CN104095679A - Multiple-electrode ablation catheter - Google Patents
Multiple-electrode ablation catheter Download PDFInfo
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- CN104095679A CN104095679A CN201310127919.2A CN201310127919A CN104095679A CN 104095679 A CN104095679 A CN 104095679A CN 201310127919 A CN201310127919 A CN 201310127919A CN 104095679 A CN104095679 A CN 104095679A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
- A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
- A61B2018/00029—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids open
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1405—Electrodes having a specific shape
- A61B2018/1435—Spiral
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2218/00—Details of surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2218/001—Details of surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body having means for irrigation and/or aspiration of substances to and/or from the surgical site
- A61B2218/002—Irrigation
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Abstract
The invention relates to a multiple-electrode ablation catheter, which comprises a far side section, a main body section and a control handle, wherein the far side section, the main body section and the control handle are sequentially connected, and at least one part of the far side section can be reversibly changed into the peripheral configuration with lower contour, and is provided with a plurality of ablation electrodes. The ablation catheter is characterized in that the interiors of the main body section and the control handle are respectively provided with a filling liquid passage; the far side section comprises a filling liquid pipe cavity, and the side wall of the filling liquid pipe cavity is provided with an opening; each electrode is provided with at least one filling hole, at least one part of each electrode is fixedly arranged around the far side section, the filling liquid cavity is formed between each electrode and the filling liquid pipe cavity, and each filling hole is connected with a filling liquid source through a cavity, a corresponding opening, each filling liquid pipe cavity, and each filling liquid passage via fluid. The ablation catheter has the advantages that the spiral configuration of the far side section is adjusted according to requirements, multiple targets are ablated by multiple electrodes, and the ablation with an expected shape can be formed; a cooling liquid filling flow passage is formed by effectively utilizing the electrodes and the inner cavity of the guide pipe, and the heat is efficiently brought away at each part of each electrode.
Description
Technical field
The present invention relates to a kind of multi-electrode ablation catheter, melt for target site being carried out to multi-electrode electric discharge in body vessels, particularly a kind of multi-electrode ablation catheter that can be used for the treatment of renal artery denervation and pulmonary artery radio-frequency (RF) ablation.
Background technology
Intractable hypertension claims again refractory hypertension, refers to and adopts still out of contior hypertension of more than 3 kinds or 3 kinds antihypertensive drugs (comprising a kind of diuretic) treatment.Up-to-date animal and clinical experiment digital proof: the method that adopts percutaneous catheter to carry out radio-frequency (RF) ablation to kidney sympathetic nerve can reduce hypertension lastingly effectively.
The method has conduit and gets involved means, can utilize radio-frequency (RF) energy to carry out impedance type heating to the sympathetic nerve at renal artery position, can weaken its activity and even make its conduction function lose.The method not only can effectively be treated intractable hypertension, and there is Wicresoft, without advantages such as significant complications.Industry is considered as breakthrough this method, is considered to treat the new method of intractable hypertension.
Traditional electrode, in order to reach darker depth of ablation, can use higher ablation power clinically, easy in like this surperficial localized hyperthermia that forms of target spot, easily facilitates thrombosis, eschar, thereby affects safety and effectiveness, prolongation operating time, increase patient's misery.
In order to reach darker depth of ablation, can be in radio-frequency (RF) ablation, around radio-frequency electrode, spray equably infusion liquid, can make like this electrode reach higher power, can not increase fast its temperature, in ensureing therapeutic effect, can also prevent that target spot surface from forming localized hyperthermia simultaneously, reduce incrustation and thrombosed probability, improve safety and the effectiveness of operation.
Current distal section is spiral electrode ablation conduit, can send swimmingly and enters vascular to target site and form around the melting of the required form of vascular inwall in view of it, comes into one's own.It is spiral electrode ablation conduit that those skilled in the art have developed following multiple distal section.
Publication number is that the Chinese invention patent application of CN102198015A discloses a kind of retractable spiral laminar ring type electrode catheter, conduit and supporting sheath are collaborative to be used, the far-end of conduit is spiral stacked ring type, can fold narrowing of the ring and expansion by the flexible spiral of controlling of SMIS core bar, the SMIS core bar of the method need to have certain hardness, could control the folded narrowing of the ring of spiral and expansion.Between SMIS core bar and sheath, there is space, easily form herein thrombosis.Conduit in this application does not have infusion liquid perfusion functional, and cooling electrode and reduction electrode surface incrustation risk, can not ensure enough depth of ablation effectively.
Publication number is that the Chinese utility model patent application of CN201469401U discloses a kind of spiral renal-artery-around renal sympathetic nerve radio radio-frequency electrode conduit, and electrode is wherein continuous screw type, and this electrode is excessive, can not effectively ensure depth of ablation.Electrode distal end, without special protective measures, easily causes renal artery perforation in the time that conduit enters renal artery blood vessel, and risk is high.And without infusion liquid perfusion functional, incrustation risk is high.
Publication number is that the Chinese invention patent application of CN102488552A discloses one and can manipulate spiral electrode conduit, the Chinese invention patent application that is CN102198015A with publication number is similar, this conduit is also controlled the contraction of conduit by SMIS core bar, pour into without infusion liquid equally, can not effective cooling electrode.Between SMIS core bar and the main body of conduit, have space, between core bar and catheter main body, motion mutually, easily causes thrombosis.
Publication number is that the Chinese invention patent application of CN1549694A discloses a kind of electrophysiology device, it has spiral-shaped distal section, can in this distal section, arrange multiple electrodes, this distal section arranges its helical configuration by the core component wherein extending, and can reversibly be deformed into compared with low profile configuration, to send smoothly in vascular, but: it has only been mentioned and can use liquid coolant according to the feedback of temperature data, concrete infusion liquid filling mechanism is not disclosed, and the preferred spiral winding of electrode in distal section, obviously, electrode itself cannot become a part for liquid coolant perfusion stream, cannot be from electrode take away heat everywhere, in addition, this electrophysiologicalcatheter catheter can only make for making distal section be deformed into compared with low profile configuration and then send in vascular smoothly with guiding catheter is collaborative, but while use with guiding catheter is collaborative, it can increase total outer circumference diameter, in very thin vascular, can increase the discomfort of sending difficulty and increasing patient.
Publication number is that the Chinese invention patent application of CN101309651A discloses a kind of multi-electrode ablation catheter, the electric discharge that is applicable to arteries and veins nozzle position is melted, this conduit can control electrode and the degree that reclines of target position, but there is gap in the center core bar and the catheter main body that in part-structure, have, easily causes thrombosis; This conduit does not have the function of infusion liquid perfusion yet.
Therefore, a kind of multi-electrode ablation catheter need to be provided, its distal section can reversibly change at helical configuration and between compared with low profile configuration, so that successfully send in vascular, and utilize multiple target spots place of multiple electrode pair vascular inwalls of arranging in distal section to melt, form melting of intended shape; And this conduit also has infusion liquid filling mechanism, its inner chamber that can effectively utilize electrode and conduit forms liquid coolant perfusion stream, takes away efficiently heat everywhere thus from electrode; In addition, this conduit can depending on applicable cases neatly selection and guiding catheter, seal wire, guiding sheath is collaborative uses to send smoothly in vascular; This conduit can also utilize joystick to carry out the circle size of adjustable screw configuration via traction fiber in addition, while making in vascular need to be entered, can turn the diameter of helical configuration down, and in the time arriving near target spot, can tune up the diameter of helical configuration, make electrode each target spot that closely reclines.In addition, sometimes need the target spot melting to be strictly limited in longitudinal arrowband, this just needs the far-end of distal section to be connected with the multi-electrode ablation catheter of the adjustable annular ring of diameter, it also can successfully send in vascular, can utilize the approximate multiple target spots place dropping on a circle of multiple electrode pair vascular inwalls of arranging on annular ring to melt, forming intended shape is melting of annular.
Summary of the invention
The invention provides a kind of multi-electrode ablation catheter, comprise the distal section, main paragraph and the joystick that are linked in sequence, the at least part of of described distal section is circumferential configuration, this circumferential configuration can reversibly be changed into compared with low profile configuration, and on it, be furnished with multiple electrodes that melt use, it is characterized in that: in main paragraph and joystick, be provided with infusion liquid passage; Described distal section comprises infusion liquid tube chamber, on the sidewall of described infusion liquid tube chamber, has opening; And each electrode has at least one fill orifice, around the circumferential fixed and arranged of described distal section, and and forming cavity between infusion liquid tube chamber, each fill orifice is connected to the infusion liquid source of conduit outside via described cavity, corresponding opening, described infusion liquid tube chamber, described infusion liquid passage fluid.Utilize this multi-electrode ablation catheter, can regulate as required the helical configuration of distal section, for example, when multiple electrode catheter will enter in vascular, can be changed into compared with low profile configuration and be convenient to enter smoothly vascular and sending wherein; And in the time being delivered to target position, can recover the helical configuration of distal section to implement to melt with the target position reclining on sidewall, ensure depth of ablation and avoid the damage to perienchyma; And, can utilize multiple target spots place of multiple electrode pair vascular inwalls of arranging in distal section to melt, form melting of intended shape; And this conduit also has infusion liquid filling mechanism, its inner chamber that can effectively utilize electrode and conduit forms liquid coolant perfusion stream,, comprises inner and outer wall thus from electrode everywhere, takes away efficiently heat.
Described circumferential configuration can be taked various ways.Preferred two kinds of forms are: described distal section is helical configuration, or described distal section is loop configurations.
Preferably, described each electrode is evenly distributed on a week of described distal section part that presents circumferential configuration.Thus, can utilize each electrode that size is less to form the required shape that melts.
Preferably, the fill orifice on each electrode is with a row or multi-row layout, and the fill orifice in single is along being circumferentially evenly arranged, and adjacent row's fill orifice is and is staggered.Thus, infusion liquid can be filled into effectively to the regional of electrode surface via each fill orifice of distribution like this, thereby effectively realize the effect that cools of electrode.
Preferably, described distal section is multi-lumen tube, and the wherein fixing fixed wire of the first intracavity, in order to keep the circumferential configuration of distal section.The structure of this multi-lumen tube is convenient to utilize each chamber to hold respectively required member to avoid interfering with each other between member.For saving space meter, in the situation that guaranteeing that some members can not interfere with each other, for example wire and temperature sense line, also can together be contained in same intracavity by them.
Preferably, the nearside of described joystick is provided with connector conduit, and described in this, connector conduit is provided with the first female Luer, and described infusion liquid passage is connected to infusion liquid source via described connector conduit and the first female Luer.
Preferably, described fill orifice is prepared by a kind of mode in mechanical hole building, electric spark pore-forming, laser punching.Preferably, the diameter of described fill orifice is 0.02mm-0.5mm, and the quantity of fill orifice is 2-40.
The present invention also provides a kind of multi-electrode ablation catheter, comprise the distal section, main paragraph and the joystick that are linked in sequence, in described distal section, be furnished with multiple electrodes that melt use, it is characterized in that, described distal section is loop configurations, and described arrangement of electrodes is on the annular ring of described loop configurations.The design of this distal ports that is provided with annular ring, the strict limited situation of longitudinal extension of adaptation target spot, can dwindle the diameter of annular ring need to send in vascular time, and in the time that needs closely recline vascular inwall, can expand the diameter of annular ring.
Preferably, the described distal section of above-mentioned two kinds of multi-electrode ablation catheters is multi-lumen tube, and wherein an intracavity holds traction fiber, and described joystick is coupled to described traction fiber, and under the adjusting of joystick, the diameter of helical configuration or annular ring changes.Thus, can utilize as required joystick accurately and the diameter of adjustable screw configuration or annular ring easily, for example, when multiple electrode catheter will enter in vascular, can turn diameter down and be convenient to enter smoothly vascular and sending wherein; And when the diameter of helical configuration or annular ring is less than the internal diameter of vascular and causes not being adjacent to the sidewall of vascular when being delivered to target spot position, can tune up the target position of diameter closely to recline on sidewall, ensure depth of ablation and avoid the damage to perienchyma.
Preferably, the described distal section of above-mentioned two kinds of multi-electrode ablation catheters is multi-lumen tube, and wherein an intracavity holds seal wire, and passing into of seal wire stretched distal section, and withdrawing of seal wire makes distal section reply configuration, for example, reply helical configuration or reply loop configurations.Thus, this multi-electrode ablation catheter can be used in conjunction with the seal wire of applicable specification on the market, sends easily implementing.Preferably, the nearside of described joystick is provided with the second female Luer, and described seal wire passes into conduit via described the second female Luer, thus, can manipulate flexibly seal wire.
The present invention also provides a kind of multi-electrode ablation catheter, comprise the distal section, main paragraph and the joystick that are linked in sequence, described distal section is helical configuration, can reversibly change into compared with low profile configuration, and on it, be furnished with multiple electrodes that melt use, it is characterized in that: described distal section is multi-lumen tube, and wherein an intracavity holds seal wire, passing into of seal wire stretched distal section, and withdrawing of seal wire makes distal section reply helical configuration.Thus, the multi-electrode ablation catheter that this distal section is helical configuration can be used in conjunction with the seal wire of applicable specification on the market, sends easily implementing.
Brief description of the drawings
In order more clearly to describe technical scheme of the present invention, briefly introduce below in conjunction with accompanying drawing.Obviously, these accompanying drawings are only some detailed description of the invention that the application records.Include but not limited to following these accompanying drawings according to of the present invention.Hereinafter, taking away from operator near a side of target spot as distally, be nearside near operator's a side.
Represent more to approach linear configuration compared with low profile configuration, the helical configuration of for example minor diameter or the mutually larger-diameter helical configuration of regulable ring-shaped circle or regulable ring-shaped circle are respectively low profile configurations, and it is low profile configuration that the configuration of helical configuration under (comprise and the stretching) state of stretching compared original helical configuration.Circumferentially configuration expression is along the configuration of circumferential extension, and it has various ways, and for example distal section is helical configuration or loop configurations.Loop configurations represents the configuration that straight portion and annular ring are formed by connecting, and the quantity of annular ring and position can be determined as required.In the situation that distal section is helical configuration, present the spiral part that represents a pitch of this helical configuration for a week of the described distal section part of circumferential configuration, and in the situation that described distal section is loop configurations, present an annular ring of expression in a week of the described distal section part of circumferential configuration.
Annular electrode represents that this electrode is the revolving body along axial two open ends and hollow, and this revolving body can be straight tube, also can have the periphery of fluctuating, can also carry out chamfering in far and near both sides as required.In addition, term " fluid connection " represents to connect in mode that can transmitting fluid, the parts of for example two " fluid connection ", the transmission of can flowing between two parts of expression fluid.
Fig. 1 illustrates multi-electrode ablation catheter according to an embodiment of the invention, and it can pass into seal wire and also possess infusion liquid perfusion functional;
Fig. 2 illustrates the diagram that Fig. 1 sees along an a-a alignment left side;
Fig. 3 illustrates a kind of schematic diagram of the annular electrode with boss;
Fig. 4 illustrates fixed form between the annular electrode shown in Fig. 3 and the distal section of conduit and the schematic diagram of infusion liquid stream;
Fig. 5 A illustrates the schematic diagram that a kind of annular electrode of straight tube and the fill orifice on surface thereof distribute;
Fig. 5 B illustrates the schematic diagram that the annular electrode of another kind of straight tube and the fill orifice on surface thereof distribute;
Fig. 5 C illustrates the schematic diagram that the annular electrode of another straight tube and the fill orifice on surface thereof distribute;
Fig. 6 illustrates fixed form between the annular electrode of straight tube and the distal section of conduit and the schematic diagram of infusion liquid stream;
Fig. 7 illustrates that the multi-electrode ablation catheter shown in Fig. 1 passes into the schematic diagram of seal wire front and back;
Fig. 8 illustrates the profile of Fig. 7 along b-b line;
Fig. 9 illustrates the schematic diagram that can work in coordination with guiding catheter according to an embodiment of the invention the multi-electrode ablation catheter using;
Figure 10 illustrates the schematic diagram that can work in coordination with seal wire according to an embodiment of the invention the multi-electrode ablation catheter using;
Figure 11 illustrates the schematic diagram of the multi-electrode ablation catheter according to an embodiment of the invention with infusion liquid perfusion functional;
Figure 12 be illustrated on the basis of the multi-electrode ablation catheter shown in Figure 11, add the multi-electrode ablation catheter of the mechanism's gained regulating for the helical configuration of the distal section to multi-electrode ablation catheter and regulate before and after schematic diagram;
Figure 13 illustrates the diagram of seeing along a c-c alignment left side in Figure 12;
Figure 14 illustrates the profile along d-d line in Figure 12;
Figure 15 illustrates the multi-electrode ablation catheter of the helical configuration governor motion being provided with according to an embodiment of the invention shown in Figure 12 and regulates the schematic diagram of front and back, the collaborative use of this multi-electrode ablation catheter and guiding catheter;
Figure 16 illustrates the multi-electrode ablation catheter that is provided with the helical configuration governor motion shown in Figure 12 of one embodiment of the invention and regulates the schematic diagram of front and back, this multi-electrode ablation catheter can optionally be worked in coordination with and use with guiding catheter or seal wire, and has infusion liquid perfusion functional;
Figure 17 illustrates the multipole ablation catheter of annular ring configuration governor motion and the schematic diagram of adjusting front and back of one embodiment of the invention;
Figure 18 illustrates the diagram of seeing along an e-e alignment left side in Figure 17.
Detailed description of the invention
In order further to understand the present invention, below in conjunction with embodiment, preferred version of the present invention is described.These descriptions just illustrate the features and advantages of the present invention, but not limit the scope of the invention.
Fig. 1 show a kind of according to an embodiment of the invention can admittance silk and the multi-electrode ablation catheter with infusion liquid perfusion functional, it comprises at least part of distal section 1, main paragraph 4 and the joystick 6 for circumferential configuration that are linked in sequence, wherein, under the effect of power outside of the circumferential configuration of distal section 1, such as inserting the intracavity of guiding catheter or reversibly changing into compared with low profile configuration via passing into seal wire 22, for example stretched, to more successfully enter vascular and be delivered to target position.This circumferential configuration can be taked various ways, and for example, described distal section 1 can be helical configuration or loop configurations, utilizes the one or more annular rings in this helical configuration or loop configurations to form described circumferential configuration.As an example of loop configurations, the far-end of described distal section 1 is provided with (being for example connected with) annular ring, and this annular ring preferably diameter is adjustable.Following elder generation is taking distal section 1 as helical configuration as example describes, but those skilled in the art will know that, other forms of can to change under external force compared with the circumferential configuration along circumferential extension of low profile configuration be also available, and below what also can correspondingly be applicable to distal section 1 in distal section 1 for the various structures that are suitable in helical configuration situation is the situation of other forms of circumferential configuration at least partly.
In this distal section, be furnished with at least one electrode 2 for target spot is melted, each electrode 2 is at least in part around the circumferential fixed and arranged of described distal section.Each electrode 2 can, around the circumferential fixed and arranged of described distal section, can be taked various annulars thus, and for example, stage casing is as shown in Figure 3 provided with the annular electrode 209 of the annular electrode 201 of boss and the straight tube as shown in Fig. 5 A-5C etc.According to concrete applicable cases, each electrode 2 also can adopt the annular of part.Wherein, on electrode 2, can have at least one fill orifice 3, melt in vivo when for example carrying out renal artery denervation radio-frequency (RF) ablation, can carry out infusion liquid perfusion via filling mechanism, described filling mechanism is constructed as follows: in main paragraph and joystick, be provided with infusion liquid passage; Described distal section comprises that infusion liquid tube chamber 102(is as shown in Fig. 8 and Figure 14), on the sidewall of described infusion liquid tube chamber 102, there is opening; And between each electrode 2 and infusion liquid tube chamber 102, forming cavity (perfusion sap cavity 202 and 208 as shown in Figure 4 and Figure 6), each fill orifice 3 is connected to the infusion liquid source of conduit outside via described perfusion sap cavity 202, corresponding opening (opening 211 and 221 as shown in Figure 4 and Figure 6), described infusion liquid tube chamber 102, described infusion liquid passage fluid.By utilizing this filling mechanism, infusion liquid can be transported to perfusion sap cavity 202 from infusion liquid source via described infusion liquid passage, infusion liquid tube chamber 102 and opening, and accumulate therein, during accumulating, absorb the heat of electrode 2 from inwall, while being full of, spray infusion liquid from fill orifice 3, the outer wall of electrode is washed away with cooling, thereby can more effectively carry out cooling and take away efficiently heat everywhere from it electrode 2, more powerful energy can be on electrode 2, inputted thus, thereby the degree of depth of electrode ablation can be ensured.
The distal section 1 of described helical configuration can be multi-lumen tube, infusion liquid tube chamber 102 is a chamber wherein, in other each chambeies, can hold respectively required parts, for example, in traction fiber, seal wire, wire, fixed wire and temperature sense line one or more, also can, in the situation that not affecting operation separately, for example wire of multiple parts and temperature sense line be contained in to identical intracavity.This multi-lumen tube can be prepared by the material such as block copolymer, nylon of polyurethane, polyethers and polyamide, and the quantity in the chamber of multi-lumen tube is 1-6, and preferably the quantity in chamber is 2-5.The present invention is taking four lumens as the applicable cases of example introduction in multi-electrode ablation catheter, and the diameter of multi-lumen tube is 0.9-3.0mm, and this four chamber is guidewire lumen 103, fixed wire tube chamber 104, infusion liquid tube chamber 102 and guidewire lumen 105.In described fixed wire tube chamber 104, be fixed with fixed wire 12 in order to keep the shape of helical configuration, this fixed wire 12 can be prepared by materials such as the block copolymer silks containing titanium-nickel wire, stainless steel silk, polyurethane filament, polyethers silk, polyamide.Guidewire lumen 103 in the distal section 1 of this helical configuration is interior can pass into seal wire 22, and multi-electrode ablation catheter can use with seal wire 22 is collaborative according to an embodiment of the invention, so that multi-electrode ablation catheter is delivered to the target position in body vessels.For example, first seal wire 22 is entered in renal artery blood vessel via femoral artery routine, then this multi-electrode ablation catheter is delivered to the target position of renal artery blood vessel along seal wire 22.Multi-electrode ablation catheter passes into the schematic diagram of seal wire 22 front and back and sees Fig. 7.
The electrode 2 of arranging in the distal section of this helical configuration can be 1-15, and preferred electrode number is 4-10.Electrode 2 can be prepared by materials such as platinumiridio, gold, silver, platinum, copper, rustless steels, fill orifice 3 on electrode 2, shown in fill orifice D as shown in Figure 4 and Figure 6, can optionally prepare by a kind of mode in mechanical hole building, electric spark pore-forming, laser punching.On each electrode 2, be connected with wire 13, near electrode 2, be provided with the heat sensor of the temperature of electrode while melting for perception electric discharge, this heat sensor is connected to the temperature sense line 14 in guidewire lumen 105, wire 13 and temperature sense line 14 are connected on the buttock line socket 7 of joystick 6 near-ends after the distal section 1 of helical configuration and main paragraph 4, be respectively used to transmit the signal of telecommunication and/or pulsed radio-frequency power and temperature feedback signal, thereby can greatly improve the safety in utilization of this ablation catheter.
The main paragraph 4 of multi-electrode ablation catheter is that the tubing that braided wires and Polymer materialspreparation form forms, one or more in the block copolymer silk that this braided wires comprises titanium-nickel wire, stainless steel silk, polyurethane filament, polyethers silk, polyamide, and establishment silk can be monolayer braided wires or multilamellar establishment silk; This macromolecular material is selected from the material such as block copolymer, nylon of polyurethane, polyethers and polyamide.Joystick 6 grips for patient, can be by polypropylene (PP), the material preparations such as polyethylene (PE), silica gel, rubber, polyformaldehyde (POM), polrvinyl chloride (PVC), copolyester (PETG), polystyrene (HIPS), acrylonitrile-butadiene-styrene (ABS) plastics (ABS), be connected with main paragraph 1, for conduit is carried out to various control.Joystick 6 near-ends can have buttock line socket 7, and this buttock line socket 7 is for connecting radiofrequency generator by supporting buttock line.Joystick 6 near-ends can be provided with connector conduit 9, and this connector conduit 9 connects respectively female Luer 8 and female Luer 10.Described female Luer 8 is connected to infusion liquid 11 for fluid, infusion liquid 11 enters in multi-electrode ablation catheter from female Luer 8, pass through successively connector conduit 9, the interior infusion liquid passage of joystick 6 (not indicating in figure) enters main paragraph 4, then, shown in Figure 4, enter the infusion liquid tube chamber 102 in the distal section 1 of helical configuration, then infusion liquid 11 enters infusion liquid chamber 202 after multi-lumen tube sidewall opening 211, finally eject from fill orifice 203, stage casing has in the perfusion sap cavity 202 in the annular electrode 201 of boss and is full of infusion liquid 11, and constantly eject, take away a large amount of heats, can effectively take away the energy of electrode, reduce the temperature of electrode, also reduced the risk of electrode surface incrustation.Infusion liquid can be selected the liquid coolant to human-body safety, such as cool brine etc.
As shown in Figure 2, from Fig. 1, look left vertically, it is upper that the helical configuration of distal section 1 is stacked in circle, and this diameter of a circle is 3-30mm.All electrodes 2 are evenly distributed on a week of helical configuration.In the time that the quantity of electrode 2 is 4, in Fig. 2, electrode 2 is evenly distributed on round periphery, and adjacent both angles are 90 °.Preferably, fill orifice 3 is along being circumferentially evenly distributed on the surface of each electrode 2.In the time that the quantity of electrode 2 exceedes 4, electrode 2 is also evenly distributed on round periphery, and in Fig. 2, the angle between electrode 2 can be multiple, obtain its number of degrees by the quantity of 360 °/electrode 2, wherein typical angle comprises 72 °, 60 °, 45 ° and 40 ° etc.Above-described angle is typical angle, but situation of the present invention is not limit above-described several situation, is still applicable to similarly other angles.
Fig. 3 illustrates a kind of schematic diagram of the annular electrode 201 with boss.The described annular electrode 201 with boss comprises bottom 204, boss portion 207 and the excessive portion 205 that is connected both, and be distributed in the fill orifice 203 in boss portion 207, this fill orifice 203 can connect the sidewall of boss portion 207, between the sidewall of boss portion 207 and infusion liquid tube chamber 102, form perfusion sap cavity 202 as shown in Figure 4, each fill orifice 203 is via described perfusion sap cavity 202 thus, corresponding opening (opening 211 as shown in Figure 4), described infusion liquid tube chamber 102, described infusion liquid passage fluid is connected to the infusion liquid source of conduit outside, pour into utilize the infusion liquid of carrying.The quantity of the fill orifice 203 on the described annular electrode 201 with boss is at least 1, fill orifice 203 quantity on the annular electrode with boss 201 described in Fig. 3 are 6, being divided into two rows distributes, each row is uniformly distributed circumferentially 3 fill orifices 203, this two irrigation and drainage orifice 203 is and is staggered, as shown in Figure 3.Infusion liquid can be filled into effectively to the regional of electrode surface via each fill orifice, thereby effectively realize the effect that cools of electrode.Fill orifice 203 quantity of the annular electrode with boss 201 shown in Fig. 3 and row are only example, and the quantity of described fill orifice 203 can be the arbitrary quantity in 2-40, and row can be the arbitrary quantity in 2-6 row.The diameter of described fill orifice 203 is 0.02-0.5mm, and preferably, the diameter of described fill orifice is 0.08-0.2mm.
Fig. 5 A illustrates the schematic diagram that a kind of annular electrode of straight tube and the fill orifice on surface thereof distribute.On described annular electrode 209, have two irrigation and drainage orifices 210, each row is uniformly distributed circumferentially 3 fill orifices 210, and this two irrigation and drainage orifice 210 is and is staggered.Fig. 5 B illustrates the schematic diagram that the annular electrode of another kind of straight tube and the fill orifice on surface thereof distribute.On described annular electrode 214, have two irrigation and drainage orifices 210, each row is uniformly distributed circumferentially 4 fill orifices 210, and this two irrigation and drainage orifice 210 is and is staggered.Fig. 5 C illustrates the schematic diagram that the annular electrode of another straight tube and the fill orifice on surface thereof distribute.On described annular electrode 213, have three irrigation and drainage orifices 210, each row is uniformly distributed circumferentially 3 fill orifices 210, and 210 of the fill orifices of any two the adjacent rows in this three irrigation and drainage orifice 210 are and are staggered.As shown in Figure 5 C, between adjacent row's fill orifice 210, along 60 degree that circumferentially stagger, first row and the 3rd row's fill orifice 210 is upwards alignd in week.
Fill orifice on annular electrode shown in Fig. 5 A-5C is arranged as example of the present invention, also can take as required the arrangement of the fill orifice of other quantity in 2-40.Preferably, fill orifice on each electrode is with a row or multi-row layout, fill orifice in single is along being circumferentially evenly arranged, and adjacent row's fill orifice is and is staggered, can in multiple lengthwise positions, spray equably infusion liquid from the circumferential multiple angle positions of electrode like this, to take away equably heat everywhere from electrode.On annular electrode along with the increase of fill orifice quantity, the corresponding fill orifice diameter that reduces.Otherwise, on annular electrode along with the increase of fill orifice diameter, corresponding minimizing fill orifice quantity.Preferably, on annular electrode, the quantity of fill orifice is 4-20, is divided into a row or multi-row arrangement.Can prepare the fill orifice on annular electrode by modes such as mechanical hole building, electric spark pore-forming, laser punchings, the diameter of described fill orifice is 0.02mm-0.5mm, and preferably, the diameter of described fill orifice is 0.08-0.2mm.
Fig. 4 illustrates fixed form between the annular electrode shown in Fig. 3 and the distal section of conduit and the schematic diagram of infusion liquid stream.The annular electrode 201 with boss is secured together with multi-lumen tube 101, the bottom 204 with the annular electrode of boss contacts with multi-lumen tube 101, both contacts site are realized both by thermal weld, glue or mechanical system and are sealed fixing, boss portion 207, between specifically its inwall, and multi-lumen tube 101, form perfusion sap cavity 202.Wherein on the sidewall of the infusion liquid tube chamber 102 in multi-lumen tube 101, there is opening 211, infusion liquid 11 is from female Luer 8(as shown in Figure 1) enter multi-electrode ablation catheter, the distal section 1(multi-lumen tube 101 that enters helical configuration through the infusion liquid passage in multi-electrode ablation catheter (not indicating in Fig. 1)) in infusion liquid tube chamber 102, infusion liquid 11 enters multi-lumen tube 101 along the flow direction of arrow " A " instruction, after the opening 211 on the sidewall of infusion liquid tube chamber 102, infusion liquid 11 is divided into both direction, a part continues distad to flow along infusion liquid tube chamber 102, as shown in arrow " C ", another part enters chamber 202 along the flow direction of arrow " B " instruction via sidewall opening 211.Infusion liquid 11 fills perfusion sap cavity 202, flows out, from 6 fill orifices 203 that have the annular electrode 201 of boss as shown in the arrow in Fig. 4 " D ".Infusion liquid 11 constantly enters perfusion sap cavity 202, and flow out or spray from fill orifice 203 after sap cavity 202 being full of perfusion, in the process that infusion liquid 11 is accumulated in perfusion sap cavity 202, the inwall from annular electrode 201 absorbs heat constantly, and can wash away cooling to the outer wall of annular electrode 201 from fill orifice 203 flows out or sprays, thus can be from thering is the inside and outside heat that absorbs fully of annular electrode 201 of boss, can effectively reduce the temperature of the annular electrode 201 with boss, can increase electric discharge ablation power, improve depth of ablation, and reduce electrode surface incrustation risk.
Fig. 6 illustrates fixed form between the annular electrode of straight tube and the distal section of conduit and the schematic diagram of infusion liquid stream.The annular electrode 209 of this straight tube is substantially straight tube shape except the edge (shown in oblique line) of both sides, together with being affixed to multi-lumen tube 101.By glue or hot linked mode, the both sides of the edge of annular electrode 209 and multi-lumen tube 101 are sealed fixing, make the outer wall of the infusion liquid tube chamber 102(in middle part (inwall) and the multi-lumen tube 101 of annular electrode 209) between form perfusion sap cavity 208.With situation shown in Fig. 4 similarly, infusion liquid 11 enters after infusion liquid tube chamber 102, flow along arrow " A " indicated direction, opening 212 on infusion liquid tube chamber 102 sidewalls is punished into both direction: a part continues distad to flow along infusion liquid tube chamber 102, as shown in the arrow in Fig. 6 " C ", another part flows into perfusion sap cavity 208 via sidewall opening 212 along arrow " B " indicated direction, infusion liquid fills after perfusion sap cavity 208, fill orifice 206 from annular electrode 209 flows out, as shown in the arrow in Fig. 6 " D ".Infusion liquid 11 in perfusion sap cavity in 208 processes of accumulating constantly the inwall from annular electrode 209 absorb heat, and can wash away cooling to the outer wall of annular electrode 209 from fill orifice 206 flows out or sprays, thus can be from thering is the inside and outside heat that absorbs fully of annular electrode 209 of straight tube, can effectively reduce the temperature of the annular electrode 209 with straight tube, can increase electric discharge ablation power, improve depth of ablation, and reduce electrode surface incrustation risk.
Fig. 7 illustrates that the multi-electrode ablation catheter shown in Fig. 1 passes into the schematic diagram of seal wire front and back.Described multi-electrode ablation catheter has infusion liquid perfusion functional, can be used in conjunction with the guiding catheter that is applicable on the market specification, also can be used in conjunction with the seal wire that is applicable on the market specification, multi-electrode ablation catheter is transported to the target spot position of vascular in human body.Multi-electrode ablation catheter passes into after seal wire 22, and the main body of seal wire 22 provides support power, the distal section of the helical configuration of multi-electrode ablation catheter 1 is supportted directly, as shown in the dashed line view in Fig. 7.Seal wire 22 enters multi-electrode ablation catheter from female Luer 10, then enters the silk guide passage (not indicating in figure) in multi-electrode ablation catheter, and the far-end of silk guide passage is provided with opening can be for the far-end pass-out of seal wire.The surface of seal wire 22 has superslide coating, make seal wire 22 can the silk guide passage in multi-electrode ablation catheter in smooth and easy passing through.Like this, multi-electrode ablation catheter can be by seal wire 22 by multi-electrode ablation catheter successfully by the target position of femoral artery vascular in retrograde blood enters human body, these target positions include but not limited to renal artery blood vessel, pulmonary artery etc.In the time that seal wire 22 enters vascular, seal wire 22 far-ends are provided with the extraordinary seal wire stretch section 21 of compliance, can enter in body vessels very smoothly, and can not damage vascular tissue.The near-end 23 of seal wire can be fixed, so that seal wire 22 positions after entering body vessels.Behind the location, target spot place of distal section 1 vascular in human body of helical configuration, clamping seal wire near-end 23 withdraws seal wire 22, the distal section 1 of helical configuration is reverted back to spiral-shaped, so that electrode 2 abuts in the target position in vascular effectively.
Fig. 8 illustrates the profile of Fig. 7 along b-b line.As shown in Figure 8, multi-lumen tube 101 comprises four chambeies, is respectively infusion liquid tube chamber 102, guidewire lumen 103, fixed wire tube chamber 104 and guidewire lumen 105.Wherein, described infusion liquid tube chamber 102 is as a part for infusion liquid stream, for transmitting infusion liquid; Guidewire lumen 103, for passing into seal wire, arrives the target position of body vessels to guide multi-electrode ablation catheter; In fixed wire tube chamber 104, be fixed with fixed wire, for keeping the helical configuration of distal section 1, the material of fixed wire can be selected from but be not limited to the materials such as the block copolymer silk of titanium-nickel wire, stainless steel silk, polyurethane filament, polyethers silk, polyamide; In guidewire lumen 105, hold wire 13 and temperature sense line 14, wire 13 and temperature sense line 14 are affixed on the pin of buttock line socket 7 correspondences successively after main paragraph 4 and joystick 6, to transmit the signal of telecommunication and carry radio-frequency pulse energy.
Fig. 9 illustrates schematic diagram, the distal section 1 that it comprises helical configuration and multiple electrodes 2, main paragraph 4, handle function part 5, joystick 6 and the buttock line socket 7 around its layout that can work in coordination with guiding catheter according to an embodiment of the invention the multi-electrode ablation catheter using.Described multi-electrode ablation catheter can be used in conjunction with guiding catheter, guiding catheter first arrives the target position place in vascular, described multi-electrode ablation catheter arrives after target position by guiding catheter, fixing multi-electrode ablation catheter, withdraw guiding catheter, the distal section 1 of multi-electrode ablation catheter 1 is replied after helical configuration, and the electrode 2 in the distal section 1 of helical configuration clings to the target position on vascular.Then can carry out signal extraction to target position, and transport pulse radio-frequency (RF) energy, realize electric discharge ablation functionality.
Figure 10 illustrates schematic diagram, the distal section 1 that it comprises helical configuration and multiple electrodes 2, main paragraph 4, handle function part 5, joystick 6, buttock line socket 7 and the female Luer 10 around its layout that can work in coordination with seal wire according to an embodiment of the invention the multi-electrode ablation catheter using.Described multi-electrode ablation catheter contains silk guide passage (not indicating in figure), passes into after seal wire 22 in multi-electrode ablation catheter, and seal wire 22 can support the distal section of helical configuration 1 directly.Seal wire 22 arrives the target position in vascular, and then multi-electrode ablation catheter arrives after target position along seal wire 22, withdraws seal wire 22, and distal section 1 reverts back to helical configuration, makes electrode paste lean on target position.Then can carry out signal extraction to target position, and transport pulse radio-frequency (RF) energy, realize electric discharge ablation functionality.
Figure 11 illustrates the schematic diagram of the multi-electrode ablation catheter according to an embodiment of the invention with perfusion of saline function, fill orifice 3, main paragraph 4, handle function part 5, joystick 6, buttock line socket 7, female Luer 8 and connector conduit 9 on the distal section 1 that it comprises helical configuration, multiple electrodes 2 of arranging around distal section 1, each electrode 2.In described main paragraph 4 and joystick 6, be provided with infusion liquid passage (not indicating in figure), from the infusion liquid in infusion liquid source after female Luer 8, enter the distal section 1 of helical configuration by infusion liquid passage, then enter the interior (see figure 4) of perfusion sap cavity 202 of inwall and the infusion liquid tube chamber 102 of electrode 2, flow out electrode 2 finally by crossing fill orifice 203, infusion liquid 11 can be from the inside and outside heat of taking away efficiently electrode 2, thereby can increase the power on electrode 2, increase the depth of ablation of target position.
Figure 12 be illustrated on the basis of the multi-electrode ablation catheter shown in Figure 11, add the multi-electrode ablation catheter of the mechanism's gained regulating for the helical configuration of the distal section to multi-electrode ablation catheter and regulate before and after schematic diagram.Distal section 1, electrode 2, fill orifice 3, main paragraph 4, handle function part 5, joystick 6, buttock line socket 7, female Luer 8 and connector conduit 9 that this multi-electrode ablation catheter comprises helical configuration.Wherein said handle function part 5 is for controlling the diameter of helical configuration of distal section 1, be convenient to the size of multi-electrode ablation catheter adjustable screw circle, so that multi-electrode ablation catheter can conveniently enter vascular in human body, and electrode can be clinged in blood vessel wall effectively.As shown in figure 13, in Figure 12, see along a c-c alignment left side, the distal section 1 of helical configuration is projected on same circumference 16 in the axial direction, and the projection of electrode 2 is distributed on circumference 16 equably, and fill orifice 3 is arranged on electrode 2 according to certain rules.Traction fiber 15 is contained in the traction fiber chamber 103 of multi-lumen tube 101 (as shown in figure 14), and is coupled to the handle function part 5 on joystick 6, and traction fiber 15 is controlled the diameter of the helical configuration of distal section 1 by handle function part 5.
Utilize handle function part 5 to regulate after the diameter of helical configuration of distal section 1, the distal section 1 of helical configuration is also projected in a circumference 17(in the axial direction referring to shown in dotted line) on.Can utilize as required handle function part 5 that the diameter of the helical configuration of distal section 1 is turned down or tuned up.The diameter of helical configuration is convenient to multi-electrode ablation catheter and is entered body vessels after turning down, the distal section 1 of being convenient to helical configuration after tuning up clings in vascular in blood vessel wall in human body, and the electrode 2 in multi-lumen tube 101 can cling to the target spot in blood vessel wall effectively.Discharge while melting, multi-electrode ablation catheter shown in Figure 12 can pour into infusion liquid from infusion liquid source from female Luer 8 and connector conduit 9, the infusion liquid finally fill orifice 3 from electrode 2 flows out, effectively reduce the temperature of electrode 2 and target spot tissue, can improve ablation power, increase the depth of ablation to tissue.
Figure 15 and Figure 16 show respectively the schematic diagram according to the multi-electrode ablation catheter that is provided with the helical configuration governor motion shown in Figure 12 of two embodiment of the present invention and before and after regulating, wherein, multi-electrode ablation catheter shown in Figure 15 can use with guiding catheter is collaborative, and the multi-electrode ablation catheter shown in Figure 16 not only can use with guiding catheter is collaborative, can also use with seal wire is collaborative, and there is infusion liquid perfusion functional.
Above only taking Fig. 9 as exemplified a kind of can with the collaborative multi-electrode ablation catheter using of guiding catheter, but need to know, above those can with the collaborative multi-electrode ablation catheter using of seal wire, can use with the guiding catheter of appropriate size is collaborative.Operator can be according to the suitability and the cost etc. of the seal wire of operation demand and appropriate size and guiding catheter, selects one to assist multi-electrode ablation catheter to send location.
Be the various structures that are suitable in helical configuration situation in distal section 1 above, what the structure structure relevant with traction fiber that especially seal wire is relevant also can be applicable to respectively or in combination distal section 1 is the situation of other forms of circumferential configuration at least partly, the situation that for example distal section 1 is loop configurations, in the case, the multiple electrode 2 that melts use is arranged on the annular ring of described loop configurations.A kind of loop configurations that is connected with a regulable ring-shaped circle taking the far-end of distal section 1 below describes as example.
Figure 17 shows the far-end of distal section 1 according to an embodiment of the invention and is connected with a regulable ring-shaped circle and multiple electrode 2 that melts use and is distributed in the schematic diagram of the multi-electrode ablation catheter in annular ring, wherein the schematic diagram of annular ring shown in broken lines after turning down.In the present embodiment, the junction of the far-end of annular ring and conduit can be arranged on the edge of annular ring, and in addition, the junction of the far-end of annular ring and conduit also can be arranged on the center of annular ring, and this connected mode also within the scope of the invention.Shape after the annular ring of illustrated embodiment is turned down is shown in Figure 17 and 18 shown in dotted line.Number of electrodes in this embodiment is 10, is more applicable to melting of the body lumen larger with vascular diameter.The annular ring of this embodiment can regulate its loop size, can coordinate guiding catheter to enter in body vessels, particularly the part such as orifices of pulmonary veins, pulmonary orifice, renal artery ostium and pulmonary vein, pulmonary artery, renal artery blood vessel melts, not only improve and melt efficiency, this sizable design of annular ring can cling to ablating electrode target spot position more effectively, ensures ablation effect.In addition, far-end is connected with the design of multi-electrode ablation catheter of adjustable annular ring except the scheme that this embodiment provides, can also with scheme shown in various embodiment in seal wire haulage gear and filling mechanism in any one or two kinds ofly use in combination.With regard to seal wire haulage gear, described distal section is multi-lumen tube, and wherein an intracavity holds seal wire, and passing into of seal wire makes distal section comprise that annular ring stretches, the withdrawing of seal wire make distal section reply configuration namely far-end be connected with the original configuration of annular ring.The diameter adjustment mechanism of this annular ring is to above the relevant regulatory mechanism for helical configuration is similar with Figure 12-14, also be following realization: traction fiber 15 is contained in the traction fiber chamber 103 of multi-lumen tube 101 (as shown in figure 14), and being coupled to the handle function part 5 on joystick 6, traction fiber 15 is controlled the diameter of the regulable ring-shaped circle of distal section 1 by handle function part 5.
The present invention is not limited to the particular content described in detailed description of the invention.The conduit of a kind of interior therapeutic provided by the present invention melts in ablation arrhythmia and renal artery sympathetic nerve treatment hypertension purposes in heart, the electric discharge ablative surgery of body vessels such as is also suitable in other intracardiac and/or blood vessels.
The explanation of above embodiment is just for helping to understand core concept of the present invention.It should be pointed out that for the ordinary skill in the art, under the premise without departing from the principles of the invention, can also carry out some improvement and modification to the present invention, but these improvement and modification also fall in the scope of the claims in the present invention request protection.
Claims (16)
1. a multi-electrode ablation catheter, comprise the distal section, main paragraph and the joystick that are linked in sequence, at least part of of described distal section is circumferential configuration, and this circumferential configuration can reversibly be changed into compared with low profile configuration, and on it, be furnished with multiple electrodes that melt use, it is characterized in that:
In main paragraph and joystick, be provided with infusion liquid passage;
Described distal section comprises infusion liquid tube chamber, on the sidewall of described infusion liquid tube chamber, has opening; And
Each electrode has at least one fill orifice, each electrode is at least in part around the circumferential fixed and arranged of described distal section, and and forming cavity between infusion liquid tube chamber, each fill orifice is connected to the infusion liquid source of conduit outside via described cavity, corresponding opening, described infusion liquid tube chamber, described infusion liquid passage fluid.
2. multi-electrode ablation catheter according to claim 1, is characterized in that, described distal section is helical configuration, or described distal section is loop configurations.
3. multi-electrode ablation catheter according to claim 1, is characterized in that, described each electrode is evenly distributed on a week of described distal section part that presents circumferential configuration.
4. multi-electrode ablation catheter according to claim 1, is characterized in that, the fill orifice on each electrode is with a row or multi-row layout, and the fill orifice in single is along being circumferentially evenly arranged, and adjacent row's fill orifice is and is staggered.
5. multi-electrode ablation catheter according to claim 1, is characterized in that, described distal section is multi-lumen tube, and the wherein fixing fixed wire of the first intracavity, in order to keep the circumferential configuration of distal section.
6. multi-electrode ablation catheter according to claim 1, it is characterized in that, the nearside of described joystick is provided with connector conduit, and described in this, connector conduit is provided with the first female Luer, and described infusion liquid passage is connected to infusion liquid source via described connector conduit and the first female Luer.
7. multi-electrode ablation catheter according to claim 1, is characterized in that, described fill orifice is prepared by a kind of mode in mechanical hole building, electric spark pore-forming, laser punching.
8. multi-electrode ablation catheter according to claim 1, is characterized in that, the diameter of described fill orifice is 0.02mm-0.5mm, and the quantity of fill orifice is 2-40.
9. a multi-electrode ablation catheter, comprise the distal section, main paragraph and the joystick that are linked in sequence, in described distal section, be furnished with multiple electrodes that melt use, it is characterized in that, described distal section is loop configurations, and described arrangement of electrodes is on the annular ring of described loop configurations.
10. according to the multi-electrode ablation catheter described in claim 1 or 9, it is characterized in that, described distal section is multi-lumen tube, wherein an intracavity holds traction fiber, described joystick is coupled to described traction fiber, and under the adjusting of joystick, the diameter of helical configuration or annular ring changes.
11. according to the multi-electrode ablation catheter described in claim 1 or 9, it is characterized in that, described distal section is multi-lumen tube, and wherein an intracavity holds seal wire, and passing into of seal wire stretched distal section, and withdrawing of seal wire makes distal section reply configuration.
12. multi-electrode ablation catheters according to claim 10, is characterized in that, described distal section is multi-lumen tube, and wherein an intracavity holds seal wire, and passing into of seal wire stretched distal section, and withdrawing of seal wire makes distal section reply configuration.
13. 1 kinds of multi-electrode ablation catheters, comprise the distal section, main paragraph and the joystick that are linked in sequence, described distal section is helical configuration, can reversibly change into compared with low profile configuration, and on it, be furnished with multiple electrodes that melt use, it is characterized in that: described distal section is multi-lumen tube, and wherein an intracavity holds seal wire, passing into of seal wire stretched distal section, and withdrawing of seal wire makes distal section reply helical configuration.
14. multi-electrode ablation catheters according to claim 13, is characterized in that, the nearside of described joystick is provided with the second female Luer, and described seal wire passes into conduit via described the second female Luer.
15. 1 kinds of multi-electrode ablation catheters, comprise the distal section, main paragraph and the joystick that are linked in sequence, described distal section is helical configuration, can reversibly change into compared with low profile configuration, and on it, be furnished with multiple electrodes that melt use, it is characterized in that: described distal section is multi-lumen tube, wherein an intracavity holds traction fiber, described joystick is coupled to described traction fiber, and under the adjusting of joystick, the diameter of helical configuration changes.
16. multi-electrode ablation catheters according to claim 15, is characterized in that, described each electrode is evenly distributed on a week of described helical configuration.
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| CN201310127919.2A CN104095679A (en) | 2013-04-12 | 2013-04-12 | Multiple-electrode ablation catheter |
| PCT/CN2014/075318 WO2014166436A1 (en) | 2013-04-12 | 2014-04-14 | Multi-electrode ablation catheter |
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| CN201310127919.2A CN104095679A (en) | 2013-04-12 | 2013-04-12 | Multiple-electrode ablation catheter |
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| US11259868B2 (en) | 2015-05-13 | 2022-03-01 | Shanghai Golden Leaf Med Tec Co., Ltd. | Corrugated radiofrequency ablation catheter and apparatus thereof |
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| CN105125281A (en) * | 2015-05-13 | 2015-12-09 | 上海魅丽纬叶医疗科技有限公司 | Corrugated radiofrequency ablation catheter and radiofrequency ablation device |
| CN105125281B (en) * | 2015-05-13 | 2017-09-22 | 上海魅丽纬叶医疗科技有限公司 | A kind of ripple type radio frequency ablation catheter and its equipment |
| US11259868B2 (en) | 2015-05-13 | 2022-03-01 | Shanghai Golden Leaf Med Tec Co., Ltd. | Corrugated radiofrequency ablation catheter and apparatus thereof |
| CN109350221A (en) * | 2018-09-14 | 2019-02-19 | 白龙腾 | Reducing screw multipole ablation catheter |
| CN113384319A (en) * | 2021-06-02 | 2021-09-14 | 上海腾复医疗科技有限公司 | A catheter |
| CN113384319B (en) * | 2021-06-02 | 2023-04-25 | 上海腾复医疗科技有限公司 | Catheter |
| CN114343833A (en) * | 2021-11-29 | 2022-04-15 | 苏州艾科脉医疗技术有限公司 | Ablation catheter |
| CN115998408A (en) * | 2023-03-24 | 2023-04-25 | 中日友好医院(中日友好临床医学研究所) | Cryoablation probe and surgical equipment for bronchovagal nerve blocking |
| CN117694997A (en) * | 2024-02-05 | 2024-03-15 | 成都飞云科技有限公司 | Ablation catheter, ablation handle and ablation assembly |
| CN117694997B (en) * | 2024-02-05 | 2024-04-26 | 成都飞云科技有限公司 | Ablation catheter, ablation handle and ablation assembly |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014166436A1 (en) | 2014-10-16 |
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