to the requirements, and the plurality of electrodes can be utilized to ablate a plurality of target spots, so as to form the ablation in an expected shape. The multi-electrode ablation catheter can be matched and used together with the marketed guide wire in suitable size, so as to conveniently deliver.
Description
The application is to be that April 12, application number in 2013 are that 201320185881.X and utility model name are called the dividing an application of Chinese patent application of " multi-electrode ablation catheter " applying date.
Technical field
This utility model relates to a kind of multi-electrode ablation catheter, melts, particularly a kind of multi-electrode ablation catheter that can be used for the treatment of renal artery denervation and pulmonary artery radio-frequency (RF) ablation for target site being carried out to multi-electrode electric discharge in body vessels.
Background technology
Intractable hypertension claims again refractory hypertension, refers to and adopts more than 3 kinds or 3 kinds antihypertensive drugs (comprising a kind of diuretic) to treat still out of contior hypertension.Up-to-date animal and clinical experiment digital proof: the method that adopts percutaneous catheter to carry out radio-frequency (RF) ablation to kidney sympathetic nerve can reduce hypertension lastingly effectively.
The method has conduit and gets involved means, can utilize radio-frequency (RF) energy to carry out impedance type heating to the sympathetic nerve at renal artery position, can weaken its activity and even make its conduction function lose.The method not only can effectively be treated intractable hypertension, and there is Wicresoft, without advantages such as significant complications.Industry is considered as breakthrough this method, is considered to treat the new method of intractable hypertension.
Traditional electrode, in order to reach darker depth of ablation, can be used higher ablation power clinically, easy in like this surperficial localized hyperthermia that forms of target spot, easily facilitates thrombosis, eschar, thereby affects safety and effectiveness, prolongation operating time, increase patient's misery.
In order to reach darker depth of ablation, can be in radio-frequency (RF) ablation, surrounding in radio-frequency electrode sprays infusion liquid equably, can make like this electrode reach higher power, can not increase fast its temperature, when guaranteeing therapeutic effect, can also prevent that target spot surface from forming localized hyperthermia simultaneously, reduce incrustation and thrombosed probability, improve safety and the effectiveness of operation.
Current distal section is spiral electrode ablation conduit, in view of it, can send swimmingly and enters vascular to target site and form around the melting of the required form of vascular inwall, and comes into one's own.It is spiral electrode ablation conduit that those skilled in the art have developed following multiple distal section.
Publication number is that the Chinese invention patent application of CN102198015A discloses a kind of retractable spiral laminar ring type electrode catheter, conduit and supporting sheath are collaborative to be used, the far-end of conduit is spiral stacked ring type, can fold narrowing of the ring and expansion by the flexible spiral of controlling of SMIS core bar, the SMIS core bar of the method need to have certain hardness, could control the folded narrowing of the ring of spiral and expansion.Between SMIS core bar and sheath, there is space, easily form herein thrombosis.Conduit in this application does not have infusion liquid perfusion functional, and cooling electrode and reduction electrode surface incrustation risk, can not ensure enough depth of ablation effectively.
Publication number is that the Chinese utility model patent application of CN201469401U discloses a kind of spiral renal-artery-around renal sympathetic nerve radio radio-frequency electrode conduit, and electrode is wherein continuous screw type, and this electrode is excessive, can not effectively guarantee depth of ablation.Electrode distal end, without special protective measures, easily causes renal artery perforation when conduit enters renal artery blood vessel, and risk is high.And without infusion liquid perfusion functional, incrustation risk is high.
Publication number is that the Chinese invention patent application of CN102488552A discloses a kind of spiral electrode conduit of controlling, the Chinese invention patent application that is CN102198015A with publication number is similar, this conduit is also controlled the contraction of conduit by SMIS core bar, without infusion liquid, pour into equally, can not effective cooling electrode.Between SMIS core bar and the main body of conduit, have space, between core bar and catheter main body, motion mutually, easily causes thrombosis.
Publication number is that the Chinese invention patent application of CN1549694A discloses a kind of electrophysiology device, it has spiral-shaped distal section, can in this distal section, arrange a plurality of electrodes, this distal section arranges its helical configuration by the core component wherein extending, and can reversibly be deformed into compared with low profile configuration, to send smoothly in vascular, but: it has only been mentioned and can use liquid coolant according to the feedback of temperature data, concrete infusion liquid filling mechanism is not disclosed, and the preferred spiral winding of the electrode in distal section, obviously, electrode itself cannot become a part for liquid coolant perfusion stream, cannot be from electrode take away heat everywhere, in addition, this electrophysiologicalcatheter catheter can only make for making distal section be deformed into compared with low profile configuration and then send in vascular smoothly with guiding catheter is collaborative, but while using with guiding catheter is collaborative, it can increase total outer circumference diameter, in very thin vascular, can increase the discomfort of sending difficulty and increasing patient.
Publication number is that the Chinese invention patent application of CN101309651A discloses a kind of multi-electrode ablation catheter, the electric discharge that is applicable to arteries and veins nozzle position is melted, this conduit can control electrode and the degree that reclines of target position, but there is gap in the center core bar and the catheter main body that in part-structure, have, easily causes thrombosis; This conduit does not have the function of infusion liquid perfusion yet.
Therefore, a kind of multi-electrode ablation catheter need to be provided, its distal section can reversibly change at helical configuration and between compared with low profile configuration, so that successfully send in vascular, and utilize a plurality of target spots place of a plurality of electrode pair vascular inwalls of arranging in distal section to melt, form melting of intended shape; And this conduit also has infusion liquid filling mechanism, its inner chamber that can effectively utilize electrode and conduit forms liquid coolant perfusion stream, takes away efficiently heat everywhere thus from electrode; In addition, this conduit can depending on applicable cases neatly selection and guiding catheter, seal wire, guiding sheath is collaborative uses to send smoothly in vascular; This conduit can also utilize joystick via traction fiber, to carry out the circle size of adjustable screw configuration in addition, while making in vascular need to be entered, can turn the diameter of helical configuration down, and can tune up the diameter of helical configuration near arriving target spot time, make electrode each target spot that closely reclines.In addition, sometimes need the target spot melting to be strictly limited in longitudinally in arrowband, this just needs the far-end of distal section to be connected with the multi-electrode ablation catheter of the adjustable annular ring of diameter, it also can successfully send in vascular, can utilize the approximate a plurality of target spots place dropping on a circle of a plurality of electrode pair vascular inwalls of arranging on annular ring to melt, form intended shape melting for annular.
Utility model content
This utility model provides a kind of multi-electrode ablation catheter, comprise the distal section, main paragraph and the joystick that are linked in sequence, the at least part of of described distal section is circumferential configuration, this circumferential configuration can reversibly be changed into compared with low profile configuration, and on it, be furnished with a plurality of electrodes that melt use, it is characterized in that: in main paragraph and joystick, be provided with infusion liquid passage; Described distal section comprises infusion liquid tube chamber, on the sidewall of described infusion liquid tube chamber, has opening; And each electrode has at least one fill orifice, circumferential fixed and arranged around described distal section, and and forming cavity between infusion liquid tube chamber, each fill orifice is connected to the infusion liquid source of conduit outside via described cavity, corresponding opening, described infusion liquid tube chamber, described infusion liquid passage fluid.Utilize this multi-electrode ablation catheter, can regulate as required the helical configuration of distal section, for example, when multiple electrode catheter will enter in vascular, can be changed into compared with low profile configuration and be convenient to enter smoothly vascular and sending wherein; And when being delivered to target position, can recover the helical configuration of distal section to implement to melt with the target position reclining on sidewall, guarantee depth of ablation and avoid the damage to perienchyma; And, can utilize a plurality of target spots place of a plurality of electrode pair vascular inwalls of arranging in distal section to melt, form melting of intended shape; And this conduit also has infusion liquid filling mechanism, its inner chamber that can effectively utilize electrode and conduit forms liquid coolant perfusion stream,, comprises inner and outer wall thus from electrode everywhere, takes away efficiently heat.
Described circumferential configuration can be taked various ways.Preferred two kinds of forms are: described distal section is helical configuration, or described distal section is loop configurations.
Preferably, described each electrode is evenly distributed on a week of described distal section part that presents circumferential configuration.Thus, can utilize each electrode that size is less to form the required shape that melts.
Preferably, the fill orifice on each electrode is with a row or multi-row layout, and the fill orifice in single is along being circumferentially evenly arranged, and adjacent row's fill orifice is and is staggered.Thus, infusion liquid can be filled into effectively to the regional of electrode surface via each fill orifice of distribution like this, thereby effectively realize the effect that cools of electrode.
Preferably, described distal section is multi-lumen tube, and the fixing fixed wire of the first intracavity wherein, in order to keep the circumferential configuration of distal section.The structure of this multi-lumen tube is convenient to utilize each chamber to hold respectively required member to avoid interfering with each other between member.For saving space meter, in the situation that guaranteeing that some members can not interfere with each other, for example wire and temperature sense line, also can together be contained in same intracavity by them.
Preferably, the nearside of described joystick is provided with connector conduit, and described in this, connector conduit is provided with the first female Luer, and described infusion liquid passage is connected to infusion liquid source via described connector conduit and the first female Luer.
Preferably, described fill orifice is prepared by a kind of mode in mechanical hole building, electric spark pore-forming, laser punching.Preferably, the diameter of described fill orifice is 0.02mm-0.5mm, and the quantity of fill orifice is 2-40.
This utility model also provides a kind of multi-electrode ablation catheter, comprise the distal section, main paragraph and the joystick that are linked in sequence, in described distal section, be furnished with a plurality of electrodes that melt use, it is characterized in that, described distal section is loop configurations, and described arrangement of electrodes is on the annular ring of described loop configurations.This design that is provided with the distal ports of annular ring, the strict limited situation of longitudinal extension of adaptation target spot, can dwindle the diameter of annular ring in the time of need to sending in vascular, and when needs closely recline vascular inwall, can expand the diameter of annular ring.
Preferably, the described distal section of above-mentioned two kinds of multi-electrode ablation catheters is multi-lumen tube, and wherein an intracavity holds traction fiber, and described joystick is coupled to described traction fiber, and under the adjusting of joystick, the diameter of helical configuration or annular ring changes.Thus, can utilize as required joystick accurately and the diameter of adjustable screw configuration or annular ring easily, for example, when multiple electrode catheter will enter in vascular, can turn diameter down and be convenient to enter smoothly vascular and sending wherein; And when the diameter of helical configuration or annular ring is less than the internal diameter of vascular and causes not being adjacent to the sidewall of vascular when being delivered to target spot position, can tune up the target position of diameter closely to recline on sidewall, guarantee depth of ablation and avoid the damage to perienchyma.
Preferably, the described distal section of above-mentioned two kinds of multi-electrode ablation catheters is multi-lumen tube, and wherein an intracavity holds seal wire, and passing into of seal wire stretched distal section, and withdrawing of seal wire makes distal section reply configuration, for example, reply helical configuration or reply loop configurations.Thus, this multi-electrode ablation catheter can be used in conjunction with the seal wire of applicable specification on the market, sends easily implementing.Preferably, the nearside of described joystick is provided with the second female Luer, and described seal wire passes into conduit via described the second female Luer, thus, can control flexibly seal wire.
This utility model also provides a kind of multi-electrode ablation catheter, comprise the distal section, main paragraph and the joystick that are linked in sequence, described distal section is helical configuration, can reversibly change into compared with low profile configuration, and on it, be furnished with a plurality of electrodes that melt use, it is characterized in that: described distal section is multi-lumen tube, and wherein an intracavity holds seal wire, passing into of seal wire stretched distal section, and withdrawing of seal wire makes distal section reply helical configuration.Thus, the multi-electrode ablation catheter that this distal section is helical configuration can be used in conjunction with the seal wire of applicable specification on the market, sends easily implementing.
Accompanying drawing explanation
In order more clearly to describe the technical solution of the utility model, below in conjunction with accompanying drawing, briefly introduce.Obviously, these accompanying drawings are only some specific embodiment that the application records.According to of the present utility model, include but not limited to following these accompanying drawings.Hereinafter, take away from operator is distally near a side of target spot, near operator's a side, is nearside.
Compared with low profile configuration, represent more to approach linear configuration, for example the helical configuration of minor diameter or the mutually larger-diameter helical configuration of regulable ring-shaped circle or regulable ring-shaped circle are respectively low profile configurations, and it is low profile configuration that the configuration of helical configuration under (comprise and the stretching) state of stretching compared original helical configuration.Circumferentially configuration expression is along the configuration of circumferential extension, and it has various ways, and for example distal section is helical configuration or loop configurations.Loop configurations represents the configuration that straight portion and annular ring are formed by connecting, and the quantity of annular ring and position can be determined as required.In the situation that distal section is helical configuration, the spiral part that represents a pitch of this helical configuration for one week that presents the described distal section part of circumferential configuration, and in the situation that described distal section is loop configurations, present an annular ring of expression in a week of the described distal section part of circumferential configuration.
Annular electrode represents that this electrode is for the revolving body along axial two open ends and hollow, and this revolving body can be straight tube, also can have the periphery of fluctuating, can also in far and near both sides, carry out chamfering as required.In addition, term " fluid connection " represents to connect in mode that can transmitting fluid, the parts of for example two " fluid connection ", the transmission of can flowing between two parts of expression fluid.
Fig. 1 illustrates according to the multi-electrode ablation catheter of this utility model one embodiment, and it can pass into seal wire and also possess infusion liquid perfusion functional;
Fig. 2 illustrates the diagram that Fig. 1 sees along an a-a alignment left side;
Fig. 3 illustrates a kind of schematic diagram with the annular electrode of boss;
Fig. 4 illustrates fixed form between the annular electrode shown in Fig. 3 and the distal section of conduit and the schematic diagram of infusion liquid stream;
Fig. 5 A illustrates the schematic diagram of a kind of annular electrode of straight tube and the fill orifice distribution on surface thereof;
Fig. 5 B illustrates the schematic diagram of the annular electrode of another kind of straight tube and the fill orifice distribution on surface thereof;
Fig. 5 C illustrates the schematic diagram of the annular electrode of another straight tube and the fill orifice distribution on surface thereof;
Fig. 6 illustrates fixed form between the annular electrode of straight tube and the distal section of conduit and the schematic diagram of infusion liquid stream;
Fig. 7 illustrates the schematic diagram that the multi-electrode ablation catheter shown in Fig. 1 passes into seal wire front and back;
Fig. 8 illustrates Fig. 7 along the profile of b-b line;
Fig. 9 illustrate according to this utility model one embodiment can with the schematic diagram of the collaborative multi-electrode ablation catheter using of guiding catheter;
Figure 10 illustrate according to this utility model one embodiment can with the schematic diagram of the collaborative multi-electrode ablation catheter using of seal wire;
Figure 11 illustrates according to the schematic diagram of the multi-electrode ablation catheter with infusion liquid perfusion functional of this utility model one embodiment;
Figure 12 be illustrated on the basis of the multi-electrode ablation catheter shown in Figure 11, add the multi-electrode ablation catheter of the mechanism's gained for the helical configuration of the distal section of multi-electrode ablation catheter is regulated and regulate before and after schematic diagram;
Figure 13 illustrates the diagram of seeing along a c-c alignment left side in Figure 12;
Figure 14 illustrates in Figure 12 the profile along d-d line;
Figure 15 illustrates the schematic diagram according to the multi-electrode ablation catheter that is provided with the helical configuration governor motion shown in Figure 12 of this utility model one embodiment and before and after regulating, and this multi-electrode ablation catheter and guiding catheter are collaborative to be used;
Figure 16 illustrates the multi-electrode ablation catheter that is provided with the helical configuration governor motion shown in Figure 12 of this utility model one embodiment and regulates the schematic diagram of front and back, this multi-electrode ablation catheter can optionally be worked in coordination with and use with guiding catheter or seal wire, and has infusion liquid perfusion functional;
Figure 17 illustrates the multipole ablation catheter of annular ring configuration governor motion and the schematic diagram of adjusting front and back of this utility model one embodiment;
Figure 18 illustrates the diagram of seeing along an e-e alignment left side in Figure 17.
The specific embodiment
In order further to understand this utility model, below in conjunction with embodiment, preferred version of the present utility model is described.These descriptions just illustrate feature and advantage of the present utility model, and unrestricted protection domain of the present utility model.
Fig. 1 shows can admittance silk and with the multi-electrode ablation catheter of infusion liquid perfusion functional according to this utility model one embodiment a kind of, it comprises that be linked in sequence at least part of is the distal section 1 of circumferential configuration, main paragraph 4 and joystick 6, wherein, under the effect of power outside of the circumferential configuration of distal section 1, such as inserting the intracavity of guiding catheter or reversibly changing into compared with low profile configuration via passing into seal wire 22, for example stretched, to more successfully enter vascular and be delivered to target position.This circumferential configuration can be taked various ways, and for example, described distal section 1 can be helical configuration or loop configurations, utilizes the one or more annular rings in this helical configuration or loop configurations to form described circumferential configuration.As an example of loop configurations, the far-end of described distal section 1 is provided with (being for example connected with) annular ring, and this annular ring preferably diameter is adjustable.Following elder generation take distal section 1 and describes as helical configuration as example, but those skilled in the art will know that, other forms of can to change under external force compared with the circumferential configuration along circumferential extension of low profile configuration be also available, and below what in distal section 1, also can correspondingly be applicable to distal section 1 for various structures applicable in helical configuration situation is the situation of other forms of circumferential configuration at least partly.
In this distal section, be furnished with at least one electrode 2 for target spot is melted, each electrode 2 is at least in part around the circumferential fixed and arranged of described distal section.Each electrode 2 can be taked various annulars thus around the circumferential fixed and arranged of described distal section, and for example, stage casing is as shown in Figure 3 provided with the annular electrode 201 of boss and the annular electrode 209 of the straight tube as shown in Fig. 5 A-5C etc.According to concrete applicable cases, each electrode 2 also can adopt the annular of part.Wherein, on electrode 2, can have at least one fill orifice 3, melt in vivo when for example carrying out renal artery denervation radio-frequency (RF) ablation, can carry out infusion liquid perfusion via filling mechanism, described filling mechanism is constructed as follows: in main paragraph and joystick, be provided with infusion liquid passage; Described distal section comprises that infusion liquid tube chamber 102(is as shown in Fig. 8 and Figure 14), on the sidewall of described infusion liquid tube chamber 102, there is opening; And between each electrode 2 and infusion liquid tube chamber 102, forming cavity ( perfusion sap cavity 202 and 208 as shown in Figure 4 and Figure 6), each fill orifice 3 is connected to the infusion liquid source of conduit outside via described perfusion sap cavity 202, corresponding opening (opening 211 and 221 as shown in Figure 4 and Figure 6), described infusion liquid tube chamber 102, described infusion liquid passage fluid.By utilizing this filling mechanism, infusion liquid can be transported to perfusion sap cavity 202 from infusion liquid source via described infusion liquid passage, infusion liquid tube chamber 102 and opening, and accumulate therein, during accumulating, from inwall, absorb the heat of electrode 2, while being full of, from fill orifice 3, spray infusion liquid, the outer wall of electrode is washed away with cooling, thereby can more effectively to electrode 2, carry out cooling and take away efficiently heat everywhere from it, more powerful energy can be on electrode 2, inputted thus, thereby the degree of depth of electrode ablation can be guaranteed.
The distal section 1 of described helical configuration can be multi-lumen tube, infusion liquid tube chamber 102 is a chamber wherein, in other each chambeies, can hold respectively required parts, one or more in traction fiber, seal wire, wire, fixed wire and temperature sense line for example, also can be in the situation that not affecting separately operation, by multiple parts, for example wire and temperature sense line are contained in identical intracavity.This multi-lumen tube can be prepared by materials such as the block copolymer of polyurethane, polyethers and polyamide, nylon, and the quantity in the chamber of multi-lumen tube is 1-6, and preferably the quantity in chamber is 2-5.This utility model be take four lumens as the applicable cases of example introduction in multi-electrode ablation catheter, and the diameter of multi-lumen tube is 0.9-3.0mm, and this four chamber is guidewire lumen 103, fixed wire tube chamber 104, infusion liquid tube chamber 102 and guidewire lumen 105.In described fixed wire tube chamber 104, be fixed with fixed wire 12 in order to keep the shape of helical configuration, this fixed wire 12 can be by preparing containing the materials such as block copolymer silk of titanium-nickel wire, stainless steel silk, polyurethane filament, polyethers silk, polyamide.Guidewire lumen 103 in the distal section 1 of this helical configuration is interior can pass into seal wire 22, can use with seal wire 22 is collaborative, so that multi-electrode ablation catheter is delivered to the target position in body vessels according to the multi-electrode ablation catheter of an embodiment of this utility model.For example, first seal wire 22 is entered in renal artery blood vessel via femoral artery routine, then this multi-electrode ablation catheter is delivered to the target position of renal artery blood vessel along seal wire 22.Multi-electrode ablation catheter passes into the schematic diagram of seal wire 22 front and back and sees Fig. 7.
The electrode 2 of arranging in the distal section of this helical configuration can be 1-15, and preferred electrode number is 4-10.Electrode 2 can be prepared by materials such as platinumiridio, gold, silver, platinum, copper, rustless steels, fill orifice 3 on electrode 2, shown in fill orifice D as shown in Figure 4 and Figure 6, can optionally by a kind of mode in mechanical hole building, electric spark pore-forming, laser punching, prepare.On each electrode 2, be connected with wire 13, near electrode 2, be provided with the heat sensor of the temperature of electrode while melting for perception electric discharge, this heat sensor is connected to the temperature sense line 14 in guidewire lumen 105, wire 13 and temperature sense line 14 are connected on the buttock line socket 7 of joystick 6 near-ends after the distal section 1 of helical configuration and main paragraph 4, be respectively used to transmit the signal of telecommunication and/or pulsed radio-frequency power and temperature feedback signal, thereby can greatly improve the safety in utilization of this ablation catheter.
The main paragraph 4 of multi-electrode ablation catheter is that the tubing that braided wires and Polymer materialspreparation form forms, one or more in the block copolymer silk that this braided wires comprises titanium-nickel wire, stainless steel silk, polyurethane filament, polyethers silk, polyamide, and establishment silk can be monolayer braided wires or multilamellar establishment silk; This macromolecular material is selected from the materials such as the block copolymer, nylon of polyurethane, polyethers and polyamide.Joystick 6 grips for patient, can be by polypropylene (PP), the material preparations such as polyethylene (PE), silica gel, rubber, polyformaldehyde (POM), polrvinyl chloride (PVC), copolyester (PETG), polystyrene (HIPS), acrylonitrile-butadiene-styrene (ABS) plastics (ABS), be connected with main paragraph 1, for conduit is carried out to various control.Joystick 6 near-ends can have buttock line socket 7, and this buttock line socket 7 is for connecting radiofrequency generator by supporting buttock line.Joystick 6 near-ends can be provided with connector conduit 9, and this connector conduit 9 connects respectively female Luer 8 and female Luer 10.Described female Luer 8 is connected to infusion liquid 11 for fluid, infusion liquid 11 enters in multi-electrode ablation catheter from female Luer 8, pass through successively connector conduit 9, the interior infusion liquid passage of joystick 6 (not indicating in figure) enters main paragraph 4, then, shown in Figure 4, enter the infusion liquid tube chamber 102 in the distal section 1 of helical configuration, then infusion liquid 11 enters infusion liquid chamber 202 after multi-lumen tube sidewall opening 211, finally from fill orifice 203, eject, stage casing has in the perfusion sap cavity 202 in the annular electrode 201 of boss and is full of infusion liquid 11, and constantly eject, take away a large amount of heats, can effectively take away the energy of electrode, reduce the temperature of electrode, also reduced the risk of electrode surface incrustation.Infusion liquid can be selected the liquid coolant to human-body safety, such as cool brine etc.
As shown in Figure 2, from Fig. 1, look left vertically, it is upper that the helical configuration of distal section 1 is stacked in circle, and this diameter of a circle is 3-30mm.All electrodes 2 are evenly distributed on a week of helical configuration.When the quantity of electrode 2 is 4, in Fig. 2, electrode 2 is evenly distributed on round periphery, and adjacent both angles are 90 °.Preferably, fill orifice 3 is along being circumferentially evenly distributed on the surface of each electrode 2.When the quantity of electrode 2 surpasses 4, electrode 2 is also evenly distributed on round periphery, and in Fig. 2, the angle between electrode 2 can be for multiple, quantity by 360 °/electrode 2 obtains its number of degrees, and wherein typical angle comprises 72 °, 60 °, 45 ° and 40 ° etc.Above-described angle is typical angle, but situation described in the utility model is not limit above-described several situation, is still applicable to similarly other angles.
Fig. 3 illustrates a kind of schematic diagram with the annular electrode 201 of boss.The described annular electrode 201 with boss comprises bottom 204, boss portion 207 and the excessive portion 205 that is connected both, and be distributed in the fill orifice 203 in boss portion 207, this fill orifice 203 can connect the sidewall of boss portion 207, between the sidewall of boss portion 207 and infusion liquid tube chamber 102, form perfusion sap cavity 202 as shown in Figure 4, each fill orifice 203 is via described perfusion sap cavity 202 thus, corresponding opening (opening 211 as shown in Figure 4), described infusion liquid tube chamber 102, described infusion liquid passage fluid is connected to the infusion liquid source of conduit outside, to utilize the infusion liquid of carrying, pour into.The quantity of the fill orifice 203 on the described annular electrode 201 with boss is at least 1, fill orifice 203 quantity on the annular electrode with boss 201 described in Fig. 3 are 6, being divided into two rows distributes, each row is uniformly distributed circumferentially 3 fill orifices 203, this two irrigation and drainage orifice 203 is and is staggered, as shown in Figure 3.Infusion liquid can be filled into effectively to the regional of electrode surface via each fill orifice, thereby effectively realize the effect that cools of electrode.Fill orifice 203 quantity of the annular electrode with boss 201 shown in Fig. 3 and row be only for example, and the quantity of described fill orifice 203 can be the arbitrary quantity in 2-40, and row can be the arbitrary quantity in 2-6 row.The diameter of described fill orifice 203 is 0.02-0.5mm, and preferably, the diameter of described fill orifice is 0.08-0.2mm.
Fig. 5 A illustrates the schematic diagram of a kind of annular electrode of straight tube and the fill orifice distribution on surface thereof.On described annular electrode 209, have two irrigation and drainage orifices 210, each row is uniformly distributed circumferentially 3 fill orifices 210, and this two irrigation and drainage orifice 210 is and is staggered.Fig. 5 B illustrates the schematic diagram of the annular electrode of another kind of straight tube and the fill orifice distribution on surface thereof.On described annular electrode 214, have two irrigation and drainage orifices 210, each row is uniformly distributed circumferentially 4 fill orifices 210, and this two irrigation and drainage orifice 210 is and is staggered.Fig. 5 C illustrates the schematic diagram of the annular electrode of another straight tube and the fill orifice distribution on surface thereof.On described annular electrode 213, have three irrigation and drainage orifices 210, each row is uniformly distributed circumferentially 3 fill orifices 210, and 210 of the fill orifices of any two the adjacent rows in this three irrigation and drainage orifice 210 are and are staggered.As shown in Figure 5 C, between adjacent row's fill orifice 210, along 60 degree that circumferentially stagger, first row and the 3rd row's fill orifice 210 is upwards alignd in week.
Fill orifice on annular electrode shown in Fig. 5 A-5C is arranged as example of the present utility model, also can take as required the arrangement of the fill orifice of other quantity in 2-40.Preferably, fill orifice on each electrode is with a row or multi-row layout, fill orifice in single is along being circumferentially evenly arranged, and adjacent row's fill orifice is and is staggered, can in a plurality of lengthwise positions, from the circumferential a plurality of angle positions of electrode, spray equably infusion liquid like this, to take away equably heat everywhere from electrode.On annular electrode along with the increase of fill orifice quantity, the corresponding fill orifice diameter that reduces.Otherwise, on annular electrode along with the increase of fill orifice diameter, corresponding minimizing fill orifice quantity.Preferably, on annular electrode, the quantity of fill orifice is 4-20, is divided into a row or multi-row arrangement.Can prepare the fill orifice on annular electrode by modes such as mechanical hole building, electric spark pore-forming, laser punchings, the diameter of described fill orifice is 0.02mm-0.5mm, and preferably, the diameter of described fill orifice is 0.08-0.2mm.
Fig. 4 illustrates fixed form between the annular electrode shown in Fig. 3 and the distal section of conduit and the schematic diagram of infusion liquid stream.The annular electrode 201 with boss is secured together with multi-lumen tube 101, the bottom 204 with the annular electrode of boss contacts with multi-lumen tube 101, both contacts site are realized both by thermal weld, glue or mechanical system and are sealed fixing, boss portion 207, between specifically its inwall, and multi-lumen tube 101, form perfusion sap cavity 202.Wherein on the sidewall of the infusion liquid tube chamber 102 in multi-lumen tube 101, there is opening 211, infusion liquid 11 is from female Luer 8(as shown in Figure 1) enter multi-electrode ablation catheter, the distal section 1(multi-lumen tube 101 that enters helical configuration through the infusion liquid passage in multi-electrode ablation catheter (not indicating in Fig. 1)) the infusion liquid tube chamber 102 in, infusion liquid 11 enters multi-lumen tube 101 along the flow direction of arrow " A " indication, after the opening 211 on the sidewall of infusion liquid tube chamber 102, infusion liquid 11 is divided into both direction, a part continues distad to flow along infusion liquid tube chamber 102, as shown in arrow " C ", another part enters chamber 202 along the flow direction of arrow " B " indication via sidewall opening 211.Infusion liquid 11 is filled with perfusion sap cavity 202, flows out, from 6 fill orifices 203 that have the annular electrode 201 of boss as shown in the arrow in Fig. 4 " D ".Infusion liquid 11 constantly enters perfusion sap cavity 202, and from fill orifice 203, flow out or ejection after being full of perfusion sap cavity 202, in the process that infusion liquid 11 is accumulated in perfusion sap cavity 202, the inwall from annular electrode 201 absorbs heat constantly, and can wash away cooling to the outer wall of annular electrode 201 from fill orifice 203 flows out or sprays, thus can be from thering is the inside and outside heat that absorbs fully of the annular electrode 201 of boss, can effectively reduce the temperature of the annular electrode 201 with boss, can increase electric discharge ablation power, improve depth of ablation, and reduce electrode surface incrustation risk.
Fig. 6 illustrates fixed form between the annular electrode of straight tube and the distal section of conduit and the schematic diagram of infusion liquid stream.The annular electrode 209 of this straight tube is substantially straight tube shape except the edge (shown in oblique line) of both sides, together with being affixed to multi-lumen tube 101.By glue or hot linked mode, 101 sealings of the both sides of the edge of annular electrode 209 and multi-lumen tube are fixing, the outer wall of the infusion liquid tube chamber 102(in the middle part (inwall) that makes annular electrode 209 and multi-lumen tube 101) between, form and pour into sap cavity 208.With situation shown in Fig. 4 similarly, infusion liquid 11 enters after infusion liquid tube chamber 102, along arrow " A " indicated direction, flow, opening 212 on infusion liquid tube chamber 102 sidewalls is punished into both direction: a part continues distad to flow along infusion liquid tube chamber 102, as shown in the arrow in Fig. 6 " C ", another part flows into perfusion sap cavity 208 via sidewall opening 212 along arrow " B " indicated direction, infusion liquid is filled with after perfusion sap cavity 208, fill orifice 206 from annular electrode 209 flows out, as shown in the arrow in Fig. 6 " D ".Infusion liquid 11 in perfusion sap cavity in 208 processes of accumulating constantly the inwall from annular electrode 209 absorb heat, and can wash away cooling to the outer wall of annular electrode 209 from fill orifice 206 flows out or sprays, thus can be from thering is the inside and outside heat that absorbs fully of the annular electrode 209 of straight tube, can effectively reduce the temperature of the annular electrode 209 with straight tube, can increase electric discharge ablation power, improve depth of ablation, and reduce electrode surface incrustation risk.
Fig. 7 illustrates the schematic diagram that the multi-electrode ablation catheter shown in Fig. 1 passes into seal wire front and back.Described multi-electrode ablation catheter has infusion liquid perfusion functional, can be used in conjunction with the guiding catheter that is applicable on the market specification, also can be used in conjunction with the seal wire that is applicable on the market specification, multi-electrode ablation catheter is transported to the target spot position of vascular in human body.Multi-electrode ablation catheter passes into after seal wire 22, and the main body of seal wire 22 provides support power, and 1 support of the distal section of the helical configuration of multi-electrode ablation catheter is straight, as shown in the dashed line view in Fig. 7.Seal wire 22 enters multi-electrode ablation catheter from female Luer 10, then enters the silk guide passage (not indicating in figure) in multi-electrode ablation catheter, and the far-end of silk guide passage is provided with opening can be for the far-end pass-out of seal wire.The surface of seal wire 22 has superslide coating, make seal wire 22 can the silk guide passage in multi-electrode ablation catheter in smooth and easy passing through.Like this, multi-electrode ablation catheter can be by seal wire 22 by multi-electrode ablation catheter successfully by the target position of femoral artery vascular in retrograde blood enters human body, these target positions include but not limited to renal artery blood vessel, pulmonary artery etc.When seal wire 22 enters vascular, seal wire 22 far-ends are provided with the extraordinary seal wire stretch section 21 of compliance, can enter in body vessels very smoothly, and can not damage vascular tissue.The near-end 23 of seal wire can be fixed, so that seal wire 22 positions after entering body vessels.Behind the location, target spot place of distal section 1 vascular in human body of helical configuration, clamping seal wire near-end 23 withdraws seal wire 22, the distal section 1 of helical configuration is reverted back to spiral-shaped, so that electrode 2 abuts in the target position in vascular effectively.
Fig. 8 illustrates Fig. 7 along the profile of b-b line.As shown in Figure 8, multi-lumen tube 101 comprises four chambeies, is respectively infusion liquid tube chamber 102, guidewire lumen 103, fixed wire tube chamber 104 and guidewire lumen 105.Wherein, described infusion liquid tube chamber 102 is as a part for infusion liquid stream, for transmitting infusion liquid; Guidewire lumen 103, for passing into seal wire, arrives the target position of body vessels to guide multi-electrode ablation catheter; In fixed wire tube chamber 104, be fixed with fixed wire, for keeping the helical configuration of distal section 1, the material of fixed wire can be selected from but be not limited to the materials such as block copolymer silk of titanium-nickel wire, stainless steel silk, polyurethane filament, polyethers silk, polyamide; In guidewire lumen 105, hold wire 13 and temperature sense line 14, wire 13 and temperature sense line 14 are affixed on the pin of buttock line socket 7 correspondences successively after main paragraph 4 and joystick 6, to transmit the signal of telecommunication and carry radio-frequency pulse energy.
Fig. 9 illustrate according to this utility model one embodiment can with the schematic diagram of the collaborative multi-electrode ablation catheter using of guiding catheter, its distal section that comprises helical configuration 1 and around a plurality of electrodes 2, main paragraph 4, handle function part 5, joystick 6 and the buttock line socket 7 of its layout.Described multi-electrode ablation catheter can be used in conjunction with guiding catheter, guiding catheter first arrives the target position place in vascular, described multi-electrode ablation catheter arrives after target position by guiding catheter, fixing multi-electrode ablation catheter, withdraw guiding catheter, the distal section 1 of multi-electrode ablation catheter 1 is replied after helical configuration, and the electrode 2 in the distal section 1 of helical configuration clings to the target position on vascular.Then can carry out signal extraction to target position, and transport pulse radio-frequency (RF) energy, realize electric discharge ablation functionality.
Figure 10 be illustrate according to this utility model one embodiment can with the schematic diagram of the collaborative multi-electrode ablation catheter using of seal wire, its distal section that comprises helical configuration 1 and around a plurality of electrodes 2, main paragraph 4, handle function part 5, joystick 6, buttock line socket 7 and the female Luer 10 of its layout.Described multi-electrode ablation catheter contains silk guide passage (not indicating in figure), passes into after seal wire 22 in multi-electrode ablation catheter, and seal wire 22 can be straight by 1 support of the distal section of helical configuration.The target position that seal wire 22 arrives in vascular, then multi-electrode ablation catheter arrives after target position along seal wire 22, withdraws seal wire 22, and distal section 1 reverts back to helical configuration, makes electrode paste lean on target position.Then can carry out signal extraction to target position, and transport pulse radio-frequency (RF) energy, realize electric discharge ablation functionality.
Figure 11 illustrates according to the schematic diagram of the multi-electrode ablation catheter with perfusion of saline function of this utility model one embodiment, its distal section that comprises helical configuration 1, a plurality of electrodes 2 of arranging around distal section 1, fill orifice 3, main paragraph 4, handle function part 5, joystick 6, buttock line socket 7, female Luer 8 and the connector conduit 9 on each electrode 2.In described main paragraph 4 and joystick 6, be provided with infusion liquid passage (not indicating in figure), from the infusion liquid in infusion liquid source after female Luer 8, by infusion liquid passage, enter the distal section 1 of helical configuration, then enter the interior (see figure 4) of perfusion sap cavity 202 of inwall and the infusion liquid tube chamber 102 of electrode 2, finally by crossing fill orifice 203, flow out electrode 2, infusion liquid 11 can be from the inside and outside heat of taking away efficiently electrode 2, thereby can increase the power on electrode 2, increase the depth of ablation of target position.
Figure 12 be illustrated on the basis of the multi-electrode ablation catheter shown in Figure 11, add the multi-electrode ablation catheter of the mechanism's gained for the helical configuration of the distal section of multi-electrode ablation catheter is regulated and regulate before and after schematic diagram.The distal section 1 that this multi-electrode ablation catheter comprises helical configuration, electrode 2, fill orifice 3, main paragraph 4, handle function part 5, joystick 6, buttock line socket 7, female Luer 8 and connector conduit 9.Wherein said handle function part 5 is for controlling the diameter of the helical configuration of distal section 1, be convenient to the size of multi-electrode ablation catheter adjustable screw circle, so that multi-electrode ablation catheter can conveniently enter vascular in human body, and electrode can be clinged in blood vessel wall effectively.As shown in figure 13, in Figure 12, along a c-c alignment left side, see, the distal section 1 of helical configuration is projected on same circumference 16 in the axial direction, and the projection of electrode 2 is distributed on circumference 16 equably, and fill orifice 3 is arranged on electrode 2 according to certain rules.Traction fiber 15 is contained in the traction fiber chamber 103 of multi-lumen tube 101 (as shown in figure 14), and is coupled to the handle function part 5 on joystick 6, and traction fiber 15 is controlled the diameter of the helical configuration of distal section 1 by handle function part 5.
Utilize handle function part 5 to regulate after the diameter of helical configuration of distal section 1, the distal section 1 of helical configuration is also projected in a circumference 17(in the axial direction referring to shown in dotted line) on.Can utilize as required handle function part 5 that the diameter of the helical configuration of distal section 1 is turned down or tuned up.The diameter of helical configuration is convenient to multi-electrode ablation catheter and is entered body vessels after turning down, the distal section 1 of being convenient to helical configuration after tuning up clings in vascular in blood vessel wall in human body, and the electrode 2 in multi-lumen tube 101 can cling to the target spot in blood vessel wall effectively.Discharge while melting, multi-electrode ablation catheter shown in Figure 12 can pour into infusion liquid from infusion liquid source from female Luer 8 and connector conduit 9, the infusion liquid finally fill orifice from electrode 23 flows out, effectively reduce the temperature of electrode 2 and target spot tissue, can improve ablation power, increase the depth of ablation to tissue.
Figure 15 and Figure 16 show respectively the schematic diagram according to the multi-electrode ablation catheter that is provided with the helical configuration governor motion shown in Figure 12 of two embodiment of this utility model and before and after regulating, wherein, multi-electrode ablation catheter shown in Figure 15 can be used with guiding catheter is collaborative, and the multi-electrode ablation catheter shown in Figure 16 not only can be used with guiding catheter is collaborative, can also use with seal wire is collaborative, and there is infusion liquid perfusion functional.
Above only take Fig. 9 as exemplified a kind of can with the collaborative multi-electrode ablation catheter using of guiding catheter, but need to know, above those can with the collaborative multi-electrode ablation catheter using of seal wire, can be with the guiding catheter of appropriate size collaborative use.Operator can, according to the suitability of the seal wire of operation demand and appropriate size and guiding catheter and cost etc., select a kind of multi-electrode ablation catheter of assisting to send location.
In distal section 1, be various structures applicable in helical configuration situation above, especially the structure structure relevant with traction fiber that seal wire is relevant also can be respectively or be applicable in combination at least part of of distal section 1 is the situation of other forms of circumferential configuration, the situation that for example distal section 1 is loop configurations, in the case, a plurality of electrode 2 that melts use is arranged on the annular ring of described loop configurations.A kind of loop configurations that the far-end of distal section 1 of take is below connected with a regulable ring-shaped circle describes as example.
Figure 17 shows according to the far-end of the distal section 1 of this utility model one embodiment and is connected with the schematic diagram that a regulable ring-shaped circle and a plurality of electrode 2 that melts use are distributed in the multi-electrode ablation catheter in annular ring, wherein the schematic diagram of annular ring shown in broken lines after turning down.In the present embodiment, the junction of the far-end of annular ring and conduit can be arranged on the edge of annular ring, and in addition, the junction of the far-end of annular ring and conduit also can be arranged on the center of annular ring, and this connected mode is also in scope of the present utility model.Shape after the annular ring of illustrated embodiment is turned down is shown in Figure 17 and 18 shown in dotted line.Number of electrodes in this embodiment is 10, is more applicable to melting of the body lumen larger with vascular diameter.The annular ring of this embodiment can regulate its loop size, can coordinate guiding catheter to enter in body vessels, particularly orifices of pulmonary veins, pulmonary orifice, renal artery ostium and pulmonary vein, pulmonary artery, renal artery blood vessel etc. partly melt, not only improve and melt efficiency, this sizable design of annular ring can cling to ablating electrode target spot position more effectively, guarantees ablation effect.In addition, far-end is connected with the design of multi-electrode ablation catheter of adjustable annular ring except the scheme that this embodiment provides, can also with scheme shown in various embodiment in seal wire haulage gear and filling mechanism in any one or two kinds ofly use in combination.With regard to seal wire haulage gear, described distal section is multi-lumen tube, and wherein an intracavity holds seal wire, and passing into of seal wire makes distal section comprise that annular ring stretches, the withdrawing of seal wire make distal section reply configuration namely far-end be connected with the original configuration of annular ring.The diameter adjustment mechanism of this annular ring is to above the relevant regulatory mechanism for helical configuration is similar with Figure 12-14, also be following realization: traction fiber 15 is contained in the traction fiber chamber 103 of multi-lumen tube 101 (as shown in figure 14), and being coupled to the handle function part 5 on joystick 6, traction fiber 15 is controlled the diameter of the regulable ring-shaped circle of distal section 1 by handle function part 5.
This utility model is not limited to the particular content described in the specific embodiment.The conduit of a kind of interior therapeutic provided by the utility model melts in ablation arrhythmia and renal artery sympathetic nerve treatment hypertension purposes in heart, the electric discharge ablative surgery of body vessels such as is also suitable in other intracardiac and/or blood vessels.
The explanation of above embodiment is just for helping to understand core concept of the present utility model.Should be understood that; for the ordinary skill in the art; do not departing under the prerequisite of this utility model principle, can also carry out some improvement and modification to this utility model, but these improvement and modify also fall in the scope that this utility model claim asks for protection.
Claims (7)
1. a multi-electrode ablation catheter, comprise the distal section, main paragraph and the joystick that are linked in sequence, at least part of of described distal section is circumferential configuration, and this circumferential configuration can reversibly be changed into compared with low profile configuration, and on it, be furnished with a plurality of electrodes that melt use, it is characterized in that:
Described distal section is multi-lumen tube, and wherein an intracavity holds seal wire, and passing into of seal wire stretched distal section, and withdrawing of seal wire makes distal section reply circumferential configuration.
2. multi-electrode ablation catheter according to claim 1, is characterized in that: an intracavity of described distal section holds traction fiber, and described joystick is coupled to described traction fiber, and under the adjusting of joystick, circumferentially the diameter of configuration changes.
3. multi-electrode ablation catheter according to claim 1 and 2, is characterized in that, described distal section is helical configuration, or described distal section is loop configurations.
4. multi-electrode ablation catheter according to claim 1 and 2, is characterized in that, described each electrode is evenly distributed on a week of described distal section part that presents circumferential configuration.
5. multi-electrode ablation catheter according to claim 3, is characterized in that, when distal section is helical configuration, described each electrode is evenly distributed on a week of described helical configuration; And when distal section is loop configurations, described each distribution of electrodes is on the annular ring of described loop configurations.
6. multi-electrode ablation catheter according to claim 1 and 2, is characterized in that, described distal section is multi-lumen tube, and the fixing fixed wire of the first intracavity wherein, in order to keep the circumferential configuration of distal section.
7. multi-electrode ablation catheter according to claim 1 and 2, is characterized in that, the nearside of described joystick is provided with the second female Luer, and described seal wire passes into conduit via described the second female Luer.
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| CN201320636919.0U CN203539434U (en) | 2013-04-12 | 2013-04-12 | Multi-electrode ablation catheter |
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| CN201320636919.0U CN203539434U (en) | 2013-04-12 | 2013-04-12 | Multi-electrode ablation catheter |
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| CN201320185881XU Division CN203280485U (en) | 2013-04-12 | 2013-04-12 | Multi-electrode ablation catheter |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014166436A1 (en) * | 2013-04-12 | 2014-10-16 | 上海微创电生理医疗科技有限公司 | Multi-electrode ablation catheter |
| CN105286986A (en) * | 2014-07-30 | 2016-02-03 | 上海微创电生理医疗科技有限公司 | Catheter ablation device and electrode radiofrequency ablation catheter thereof |
| EP3037034A1 (en) * | 2014-12-22 | 2016-06-29 | Biosense Webster (Israel) Ltd. | Balloon for ablation around pulmonary veins |
| CN106861045A (en) * | 2017-03-30 | 2017-06-20 | 苏州景昱医疗器械有限公司 | Extension wire and the Implanted medical system including the extension wire |
| US10638976B2 (en) | 2016-04-28 | 2020-05-05 | Biosense Webster (Israel) Ltd | Method of constructing irrigated balloon catheter |
| US10653480B2 (en) | 2016-04-28 | 2020-05-19 | Biosense Webster (Israel) Ltd. | Method for constructing irrigated balloon catheter with flexible circuit electrode assembly |
| USD968422S1 (en) | 2019-05-31 | 2022-11-01 | Biosense Webster (Israel) Ltd. | Display screen with transitional graphical user interface |
| USD968421S1 (en) | 2019-05-31 | 2022-11-01 | Biosense Webster (Israel) Ltd. | Display screen with a graphical user interface |
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| US11957852B2 (en) | 2021-01-14 | 2024-04-16 | Biosense Webster (Israel) Ltd. | Intravascular balloon with slidable central irrigation tube |
| US11963715B2 (en) | 2022-07-18 | 2024-04-23 | Biosense Webster (Israel) Ltd. | Balloon-in-balloon irrigation balloon catheter |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2014166436A1 (en) * | 2013-04-12 | 2014-10-16 | 上海微创电生理医疗科技有限公司 | Multi-electrode ablation catheter |
| CN105286986A (en) * | 2014-07-30 | 2016-02-03 | 上海微创电生理医疗科技有限公司 | Catheter ablation device and electrode radiofrequency ablation catheter thereof |
| CN105286986B (en) * | 2014-07-30 | 2018-07-10 | 上海微创电生理医疗科技股份有限公司 | Catheter ablation device and its electrode radio-frequency ablation catheter |
| EP3932304A1 (en) * | 2014-12-22 | 2022-01-05 | Biosense Webster (Israel) Ltd. | Balloon for ablation around pulmonary veins |
| EP3037034A1 (en) * | 2014-12-22 | 2016-06-29 | Biosense Webster (Israel) Ltd. | Balloon for ablation around pulmonary veins |
| US10638976B2 (en) | 2016-04-28 | 2020-05-05 | Biosense Webster (Israel) Ltd | Method of constructing irrigated balloon catheter |
| US10653480B2 (en) | 2016-04-28 | 2020-05-19 | Biosense Webster (Israel) Ltd. | Method for constructing irrigated balloon catheter with flexible circuit electrode assembly |
| US10660700B2 (en) | 2016-04-28 | 2020-05-26 | Biosense Webster (Israel) Ltd. | Irrigated balloon catheter with flexible circuit electrode assembly |
| CN106861045A (en) * | 2017-03-30 | 2017-06-20 | 苏州景昱医疗器械有限公司 | Extension wire and the Implanted medical system including the extension wire |
| USD968422S1 (en) | 2019-05-31 | 2022-11-01 | Biosense Webster (Israel) Ltd. | Display screen with transitional graphical user interface |
| USD968421S1 (en) | 2019-05-31 | 2022-11-01 | Biosense Webster (Israel) Ltd. | Display screen with a graphical user interface |
| USD969138S1 (en) | 2019-05-31 | 2022-11-08 | Biosense Webster (Israel) Ltd. | Display screen with a graphical user interface |
| US11957852B2 (en) | 2021-01-14 | 2024-04-16 | Biosense Webster (Israel) Ltd. | Intravascular balloon with slidable central irrigation tube |
| US11963715B2 (en) | 2022-07-18 | 2024-04-23 | Biosense Webster (Israel) Ltd. | Balloon-in-balloon irrigation balloon catheter |
| CN117694997B (en) * | 2024-02-05 | 2024-04-26 | 成都飞云科技有限公司 | Ablation catheter, ablation handle and ablation assembly |
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