CN114343833A

CN114343833A - Ablation catheter

Info

Publication number: CN114343833A
Application number: CN202111434063.4A
Authority: CN
Inventors: 阴杰; 张雷
Original assignee: Suzhou Aikemai Medical Technology Co ltd
Current assignee: Suzhou Aikemai Medical Technology Co ltd
Priority date: 2021-11-29
Filing date: 2021-11-29
Publication date: 2022-04-15

Abstract

The invention discloses an ablation catheter, comprising: the ablation catheter comprises a catheter body, wherein the catheter body is provided with a first electrode and a second electrode, and the ablation catheter is switched between a radio frequency ablation mode and a pulse ablation mode by controlling the working states of the first electrode and the second electrode; the perfusion pipeline is used for conveying cooling liquid to the lesion part; and the temperature adjusting device is used for heating and/or cooling the cooling liquid in the filling pipeline so as to adjust the temperature of the cooling liquid in the filling pipeline. From this, through the ablation catheter of this application, the ablation catheter can freely switch into radio frequency ablation mode or pulse ablation mode, can make the art person freely switch over at the operation in-process to can shorten greatly and melt the time, also can reduce the complication and promote and melt the effect, and, can adjust the cooling fluid temperature in the filling pipe to suitable temperature, can guarantee cooling fluid cooling effect, also can avoid the cooling fluid to cause the damage to near region of pathological change position.

Description

Ablation catheter

Technical Field

The invention relates to the field of medical catheters, in particular to an ablation catheter.

Background

In the related art, the existing ablation catheter only has one ablation mode, namely, the ablation catheter has a radio frequency ablation mode or a pulse ablation mode, the ablation catheter does not have the radio frequency ablation mode and the pulse ablation mode at the same time, and the ablation catheter does not have a function of adjusting the temperature of cooling liquid in a perfusion pipeline, the temperature of the cooling liquid in the perfusion pipeline cannot be kept at a proper working temperature, when the temperature of the cooling liquid in the perfusion pipeline is high, the cooling effect of the cooling liquid is poor, and when the temperature of the cooling liquid in the perfusion pipeline is low, the cooling liquid flows to a region near a lesion part, and then the region near the lesion part is easily damaged.

Disclosure of Invention

The present invention is directed to solving at least one of the problems of the prior art. To this end, it is an object of the present invention to provide an ablation catheter that can be freely switched to a radio frequency ablation mode or a pulse ablation mode, and also can adjust the temperature of the coolant in the irrigation line to a suitable temperature.

An ablation catheter according to the invention, the ablation catheter having a radio frequency ablation mode and a pulse ablation mode, comprising: the catheter body is provided with a first electrode and a second electrode, and the ablation catheter is switched between the radio frequency ablation mode and the pulse ablation mode by controlling the working states of the first electrode and the second electrode; the perfusion pipeline is at least partially arranged in the catheter body and used for conveying cooling liquid to a lesion part; a temperature adjustment device for heating and/or cooling the coolant in the irrigation line to adjust the temperature of the coolant in the irrigation line.

According to the ablation catheter disclosed by the invention, the ablation catheter can be freely switched into a radio frequency ablation mode or a pulse ablation mode, so that an operator can freely switch in the operation process, the ablation time can be greatly shortened, complications can be reduced, the ablation effect is improved, the temperature of cooling liquid in a perfusion pipeline can be adjusted to an appropriate temperature, the cooling liquid cooling effect can be ensured, and the damage of the cooling liquid to the area near a lesion part can be avoided.

In some examples of the invention, the ablation catheter further comprises: the medical liquid infusion line is at least partially arranged in the catheter body and is used for conveying medical liquid to a lesion part.

In some examples of the invention, the catheter body and/or the first electrode and/or the second electrode has a medical fluid outlet with which an outlet end of the medical fluid infusion line communicates.

In some examples of the invention, the catheter body comprises: the bending adjusting section is adjustable in bending degree, the first electrode is arranged at the free end of the bending adjusting section, and the second electrode is sleeved on the bending adjusting section.

In some examples of the invention, the second electrode is a plurality of second electrodes, and the plurality of second electrodes are sequentially spaced in a length direction of the turning section.

In some examples of the present invention, a distance between two adjacent second electrodes gradually decreases in a direction from the first electrode to the second electrode.

In some examples of the present invention, a width of one of the two adjacent second electrodes is L1, a width of the other of the two adjacent second electrodes is L3, and a separation distance between the two adjacent second electrodes is L2, which satisfies the following relation: 2R ═ c (L1+ L3)^d+ L2, where R is the desired optimal electric field radius, c is a coefficient value corresponding to the second electrode thickness, and d is a coefficient value corresponding to the second electrode diameter size.

In some examples of the invention, the spacing distance between any two adjacent second electrodes is 5mm to 10 mm.

In some examples of the invention, the catheter body further comprises: handle section, push rod and connecting piece, the connecting piece is located the pipe is originally internal, transfer the curved section to keep away from the tip of free end with the push rod is connected, the push rod with handle section is connected and relative handle section is movable, the connecting piece is connected transfer curved section with between the handle section, wherein, the push rod is relative in order to change during the handle section motion transfer curved section camber.

In some examples of the invention, the catheter body further comprises: the main body pipe section is connected between the bending adjusting section and the push rod, and the hardness of the main body pipe section is greater than that of the bending adjusting section.

In some examples of the invention, the ablation catheter further comprises: the driving device is arranged in the handle section and used for driving the push rod to move relative to the handle section so as to change the bending degree of the bending adjusting section.

In some examples of the invention, the first electrode is provided with a cooling fluid outlet, and one end of the irrigation line is in communication with the cooling fluid outlet.

In some examples of the invention, a coolant passage is provided in the first electrode to communicate the coolant outlet with the irrigation line.

In some examples of the invention, the ablation catheter further comprises: and the connecting device is respectively connected with the first electrode and the second electrode through a lead, and the lead is arranged in the catheter body.

In some examples of the invention, a thermocouple is connected between the connection device and the first electrode, the thermocouple being disposed within the catheter body, the thermocouple being configured to detect a temperature of the first electrode.

In some examples of the present invention, the first electrode is provided with a wire installation groove in which the wire is installed; the first electrode is further provided with a thermocouple installation groove, and the thermocouple installation groove is used for installing a thermocouple.

In some examples of the invention, the catheter body is provided with a first port and a second port, the first port being connected to the perfusion line, the second port being connected to the guide wire.

In some examples of the invention, the outer surface of the wire and/or the thermocouple is provided with a protective layer having insulation and a voltage resistance.

In some examples of the present invention, a sum of the number of the first electrodes and the number of the second electrodes is an even number.

In some examples of the invention, the temperature adjustment device comprises: the heat exchange pipeline is in contact heat exchange with the filling pipeline so as to heat and/or cool the cooling liquid in the filling pipeline.

In some examples of the invention, the heat exchange line is wound around an outer surface of the filling line.

In some examples of the invention, the temperature adjustment device further comprises: a heating member for heating the cooling liquid.

In some examples of the invention, the drive device comprises: the handle comprises a driving piece, a first driving part and a second driving part, wherein the first driving part is connected with the push rod, the second driving part is connected with the driving piece, and the driving piece drives the first driving part to drive the push rod to move relative to the handle section.

Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.

Drawings

The above and/or additional aspects and advantages of the present invention will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:

FIG. 1 is a schematic view of an ablation catheter according to an embodiment of the invention;

FIG. 2 is a schematic view of an ablation catheter, an energy switching device, a radio frequency ablation device and a pulse ablation device connection according to an embodiment of the invention;

FIG. 3 is a schematic assembly view of the pusher rod, handle segment and drive arrangement of an ablation catheter according to an embodiment of the invention;

FIG. 4 is a schematic view of a first electrode of an ablation catheter in accordance with an embodiment of the invention;

FIG. 5 is another schematic angular view of a first electrode of an ablation catheter in accordance with an embodiment of the invention;

fig. 6 is a schematic view of an ablation catheter ablating a lesion site in a radio frequency ablation mode in accordance with an embodiment of the present invention;

FIG. 7 is a schematic view of an ablation catheter ablating a lesion site in a pulse ablation mode according to an embodiment of the present invention;

fig. 8 is a graph of pulsed energy electric field versus electrode spacing for an ablation catheter in accordance with an embodiment of the present invention.

Reference numerals:

an ablation catheter 100;

a catheter body 10; a first electrode 11; a second electrode 12; a liquid medicine outlet 13; a bend-adjusting section 14; a handle section 15; a push rod 16; a connecting member 17; a main body tube section 18; a coolant outlet 19; a coolant passage 191; a wire mounting slot 192; a couple mounting groove 193; the mounting structure 194;

a filling line 20;

a temperature adjusting device 30; a heat exchange line 31; a first drive pump 32;

a medical liquid infusion line 40;

a drive device 50; a driving member 51; a first drive section 52; the second driving portion 53; a first tooth portion 54; a second tooth portion 55;

a connecting device 60; a wire 61; a thermocouple 62; an energy switching device 63; a connector 64;

a radiofrequency ablation device 200; a pulse ablation device 300; an extracorporeal auxiliary electrode 400; the lesion 500.

Detailed Description

Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the accompanying drawings are illustrative only for the purpose of explaining the present invention, and are not to be construed as limiting the present invention.

An ablation catheter 100 according to an embodiment of the invention is described below with reference to fig. 1-8, the ablation catheter 100 may be used in surgery, for example: ablation catheter 100 may be used in atrial fibrillation, and ablation catheter 100 is described herein for use in atrial fibrillation as an example. Atrial fibrillation is a common cardiac arrhythmia, and radiofrequency ablation is a common method currently used clinically to treat cardiac arrhythmias (e.g., atrial fibrillation), where ablation lesions must be sufficient to destroy the arrhythmic tissue or substantially interfere with or isolate abnormal electrical conduction in the myocardial tissue, but excessive ablation can affect surrounding healthy tissue as well as neural tissue. The radio frequency ablation point-by-point ablation operation has long time, high requirement on the catheter operation level of an operator, discomfort of a patient in the operation and easy pulmonary vein stenosis after the operation. Radiofrequency ablation can damage the cardiac endothelial surface, activate the extrinsic coagulation cascade, and lead to coke and thrombosis, which in turn can lead to systemic thromboembolism. Meanwhile, the application of rf energy to the target tissue affects non-target tissue, and the application of rf energy to atrial wall tissue may cause esophageal or nerve damage. In addition, radiofrequency ablation can also lead to scarring of the tissue, further leading to embolization problems. However, the radio frequency ablation has the advantages in atrial fibrillation surgery, the single-point ablation operation can enable energy to be concentrated on the head electrode to achieve a good ablation effect on the thick cardiac muscle tissue, and meanwhile, the single-point ablation mode is convenient for point-supplementing ablation on the position of the dew point during ablation.

Further, pulse ablation is also a method for treating atrial fibrillation, which is a high-voltage pulse electric field technology, and applies a short-time pulse high voltage to tissue cells to generate a local high-voltage electric field of hundreds of volts per centimeter, wherein the local high-voltage electric field is higher than a cell voltage penetration threshold, so that irreversible perforations are formed on cell membranes to destroy the cell membranes, so that biomolecular materials are exchanged across the cell membranes, and cell necrosis or apoptosis is caused. Since different tissue cells have different voltage penetration thresholds, the high voltage pulsed electric field technique can be selectively applied to myocardial cells (relatively low threshold) without affecting other non-target cellular tissues (e.g., nerves, esophagus, blood vessels, and blood). And the time for releasing energy when the pulse electric field is applied is very short, and the thermal effect cannot be generated, so that the problems of tissue damage, pulmonary vein stenosis and the like are avoided. Thus, pulse ablation is a non-thermogenic technique, the mechanism of injury is the creation of nano-scale micro-pores in certain cell membranes by high-frequency electrical pulses, and potential advantages of pulse ablation for atrial fibrillation ablation include: the tissue selectivity is realized, and the surrounding tissues can be protected from being damaged; the pulse electric field can be released quickly within a few seconds; ③ no coagulation necrosis, and the risk of Pulmonary Vein (PV) stenosis is reduced.

As shown in fig. 1-8, according to the ablation catheter 100 of the embodiment of the present invention, the ablation catheter 100 has a radio frequency ablation mode and a pulse ablation mode, that is, the ablation catheter 100 has two working modes of the radio frequency ablation mode and the pulse ablation mode. The ablation catheter 100 includes: a catheter body 10, a perfusion line 20 and a temperature regulating device 30. The catheter body 10 is provided with a first electrode 11 (head electrode) and a second electrode 12 (ring electrode), the first electrode 11 can be used as a radio frequency ablation electrode, the ablation catheter 100 can be switched between a radio frequency ablation mode and a pulse ablation mode by controlling the working states of the first electrode 11 and the second electrode 12, further, when the ablation catheter 100 is switched to the radio frequency ablation mode, the first electrode 11 can apply radio frequency energy to target tissue for thermal ablation, when the ablation catheter 100 is switched to the pulse ablation mode, the electrode pair formed by the first electrode 11 and the second electrode 12 can apply high-voltage pulse energy to the target tissue for pulse ablation, so that the pulse ablation function and the radio frequency ablation function can be integrated on one ablation catheter 100, an operator can freely switch the working mode of the ablation catheter 100 in an operation process, and esophageal or nerve injury easily caused by using radio frequency energy at a thinner part of myocardial tissue can be solved, The problem of imperviousness by pulse energy at a thick part of the myocardial tissue can be solved, and the problem of leak points with irregular shapes at the pulmonary vein opening can be solved, so that complications can be reduced, the ablation effect can be improved, and the ablation time can be greatly shortened.

Further, at least a part of the structure of the perfusion circuit 20 is disposed in the catheter body 10, it can also be understood that the whole structure of the perfusion circuit 20 is disposed in the catheter body 10, or a part of the structure of the perfusion circuit 20 is disposed in the catheter body 10, another part of the structure of the perfusion circuit 20 is disposed outside the catheter body 10, the perfusion circuit 20 is adapted to communicate with a perfusion pump, the perfusion circuit 20 is used for delivering a cooling liquid to the lesion 500, the cooling liquid may be physiological saline, when the ablation catheter 100 operates in the rf ablation mode, the perfusion circuit 20 delivers the physiological saline to the lesion 500, and the physiological saline is used for cooling during rf ablation, so that the rf ablation can be continuously performed. Thermostat 30 is used to heat and/or cool the coolant in fill line 20 to regulate the temperature of the coolant in fill line 20. Wherein, it melts the during operation under the mode to melt at the radio frequency to melt pipe 100, if normal saline's temperature is higher, normal saline's cooling effect is poor this moment, normal saline can not reach good cooling effect, if normal saline's temperature is lower, the coolant liquid causes damage (frostbite) to lesion part 500 (target tissue) near region easily, from this through temperature regulation apparatus 30 of this application, can adjust the temperature of cooling liquid to suitable temperature in irrigation pipe 20, when guaranteeing cooling liquid cooling effect, also can avoid the coolant liquid to cause the damage to lesion part 500 near region, can also guarantee that the radio frequency melts and can continuously go on.

Further, both the first electrode 11 and the second electrode 12 may be made of a platinum-iridium alloy, which has good energy conductivity, so that the ablation process is more efficient.

From this, through the ablation catheter 100 of this application, ablation catheter 100 can freely switch into radio frequency ablation mode or pulse ablation mode, can make the art person freely switch over at the operation in-process to can shorten the time of melting greatly, also can reduce the complication and promote the ablation effect, and, can adjust the temperature of cooling liquid to suitable temperature in the pipeline 20 that fills, can guarantee cooling liquid cooling effect, also can avoid the cooling liquid to cause the damage to the regional near pathological change position 500.

In some embodiments of the present invention, as shown in fig. 1, the ablation catheter 100 may further comprise: a medical liquid infusion line 40, at least a part of the medical liquid infusion line 40 is disposed in the catheter body 10, and the medical liquid infusion line 40 is used for delivering a medical liquid to a lesion 500 (target tissue). Wherein, current ablation catheter does not have the function of adding medicine to, in this application, through putting liquid medicine infusion line 40 on ablation catheter 100, can make ablation catheter 100 have the function of adding medicine to, can carry the liquid medicine to pathological change position 500 through ablation catheter 100 to can omit and use solitary device of adding medicine to add medicine to, and then can practice thrift medical resource. When the ablation catheter 100 is not used for the ablation operation, the ablation catheter 100 alone may be used for the administration of the drug.

In some embodiments of the present invention, as shown in fig. 1, the catheter body 10 and/or the first electrode 11 and/or the second electrode 12 has a medical fluid outlet 13, and preferably, the catheter body 10 is provided with the medical fluid outlet 13, and the outlet end of the medical fluid infusion line 40 communicates with the medical fluid outlet 13. Wherein, the liquid medicine infusion line 40 has an inlet end, the inlet end of the liquid medicine infusion line 40 is used for communicating with a medicine storage device for storing liquid medicine, after the liquid medicine in the medicine storage device flows into the liquid medicine infusion line 40 through the inlet end of the liquid medicine infusion line 40, the liquid medicine in the liquid medicine infusion line 40 flows to a target tissue from the liquid medicine outlet 13, and the medicine administration is completed.

In some embodiments of the present invention, as shown in fig. 1, the catheter body 10 may comprise: the bending degree of the bending adjusting section 14 is adjustable, that is, the bending degree of the bending adjusting section 14 is adjustable, further, after the bending adjusting section 14 is bent, the bending adjusting section 14 can be restored to an original shape, the bending adjusting section 14 is provided with an electrode, the first electrode 11 is arranged at the free end of the bending adjusting section 14, and the second electrode 12 is sleeved on the bending adjusting section 14. Wherein, the free end of the bending section 14 is the left end in fig. 1, the second electrode 12 is sleeved on the outer surface of the bending section 14, and the first electrode 11 and the second electrode 12 can be accurately delivered to the lesion part 500 by adjusting the bending degree of the bending section 14.

In some embodiments of the present invention, as shown in fig. 1, the second electrode 12 may be provided in a plurality, and the plurality of second electrodes 12 are sequentially spaced apart in a length direction of the bending section 14. The length direction of the bending section 14 is the left-right direction in fig. 1, further, the number of the second electrodes 12 may be three, the three second electrodes 12 are sequentially arranged at intervals, the number of the first electrodes 11 may be one, in the pulse ablation mode, the first electrode 11 and any one second electrode 12 of the plurality of second electrodes 12 form a positive-negative electrode pair, or any two second electrodes 12 of the plurality of second electrodes 12 form an electrode pair, each electrode pair can independently generate a pulse electric field to act on a target tissue (for example, cardiac muscle cells), and when the ablation catheter 100 ablates, a single-pair or multiple-pair electrode ablation can be selected according to an operation requirement, so that the ablation time can be further shortened, and the operation efficiency can be improved.

In some embodiments of the present invention, as shown in fig. 1, the spacing distance between two adjacent second electrodes 12 gradually decreases from the first electrode 11 to the second electrode 12, such that the spacing distance between the plurality of second electrodes 12 is suitable, and when the ablation catheter 100 is in the pulse ablation mode, the ablation catheter 100 can have sufficient electric field ablation strength, and the electrode pair formed by the first electrode 11 and the second electrode 12 can also have sufficient electric field ablation strength.

In some embodiments of the present invention, as shown in fig. 1 and 8, each of the second electrodes 12 is circular, a width of one second electrode 12 of two adjacent second electrodes 12 is L1, a width of the other second electrode 12 is L3, and a separation distance between two adjacent second electrodes 12 is L2, which satisfies the following relation: 2R ═ c (L1+ L3)^d+ L2, where R is the desired optimal electric field radius, c is the coefficient value corresponding to the thickness of the second electrode 12, d is the coefficient value corresponding to the diameter of the second electrode 12, where the ablation catheter 100 is in the pulse ablation mode, assuming the voltage is constant, the ablation effect of the ablation catheter 100 is positively correlated to the electric field range R, further, R may be set to 7mm, the thickness of the second electrode 12 may be set to 0.5mm, c may be 0.35, the diameter of the second electrode 12 may be 7F, d may be 2, and L1 may be set to 2.24mm, which can ensure that the ablation catheter 100 has better electric field ablation strength and range.

In some embodiments of the present invention, the spacing distance between any two adjacent second electrodes 12 may be set to 5mm-10mm, and further, the spacing distance between two adjacent second electrodes 12 may be set to 7mm, which further enables the second electrodes 12 to accommodate both rf ablation and pulse ablation.

In some embodiments of the present invention, as shown in fig. 1 and 3, the catheter body 10 may further comprise: the handle section 15, the push rod 16 and the connecting piece 17, the connecting piece 17 is arranged in the catheter body 10, the connecting piece 17 can be a pull wire, the pull wire can be made of nickel-titanium alloy wires or high-elasticity stainless steel wires, the pull wire can be restored to a straight state after bending is required to be met, the end part of the bending adjusting section 14 far away from the free end is connected with the push rod 16, namely, in the left-right direction in fig. 1, the right end of the bend adjusting section 14 is connected with a push rod 16, the push rod 16 is connected with the handle section 15 and is movable relative to the handle section 15, and further, the left-right direction push rod 16 in fig. 1 is slidable with respect to the handle section 15, the connecting member 17 is connected between the turning section 14 and the handle section 15, when the push rod 16 moves relative to the handle segment 15, the bending degree of the bending adjusting segment 14 is changed, so that the bending degree of the bending adjusting segment 14 is adjusted, and the first electrode 11 and the second electrode 12 are accurately delivered to the lesion part 500.

In some embodiments of the present invention, as shown in fig. 1, the catheter body 10 may further comprise: a body tube section 18, the body tube section 18 being connected between the bend adjustment section 14 and the push rod 16. Further, the bend adjusting section 14 and the main body section 18 may be made of high polymer materials such as polyether block polyamide, polyurethane thermoplastic elastomer, etc., the hardness of the main body section 18 is greater than that of the bend adjusting section 14, metal woven wires may be added inside the main body section 18, the bend adjusting section 14 and the main body section 18 may be connected together by gluing, hot melting, laser welding, etc., and the main body section 18 may play a supporting role when the bend of the bend adjusting section 14 is adjusted.

In some embodiments of the present invention, as shown in fig. 3, the ablation catheter 100 may further comprise: the driving device 50, the driving device 50 is disposed in the handle section 15, and the driving device 50 is used for driving the push rod 16 to move relative to the handle section 15 so as to change the bending degree of the bending section 14. The driving device 50 is used for driving the push rod 16 to move relative to the handle section 15 in the length direction of the ablation catheter 100, as shown in fig. 3, the length direction of the ablation catheter 100 is the left-right direction in fig. 3, the push rod 16 is driven by the driving device 50 to move relative to the handle section 15 in the left-right direction of the ablation catheter 100, the bending degree of the bending adjusting section 14 can be adjusted, the bending adjusting section 14 can be adjusted to different bending degrees by different moving distances of the push rod 16 relative to the handle section 15, the bending degree of the bending adjusting section 14 can be adjusted automatically, an operator does not need to manually control the push rod 16 to adjust the bending degree of the bending adjusting section 14, and the physical strength of the operator is saved.

In some embodiments of the present invention, as shown in fig. 3, a mounting structure 194 may be disposed in the handle segment 15, the mounting structure 194 may be configured as a mounting post, one end of the connecting member 17 is fixedly connected to the mounting structure 194, the other end of the connecting member 17 is fixedly connected to the bending adjustment segment 14, and when the driving device 50 drives the push rod 16 to move relative to the handle segment 15, for example: when the driving device 50 drives the push rod 16 to move leftwards as shown in fig. 3, the bending degree of the bending adjusting section 14 can be adjusted under the combined action of the connecting piece 17 and the push rod 16.

In some embodiments of the present invention, as shown in fig. 1, the connecting member 17 passes through the push rod 16 so that the connecting member 17 is connected to both the bending adjusting section 14 and the handle section 15, wherein after the connecting member 17 passes through the push rod 16, one end of the connecting member 17 is connected to the bending adjusting section 14, and the other end of the connecting member 17 is connected to the mounting structure 194 of the handle section 15, so that the connecting member 17 is connected to the bending adjusting section 14 and the handle section 15, and the connecting member 17 can be disposed in the catheter body 10.

In some embodiments of the present invention, the ablation catheter 100 may further comprise: and a locking device for locking or unlocking the push rod 16 and the handle segment 15. After the bending degree of the bending adjusting section 14 is adjusted, the locking device locks the push rod 16 and the handle section 15, so that the relative positions of the push rod 16 and the handle section 15 are fixed, at the moment, the push rod 16 cannot move relative to the handle section 15, when the bending degree of the bending adjusting section 14 needs to be adjusted, the locking device unlocks the push rod 16 and the handle section 15, at the moment, the push rod 16 can move relative to the handle section 15, and the purpose of adjusting the bending degree of the bending adjusting section 14 is achieved.

Further, the locking device may include a locking pin, the push rod 16 may be provided with a first locking hole, the handle section 15 may be provided with a second locking hole matched with the first locking hole, the first locking hole may be provided with one, the second locking hole may be provided with a plurality of holes, or the second locking hole may be provided with one, the first locking hole may be provided with a plurality of holes, or the second locking hole and the first locking hole may be provided with a plurality of holes, after the bending degree of the bending adjusting section 14 is adjusted, the first locking hole and the second locking hole are simultaneously inserted through the locking pin, the relative positions of the push rod 16 and the handle section 15 may be fixed, when the bending degree of the bending adjusting section 14 needs to be adjusted, the locking pin is extracted, at this time, the push rod 16 can move relative to the section 15, and the purpose of adjusting the bending degree of the bending adjusting section 14 is achieved. It should be noted that the specific structure of the locking device is not limited, and it is sufficient that the locking device can lock or unlock the push rod 16 and the handle segment 15.

In some embodiments of the present invention, the handle section 15 is provided with a first guide portion, and the push rod 16 is provided with a second guide portion, and the push rod 16 can move relative to the handle section 15 in the length direction of the ablation catheter 100 through the guide cooperation of the first guide portion and the second guide portion. Further, the first guide portion can be set as one of a sliding block and a sliding groove, the second guide portion can be set as the other of the sliding block and the sliding groove, the extending direction of the sliding groove is the same as the length direction of the ablation catheter 100, the sliding block and the sliding groove are in guiding fit, the moving direction of the push rod 16 can be limited, the push rod 16 can move in a fixed direction relative to the handle section 15, and therefore the bending degree of the bending adjusting section 14 can be better adjusted.

In some embodiments of the present invention, as shown in fig. 3, the driving device 50 may include: the handle comprises a driving piece 51, a first driving part 52 and a second driving part 53, wherein the first driving part 52 is connected with the push rod 16, the second driving part 53 is connected with the driving piece 51, and the driving piece 51 drives the first driving part 52 to drive the push rod 16 to move relative to the handle section 15 by driving the second driving part 53. The first driving portion 52 and the second driving portion 53 are connected in a matching manner, and when the driving member 51 works, the driving member 51 can drive the second driving portion 53 to drive the first driving portion 52 to drive the push rod 16 to move relative to the handle section 15 in the length direction of the ablation catheter 100, so that the bending degree of the bending section 14 can be automatically adjusted.

Further, the driving member 51 drives the second driving portion 53 to rotate, so that the second driving portion 53 drives the first driving portion 52 to drive the push rod 16 to move relative to the handle segment 15. The driving member 51 may be a driving motor, an output shaft of the driving motor is fixedly connected to the second driving portion 53, when the driving motor works, the driving motor drives the second driving portion 53 to rotate, and when the second driving portion 53 rotates, the driving motor drives the first driving portion 52 to drive the push rod 16 to move relative to the handle segment 15.

Further, as shown in fig. 3, the first drive portion 52 has a first tooth portion 54, and the second drive portion 53 has a second tooth portion 55 on an outer surface thereof to be engaged with the first tooth portion 54. The first driving portion 52 may be configured as a rack, the second driving portion 53 may be configured as a worm, the outer surface of the worm is provided with a second tooth portion 55, when the driving motor works, the worm is driven to rotate, and when the worm rotates, the first driving portion 52 is driven to drive the push rod 16 to move relative to the handle section 15, so that the automatic adjustment of the bending degree of the bending section 14 can be realized.

In some embodiments of the present invention, the ablation catheter 100 may further comprise: and a controller, the controller is connected with the driving device 50, and further, the controller is connected with the driving device 50 in a communication way and is used for controlling the distance for which the driving device 50 drives the push rod 16 to move relative to the handle section 15. Wherein, whether the controller can control driving motor and work, through controller control driving motor's operating time, can accurate control push rod 16 distance relative handle section 15 motion, can accurate regulation transfer 14 bendings of curved section.

Further, handle section 15 can be provided with adjustment button, and adjustment button and controller communication are connected, and the art person can be through whether the work of adjustment button control controller control driving motor. For example: when the operator presses the adjusting button, the controller controls the driving motor to work and adjust the bending degree of the bending adjusting section 14, and when the operator does not press the adjusting button, the controller does not control the driving motor to work.

In some embodiments of the present invention, a driving member 51 mounting portion may be disposed in the handle segment 15, the driving member 51 is mounted on the driving member 51 mounting portion, and a buffer pad is disposed between the driving member 51 and the handle segment 15. The power cord of the driving member 51 can be connected to the connector 64 to supply power to the driving member 51, the driving member 51 is fixed in the handle segment 15 through the mounting portion of the driving member 51, and the driving member 51 can be mounted at the mounting portion of the driving member 51 through a bolt, so that the driving member 51 can be stably mounted in the handle segment 15. Moreover, by arranging the buffer pad, when the driving element 51 works, the buffer pad can absorb the vibration generated by the driving element 51, so that the vibration of the ablation catheter 100 can be reduced, and an operator can accurately move the ablation catheter 100 to the lesion part 500.

In some embodiments of the present invention, as shown in fig. 4 and 6, the first electrode 11 may be provided with a cooling liquid outlet 19, and one end (outlet end) of the irrigation line 20 communicates with the cooling liquid outlet 19. Wherein the first electrode 11The shape of the first electrode 11 can be cylindrical, circular ring or spherical, etc., the length of the first electrode 11 is not less than 3mm, the diameter of the first electrode 11 is not less than 7F, and the surface area of the first electrode 11 is 30mm²-40mm²So as to ensure that the ablation catheter 100 can achieve good ablation effect in the radio frequency ablation mode. Further, when the ablation catheter 100 is in the radiofrequency ablation mode, only the first electrode 11 performs radiofrequency ablation, and meanwhile, the cooling liquid outlet 19 meets the requirement that cold saline can flow out at a rate of 50ml/mim-100ml/mim, so that the cooling requirement in the radiofrequency ablation mode is met, and the radiofrequency ablation can be continuously performed.

Further, a cooling liquid channel 191 for communicating the cooling liquid outlet 19 and the filling line 20 may be disposed in the first electrode 11, that is, the cooling liquid channel 191 communicates the cooling liquid outlet 19 and the filling line 20, and the cooling liquid in the filling line 20 may flow to the cooling liquid outlet 19 through the cooling liquid channel 191, so as to perform a cooling liquid filling function.

In some embodiments of the present invention, as shown in fig. 1, the ablation catheter 100 may further comprise: the connecting device 60, the connecting device 60 can be respectively connected with the first electrode 11 and the second electrode 12 through a conducting wire 61, the conducting wire 61 is arranged in the catheter body 10, the first electrode 11 and the connecting device 60 are connected through a separate conducting wire 61, and the second electrode 12 and the connecting device 60 are connected through a separate conducting wire 61. Further, the lead 61 can transmit two kinds of energy, i.e. radio frequency energy and pulse energy, the connecting device 60 can be disposed at the right end of the handle section 15, as an embodiment of the present invention, the connecting device 60 can be configured as a connector 64, the connector 64 has high voltage resistance and insulating property, the connector 64 meets the requirement of interfacing with the radio frequency ablation device 200 and the pulse ablation device 300, the connector 64 has multiple plugging and unplugging properties, the connector 64 can be connected with an external ablation device to transmit radio frequency or pulse signals, in the rf ablation mode, the connector 64 may transmit rf signals to the first electrode 11, in the pulse ablation mode, the connector 64 may transmit a radio frequency signal to the first electrode 11 and the second electrode 12, the first electrode 11 and the second electrode 12 forming a positive and negative electrode pair, and the first electrode 11 and the second electrode 12 forming a pulsed electric field therebetween, causing irreversible perforation of the myocardial lesion cells.

As another embodiment of the present invention, the connection device 60 can be configured as an energy switching device 63 (energy converter), the energy switching device 63 can be installed in the handle section 15 of the catheter body 10, and the radiofrequency ablation device 200 and the pulse ablation device 300 are simultaneously connected to the energy switching device 63, so that the two energies can be directly switched on the energy converter, and the ablation procedure can be continuously performed. It is noted that it is within the scope of the present application to integrate the rf ablation device 200, the pulse ablation device 300, and the energy converter into a single system.

Further, the connection of ablation catheter 100 to rf ablation device 200 and pulse ablation device 300 may reduce the energy switching device 63 by directly connecting either rf ablation device 200 or pulse ablation device 300 to connector 64, where ablation catheter 100 requires two cables, where connector 64 is connected to the cable on rf ablation device 200 when rf ablation is required and where connector 64 is connected to the cable on pulse ablation device 300 when pulse ablation is required, in a manner that is directly abbreviated but has an effect on the continuity of the procedure.

In some embodiments of the present invention, as shown in fig. 1, a thermocouple 62 is connected between the connection device 60 and the first electrode 11, the thermocouple 62 is disposed in the catheter body 10, and the thermocouple 62 is used for detecting the temperature of the first electrode 11. Wherein, one end of the thermocouple 62 is connected with the first electrode 11, the other end of the thermocouple 62 is connected with the connecting device 60 (connector 64), and the thermocouple 62 can transmit the detected temperature signal of the first electrode 11 to the detecting device through the connecting device 60, so that the temperature of the first electrode 11 can be monitored in real time.

In some embodiments of the present invention, as shown in fig. 5, the first electrode 11 is provided with a wire installation groove 192, and one end of the wire 61 is installed in the wire installation groove 192, wherein one end of the wire 61 connected to the first electrode 11 is installed in the wire installation groove 192, so that the wire 61 is connected to the first electrode 11. Further, as shown in fig. 5, the first electrode 11 is further provided with a thermocouple installation groove 193, and the thermocouple installation groove 193 is used for installing the thermocouple 62. Wherein, one end of the thermocouple 62 is installed in the thermocouple installation groove 193, which is convenient for the thermocouple 62 to be connected with the first electrode 11.

In some embodiments of the present invention, the catheter body 10 may be provided with a first interface and a second interface, the first interface is connected to the filling line 20, the filling line 20 is integrally disposed in the catheter body 10, one end of the filling line 20 is communicated with the cooling liquid outlet 19, the other end of the filling line 20 is communicated with the first interface, the first interface is used for being connected to an external filling pump, the filling pump pumps the cooling liquid into the filling line 20 when the filling pump is operated, and the cooling liquid in the filling line 20 flows to the cooling liquid outlet 19 along the filling line 20.

In some embodiments of the present invention, a second interface is connected to the lead 61, wherein the second interface can interface with the rf ablation device 200 and the impulse ablation device 300, and the second interface can be connected to an external ablation device to transmit rf or impulse signals, and in the rf ablation mode, the second interface can transmit rf signals to the first electrode 11, and in the impulse ablation mode, the second interface can transmit rf signals to the first electrode 11 and the second electrode 12.

In some embodiments of the present invention, the outer surface of the wire 61 and/or the thermocouple 62 is provided with a protective layer having insulation and voltage resistance. Further, protective layers are arranged on the outer surfaces of the lead 61 and the thermocouple 62, the lead 61 and the thermocouple 62 are wrapped by the protective layers, the protective layers can meet the insulation requirements during radio frequency energy transmission and the high-voltage resistance requirements during pulse energy transmission, and the lead 61 and the thermocouple 62 can be protected by the protective layers. Furthermore, the protective layer can be made of polyimide resin, polyether ether ketone resin and base liquid, the protective layer has good insulating performance, the protective layer is not easy to fall off after being coated on the outer surfaces of the lead 61 and the thermocouple 62, and the high-voltage resistant grade of the protective layer can reach more than 2000V.

Furthermore, because the stay wire is made of metal materials, the protective layer is coated on the outer surface of the stay wire, and the stay wire can achieve an insulating effect.

In some embodiments of the present invention, an insulating sleeve may be sleeved outside the thermocouple 62, and the insulating sleeve may protect the thermocouple 62 and prevent the thermocouple 62 from being punctured by an instantaneous high voltage during the pulse ablation.

In some embodiments of the present invention, the sum of the number of the first electrodes 11 and the number of the second electrodes 12 is an even number, for example: the first electrode 11 is provided as one, the second electrodes 12 are provided as three, the first electrode 11 and the second electrode 12 can be randomly formed into an electrode pair, any two second electrodes 12 in the plurality of second electrodes 12 can be randomly formed into an electrode pair, and each electrode pair can independently generate a pulse to act on the myocardial cells.

In some embodiments of the present invention, the turning section 14 may be provided with a first pipe, a second pipe, a third pipe and a fourth channel, the first pipe, the second pipe, the third pipe and the fourth channel are independent from each other, the first pipe is used for a lead 61 for transmitting radio frequency and pulse energy to pass through, the second pipe is used for a pull wire for adjusting the bending shape of the turning section 14 to pass through, the third pipe is used for a perfusion pipeline 20 to pass through, and the fourth pipe is used for a thermocouple 62 to pass through, so that the arrangement can facilitate the connection of the lead 61 and the first electrode 11, the connection of the lead 61 and the second electrode 12, the connection of the pull wire and the turning section 14, the communication of the perfusion pipeline 20 and the cooling liquid outlet 19, and the assembly of the thermocouple 62 and the first electrode 11.

In some embodiments of the present invention, as shown in fig. 1, the temperature adjustment device 30 may include: a heat exchange line 31, wherein the heat exchange line 31 exchanges heat with the filling line 20 to heat and/or cool the cooling liquid in the filling line 20. Wherein, heat transfer pipeline 31 and filling line 20 after the contact, the heat can be in the heat transfer pipeline 31 with fill the pipeline 20 between the transmission, can reach the effect of control coolant temperature with the temperature regulation of coolant liquid to suitable temperature.

Further, as shown in fig. 1, heat exchange line 31 is around establishing at filling line 20 surface, so set up and to increase heat exchange line 31 and filling line 20 area of contact, in the unit interval, can promote heat exchange line 31 and filling line 20's heat exchange efficiency to can be more quick with coolant temperature regulation to suitable temperature range in.

In some embodiments of the present invention, the heat exchange pipeline 31 extends in the length direction of the filling pipeline 20, and the length direction of the filling pipeline 20 refers to the left-right direction in fig. 1, so that the contact area between the heat exchange pipeline 31 and the filling pipeline 20 can be further increased, and the heat exchange efficiency between the heat exchange pipeline 31 and the filling pipeline 20 can be further improved in unit time, so as to adjust the temperature of the coolant to a suitable temperature range more quickly.

In some embodiments of the present invention, the heat exchanging pipeline 31 and the filling pipeline 20 are bonded and connected by a heat conducting glue, so that the heat exchanging pipeline 31 and the filling pipeline 20 can be stably assembled together, the relative position between the heat exchanging pipeline 31 and the filling pipeline 20 can be prevented from being changed, and the heat exchanging efficiency between the heat exchanging pipeline 31 and the filling pipeline 20 can be further improved.

In some embodiments of the present invention, the heat exchange pipeline 31 has a heat exchange medium therein, and the heat exchange medium exchanges heat with the cooling liquid through the heat exchange pipeline 31 and the filling pipeline 20, in this embodiment, the heat exchange medium may be liquid water, and can exchange heat with the cooling liquid through the liquid water flowing in the heat exchange pipeline 31, when the temperature of the cooling liquid is higher than the temperature of the liquid water, the heat of the cooling liquid is transferred to the liquid water, so as to achieve an effect of cooling the cooling liquid, and when the temperature of the cooling liquid is lower than the temperature of the liquid water, the heat of the liquid water is transferred to the cooling liquid, so as to achieve an effect of heating the cooling liquid.

Further, the temperature adjustment device 30 may further include: a first driving pump 32, the first driving pump 32 being in communication with the heat exchange line 31, the first driving pump 32 being adapted to pump a heat exchange medium into the heat exchange line 31 and to drive the heat exchange medium to flow in the heat exchange line 31. Wherein, the outside of the ablation catheter 100 can be provided with a liquid water storage container for storing liquid water, the first driving pump 32 is connected between the heat exchange pipeline 31 and the liquid water storage container, and the first driving pump 32 can drive the liquid water to circularly flow between the heat exchange pipeline 31 and the liquid water storage container, so that the heat exchange efficiency between the liquid water and the cooling liquid can be ensured.

In some embodiments of the present invention, the heat exchange line 31 has a phase change medium therein, through which the phase change heat absorption cools the cooling fluid. The phase change medium can be set to be liquid nitrogen, and the liquid nitrogen vaporization heat absorption principle can be utilized to cool the cooling liquid.

Further, the temperature adjustment device 30 may further include: and the second driving pump is communicated with the heat exchange pipeline 31 and is suitable for pumping the phase change medium into the heat exchange pipeline 31 and driving the phase change medium to flow in the heat exchange pipeline 31. The phase change medium storage container for storing the phase change medium can be arranged outside the ablation catheter 100, the second driving pump is connected between the heat exchange pipeline 31 and the phase change medium storage container, and the second driving pump can drive the phase change medium to circularly flow between the heat exchange pipeline 31 and the phase change medium storage container, so that the cooling effect of the cooling liquid can be ensured. Further, the flow of the liquid nitrogen can be adjusted through the second driving pump, so that the effect of controlling the temperature is achieved.

It should be noted that, when the coolant needs to be heated, the heat exchange medium may be pumped into the heat exchange pipeline 31 by the first driving pump 32, and when the coolant needs to be cooled, the heat exchange medium may be pumped into the heat exchange pipeline 31 by the first driving pump 32, or the phase change medium may be pumped into the heat exchange pipeline 31 by the second driving pump.

In some embodiments of the present invention, the temperature adjustment device 30 may further include: the heating member, the heating member is used for heating the coolant liquid, and wherein, the heating member can set up to the heating pipe, and the heating pipe can set up at filling line 20 surface, and the heating member can direct heating filling line 20 to can make the coolant liquid rapid heating up, and then can be more quick with coolant liquid temperature regulation to suitable temperature within range. The present invention is not limited thereto and the heating member may be provided inside the priming line 20.

In some embodiments of the present invention, the filling line 20 may be provided with a limiting structure for limiting the heat exchange line 31 to position the relative position between the filling line 20 and the heat exchange line 31. Wherein, limit structure can set up to spacing arch, and spacing arch can set up the surface at filling line 20, and spacing arch can be provided with a plurality ofly, and a plurality of spacing archs are spaced apart in proper order at filling line 20 length direction, is formed with the spacing groove between two adjacent spacing archs, and heat exchange line 31 installs between two adjacent spacing archs, and it is spacing to heat exchange line 31 through two adjacent spacing archs, can fix a position the relative position between filling line 20 and heat exchange line 31.

In some embodiments of the present invention, as shown in fig. 6, in the rf ablation mode, the ablation catheter 100 is used for unipolar ablation of the first electrode 11, and an external auxiliary electrode 400 is used to form a complete ablation loop, and during the rf ablation mode, the top (i.e. the left end in fig. 1) of the first electrode 11 is kept against the myocardial tissue (lesion 500) to achieve better ablation effect. Further, a pressure sensor or a magnetic positioning sensor may be provided within the catheter body 10, for example: be provided with pressure sensor in the pipe body 10, pressure sensor is connected with first electrode 11, and ablation pipe 100 is when the mode work of radiofrequency ablation, and pressure sensor can detect out the pressure that first electrode 11 receives, and when pressure sensor detected out that pressure that first electrode 11 receives reaches the preset threshold value, prove that the top of first electrode 11 pastes and leans on the cardiac muscle tissue, if pressure sensor detects out that pressure that first electrode 11 receives does not reach the preset threshold value, prove that the top of first electrode 11 does not paste and lean on the cardiac muscle tissue. Further, the pressure sensor may be connected to an external detection device, and the pressure sensor may transmit a detected pressure signal to the external detection device, so that the operator can accurately know whether the top of the first electrode 11 is attached to the myocardial tissue.

It should be noted that, when the pulse voltage is 400v/cm and the width of the second electrode 12 is fixed, the distance between two adjacent second electrodes 12 and the lesion depth are simulated, and when the electrode distance is about 7mm, the lesion depth reaches the maximum, and the lesion depth decreases when the electrode distance is too large or too small, so that when designing the ablation catheter 100, the distance between two adjacent second electrodes 12 is set to be 6mm to 8mm, preferably, the distance between two adjacent second electrodes 12 is set to be 7 mm.

According to the ablation catheter 100 provided by the embodiment of the invention, the bending section 14 is provided with the head electrode (the first electrode 11) and the ring electrode (the second electrode 12), so that effective radiofrequency ablation energy and an annular pulse electric field can be generated, a good transmural ablation effect can be achieved on a cardiac tissue with a thick wall thickness in a radiofrequency ablation mode, and a target tissue can be selectively ablated to reduce damage to cells in the pulse electric field ablation mode. When the ablation catheter 100 is used for treating irregular pulmonary vein orifices with different shapes, the operation effectiveness is higher by adopting a point-by-point ablation mode, the ablation catheter 100 well solves the problems that the pure radio frequency ablation catheter 100 is easy to cause esophagus or nerve injury at a thinner part of a myocardial tissue and the pure pulse ablation catheter 100 is impermeable at a thicker part of the myocardial tissue, and simultaneously solves the problem that points are easy to leak during ablation of the irregular pulmonary vein orifices while greatly shortening the operation time.

In the description herein, references to the description of the term "one embodiment," "some embodiments," "an illustrative embodiment," "an example," "a specific example," or "some examples" or the like mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

While embodiments of the invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.

Claims

1. An ablation catheter having a radio frequency ablation mode and a pulse ablation mode, comprising:

the catheter body is provided with a first electrode and a second electrode, and the ablation catheter is switched between the radio frequency ablation mode and the pulse ablation mode by controlling the working states of the first electrode and the second electrode;

the perfusion pipeline is at least partially arranged in the catheter body and used for conveying cooling liquid to a lesion part;

a temperature adjustment device for heating and/or cooling the coolant in the irrigation line to adjust the temperature of the coolant in the irrigation line.

2. The ablation catheter of claim 1, further comprising: the medical liquid infusion line is at least partially arranged in the catheter body and is used for conveying medical liquid to a lesion part.

3. The ablation catheter of claim 2, wherein said catheter body and/or said first electrode and/or said second electrode has a medical fluid outlet with which an outlet end of said medical fluid infusion line communicates.

4. The ablation catheter of claim 1, wherein the catheter body comprises: the bending adjusting section is adjustable in bending degree, the first electrode is arranged at the free end of the bending adjusting section, and the second electrode is sleeved on the bending adjusting section.

5. The ablation catheter of claim 4, wherein the second electrode is a plurality of second electrodes, the plurality of second electrodes being sequentially spaced apart along a length of the bend section.

6. The ablation catheter of claim 5, wherein a spacing distance between two adjacent second electrodes gradually decreases in a direction from the first electrode to the second electrode.

7. The ablation catheter of claim 5, wherein one of said second electrodes has a width of L1, the other of said second electrodes has a width of L3, and the adjacent second electrodes are spaced apart by a distance of L3Is L2, satisfies the relation: 2R ═ c (L1+ L3)^d+ L2, where R is the desired optimal electric field radius, c is a coefficient value corresponding to the second electrode thickness, and d is a coefficient value corresponding to the second electrode diameter size.

8. The ablation catheter of claim 5, wherein the spacing distance between any two adjacent second electrodes is 5mm to 10 mm.

9. The ablation catheter of claim 4, wherein the catheter body further comprises: handle section, push rod and connecting piece, the connecting piece is located the pipe is originally internal, transfer the curved section to keep away from the tip of free end with the push rod is connected, the push rod with handle section is connected and relative handle section is movable, the connecting piece is connected transfer curved section with between the handle section, wherein, the push rod is relative in order to change during the handle section motion transfer curved section camber.

10. The ablation catheter of claim 9, wherein the catheter body further comprises: the main body pipe section is connected between the bending adjusting section and the push rod, and the hardness of the main body pipe section is greater than that of the bending adjusting section.

11. The ablation catheter of claim 9, further comprising: the driving device is arranged in the handle section and used for driving the push rod to move relative to the handle section so as to change the bending degree of the bending adjusting section.

12. The ablation catheter of claim 1, wherein the first electrode is provided with a coolant outlet, one end of the irrigation line being in communication with the coolant outlet.

13. The ablation catheter of claim 12, wherein a coolant passage is provided in the first electrode communicating the coolant outlet and the irrigation line.

14. The ablation catheter of claim 1, further comprising: and the connecting device is respectively connected with the first electrode and the second electrode through a lead, and the lead is arranged in the catheter body.

15. The ablation catheter of claim 14, wherein a thermocouple is coupled between said coupling device and said first electrode, said thermocouple being disposed within said catheter body, said thermocouple being configured to sense a temperature of said first electrode.

16. The ablation catheter of claim 15, wherein the first electrode is provided with a wire mounting slot, the wire being mounted within the wire mounting slot;

the first electrode is further provided with a thermocouple installation groove, and the thermocouple installation groove is used for installing a thermocouple.

17. The ablation catheter of claim 14, wherein the catheter body is provided with a first port and a second port, the first port being connected to the irrigation line and the second port being connected to the guidewire.

18. The ablation catheter of claim 15, wherein an outer surface of said wire and/or said thermocouple is provided with a protective layer having insulation and voltage resistance.

19. The ablation catheter of claim 5, wherein a sum of the number of the first electrodes and the number of the second electrodes is an even number.

20. The ablation catheter of claim 1, wherein the temperature regulating device comprises: the heat exchange pipeline is in contact heat exchange with the filling pipeline so as to heat and/or cool the cooling liquid in the filling pipeline.

21. The ablation catheter of claim 20, wherein the heat exchange line is disposed around an outer surface of the irrigation line.

22. The ablation catheter of claim 20, wherein the temperature regulating device further comprises: a heating member for heating the cooling liquid.

23. The ablation catheter of claim 11, wherein the drive device comprises: the handle comprises a driving piece, a first driving part and a second driving part, wherein the first driving part is connected with the push rod, the second driving part is connected with the driving piece, and the driving piece drives the first driving part to drive the push rod to move relative to the handle section.